Lymph node pathology
Dec 18, 2015
Lymph node pathology
Lymph node histology
FunctionsFiltration of lymphProcessing of AgDifferentiation of lymphocytes
Secondary lymphoid follicleGerminal centremantle
Terminology
• Lymphadenopathy
• Lymphadenomegaly
• Lymphadenitis
• Lymphoproliferation
• Lymphoma
• Enlargement of LN: inflammation
• Tumor – primary/secondary
Lymphadenitis
acute or chronic
Classification
predominant histologic pattern
etiology
Rarely biopsied
Lymphadenitis - etiologyMICROBIAL
• viral
• bacterial, mycobacterial
• fungal
• protozoal
NONMICROBIAL - autoimmune
storage dis.
foreign mat.
miscel.
Lymph node inflammation
Lymph node hyperplasia:
1. follicular
2. paracortical
3. sinuses
4. mixed patterns
Lymph node inflammation - patterns
• Follicular hyperplasia
bacteria, RA, HIV(early), syphilis,
Castleman dis.
• Paracortical hyperplasia
viruses, dermatopathies, vaccination,
drug hypersensitivity, Kikuchi, SLE,
draining pus or carcinoma
Lymphadenitis - histological patterns
• sinusoidal hyperplasia - lymphangiography, Whipple dis., sin. histiocytosis with massive lymphadenopathy, draining carcinoma
• granulomas - TB, other mycobact., leprosy, Whipple, fungi, berylliosis, sarcoidosis,
• Granulomatous-purulent:cat scratch, tularemia, lymphogr. venereum,Yersinia
• mixed patterns: toxoplasmosis
Regressive transformation of germinal centres
Follicular hyperplasia
Progressive transformation of germianl centres
Sinus histiocytosis
Lepra - globi
Infectious mononucleosis
Cat scratch disease
Kikuchi lymphadenitis
Bartonella henselaeCt scratch disease
CMV
Kimura disease
Cryptococcosis
Atypical mycobacteriosis
Lymphogranuloma venereum
Mycobacterium TB
Pneumocystosis
Syphilis
TBC
Toxoplasmosis
Whipple disease
Sinus histiocytosis with massive lymphadenopathy