Low-Toxin Clostridioides difficile RT027 Strains Exhibit Robust Virulence

Low-Toxin Clostridioides difficile RT027 Strains Exhibit Robust Virulence 1 2 Farhan Anwar 1 , Bryan Angelo P. Roxas 1 , Kareem W. Shehab 2 , Neil Ampel 3 , VK 3 Viswanathan 1,4,5 , and Gayatri Vedantam 1, 4, 5, 6 4 5 1 School of Animal and Comparative Biomedical Sciences, The University of Arizona, 6 Tucson, AZ, USA, 2 Department of Pediatrics, The University of Arizona College of 7 Medicine, Tucson, AZ, USA, 3 Mayo Clinic, Phoenix, AZ, 4 Department of Immunobiology, 8 The University of Arizona College of Medicine, Tucson, AZ, USA, 5 BIO5 Institute for 9 Collaborative Research, The University of Arizona, Tucson, AZ, 6 Southern Arizona VA 10 Healthcare System, Tucson, AZ 4 . 11 12 *Correspondence to: 13 Gayatri Vedantam, Ph.D. 14 University of Arizona 15 School of Animal & Comparative Biomedical Sciences 16 1117 E. Lowell St. Bldg. 90 17 Tucson, AZ 85721 18 Phone: 520-626-6839 19 gayatri@ arizona.edu 20 21 22 (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprint this version posted March 19, 2022. ; https://doi.org/10.1101/2022.03.18.484943 doi: bioRxiv preprint

Low-Toxin Clostridioides difficile RT027 Strains Exhibit Robust Virulence

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