Lung Flukes –Chapter 18, p. 281-285 Paragonimus westermani Oriental Lung Fluke is an important human parasite in the Orient (Japan, Korea, China, SE Asia), Pacific islands (Philippines), and India. It is occasionally found in western Africa and South America. ______________________ human cases It is occasionally found in western Africa and South America. Parasite is not endemic in North America.
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Lung Flukes –Chapter 18, p. 281-285Paragonimus westermani
Oriental Lung Fluke is an important human parasite in the Orient (Japan, Korea, China, SE Asia), Pacific islands (Philippines), and India. It is occasionally found in western Africa and South America.
______________________ human cases
It is occasionally found in western Africa and South America.
Parasite is not endemic in North America.
Paragonimus westermani
Recent cases have been identified in _________________________________ in Minnesota and Wisconsin.
Originally misdiagnosed as _________________________________, as the lung pathology mimics this disease.
Morphology of Adult Paragonimus westermani
Adults are 8-12 mm long x 4-6 mm wide; 3-5 mm thick.
_______________________ is lobed and located on one side of the _______________________
Egg-filled _____________________ is on opposite side of acetabulum.
Characteristic structure is the extensive _____________________ - extend from anterior end to posterior end.
________________________ are lobed and are located opposite each other in mid-posterior of body.
Morphology of Adult Paragonimus westermani
Life Cycle of Paragonimus westermani
DEFINITIVE HOSTS: Parasite shows low host specificity in that ____________________________ (primarily __________________________________) can serve as a definitive host.
- these hosts also serve as ________________________ for transmission to a human.
- thus, this parasite is a __________________________
Life Cycle of Paragonimus westermani
HABITAT: Adults live in ________________________
_____________________________________________
Life Cycle of Paragonimus westermani
1. Adults occur in pairs in the __________________________
2. __________________ are released into the bronchioles and move along the respiratory tree by ciliary action. They move into the bronchi trachea pharynx where they are:
1.
2.
Life Cycle of Paragonimus westermani
3. Eggs must be released into an aquatic habitat. _________________________ hatch and swim until they penetrate _______________________ first intermediate host.
4.Within the snail, sporocyst and redial generations occur.
Life Cycle of Paragonimus westermani
5. _______________________ _________________________ leave the snail and crawl along the pond bottom until they come in contact with a _________________________ (second intermediate host).
Life Cycle of Paragonimus westermani
6. Cercariae penetrate crab or crayfish and encyst in the muscles as _______________________
7. When crab or crayfish is eaten raw or poorly cooked, metacercariae excyst in the duodenum.
- The immature adults bore through the wall of the duodenum.
- They then ________________________ ________________________ and invade the lung bronchioles and are mature in 2-3 months.
Pathology of Paragonimus westermaniNormal bronchiole
ADULTS:
(1) bronchiolar epithelium thickens
(2) connective tissue capsules are formed around worms.
(3) these capsules often ulcerate causing hemorrhaging.
(4) fibrous connective (scar) tissue deposition occurs throughout the lungs.
Symptoms are difficulty in breathing, coughing, and bloody sputum.
• Infection often __________________________________and can be misdiagnosed
Pathology of Paragonimus westermani
IMMATURE ADULTS:
Migration of the immatures can be dangerous if the worms ________________________________and end up in ectopic sites such as the ________________________________ Fatalities may occur.
TREATMENT - _______________________________ is somewhat effective if lung damage is not too severe.
PREVENTION -
SPREAD DISEASE
Paragonimus kellicoti
Closely related species – identical to P. westermani
DEFINITIVE HOSTS– adults occur in wide variety of _____________________________ including ________________________________________________________________________________________________
- distributed in North America east of the Rocky Mountains
- parasite is enzootic in Wisconsin - commonly found in ________________________
Paragonimus kellicoti
LIFE CYCLE involves snails as first intermediate hosts and pond crayfish as second intermediate hosts.