Mad Cow Disease----- Mad Cow Disease----- -- The Past History of Mad Cow Disease -- The Past History of Mad Cow Disease -- All about Mechanisms -- All about Mechanisms -- Other analogous diseases -- Other analogous diseases -- Great impact Mad Cow Disease Had Cause -- Great impact Mad Cow Disease Had Cause d d B9202066 B9202066 湛湛湛 湛湛湛 B9202097 B9202097 湛湛湛 湛湛湛 B9202099 B9202099 湛湛湛 湛湛湛 B9202101 B9202101 湛湛湛 湛湛湛
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Mad Cow Disease----- -- The Past History of Mad Cow Disease -- All about Mechanisms -- Other analogous diseases -- Great impact Mad Cow Disease Had Caused.
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Mad Cow Disease-----Mad Cow Disease-----
-- The Past History of Mad Cow Disease-- The Past History of Mad Cow Disease
-- All about Mechanisms-- All about Mechanisms
-- Other analogous diseases-- Other analogous diseases
-- Great impact Mad Cow Disease Had Caused-- Great impact Mad Cow Disease Had Caused
1957 Carleton Gajdusek in Ne1957 Carleton Gajdusek in New Guineaw Guinea
About “Kuru” ………….About “Kuru” ………….
1982 Stanley B. Prusiner’s expe1982 Stanley B. Prusiner’s experimentriment
……About “Prion”……About “Prion”
What Causes Mad Cow DiseaseWhat Causes Mad Cow Disease
In 1982,In 1982, Stanley B. Prusiner purified the Stanley B. Prusiner purified the pathogen of mad cow disease in his labpathogen of mad cow disease in his laboratory.oratory.
He found that the pathogen was compoHe found that the pathogen was composed of a kind of protein and named it sed of a kind of protein and named it prproteinaceous infectious particle.oteinaceous infectious particle.
Actually, there are two kinds of prion, Actually, there are two kinds of prion, PrPc PrPc and and PrPscPrPsc
PrPc can be found in the brain of PrPc can be found in the brain of normal, health animals and does not normal, health animals and does not cause diseases.cause diseases.
PrPsc is the prion that causes PrPsc is the prion that causes diseases. diseases.
The polypeptides that form PrPc and PrThe polypeptides that form PrPc and PrPsc are the same, but PrPsc is misfoldePsc are the same, but PrPsc is misfolded. The main secondary structure of PrPd. The main secondary structure of PrPc is α-helix while that of PrPsc is β pleac is α-helix while that of PrPsc is β pleated sheet.ted sheet.
PrPsc can convert the PrPc it meets to tPrPsc can convert the PrPc it meets to the malady-caused structure.he malady-caused structure.
PrPsc can be metabolic and will be storPrPsc can be metabolic and will be stored in the neuron of the brain then kill thed in the neuron of the brain then kill the cell.e cell.
If too many neurons are exterminated, tIf too many neurons are exterminated, the brain will lose it’s original function ahe brain will lose it’s original function and the symptons of the disease appearnd the symptons of the disease appears. s.
How Do Mad Cow Disease How Do Mad Cow Disease Spread?Spread?
In order to made cows grow better, people In order to made cows grow better, people mixed the powder of bones they got after mixed the powder of bones they got after slaughtering with feed.slaughtering with feed.
While making sheep bone powder, the prion While making sheep bone powder, the prion that caused scrapie was mixed with it and that caused scrapie was mixed with it and then eaten by cows.then eaten by cows.
Prion won’t be decomposed in the stomach Prion won’t be decomposed in the stomach and intestine, and will be absorbed and and intestine, and will be absorbed and transported into the brain.transported into the brain.
Diseases related to the Prion Diseases related to the Prion (TSEs)(TSEs)