4100607400 Rev 0.1 Speed. Versatility. Quality. Nov, 2012 May Lee Global Product Management Long Pulsed Alexandrite & Nd:YAG Laser
4100607400 Rev 0.1
Speed. Versatility. Quality.
Nov, 2012
May Lee
Global Product Management
Long Pulsed Alexandrite & Nd:YAG Laser
Worldwide Revenue by Indication
Source: Global Aesthetic Market IX Report published by Medical Insight, Inc., Jan 2012
Source: Global Aesthetic Market IX Report published by Medical Insight, Inc., Jan 2012
Worldwide Procedure Fees by Indication
LASER-TISSUE ABSORPTION SPECTRUM
Oxyhemoglobin Deoxyhemoglobin Melanin Water
755 nm 805 nm
1064 nm
694 nm
* Dr. David Vasily, ASLMS 2012 Presentation on Hair Removal Lasers
Comparison of Melanin Absorption* •532 nm YAG : Higher absorption for melanin and oxyhemo, but limited penetration •755 nm alexandrite: higher melanin and oxyhemo absorption than 810 nm diode •1064 nm : deeper penetration, absorbed by oxyhemo, higher absorption for water
Hair Removal
Pigmented Lesions
Vascular Lesions
Skin Rejuvenation/Lifting
532 nm
MARKET SIZE & HIGHEST GROWTH POTENTIAL: PIGMENTED LESION
Source: BCG Research - MEDICAL LASERS: TECHNOLOGIES AND GLOBAL MARKETS, January 2010.
• Worldwide Pigmented Lesion Removal market is expected $207 mil in 2014 with highest growth rate 20.5% by year
Huge Opportunity for Hair Removal in 2012 - $266M
Source: Global Aesthetic Market IX Report published by Medical Insight, Inc., Feb 2012.
6
Alexandrite Laser demonstrates the superiority for Hair Removal.
Biggest advantage of long pulsed Nd:YAG laser is that they usually work on all types of skin, even on tanned skin in particular, and on darker skin.
Market Needs for Multiple Application Platform Europe Distributor Comments
• Candela and Cynosure introduced combination systems with Alexandrite and long pulsed Nd:YAG with an attractive pricing strategy. The dermatologists who favor treating multiple applications with one system preferred this type of system.
Source from European distributors, 2011
INDICATIONS PREFERRED BY EACH REGION FOR LONG PULSED ALEXANDRITE LASER
Source: Inputs from distributors and regional sales team, initial marketing survey, 2011-2012
•Hair Removal •Skin Rejuvenation •Pigment •Vascular •Pigment
•Skin Rejuvenation •Hair Removal •Vascular
•Hair Removal •Skin Rejuvenation •Pigment •Vascular
TESTIMONIALS FOR ALEXANDRITE FROM KOREAN KOLS
• “Alex is very effective for removal of lentingines, moles and SK. There is no bleeding, no crust. Furthermore the patients can wash their face right after the treatment. Also, it’s good for Photorejuvenation. Generally Wrinkles, pores or pigmented disorders, and so on. have been treated with different lasers but the Alexandrite can improve them all together. One treatment will not be sufficient, but after 4~6 weeks you will recognize the difference. It is also very effective for hair removal and hemangiomas.”
Dr.KT Hong, Dermatologist, Yonsei Modern Clinic, South Korea
• Alexandrite can treat pigment disease better than Nd:YAG which is better for vessel disease. Alex is popular for hair removal or pigment disease whereas overseas it is used for blood vessel disease and hair removal in Korea
• Lutronic needs the system to complete their line up for the aesthetic market. There is constant demand for the device not only in Korea, but also in the global market.
Dr.SJ Lee, Dermatologist, Yonsei Star Clinic, South Korea
Introduction
The CLARITY Family
• CLARITY LPA: Alex only • CLARITY LPY: YAG only • CLARITY LPC: Alex + YAG Combo
The choice of Cryo ICD or air cooling is available
Cryogen ICD canister
0.5 - 10 Hz
2, 3, 5, 8, 10, 12, 15, 18, 20 mm
Cryo ICD or Air Cooling*
CLARITY™ Specification
* User selected, engineer installed
Cryogen ICD canister
Air Hose connector
“U” Tip of AC model
“O” Tip of ICD model
CLARITY™ Flat Top Beam Profile at 755 nm
Source: Lutronic R&D measured. Photograph by Beam Profiler (Gentec,“Beamage”), 2012
CLARITY™ Flat Top Beam Profile at 1064 nm
Source: Lutronic R&D measured. Photograph by Beam Profiler (Gentec,“Beamage”), 2012
CLARITYTM User Friendly GUI
CLARITY™ FEATURES & BENEFITS
Rapid Treatment
Up to 2 Hz at 18 mm spot, 1.5 Hz at 20 mm for fast hair removal. Better staff efficiency, improved profit potential
Single Fiber Delivery for All Spot Sizes
2 to 20 mm spot sizes are available with single fiber delivery, providing convenience, saving treatment time and costs.
Wide Range Enhanced Parameter
Unique feature of CLARITY: Lower fluence is available at a smaller spot size for gentle pigment removal.
• Largest spot size: Up to 20 mm
• High repetition rate: Up to 2 Hz at 18 mm, 1.5 Hz at 20 mm for faster hair removal
• Time efficiency: Shorter treatment times for larger areas increases the clinic’s ROI
15 mm
18 mm
20 mm
CLARITYTM Faster Treatment Speeds
2mm
CLARITYTM Wide Range of Spot Sizes
Spot Size Auto-sensing
• Dual wavelength platform offers greater versatility
• Wide range of pulse widths and spot sizes for both Alex & YAG (NO limitation by wavelength)
- supports treatment convenience for a variety of indications and skin types in actual practical clinical conditions
Higher efficacy in fine hair removal with shorter pulse widths from the Alex
- Unique feature of CLARITY: lower fluence is available at a smaller spot size for gentle pigment removal
CLARITYTM Enhanced Parameters
Indication Laser Pulse Width
Hair Removal* Alex Fine: 3 ~ 5 ms Medium: 3 ~ 5 ms Thick: 5 ~ 20 ms
YAG Fine: 5 ~ 12 ms Medium: 12 ~ 40 ms Thick: 20 ~ 40 ms
Pigment* Alex 0.35 ~ 3 ms
Vascular* Alex 3 ~ 20 ms
YAG 5 ~ 60 ms
Rejuvenation Lifting
Alex 0.5 ~ 3 ms
YAG Quatro Technique: 0.35 ~ 1ms InnerLift Technique: 12 ~ 20 ms Standard Technique: 50 ~ 70 ms
CLARITYTM Wide Range of Pulse Widths by Indication
* CE marked indications
• 2 to 20 mm spots sizes are available with a single fiber delivery system
• Convenient for physicians: minimizes the treatment time, time because there is no need to change fiber during the procedure
• No need buy an optional fiber for smaller spot sizes
CLARITYTM Single Fiber Delivery for ALL Spot Sizes
Ergonomically designed fiber pole set: Automatic locks and holds the fiber without slipping
• Choice of Air Cooling or Cryogen ICD Cooling type
• ICD = Intelligent Cooling DeviceTM - Built-in cooling system
- Save time, save space
- Effective and consistent cooling during procedures
• Air Cooling - No consumables, but needs an external air cooler
- Continuously cools the epidermis throughout treatment
• An engineer is required to change the cooling method
* User selected, engineer installed
CLARITYTM User-Selectable Cooling System
CLARITYTM Memory Function: 64 Memories by Wavelength
CLARITYTM User Controlled Calibration
CLARITYTM PHYSICIAN’S TESTIMONIAL
Chong-Hyun Won, MD Dermatologist, South Korea
“ CLARITY long pulsed 755 nm Alexandrite is very effective for various pigment and photo rejuvenation without crust. Generally wrinkles, pores or skin laxity can be improved all together with this dual wavelength workhorse. Advanced features of CLARITY provides multiple treatment technique for combination. I prefer speedy hair removal feature of CLARITY, it is really efficient for fine hair removal.”
CLARITYTM Alexandrite Pigment Treatment
TWIN Technique: • Small spot focus • Large spot scanning
CLARITYTM NEW Lifting Technique with the Nd:YAG
•QuatroTM Technique
•InnerLiftTM Technique
Comfortable
No Aensthetics
Speedy Procedure
Easy combination
Post Cooling Only
CLARITYTM Hair Removal with the Alex or Nd:YAG
The chromophores for the 755 nm or 1064 nm laser are • Melanin in the hair and follicle • Stem cells in the bulge • The blood supply in the papilla
Bulge
Bulb
Underside of D-E junction
Root & papilla
Subdermal fatty layer
• Selectively absorbed in the laser chromophores in the hairs and follicles, selectively heating and destroying. • The blood supply to the hair root is disrupted, the stem cells in the bulge are damaged, and the hair is forced into prolonged catagen and telogen phases, resulting in long-term hair removal.
CLARITYTM Vascular Treatment with the Alex or Nd:YAG Laser
SKIN TONE & TEXTURE IMPROVEMENT WITH ALEX
Courtesy of J.H.Won, MD, South Korea
After Before
PIGMENT REMOVAL WITH ALEX
Courtesy of B.L.Goo, MD, South Korea
After Before
PIGMENT REMOVAL WITH ALEX
After Before
Courtesy of J.H.Won, MD, South Korea
HAIR REMOVAL WITH ALEX
Courtesy of J.H.Won, MD, South Korea
After Before
HAIR REMOVAL WITH ALEX
Courtesy of J.H.Won, MD, South Korea
After Before
VASCULAR LESION WITH ALEX
Courtesy of B.L.Goo, MD, South Korea
After Before
– June, 2012 (LPC/LPA/LPY, with ICD/air cooling as optional)
– March, 2012 (LPC/LPA/LPY, with ICD/air cooling as optional)
CLARITY CLEARANCES
– TBD
– Est.Q2, 2013
CLARITY CE Mark
CLARITYTM Ad / e-Blast
CLARITYTM Ad: Medical S, Korea
CLARITYTM Brochure
• Planned & In Process
– Patient brochure: Oct, 2012 (KR)
– Marketing video: 3D animation by indication
CLARITYTM Marketing Tools:
• Planned & In Process
– Pilot Study of Dosimetry by indication: May 2012, Ongoing
– Clinical Studies: May 2012, Ongoing (T) Peer-reviewed Publication (est.2013)
– Market Preference Evaluations: July 2012, Ongoing
– Customized editorials: Q4 2012 (Asia Pacific)
– White Papers: Q4 2012
– Clinical Roundtables: Q1 2013
– Laminated Clinical Guide: Q3 2012
– eSeminar/Workshop: Q3 2012
CLARITYTM Clinical Validation Tools:
CLARITYTM Laminated Clinical Guide
CLARITY
Manufacturer Lutronic
Model name Elite MPX
Cynosure
GentleMax/Pro
Candela.
Synchro PLA:Y
DEKA
Laser Type Long pulsed Alexandrite (755 nm) / Nd:YAG (1064 nm) Laser
Pulse
Width(Alex) 0.35~300 msec 0.5~300msec 0.25~300msec 2~100msec
Spot Size
(Alex)
2/3/5/8/10/12/15/
18/20 5/7/10/12/15/18mm
6/8/10/12/15/18mm
1.5/3mm
5/10/12/14/15/16
mm
Pulse Rate Up to 10 Hz Up to 5 Hz Up to 10 Hz
Skin Cooling Air Cooling / ICD Air cooling Cyro DCD Cooling Air Cooling
Emission
Control Finger Switch or Foot Switch
CLARITYTM Comparison Table
Pulse Energy Up to 100 J (YAG)
Up to 55 J (Alex)
Up to 70J (YAG)
Up to 55J (Alex) Up to 53J (Alex) Up to 35J (Alex)
Up to 2 Hz
Specifications
Lasing Medium LP 755 Alex / 1064 Nd:YAG Combo Max.Pulse Energy (On time) 53J (Alex) Fluence Up to 150 J/cm2 Pulse Width 0.25 ms - 300 ms Spot Size 1.5, 3, 6, 8, 10, 12, 15, 18 mm
Fiber 6 - 18 mm fiber as standard 1.5 - 3 mm fiber as optional
Rep Rate Up to 10 Hz ( Up to 2 Hz at 18 mm)
Cooling Cryo DCD
(Air cooling compatible H/P is available at Pro)
Calibration External
Electrical 200 - 240V, 50/60Hz, 30A,
4600 VA single phage Weight 155.5kg /118 kg (Pro) Size 45 x 26.5 x 38 in. (114 x 67 x 97 cm) Warranty 1Yr (Lamp life span: 250,000) Price to physician List $134,9000 to $200,000 Consumables Cryo, Lenses, Distance tips
KEY COMPETITOR: CANDELA GENTLEMAX/PRO
Air cooling compatible H/P
Pros:
•Up 2 Hz at18 mm spot size
•Wide range of pulse width
•Rapid treatment
•High brand recognition
KEY COMPETITOR: CANDELA GENTLEMAX
Cons:
•Need to change fiber for small spot size (1,5, 3 mm), additional cost and longer treatment time
•Higher minimum fluence at small spot size, not proper for pigment removal
•Not portable, very heavy system
•DCD gas loss
•Heavy service burden & expensive
•Consumable Expense (distance tips, cryo, service)
•Expensive product
Specifications
Lasing Medium LP 755 Alex/1064 Nd: YAG Combo Max.Pulse Energy (On time)
55 J (Alex) 70 J (Nd:YAG)
Fluence Up to 150 J/cm2
Pulse Width 0.5 - 300ms (Alex)/0.4 – 300 ms(Nd:YAG)
(10 - 40 ms at Multiplex)
Spot Size 5, 7, 10, 12, 15, 18 mm (Alex)
1.5,3,5,7,10,12,15,18 mm (Nd:YAG)
Rep Rate Up to 3 Hz (Alex)/5 Hz (Nd:YAG)
( Up to 1 Hz at 44J, ~5ms) Cooling Air Cooling Calibration YES Electrical 200/220V, 50/60Hz, 30A, single phage Weight 82 kg (Elite) Size 46 x 17.25 x 32.4 in. (116.8 x 43.8 x 82.3 cm)
Warranty 1Yr Price to physician Consumables NO
KEY COMPETITOR: CYNOSURE ELITE/MPX
Pros:
•No consumables
•MPX feature: blending of Alex and YAG
•Brand recognition
KEY COMPETITOR: CYNOSURE ELITE/MPX
Cons:
•Air cooling only
•Min.spot size is 5 mm in Alex mode
•1.5 mm spot size is optional
•Up to 2 Hz in Alex mode for hair removal
(MPX)
•Red aiming beam
•MPX feature not proven to be more
effective in clinical trials – ALL MARKETING
HYPE
KEY COMPETITOR: DEKA SYNCHRO PLA:Y
Specifications
Lasing Medium LP 755 Alex/1064 Nd: YAG Combo Max.Pulse Energy (On time) 35 J (Alex)
Fluence Up to 500 J/cm2 (YAG) Up to 60 J/cm2 (Alex)
Pulse Width 2 – 100 ms (Alex)
0.3 – 300 ms (Nd:YAG)
Spot Size 5, 10, 12, 14, 15, 16 mm (Alex)
2.5, 5, 7, 10, 14, 15 mm(Nd:YAG)
Rep Rate Up to 2 Hz (Alex)
Up to 7 Hz (Nd:YAG) Cooling Contact cooling Calibration External? Electrical 230V, 16A Weight 155.45 kg Size 900(H) x 480(W) x 850(D) mm Warranty 1Yr (Lamp life span:) Price to physician List $ Consumables NO
Pros:
•No consumables
•Optional IPL
•Relative inexpensive
KEY COMPETITOR: DEKA SYNCHRO PLA:Y
Cons:
•Poor beam quality and stability
•Air cooling only
•2 to 100 ms pulse with in Alex mode: no
shorter and longer pulse with as others
•Maximum spot size is only 16 mm
•Minimum spot size is 5 mm in Alex mode
•Limited pulse rate: max. 2 Hz only