Long-term Cardiac Arrhythmias recorded by an Insertable Loop Recorder in Patients with Depressed Left Ventricular Function after Acute Myocardial Infarction CARISMA Cardiac Arrhythmias and RIsk Stratification after Myocardial infArction PE Bloch Thomsen,MD,PhD Gentofte University Hospital Copenhagen, Denmark pebt@ geh.regionh.dk
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Long-term Cardiac Arrhythmias recorded by an Insertable Loop Recorder in Patients with Depressed Left Ventricular Function after Acute Myocardial Infarction.
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Long-term Cardiac Arrhythmias recorded by an Insertable Loop Recorder in Patients with
Depressed Left Ventricular Function after Acute Myocardial Infarction
CARISMACardiac Arrhythmias and RIsk Stratification after Myocardial infArction
PE Bloch Thomsen,MD,PhD Gentofte University Hospital
Copenhagen, Denmarkpebt@ geh.regionh.dk
CARISMA investigators
Principal investigators: H. Huikuri, Finland, PE Bloch Thomsen, Denmark
P. Raatikainen University of Oulu, FinlandR.M. Joergensen University of Copenhagen, Denmark J. Hartikainen University of Kuopio, FinlandV. Virtanen University of Tampere, FinlandJ. Boland Hopital Citadelle, Liège, BelgiumO. Anttonen Paijat-Hame Hospital, Lahti, FinlandL.A.V. Boersma St. Antonius Hospital, Nieuwegein,
NetherlandsE.S. Platou University of Oslo, NorwayE. Stoupel Hopital Erasme, Brussels, BelgiumJ. Rokkedal, N. Hoest Amtssygehuset Glostrup, Denmark
European multicenter, prospective, observational study
Disclosures
Research grant and speaker fee • Boston Scientific Guidant
• Medtronic BRC • St. Jude Medical
CARISMA was sponsored by
• Medtronic Bakken Research Center
• Cambridge Heart Inc
Assess the predictive value of
electrophysiologic testing and
non-invasive screening tests for
life-threatening tachyarrhythmias in
patients surviving AMI with EF ≤ 0.40
CARISMA – Objective 1
(HRS, Hot Line Session, Denver, May 10, 2007)
CARISMA – Objective 2
Document the incidence and assess
the prognostic significance of cardiac
arrhythmias obtained from an
implantable ECG loop recorder
Implantable loop recorder
Weight 1/2 oz, 8 cc. Longevity up to 2 years. ECG storage 42 min, automatic arrhythmia detection algorithms
Sampling rate 100 Hz
Inclusion criteria
• Patients within 3 to 21 days of AMI + CKMB or Troponin elevation+ Typical chest pain or ECG changes