LSC 2013 Barcelona

1 1 © 2009 PerkinElmer © 2009 PerkinElmer © 2009 PerkinElmer © 2012 PerkinElmer

Marleen Stomp-Smit

Staff Scientist LSC

Center of Excellence for LSC Cocktails and Vials

PerkinElmer Groningen, The Netherlands

Safer, NPE-free LSC Cocktails

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Introduction

Surfactants

NonylPhenolEthoxylates (NPE’s)

AlcoholEthoxylates (AE’s)

NPE replacement challenges

New NPE-free LSC cocktail formulations

Properties

Storage stability data

Customer evaluation

Presentation Outline

New developments in Liquid Scintillation instrumentation and reagents

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LSC cocktail composition

Aromatic solvent

Scintillators

Surfactants



LSC cocktail developments

Shift to safer solvents

Scintillators no change

NonylPhenolEthoxylate (NPE) surfactants recently scrutinized

Introduction


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Primarily used in domestic and industrial detergents

Effective surfactants in general

Good wetting agents, excellent emulsifying and dispersing properties

Storage and shipping classification in general

UN 3082, Environmentally Hazardous Substance

Biodegradation products endocrine disruptor (gender bender)

Decreasing availability

Gradual laundry industry phase out


Most common alternative for NPE’s

Less effective surfactants in general

Excellent wetting agents, moderate emulsifying and dispersing properties

Not classified as dangerous for storage and shipping

Expanding availability

Complete range

Surfactants


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Take advantage of the AE’s excellent wetting properties and simultaneously

minimize the impact of moderate emulsifying and dispersing properties

Combined surfactant system

AE range, Phosphate esters, Succinates.

AE’s impact on LSC cocktails

Counting properties

Efficiency, Sample Load Capacity

Possible 14C introduction

Fatty alcohol source

Possible 40K introduction

Reaction catalyst

AE’s suitable for LSC cocktails

Synthetic alcohol source

Sodium reaction catalyst

NPE replacement challenges


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Ultima Green

High-Flashpoint (Safer) NPE-free LSC Cocktail

Universal LSC cocktail

High counting efficiency

Quench resistent

Tritium (15µl Trititiated Hexadecane) Efficiency

10 ml Cocktail: 54,6%

10 ml Cocktail + 1 ml water: 49,3%

Background with NaOH

2 min count time

0,0-18,6 keV

New NPE-free LSC Cocktail formulations


3 ml 0,1M NaOH 3 ml 1,0M NaOH

2 min. 69 5653

15 min. 12 260

30 min. 15 97

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Ultima Green Sample Load capacity

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Aqua Green

High-Flashpoint (Safer) NPE-free LSC Cocktail

High aqueous sample load

Suitable for Low Level applications

Tritium (15µl Trititiated Hexadecane) Efficiency

10 ml Cocktail: 45,8%

10 ml Cocktail + 10 ml water: 20,8%

Low Level Background

120 min. Count time

Tri-Carb Low Level Mode

10 ml cocktail + 10 ml water



Insta-Gel Plus Aqua Green Ultima Gold LLT

0,5-5,0 keV 2,76 2,67 1,64

0-18,6 keV 5,09 5,00 2,84

20-1400 keV 6,32 3,13 2,87

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Aqua Green Sample Load capacity

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tSIE (Quench Parameter) used as indicator

Average tSIE decay for Safer LSC cocktails is about 30 units per year

Ultima Green

Storage at room temperature

December 2011 tSIE 628

January 2013 tSIE 581

Storage at 30°C

December 2011 tSIE 628

January 2013 tSIE 576



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Two months storage at 30°C, weekly measurements



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Two Safer, NPE-free LSC cocktails are developed

Customer feedback is greatly appreciated

Currently customer evaluation in progress

Qualify for beta testing at our booth!



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Safer, NPE-free LSC Cocktails


Thank you for your attention

Questions or remarks?

Please visit us at the PerkinElmer booth

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PerkinElmer Groningen LSC Cocktails and vials Production site

LSC 2013 Barcelona

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