Long Term Verification Long Term Verification of Glucose-Insulin of Glucose-Insulin Regulatory System Regulatory System Model Dynamics Model Dynamics THE 26th ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY J. Lin, J. G. Chase, G. M. Shaw, T. F. Lotz, C. E. Hann, C. V. Doran, D. S. Lee Department of Mechanical Engineering University of Canterbury Christchurch, New Zealand
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Long Term Verification of Glucose-Insulin Regulatory System Model Dynamics THE 26th ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE.
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Long Term Verification Long Term Verification of Glucose-Insulin of Glucose-Insulin Regulatory System Regulatory System
Model DynamicsModel DynamicsTHE 26th ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE
ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY
J. Lin, J. G. Chase, G. M. Shaw, T. F. Lotz,C. E. Hann, C. V. Doran, D. S. Lee
Department of Mechanical EngineeringUniversity of Canterbury
Christchurch, New Zealand
Hyperglycemia in the ICUHyperglycemia in the ICU
• Stress-induced hyperglycemia
• Insulin resistance or
deficiency enhanced
• High dextrose feeds don’t suppress glucagon release or gluconeogenesis
• Drug therapy
Source: www.endocrine.com
There is a need for validatedModels to aid treatment
Physiological ModelPhysiological Model
Blood PlasmaThe utilisation of insulin and the removal of glucose over time
LiverProduces endogenous glucose (GE)
Exogenous Glucose
Food intake etc. (P(t))
Exogenous InsulinInsulin injection etc. (uex(t))
PancreasProduces endogenous insulin I(t)
GE P(t)
G
)(1
)( tPQ
QGGSGpG
GEIG
t tk deIkQ
0
)()(
I
Btu
II V
Ie
V
tu
I
nII
)()(
1
Glucose DynamicsGlucose Dynamics
The ability to regulate blood glucose level
Tissue sensitivity to insulin
Blood PlasmaThe utilisation of insulin and the removal of glucose over time