TM Drug Delivery Embolisation System for PRECISION TACE 140 120 100 80 60 40 20 0 100-300 300-500 500-700 700-900 SIZE (microns) TIME (mins) • A dose of up to 37.5mg Doxorubicin per ml DC Bead TM can be loaded. • The maximum recommended total dose of Doxorubicin per procedure is 150mg. 1 Reconstitute a vial containing 50mg of Doxorubicin with 2ml of sterile water for injection. Mix well to obtain a clear solution (25mg/ml). 3 Using a syringe and needle add the 2ml of reconstituted Doxorubicin solution directly to the vial of DC Bead TM . Label Nominal Volume Product Colour Bead Size of Beads Code Yellow 100 – 300 µm 2ml DC2V103 Blue 300 – 500 µm 2ml DC2V305 Red 500 – 700 µm 2ml DC2V507 Green 700 – 900 µm 2ml DC2V709 2 Remove as much saline as possible from a vial of DC Bead TM using a syringe with a small gauge needle. 4 Agitate the DC Bead TM /Doxorubicin solution gently to encourage mixing then allow to stand until the beads are red and the solution is almost colourless. LOADING INSTRUCTIONS 5 Loading will take a minimum of 20 minutes for the smallest size DC Bead TM and up to 120 minutes for the largest size DC Bead TM . 6 Prior to use, transfer the beads loaded with Doxorubicin to a syringe and add an equal volume of non- ionic contrast media. Invert the syringe gently to obtain an even suspension of beads. Less More Every time DC Bead™ is a trademark of Biocompatibles UK Ltd EC302 © 2005 Biocompatibles UK Ltd