LKT Laboratories, Inc. - Sapphire Bioscience

Antiangiogenic CompoundsAntimicrobialsApoptosis InducersBiologically Active PeptidesCancer Chemopreventive AgentsChemotherapeuticsDrug Discovery KitsNatural ProductsSignal Transduction Chemicals

LKT Laboratories, Inc.

Specialty Chem

icals For Life Science Research 2012-2014

LKT Laboratories, Inc.545 Phalen Blvd.St. Paul, MN 55130-5303

Tel: 651-644-8424Toll Free Tel: 888-558-5227Fax: 651-644-8357Toll Free Fax: 888-558-7329Web: www.lktlabs.com

Shenzhen Minn Bolin Bio-Tech Co., Ltd.A-22J, Xinhe-Aiqinju Building,No. 303, Shenhui RoadBuji, Longgang District,Shenzhen 518112, ChinaTel: 86-755-2510-6053Fax: 86-755-2510-6053Web: www.mbolin-lktlabs.com/cnEmail: [email protected]

International Distributors:(more distributors listed on the inside back cover)

Wako Pure Chemical Ind. Ltd.1-2, Doshomachi 3-ChomeChuo-Ku, Osaka 540-8964, JapanTel: +81-6-6203-3741Fax: +81-6-6201-5964Web: www.wako-chem.co.jpEmail: [email protected]

Biomol GmbHWaidmannstr. 3522769 Hamburg, GermanyTel: +49-40-85 32 600Fax: +49-40-85 32 60 22Web: www.biomol.deEmail: [email protected]

2012-2014 Catalog

LKT Labs is a research company focused on the discovery of specialty chemicals for can-cer chemoprevention. We produce and distribute unique chemicals and biochemicals for all types of life science research and supply raw materials for manufacturing and repacking.

PRICING, TERMS, AND SPECIFICATIONS

Prices and specifications shown are current at the time of printing. We make every effort to retain these prices and specifications until the printing of our next catalog; however, prices and specifications are subject to change without notice. All prices are in US dollars. LKT ships orders F.O.B, St. Paul, MN, USA. Payment terms are Net 30 Days from the date of invoice. LKT accepts Visa, Master Card, and Discover. Sales, use, excise and other applicable taxes will be charged.

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USE OF PRODUCTS

LKT’s products are intended solely for laboratory research purposes and are not to be used for any other purposes. Buyer acknowledges that the products have not been tested by LKT for safety or efficacy. Buyer expressly represents and warrants to LKT that Buyer will properly test, use, manufacture and market any products purchased from LKT and/or materials pro-duced with products purchased from LKT in accordance with the practices of a reasonable person who is an expert in the field and in strict compliance with all applicable laws and

regulations, now and hereinafter enacted. Buyer has responsibility to verify the hazards and to conduct any further research necessary to learn the hazards involved in using products purchased from LKT Buyer also has the duty to warn Buyer’s customers and any auxiliary personnel (such as freight handlers, etc) of any risks involved in using or handling the products. Buyer agrees to comply with instructions, if any, furnished by LKT relating to the use of the products and not misuse the products in any manner. If the products purchased from LKT are to be repackaged, relabeled or used as starting mate-rial or components of other products, Buyer will verify LKT’s assay of the products. No products purchased from LKT shall be considered to be foods, drugs, medical devices or cosmetics.

WARRANTIES AND DISCLAIMERSLKT warrants that its products shall conform to the description of such products as pro-vided by LKT through LKT’s catalog, analytical data or other literature. This warranty is exclusive, and LKT makes no other warranty, express or implied, including any implied warranty of merchantability or fitness for any particular purpose.

LKT’s sole and exclusive liability and Buyer’s exclusive remedy with respect to products proved to LKT’s satisfaction to be defective or nonconforming shall be replacement of such products without charge or refund of the purchase price, at LKT's sole discretion, upon the return of such products in accordance with LKT’s instructions. LKT shall not in any event be liable for incidental, consequential or special damages of any kind resulting from any use or failure of the products. This limitation expressly includes but is not lim-ited to, damages to a third party occasioned by such product. All claims must be brought within 60 days after receipt of the material by the Buyer, regardless of their nature.

RETURN POLICYContact our Customer Service Department for a Return Authorization within 30 days for replacement of any product sold by LKT Labs that does not meet the standards indicated by the product specification.

ORDERING INFORMATION

Phone: (651) 644-8424 (888) 558-5227

Fax: (651) 644-8357 (888) 558-7329

Location: LKT Laboratories, Inc. 545 Phalen Blvd. St. Paul, Minnesota 55130

Email: [email protected] Web: www.lktlabs.com

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Table of Contents

Bicalutamide ............................... 3

Bleomycins .................................. 3

Carboplatin ................................. 4

Cisplatin ....................................... 4

Carmustine .................................. 4

Cyclophosphamide ..................... 4

Gemcitabine Hydrochloride ..... 5

Acetoxychavicol Acetate ............ 5

Paclitaxel ...................................... 6

Acivicin ........................................ 6

Sulforaphane ............................... 7

Isothiocyanates ........................... 8

Cysteine Conjugates ................... 8

Ginsenosides ............................... 9

Hydroxytamoxifen ................... 10

Caffeic Acid Esters .................... 10

Indoles ........................................ 11

Organosulfur Compounds ...... 11

Selenium Compounds ............. 12

Coffee Compounds .................. 12

Lycopene .................................... 13

Resveratrol ................................. 13

Flavonoids ................................. 14

Formononetin ........................... 14

Icariin ......................................... 15

Wogonin .................................... 15

Fluoroquinolones ..................... 16

Conazoles .................................. 16

Flufenamic Acids ...................... 17

Cyclooxygenase-II Inhibitors .. 17

Glitazones .................................. 18

Sulindac ..................................... 18

Apoptosis Inhibitors ................. 18

Aconitine ................................... 19

Cyclosporins .............................. 19

Fluoxetine Hydrochloride ....... 20

Zonisamide ................................ 20

Acetylcholine Receptor Blockers 21

GABA Related Compounds .... 21

Aflatoxins ................................... 22

Marine Natural Products ......... 22

Protein Kinase Inhibitors ........ 23

Cyclopamine ............................. 23

Signal Transduction ................. 24

Clenbuterol Hydrochloride ..... 24

ACE Inhibitors .......................... 25

Perindopril ................................ 25

Mycophenolic Acid .................. 26

Statins ......................................... 26

Bisphosphonates ....................... 27

Proton Pump Inhibitors........... 27

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New Products List .......................................................................................................................................................33-34

Alphabetical Listing of our Specialty Chemicals ....................................................................................................37-269

Drug Discovery Kits .......................................................................................................................................... 271-279

Categorized Specialty Chemicals ..........................................................................................................................281-315

Index ........................................................................................................................................................................316-335

Featured Products ...........................................................................................................................................................3

Services ............................................................................................................................................................................28

Analytical Services ................................................................................................................................................28

Natural Product Isolation .....................................................................................................................................28

Custom Synthesis ..................................................................................................................................................28

Featured New Products .........................................................................................................................................29-32

Kinase Inhibitors ....................................................29PARP Inhibitors ......................................................30Histone Deacetylase Inhibitors .............................30Fasudil Hydrochloride ...........................................31

Marine Toxins .........................................................31Tigecycline ...............................................................32Psoralen ...................................................................32

Antineoplastics

BicalutamideBicalutamide (B3209), an analogue

of Flutamide (F4680), is a nonsteroidal antiandrogen. It is used as monother-apy or in combination with castration for prostate cancer.1 Bicalutamide in-terferes with androgen receptor-me-diated cell survival and initiates cell death in human prostate cancer cells by acting on components downstream of decline of DeltaPsim and upstream of cytochrome c release.2

Growth factors such as insulin growth factor (IGF-1), keratinocyte growth factor (KGF) and epidermal growth factor (EGF) can directly acti-

vate the androgen receptor in the ab-sence of androgen. Bicalutamide

is shown to completely inhibit androgen receptor activation

by EGF, IGF-1 and KGF in LnCaP cell lines. Because aberrant activation of the androgen receptor is one of the mecha-nisms involved in the late stage of pros-tate cancer, this finding may be impor-tant in androgen-independent prostate cancer, its final stage.3,4

Bicalutamide is a racemate and the (R)-enantiomer is exclusively respon-sible for its antiandrogenic activity. The plasma elimination half-life of (R)-Bicalutamide (B3210) is one week. The metabolism of (R)-Bicalutamide is essentially mediated by cytochrome P450.5

1. Schellhammer PF, Davis JW. Clin. Prostate Canc. 2(4):213-219 (2004). 2. Lee EC, Zhan P, et al. Cell Death & Differ. 10(7):761-771 (2003). 3. Culig Z, Hobisch A, et al. Cancer Res. 54(20):5474-7478 (1994). 4. Prostate Cancer Research Institute. www.prostate-cancer.org 5. Cockshott ID. Clin Pharmacokinet. 43(13):855-878 (2004).

BleomycinsBleomycins are glycopeptide-de-

rived natural products that exhibit potent antineoplastic and antibi-otic properties. Bleomycin sulfate (B4518) is the predominant com-ponent of the commercial Bleo-mycin. It is used to treat cervical, vulvar, testicular, penile, head, and neck carcinomas. It is also used in the treatment of hodgkins and non-hodgkins lymphomas. Although the exact mechanism of bleomycin is not known, its target is thought to be a nucleic acid.1

Bleomycin has two major struc-tural domains, the bithiazole DNA interaction site and a metal coordi-nation site.1 A complex of O2-Fe(III)bleomycin is formed at this site.2 This

generates an activated oxygen spe-cies that causes DNA degradation.2 When acting on intact cells the drug induces double and single strand breaks and inhibits DNA synthesis.3

Bleomycin A5 HCl (A4517 Ping-yangmycin) can induce two modes of cell death; necrosis, and apopto-sis. It is a useful chemotherapeutic drug to treat various cancers. In ad-dition, pingyangmycin can effective-ly treat venous malformations, nasal polyposis, and eyelid xanthelasma by inhibiting cell proliferation.4

1. Benitz-Bribiesca L, Sanchez-Suarez P. Ann. N.Y. Acad. Sci. 887:133-149 (1999). 2. Sugiura Y, Suzuki T, Otsuka M, et al. J. Biol. Chem. 258(2):1328-1336 (1983). 3. Gunther R, Forrest B, Newman W, et al. Acta Biochim. Pol. 45(1):13-18 (1998). 4. Yang LC, Yang SH, Tai KW, Chou MY, Yang JJ. J. Oral. Pathol. Med. 33: 37-45 (2004).

Bleomycin is produced by the bacterium Streptomyces verticillus

Formalin fixed paraffin embedded human prostate stained with Adrogen Receptor antibody

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Featured Products

Antineoplastics

CarboplatinCarboplatin (C0171), also known

by the brand names paraplatin or paraplatin-AQ, is an anti-tumor plati-num complex. The drug forms the major adduct 1,3-d (GXG) intrastrand cross link.1 It also forms interstrand cross links,2 which evidence suggests can cause more lethal lesions to the DNA strand.3

Carboplatin is quite similar to its parent compound cisplatin, “but with substantially less deleterious side ef-fects in treated patients with cispla-tin.”4

1.Teuben JM, Bauer C, Wang AH, Reedijik J. Biochemistry 38(38):12305-12312 (1999). 2.Pratt WB, Ruddon RW, Ensminger WD, Maybaum J. The Anticancer Drugs. Oxford University Press (1994). 3.Lawley PD, Philips DH. Mutat. Res. 355(1-2):13-40 (1996).4. Overbeck TL, Knight JM, Beck DJ. Mutat. Res. 362:249-259 (1996).

CisplatinCisplatin (C3374), produces inter-

strand DNA cross links.1 DNA distor-tions like location of the platinum res-idue in the minor groove, the bending of the helix towards the minor groove and large DNA unwinding are caused by interstrand cross links.2

Although there is no clear evidence which one of the DNA cross links are responsible for the cytotoxicity of the compound, there are suggestions that interstrand cross links can cause more lethal lesions.3 Cisplatin is used in the treatment of various types of cancer.

1. Teuben JM, Bauer C, Wang AH, Reedijik J. Biochemistry 38(38):12305-12312 (1999).

2. Malinge JM, Giraud-panis MJ, Leng M. J. Inorg. Biochem. 77(1-2):23-29 (1999).

3. Lawley PD, Philips DH, Mutat. Res. 355(1-2):13-40 (1996).

CarmustineCarmustine (C0173) is used to

treat certain types of brain cancer.1,2 Carmustine, also known as BCNU, is an alkylating and carbamoylating nitrosourea compound. It interferes with the growth of cancer cells to the point of destruction. Carmustine interacts with DNA, RNA and pro-teins5 causing DNA interstrand cross linking which is cytotoxic and leads to apoptotic cell death.3,4

1. Kokkinakis DM, Moschel RC, Pegg AE, Schold SC. Clin. Cancer Res. 5(11):3676-3681 (1999). 2. Wang CC, Li J, Teo CS, Lee T. J. Controlled Release 61(1-2):21-41 (1999). 3. Hickman MJ, Samson LD, Proc. Natl. Acad. Sci. U. S. A. 96(19):10764-10769 (1999). 4. Meikrantz W, Bergom MA, Memisoglu A, Samson L. Carcinogenesis 19(2):369-372 (1998). 5. Pratt WB, Ruddon RW, et al. The Anticancer Drugs. Oxford Uniniversity Press (1994).

CyclophosphamideCyclophosphamide (C9606) is

the most commonly used alkylat-ing agent with broad application in cancer chemotherapy. The drug is activated by liver cytochrome P-450 (CYP) via 4-hydroxylation to pro-duce the cytotoxic alkylating mustard phosphoramide.1 Like other nitrogen mustards, cyclophosphamide exerts its antitumor activity by causing DNA strand cross links and inhibiting DNA replication in proliferating cancer cells.2 It is also used for the treatment of rheumatoid arthritis.3

1. Roy P, Yu LJ, Crespi CL, Waxman DJ. Drug Metab Dispos, 27:655-266 (1999).

2. Pratt WB, Ruddon RW, et al. The Anticancer Drugs. Oxford University Press (1994).

3. Cron RQ, Sharma S, Sherry DD. J. Rheumatol. 26:2036-2038 (1999).

Carboplatin and Cisplatin contain platinum

Carmustine and Cyclophosphamide cause DNA strand cross links

Apoptosis

Gemcitabine HydrochlorideGemcitabine Hydrochloride (G1745)

is a chemotherapeutic agent and an anti-metabolite that has demonstrated activity against various solid tumors such as non-small cell lung cancer (NSCLC), pancre-atic cancer, ovarian cancer, renal cancer, neck cancer, and breast cancer.1-5 It is often used in combination with other an-tineoplastic compounds, with one of the more popular combination treatments being a Gemcitabine/Carboplatin therapy commonly used to treat lung cancer.

Gemcitabine is a deoxycytidine-analog of cytarabine (1-beta-D-arabinofurano-sylcytosine, Ara-C) which is known to be the most effective chemotherapy drug used to treat adult acute leukemia.1 In

biological systems, the phosphory-lated derivative of gemcitabine retains its anti-tumor activities

in addition to having a longer half-life than that of Ara-C.2,4 As a result of its be-ing a nucleoside analog, Gemcitabine acts by inhibiting ribonucleoside diphosphate reductase activity. This inhibition pre-vents the cell from producing deoxyribo-nucleotides necessary for DNA replication and repair, eventually inducing apoptosis in the cell.2 In addition, the overall ac-tions that Gemcitabine metabolites exert on cellular regulatory processes serve to enhance the overall inhibitory activities on cell growth, a relatively rare interac-tion seen in other anticancer compounds known as “self-potentiation”.6 1. Matsui K, Fukuoka M. Gan To Kagaku Ryoho. 19: 2127-2132 (1992). 2. Hui YF, Reitz J. Am. J. Health Syst. Pharm. 54:162-170 (1997). 3. Lilenbaum RC, Green MR. J. Clin. Oncol. 11: 1391-1402 (1993). 4. Ruiz van Haperen VW, Peters GJ. Pharm. World Sci. 16: 104-112 (1994). 5. Christgen M, Schniewind B, Jueschke A, Ungefroren H, Kalthoff H. Cancer Lett. 227(2):193-200 (2005).6. Plunkett, W., et al. 1995. Semin. Oncol. 22: 3-10.

Acetoxychavicol Acetate1’ S-1’-Acetoxychavicol Acetate (ACA,

A0917) is the pungent component of galan-gal, Alpinia galanga. Galangal is a perennial plant belonging to the Zingiberaceae family. The rhizomes and seeds of galangal are used as a spice and herbal medicine. Galangal has various pharmacological functions such as: antioxidative, antigastric ulcer, antibacterial and antitumor effects.

Many pungent components like the hot pepper component, Capsaicin (C0266), and black pepper component Piperine (P3465) act on the transient receptor potential cation channel subfamily V, member 1 (TRPV1) to evoke pain and pungency. Pungent ACA also acts through the TRP receptor family, how-ever it is not known what kind of receptor is responsible for ACA pungency.1

NF-kB (nuclear factor kappa light chain enhancer of activated B cells) is a protein complex that controls the trascription of DNA. It is widely used by eukaryotic cells as a regulator of genes that control cell prolifiera-tion and cell survival. Constitutively active

NF-kB turns on the expression of genes that keep the cell proliferating and protect the cell from conditions that would otherwise cause it to die via apoptosis. In tumor cells NF-kB is active due to mutations in genes encoding the NF-kB transcription factors themselves; in addition some tumor cells secrete factors that cause NF-kB to become active. Blocking NF-kB can cause tumor cells to stop prolifer-ating, to die, or to become more sensitive to anti-tumor agents.2

ACA dramatically inhibits the cellular growth of human myeloma cells via the in-hibitior of NF-kB activity as well as inducing G0 – G1 phase cell cycle arrest, followed by apoptosis. Furthermore ACA significantly inhibits serine phosphorylation and degrada-tion of IkappaBalpha, an NF-kB like protein.3

D,L 1’-Acetoxychavicol Acetate (A0817) is a synthetic version of ACA.

1. Ito K, Nakazato T, Xian MJ. Cancer Res. 2005.2. Sheikh, MS, Huang Y. Cell Cycle 2(6): 550 -2. 2003.3. Escarcega RO, Fuentes-Alexandro S. Clinical Oncology 19(2): 154 – 61. 2007.

ACA is found in the root of Alpina galanga

Gemcitabine is an effective chemotherapy drug used to treat adult acute leukemia

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Apoptosis

PaclitaxelPaclitaxel (P0092), isolated from the

stem bark of the Pacific Yew tree (Taxus brevifolia Nutt.), was found to have sig-nificant antitumor activity against vari-ous leukemias, the Walker 256 carcino-sarcoma, Sarcoma 180, and Lewis lung tumor. Paclitaxel is of considerable in-terest because of its unique mechanism of action.1

In contrast to other antimitotic natu-ral products such as colchicine, podo-phyllotoxin and vinblastine that inhibit cell microtubule assembly,2 paclitaxel is the only antimitotic agent known so far to promote the assembly of stable mi-crotubules and inhibit the disassembly process of microtubules to tubulin by calcium ions and low temperature.3

Paclitaxel is active clinically against

advanced ovarian and breast cancer4, and is important in the treatment of several solid tumors.5 Paclitaxel shows promise in certain previously unre-sponsive tumors, such as lung, head and neck, esophageal, and bladder cancers.6 Furthermore, paclitaxel is currently un-der investigation in combination ther-apy, such as paclitaxel and doxorubicin for metastatic breast cancer.7 Paclitaxel in combination with a platinum analog is now considered first line therapy for advanced ovarian cancer.1

1. Suffness M, et al. Chemistry and Pharmacology. Vol. XXV, pp. 3-355 (1985). 2. Olmsted JB, Borisy GG. Biochem. 12, 4282 (1973).3. Manfredi JJ, Horwitz SB. Pharmacol. Ther. 25, 83 (1984). 4. Terwogt JM, Nuijen B, Huinink WW, Beijnen JH. Cancer Treat. Rev., 23:87-95 (1997). 5. Goldspiel BR. Pharmacotherapy, 17:110S-125S (1997). 6. Aisner J, Cortes-Funes H. Semin. Oncol., 24:S2-S113S2115 (1997). 7. Holmes FA. Semin. Oncol. 23:29-39 (1996).

AcivicinAcivicin (A0934) is a heterocyclic analogue

of L-glutamate, which was originally isolated from the fermentation products of Streptomyces sviceus. The large scale production of acivicin from fermentation is problematic due to several not easily separable contaminants.

Acivicin has potent anti-cancer activity and the potential to be used as a chemotherapeu-tic for a variety of carcinomas, melanomas and leukemia. Due to several side effects the com-pound does not have wide spread clinical use. The side effects associated with the compound include lethargy, hallucinations and mild am-nesia, which are from a metabolite of acivicin.

The mechanism of action of acivicin was discovered to be an irreversible inhibitor of cytosine triphosphate synthetase (CTP-synthe-tase) which is a key target for African sleeping sickness as well as formylglycinamide ribonu-cleotide synthetase, asparagines and glutamate synthase (GltS) and γ-Glutamyltranspeptidase (γ-GT).

Rapidly proliferating tumor cells have elevated activities of the glutamine

amidotransferases due to their in-

volvement in the de novo biosynthesis of purine and pyrimidine nucleotides. These elevated levels help supplement the rapidly dividing cells with essential amino acid precursors for gluta-thione and protein biosynthesis thus transfer-ring a growth advantage to the tumor cells.

In order for the γ-GT to transfer this ad-vantage it must first undergo a transformation from its inactive precursor to the active enzyme through an intramolecular autoprocessing event. Threonine 380 serves as the critical N-terminal nucleophile for facilitating the change.

Acivicin acts as an irreversible inhibi-tor through nucleophilic displacement of the chlorine atom by the attack of the threonine hydroxyl group. Collapse of the following tet-rahedral intermediate would then lead to dis-placement of the chloride ion.

Irreversible inhibition of the critical Thr 380 residue would lead to the γ-GT being unable to convert from its inactive precursor to the active molecule thus depriving the rapidly proliferat-ing cancer cell of essential glutathione and pro-tein components.1. Patricia Ruoso, 2001. University of Toronto Masters Thesis.2. Biochemistry, 2009, 48, 2459 – 2467.

Studies have shown Acivicin to inhibit growth of human pancreatic carcinoma cells

Paclitaxel is isolated from the Pacific Yew tree

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Isothiocyanates

SulforaphaneR-Sulforaphane (S8046) is a

cancer chemopreventive agent dis-covered by Dr. Paul Talalay and his team at the Johns Hopkins Univer-sity School of Medicine in 1992. Sulforaphane belongs to a general class of natural products that con-tain an isothiocyanate moiety. Iso-thiocyanates can be found in other cruciferous vegetables such as cauli-flower, cabbage, kale, and turnips.1-3

Sulforaphane, also known as 4-methylsulfinylbutyl isothio-cyanate and (-)-1-isothiocyanato-4-(R)-(methylsulfinyl) butane, has many interesting properties such as antimicrobial, antioxidant, and antitumor activities. It is reported that sulforaphane inhibits extracel-lular, intracellular, and antibiotic resistant strains of Helicobacter py-lori.4

Synthetic R,S-Sulforaphane (S8044), a racemic mixture, has been shown to be an effective agent in chemoprevention of chemi-cally induced mammary tumors in rats.5 Sulforaphane exerts its cancer chemopreventive property via the activation of detoxifying enzymes and induction of apoptosis. Phase I enzymes activate many carcinogens to highly reactive electrophilic me-tabolites capable of damaging DNA. Phase II enzymes convert these re-active electrophiles to less toxic and more easily excretable products.6

Sulforaphane is a very potent inducer of Phase II detoxication en-zymes such as glutathione S-trans-ferase (GST) and quinone reductase (QR).7-11 The induction of Phase II

enzymes is mediated by a mitogen-activated protein kinase pathway.11

In human prostate cell lines sul-foraphane was found to induce QR, GST and γ-glutamylcysteine syn-thetase accompanied by an increase of GSH synthesis.12 Sulforaphane is a strong Phase I enzyme inhibitor.13

It inhibits the phase I cytochrome P450 isoenzymes 2E1 and 1A2 which have been associated with the activation of carcinogens.14

Myzak MC and colleagues dis-covered sulforaphane also acts as an inhibitor of histone deacety-lase (HDAC) in HCT116 human colorectal cancer cells. They suggest sulforaphane may be effective as a tumor-suppressing agent and as a chemotherapeutic agent.15

The anticarcinogenic effect of sulforaphane has also been attrib-uted to its ability to induce multi-drug resistance associated protein 2 in primary rat and human hepto-cytes.16 In addition to the activation of detoxifying enzymes, induction of apoptosis is also involved in the sulforaphane-associated cancer chemoprevention.1. Misiewicz I, et al. Acta Biochimica Polonica. 51(3):711-721 (2004). 2. Verhoeven DT, Goldbohm RA, et al. Chem. Biol. Interact. 103:79-129 (1997). 3. Talalay P, Zhang Y. Biochem. Soc. Trans. 24:806-810 (1996). 4. Fahey JW, Haristoy X, et al. Proc. Natl. Acad. Sci. U. S. A. 99(11):7610-7615 (2002). 5. Zhang Y, Kensler TW, et al. Proc. Natl. Acad. Aci. 91:3147-3150 (1994). 6. Gamet-Payrastre L, Li P, et al. Cancer Res. 60:1426-1433 (2000). 7. Wattenberg LW, Shafer HW, et al. Proc Am. Assoc. Cancer Res. 30:181 (1989). 8. Lori R, Bernadi R, et al. Bioorg Med Chem Lett. 9:1047-1048 (1999). 9. Zhang Y, Talalay P, Cho C, Posner GH. Proc. Natl. Acad. Aci. USA 89:2399-2403 (1992). 10. Yu R, Lei W, et al. J. Biol. Chem. 274:27545-27552 (1999). 11. Maheo K, Morel F, et al. Cancer Res. 57:3649-3652 (1997). 12. Brooks JD, Paton VG, Vidanes G. Cancer Epidemiol. Biomark. Prev. 10:949-954 (2001). 13. Singletary K, MacDonald C. Cancer Lett. 155:47-54 (2000). 14. Fimognari C, Nusse M, et al. Biochem. Pharmacol. 68(6):1133-1138 (2004). 15. Myzak MC, Karplus PA, et al. Cancer Res. 64(16):5767-5774 (2004). 16. Payen L, Coutoies A, Loewert M, et al. Biochem. Biophys. Res. Commun. 282:257-263 (2001).

R-Sulforaphane is extracted from Broccoli

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Isothiocyanates

IsothiocyanatesThe consumption of cruciferous veg-

etables is the main dietary source of isothiocyanates.1 Benzyl and phenethyl isothiocyanates (BITC B1653, PEITC P2508) have been found to inhibit chem-ically-induced carcinogenesis in several animal models.2 BITC is particularly ef-fective against benzo[a]pyrene-induced lung tumorigenesis, while PEITC in-hibits NNK-induced lung carcinogen-esis.3

3-Phenylpropyl and 4-phenylbutyl isothiocyanates (PPITC P2515, PBITC P2510) are synthetic compounds that show anticarcinogenic effects.4 Studies on the effect of alkyl chain length of phe-nylalkyl isothiocyanates on tobacco spe-cific nitrosamine-induced lung tumori-genesis revealed that PPITC and PBITC

are more effective than the naturally oc-curing isothiocyanates.5

Isothiocyanates have been found to induce activity of the detoxifying en-zymes system, glutathione S-transfer-ase,6 and to suppress carcinogen activa-tion by cytochromes P450,2,7 particularly P450 2B1, the major enzyme involved in NNK activation.9

Also available: R-Sulforaphane (S8046), R,S- Sulforaphane (S8044), Phenylhexyl isothiocyanate (P2922)

1. Fenwick GR, Heaney RK, Mullin WJ. CRC Crit. Rev. Food Sci. Nutr. 18, 123-201 (1983). 2. Wattenberg LW. Carcinogenesis. 8, 1971-1973 (1987). 3. Lin JM, Amin S, Trushin N, Hecht SS. Cancer Lett. 74:151-159 (1993). 4. Zhang Y, Talalay P. Cancer Res. 54(7 Suppl):1976S-1981S (1994). 5. Morse MA, Eklind KI, Amin SG, Hecht SS, Chung F-L. Carcinogenesis. 10, 1757-1759 (1989). 6. Benson AM, Barretto PB. Cancer Res. 45, 4219-4223 (1985). 7. Morse MA, Amin SG, Hecht SS, Chung F-L. Cancer Res. 49, 2894-2897 (1989). 9. Conaway CC, Jiao D, Chung FL. Carcinogenesis, 17:2423-2427 (1996).

Cysteine ConjugatesS-(N-Benzylthiocarbamoyl)-

L-cysteine (B1655) and S-(N-3-phenylpropylthiocarbamoyl)-L-cysteine (P2816) are water-soluble phenylalkylisothiocyanate cysteine conjugates.1,2 Their parent compounds are Benzyl Isothiocyanate (B1653) and 3-Phenylpropyl Isothiocyanate (P2515), respectively, which have been reported to inhibit chemically induced carcinogenesis in laboratory animals.1-4

The induction of the detoxifying enzyme glutathione S-transferase (GST) by the two cysteine conjugates and their parent compounds has been determined and compared in several

tissues of A/J mice. The cysteine conjugates appear to be less

toxic and even more potent

as enzyme inducers than the parent compounds in some of the mouse tis-sues.5 Both conjugates were found to inhibit the growth of human leukemia 60 cells, and have anti-proliferative activity in vitro.6 It is believed that arylalkyl isothiocyanate cysteine con-jugates dissociate to the isothiocya-nate in order to be active.7

Also available: S-(N-Methylsulfinylbutylthiocarbamoyl)-glutathione (M1875), S-(N-Phenylbutylthiocarbamoyl)-glutathione (P2514), and S-(N-Phenylthioncarbamoyl)-glutathione (P2522)1. Chung FL, Jachatz A, Vitarius J, Hecht SS. Cancer Res. 44:2924-2928 (1984). 2. Chung FL, Wang M, Hecht SS. Carcinogenesis 6:539-543 (1985). 3. Morse MA, Wang CX, Stoner GD, et al. Cancer Res. 49:549-553 (1989). 4. Morse MA, Eklind KI, Hecht SS, et al. Cancer Res. 51:1846-1850 (1991). 5. Zheng GQ, Kenney PM, Lam LKT. J. Med. Chem. 35:185-188 (1992). 6 Adesida A, Edwards LG, Thornalley PJ. Food Chem. Toxicol. 34:385-392 (1996). 7. Conaway CC, Jiao D, Chung FL. Carcinogenesis, 17:2423-2427 (1996).

Cysteine Conjugates appear to be potent inducers of glutathione S-transferase

Isothiocyanates are commonly found in cruciferous vegetables

of Isothiocyanates

8

Ginsenosides

GinsenosidesGinseng has been used in East

Asia as a tonic for over 2000 years. Modern research has determined that this herb has pharmacological properties in the areas of cardio-vascular, endocrine and immune systems.1 The most widely used species of ginseng are the Panax ginseng, also known as Korean or Chinese ginseng, Panax quinquefo-lius, American ginseng, and Panax japonicus, Japanese ginseng.

The active ingredients in ginseng are ginsenosides, which belong to the chemical class of compounds known as steroidal saponins. Many of these ginsenosides have been isolated and identified. They can be separated into two groups: the panaxadiols and panaxatriols. In addition to the steroidal saponins other active ingredients such as gin-senoside Ro, an oleanic acid have also been identified.

Various ginsenosides have been found to have anticancer properties against tumor cell lines and tumor growth. Ginsenoside Rg3 inhibits growth in human prostate carci-noma LNCaP cells by activating cy-clin-kinase inhibitors arresting LN-CaP cell at G1 phase and inducing apoptosis.2 Ginsenoside Rh2 inhib-

its growth of MCF-7 human breast carcinoma cells by “inducing pro-tein expression of p21 and reducing the protein levels of cyclin D which resulted in the down-regluation of cyclin/Cdk complex kinase activity, decreasing phosphorylation of pRb, and inhibiting E2F release”.3 Gin-senoside Rh2 given by p.o. inhibits tumor growth in nude mice bearing human ovarian cancer cells.4

Ginsenosides Rb2 and Rg3 were found to inhibit B16-BL6 mela-noma and colon 26-M3.1 metasta-sis in syngeneic mice.5 The inhibi-tion appears to be associated with the antiangiogenic effects of these compounds.6 Ginsenosides Rb1 and Rg1 are the main ingredients responsible for the CNS effects of ginseng. Rb1 and Rg1 were shown to protect neurons from ischemic damage.7,8 Rb1, Rg1, as well as Re were found to prevent scopolamine-induced memory deficits.9-11

1. Attele AS, Wu JA, et al. Biochem. Pharm. 58:1685-93 (1999). 2. Liu WK, Xu SX, Che CT. Life Sci. 67:1297-306 (2000). 3. Oh M, Choi YH, Choi S, et al. Int. J. Oncol. 14:869-75 (1999). 4. Nakata H, Kikuchi Y, Tode T, et al. Jpn J. Cancer Res. 89:733-40 (1998). 5. Mochizuki M, Yoo YC, et al. Biol. Pharm. Bull. 18:1197-1202 (1995). 6. Sato K, Mochizuki M, Saiki I, et al. Biol. Pharm. Bull. 17:635-639 (1994). 7. Lim JH, Wen TC, Marsuda S, et al. Neurosci.. Res. 28:191-200 (1997). 8. Wen TC, Yoshimura H, Matsuda S, et al. Acta. Neuropathol. 91:15-22 (1996). 9. Benishin CG, Lee R, Wnag LCH, Liu HJ. Pharmacology 42:223-229 (1991). 10. Yamaguchi Y, Haruta K, et al. Psychoneuroendocrinol-ogy 20:645-653 (1995). 11. Yamaguchi Y, Higashi M, Kobayashi H. Biomed Res 17:487-490 (1996).

Ginsenosides are found in Ginseng

G3460 Ginsenoside F1G3461 Ginsenoside F2G3462 Ginsenoside F3G3454 Ginsenoside Rb1G3453 Ginsenoside Rb2G3554 Ginsenoside Rb3G3455 Ginsenoside Rc

G3456 Ginsenoside RdG3457 Ginsenoside ReG3458 Ginsenoside Rg1G3459 Ginsenoside Rg2G3556 Ginsenoside Rg3G3557 Ginsenoside Rh1G3453 Ginsenoside Rh2

G3552 20(S)-Ginsenoside Rg3G3558 20(R)-Ginsenoside Rh2

N5778 Notoginsenoside R1P0253 PanaxadiolP0254 PanaxatriolP6957 ProtopanaxadiolP6958 ProtopanaxatriolP7318 Pseudoginsenoside F11

LKT Products:

9

Cancer Chemoprevention

Caffeic Acid Esters

(Z)-4-Hydroxytamoxifen (4OHT H9711) is an active metabolite of (Z)-tamoxifen (TAM), which is a first generation selective estrogen receptor modulator (SERM) and TAM is ex-tensively used in estrogen-dependant breast cancer treatment.1 4OHT has higher binding affinity for estrogen re-ceptors than its precursor TAM and is 50-100 fold more potent for inhibiting normal human breast cell lines multi-plication.2

(E)-4-Hydroxytamoxifen (H9712) also has antiestrogen activity, however, it only has 5% of 4OHT affinity for es-trogen receptors.3

4OHT and TAM were found to be intramembranous inhibitors of lipid

peroxidation and scavengers of per-oxyl radicals.4 4OHT was reported to protect against oxidative stress in brain mitochondria.5 TAM and 4OHT induce depolarization of the mito-chondrial membrane potential and cause a decrease in mitochondrial ATP levels.6

Also available: Tamoxifen Citrate (T0250), (E, Z)-4-Hydroxytamoxifen

(H9716)

1. Jordan VC. J. Med. Chem. 46, 883 (2003). 2. Malet C, Gompel A, Spritzer P, et al. P. Cancer Res. 48, 7193-7199 (1988). 3. Murphy CS, Langan-Fahey SM, McCague R, Jordan VC. Mol. Pharmacol. 38, 737-743 (1990). 4. Custódio JBA, Dinis TCP, Almeida LM, Madeira VMC. Biochem. Pharmacol. 47, 1989-1998 (1994). 5. Moreira PI, Custódio JB, Oliveira CR, Santos MS. Biochem. Pharmacol. 68, 195-204 (2004). 6. Cardoso CMP, Moreno AJM, Almeida LM, Custódio JBA. Toxicol. In Vitro 17, 663-670 (2003).

Hydroxytamoxifen

Derivatives of Caffeic acid (C0121) constitute a class of naturally occurring plant phenolics with chemopreventive properties.1 Caffeates occur naturally in the conjugated form, but more frequently as esters than as glycosides.2

Possible mechanisms of action of caffeates include antioxidant or electro-phile trapping as modulators of arachidon-ic acid metabolism cascade pathways, cell protein kinase inhibition, and inhibition of carcinogenesis.3 Esters of caffeic acid, such as methyl caffeate (M1560), phenethyl caffeate (P2400), and phenethyl dimethyl caffeate (P2410) all inhibit the mutagen-icity of 3,2”- dimethyl-4-aminobiphenyl (DMAB) in the Ames test, and are cy-totoxic toward colon adenocarcinoma cells.4

Phenethyl caffeate also shows differ-ential cytotoxicity in transformed

rat/human melanoma and breast carcinoma cell lines.5 Dietary

phenylethyl-3-methyl caffeate significantly inhibits both the incidence and multiplic-ity of invasive, noninvasive, and total ad-enocarcinomas of the colon.6 Ferulic acid (F1669) is the 3-methyl ether of caffeic acid.

Curcumin (C8069) is structurally re-lated to caffeic acid, and is the coloring material from the root of Curcuma spe-cies. Curcumin inhibits lipoxygenase and cyclooxygenase, and is an antipromoter with antioxidant and anti-inflammatory properties.7

Also available: n-Octyl Caffeate (O1176), and conjugates (O1177-O1179)1. IARC Working Group, IARC Monogr. Eval. Carcinog. Risks Hum., Vol. 56, pp. 115-134 (1993). 2. Herrman K. CRC Crit. Rev. Food Sci. Nutri., 28:315-347 (1989). 3. Newmark HL. Dietary Phytochem. in Cancer Prevention and Treatment , AICR, N.Y., pp. 25-34 (1996). 4. Rao CV, Desai D, Kaul B, Amin S, Reddy BS. Chem.-Biol. Int., 84:277-903 (1992). 5. Gurnberger D, Banerjee R, Eisinger K, et al. Experientia, 44:230-232 (1988). 6. Rao CV, Desai D, Rivenson A, Simi B, Amin S, Reddy BS. Cancer Res., 55:2310-2315 (1995) 7. Huang MT, Lysz T, Ferraro T, Abidi TF, Laskin JD, Conney AH. Cancer Res., 51:813-819 (1991).

(Z)-4-Hydroxytamoxifen is reported to protect against oxidative stress in brain mitochondria

Caffeic acid is found in Valerian root

10


IndolesSeveral indole-based compounds are

found in cruciferous vegetables such as cab-bage, broccoli, and brussel sprouts.1,2 They are derived from a common parent com-pound, glucobrassicin. Consumption of these vegetables has been shown to prevent certain types of cancer. Researchers have demonstrated that indoles possess chemo-preventive properties.3,4

Indole-3-carbinol (I3C I5213) inhibits carcinogenesis at the initiation stage.5 It has been shown to inhibit chemically-induced carcinogenesis in several animal models.5,6 However, enhanced liver carci-nogenesis in trout and lung carcinogenesis in mice indicate that I3C may also act as a promoter.7 The induction of phase I as well

as phase II drug metabolizing enzymes may explain the simultaneous oc-

currence of both chemopreventive and co-carcinogenic properties in

I3C.5 3,3”-Diindolylmethane (D3232), a di-

mer of I3C, induces apoptosis in human cancer cells.8 It inhibits several cytochrome P450 isozymes in vitro and may be the active metabolite of I3C responsible for its chemo-preventive properties.9

Brassinin (B6801), isolated from Chi-nese cabbage,10 has been found to inhibit dimethylbenz[a]anthracene-induced pre-neoplastic lesions in mouse mammary gland cultures.10

1. Goetz JK, Schravdolf HR. Phytochemistry 22:905-908 (1983). 2. Takasugi M, Katsui M, et al. J. Chem. Soc. Chem. Commun. 1077-1078 (1986). 3. Wattenberg LW, Loub WD. Cancer Res., 38:1410-1413 (1978). 4. Chung FL, Morse MA, Eklind KI. Cancer Res. 52:2719s-2722s (1992). 5. Grubbs CJ, Steele VE, Casebolt T, et al. Anticancer Res. 15:709-716 (1995). 6. Arnao MB, Sanchez-Bravo J, et al. Biochem. Mol. Biol. Int. 39:1125-1134 (1996). 7. Bailey GS, Dashwood RH, et al. IARC Sci. Publ. 105:275-280 (1991). 8. Ge X, Tannai S, et al. Biochem. Biophys. Res. Commun. 228:153-158 (1996). 9. Stresser DM, Bjeldanes LF, et al. J. Biochem. Toxicol. 10:191-201 (1995). 10. Mehta RG, Liu J, Constantinou A, et al. Carcinogenesis 16:399-404 (1995).

Organosulfur CompoundsThe topical application of onion and

garlic oils to carcinogen treated mice in-hibits skin tumor formation.1 The active chemopreventive ingredients in onion and garlic are organosulfur compounds, which are released when their bulbs are cut and exposed to oxygen. The rela-tionship of organosufur compounds to cancer prevention has been the subject of several reviews.2-4 Organosulfur com-pounds are effective in preventing colon, esophagus, forestomach, lung and mam-mary tumors.2

Diallyl sulfide (D3201) is a particu-larly strong inhibitor of dimethylhydra-zine induced tumors in the colon and N- nitrosodimethylbenzylamine in-duced tumors in the esophagus of rats.2 Allyl disulfide (A4544) is a potent inhibitor of forestomach tumors in-duced by N-nitrosodiethylamine and azoxymethane induced colon tumors

in the rat.5,6 Diallyl trisulfide (D3202) prevents benzo[a]pyrene (B1652) in-duced lung tumors.2 Dipropyl sulfide (D3262) was found to inhibit NNK acti-vation during lung carcinogenesis.7 The potency of organosulfur compounds as inhibitors of tumorigenesis depends on their ability to induce glutathione-S-transferase (GST),8 particularly GSTp isozyme-dependent activity.9 Diallyl sulfide and allyl disulfide also suppress cytochrome P450 2E1, but elevate P450s 2B1/2 and 1A2 in the rat.10

1. Belman E. Carcinogenesis, 4:1063-1065 (1983). 2. Wargovich MJ, Uda N, Woods C, et al. Biochem. Soc. Trans. 24:811-814 (1996). 3. Lea MA. Adv. Exp. Med. Biol. 401:147-154 (1996). 4. Wargovich MJ, Uda N. Adv. Exp. Med. Biol. 401:171-177 (1996). 5. Wattenberg LW, Sparnins VL, Barany G. Cancer Res. 49:2689-2692 (1989). 6. Reddy BS, Rao CV, et al. Cancer Res. 53:3493-3498 (1993). 7. Wattenberg LW. Proc. Nutr. Soc.,49:173-183 (1990). 8. Srivastava SK, Hu X, Xia H, et al. Cancer Lett. 118:61-67 (1997). 9. Hu X, Benson PJ, et al. Arch. Biochem. Biophys. 336:199-214 (1996). 10. Haber D, Siess MH, et al. J. Toxicol. Environ. Health 44:423-434 (1995).

Indoles are found in many cruciferous vegetables, including cabbage

Organosulfur compounds are found in onions and garlic

11


Selenium CompoundsSelenium is required to maintain proper

immune system functions and to prevent cel-lular oxidative damage, it may also play an im-portant role in cancer prevention.1

Organoselenium compounds, such as sele-nomethionine (S1845), have been the subject of much research. Selenomethionine is recog-nized as a safe and effective form of selenium supplementation.2,3 Selenoamino acids can be incorporated into proteins, which diminishes their effectiveness in cancer prevention.2 Se-methylselenocysteine (S1848) is incorporat-ed non-specifically into proteins.2 This makes it about 500-750 times more effective than S-methylcysteine (S1565) at preventing chemi-cally induced mammary tumors in rats.4 The synthetic compound, benzyl selenocyanate (BSC B1654), is an effective inhibitor of chemically-induced mouse forestomach car-cinogenesis,5 and is less toxic than inorganic selenium.6

Another synthetic organoselenium com-

pound, p-xyleneselenocyanate (p-XSC X1854), was introduced in 1992.7 p-XSC is even less toxic than BSC.8 p-XSC is reported to have the most potent inhibitory effect of any selenium compound on chemically in-duced mammary, lung, and colon carcinogen-esis in animal models.9 p-XSC has undergone clinical trials as a chemopreventive10 and is a good candidate for further investigation of chemoprevention of other types of cancer.1. Axley MJ, Bock A, Stadtman TC. Proc. Natl. Acad. Sci. U.S.A. 88:8450-8454 (1991). 2. Ip C, Ganther HE. in Cancer Chemoprevention, Wattenberg L, Lipkin M, Boone CW, Kelloff GJ, eds, CRC Press, pp. 479-488 (1992). 3. Badmaev V, Majeed M, Passwater RA. Altern. Ther. Health Med. 28:59-63 (1996). 4. Ip C, Ganther HE. Carcinogenesis 13:1167-1170 (1992). 5. El-Bayoumy K. Cancer Res. 45:3631-3635 (1985). 6. Blackwell L, Mathis J, Asaad WW, et al. Drug Metab. Disp. 19:865-870 (1991). 7. Conaway CC, Upadhyaya P, Date V, et al. Fundam. Appl. Toxicol. 19:563-574 (1992). 8. Sohni OS, Li H, Surace A, et al. Anticancer Res. 15:1849-1856 (1995). 9. El-Bayoumy K, Upadhyaya P, Chae YH, et al. J. Cell. Biochem. 22:92-100 (1995). 10. Kelloff GJ, Crowell JA, Hawk ET, et. al. J. Cell Biochem. Suppl. 26:54-71 (1996).

Coffee CompoundsCoffee consumption has been associ-

ated with a reduction in colon cancer.1 Cafestol (C0020) and Kahweol (K0030) are diterpenes isolated from coffee beans.2 In animal studies, diets supplemented with cafestol and kahweol resulted in a reduc-tion of DNA-carcinogen adduct forma-tion,3 and the reduction of the frequency of adenocarcinoma4 of the colon in rats.

Green coffee beans have been found to inhibit chemically induced mammary tu-mors in Sprague Dawley rats.5 This obser-vation led researchers to identify Cafestol and Kahweol palmitates (C0022, K0032) as the active components in green coffee beans.6 These two compounds were found to be responsible for the induction of the detoxifying enzyme system, glutathione S-transferase(GST),7 particularly GST mμ isozyme-dependent activity in mice,8 and

placental GST activity in rats.9 An increase of GST activity is cor-related with anti-carcinogenic

activity of some chemopreventive agents. Partial or total saturation of the furan ring of cafestol by catalytic hydrogenation resulted in total elimination of the GST inducing activity. These observations sug-gest that the furan moiety is the critical functional group that defines the activity of furan-containing diterpenes as inducers of GST.10

Also available: Cafestol acetate (C0021), eico-sanate (C0025), linoleate (C0027), oleate (C0029), stearate (C0033), Kahweol acetate (K0031), eico-sanate (K0034), linoleate (K0036), oleate (K0038), stearate (K0040)1. Baron JA, deVerdier MG, Ekbom A. Cancer Epidemiol. Biomarkers Prev. 3:365-570 (1994). 2. Slotta KH, Neisser K. Ber. 71:1991-1994 (1938). 3. Huber WW, McDaniel LP, Kaderlik KR, et al. Mut. Res. 376:115-122 (1997). 4. Gershbein LL. Anticancer Res. 14:1113-1116 (1994). 5. Sparnins VL, Lam LKT, Wattenberg LW. Proc. Am. Assoc. Cancer Res. 22:114 (1981). 6. Wattenberg LW, Lam LKT in Banbury Report 17:Coffee and Health, pp. 137-144 (1984). 7. Lam LKT, Sparnins VL, Wattenberg LW. Cancer Res. 42:1193-1198 (1982). 8. DiSimplicio P, Jensson H, Mannervik B. Biochem. J. 263:679-685 (1989). 9. Schilter B, Perrin I, Cavin C, Huggett AC. Carcinogenesis. 17:2377-2384 (1996). 10. Lam LKT, Sparnins VL, Wattenberg LW. J. Med. Chem. 30:1399-1403 (1987).

There is no cafestol or kahweol found in conventional brewed coffee

Brazil nuts are one of the most concentrated food sources of selenium

12

Antioxidants

LycopeneLycopene (L9609) is one of the carot-

enoids that is present in fruits and veg-etables. Tomatoes are the primary dietary source of lycopene.1 Lycopene acts as an antioxidant and protects cells against pho-tooxidative damage.2 It has been found to inhibit chemically-induced rat urinary bladder tumor formation.3 In humans, the consumption of tomato based foods has been associated with a reduced risk of prostate cancer, and evidence suggests that this is due to the presence of lycopene in these foods.4

Lycopene is under investigation as a chemopreventive agent. Dietary lycopene decreases chemically-induced liver preneoplastic foci in the rat.5 A diet

supplemented with lycopene was found to significantly suppress

spontaneous mammary tumor

development in SHN virgin mice.6 Serum lycopene concentrations have

been associated with a decreased risk of breast cancer in women.7 The chemopre-ventive properties of lycopene may be at-tributed to its antioxidant nature.8 Alternatively, a correlation has been found between the ability of carotenoids such as lycopene to enhance gap junction commu-nication and their abilities to inhibit chem-ically-induced neoplastic transformations in C3H/10T1/2 cells.9

1. Gartner C, Stahl W, Sies H. Am. J. Clin. Nutr. 66:116-122 (1997). 2. Rousseau EJ, Davison AJ, Dunn B. Free Radic. Biol. Med. 13:407-433 (1992). 3. Okajima E, Tsutsumi M, Ozono S. Jpn. J. Cancer Res. 89:22-26 (1998). 4. Clinton SK, Emenhiser C, et al. J. Cancer Epidemiol. Biomarkers Prev. 5:823-833 (1996). 5. Astorg P, Gradelet S, Berges R, Suschetet M. Nutr. Cancer 29:60-68 (1997). 6. Nagasawa H, Mitamura T, et al. Anticancer Res. 15:1173-1178 (1995). 7. Dorgan JF, Sowell A, Swanson CA, et al. J. Cancer Causes Control 9:89-97 (1998). 8. Buitti E, Munoz N, Kato I, et al. Int. J. Cancer 65:317-322 (1996). 9. Zhang LX, Cooney RV, Bertram JS. Carcinogenesis, 12:2109-2114 (1991).

ResveratrolResveratrol (R1776) is a stilbene-type

phytoalexin found in the skin and seeds of grapes, peanuts, mulberries and sev-eral medicinal plants.2 Phytoalexins are organic metabolites produced by plants in response to fungal infections, heavy met-als, or UV-radiation.1

A major dietary source of resveratrol is red wine.2 The health benefits of red wine consumption have been attributed to the polyphenol fraction, which contains resve-ratrol. Resveratrol is a strong antioxidant.3,4 It has been shown to inhibit low-density lipoprotein oxidation,5,6 and to ameliorate oxidative stress induced in cultured PC12 cells.7 Other biological effects of resvera-trol include lowering fat content in the rat liver,8 reducing cholesterol levels,9 and in-hibiting platelet aggregation.8

Resveratrol displays a wide range of chemopreventive properties.10 It blocks the initiation of carcinogenesis by acting as an antimutagen and a phase II drug-

metabolizing enzyme inducer. It mediates anti-inflammatory effects and inhibits cy-clooxygenase and hydroperoxidase func-tions, which have been implicated in can-cer promotion. Furthermore, resveratrol induces cancer cell differentiation, inhibits pre-neoplastic lesions in cultured carcino-gen-treated mouse mammary glands, and inhibits tumorigenesis in mouse skin. In addition, reveratrol inhibits the growth of estrogen receptor negative MDA-MB-231 breast cancer cells by inducing apoptosis.11

1. Langcake P, Pryce RJ. Experientia 33:151-152 (1977). 2. Soleas GJ, Diamandis EP, Goldberg DM. J. Clin. Lab. Anal. 11:287-313 (1997). 3. Miller NJ, Rice-Evans CA. Clin Chem. 41:1789 (1995). 4. Goldberg DM. Clin. Chem. 42:113-114 (1996). 5. Frankel EN, Waterhouse AL, Kinsella JE. Lancet 341:1103-1104 (1993). 6. Belguendouz L, Fremont L, Linard A. Biochem. Pharmacol. 53:1347-1355 (1997). 7. Chanvitayapongs S, Draczynska-Lusiak B, Sun AY. Neuroport. 8:1499-1502 (1997). 8. Soleas GJ, Diamandis EP, Goldberg DM. Clin. Biochem. 30:91-113 (1997). 9. Goldberg DM, Hahn SE, Parkes JG. Clin. Chim. Acta. 237:155-187 (1995). 10. Jang M, Cai L, Udeani GO, et al. Science. 275:218-220 (1997). 11. Alkhalaf M. Eur J Cancer Prev. 16: 334-41 (2007).

Tomatoes are the most common source of Lycopene

Resveratrol is found in red wine

13

Flavonoids

FlavonoidsFlavonoids occur naturally as glyco-

sides, and consist of flavones, flavonols, isoflavones and flavonones.2 It is estimated that humans whose diet is high in fruits and vegetables ingest up to 1 gram of fla-vonoids daily. Flavonoids are the most im-portant phenolics in food and are potent chemopreventive agents that act by several mechanisms including the arachidonic acid metabolism cascade, or inhibiting chemical mutagens.1 They are largely re-sponsible for the antioxidant properties of wines, teas and fruit juices.2

Chrysin (C2968) is a flavone that in-hibits metabolic activation of benzo[a]py-rene.3 Chalcone (C2800) is an open-chain flavone that inhibits lung and forestomach carcinogenesis.4 Quercetin (Q8016), in-hibits lipoxygenase and ornithine decar-boxylase induction.5 Genistein (G1652)

and Daidzein (D0032) are isoflavones found in soy which are antioxidants and weak estrogens.6 Another isoflavone, Bio-chanin A (B3358), inhibits cell prolifera-tion and differentiation as well as possess-es chemopreventive properties.7

The flavonone, Epigallocatechin Gal-late (G6234) is an active component of tea for chemoprevention.8 Silymarin (S3345) is a mixture of flavonones from milk thistle that have shown chemopreventive activity.9

1. Newmark HL. Dietary Phytochemicals in Cancer Prevention and Treat-ment pp. 25-34 (1996). 2. Rice-Evans CA, Miller NJ. Biochem. Soc. Trans., 24:790-795 (1996). 3. Chae YH, Ho DK, Cassady JM, et. al. Chem. Biol. Int. 82:181-193 (1992). 4. Wattenberg LW, Coccia JB, Galbraith AR. Cancer Lett. 83:165-9 (1994). 5. Nakadate T, Aizu E, Yamamoto S, Kato R. Prostaglandins 30:357-368 (1985). 6. Wiseman H. Biochem. Soc. Trans. 24:795-800 (1996). 7. Chae YH, Ho DK, Cassady JM, et al. Chem. Biol. Int. 82:181-193 (1992). 8. Dong Z, Ma W, Huang C, Yang CS. Cancer Res. 57:4414-4419 (1997). 9. Zi X, et al. Clin. Cancer Res. 4:1055-64, 1998. 239(1): 334-339 (1997).

FormononetinIsoflavones derived from many

edible plants have been reported to possess significant antioxidant, estrogenic and tyrosine kinase in-hibitory activity. Formononetin (F5770) is a natural isoflavone found in red clover (trifolium pratense). Formononetin was test-ed for its neuroprotective efficacy against two toxic insults, glutamate and beta-amyloid. Results show it exerts a neuroprotective effect at the plasma membrane.1 Morito K. et al. find formononetin binds well to hu-man estrogen receptor beta and al-pha proteins.2

Interaction of hemoglobin and Xanthine oxidase generates

hydroxyl radicals. For-

mononetin prevents the generated radicals from oxidizing lecithin.3 It is reported that formononetin in-hibits proliferation, collagen and total protein synthesis, migration and MAP kinase activity in human aortic smooth muscle cells.4

Literatures demonstrate for-mononetin also possesses anti-(H. pylori) activity. It may be a useful chemopreventive agent for pep-tic ulcer or gastric cancer in (H. pylori)-infected individuals.5

1. Zhao L, Chen Q, Diaz Brinton R. Exper. Bio. Med. 227:509-519 (2002). 2. Morito K, Aomori T, Hirose T, et al. Biol. Pharm. Bull. 25:48-52 (2002). 3. Toda S, Shirataki Y. Phytother. Res. 13:163-165 (1999). 4. Dubey RK, Gillespie DG, Imthurn B. et al. Hypertension 33:177-182 (1999). 5. Fukai T, Marumo A, Kaitou K, et al. Life Sciences 71:1449-1463 (2002).

Formononetin is found in Trifolium pratense

Flavonoids are found in high concentrations in fruits and vegetables

14

Flavonoids

IcariinIcariin (I0901) is a flavonol glyco-

side isolated from plants in the Epime-dium family. Lee et al. discovered that icariin significantly reduced the level of glutamic pyruvic transaminase and sorbitol dehydrogenase released resulting in a 76% protection from toxicity at concentrations of 1 μM to 20 μM.1 Zhao, et al. concluded that icariin had the effects of induction of differentiation on HL-60 cells and the mechanism might be related to elevat-ing the cAMP/cGMP ratio.2

He et. al. reported that icariin in certain concentrations could increase

lymphokine-activated killer cell (LAK) activity in both tumor

patients and healthy donors

and natural killer cell activity in tumor patients. Icariin stimulates produc-tion of tumor necrosis factor-alpha in monocytes from healthy donors. They claimed that generation of LAK cells in the presence of an appropriate dose of icariin might be superior to inter-leukin-2 alone.3

Icariin, along with related Epimedi-um-derived phytoestrogen flavanoids, exert a beneficial effect on prevent-ing bone loss in late postmenopausal women.4

1. Lee MK, Choi YJ, Sung SH, et al. Planta Medica. 61(6):523-526 (1995). 2. Zhao Y, Cui Z, Zhang L. Chin. J. of Oncol. 19(1):53-55 (1997). 3. He W, Sun H, Yang B, Zhang D, Kabelitz D. Arzneimittel-Forschung. 45:910-913 (1995).4. Zhang G, QinL, Shi Y. J. Bone Miner. Res. 22:1072-1079 (2007).

WogoninWogonin (W5726) is a natural

flavanoid derived from the root of Scutellaria baicalensis Georgi. This medicinal plant is traditionally used in Chinese medicine.1 Wogonin is reported to have a wide spectrum of biological activities including anti-inflammatory, neuroprotective, anti-oxidant and anti-cancer effects.1,2,3

Wogonin demonstrates potent apoptotic effects on human promyelo-leukemic cells HL-60. Wogonin also induces dose- dependent apoptosis on hepatocellular carcinoma cells in ad-dition to DNA fragmentation.

The apoptosis mechanism for hepa-tocellular carcinoma cells was through caspase-3 activation and induction of p53 protein.2 Although the antican-cer agent Etoposide (E7657) induces

apoptosis in normal and cancer cells, it also causes adverse effects such as myelosuppression. Wogonin was found to prevent thymocyte apoptosis caused by etoposide.

Addition of wogonin to etoposide-treated Junkart, HL-60 and lung can-cer cells caused acceleration in cell death. These results suggest that con-comitant treatment of wogonin and etoposide may be very useful in che-motherapy with reduced adverse side effects.4

Baicalin (B0133), the glycoside of Wogonin is also found in Scutellaria baicalensis Georgi.1. Heasuk L, Young O, Hocheol K, Hocheol K, and Sun K, et. al. FASEB Journal. 17: 1943-1944 (2003). 2. Chen YC, Shen SC, Lee WR, Lin HY, Ko CH, Shih CM, Yang LL. Arch. Toxicol. 76: 351-359 (2002). 3. Chang Y, Shen J, WungB, Cheng J, and Wang D. Mol. Pharm. 60: 507-513 (2001). 4. Lee E, Enomoto R, Suzuki C, Ohno M, Ohashi T, and Miyauchi A. et.al. Ann N Y Acad Sci. 1095: 521-526 (2007).

Icariin is found in the Epimedium family of plants

Wogonin is found in Scutellaria baicalensis Georgi

15

Antimicrobials

FluoroquinolonesThe fluoroquinolones are one of

the few synthetic antibiotics that are widely used as antibacterial. Fluo-roquinolones inhibit DNA synthesis by segmentation of bacterial DNA in the DNA-enzyme complexes of DNA gyrase and type IV topoisomerase, causing bacterial death.1,2 The former targets Gram (-) bacteria and the latter targets Gram (+) bacteria.

The flouroquinolones can be clas-sified into four generations accord-ing to antimicrobial activity.3 First generation fluoroquinolones are used less often today. Second generation in-cluding Norfloxacin (N5768), Ofloxa-cin (2144), Ciprofloxacin (C3262) improves activity against Gram (-)

bacteria and atypical pathogen cov-erage. Sparfloxacin (S6000), Gati-floxacin (G0278), and Moxifloxacin HCl (M5794), which belong to third generation, illustrate in vitro anaerobic activity. Clinafloxacin HCl (C4535) a new fourth generation of fluoroquino-lones affects both gram-negative and gram-positive bacteria, aerobes and anaerobes.

Also available: Ciprofloxacin HCl (C3263), Difloxacin HCl (D3223), Enrofloxacin (E5369), Levofloxacin HCl (L1786), Nadifloxacin (N0114), Pazufloxacin Mesylate (P0398)1. Levine C, Hiasa H, et al. Biochim. Biophys. Acta. 1400:29-43 (1998). 2. Oliphant CM, Green GM. American Family Physician. 65:455 (2002).3. Owens RC Jr., Ambrose PG. Med. Clin. North. Am. 84: 1447 (2000).

ConazolesConazoles have been used as fungi-

cides in agriculture and as human or veterinarian antifungal agents. They have a broad range of antifungal ac-tivity with the ability to stop or pre-vent fungal infections. Conazoles act by inhibiting the enzyme cytochrome P450 14a-demethylase, effectively stopping conversion of lanosterol to ergosterol, which is an essential com-ponent of the fungal cell membrane.1

Conazoles are usually divided into two groups. The first group consists of compounds that possess the triazole functional group, which are also col-lectively referred to as triazole fungi-cides.3,4 The second group bears the

imidazole functionality.2 Triazoles are more attractive as they are

less toxic than imidazoles.5

Triazole Functional:Fluconazole (F4682)Itraconazole (I7870) Cyproconazole (C9863) Difenoconazole (D3320) Epoxiconazole (E6259)Tebuconazole (T1604) Triticonazole (T7135) Uniconazole (U5232)

Imidazole Functional:Ketoconazole (K1676)Triflumizole (T6932)Miconazole (M3309) Tioconazole (T3357)

1. Venkatakrishan K, von Moltke LL, Greenblatt D. J. Clin. Pharmacokinet. 38:111-180 (2000). 2. Maertens JA. Clin. Microbiol. Infect. 10 Suppl 1:1-10 (2004). 3. Shao PL, Huang LM, Hsueh PR. Int. J. Antimicrob. Agents 30:487-495 (2007). 4. Nagappan V, Deresinski S. Clin. Infect. Dis. 45:1610-1617 (2007) 5. Terrell CL. Mayo Clin. Proc. 74:78-100 (1999).

Sporocarp fungus under 800x magnification

Enterobacter cloacae under 1000x magnification

16

NSAIDs

Flufenamic acidFlufenamic acid (F4483) belongs to

the class of N-phenylanthranilic acids and is widely used as nonsteroidal anti-inflammatory drugs by its ability to in-hibit cyclooxygenases. Cyclooxygenase (COX) is a key enzyme in the biosynthe-sis of prostaglandins and is the target of non-steroidal anti-inflammatory drugs (NSAIDs). Two isoforms exist, being expressed constitutively (COX-1), or inducibly in response to inflammatory mediators (COX-2). Selective COX-2 isoform inhibition may eliminate un-wanted side effects. Flufenamic acid is a time independent inhibitor towards both isoforms and is non-selective.1

Jordani MC et al. investigated the effects of flufenamic acid on mitochondrial respiration,

electrical transmembrane potential difference, osmotic swelling, Ca2+ ef-flux, NAD(P)H oxidation and reactive oxygen species (ROS) generation. They found that flufenamic acid caused mito-chondrial uncoupling by a protonophor-ic mechanism. NAD(P)H oxidation and ROS generation (H2O2 production) by mitochondria were markedly stimulated by flufenamic acid.2

Flufenamic acid also represents a novel class of reversible gap junction blockers that can be used to study the role of Cx43-mediated gap junctional in-tercellular communication in biological processes.3

1. Ouellet M, Percival MD. Biochem. J. 306 (Pt 1):247-251 (1995). 2. Jordani MC, Santos AC, et al. Mol. Cell. Biochem. 210(1-2):153-158 (2000). 3. Harks EG, et al. J. Pharmacol. Exp. Ther. 298(3):1033-1041 (2001).

Cyclooxygenase-2 InhibitorsCOX-2 inhibitors belong to a class of

nonsteroidal anti-inflammatory drugs (NSAID) that directly target cyclooxy-genase-2 (COX-2), which is an enzyme that is responsible for inflammation and pain.1,2 Unlike regular NSAIDs, COX-2 inhibitors do not inhibit cy-clooxygenase-1 (COX-1), an enzyme present in different areas of the body, including the stomach. COX-1 pro-duces prostaglandins that make natu-ral mucus that protects the stomach.

By blocking the activity of COX-1, NSAIDs cause stomach irritation, ul-ceration and bleeding. The specificity of COX-2 inhibitors makes them supe-rior anti-inflammatory drugs.

COX-2 inhibitors have been also studied as cancer chemoprevention drugs due to their ability to prevent

inflammation.3,4,5 Recently COX-2 inhibitors were investigated as che-mopreventive agents for colorectal cancer,6 prostate cancer,3 and breast cancer.7

Representative COX-2 inhibitors include:

Rofecoxib (R5722)Valdecoxib (V0245)Celecoxib (C1644)Lumiracoxib (L8248)Niflumic Acid (N3322)Etodolac (E7556)Carprofen (C0351)Nimesulide (N3450)

1. Reuben SS. Curr. Opin. Anaesthesiol. 20:440-450 (2007). 2. Harris RC, Breyer MD. Clin. J. Am. Soc. Nephrol. 1:236-245 (2006). 3. Gallego AG, Prado DS, Fonseca JP, et al. Clin. Transl. Oncol. 9:694-702 (2007). 4. Surh YJ, Kundu JK. Curr Cancer Drug Targets 7:447-458 (2007). 5. Sarkar FH, Adsule S, Li Y, Padhye S. Mini. Rev. Med. Chem. 7:599-608 (2007). 6. Das D, Arber N, Jankowski JA. Digestion 76:51-67 (2007). 7. Howe LR. Breast Cancer Res. 9:210 (2007).

COX-2 inhibitors are unique form of NSAIDs by not targeting COX-1

Flufenamic acid has a wide variety of uses

17

NSAIDs

GlitazonesThiazolidinediones are a new class

of drugs used for the treatment of type 2 diabetes and act by improving insulin sensitivity in adipose tissue, liver, and sketetal muscle.1 Both Rosi-glitazone (R5773) and Pioglitazone HCl (P6954) are used in monotherapy and in combination with sulfonylureas and Metformin HCl (M2075) in type 2 adult diabetes patients. Ciglitazone (C3210), an PPAR-gamma agonist, is an antidiabetic thiazolidinedione.2 Research shows ciglitazone can induce apoptosis and inhibit COX-2.3,4

1. O’Moore-Sullivan TM, Prins JB. Med. J. Aust. 176(8):381-386 (2002). 2. Chang AY, Wyse BM, Gilchrist BJ, et al. Diabetes 32:830-838 (1983). 3. Han S, Roman. J. Biochem Biophys Res Commun. 314:1093-1099 (2004). 4. Ignatenko NA, Babbar N, Mehta D, et al. Mol Carcinog. 39:91-102 (2004).

Apoptosis InhibitorsNeurodegenerative diseases such as

Parkinson’s and Alzheimer’s are character-ized by progressive cell death of neurons. Apoptosis is considered to be a common cause of cell death in neurodegenerative diseases and may be induced by various genetic and environmental factors. The apoptotic cascade is activated by tightly controlled, step-wise processes and has been proposed as a target for neuroprotec-tive strategies.

One way the step-wise apoptotic process is mediated is through caspases. Caspases are a group of cysteine proteases which play a central role in protein degradation in the apoptotic cascade. Inhibitors of the cas-pase family work in a variety of brain inju-ry models. In a model of neonatal hypoxia ischemia, caspase inhibitor administration was significantly neuroprotective when given up to 3 hours after the insult.

Citalopram HCl (C3477): is a selective serotonin reuptake inhibitor and antide-

pressant which reduces the erratic mo-tor behaviors associated with Alzheimer’s disease. It has also been shown to prevent staurosporine induced apoptosis.1

Aniracetam (A5326): attenuates apop-tosis of astrocytes subjected to simulated ischemia in vitro.2

Bongkrekic Acid (B5753): ameliorates ischemic cell death in the cortex by pre-venting cyt. C release and inhibiting astro-cyte activation.3

Flupirtine Maleate (F4583): blocks apoptosis in batten patient lymphoblasts and in human post mitotic CLN3 and CLN2 deficient neurons.4

(-)-Huperize A (H8162): Attenuates apoptosis and mitochondria dependent caspase-3 cortical neurons.5

1. Andersen, G, Vestergaard K. Lancet 1993 8875: 837 – 839.2. Gabryel B, Adamczyk J. Neurotoxicity 2002 23(3): 385 – 395.3. Muranyi M, Li PA Neurosci Lett. 384(3): 277-281.4. Dhar S, Bitting RL Ann. Neurol. 2002 51(4): 448-466.5. Zhou J, Tang XC FEBS Letters 526(1):21 – 25.

Sulindac (S8145) is a non-steroidal an-ti-inflammatory drug (NSAID) commonly used to treat rheumatoid arthritis, osteo-arthritis and ankylosing spondylitis.1 Su-lindac has been found to inhibit carcino-genesis in the colon and other tissues.2 The metabolic conversion of sulindac gives two products, the sulfide as a result of revers-ible reduction and the sulfone as a conse-quence of irreversible oxidation. Both the sulfide and sulfone have been found to have anticancer activity.3 Sulindac and its metabolites exhibit antiproliferative effects and induce apoptosis in cell culture.4

Also available: Sulindac sulfide (S8147), Sulindac sulfone (S8146)1. Reynolds PM, Rhymer AR, MacLeod MM, Buchanan WW, Curr. Med.

Res. Opin. 4:485-9 (1977). 2. Suganuma M, Ohkura Y, Okabe S, Fujiki H, J. Cancer Res.

Clin. Oncol. 127(1):69-72 (2001). 3. Soriano AF, Helfrich B, Chan DC, et al. Cancer Res. 59(24):6178-84 (1999). 4. Rahman MA, Dhar DK, Masunaga R, et al. Cancer Res. 60(8):2085-9 (2000).

Sulindac

NSAIDs are routinely used to treat joint pain

Neurobiology

Apoptosis Inhibitors can be used to treat neurodegenerative diseases

Neurobiology

AconitinePreparation of Aconitum root is

employed in Chinese and Japanese medicine for analgesic, antirheumat-ic and neurological indications.1 Its pharmacological effects are attributed to several diterpenoid alkaloids.

Aconitine (A0958), the main di-terpene alkaloid isolated from Aco-nitum roots, is known to suppress the inactivation of voltage-dependent Na+ channels by binding to neurotoxin binding site 2 of the alpha-sub-unit of the channel protein.1

Telang and Ng’ang’a claimed that 10 μg aconitine administered intraven-

tricularly in cats produced cardiac arrhythmias. They suggested

that brain stem noradrenaline

probably played a role in the centrally induced cardiac arrhythmias by aconi-tine.2

Bulleyaconitine A (B8144) is an active component isolated from Aco-nitum bulleyanum Diel. Tang, et al. found that the relative analgesic effect of bulleyaconitine A was more potent than 3-acetylaconitine, morphine and aspirin, respectively. They concluded that the analgesic effect of bulleyacon-itine A was related to the 5-HT level in brain.3

Also available: Hypaconitine (H9759), Lappaconitine (L0060)1. Ameri A. Progress in Neurobiology. 56:211-35 (1998). 2. Telang BV, Ng’ang’a JN. Indian J. Physiol. Pharma. 19:1-10 (1975). 3. Tang, XC., Liu, XJ., Lu, WH. Acta. Pharm. Sinica. 21:886-891 (1986).

CyclosporinsCyclosporin was discovered from the

fungus Tolypocladium inflatum in 1971 and its immunosuppressive activity revealed in 1976.1 28.5% are cyclic undecapeptides of fungal origin. Cyclosporin A (C9611), a cyclopeptide composed of 11 amino acids, is a leading clinical immunosuppressant. It works by selectively affecting the produc-tion of T and B lymphocytes.

At low concentration, Cyclosporin A reverts the MDR phenotype, while at high concentration it induces apoptosis through mitochondrial depolarization.2 Chronic Cyclosporin A exposure causes an increase in c-fos and c-jun mRNA and increases the renal expression of transforming growth factor-beta mRNA. Nakai and colleagues found Cyclosporin A treatment improved recovery of fetal brain energy metabolism and inhibited the mitochondrial swelling after transient in utero ischemia.3

Substitution of the L-amino-butyric acid of Cyclosporin A structure by L- Al-

aninol (A4402), L-Threonine, and L-Valine yields Cyclosporin B (C9615), Cyclosporin C (C9612), and Cyclosporin D (C9613), respectively.4 Cyclosporin H (C9614) is different from Cyclosporin A in the chiral inversion of MeVal-11 from L to D.5 It inhibits FMPL-induced superox-ide anion (O2-) formation in human neu-trophils. Cyclosporin H is a potent and se-lective formyl peptide receptor antagonist compared to cyclosporins A, B, C, D, and E.6,7 Cyclosporin C and Cyclosporin D are less potent immunosuppressive analogues of Cyclosporin A.8

1. Fenwick GR, Heaney RK, Mullin WJ. CRC Crit. Rev. Food Sci. Nutr. 18, 123-201 (1983). 2. Wattenberg LW. Carcinogenesis. 8, 1971-1973 (1987). 3. Chung FL, Jachatz A, Vitarius J, Hecht SS. Cancer Res. 44, 2924-2928 (1984). 4. Lin JM, Amin S, Trushin N, Hecht SS. Cancer Lett. 74:151-159 (1993). 5. Zhang Y, Talalay P. Cancer Res. 54(7 Suppl):1976S-1981S (1994). 6. Morse MA, Eklind KI, Amin SG, Hecht SS, Chung FL. Carcinogenesis. 10, 1757-1759 (1989). 7. Benson AM, Barretto PB. Cancer Res. 45, 4219-4223 (1985). 8. Morse MA, Amin SG, Hecht SS, Chung FL. Cancer Res. 49, 2894-2897 (1989).

Aconitine is found in the root of the Aconitum plant

Cyclosporin is found in Tolypocladium inflatum

19

Neurobiology

Fluoxetine HydrochlorideSelective serotonin re-uptake inhibi-

tors are widely used as antidepressants. They increase the level of serotonin in the brain. Serotonin is an important sub-stance necessary for the brain to func-tion. Fluoxetine HCl (F4780) is an atyp-ical selective serotonin uptake inhibitor. It has been shown to increase extracel-lular concentrations of norepinephrine and dopamine as well as serotonin in rat prefrontal cortex.1

Antidepressant drugs are reported to be used as co-analgesics in clinical man-agement of migraine and neuropathic pain. Fluoxetine-induced antinocicep-tion invloves both central opioid and the serotoninergic pathways.2 Edgar VA et al. analyzed the influence of fluoxetine on the kinases that are involved in intra-

cellular signalling after stimulation with mitogens. They concluded fluoxetine has a dual effect on T-cell proliferation by modulating the PKC and protein ki-nase A pathways through Ca2+ mobili-zation.3 Antidepressants are known to induce apoptosis in various cell types in vitro. However, experiments show fluox-etine is capable of increasing cAMP-response-element-binding-protein phosphorylation without induction of apoptosis depending on concentration and duration of treatment.4

1. Bymaster FP, Zhang W, Carter PA, et al. Psychopharmacologia. 160(4):353-361 (2002). 2. Singh VP, Jain NK, Kulkarni SK. Brain Res. 915(2):218-226 (2001). 3. Edgar VA, Sterin-Borda L, Cremaschi GA, et al. Eur. J. Pharma. 372(1):65-73 (1999). 4. Koch JM, Kell S, Aldenhoff JB. J. Psychiatr. Res. 37(1):53-59 (2003).

ZonisamideZonisamide (Z5653) is an FDA ap-

proved antiepileptic drug. Zonisamide inhibits voltage-dependent sodium channels and calcium channels of T-type.1,2,3 Zonisamide is metabolized by cytochrome P450 and has a clinically favorable long half-life (63-69 hours in healthy subjects) which allows even once-daily dosing.2 The clinical and experimental studies show zonisamide may be useful in the treatment of a wide variety of neuropathic pain syndromes or migraine prophylaxis.3

Sakaue A and colleagues found zonisamide has a preferential antinoci-ceptive action against thermal stimula-tion that is related to its local anesthetic action.4 Although psychotropic agents

are not approved for the treat-ment of obesity, they have been

used by clinicians as a thera-

peutic tool in daily clinical practice. Zonisamide is one of the central ner-vous system antiobesity agents under investigation.5

Murata reported that zonisamide has novel therapeutic effects on Par-kinson’s disease. Zonisamide increases dopamine content in the striatum by activating dopamine synthesis and the level of mRNA of tyrosine hydroxy-lase. A nation-wide double-blind con-trolled study in Japan confirmed that zonisamide improved all the cardinal symptoms of Parkinson’s disease at 50mg per day dose.6 New evidence sug-gests that Zonisamide exerts neuropro-tective properties.7

1. Faught E. Seizure. 1:S59-65 (2004). 2. Leppik IE. Seizure. 1:S5-9 (2004). 3. Sobieszek G, Borowicz KK, et al. Pol J. Pharmacol. 55(5):683-689 (2003). 4. Sakaue A, Honda M, Tanabe M, Ono H. J. Pharma. Sci. 95(2):181-188 (2004). 5. Bays HE. Obes. Res. 12(8):1197-1211 (2004). 6. Murata M. Curr. Pharm. Des. 10(6):687-693 (2004). 7. Seino M. Seizure. 1:S2-4 (2004).

Epilepsy is caused by abnormal electrical activity in the brain

Selective serotonin re-uptake inhibitors are widely used as antidepressants

20

Neurobiology

Acetylcholine Receptor BlockersThe chemical compound acetylcholine

is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms, including humans.

Acetylcholine is also the principal neu-rotransmitter in all autonomic ganglia. In the peripheral nervous system, acetylcholine ac-tivates muscles, and it is a major neurotrans-mitter in the autonomic nervous system. In the central nervous system, ACh has a variety of effects as a neuromodulator upon plastic-ity, arousal and reward. ACh has an impor-tant role in the enhancement of sensory per-ceptions when we wake up1 and in sustaining attention.2

Anisodamine (A5334) has an inhibi-tory effect on acetylcholine receptor channels,

found to inhibit Shiga toxin-1-induced cytokine production, significantly

decreasing lethality.3,4 Darifena-cin (D0169) is a medication used

to treat urinary incontenance. Darafenacin’s mechanism of action is by blocking the M3 musarinnic acetylcholine receptor.5,6,7 Ito-pride HCl (I7757) is a gastroprokinetic ben-zamide derviative that inhibits acetylcholin-esterase reversibly.8 Pancuronium bromide (P0252) is a muscle relaxant which acts as a competitive acetycholine antagonist on neu-romuscular junctions.9,10 It is also a broad-spectrum aminocyclitol antibiotic that is highly effective in the treatment of gonorrhea and has shown neuromuscular blocking activ-ity by a predominant action on acetylcholine release.1. Jones BE. Trends Pharmacol. Sci. 11:578-586 (2005). 2. Himmelheber AM, Sarter M, Bruno JP. Brain Res. Cogn. Brain Res. 3:313-325 (2000). 3. Zhang HM, Ou ZL, Gondaira F, et al. J. Lab. Clin. Med. 137:93-100 (2001). 4. Guo H, Lorenz RR, Vanhouette PM. Chin. Med. Sci. J. 7:32-35 (1992). 5. Chapple, C. Curr. Med. Res. Opin. 10:2347-2358 (2007). 6. Song P. Cancer Res. 9:3936-3944 (2007). 7. Naruganahalli KS. Eur. J. Pharmacol. 572:207-212 (2007). 8. Iwanaga Y, Kimura T, Miyashita N, et al. Jpn. J. Pharmacol. 66:317-322 (1994). 9. Stankov-Jovanovic V. Anal. Bioanal. Chem. 8:1462-1469 (2006).

GABA Related CompoundsBaclofen (B0110) is a GABA-b receptor

agonist. Buspirone Hydrochloride (B8274) is an azaspirodecanedione that has anxiolytic actions. It affects dopaminergic, serotoner-gic and noradrenergic pathways, as well as the GABA-benzodiazepine receptor chloride ionophore complex.1

Gabapentin (G0106) is an antiepi-leptic agent that is chemically related to γ-aminobutyric acid (GABA). Glipizide (G4634) is an oral hypoglycemic agent that enhances insulin secretion by inhibiting its metabolic clearance. It blocks ATP-dependent K+ channels in pancreatic b cells and brain GABA containing neurons resulting in insu-lin release.2

Ivermectin (I8618) is an anthelmintic found to be a competitive inhibitor of specific [3H]-GABA binding site in nematodes. It ac-tivates the glycine receptor chloride channel.3

Pregnenolone (P7023) is an endogenous neurosteroid that inhibits GABA-gated chlo-ride currents by enhancing receptor desensi-tization. It modulates NMDA receptors result-ing in delayed apoptotic retinal cell death and

stimulates prostate LNCaP cell proliferation through binding to the mutated androgen receptor.4

Securinine (S1609) has been found to induce apoptosis in human leukemia HL-60 cells.5

Haloperidol (H0142) is a typical antipsy-chotic that has been shown to alter GABA transporter expression in rats. It has also been shown to induce apoptosis of neurons in the striatum and substantia nigra of rat.6

Valproic acid sodium salt (V0147) is an anti-convulsant and mood stabilizing drug used for epilepsy and bipolar disorders. Mechanism of action is believed to be through the GABA neurotransmission pathways.7

1. Dringenberg HC, Kornelsen RA, Vanderwolf CH. Pharmacol. Biochem. Behav. 49:741-746 (1994). 2. Lamensdorf I, He L, Nechushtan A, et al. Eur. J. Pharmacol. 388:147-54 (2000). 3. Shan Q, Haddrill JL, Lynch JW. J. Biol. Chem. 276:12556-64 (2001). 4. Grigoryev DN, Long BJ, Njar VC, Brodie AH. J. Steroid. Biochem. Mol. Biol. 75:1-10 (2000). 5. Dong NZ, Gu ZL, Chou WH, Kwok CY. Chung Kuo Yao Li Hsueh Pao. 20:267-70 (1999). 6. Zink M, Schmitt A, May B et al. Pharmacopsychiatry. 37:171-4 (2004). 7. Quenby, S. M. Eur. J. Obstet. Gynecol.Reprod. Bio. 137:31-36 (2008).

Acetylcholine is an important neurotransmitter

GABA pathways in the brain are very important to brain function

21

Natural Products

AflatoxinsAflatoxins are mycotoxins that are

commonly produced by Aspergil-lus flavus and Aspergillus parasiticus. These molds often occur in poorly stored grains and nuts. Aflatoxins have been studied extensively because they are demonstrated to have liver carci-nogenic effects and other toxic effects in humans and animals. Chronic ex-posure to aflatoxins can lead to acute necrosis, cirrhosis and carcinoma of the liver in a number of animal spe-cies.1

Aflatoxin B1 (A2044) is a potent hepatoxin and hepatocarcinogen. The P450 enzyme system in the liver activates Aflatoxin B1 to form the carcinogenic 2,3-exo-epoxide.2 The

2,3-exo-epoxide forms a DNA ad-duct by reacting with the N7 of gua-nine.3 The product of this reaction, AfB1-N7-guanine, is believed to be responsible for the mutation, lead-ing to cancer. Aflatoxin M1 (A2052 AfM1) and Aflatoxin M2 (A2054 AfM2) are metabolites of AfB1 and AfB2, respectively. AfM1 and AfM2 are found in the milk of mammals as a result of ingestion of AfB1 contami-nated food.4

Also Available: Aflatoxin B2 (A2046), Alfatoxin G1 (A2048), Af-latoxin G2 (A2050)1. Phillips T. Tox. Sci. (52 Suppl), 118-126 (1999). 2. Croy RG, Essigmann JM, Reinhold VN, Wogan GN. Proc Natl Acad Sci. 75:1745-91978 (1978). 3. Daniels JM, Liu L, Stewart RK, Massey TE. Carcinogen-esis. 5: 823-827 (1990). 4. Unusan N. Food Chem. Toxicol. 44:1897-1890 (2006).

Marine Natural ProductsSarcophine (S0368) and 2-epi-

16-deoxysarcophine (D0368) are isolated from the Red Sea soft coral Sarcophyton glaucum.1 Cembranoid marine natural products are reported to possess cancer chemopreventive properties.2 Sarcophine was found to be an effective inhibitor of JB6 cell transformation.3 Sarcophine and 2-epi-16-deoxysarcophine are useful templates for the synthesis of more active cancer chemopreventive agents. Several studies were carried out in order to optimize their anticancer po-tential.4

Latrunculin A (L0076) is an actin-binding marine toxin isolated from

Red Sea sponge Latrunculia mag-nifica, which disrupts microfil-

ament-mediated processes.5 It is a 16-membered macrolide

attached to 2-thiazolidinone moiety.6 It inhibits actin polymerization in vi-tro and in vivo. Latrunculin A binds G-actin with moderate affinity (0.2 um), and inhibits the rate of nucleo-tide exchange.7 The structure of G-actin is altered by latruculin A binding which prevents its participation in the polymerization process.8

Also available: Okadaic acids (O4101, O4102, O4104), Manzamine A (M0255), Puupehenone (P8382)1. Sawant SS, Youssef DTA, Reiland J, et al. J. Nat. Prod. 69:1010-1013 (2006). 2. El Sayed KA, Hamann MT, Waddling CA, et al. J. Org. Chem.63:7449-7455 (1998). 3. Katsuyama I, Fahmy H, Zjawiony JK, et al. J. Nat. Prod. 65:1809-1814 (2002). 4. Sawant SS, Sylvester PW, Avery MA, et al. J. Nat. Prod. 67:2017-2023 (2004). 5. Coue M, Brenner SL, Spector I, et al. FEBS Letters. 213: 316-318 (1987). 6. Morton WM, Ayscough KR, McLaughlin PJ. Nature Cell Biol. 2: 376-378 (2000). 7. Spector I, Shochet NR, Kashman Y, et al. Science 214: 493-495 (1983). 8. Yarmola EG, Somasundaram T, Boring TA, et al. J.Biol.Chem. 275: 28120-28127 (2000).

Red Sea soft coral Sarcophyton Glaucum

Aspergillus flavus

22

Signal Transduction

Protein Kinase InhibitorsNerve Growth Factor (NGF) au-

tocrine systems are found to play an important role in the mechanisms as-sociated with psoriasis and other hyper-proliferative skin disorders such as can-cer.1 NFG up-regulates NFG mRNA in keratinocytes, which leads to keratino-cyte expression of high-affinity (TrkA) NFG-receptors in the epidermic basal layer. In the absence of exogenous NFG, K252 is an effective inhibitor of tyro-sine kinase phosphorylation, blocking high-affinity nerve receptor prolifera-tion.1

K252a (K0021) is a potent protein kinase inhibitor that has shown promise

fighting Met-driven proliferation of gastric carcinoma cells.2,3 K252b

(K0022) is an ectoprotein ki-

nase inhibitor that could have profound implications on the treatment of prostate cancer.4,5

KT5720 (K7600) is a protein kinase inhibitor that has been shown to reduce enzyme activity in INF-alpha, thereby creating a potential pathway to treat tumors.6 KT5823 (K7602) is a K252 derivative. These findings suggest that K252 derivatives (by inhibiting the phos-phorylation of tyrosine kinase) can po-tentially regulate synaptic plasticity and inhibit hyper-proliferative conditions and tumors.

1. Pincelli C, Marconi A. J. Dermatol. Sci. 22: 71-79 (2000). 2. Alessandro M, Silvia M, Paolo A, et al. Oncogene. 21(32): 4885-4893 (2002). 3. Tapley P, Lamballe F, Barbacid M. Oncogene. 7(2):371-381 (1992). 4. Ellen M-C, Kita T, Shih W, et al. Clin. Cancer Res. 6: 2309-2317 (2000). 5. Teshima, et al. J. Immunol. 159(2): 964-969 (1997). 6. Naviglio, et al. J. Interferon. Cytokine Res. 27(2):1 (2007).

CyclopamineCyclopamine (C9710) is a steroidal

alkaloid isolated from Veratrum californi-cum, and known for being a Hedgehog (Hh) signaling inhibitor. The Hh signal pathway regulates cell growth, differen-tiation, and is activated in various types of malignancies.1 Cyclopamine was found to induce apoptosis in both adenoma- and carcinoma-derived colorectal tumor cell lines, and inhibit the growth of the Hh pathway-activated breast carcinoma cells and small cell lung cancer.2 Using high po-tency Hh signal pathway antagonists such as cyclopamine to target Hh dependent tumors is a rational therapeutic approach to carcinoma.

In one study, cyclopamine prevented further injury to cholestatic livers after the blood supply was cut off then returned during the transplant procedure.3 The study provided convincing evidence cy-clopamine might protect cholestatic livers

from additional damage after a transplant procedure and improve clinical outcomes for patients.

It has also demonstrated promising ini-tial results in the treatment of psoriasis. Cyclopamine initially was shown to be ef-fective in the induction of the differentia-tion and apoptosis of basal cell carcinomas (BCCs).4

A new breakthrough isolation and pu-rification procedure by LKT Laboratories will allow us to offer 99% pure cyclopa-mine at a substantial discount to the cur-rent market price.

1. (a) Qualtrough D, Buda A, et al. International Journal of Cancer. 110(6):831-7 (2004); (b) Kubo M, Nakamura M, et al. Cancer Research 64(17):6071-4 (2004); (c) Chen JK, Taipale J, et al. Genes & Development. 16(21):2743-8 (2002); (d) Watkins DN, Peacock CD. Biochem Pharmacol. 68(6):1055-60 (2004).2. (a) Qualtrough D, Buda A, et al. International Journal of Cancer. 110(6):831-7 (2004); (b) Kubo M, Nakamura M, et al. Cancer Research 64(17):6071-4 (2004); (c) Watkins DN, Peacock CD. Biochem Pharmacol. 68(6):1055-60 (2004).3. American Chemical Society Journal Molecular Pharma-ceutics “Substance improves liver transplants” Published: June 1, 20114. http://www.cutis.com/Article.aspx?ArticleId=6424

The signal transduction cascade acts much like falling dominos

Veratrum californicum grows 1-2 meters tall and resembles a cornstalk

23

Signal Transduction

Signal Transduction

Clenbuterol Hydrochloride

Clenbuterol is a bronchodilator

Signal transduction is often described as a cascade

Clenbuterol hydrochloride (C4517) is a long-acting beta-2-ad-renergic agonist used to treat breath-ing disorders as a decongestant and bronchodilator. In dogs, oral admin-istration of clenbuterol inhibited the airway-resistance increase caused by histamine.1 In addition, clenbuterol caused heart rate increase via left ventricle pressure and arterial blood pressure decrease.1 “B2-adrenergic agonists are effective in muscle atro-phy attenuation and muscle growth induction.”2

Administration of clenbuterol in-duced muscle growth in normal rats

and attenuated muscle atrophy in rats suffering from hind-limb suspension via activa-

tion of Akt and mammalian target rapamycin (mTOR) signaling path-ways.2,3 Activation of the beta-adre-noceptors in the basolateral nucleus of the amygdala (BLA) affects memory storage.4 Post-training microinfusion of clenbuterol into the basolateral nucleus of the amygdala (BLA) in Sprague-Drawley rats enhanced reten-tion of the inhibitory avoidance task.5 Clenbuterol has also been shown to enhance memory performance in ag-ing rats and monkeys.6

1. Kato H, Nakayama K, Takata Y, et al. Arzneimittelforschung. 35:1037-41 (1985). 2. Kline WO, Panaro FJ, Yang H, et al. J. Appl. Physiol. 102:740-7 (2007). 3. Burniston JG, McLean L, Beynon RJ, et al. Muscle Nerve. 35:217-23 (2007). 4. McIntyre CK, Miyashita T, Setlow B, et. al. Proc. Natl. Acad. Sci. U. S. A. 102:10718-23 (2005). 5. Ferry B, Roozendaal B, McGaugh JL. J. Neurosci. 19:5119-5123 (1999). 6. Ramos BP, Colgan LA, Nou E, et al. Neurobiol. Aging. 7:1060-1069 (2007).

Cardiovascular

Signal-transduction cascades mediate the sensing and processing of stimuli. These mo-lecular circuits detect, amplify, and integrate di-verse external signals to generate responses such as changes in enzyme activity, gene expression, or ion-channel activity. Within cancerous cells this signal-transduction pathway is mutated or altered in such a way that the cell growth and cell cycle pathways are constitutively activated. VEGF, PDGF, EGFR and MAPK are a few of the signal transduction pathways that are integral in cancer.

VEGF and PDGF (Vascular Endothelial Growth Factor and Platelet Derived Growth Factor) are a signaling proteins produced by cells that stimulates vasculogenesis and angio-genesis. In normally functioning systems VEGF and PDGF restore oxygen supply to tissues when blood flow is inadequate. When it is over expressed and ‘on’ all the time it can contribute to disease. Solid cancers cannot grow beyond a limited size without an adequate blood supply; cancers that can express VEGF are able to grow

and metathesize. Examples of VEGF and PDGF Inhibitors are Imatinib (I4802) and Vande-tanib (V0352).

EGFR (Endothelial Growth Factor Recep-tor) is associated with a number of cancers including lung cancer. Mutations or over-ex-pression of this receptor have been implicated in about 30% of epithelial cancers. Inhibitors of EGFR prevent the binding of downstream adapter proteins. By halting the cascade n cells that rely on EGFR for growth, tumor prolifera-tion and migration is diminished. Examples of EGFR Inhibitors are Gefitinib (G1721) and Er-lotinib (E6846).

MAPK is a chain of protein in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell. A defect in the pathway leads to altered transcription of genes in the cell cycle. An example of an inhibitor associated with MAPK is Nilotinib (N3346).

24

Cardiovascular

ACE InhibitorsAngiotensin-converting enzyme

(ACE) inhibitors are used to treat hy-pertension and also can inhibit angio-genesis. Lisinopril (L3374) is an ACE inhibitor that reduces immunoreac-tive AT1-receptor expression on the neovascularized vascular endothelial cells.1 Yamaguchi et. al. found lisinopril attenuated the induction by thrombin of PDGF-A chain mRNA levels sig-nificantly in human saphenous vein endothelial cells at doses of 6-10 mol/L and 5-10 mol/L (p<0.05). They sug-gested lisinopril suppressed intimal thickening by inhibition of PDGF-A chain gene expression in endothelial

cells regrowing over vessel injury areas.2

Following establishment of

its efficacy in hypertension and conges-tive heart failure, lisinopril has been shown to reduce mortality and car-diovascular morbidity in patients with myocardial infarction when adminis-tered as early treatment.3

Enalapril (E5202) is known to re-duce the incidence of vascular demen-tia and Alzheimer’s disease.4 It is also found to have a potential for colon can-cer prevention.5

Other ACE Inhibitors:Ramipril (R0249)Temocapril HCl (T1750)Trandolapril (T6803)

1. Fujita M, Hayashi I, et al. Biochem. Biophys. Res. Comm. 294:441-7 (2002). 2. Yamaguchi M, Gallati H, Baur W, et al. Surgery. 115:495-502 (1994). 3. Goa KL, Balfour JA, Zuanetti G. Drugs. 52:564-88 (1996).4. Frishman WH. Heart Dis. 4:380-386 (2002).5. Wasumaru M, et al. Cancer Res. 63:6726-6734 (2003).

PerindoprilPerindopril (P1869) is a potent an-

giotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension, stable coronary artery disease and heart failure. Chronic treatment with this drug prevents the development of hypertension in spontaneously hypertensive rats.2 Subcutaneous injection of perindopril dramatically reduces protein expres-sion of AT1R and TGF-beta.1 It also inhibits the NF-kappaB DNA binding activity.3

Recent studies suggest that ACE inhibitors exhibit chemopreventive effects.4 Overexpression of vascular endothelial growth factor (VEGF) a potent angiogenic factor enhances tumor growth while suppression of VEGF reduces tumor growth.5 In a

study by Gilbert et al., perindopril was found to significantly decrease the overexpression of VEGF mRNA. In vitro perindopril treatment of BNL-HCC cells exhibits a marked inhibition of VEGF transcription, re-sulting in suppression of tumor devel-opment and angiogenesis.6 Because perindopril has been widely used as an antihypertensive drug, it would be an effective new approach for chemo-therapy.

1. Ajayi AA, Lees KR, Reid JL. Eur. J. Clin. Pharmacol. 30: 177-82 (1986). 2. Harrap SB, Nicolaci JA, Doyle AE. Clin. Exp. Pharmacol. Physiol. 13: 753-65 (1986). 3. Li X, Meng Y, Yang XS, Mi LF, Cai SX. World J. Gastroenterol. 11: 4807-11 (2005). 4. Lever AF, Hole DJ, Gillis CR, McCallum IR, et al. Lancet. 352: 179-184 (1998). 5. Gilbert RE, Kelly DJ, Cox AJ, Wilkinson-Berka JL, Diabetologia. 43: 1360-1367 (2000). 6. Yoshiji H, Kuriyama S, Kawata M, Yoshii J, Ikenaka Y, et. al. Clin. Can. Res. 7: 1073-78 (2001).

Perindopril is used for the treatment of high blood pressure

ACE inhibitors such as Lisinopril inhibit angiogenesis

25

Cardiovascular

Mycophenolic acidMycophenolic acid (M9710

MPA) is a natural antibiotic derived from Penicillium stoloniferum. It is an active metabolite of mycophe-nolate mofetil and is used as an im-munosuppressive drug to prevent organ rejection.1 It is a potent inhib-itor of DNA synthesis in the L strain of fibroblasts in vitro and has been found to produce strong activity against a variety of tumors in mice.2

Mycophenolic acid suppresses purine biosynthesis through the inhibition of the enzyme inosine monophosphate dehydrogenase.3 Abnormal proliferation of arterial smooth muscle cells leads to pulmo-

nary arterial hypertension (PAH). This disorder causes the blockage of blood flow to the arterioles, right ventricular hypertrophy, and death. In vitro studies have shown that MPA causes dose-dependent in-hibition of proliferation in human pulmonary arterial smooth muscle cells. These findings may present a new treatment for patients with PAH.4

1. Ginzler EM, Dooley MA, Aranow C, Kim MY, et al. N. Engl. J. Med. 353: 2219-2229 (2005). 2. Franklin TJ, Cook JM. Biochem. J. 13:515-24 (1969). 3. Franklin TJ. Biochem. J. 87:449 (1963). 4. Suzuki C, Takahashi M, Morimoto H, Izawa A, et al. Biochem. Biophys. Res. Commun. 349: 781-8 (2006).

StatinsThe statins are a group of com-

pounds primarily used as antihy-percholesterolemics.1 They are used clinically to lower plasma levels of low-density lipoprotein cholesterol. The statins are inhibitors of the enzyme 3-hydroxy-3-methylglutary-coenzyme A (HMG-CoA) reductase.2

This enzyme is responsible for the conversion of HMG-CoA to mevalon-ate, which is the rate-limiting step in the biosynthetic pathway of cholesterol. There are two main groups of statins, one of which are the fungal metabo-lites and their synthetic analogs such as Lovastatin (M1687), Simvastatin (S3449) and Pravastatin (P6801), the others are the pure synthetic ones such

as Atorvastatin (A7658), Ceriv-astatin (C1668), and Fluvas-

tatin (F4482).

In addition to their anti-hypercho-lesterolemic property, some of the statins have been found to inhibit cell proliferation,5 induce apoptosis,6 and inhibit angiogenesis.7 Lovastatin inhib-its tumor development and metastasis of fibrosarcoma and lymphoma in the rat.8 Simvastatin has been shown to en-hance the antitumor activity of BCNU (C0173)9 and have anticarcinogenic activity during the promotion phase of radiation-induced mammary tumors.10

1. Blumenthal, R.S. Am. Heart J. 139:577-83 (2000). 2. Krause, B.R., Newton, R.S. Atherosclerosis 117:237-244 (1995). 3. Kostner, G.M, Wien Med. Wochenschr. 149:120-124 (1999). 4. Bergstrom, J.D., Bostedor, R.G., Rew, D.J., et al. Biochim. Biophys. Acta 1389:213-221 (1998). 5. Park WH, Lee YY, Kim ES, et al. Anticancer Res. 19(4B):3133-40 (1999). 6. Macaulay RJ, Wang W, Dimitroulakos J, et al. J. Neurooncol. 42:1-11 (1999). 7. Feleszko W, Balkowiec EZ, Sieberth E, et al. Int. J. Cancer 81:560-567 (1999). 8. Matar, P. Rozados, V.R. et al. Cancer Biother. Radiopharm. 13:387-193 (1998). 9. Soma MR, Baetta R, De Renzis MR, et al. Cancer Res. 55:597-602 (1995). 10. Inano H. Suzuki K. Onoda M. Wakabayashi K. Carcinogenesis. 18:1723-1727 (1997).

Keeping cholesterol levels low can help reduce the possibility of blocked arteries

Mycophenolic acid is derived from Penicillium stoloniferum

26

BisphosphonatesBisphosphonates are bone resorption

inhibitors. They are modified pyrophos-phates with a P-C-P instead of P-O-P structure, which contributes to their re-sistance to enzymatic degradation and high affinity for hydroxyapatite.1 They are potent inhibitors of osteoclastic bone re-sorption and are used to treat osteoporo-sis, Paget’s disease, malignant hypercal-caemia, and bone metastasis.2 The most potent bisphosphonate is the nitrogen-containing Zoledronic acid (Z5744).3

The nitrogen-containing dronates ap-pear to have a different mechanism of action from those of the non-nitrogen-containing group. Alendronate Mono-sodium Trihydrate (A4515) and other

nitrogen-containing bisphospho-nates were found to inhibit post-translational prenylation

of proteins.4 The disruption of the mev-alonate-cholesterol synthesis pathway is mainly due to the loss of geranylgeranyl-ated proteins rather than loss of farnesyl-ated proteins in osteoclasts.5

The antitumor activity of bisphospho-nates appears to be the result of inhibi-tion of osteoclast activity and release of tumor growth factors. Cell proliferation and induction of apoptosis in human myeloma cells have been observed.6 The induction of apoptosis of ostelclast-like cells from a giant cell tumor was found to relate to the Fas gene expression.7

1. Shinoda H. Nippon Yakurigaku Zasshi 105:285-94 (1995). 2. Gatti D, Adami S. Drugs Aging. 15:285-96 (1999). 3. Body JJ. Cancer 88:3054-8 (2000). 4. Berstrom JD, Bostedor RG, et al. Arch. Biochem. Biophys. 373:231-41 (2000). 5. Coxon FP, Helfrich MH, Van’t Hof R, et al. J. Bone Miner. Res. 15:1467-76 (2000). 6. Shipman CM, Rogers MJ, Apperley JF, et al. Leuk. Lymphoma 32:129-38 (1998). 7. Wang XM, Yu SF, Yang ZP. Chin. J. Dent. Res. 3:26-32 (2000).

Proton Pump InhibitorsThe five proton pump inhibitors ap-

proved by the FDA for acid-related disor-ders treatment are Omeprazole (O4917), Lansoprazole (L0254), Rabeprazole (R0105), Pantoprazole (P0255), and Esomeprazole (E7357). Esomeprazole is the S-enantiomer of omeprazole. The hu-man clearance of proton pump inhibitors is conducted primarily by the hepatic cy-tochrome P450 system.1,2

Lansoprazole suppresses gastric acid secretion by specific inhibition of the gastric H+, K+ ATPase enzyme system of the gastric parietal cell.3 It is more effec-tive than the H2-receptor antagonists and omeprazole.4,5

Rabeprazole is a newer proton pump inhibitor with both antisecretory and gastroprotective properties.6 Because rabeprazole does not undergo hepatic biotransformation by CYP2C19, a cyto-chrome P450 isoenzyme, it offers more

rapid onset of action and more efficient acid-suppressing effect over the first-generation proton pump inhibitors such as lansoprazole and omeprazole.7

It is well known that blocking the clearance of acidic metabolites can in-duce cell death. Yeo and colleagues evalu-ated the antitumor effect of pantoprazole in a xenograft model of nude mice. They discovered pantoprazole significantly inhibited tumorigenesis and selectively induced large-scale apoptotic cell death in gastric cancer. Their experiment dem-onstrated proton pump inhibitors could be used for selective anticancer effects.8

1. Li XQ, Anderson TB, et al. Drug Metab. Dispos. 32(8):821-7 (2004). 2. Der G. Gastroenterol Nurs. 26(5):182-90 (2003). 3. El-Gindy, et al. J. Pharm. Biomed. Anal. 31: 229-242 (2003). 4. Garnett WR. Ann. Pharmacother. 30(12):1425-36 (1996). 5. Freston JW. Am. J. Med. 117(5A):14S-22S (2004). 6. Keane WF, Swan SK, et al. J. Clin. Pharmacol. 39:927-933 (1999). 7. Kinoshita Y. Aliment Pharmacol. Ther. 20(8):19-23 (2004). 8. Yeo M, Kim DK, Kim YB, et al. Clin. Cancer Res. 10(24):8687-96 (2004).

Cancerous bone cells

Micrograph of the gastric antrum showing G cell hyperplasia

27

Analytical ServicesLKT Laboratories is now offering custom analysis of your compounds us-ing our extensive range of analysis and research services for companies fo-cused on natural products.

Types of Analytical Services:

UHPLC with PDA (UV-VIS) Detection HPLC with UV, ELSD, or Mass Spec Detection GC with FID UV Spectrophotometric NMR Mass Spectroscopy

Types of Testing:

Raw Materials: Botanicals, Extracts, Intermediates, API Raw Material Blends Dietary Supplements Food and Beverages (Not GLP) Cosmetics (Not GLP) Pharmaceuticals

Testing For:

Marker compounds (Single or Multiple Compounds) Active ingredients/compounds Identity testing Qualitative analysis Metabolites

Natural Product IsolationLKT Laboratories can isolate your natural products using our high per-formance counter current chromatography instrument. This separation method has the advantage of nearly 100% sample recovery, no degrada-tion of the sample, and full polarity coverage in one single run. Separation scales can range from a few milligrams to several grams.

Custom SynthesisLKT Laboratories is fully equipped to carry out multistep organic synthesis on a milligram to kilogram scale. We fully characterize compounds and have access to modern analytical instrumentation. Quality control is per-formed in-house using UHPLC, HPLC, LC/MS, GC and NMR.

We Specialize In:

Natural Product Isolation Product Purification Total Synthesis Natural Product Analogs

Choose LKT Laboratories for your next project:

We can Cater to your Specific Needs We are Accurate and Detail Oriented High Quality Goods and Services Offer Competitive Prices and Service

High Performance Liquid Chromotography

Ultra High Performance Liquid Chromotography

Rotoevaporators for Product Synthesis

Counter Current Chromotography

Natural Product Extraction

Flash Chromotography

28

New Products

New: Kinase InhibitorsCell growth and cell cycle pathways

are constitutively activated in cancer cells. The normal controls exerted by the kinase/phosphatase enzymes no longer function. Without this regulation can-cerous cells turn on the pathway and reproduce in the absence of external sig-nals such as growth factors.

This may occur because of a mutation in a kinase or phosphatase gene. In one example, chronic myeloid leukemia, a particular chromosomal translocation has been identified that creates a novel kinase that is ‘on’ all the time. Therefore the pathway that this kinase controls is, in effect, stuck in the ‘on’ position lead-ing to unregulated proliferation of the cancerous cells.

VEGF (vascular endothelial growth factor) is a signaling protein produced by cells that stimulates vasculogenesis and angiogenesis. In normally func-tioning systems VEGF restores oxygen supply to tissues when blood flow is inadequate. When it is over expressed and ‘on’ all the time it can contribute to diseases such as angiogenesis. Solid cancers cannot grow beyond a limited size without an adequate blood supply; cancers that can express VEGF are able to grow and metathesize.

Several new cancer treatments are designed to inhibit aberrantly activated VEGF tyrosine kinases and VEGF re-ceptors within cancer cells in an effort to prevent cell division. The following drugs are kinase inhibitors used to treat cancer:1

Cediranib (C1613): is a tyrosine ki-nase inhibitor associated with the VEGF. By inhibiting the function of VEGF, which is overexpressed in tumors, Cedi-

ranib blocks cell proliferation and promotes death of cancer cells.2

Sunitinib Maleate (S8253):

inhibits cellular signaling by target-ing multiple receptor tyrosine kinases (RTKs). These include all receptors for platelet-derived growth factor (PDG-FRs) and vascular endothelial growth factor receptors (VEGFRs), which play a role in both tumorangiogenesis and tu-mor cell proliferation.3

Sorefanib (S5899): is a small molec-ular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and Raf kinases. It has been used in the treat-ment of renal and liver cancer.4

Axitinib (A9435): is a small molecule tyrosine kinase inhibitor that inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, platelet derived growth factor receptor (PDGFR), and cKIT. It has been shown to significantly inhibit growth of breast cancer in xeno-graft models. 5

Pazopanib (P0397): is a potent and selective multi-targeted receptor tyro-sine kinase inhibitor of VEGFR-1, VEG-FR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. It has been approved for renal cell carcinoma.6

Motesanib (M5876): is an orally ad-ministered small molecule antagonist of VEGF receptors, platelet-derived growth factor receptors, and stem cell factor re-ceptors.

Vandetanib (V0352): is an antago-nist of the vascular endothelial growth factor receptor (VEGFR) and the epider-mal growth factor receptor (EGFR). It is a tyrosine kinase inhibitor that is used in the treatment of non-small cell lung cancer.

1. Holmes, K., Robert, OL., Thomas, AM. Cellular Signaling 19(10): 2003-12. (2007).2. Wegge, SR., Kendrew, J., Hennequin, LF, et al. Cancer Res. 65(10): 4389. (2005).3. Hartman, JT., Kanz L. Arch Dermatol. 144(11): 1525 – 6. (2008).4. Smalley, KSM., Xiao, M., Villanueva KM. Oncogene 28: 85 – 95. (2009).5. Wilmes, LJ., Palavicini MG., Fleming LG. Magn. Res. Imaging 25(3): 319-27. (2007).6. Sleijfer, S., Ray-Coquard, I., Papai, Z. J. of Clinical Oncology 27(19): 3126. (2009).

Kinase inhibitors fit like keys into their specific molecular targets

29

New Products

New: PARP InhibitorsIniparib (I5354), Veliparib (V1745) and

Olaparib (O4402) are promising cancer chemotherapeutics in the family of PARP inhibitors for several forms of cancer in-cluding ovarian, breast, prostate and lung cancers. PARP (poly – ADP Ribose Poly-merase) is a family of proteins involved in DNA repair. Specifically PARP proteins detect single strand breaks in the DNA helix and signal to the enzymatic machinery that repairs are necessary.1

Several forms of cancer are highly depen-dent upon PARP due to their lack of other DNA repair mechanisms such as BRCA1 (Breast Cancer Type 1 Sensitive Protein) and BRCA2. BRCA1 and 2 repair double strand breaks in the DNA. A deficiency in BRCA1 or 2 can lead to an increase in mutations and thus a great risk of neoplastic cells.2

PTEN (Phosphatase and Tensin Homo-log) is another DNA repair deficient cancer

and is found in 70% of prostate cancer pa-tients. PTEN is involved in the cell cycle and prevents cells from growing and diving too rapidly. When PTEN is mutated cells are al-lowed to divide rapidly and, consequently, in conjunction with a decrease in the DNA repair protein RAD51 causes an increase in cancerous cells.3

When PARP is inhibited in these repair deficient cancer cells they are overwhelmed with double strand DNA breaks that can-not be repaired and die. Normal human cells have functioning double strand repair mechanisms and do not replicate DNA as frequently as cancerous cells; therefore they are capable of surviving where the cancer cells cannot. 1. Piskunova TS, Yurova MN, et. al., Curr Gerontol Geriatr Res. 2008: 7541902. Hall JM, Lee MK, et. al., Science 1990: 250, 1684 – 1689.3. Chu EC, Tarnawaski AS, Med Sci Monit. 2004: 10, RA235 – 241.

New: Histone Deacetylase InhibitorsHistone deacetylase inhibitors are a new

class of cytostatic agents that inhibit the pro-liferation of tumor cells in vitro and in vivo by inducing cell cycle arrest, differentiation or apoptosis. The exact mechanism of action of histone deacetylase inhibitors is unclear, however, several epigenic pathways have been proposed.1

Cells carry out gene expression by control-ling the coiling and uncoiling of DNA around histones. This is regulated by histone acety-lases, which acetylate the lysine residues upon the histone protein which leads to a looser and more transcriptionally active chromatin. Conversely, histone deacetylases remove the acetyl groups from the lysine residues and form a less active chromatin. When histone deactylase is inhibited, it induces the ac-cumulation of hyperacetylated nucleosome core histones in most regions of chromatin and affects a small subset of genes. Histone

deacetylase inhibitors can induce p21 rgene expresssion which is a regula-

tor of p53 tumor suppression activ-

ity. They also regulate retinoblastoma protein which suppresses cell proliferation. Recent data indicate that histone deacetylase inhibi-tor induced chromatin inactivation and DNA methylation are critical components of estro-gen receptor alpha silencing in human breast cancer cells.2

Vorinostat (V5734) was the first histone deacetylase inhibitor used to treat cutane-ous T-cell lymphoma. Recently, vorinostat is active in Glioblastoma multiforme, which is a lethal primary brain tumor. The average survival of glioblastoma patients is 12 – 16 months. Patients treated with vorinostat showed no tumor recurrence for 6 months of longer. Vorinostat has also been used in the treatment of non-small cell lung cancer.3

Entinostat (E5477) is another histone deacetylase inhibitor that is beneficial in the treatment of Hodgkin’s lymphoma.1. Dokmanovic M, Clarke C, Marks PA Mol. Cancer Res. 5(10):981 – 989. (2007)2. Marks PA, Richon VM, Rifkind RA J. Natl. Cancer Inst. 92(15): 1210 – 1216. (2000)3. Mayo Clinic. (Press Release), June 3rd, 2007.

Histone deacetylase

PARP proteins detect single strand breaks in the DNA helix

30

New Products

New: Fasudil HydrochlorideFasudil Hydrochloride (F0275) has

been used for more than 10 years to pro-tect the brain in stroke patients by dilating blood vessels and improving circulation. Recently, hydroxyfasudil (the metabolical-ly active form of fasudil) improved spatial learning and working memory in middle-aged rats when negotiating a complicated water maze. The implications of this re-search include enhancing learning and memory as well as prophylactically treating cognitive disorders such as Alzheimer’s.

In the study, researchers gave daily in-jections of hydroxyfasudil to middle-aged male rats, starting four days before behav-ioral testing and continuing throughout testing. The rats were then tested on a wa-

ter radial arm maze which assessed how well they remembered. The

dosed groups performed signifi-

cantly better than the control group in all of the learning and working memory tests.

Physiologically, fasudil is used to pro-tect the brain by dilating blood vessels when blood flow is curtailed. In the body, fasudil breaks down into the more potent hydroxyfasudil molecule which researchers hypothesize may alter memory by affecting the function of the KIBRA gene.

One proposed mechanism for hydroxy-fasudil interaction with KIBRA involves the ability of hydroxyfasudil to inhibit Rho-kinase. Rho kinase inhibits the vital protein Rac that supports key cellular functions. This inhibition of Rac may in turn activate the enzyme C-zeta, which may ultimately affect the KIBRA gene.

1. Huentelman, MJ Behavioral Neuroscience, 123(1):218. (2009)2. Doggerell, SA Expert Opin. Investig Drugs 14(9):1157- 1159. (2005)

New: Marine ToxinsLKT Labs has developed a partner-

ship with MARBIONC to carry their line of natural and semi-synthetic Marine Toxins.

Brevetoxins, derived from Karenia brevis, are known to bind to site 5 of voltage-gated sodium channels in nerve cells, leading to channel activa-tion. This leads to disruption of nor-mal neurological processes and causes the illness clinically described as neu-rotoxic shellfish poisoning (NSP).1

Cyanopeptolins, derived from Mi-crocystis aeruginosa, are cyclic non-ri-bosomal peptides isolated from vari-ous cyanobacteria.2 Cyanopeptolins have been reported to inhibit serine proteases such as trypsin and chymo-trypsin.3

Microginins are a class of small,

linear non-ribosomal peptides iso-lated from various cyanobacteria, primarily Microcystis aeruginosa. The microginins act as inhibitors against zinc metalloproteases such as angio-tensin-converting enzyme4 and leu-cine aminopeptidase.5

Microcystins are cyclic hybrid non-ribosomal peptide toxins iso-lated from various cyanobacteria.6

Microcystins inhibit eukaryotic pro-tein phosphatases PP1 and PP2a and are selectively transported to the liver resulting in acute liver failure and tu-mor promotion.7

1. Edwards, R. A. et al. Mol. Brain Res. (1992) 14, 64-702. Martin, C. et al. J. Antibiot. (1993) 46, 1550–1556.3. Von Elert, E. et al. J. Nat. Prod. (2005) 68, 1324–1327.4. Neumann, U. et al. FEMS Microbiol Lett. (1997) 153, 475–478.5. Kraft, M. et al. FEBS Lett. (2006) 580, 6943–6947.6. Carmichael, W. W. et al. Toxicon (1988) 26, 971–9737. Zurawell, R. et al. J. Toxicol. Env. Health B (2005) 8, 1–37.

Fasudil Hydrochloride is used as a vasodilator

Brevetoxins are derived from Karenia brevis

31

New Products

New: TigecyclineTigecycline (T3324) is the first drug in

the glycylcycline class of antibiotics. It is a structurally modified version of minocycline with expanded activity against tetracycline resistant bacteria.1

Resistant organisms are a major concern for hospital environments. Gram-positive organisms continue to increase in resistance, and very few therapeutic agents are avail-able to treat them. Available options include Vancomycin (V0252), linezolid, daptomy-cin, and quinupristin all of which have ad-verse effects that require discontinuation. Resistance normally occurs by alterations in the tetracycline efflux or ribosomal protec-tion. The glycycyclines were developed to help overcome these resistance mechanisms. The alterations to the minocycline core al-low Tigecycline to maintain activity against tetracycline-resistant organisms, icluding re-sistant gram-positive organisms such as pen-

icillin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus spe-cies.2

Tigecycline, like minocycline, binds to the bacterial 30S ribosome, blocking the entry of transfer RNA. This ultimately prevents protein synthesis by halting the incorporation of amino acids into peptide chains and thus limits bacterial growth. The addition of an N,N,-dimethylglycylamido group at the 9 position of the minocycline molecule increases the affinity of tigecycline for the ribosomal target up to 5 times when compared with minocycline or tetracycline. The allows for an expanded spectrum of activity and decreased susceptibility to the development of resistance.3

1. Garrison MW, Neumiller JJ, Setter SM. Clin. Ther. 27(1):12 – 22. 2005.2. Zhanel GG, Homenuik K, Nichol K. Drugs 64(1): 63 – 88. 2004.3. Greer ND. Pharm. Notes 19: 155 – 161. 2006.

New: PsoralenPsoralen (P7358) is the parent com-

pound in a family of compounds related to coumarin. Psoralens occur naturally in the seeds of Psoralea corlifolia, as well as in the common fig, and celery. Many furocoumarins like Psoralen are extreme-ly toxic to fish, and some are indeed used in streams in Indonesia to catch fish.

Aside from its agricultural uses pso-ralen is mainly used in PUVA (psoralen + UVA) treatment for skin problems such as psoriasis and to a lesser extent eczema and vitiligo. This takes advantage of the high UV absorbance of psoralen. The psoralen is first applied to the skin and then UVA light is used to clean up the skin problem.1

Psoralen is a mutagen that intercalates into the DNA on exposure to ultraviolet

radiation and forms covalent inter-strand cross-links with thymines

preferentially at 5’ – TpA sites in

the genome. These covalent cross-links induce apoptosis and hence cell death. It is due to this mechanism that, although PUVA treatment has shown considerable clinical efficacy, it also has a high risk of inducing skin cancer.2

Despite the mutagenic and carcino-genic properties of psoralen it has been used as a tanning activator in sunscreens until 1996. Psoralen was also synthesized and the synthetic amino-psoralen was de-veloped for the inactivation of infectious pathogens in platelet and plasma blood components prepared for transfusion surgery.2

Psoralen is biosynthesized within Pso-ralea corlifolia through the coumarins of the skikimate pathways as well as a P450 dependent monooxygenase enzyme path-way.3

1. Wu Q, Christensten LA, Legerski RJ. EMBO Rep. 6(6): 551 – 7. (2005)2. Momtaz K, Fitzpatrick TB. Dermatol Clin 16(2): 227 – 34. (1998)3. Ashwood-Smith MJ, Poulton GA, Barker M. Nature 285(5): 407 – 9. (1980).

Psoralen occurs naturally in the seeds of Psoralea corlifolia

Tigecycline was developed to fight against antibiotic resistant bacteria

32

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New ProductsA0917A0818A0919A0820A0823A0902A0910A2658A4523A4675A4678A4944A5072A6368A6933A7460A7658A9602A9603B0109B1603B1755B1652B1855B7119B1979B3577B5871B6916B7116B6917B6918B6919B7118B7016B7017B7019B7058B8248C0252C0255C0367C1613C1624C1644C1650C2943C2961C3472C3576C4556C5968C9600C9602D0262D0363D0375D1621D1761D1859D1760

1’ S-1’-Acetoxychavicol Acetate15-AcetoxyscirpenolAcetyl-L-carnitineN-Acetyl-S-(N’-benzylthiocarbamoyl)-L-cysteineN-Acetyl-S-(N’-methylthiocarbamoyl)-L-cysteineN-Acetyl-S-(N’-phenylhexylthiocarbamoyl)-L-cysteineN-Acetyl-S-(N’-phenylthiocarbamoyl)-L-cysteineAgomelatineAlfuzosin HydrochlorideAlternariolAlternariol-9-methyl etherAmlexanoxAmsacrineAprepitantAristolochic acid BAsparaginaseAtorvastatin Calcium TrihydrateAzacitidine5-Aza-2’-deoxycytidine (Decitabine)BakuchiolBeauvericinBenzimidazoleBenzo[a]pyreneO6-Benzylguaninebeta-Naphthoyl brevetoxinBetulinic acidBitertanolBortezomibBrevetoxin 1 (PbTx-1)Brevetoxin 10 (PbTx-10)Brevetoxin 2 (PbTx-2)Brevetoxin 3 (PbTx-3)Brevetoxin 3 Acetate (PbTx-3 Acetate)Brevetoxin 3-42-carboxylic acid (PbTx-COOH / BTX-5)Brevetoxin 6 (PbTx-6)Brevetoxin 7 (PbTx-7)Brevetoxin 9 (PbTx-9)Brompheniramine MaleateBumetanideCanertinib DihydrochlorideCantharidinS-(-)-Carbidopa monohydrateCediranibCefuroxime Sodium SaltCelecoxibBeta-Cembrenediol methyl esterChlorogenic acid (from Eucommia Bark)Chondroitin sulfate, chickenCisatracurium BesylateCitreoviridin AClofibric acidCordycepinCyanopeptolin 1007 (“CYP 1007”)Cyanopeptolin 1041 (“CYP 1041”)Dapiprazole HydrochlorideDaptomycinDasatinib MonohydrateDeferasirox2-Deoxy-D-glucoseDeoxynivalenol, 15-acetyl-Deoxynivalenol, 3-Acetyl-

D3200D3420D3353D5753D5868D5869D5992D6958D7992D8014E5575E5477E7578E7579E7658E8419F0275F1670F1895F3454F3473F4881F4883F4783F8147F8272G0104G0243G0245G1849G1853G3558G3552G4796G4798G4799G5875G8225H1862H1992H9614H9816H9814H9815I4659I4802I4961I5313I5354I5752I6804I6932I7256I4962I7356I7259I7360K0023K1978L0350L3453

Diacetoxyscirpenol3,4 DifluorobenzocurcuminDiminazene AceturateDonepezil hydrochlorideDoramapimodDoripenem hydrateDoxapram Hydrochloride HydrateDroloxifene citrateDTX-4DU-14EntacaponeEntinostatEstramustineEstramustine phosphate sodiumEtoposide PhosphateEverolimusFasudil HydrochlorideFerulic Acid Methyl EsterFexofenadine HClFingolimod HydrochlorideFisetinFlumequine SodiumFlutriafolFluvoxamine MaleateFulvestrantFusarenon XGabexate mesylate(-)-GallocatechinGallocatechin GallateGemifloxacin mesylateGenipin20(R)-Ginsenoside Rh220(S)-Ginsenoside Rg3Glycerol MonolaurateGlyciteinGlycitinGossypol-acetic acidGuggulsteroneHeptaplatinHexaconazoleHydrochlorothiazide2-Hydroxy Estradiol25-Hydroxyvitamin D225-Hydroxyvitamin D3IloperidoneImatinib mesylateImperatorinIndinavir SulfateIniparibIonomycin free acidIrbesartanIrinotecanIsobavachalconeIsoimperatorinIsopropyl ThiogalactosideIsoproterenol HydrochlorideIsosorbide MononitrateK252CKetorolac TromethamineLamivudineLinezolid

L5750L5751L5862L5870M0114M0255M0374M1746M2076M1678M1878M1875M1975M3410M3408M3208M3308M3210M3312M3212M5876M8007N1744N1858N3301N3208N3422N3323N3584N5605O4200O4202O4204O4402O4531O4532O6805O9458O9596O9702P0013P0397P1200P1202P3209P3210P3348P3592P2512P2514P2516P2522P6232P7060P7058P7057P7219P7358P7359P8382R0109

LomeguatribLomerizine HydrochlorideLopinavirLornoxicamMadecassic acidManzamine AMasitinibMelphalanMetformin Hydrochloride2-Methoxy estradiol16-O-MethylkahweolS-(N-Methylsulfinylbutylthiocarbamoyl)-glutathioneS-(N-Methylthiocarbamoyl)-L-cysteineMicrocystin (N-methyl-L)R (“MC(N-Me)LR”)Microcystin LR, desmethyl (“Asp3-MCLR”)Microginin 527Microginin 527 methyl esterMicroginin 690Microginin 690 methyl esterMicroginin 704MotesanibMubritinib, Free baseNelarabineNeosolaniolNiacinNicardipineNifekalant HydrochlorideNifuratelNivalenolNobiletinOkadaic acid C8 diol esterOkadaic acid methyl esterOkadaolOlaparibOligomycin AOligomycin BOrbifloxacinOxolinic acidOxybutynin HClOzagrel HClP7C3PazopanibPD184352PD325901PiceatannolPicoplatinPimecrolimusPixantrone DimaleateS-(N-Phenethylthiocarbamoyl)-L-cysteineS-(N-Phenylbutylthiocarbamoyl)-glutathioneS-(N-Phenylbutylthiocarbamoyl)-L-cysteineS-(N-Phenylthiocarbamoyl)-glutathionePP1Protocatechuic acid ethyl esterProtocatechuic aldehydeProtodioscinPseudolaric Acid BPsoralen (Ficusin)PsoralidinPuupehenoneRacecadotril

R0248R0348R1977R1978R3577R3584R5722R5773R5772R5878R8179S0044S0045S0168S1971S3313S3346S3476S3584S5869S6235S7701S8098T0249T1733T1844T1854T1855T1952T1776T2935T2932T2528T2936T3134T3324T3468T5996T7134T7132U6801V0244V0146V0352V1745V1868V3345V5886V5734W2933Z0252Z1970Z3463

RamatrobanRamelteonRetigabineRetigabine DihydrochlorideRitonavirRivaroxabanRofecoxibRosiglitazoneRosiglitazone MaleateRotenoneRutaecarpine (synthetic)Salbutamol free baseSalbutamol SulfateSaracatinibSertraline HClSildenafil CitrateSilodosinSitagliptin Phosphate MonohydrateSivelestat Sodium TetrahydrateSorafenib TosylateSpironolactoneStanozololSU-1498TamibaroteneTeicoplaninTelbivudineTenofovir MonohydrateTentoxinTenuazonic acidD-TetrahydropalmatineThiamphenicolThiamphenicol Glycinate HClS-(N-Thienylmethylthiocarbamoyl)-L-cysteineThioridazine HydrochlorideThiostreptonTigecyclineTirapazamineTozasertibtrans-3,4’,5-Trimethoxy-stilbeneTriacetyl ResveratrolUrapidilValganciclovir HydrochlorideValsartanVandetanibVeliparibVeratramineVildagliptinVoriconazoleVorinostatWHI-P131ZanamivirZerumboneZiprasidone


New Products


Tel: 888-558-5227Fax:

Email: [email protected]: www.lktlabs.com

Alphabetical Listingof our

Specialty Chemicals

651-644-8357



A0099 A-779 1 mgC39H60N12O11 FW 872.99 2 mg

H-Asp-Arg-Val-Tyr-lie-His-D- A potent and selective antagonist for the heptapeptide angiotensin- 5 mgAla-OH (1-7)[ANG-(1-7)]. It prevents ANG-(1-7)-induced inhibition of angiogenesis.

Santos, R.A; Campagnole-Santos, M.J.; Baracho, N.C., et.al. Brain Res. Bull 35:293-298 (1994).Machado,R.D.;Santos,R.A.,Andrade,S.P.Amer.JPhysio-Reg. Integ.&Comp.Physio280:R994-RR1000(2001).

A23187, Free acid (See Calcimycin)

A0101 A23187, 4-Bromo 1 mg4-Bromo-A-23187, 4-BrA23187, 4-Bra23187 5 mgC29H36BrN3O6 FW 602.52 [76455-82-8]A halogenated analogue of A23187. It is a nonfluorescent Ca2+ ionophore used in calibration

for determining cytoplasmic Ca2+ by fluorescent probes.Deber CM., Tom-Kun J., Mack E., Grinstein S. Anal Biochem 146: 349-352 (1985)

A0102 A23187, Ca-Mg 5 mg(C29H36N3O6)2Mg, (C29H36N3O6)2Ca FW 523.62 10 mgA calcium, magnesium salt of A23187, a calcium ionophore used to increase intracellular

calcium levels in cells.

Mickelson et.al. Arch Biochem Biosphys. 242: 127-136 (1985).

Andersson D, Zygmunt P, Movahed P, Anderson T, Hogestatt E. Br J Pharmacol. 129: 1490-6 (2000)0

A0025 17-AAG 0.5 mg17-(Allylamino)-17-desmethoxy-geldanamycin; allylaminogeldanamycin 1 mgC31H43N3O8 FW 585.69 [75747-14-7] 5 mgAn anologue of geldanamycin. It is a Hsp90 antagonist that induces apoptosis in human leukemiacells. It has been shown to enhance paclitaxel-mediated cytotoxicity and downregulate vascular endothelial factor expression.Rahmani M, Yu C, Dai Y et al. Cancer Research. 63:8420-7 (2003).

Nguyen DM, Lorang D, Chen GA et al. Annals of Thoracic Surgery. 72:371-8 (2001).

A0501 Abamectin 1 g[71751-41-2] 5 gAn insecticide and antihelmintic agent made up of a mixture of avermectins. 25 gLasota JA, Dybas RA. Acta Leidensia. 59:217-225 (1990)

Ali A, Nayar JK. J Am Mosquito Control Assoc. 1:384-386 (1985).

A0802 Acarbose 1 gC25H43NO18 FW 645.60 [56180-94-0] 5 gAn α-glucosidase inhibitor that inhibits sucrose digestion in rats. 25 gIt has been found to reduce the risk of cardiovascular disease and hypertension.

Krause HP, Keup U, Puls, W. Digestion. 23:486-94 (1982).

Chiasson JL, Josse RG, Gomis R et al. JAMA. 23:486-94 (2003).

A0812 Ac-D-E 5 mgAc-Asp-Glu-OH C11H16N2O8 FW 304.3 [3106-85-2] 10 mg

25 mg

A1017 Aceclofenac 5 gC16H13Cl2NO4 FW 354.18 [89796-99-6] 25 gA non-steroidal anti-inflammatory drug. It possesses potent inhibitory activity 100 gin several models of acute and chronic inflammation. It has a more favorable therapeutic

ratio compared to indomethacin, diclofenac, naproxen, and phenylbutazone.Yamazaki R, Kawai S, Matsuzaki T et al. Eur J Pharmacol. 329:181-7 (1997).Grau M, Guasch J, Montero JL et al. Arzneimittelforschung. 41:1265-76 (1991).

A0816 Acemetacin 1 gC21H18ClNO6 FW 415.82 [53164-05-9] 5 gA derivative of indomethacin. Used as an anti-inflammatory drug. It is as potent as indomethacin

as an inhibitor of COX-2, but less active on COX-1. It has been found to have anti-tumor activity inthe colon of mice.Tavares IA, Bennett A. Int. J Tisssue Reactions. 15:49-53 (1993).Kisara S, Maekawa I, Sasaki K et al. Res. Comm. Chem Path. Pharm. 81: 247-250 (1993).


A0817 D,L-1'-Acetoxychavicol Acetate (See page 5 for info) 25 mgC13H14O4 FW 234.25 [52946-22-2] 100 mgA xanthine oxidase inhibitor shown to possess chemopreventive 250 mgpotential against both oral and colonic tumorigenesis in rats.

Ohnishi M, Tanaka T, Makita H et al. Jpn J Cancer Res. 87:349-356 (1996).

Tanaka T, Makita H, Kawamori T et al. Carcinogenesis. 18:1113-1118 (1997).

A0917 1'S-1'-Acetoxychavicol Acetate (See page 5 for info) 10 mgC13H14O4 FW 234.25 25 mgA natually occurring xanthine oxidase inhibitor isolated from a. galanga. It has been 100 mgshown to possess chemopreventive potential against both oral and colonic tumorigenesis in the rat.Ohnishi M, Tanaka T, Makita H et al. Jpn J Cancer Res. 87:349-356 (1996).

Tanaka T, Makita H, Kawamori T et al. Carcinogenesis. 18:1113-1118 (1997).

A0818 15-Acetoxyscirpenol 1 mgC17H24O6 FW 324.37 [2623-22-5] 5 mgA trichothecene mycotoxin and apoptosis inducer.

Kidd MT, Hagler WM Jr, Qureshi MA. Immunopharmacol Immunotoxicol. 17(2):385-98 (1995).

A0921 N-Acetyl-D-Leucine 1 gC8H15NO3 FW 173.21 [19764-30-8] 5 gAmino Acid

A0919 Acetyl-L-Carnitine 1 gC9H17NO4 FW 203.24 [3040-38-8] 5 gAn acetylated form of L-carnitine. It is a dietary supplement and naturally

occurs in plants and animals.Rebouche CJ. Ann. N.Y. Acad. Sci. 1033:30-41 (2004).

A0918 N-Acetyl-L-Cysteine 10 gC5H9O3S FW 163.19 m.p. 109-111oC [616-91-1] 25 gAn antioxidant, that is effective in the early stages of carcinogenesis.

Bongers V, deJong J, Steen I, De Vries N, Bast A, Snow GB, BraakhuisB.J.EurJ.CancerA(6):921-923(1995).

A0820 N-Acetyl-S-(N'-benzylthiocarbamoyl)-L-cysteine 10 mgC13H16N2O3S2 FW 312.41 25 mgA cysteine conjugate of benzyl isothiocyanate. 100 mg

A0823 N-Acetyl-S-(N'-methylthiocarbamoyl)-L-cysteine 10 mgC7H12N2O3S2 FW 236.31 25 mgA cysteine conjugate of methyl isothiocyanate. 100 mg

A0920 N-Acetyl-S-(N'-phenethylthiocarbamoyl)-L-cysteine 25 mgC14H18N2O3S2 FW 326.44 100 mgPhenethyl isothiocyanate N-acteyl-L-cysteine conjugate; PEITC N-acetyl-L- 500 mgcysteine conjugate.

A0902 N-Acetyl-S-(N’-phenylhexylthiocarbamoyl)-L-cysteine 10 mgC18H26N2O3S2 FW 382.54 25 mgA cysteine conjugate of phenyl isothiocyanate. 100 mg

A0910 N-Acetyl-S-(N’-phenylthiocarbamoyl)-L-cysteine 10 mgC12H14N2O3S2 FW 298.38 25 mgA cysteine conjugate of phenyl isothiocyanate. 100 mg

A0819 Acetylsalicylic Acid / Aspirin 500 gC9H8O4 FW 180.16 [50-78-2] 1 kgNon-steroidal anti-inflammatory agent. Has undergone clinical trials as a chemopreventive agent.Kelloff GJ, Boone CW, Crowell JA et al. Cancer Epidemiol. Biomarkers Prev 3:85-98 (1994).

NH

HO

O

O

NO

OO

O

O

OH

HS

NH

O

NH

S

O OH

HN

S

O


A0825 Ac-GPK-pNA 25 mgAc-Gly-Pro-Lys-PNA C21H30N6O6 FW 462.50

A0826 Ac-GPK(Ac)-pNA 25 mgAc-Gly-Pro-Lys(Ac)-PNA C23H32N6O7 FW 504.50

A0832 Ac-IEAR-pNA 25 mgAc-lle-Glu-Ala-Arg-PNA.HCl C28H43N9O9 FW 649.70

A0834 Ac-IETD-pNA 25 mgAc-lle-Glu-Thr-Asp-PNA C27H38N6O12 FW 638.6

A0833 Acipimox 1 gC6H6N2O3 FW 154.12 [51037-30-0] 5 gAcipimox inhibits lipolysis in peripheral tissues and induces large reduction in 10 gcirculating serum-free fatty acids. The mechanism of triglyceride lowering appears to

be an increase of VLDL-Tg clearance.

Nuutinen J, Minn H, Bergmand J et al. Br J. Cancer. 80:513-518 (1999).

Hannah JS, Bodkin NL, Paidi MS et al. Acta Diabetol. 32:279-283 (1995).

A0934 Acivicin (See page 6 for more information) 10 mgC5H7ClN2O3 FW 178.57 [42228-92-2] 25 mgA specific inhibitor of γ -glutamyl transpeptidase and transmembrane 100 mg glutathione transport. Potent antitumor and antileishmania agent. Induces apoptosis in human lymphoblastoid cells.Griffith OW et al. Proc. Natl. Acad. Sci. USA 77:3384 (1980).

Earhart RH et al. Adv. Enzyme Regulation 24:179 (1986).

Mukherjee T et al. Biochem. Biophys. Res. Commun. 170:426 (1982).

Graber R, Losa GA. Int. J. Cancer. 62:443-8 (1995).

A0958 Aconitine (See page 19 for more information) 10 mgC34H47NO11 FW 645.74 [302-27-2] 25 mgA diterpene alkaloid isolated from Aconiti Carmichaeli Praeparata used to 100 mginduce cardiac arrhythmias. It binds to neurotoxin binding site 2 of the alpha-

sub-unit of the Na+ channel protein.

Telang BV, Ng'ang'a JN. Ind J Phy Pharm. 19:1-10 (1975).

Ameri A. Prog Neurobiol. 56:211-235 (1998).

Acrinol (See Ethacridine lactate monohydrate)

A0960 ACTH (1-39), human 1 mgC207H308N56O58S FW 4541.1 [12279-41-3]

Adrenocorticotropic hormone.

A0961 ACTH (1-39), rat 0.5 mgC210H315N57O57S FW 4582.3 1 mgAdrenocorticotropic hormone. 2.5 mg

A0962 ACTH (1-4) 1 mgH-Ser-Tyr-Ser-Met-OH C20H30N4O8S FW 486.6 2 mg

Adrenocorticotropic hormone. 5 mg

A0963 ACTH (1-10), human 1 mgC59H78N16O16S1 FW 1299.4 2 mgAdrenocorticotropic hormone. 5 mg

A0964 ACTH (1-13), human 0.5 mgC75H106N20O19S1 FW 1623.9 1 mgAdrenocorticotropic hormone. 2.5 mg

HO

H3CO

OH

O

CH3O

OCH3

OCH3 O

NOH

O

OCH3

H3C

H-Ser-Tyr-Ser-Met-Glu-His-Phe-

Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-

Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-

Pro-Asn-Val-Ala-Glu-Asn-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH


Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-

Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-

Pro-Asn-Gly-Ala-Glu-Asp-Glu-

Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH


Arg-Trp-Gly-OH


Arg-Trp-Gly-Lys-Pro-Val-OH


A0965 ACTH (1-14) 1 mgC77H169N21O20S1 FW 1680.9 2 mgAdrenocorticotropic hormone. 5 mg

A0966 ACTH (1-16), human 0.5 mgC89H133N25O22S FW 1937.27 1 mgAdrenocorticotropic hormone. 2.5 mg

A0967 ACTH (1-17), human 0.5 mgC95H145N29O23S FW 2093.5 1 mgAdrenocorticotropic hormone. 2.5 mg

A0968 ACTH (1-24), human 0.5 mgC136G210N40O31S FW 2933.5 1 mgAdrenocorticotropic hormone. 2.5 mg

A0971 ACTH (4-10), human 1 mgC44H59N13O10S1 FW 962.1 2 mgAdrenocorticotropic hormone. 5 mg

A0970 ACTH (18-39), human 1 mgC112H165N27O36 FW 2465.7 2 mgAdrenocorticotropic hormone. 5 mg

A0977 Actinomycin D 5 mgDactinomycin 10 mgC26H86N12O16 FW 1255.4 m.p. 241-243oC [50-76-0]An antibiotic from Streptomyces. Has antineoplastic activity.

Hennings H, Boutwell RK. Life Sci., 6:173-181 (1967).

Harris CC. Cancer. 37 (2 Suppl):1014-1023 (1976).

Actinomycin D, 7-Amino (See 7-Amino-Actinomycin)

A0978 Actinonin 5 mgC19H35N3O5 FW 385.50 [13434-13-4]A naturally occurring antibacterial agent that is a potent peptide deformylase (PDF) inhibitor.It has shown dose-dependent antitumor effects on AKR leukemia in vivo.Xu Y, Lai LT, Gabrilove JL, et al. Clinical Cancer Research. 4:171-6 (1998).

Chen DZ, Patel DV, Hackbarth CJ et al. Biochemistry. 39:1256-62 (2000).

A1084 Ac-VEID-pNA 25 mgAc-Val-Glu-lle-Asp-PNA C28H40N6O11 FW 636.6

A1096 Acycloguanosine 50 mgAcyclovir 100 mgC8H11N5O3 FW 225.20 m.p. 256.5-257oC [59277-89-3] 500 mgAn orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Elion GB et al. Proc Nat Acad Aci USA. 74:5716 (1977).

Acyclovir (See Acycloguanosine)

A1097 Ac-YVAD-pNA 25 mgAc-Tyr-Val-Ala-Asp-PNA C29H36N6O10 FW 628.6

A1202 Adapalene 100 mgC28H28O3 FW 412.52 [106685-40-9] 250 mgA moderator of cellular differentiation and inflammatory processes. Marketed 1 gunder the trade name Differin. A topical retinoid.Horie, T. et. al. Jpn. Kokai Tokkyo Koho (2008),

Kawashima, M. J. Dermatological Science (2008), 49(3), 241-248.

Tenaud I. Experimental dermatology (2007), 16(6), 500-6


Arg-Trp-Gly-Lys-Pro-Val-Gly-

OH



Lys-Lys-OH



Lys-Lys-Arg-OH



Lys-Lys-Arg-Arg-Pro-Val-Lys-

Val-Tyr-Pro-OH

H-Met-Glu-His-Phe-Arg-Trp-Gly-

OH

H-Arg-Pro-Val-Lys-Val-Tyr-Pro-

Asn-Gly-Ala-Glu-Asp-Glu-Ser-

Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH


A1318 Adenine 10 gC5H5N5 FW 135.13 [73-24-5] 25 gInhibits HL-60 cell growth by induction of apoptosis. Also induces

selective apoptosis toward MOLT4/HIV cells.

Tanaka Y, Yoshihara K, Tsuyuki M, Kamiya T. Exp. Cell Res. 213:242-52 (1994).

Hirasawa K, Yoshida O, Fujunami T et al. Biochem Biophys Res Commun. 273:1025-32 (2000).

A1319 Adenosine Triphosphate Disodium 1 gATP 5 gC10H16N5Na2O13P3 FW 551.14 [987-65-5] 10 gA P2 purinergic agonist, it increases activity of Ca2+ activated K+ channels. 25 gArkhammar P, Hallberg A, Kindmark H et al. Biochem J. 265:203-11 (1990).

Jaffar ZH, Pearce FL. Agents Actions. 40:18-27 (1993).

A1330 Adipokinetic Hormone 1 mgC44H60N10O12 FW 921.0 2 mgAdipokinetic hormones are neurohormones that regulate the metabolism of 5 mgcarbohydrates and lipids during flight and locomotion.

Stone, J.V. Mordue, W. Batley, K.E., Morris, H.R. Nature 263:207-211 (1976).

Robinson, NL., Goldsworthy, G.J. J. Insect Physiol 23:9-16 (1977).

A1331 Adipokinetic Hormone, AKH, locust 1 mgC54H74N14O15 FW 1159.3 2 mg

5 mg

A1332 Adipokinetic Hormone II from Locusta migratoria 1 mgC43H58N11O11 FW 903.9 2 mgA grasshopper neuropeptide. 5 mgNoves BE, Schaffer MH. DNA Cell Biol. 12(6):509-516 (1993).

A1333 Adipokinetic Hormone II from Schistocera gregaria 1 mgC44H60N11O12 FW 934.02 2 mg

5 mg

A1368 Adrenomedullin (1-52), human 0.5 mgC264H406N80O77S3 FW 6028.9 1 mgA potent vasodilating peptide found in human pheochromocytoma from the 2.5 mg adrenal medulla. Intravenous administration of adrenomedullin resulted in a

significant decrease in blood pressure along with total peripheral resistance.

Perret M. et. al. Life Sci. 53: 377-9 (1993).

Ishiyama Y. et. al. Eur J Pharmacol. 241:271-3 (1993).

A1369 Adrenomedullin (13-52), human 0.5 mgC200H308N58O59S2 FW 4533.17 1 mg

2.5 mg

A1370 Adrenomedullin (22-52), human 0.5 mgC159H252N46O48 FW 3576.06 1 mg

2.5 mg

A1371 Adrenorphin 1 mgC44H69N15O9S FW 984.2 2 mg

5 mg

Adriamycin (See Doxorubicin HCl)

pGlu-Leu-Thr-Phe-Thr-Ser-Trp-

Gly-NH2

pGlu-Leu-Asn-Phe-Ser-Ala-Gly-

Trp-NH2

H-Tyr-Arg-Gln-Ser-Met-Asn-Asn-

Phe-Gln-Gly-Leu-Arg-Ser-Phe-

Gly-Cys-Arg-Phe-Gly-Thr-Cys-

Thr-Val-Gln-Lys-Leu-Ala-His-Gln-

Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-

Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-

Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2

(Disulfide Bridge Cys16-Cys21)

H-Ser-Phe-Gly-Cys-Arg-Phe-Gly-

Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-

His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-

Lys-Asp-Lys-Asp-Asn-Val-Ala-

Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-

Gly-Tyr-NH2


H-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-

Ile-Try-Gln-Phe-Thr-Asp-Lys-Asp-

Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-

Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2

H-Arg-Pro-Val-Lys-Val-Tyr-Pro-

Asn-Gly-Ala-Glu-Asp-Glu-Ser-

Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH

pGlu-Leu-Asn-Phe-Ser-Ala-Gly-

Trp-NH2

H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-

Val-NH2

HN

N

N

N

NH2


A1865 Aeroplysinin 100 µgC9H9Br2NO3 FW 338.98 [28656-91-9] 5 x 100 µgA naturally occurring tyrosine metabolite from the marine sponge 1 mgVerongia aerophoba. It has been shown to interfere with key events in angiogenesis

and displays a strong anti-tumor effect on epidermal growth factor dependent tumor lines.

It has also been shown to have antileukemic acivity.Rodriguez S, Gonzalez M, Carmona R, et al. FASEB Journal. 16:261-3 (2002).Kreuter MH, Leake RE, Rinaldi F, et al. Comparative Biochem. 97:151-8 (1990).Kreuter MH, Bernd A, Holzmann H, et al. Journal of Biosciences. 44:680-8 (1989).

A2044 Aflatoxin B1 (See page 22 for more information) 1 mgC17H12O6 FW 312.27 [1162-65-8] 5 mgA potent hepatoxin and hepatocarcinogen oxidizes to form the carcinogenic, 2,3-exo-epoxide.

Chronic exposure produces necrosis, cirrhosis, and carcinoma of the liver.

Phillips, T., Tox. Sci. (52 Suppl), 118-126 (1999).

Daniels JM, Liu L, Stewart RK, Massey TE. Carcinogenesis. 5: 823-827 (1990).

A2046 Aflatoxin B2 (See page 22 for more information) 1 mgC17H14O6 FW 314.229 [7220-81-7] 5 mgA potent hepatoxin and hepatocarcinogen found in poorly stored grains and nuts.

Chronic exposure is shown to produce mutagenesis, necrosis, and liver carcinogenesis.

Phillips, T., Tox. Sci. (52 Suppl), 118-126 (1999).

Daniels JM, Liu L, Stewart RK, Massey TE. Carcinogenesis. 5: 823-827 (1990).

A2048 Aflatoxin G1 (See page 22 for more information) 1 mgC17H12O7 FW 328.27 [1165-39-5 ] 5 mgA mycotyxin produced by aspergillus parasiticus.A toxic and carcinogenic mycotoxin that induces mutation of human chromosomes by forming guanyl-N7 adducts in liver DNA.el-Zawahri MM, Morad MM, Khishin AF. J Environ Pathol Toxicol Oncol. 10:45-51 (1990).

Baertschi SW, Raney KD, Shimada T, Harris TM, Guengerich FP. Chem Res Toxicol. 2:114-2 (1989).

A2050 Aflatoxin G2 (See page 22 for more information) 1 mgC17H14O7 FW 330.29 [7241-98-7] 5 mgA mycotyxin produced by aspergillus parasiticus. Binds to DNAse II, exhibits inhibition effects.

Lotter LH, Schabort JC. Int J Biochem. 15:817-25 (1983).

A2052 Aflatoxin M1 (See page 22 for more information) 100 µgC17H12O7 FW 328.27 [6795-23-9] 1 mgA potent hepatotoxic mycotyxin metabolite of Aflatoxin B1. Often found in milk of

cattle fed on AfB1 contaminated feed. Exhibits cytotoxic activities.Neal G, Eaton D, Judah D, Verma A. Toxicol Appl Pharmacol. 151:1582-8 (1998).

A2054 Aflatoxin M2 (See page 22 for more information) 100 µgC17H14O7 FW 330.29 1 mgMetabolite of Aflatoxin B2, which is found in milk of cattle fed on AfB2.Purchase, I, Food Cosmet Toxicol. 5:339-42 (1967).

A2412 A-G-D-V 5 mgH-Ala-Gly-Asp-Val-OH C14H24N4O7 FW 360.37 10 mg

25 mg

A2658 Agomelatine 50 mgC15H17NO2 FW 243.30 [138112-76-2] 100 mgAgomelatine is a melatonin receptors (MT1 and MT2) agonist and 5-HT2C 500 mgantagonist.De Bodinat C, Guardiola-Lematire B, Mocaer E, et al Nat Rev Drug Dis 9:628-642 (2010).

A4369 A-K-R-R-R-L-S-S-L-R-A 1 mgC54H104N24O14 FW 1313.58 2 mg

5 mgH-Ala-Lys-Arg-Arg-Arg-Leu-Ser-Ser-Leu-Arg-Ala-OH

O

O

O

O

OCH3

O

O

H

H

O

O

O

O

OCH3

O

O

O

O

O

OO

OCH3

H

H


A4401 A-L-A-L 1 mgH-Ala-Leu-Ala-Leu-OH C18H34N4O5 FW 386.5 2 mg

5 mg

A4400 Alamethicin 1 mgC92H150N22O25 FW 1964.4 [27061-78-5] 5 mgAlamethicin is a channel-forming ionophore. It activates membrane enzymes by

disrupting the membrane barriers of sarcolemmal vesicles, which gives substrates

and activators access to enzymatic sites in the interior of the vesicles.

Jones, L.R., Maddock, S.W., Besch , H.R. Jr. J. Biol. Chem. 255:9971-9980 (1980).

A4402 L-Alaninol (See page 19 for more information) 1 gS(+)-2-Amino-1-propanol 10 gC3H9NO FW 75.11 [2749-11-3] m.p. 173-176oC [α]D=+18.0 An amino acid alcohol with anti-proliferative effect.

Landau O, Wasserman L, Deutsch AA. Cancer Lett. 69:203-8 (1993).

A4403 Alarelin Acetate Please inquireC56H78N16O12 FW 1167.3 [79561-22-1]A gonadotropin-releasing hormone analogue shown to inhibit DNA synthesis and poliferation of

rat gastric smooth muscle cells through GnRH receptors in vitro.

Chen L, He HX, Sun XD, Zhao J, Liu LH, Huang WQ, Zhang RQ. World J Gastroenterol. 10:1780-4 (2004).

A4606 Albendazole 10 gMethyl-5(propylthio)-2-benzimidazolecarbamate 50 gC12H15N3O2S FW 265.33 m.p. 208-210oC [54965-21-8]

Albendazole sulfoxide (See Ricobendazole)

A4515 Alendronate Monosodium Trihydrate (See page 27) 100 mgC4H12NNaO7P2

.3Η2Ο FW 325.08 500 mgA second generation bisphosphonate used as bone resorptive inhibitor. It induces apoptosis of rabbit

osteoclasts, human osteoclastoma-derived isteiclasts and human osteollclast-like cells

in vitro. The promotion of apoptosis of OCLs is related to the expression of FAS gene.

Woo T, Adachi JD. Baillieres Best Pract Res. Clin Rheumatol. 15:469-81 (2001).

Benford HL, McGowan NW, Helfrichg MH et al. Bone 28:465-73 (2001).

Wang XM, Yu SF, Yang ZP. Chin J Dent Res. 3:26-32 (2000).

A4521 Alfacalcidol 1 mgC27H44O2 FW 400.64 [41294-56-8] 5 mgA bone resorption inhibitor. Has shown antitumor activity in non-Hodgkin's lymphomas.

Cunningham D, Gilchrist NL, Cowan RA et al. Brit Med J Clin Res. 291:1153-1155 (1985).

Shiraki M, Fukuchi M, Kiriyama T. J Bone Miner Metab. 22:352-359 (2004).

A4523 Alfuzosin Hydrochloride 100 mgC19H27N5O4

.ΗCl FW 425.91 [81403−68−1] 500 mgAn α1 receptor antagonist used to treat benign prostatic hyperplasia (BPH). 1 gGuerre A, Hartl DM, Katz P. Rev Stomatol Chir Maxillofac. 111(3):135-9 (2010).

A4438 Allatostatin I 1 mgC61H94N18O16 FW 1335.54 2 mgA neuropeptide that inhibits juvenile hormone synthesis in insects. Its inhibitory 5 mgregulation of intestinal muscles, it was also found to modulate skeletal neuromuscular events.

Woodhead, AP., Stay, B, Seidel, SL, et al Proc. Natl. Acad. Sci.USA 86:5997-6001 (1989).

Kreissl, S. Weiss, T., Djokaj, S. Et al. Eur. J. Neurosci. 11:2519-2530 (1999).

N

HN

S

NHCOCH3

O

H3C

Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phl

Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH

H-Ala-Pro-Ser-Gly-Ala-Gln-Arg-Leu-Tyr-Gly-Phe-Gly-Leu-NH2

ONa

P

NH2

P

HO

HO

O

HO OH

O

.3 H20


A4440 Allicin 1 mgC6H10OS2 FW 162.27 [539-86-6] 5 mg10 mg/ml methanol/water/formic acid (60:40:0.1)The main biologically active compound in garlic. It exerts various biological effects, including

antiproliferative, chemopreventive, antioxidant, antihyperlipidaemic and antihypertensive effects.

It has been shown to inhibit the growth of cancer cells of murine and human origin in addition to

inhibiting telomerase activity and inducing apoptosis in gastric SGS-7901 cells.

Sela U, Ganor S, Hecht I et al. Immunology. 11:391-9 (2004).

Oommen S, Anto RJ, Srinivas G et al. Eur J Pharmacol. 485:97-103 (2004).

Sun L, Wang X. World J Gastroenterol. 9:1930-4 (2003).

A4443 L(+) Alliin 25 mg3-(2-Propenylsulfinyl) alanine 50 mgC6H11NO3S FW 177.22 m.p. 163-1650C [α]D+60o 100 mgOptically pure form of alliin.

A4444 L(±) Alliin 100 mg3-(2-Propenylsulfinyl) alanine 500 mgC6H11NO3S FW 177.22 m.p. 163-165oC 1 gRacemic mixture

A4445 Allopurinol 5 g4-Hydroxypyrazoleo [3,4-d]pyrimidine 10 gC5H4N4O FW 136.11 m.p. >350oC [315-30-0]An isomer of hypoxanthine. It is a potent xanthine oxidase inhibitor.Kelley WN, Beardmore TD. Science, 169:388-390 (1970).

Marchmont RJ, Houslay MD. Biochem J. 195:653-660 (1981).

Weber G, Prajda N. Adv Enz Reg. 34:71-89 (1994).

A4547 Alloxan Monohydrate 5 g2,4,5,6(1H,3H)-pyrimidinetetrone monohydrate 10 gC4H2N2O4 FW 160.08 [50-61-5] 25 gIt is a cytotoxic compound which causes oxidative base damage to nuclear and mtDNA. It also inhibits pancreatic cancer by selectively destroying pancreatic islet cells, and gall bladder cancer.Driggers WJ, Holmquist GP, LeDoux SP, Wilson GL. Nucleic Acids Res 25:4362-9 (1997).Pour PM. Frontiers in Bioscience 2:271-282 (1997).Pour PM, Donnelly K, Stepan K. Am J Pathology 110:310-4 (1983).

S-Allyl-L-cysteine (See L-Deoxyalliin)

A4544 Allyl Disulfide (See page 11 for more information) 500 mgC6H10S2 FW 146.28 [2179-57-9] d 1.008 1 gGarlic constituent. Known to have anticarcinogenic and antimicrobial activity. 5 g It inhibits human tumor cell proliferation, induces apoptosis in human colon tumor

cells, and selectively kills HIV-1-infected cells.Reddy S, Rao CV, Rivenson A, Kelloff G. Cancer Res. 35:3493-8 (1993).

Sundaran SG, Milner JA. Biochim Biophys Acta. 1315:15-20 (1996).

Sundaran SG, Milner JA. Carcinogenesis. 17:669-73 (1996).

Shoji S, Furuishi K, Yanase R et al. Biochem Biophys Res Commun. 194:610-21 (1993).

A4577 Alsterpaullone 1 mgC16H11N3O3 FW 293.28 [237430-03-4] 5 mgThe most active paullone. It is a potent inhibitor of glycogen synthase kinase-3β and cyclin-

dependent kinase 5/p25. It has been shown to induce apoptosis and promote loss in clonogenicity

in the Jurkate cell line.Leost M, Schultz C, Link A et al. European J Biochem. 267:5983-94 (2000).

Lahusen T, De Siervi A, Kunick C et al. Molecular Carcinogenesis. 36:183-94 (2003).

A4675 Alternariol 1 mgC14H10O5 FW 258.23 [641-38-3] 5 mgA mycotoxin that contaminates fruit and cereals. It has antifungal and phytotoxic activity and is a cholinesterase inhibitor.Davis VM, Stack ME. Appl. Enviorn. Microbiol. 10:3901-3902 (1994).

Brugger Em, Wagner J, Schumacher DM, et al. Toxicol. Lett. 164:221-230 (2006).

S S

S S

O

O

OH

OOH

HO


A4678 Alternariol-9-methyl ether 1 mgC15H12O5 FW 272.25 [23452-05-3] 5 mgIt is a mycotoxin that contaminates fruit and cereals. It has antifungal and

phytotoxic activity and is a cholinesterase inhibitor.

Davis VM, Stack ME. Appl. Enviorn. Microbiol. 10:3901-3902 (1994).

Brugger Em, Wagner J, Schumacher DM, et al. Toxicol. Lett. 164:221-230 (2006).

A4578 Altretamine 500 mgC9H18N6 FW 210.28 [645-05-6] 1 gAn antineoplastic agent. Active in ovarian cancer, lymphomas, bronchogenic 5 gcarcinoma, and carcinoma of the breast.

Lake LM, Grunden EE, Johnson BM. Cancer Res. 35:2858-63 (1975).

Legha SS, Slavik M, Carter SK. Cancer. 38:27-35 (1976).

A4496 Alyssin 25 mgC7H13NOS2 FW 191.32 [646-23-1] 50 mgHomolog of sulforaphane. 100 mg

500 mg

A4497 Alyssin sulfone, 97% 25 mgC7H13NO2S2 FW 207.31 50 mg

100 mg500 mg

A4498 Alytesin 1 mgC68H106N22O17S FW 1535.8 [31078-12-3] 2 mgA neuropeptide isolated from amphibian skin that stimulates gastric acid 5 mgsecretion, intestinal contraction and hypertension in dogs.

Anastasi et. al. Experientia. 27:166-7 (1971).

A4802 Amantadine Hydrochloride 25 gAdamantan-1-amine 100 gC10H17N.HCl FW 187.71 [665-66-7]An antiviral drug. Inhibits ion channels of influenza, and disrupts T-cell development.

Griffin SD, Beales LP, Clarke DS et al. FEBS Lett. 535:34-8 (2003).

Smith CA, Graham CM, Mathers K et al. Immunology. 105:306-13 (2002).

A4803 Amantadine Sulfate 25 g(C10H17N)2

.H2SO4 FW 400.58 [31377-23-8] 100 g It is a mycotoxin that contaminates fruit and cereals. It has antifungal and phytotoxic

activity and is a cholinesterase inhibitor.

A4805 Amastatin Hydrochloride 1 mgC21H38N4O8

.HCl FW 511.01 [100938-10-1] 5 mgAn inhibitor of aminopeptidase shown to prolong the effect of both vasopressin 10 mgand oxytocin.

Meisenberg G, Simmons WH. Peptides. 5:535-9 (1984).

Chen X, Pittman QJ. J Neurophysiol. 82:1689-96 (1999).

L-(+)-Amethopterin Dihydrate (See Methotrexate)

A4806 Ambroxol Hydrochloride 1 gC13H18Br2N2O.HCl FW 414.57 [23828-92-4] 5 g A metabolite of bromhexine that is a mucolytic agent. It prevents neutrophil- 25 gmediated A1AT inactivation via inhibition of HOCl production as well as HOCl

scavenging, in addition to inhibiting proinflammatory cytokines.

Su X, Wang L, Song Y et al. Intens Care Med. 30:133-40 (2004).

Ottonello L, Arduino N, Bertolotto M et al. Brit J Pharmacol. 140:736-42 (2003).

Sepulveda J, Velasquez BJ. Respiration. 43:363-88 (1982).

S N

C

S

O

pGlu-Gly-Arg-Leu-Gly-Thr-Gln-Trp-Ala-Val-Gly-His-leu-Met-NH2

O

OH

OOH

O


A4933 Amifostine 50 mgAminopropyl aminoethylthiophosphate 100 mgC5H15N2O3PS FW 214.22 [20537-88-6] 500 mgAmifostine is a chemoprotective drug used to selectively protect normal tissues from the of chemotherapeutic drugs such as cyclophosphamide, mitomycin-C and cisplatin, and ionizing radiation therapy.Culy CR, Spencer CM. Drugs 61:641-84 (2001).

Grdina DJ, Kataoka Y, Murley JS. Drug Metabol Drug Interact 16:237-79 (2000).

A5132 Amikacin Disulfate 250 mgC22H43N5O13

.2H2SO4 FW 781.76 [39831-55-5] 1 gAn aminoglycoside antibiotic derived from Kanamycin A. 5 gDanhauer FJ, Fortner CL, Schimpff SC et al. Clin Pharm. 1:539-43 (1982).

Guy H, Chavanet P, Portier H, et al. Nouv Presse Med. 10:654-6 (1981).

A5133 Amiloride HCl Dihydrate 500 mgC6H8ClN7O.HCl.2H2O FW 302.12 [17440-83-4] 1 gPotassium-sparing diuretic. 5 gBaer JE, Jones CB, Spitzer SA, Russo HF. J Pharmacol Exp Ther 157:472-85 (1967).

A4930 7-Amino-actinomycin D 1 mgC62H87N13O16 FW 1270.430 [7240-37-1] 5 mgA reagent used as a cytochemical probe. It forms complexes with DNA in solution resulting in shifts

of both the excitation and emission wavelengths. It has been used successfully to identify apoptosis.

Gill, J.E.; Jotz, M.M.; Young, S.G et al. J Histochem & Cytochem. 23:793-799 (1975).

Philpott, N.J., Turner, A.J., Scopes, J. et al. Blood 87:2244-2241 (1996).

A4931 3-Aminobenzamide 100 mgC7H8N2O FW 136.15 [3544-24-9] 250 mgA poly (ADP-ribose) Polymerase (PARP) inhibitor. A stress response protein 500 mgactivated by cytotoxic agents and makes cells resistant to apoptosis. It inhibits the

modification of specific sites in replicating DNA. It also stimulates repair replication

after exposure to alkylating agents.

Lee YJ, Shacter E. J Biol Chem. 274:19792-8 (1999).

Kurian P, Kumari HL, Milo GE. Carcinogenesis. 13:489-91 (1992).

Cleaver JE. Carcinogenesis. 17:1-3 (1996).

γ-Amino-n-butyric acid (See GABA)

A4935 6-Aminocaproic acid 10 gC6H13NO2 FW 131.17 [60-32-2] 100 gA protease inhibitor with chemopreventive properties. It inhibits chemically induced carcinogenesis

of the esophagus, peripheral nerve, brain and kidney in experimental animals.

Bespalov VG, Aleksandrov VA, Petrov AS, Troian DN. Vopr Onkol. 38(1):69-74. (1992).

Alexandrov VA, Bespalov VG, Petrov AS, Troyan DN, Lidaks MYu. Carcinogenesis. 17(9):1935-9 (1996).

A5032 D,L-Aminoglutethimide 500 mg3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione 1 gC13H16N2O2 FW 232.28 [125-84-8]An adrenocortical suppressant which also inhibits conversion of androgens to estrogens by the

aromatase enzyme system. Reduces tumor multiplicity and increases latent period of

MNU-induced mammary tumorigenesis.

Pelissero C, Lenczowski MJ, Chinzi D et al. J Steroid Biochem Mol Biol. 57:215-23 (1996).

Moon RC, Steele VE, Kelloff GJ et al. Anticancer Res. 14:889-93 (1994).

A4940 6-Aminonicotinamide 1 gC6H7N3O FW 137.14 [329-89-5] 5 gInduces apoptosis in tumor cells. Member of the drug combination called PMA which induces

regression of murine mammary tumors by depleting ATP.

Ogata S, Takeuchi M, Fujit, H et al. Biosci Biotechnol Biochem 64:327-332 (2000).

Nord, L.D., Stolfi, R.L., Alfieri, A.A., et al Cancer Chemother Pharmacol. 40:376-384 (1997).

Colofiore JR, Stolfi RL, Nord LD, Maartin DS. Biochem Pharmacol 50:1943-8 (1995).


A5001 Aminopterin 25 mg4-Aminofolic acid 100 mgC19H20N8O5 FW 440.41 [54-62-6] 500 mgAn inhibitor of dihydrofolate reductase shown to induce apoptosis in mouse

HGPRT(-) myeloma cell lines.

Chung YH, Youn J, Choi Y et al. Immunol Lett. 77:127-31 (2001).

Kremer P, Hartung G, Bauder-Wust U et al. Anticancer Drugs. 13:615-23 (2002).

A5030 4-Aminophenylphosphate monosodium salt, 98% 10 mgC6H7NO4PNa FW 211.09 [52331-30-3] 50 mgSubstrate for the electrochemical measurement of alkaline phosphatase. 100 mgFrew JE, Foulds NC, Wilshere JM, Forrow NJ, Green MJ. J. Electroanal. Chem., 266:309-316 (1989).

A5134 Aminophylline Anhydrous 25 gC16H24N10O4 FW 420.43 [317-34-0] 100 gThe water soluble complex of Theophyline. A non-selective phosphodiesterase 500 g inhibitor.

Noguchi Y, Ito M, Katsumi K et al. Gastroenterol Jpn. 21:129-34 (1986).

Reddy SV, Maderdrut JL, Yaksh TL. J Pharmacol Exp Ther. 213:525-33 (1980).

A5135 Aminophylline Dihydrate 25 gC16H24N10O4

.2H2O FW 456.47 100 gAminophylline is used to treat bronchial asthma. 500 g

A5033 4-Aminosalicylic acid 25 gp-Aminosalicylic acid 100 gC7H7NO3 FW 153.14 [65-49-6] 500 gAn antituberculous agent. Effective in treatment of distal ulcerative colits.

Oda N, Matsumoto K. Yakushigaku Zasshi 36:161-6 (2001).

O'Donnell LJ, Arvind AS, Hoang P et al. Gut. 33:947-9 (1992).

A5034 4-Aminosalicylic acid sodium dihydrate 25 gp-Aminosalicylic acid sodium salt 100 gC7H6NNaO3

.2H2O FW 211.15 [6018-19-5] 500 gSodium salt of p-Aminosalicylic acid.

A5035 5-Aminosalicylic acid 25 gMesalazine; mesalamine 100 gC7H7NO3 FW 153.14 [89-57-6]The active metabolite of Sulphasalazine. Effective in remission of Crohn's disease.

Rhodes JM, Bartholomew TC, Jewell DP. Glut. 22:642-7 (1981)

Modigliani R, Colombel JF, Dupas JL et al. Gastroenterology 110:688-93 (1996).

A5037 Amiodarone Hydrochloride 1 gC25H29I2NO3

.HCl FW 681.78 [19774-82-4] 5 gBenzofuran derivative with multiple electrophysiological effects. 10 gInduces apoptosis in human and rat alveolar epithelial cells in vitro.

Bargout R, Jankov A, Dincer E et al. Am J Physiol Lung Cell Mol Physiol. 27:1039-44 (2000).

Abdul M, Hoosein N. Cancer Lett. 186:99-105 (2002).

A5234 Amisulpride 25 mgC17H27N3O4S FW 369.48 [71675-85-9] 100 mgEnhances dopaminergic neurotransmission by preferentially blocking D2/D3 500 mgautoreceptors. A second generation antipsychotic.

Rettenbacher M. Journal of psychopharmacology (2007), 21(4), 400-4.

Strasser O. Psychiatrische Praxis (2004), 31 Suppl 1 S38-40.

Curran M P Drugs (2001), 61(14), 2123-50.

N

N

N

N NH2

NH2

HN

HN

O

COOH

COOH


A5039 Amitraz 5 gC19H23N3 FW 293.41 [33089-61-1] 25 gFormamidine pesticide with carcinogenic potential. It has been shown that 100 gamitraz-induced mydriasis is mediated by postsynaptic alpha 2-adrenoreceptors while

amitraz-induced bradycardia is mediated by presynaptic alpha 2-adrenoreceptors.

Moser VC, MacPhail RC. Toxicol Lett. 28:99-104 (1985).

Hsu WH, Kakuk TJ. Toxicol Appl Pharmacol 73:411-5 (1984).

A5235 Amitriptyline Hydrochloride 10 gC20H23N.HCl FW 313.86 [549-18-8] 25 gA tricyclic anti-depressant. Inhibits uptake of serotonin and noradrenaline 100 g equally.

Altintoprak, A. Human Psychopharmacology (2008), 23(4), 313-319

Sawynok, J. Neuroscience Letters (2008), 440(2), 181-184.

A4944 Amlexanox 500 mgC16H14N2O4 FW 298.29 [68302-57-8] 1 gMedication with antiallergic and anti-inflammatory effects used in the 5 gtreatment of aphthous ulcers.

Rani SG, Mohan SK, Yu C. Biochemistry. 49(11):2585-92 (2010).

A5045 Amlodipine 1 gC20H25ClN2O5 FW 408.88 [88150-42-9] 5 gA calcium channel antagonist with potent antioxidant activity. It inhibits 10 gdoxorubicin-induced myocyte apoptosis by supressing the mitochondrial apoptotic pathway. It has been found to inhibit hyperplasia and hypertrophy in mesangial cells.Yamanka S, Tatsumi T, Shiraishi J et al. J Am Coll Cardiol. 41:870-8 (2003).

Shultz PJ, Raij L. Am J Hypertens. 5:912-4 (1992).

A5044 Amlodipine besylate 1 gC20H25ClN2O5

.C6H5SO3H FW 567.06 [111470-99-6] 5 gA calcium channel blocker commonly used in the treatment of hypertension and 10 gangina. It also has shown antireproductive effects in male rats: a reduction in sperm density, the amount of mature spermatids, and the number of Sertoli cells.Almeida SA, Teofilo JM, Anselmo JA et al. Exp Toxicol Pathol. 52:353-6 (2000).

A5056 Amorolfine Hydrochloride 100 mgC21H35NO.HCl FW 353.97 [78613-38-4] 250 mgA morpholine antimycotic agent. Interferes with ergosterol biosynthesis. 1 gHiratani, T. Asaqu Y. Matsusaka, A et al. Jpn. J. Antibiot. 44:993-1006 (1991).

Polak A. Dermatology 184Suppl1:3-7 (1992).

A5059 Amoxapine 250 mgC17H16ClN3O FW 313.78 [14028-44-5] 1 gTricyclic antidepressant. In animals it inhibits the reuptake of norepinephrine 5 g and to a lesser degree serotonin.

Chaudhry, I. J. of Clinical Psychopharmacology (2007), 27(6), 575-581.

Keck, T. J. Neuroscience (2008), 28(29), 7359-7369.

A5057 Amoxicillin 5 gC16H19N3O5S FW 365.41 [26787-78-0] 25 gA semi-synthetic antibiotic similar to penicillin. 100 gKochi T, Tachimori Y, Itoh N et al. Jpn J Antibiot. 34:1395-400 (1981).

Brogeden RN, Speight TM, Avery GS. Drugs. 9:88-140 (1975).

A5130 Amphotericin B 100 mgC47H73NO17 FW 924.08 [1397-89-3] 250 mgA polyene antibiotic produced by Streptomycetes nodosus that has shown 500 mgantitumor activity. 1 gPresant CA, Metter GE, Multhauf P et al. Cancer Treat Rep. 68:651-4 (1984).

Medoff J, Medoff G, Goldstein MN et al. Cancer Res. 35:2548-52 (1975).

O N

O

OH

O

NH2


A5160 Ampicillin Trihydrate 5 gC16H19N3O4S.3H2O FW 403.47 [7177-48-2] 25 gAn antibiotic. Semi-synthetic penicillin. 100 gVisuri T, Antila P, Laurent LE. Ann Chir Gynaecol Suppl. 65:58-61 (1976).

A5161 Ampiroxicam 1 gC20H21N3O7S FW 447.46 [99464-64-9] 5 gA prodrug of piroxicam with reduced gastrointestinal irritation. It is a non- 25 gsteroidal anti-inflammatory agent proven to be an effective chemopreventive agent.Olkkola KT, Brunetto AV, Mattila MJ. Clin Pharmacokinet. 26:107-20 (1994).

Carty TJ, Marfat A, Moore PF et al. Agents Actions. 39:157-65 (1993).

A5162 Amprolium Hydrochloride 25 gC14H19ClN4

.HCl FW 315.25 [137-88-2] 100 gA coccidiostat mainly used in poultry feed. It inhibits the sporulation of the oocysts

of several common strains of coccidia.

Joyner, LP., Norton, CC. Parasitology 75:155-164 (1977).

A5170 Amrinone 250 mgC10H9N3O FW 187.20 [6071984-8] 1 gSelective phosphodiesterase III inhibitor. A nonglycoside, noncatecholamine agent

with positive inotropic effect. Inhibits cyclic AMP-dependent protein kinase activity

by competing with ATP but not cyclic AMP binding sites. It also inhibits platelet

aggregation and induces disaggregation.

Ono S, Ueda S, Sakuma T et al. J Cardiov. Surgery 37:177-81 (1996).

Earl CQ, Linden J, Weglicki WB. Life Sciences 39:1901-8 (1986).

Kikura M, Kazama T, Ikeda T et al. Platelets 11:446-58 (2000).

A5072 Amsacrine 10 mgC21H19N3O3S FW 393.46 [51264-14-3] 50 mgAn antineoplastic agent. Inibits topoisomerase II.

Genetic Response to Metals. Sarkar, Bibudhendra. CRC Press, (1995).

A5193 Amygdalin 1 gC20H27NO11 FW 457.43 [29883-15-6] 5 gA benzylic glycoside that has been used as an antineoplastic agent. 25 gFukuda T, Ito H, Makainaka et al. Biol Pharm Bull. 26:271-273 (2003).

Stock CC, Martin DS, Sugiura K et al. J Surgical Oncology. 10:89-123 (1978).

A4844 Amylin (8-37), human 0.5 mgC138H215N41O46 FW 3184.5 1 mgPutative polypeptide hormone from type 2 human diabetes and adult diabetic 2.5 mgcats which consists of 37-amino acid peptide subunit of amyloid. Edwards, B. J.; Morley, J. E. Life Sci. 51:1899-1912 (1992).

A4845 Amylin (8-37), rat 0.5 mgC140H227N43O43 FW 3200.63 1 mg

2.5 mg

A4846 Amylin (IAPP)(Feline) 0.5 mgC165H270N52O54S2 FW 3910.45 1 mg

2.5 mg

A4847 Amylin, human 0.5 mgC165H261N51O55S2 FW 3903.4 [122384-88-7] 1 mgA member of the calcitonin family of hormones that is co-secreted with insulin 2.5 mg from the pancreas during and after food intake. It inhibits RINm5F islet beta-cell proliferation and evokes apoptosis associated with typical degenerative ultrastructural changes and DNA fragmentation.Zhang S, Liu J, Saafi EL et al. FEBS Lett. 455:315-20 (1999).

Riediger T, Zuend D, Becskei C et al. Am J Physiol Regul Integr Comp Physiol. 286:R114-22 (2004).

N

SNH

O

CH3

CH3

COOH

HH

O

NH2

H-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Arg-Ser-Ser-Asn-Asn-Leu-Gly-Pro-Val-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2

H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Ile-Arg-Ser-Ser-Asn-Asn- Leu-Gly-Ala-Ile-Leu-Ser-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide Bridge Cys2-Cys7)

H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-lle-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2

H-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-OH

N

HN

MeO HNS

O

O


A4850 Amylin, rat 0.5 mgC167H270N52O53S2 FW 3918.47 1 mg

2.5 mg

A4851 β-Amyloid (1-40), rat 0.5 mgC190H291N51O57S1 FW4233.81 [131438-79-4] 1 mgA protein that stimulates the release of nitric oxide in neuronal cell lines. It often 2.5 mgforms the neurotoxic peptide deposits associated with Alzheimer's disease and aging.Hu J, el-Fakahany EE. Neuroreport. 4(6):760-762 (1993).

A4852 β-Amyloid (1-40), Ultra Pure, TFA 0.5 mgC194H295N53O58S1 FW4329.9 1 mg

2.5 mg

A4853 β−Amyloid (1-42), human 0.5 mgC203H311N55O60S1 FW 4550.18 1 mg

2.5 mg

A4849 β-Amyloid (25-35) 1 mgC45H81N13O14S1 FW 1060.27 [131602-53-4] 2 mgThe 11-residue functional domain of Amyloid-β protein. 5 mg

A4854 β-Amyloid Peptide (1-42), rat 1 mgC199H307N53O59S1 FW 4454.09 [107761-42-2] 2 mg

5 mg

A4848 Amyloid-β Protein (1-40) 1 mgC194H295N53O58S Mol Wt: 4329.8 [131438-79-4]A protein that stimulates the release of nitric oxide in neuronal cell lines. It often forms the neurotoxic peptide deposits associated with Alzheimer's disease and aging.Hu J, el-Fakahany EE. Neuroreport. 4(6):760-762 (1993).

A5202 Anabasine Hydrochloride 25 mgC10H14N2

.HCl FW 198.73 [15251-47-5] 100 mgAn anabisis aphylla alkaloid with antialcoholic effects. It has been shown to suppress breast cancer aromatase activity.Kadohama N, Shintani K, Osawa Y. Cancer Lett. 75:175-82 (1993).

Mirzaez S. Farmakol Toksikol. 41:52-5 (1978).

A5327 Anagrelide 10 mgC10H7Cl2N3O FW 256.09 [68475-42-3] 25 mgPhosphodiesterase inhibitor. Inhibits maturation of megakaryocytes into platelets. 100 mgWilmes LJ. Magn Reson Imaging 25(3):319-27

Rugo HS. J Clin Oncol. 23(24):5474-83

A5302 Anastrozole 100 mgC17H19N5 FW 293.37 [120511-73-1] 250 mgA selective aromatase inhitor used to treat hormone-responsive metastic 1 gbreast cancer. It may be effective against recurrent ovarian adult granluosa cell tumors.Plourde, PV., Dyroff, M., Dowsett, M. et al. J. Steroid Biochem. Mol. Biol 53:175-179 (1995).

Freeman, SA., Modesitt, SC. Gynecol Oncol. 103:755-758 (2006).

A5313 Andrographolide 1 mgC20H30O5 FW 350.45 [5508-58-7] m.p. 218-2210C (dec.) 5 mgAndrographolide is from Andrographis paniculata. It inhibits PAP-induced 10 mghuman blood platelet aggregation, inhibits nitrite synthesis in macrophage,

and restores vasocontractile response in thoracic aorta.

Amroyan E, Gabrielian E, Panossian A et al. Phytomedicine 6:27-31 (1999).

Chiou WF, Lin JJ, Chen CF. Br. J. Pharmacol. 125:327-334 (1998).

H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Leu-Gly-Pro-Val-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2(Disulfide Bridge Cys2-Cys7)

H-Asp-Ala-Glu-Phe-Arg-His-Asp-

Ser-Gly-Tyr-Glu-Val-His-His-Gln-

Lys-leu-Val-Phe-Phe-Ala-Glu-

Asp-Val-Gly-Ser-Asn-Lys-Gly-

Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-

Gly-Val-Val-OH

H-Asp-Ala-Glu-Phe-Arg-His-Asp-

Ser-Gly-Tyr-Glu-Val-His-His-Gln-

Lys-leu-Val-Phe-Phe-Ala-Glu-

Asp-Val-Gly-Ser-Asn-Lys-Gly-

Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-

Gly-Val-Val-Ile-Ala-OH

Gly-Ser-Asn-Lys-Gly-Ala-lle-lle-Gly-Leu-Met

H-Asp-Ala-Glu-Phe-Gly-His-Asp-

Ser-Gly-Phe-Glu-Val-Arg-His-Gln-

Lys-Leu-Val-Gly-Phe-Phe-Ala-

Glu-Asp-Val-Gly-Ser-Asn-Lys-

Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-

Gly-Gly-Val-Val-Ile-Ala-OH

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-lle-lle-Gly-Leu-Met-Val-Gly-Gly-Val-Val

N

N

NH

Cl

Cl

O

H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Gly-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH


A5314 Andrographolide, dehydro- 1 mgC20H28O4 FW 332.43 5 mgA natural product used for anti-inflammatory purposes. 10 mg

A5315 Andrographolide, deoxy- 1 mgC20H30O4 FW 334.45 5 mgAnti-inflammatory drug isolated from Andrographis paniculata Nees. A potent 10 mg cell differentiation-inducer of M1 cells.

Shen YC, Chen CF, Chiou WF. Planta Med. 66:314-7 (2000).

Matsuda T, Kuroyanagi M, Sugiyama S et al. Chem Pharm Bull 42:1216-25 (1994).

A5217 trans-Anethole 50 mlp-Propenylanisole 100 mlC10H12O FW 148.20 m.p. 230C [4180-23-8]Induces Phase II drug-metabolizing enzymes. A potential

anti-carcinogen in Ehrlich ascites tumor cells.

Rompelberg CJ, Verhagen H, van Bladeren PJ. Food Chem Toxicol., 31:637-645 (1993).

al-Harbi MM, Qureshi S, Raza M et al. Eur J Cancer Res. 4:307-318 (1995).

A5219 Anethole-trithione 25 mgC10H8OS3 FW 240.37 [532-11-6] 100 mgAnalogue of the chemopreventive agent oltipraz. It was shown to increase 500 mgcholinergic and adrenergic responsiveness in rats. Mechanism may act by

stimulating some post-receptor effect in the coupling to the secretory response.Lubet RA, Steele VE, Eto I et al. Int J Cancer. 72:95-101 (1997).

Glenert U. Eur J Pharmacol. 226:43-52 (1992).

A5225 α-ANF(1-28), human 0.5 mgC127H203N45O39S3 FW 3080.46 [91917-63-4] 1 mgThe major form of atrial natriuretic peptide in circulation throughout the body. 2.5 mgModulates saline and fluid balance in the blood by stimulating renin release.

Hisa H, Tomura Y, Satoh S. Am J Physiol. 257(3 Pt 1):E332-335 (1989).

A5228 Angiogenin 50 µgMol. Wt. ~14,000 Da [91917-63-4]An endogenous single chain protein that induces the formation of blood vessels.

Fett JW. Biochemistry 24:5480 (1985).

Shapiro R. Biochemistry 26:5141 (1987).

A5230 Angiostatin 0.5 mg [86090-08-6]A 38-kD fragment of plasminogen that is a potent endothelial cell growth inhibitor.

It has been shown to inhibit angiogenesis in vivo and tumor growth in mice.O'Reilly MS, Holmgren L, Chen C et al. Cell. 79:315-28 (1994).

Scappaticci FA, Smith R, Pathak A et al. Molecular Therapy. 3:186-96 (2001).

A5070 Angiotensin Acetate Please inquireC49H69N13O12 FW 1032.18

A5272 Angiotensin, Canine, rat 5 mgC41H62N12O11 FW 899.03 10 mg

25 mg

A5273 Angiotensin Converting Enzyme Inhibitor 5 mgC53H77N14O12 FW 1102.29 10 mg

25 mg

A5275 Angiotensin I [Des-Asp1-], human 5 mgC58H84N16O11 FW 1181.42 10 mg

25 mg

Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-lle-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr(Disulfide bridge Cys7-Cys23)

Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-lle-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr(Disulfide bridge Cys7-Cys23)

Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH

H-Asp-Arg-Val-Tyr-Ile-His-Pro-

Phe-His-Leu-OH

H-pGlu-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-OH

H-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-OH


A5276 Angiotensin I, human 5 mg C62H89N17O14 Mol Wt: 1296.49 [70937-97-2] 10 mgThe decapeptide precursor to angiotensin II. 25 mg

A5277 Angiotensin II, human 5 mgC50H71N13O12 FW 1046.19 [68521-88-0] 10 mgA vasoactive agent that acts on the adrenal gland to stimulate the release of 25 mgaldosterone.Wallace KB, Roth RA, Hook JB et al. Am J Physiol. 238:R395-399 (1980).

A5279 Angiotensin II (1-4), human 5 mgH-Asp-Arg-Val-Tyr-OH C24H37N7O8 FW 551.6 10 mg

25 mg

A5280 Angiotensin II (3-8), human 5 mgC40H54N8O8 FW 774.93 [23025-68-5] 10 mg

25 mg

A5281 Angiotensin II (4-8), human 5 mgC35H45N7O7 FW 675.79 10 mg

25 mg

A5282 Angiotensin II [Sar1 Ile8] 5 mgC46H74N13O10 FW 968.1 [67724-27-0] 10 mg

25 mg

A5283 Angiotensin II [Sar1] 5 mgC49H71N13O11 FW 1018.19 10 mg

25 mg

A5284 Angiotensin II, human [Val5] 5 mgC49H69N13O12 FW 1032.18 10 mg

25 mg

A5278 Angiotensin III, human 5 mgC46H66N12O9 FW 931.1 [12687-51-3] 10 mgThe amino-terminal degradation product of AngII. It is a central regulator of 25 mg vasopressin release and blood pressure. It has been found to activate NF-kappaB

and AP-1 and to increase MCP-1 in mesangial and mononuclear cells.

Reaux A, Fournie-Zaluski MC, Llorens-Cortes C. Trends Endocrinol Metab. 12:157-62 (2001).

Ruiz-Ortega M, Lorenzo O, Egido J. Kidney Int. 57:2285-98 (2000).

A5285 [Ile7] Angiotensin III 1 mgC43H68N12O9 FW 897.1 2 mg

5 mg

A5287 Angiotensinogen (1-14), human 1 mgC83H122N24O19 FW 1760.05 2 mgA precursor of Angiotensin I. Angiotensinogen is cleaved by renin as a response 5 mg to lowered blood pressure.

Ohkubo H,Kageyama R,Ujihara M,Hirose T,Inayama S,Nakanishi S.ProcNatlAcadSciUSA.80:2196-200(1983).

A5326 Aniracetam (See page 18 for more information) 100 mgC12H13NO3 FW 219.24 [72432-10-1] 500 mgCognition enhancer that potentiates AMPA receptor mediated ion conductance. 1 gIt slows the rate of channel closing and the microscopic rates of desensitization.

Antiapoptotic effects have been confirmed by the increase of intracellular ATP and phosphocreatine levels.

Lawrence JJ, Brenowitz S, Trussell LO. Mol Pharmacol. 64:269-78 (2003).

Gabryel B, Adamczyk J, Huzarska M et al. Neurotoxicology. 23:385-95 (2002).

Asp-Arg-Val-Tyr-lle-His-Pro-Phe-His-Leu

H-Sar-Arg-Val-Tyr-Ile-His-Pro-Phe-OH

Arg-Val-Tyr-lle-His-Pro-Phe

H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH

H-Asp-Arg-Val-Tyr-OH

H-Val-Tyr-Ile-His-Pro-Phe-OH

H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH

H-Sar-Arg-Val-Tyr-Ile-His-Pro-Ile-OH

H-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH

H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH


A5334 Anisodamine (See page 21 for more information) 100 mgC17H23NO4 FW 305.37 [55869-99-3] 500 mgHas an inhibitory effect on acetylcholine receptor channels. Found to inhibit 1 gShiga toxin-1-induced cytokine production, significantly decreasing lethality.

Zhang HM, Ou ZL, Gondaira F et al. J Lab Clin Med. 137:93-100 (2001).

Guo H, Lorenz RR, Vanhouette PM. Chin Med Sci J. 7:32-35 (1992).

A5373 Anisomycin 5 mgFlagecidin 25 mgC14H19NO4 FW 265.31 [22862-76-6] 100 mgA protein synthesis inhibitor as well as an activator of p38 MAP kinase and

c-Jun N-terminal kinases. Causes apoptosis of PC12 cells.Torocsik B, Szeberenyi J. Biochem Biophys Res Comm. 278:550-6 (2000).

Ogawa T, Hayashi T, Kyoizumi S et al. Journal of Cell Science. 117:2087-96 (2004).

A5458 Anorexigenic Peptide 1 mgpGlu-His-Gly-OH C13H17N5O5 FW 323.4 [69275-10-1] 2 mg

An appetite suppressing peptide isolated from urine of anorexia nervosa patients. 5 mgCoy et. al. J Physiol 341:225-235 (1981).

A5460 ANP (1-11), rat 1 mgC49H83N20O15S1 FW 1224.4 2 mgA potent natriuretic and vasodilatory peptide secreted by the heart atria. 5 mgHirsch JR, Meyer M, Forssmann WG. Eur J Med Res. 27:447-54 (2006).

A5461 ANP (1-30), frog 0.5 mgC131H215N49O41S4 FW 3260.73 1 mg

2.5 mg

A5476 Antagonist G 0.5 mgC49H62O6N12S FW 951.2 [115150-59-9] 1 mgAn anticancer peptide with a broad spectrum neuropeptide growth factor antagonist. 2.5 mgJones, D.A.; Cummings, J.; Langdon, S. P.; Smyth, J. F. Gen Pharmacol. 28:183-9 (1997).

A5477 Antide Acetate Please inquireC82H108ClN17O14 FW 1591.32 [112568-12-4]

A5479 Antiestrogen 0.5 mgC64H103N13O22SP FW 1469.64 1 mg

2.5 mg

A5378 Antimycin A 10 mgC28H40N2O9 FW 548.63 [1397-94-0] 50 mgAn inhibitor of mitochondrial respiratory chain complex III. Induces apoptosis in cell cultures.

Formigli L, Papucci L, Tani A et al. J. Cell Physiol. 182:41-9 (2000).

Mills KI, Woodgate LJ, Gilkes AF et al. Biochem Biophys Res Commun. 263:294-300 (1999).

A5478 Antipain Dihydrochloride 1 mgC27H44N10O6

. 2HCl F.W: 677.62 [37691-11-5] 5 mgA natural protease inhibitor and known inhibitor of carcinogenesis induced by 25 mg the S-phase dependent alkylating agent N-methyl-N-nitro-N-nitroso guanidine. It

has been shown to supress chromosomal aberrations in human lymphocytes and reduce

nuclear binding of estrogen-receptor complex in MCF-7 breast tumor cells.Afzal V, Wiencke JK, Wolff S. Carcinogenesis. 10:1193-6 (1989).

Umans RS, Weichselbaum RR, Johnson CM, Kennedy AR. Carcinogenesis. 5:1355-7 (1984).

A6002 Apamin 0.5 mgC79H131N31O24S4 FW 2027.37 1 mgA potent neurotoxic peptide isolated in honeybee venom, blocks calcium- 2.5 mgactivated potassium channels. Apamin is know to cause thermal and mechanical hypersensitivity in rats.Chen YN, et. al. Neuroscience. 138: 631-40 (2006).

H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-OH

H-Ala-Pro-Arg-Ser-Met-Arg-Arg-Ser-Ser-Asp-Cys-Phe-Gly-Ser-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Met-Gly-Cys-Gly-Arg-Phe-OH(Disulfide Bridge Cys11-Cys27)

H-Arg-D-Trp-N-Me-Phe-D-Trp-Leu-Met-NH2

Ac-D-2-Nal-p-Chloro-D-Phe-b-(3-pyridyl)-D-Ala-Ser-Lys (nicot inoyl)-D-Lys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-D-Ala-NH2

H-Cys-Asn-Val-Val-Pro-Leu-Tyr (PO3H2)-Asp-Leu-Leu-Leu-Glu-OH

H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2(Cys1-Cys11, Cys3-Cys15)


A6017 Apelin-13, human, bovine 0.5 mgC69H111N23O16S FW 1550.86 1 mgAn endogenous ligand for the G protein-coupled receptor. 2.5 mgLee D.K. et. al.J Neurochem. 74: 34-41 (2000).

A6229 Aphidicolin 1 mgC20H34O4 FW 338.48 [38966-21-1] 5 mgDNA polymerase inhibitor. Potentiates apoptosis induced by therapeutic 10 mgnucleosides.

Kuwakado K, Kubota M, Hirota H et al. Biochem Pharmacol. 46:1909-16 (1993).

Lin CK, Nguyen TT, Morgan TL et al. Exp Cell Res. 244:1-13 (1998).

A6132 Apicidin 1 mgC34H49N5O6 FW 623.78 [183506-66-3] 5 mgIs a fungal metabolite with anti-parastitic activity effected by inhibiting histone

deactylase. Shows a broad spectrum or antiproliferative activity against various cancer cells.

Mazitschek, R. Bioorganic & Medicinal Chemistry Letters (2008), 18(9), 2809-2812

Wang, J. Journal of Biological Chemistry (2007), 282(39), 28408-28418.

Ueda, T. International Journal of Molecular Medicine (2007), 19(2), 301-308.

A6234 Apigenin 5 mgC15H10O5 FW 270.24 [520-36-5] 25 mgA nonmutagenic flavonoid, shown to inhibit cell proliferation, angiogenesis, 100 mgand protein kinase. It also induces apoptosis in breast cancer cells via the

phosphatidylinositol 3-kinase/Akt-dependent pathway.

Way TD, Kao MC, Lin JK. J Biol Chem. 279:4479-89 (2004).

Osada M, Imaoka S, Funae Y. FEBS Letters. 575:59-63 (2004).

A6264 Apramycin Sulfate 1 gC21H41N5O11 .H2O4S FW 637.66 [65710-07-8] or [41194-16-5] 5 gAminoglycoside antibiotic shown to be a potent inhibitor of protein synthesis in bacteria in vivo and in vitro. It works by inhibiting the translocation step of protein synthesis. Perzynski S, Cannon M, Cundliffe E et al. Eur J Biochem. 99:623-8 (1979).Davies J, O'Connor S. Antimicrob Agents Chemother. 14:69-72 (1978).

A6368 Aprepitant 5 mgC23H21F7N4O3 FW 534.43 [170729-80-3] 10 mgAn antiemetic chemical compound that belongs to a class of drugs called 25 mgsubstance P antagonists (SPA). It mediates its effect by blocking the neurokinin 1 (NK1) receptor.Gralla RJ, de Wit R, Herrstedt J, et al. Cancer 104:864-868 (2005).

A6268 Aprotinin 10 mgC284H432N84O79S7 FW 6511.83 [9087-70-1] 50 mgA pancreatic basic trypsin inhibitor polypeptide found in tissues and blood.Haberland G, McConn R. Fed Proc. 38:2760-67 (1979).

A6804 Arbutin 5 gC12H16O7 FW 272.25 [497-76-7] 10 gAntibacterial agent from traditional medicinal plants. It is present in the leaves 25 gof bearberry, blueberry, cranberry and pear. It was found to have depigmenting

action in human melanocytes in culture. It inhibits tyrosinase activity.Maeda K, Fukuda M. J Pharmacol Exp. Ther. 276:765-9 (1996).Jin YH, Lee SJ, Chung MH et al. Arch Pharm Res 22:232-6 (1999).

A6922 Arformoterol tartrate 5 mgC19H24N2O4 FW 344.4 [200815-49-2] 10 mgLong acting beta-adrenoceptor agonist. Used in the treatment of chronic 25 mgobstructive pulmonary disease.Bonasia, P. Current Medical Research and Opinion (2007), 23(10), 2477-2483.

A6823 Argatroban 10 mgC23H36N6O5S FW 508.64 [74863-84-6] 25 mgA thrombin inhibitor that prevents tumor cell migration and bone metastasis. 100 mg It has been shown to be more effective than heparin in preventing platelet loss and expression of P-selectin.Kanemitsu S, Nishikawa M, Onoda K et al. J Thorac Cardiov Sur. 126:428-35 (2003).Asanuma K, Wakabayashi H, Hayashi T et al. Oncology. 67:166-73 (2004).

MeO

NH

H

OH

OHHN

H

O

H-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH

F

N

O

O

F F

F

F

FF

NH

NH

N

O


A6825 L-Arginine 25 gC6H14N4O2 FW 174.20 [74-79-3] 100 gPlays a role in nitric oxide synthesis that induces vasodilation in vivo. Nitric 500 g oxide potentiates insulin-mediated glucose uptake through the increase in blood flow.

Dallinger S, Sieder A, Strametz J et al. Am J Physiol Endocrinol Metab. 284:E1106-11 (2003).

Paolisso G, Tagliamonte MR, Marfella R et al. Metabolism 46:1068-73 (1997).

A6826 L-Arginine Monohydrochloride 25 gC6H14N4O2

.HCl FW 210.66 [1119-34-2] 100 g500 g

A6828 Nα,Nα-Dimethyl-L-Arginine, Ammonium Salt 10 mgC8H18N4O2

.NH3 FW 219.28 25 mgNitric oxide inhibitor in vitro and in vivo. 100 mgKotani K et. Al. J. Neurochem. 58:1127 (1992).

A6829 NG,N'G-Dimethyl-L-Arginine, Ammonium Salt 10 mgC8H18N4O2

.NH3 FW 219.28 25 mg100 mg

A6827 Argpressin Acetate Please inquireC46H65N15O12S2 FW 1084.23 [113-79-1]

A7034 Aripiprazole 100 mg C23H27Cl2N3O2 FW 448.39 [129722-12-9] 250 mgUsed for the treatment of schizophrenia. Used for the treatment of acute manic 1 g and mixed episodes associated with bipolar disorder, and as an adjunct for the

treatment of depression.

Lawler CP et al. (1999). Neuropsychopharmacology 20 (6): 612–27.

A6932 Aristolochic acid A 1 mgC17H11NO7 FW 341.27 [313-67-7] m.p. 287-292oC 9dec) 5 mgAristolochic acids are the active ingredients responsible for the hepatoxicity 10 mgand renal toxicity of the Oriental herb Aristolochic fangchi. They form DNA adducts in renal tissue and are associated with urothelial carcinoma formation.

They are known to induce hepatic nodules and forestomach tumors in rats.

Levi M, Guchelaar HJ, Woerdenbag HJ, Zhu YP. Pharm. World Sci. 20:43-4 (1998).

Mengs U, Stotzem CD. Arch. Tox. 67:307-11 (1993).

Schmeiser HH, Bieler CA, Wiessler M et al. Cancer Res. 56:2025-28(1996).

A6933 Aristolochic Acid B 1 mgC16H9NO6 FW 311.25 5 mgSee Aristolochic Acid A 10 mg

A6934 Aristolochic acid C 1 mgC16H9NO7 FW 327.25 [4849-90-5] 5 mgSee Aristolochic acid A 10 mg

A6970 Artemether 50 mgC16H26O5 FW 298.37 [71963-77-4] 100 mgIt is an oil-soluble derivative of the antimalarial agent artemesinin. 500 mgZhao YH, Wang JY. Chinese Journal of Parasitology & Parasitic Diseases. 21:326-9 (2003). 1 gWhite NJ, Waller D, Crawley J et al. Lancet. 339:317-21 (1992).

Xiao SH, Catto BA. Antimicrob Agents Chemother. 33:1557-62 (1989).

H2N NH

OH

NH O

NH2

C[Cys-Tyr-Phe-Gln-Asn-Cys]Pro-Arg-Gly-NH2

NH

O

N N

O

Cl Cl


A6978 Artemisinin 100 mg Qinghaosu, arteanuin 500 mgC15H22O5 FW 282.35 M.P. 156-157OC [63968-64-9] 1 gNatural product isolated from the traditional Chinese antimalarial herb

Atremisia annua L. Cytotoxic against several tumor cell lines,

including Ehrlich ascites carcinoma cells.Qinghaosu Antimalaria Coordinating Research Group. Chinese Med J. 92:811-816 (1979).

Zheng GQ. Planta Med. 60:54-57 (1994).

Beekman AC, Woerdenbag HJ, Van Uden W et al. J Pharm Pharmacol. 49:1254-1258 (1997).

A6979 Dihydro-artemisinin 50 mgC15H24O5 FW 284.35 [71939-50-9] 100 mgA more water-soluble analogue of artemisinin. It inhibits tumor cell 500 mggrowth and suppresses angiogenesis in vitro. It has been shown 1 gto reduce VEGF binding to its receptors on the surface of HUVEC.Chen HH, Zhou HJ, Fang X. Pharmacological Research. 48:231-6 (2003).

Wu GD, Wang WQ, Zhou HJ et al. Cancer Chemotherapy & Pharmacology. 53:423-32 (2004).

A6982 Artesunate 50 mgC19H28O8 FW 384.42 [88495-63-0] 100 mgA semi-synthetic derivative of artemisinin that is used as an anti-malarial drug. 500 mgIt has been shown to inhibit angiogenesis in vivo and in vitro. 1 gChen HH, Zhou HJ, Wu GD et al. Pharmacology. 71:1-9 (2004).Zhao Y, Hanton WK, Lee KH. Journal of Natural Products. 49:139-42 (1986).

A7085 Arvanil 5 mgC28H41NO3 FW 439.63 [128007-31-8]A capsaicin-anandamide hybrid molecule that is a CB1/VR1 agonist. It has been shownto induce apoptosis through a FADD/caspase-8-dependent pathway, in addition toexerting a potent analgesic effect.Brooks JW, Pryce G, Bisogno T et al. Euro J Pharmacol. 439:83-92 (2002).

Sancho R, de la Vega L, Appendino G et al. Brit J Phamacol. 140:1035-44 (2003).

A7208 Ascomycin 1 mgC43H69NO12 FW 792.01 [104987-12-4] 5 mgAscomycin is an antifungal antibiotic. Its anticonvulsant effect is the result of inhibition of calcineurin activity which is involved in picrotoxin-induced epileptic seizures.Arai, T., Kouama, Y., Suenaga, T., Hoda, H. J. Antibiot. 15:231-232 (1962).

Vazquez-Lopez, A. Sierra-Paredes, ,G., Sierra-Marcuno, G. Pharmacol Biochem Behav. 84:511-516 (2006).

A7210 L(+)-Ascorbic Acid 100 gVitamin C 500 gC6H8O6 FW 176.12 [50-81-7]An antioxidant. Vitamin C reduces DNA single strand breaks and 1-hydroxyethyl-POBN adductformation caused by ethanol. It has been shown to prevent oral carcinogenesis induced by dimethyl benzanthracene. Induces apoptosis in HL-60 cells.Navasumrit P, Ward TH, Doss NJ, O'connor PJ. Carcinogenesis. 21:93-9 (2000).

Sawant SS, kandarker SV. Oral Dis. 6:241-247 (2000).

Satoh K, Ida Y, Hosaka M et al. Anticancer Res. 18:4371-5 (1998).

A7309 Ascorbyl Palmitate / 6-Palmitoylascorbic acid 25 g6-Palmitoylascorbic acid 100 gC22H38O7 FW 414.53 m.p. 114-1160C [137-66-6] 500 gA lipophilic vitamin C analogue with greater stability than ascorbic acid and enhanced antioxidant activity. A potent chemopreventive agent against colon cancer.Rao CV, Rivenson A, Kelloff GJ et al. Anticancer Res. 15:1199-1204 (1995).

Liu XY, Guo FL, Wu LM et al. Chem Phys Lipids. 83:39-43 (1996).

Austria R, Semenzato A, Bettero A. J Pharm Biomed Anal. 15:795-801 (1997).

A7332 Asiatic Acid 100 mgC30H48O5 FW 488.70 [464-92-6] 500 mgAsiatic acid is the aglycone of asiaticoside isolated from the plant Centella asiaticacommonly used in wound healing.Maquart FX, Chastang F, Simeon A et al. Europ. J Derm. 9:289-296 (1999).

Shukla A, Rasik AM, Jain GK et al. J. Ethnopharmacol. 65:1-11 (1999).

Yoosook C, Bunyapraphatsara N, Boonyakiat Y, Kantasuk C. Phytomedicine 6:411-419 (2000).

Medda S, Das N, Mahato SB et al. Indian J Biochem Biophys. 32:147-151 (1995).

NH

O

OH

OCH3

CH3


A7333 Asiaticoside 1 mgC48H78O18 FW 959.12 [16830-15-2] m.p. 230-233oC 5 mgAsiaticoside is a triterpene glycoside from the plant Centella asiatica commonly 10 mg used in wound healing. This activity is a result of stimulation of collagen and glycosaminoglycan synthesis. This glycoside was also found to have activity against herpes simplex virus 1 and 2 and mycobacterium tuberculosis.

Maquart FX, Chastang F, Simeon A et al. Europ. J Derm. 9:289-296 (1999).

Shukla A, Rasik AM, Jain GK et al. J. Ethnopharmacol. 65:1-11 (1999).

Yoosook C, Bunyapraphatsara N, Boonyakiat Y, Kantasuk C. Phytomedicine 6:411-419 (2000).

Medda S, Das N, Mahato SB et al. Indian J Biochem Biophys. 32:147-151 (1995).

A7460 Asparaginase Please inquire[9015-68-3]An enzyme that catalyzes the hydrolysis of asparagine to aspartic acid.

Appel IM, van Kessel-Bakvis C, Stigter R, Pieters R (2007). Leukemia 21: 2377

A7462 Aspartame 1 gC14H18N2O5 FW 294.30 [22839-47-0] 5 gA dipeptide ester used as low-calorie artificial sweetener. In solution, it is 25 g160 times sweeter than sucrose.

Aspirin (See Acetylsalicylic acid)

A7578 Astragaloside IV 10 mgC41H68O14 FW 784.97 [83207-58-3] 25 mgAstragaloside IV is the primary pure saponin isolated from 100 mgAstragalus membranaceus, displays antifibrotic effects.

Liu H, Wei W, Sun WY, Li X. J Ethnopharmacol. 122(3):502-8 (2009).

A7618 Atenolol 1 gC14H22N2O3 FW 266.34 [29122-68-7] 5 gA beta-adrenoceptor antagonist; antihypertensive; antianginal. 25 gElijovich F, Laffer CL, Schiffrin EL. I Hum Hypertens. 11:313-9 (1997).

Plosker GL, Clissold SP. Drugs. 43:382-414 (1992).

A7656 Atomoxetine Hydrochloride 25 mgC17H21NO.HCl FW 281.82 [82248-59-7] 100 mgAtomoxetine is a selective noradrenaline reuptake inhibitor. It is used to treat 250 mgattention-deficit/hyperactivity disorder.

Oberlender, R. Nichols, DE. Ramachandran PV Srebnik M, J. Pharm Pharmacol. 39:1055-1056 (1987).

Kratochvil CJ. Vaughan, BS. Harrington MJ Burke WJ. Expert Opin Pharmacother. 4:1165-1174 (2003).

A7658 Atorvastatin Calcium Trihydrate (See page 26) 10 mg(C33H34FN2O5)2Ca. 3HCl FW 1209.42 [134523-03-8] 50 mgActive hydroxy acid which works to restore cholesterol homeostasis. Inhibits 100 mgHMG-CoA which leads to apoptosis of tumor cells.

Manlinowski, J. Am. J. Health-Syst. Pharm. 55:2253.

Guijarro, C., Blanco-Colio, L.M., Ortego, M., et al. Circ. Res. 83:490-500 (1998).

A7657 Atosiban Acetate 0.5 mgC43H67N11O12S2 FW 994.2 [914453-95-5] 1 mgA competitive oxytocin and vasopressin antagonist by exhibiting high affinity for 2.5 mgboth receptors. It is used to treat preterm labors.Williams et. al. Adv Exp Med Biol. 449:473-479 (1998).

Bossmar T. J Perinant Med. 26:458-45 (1998).

A7668 Atracurium Besylate 50 mgC65H82N2O18S2 FW 1243.49 [64228-81-5] 100 mgA competitive neuromuscular blocking agent. 500 mgHughes R, Chapple DJ. Br J Anaesth. 53:31-44 (1981).

HO

CH3 CH3 H

H3C

C

CH3HOCH2

HO

CH3

CH3

OH

H

OH

CH2

H

OHH

OH H

OH

H

O

HOCH2

H

OHH

OH H

OH O

H H

H

OHOH

H

H

CH3

O

O

N

H3CO

H3CO

H3CO

OCH3

CH3

N

OCH3

OCH3

OCH3

OCH3

H3C

O O

O O

2C6H5SO3

c[Mpr-D-Tyr(OEt)-Ile-Thr-Asn-Cys]-Pro-D-Arg-Gly-NH2

OH

O

HO

H

O

H

OH

HO

HO

O

O

OH

HO

OH

H

HO

H

OH


A7669 Atrial Natriuretic Peptide (1-28), rat 0.5 mgC128H205N45O39S2 FW 3062.47 [88898-17-3] 1 mgA diuretic and natriuretic peptide isolated from rat atrial myocytes that exhibits 2.5 mgvasorelaxant activity.

Grammer RT, Fukumi H, Inagami T, Misono KS. Biochem Biophys Res Commun. 16(2):696-703 (1983).

A7670 Atriopeptin I 0.5 mgC83H135N29O30S2 FW 2083.31 1 mgA biologically active petide isolated from mammalian cardiac atria. A natriuretic 2.5 mgand diuretic peptide that selectively relaxes intestinal but not vascular smooth muscle strips. Currie et. al. Science. 223:67-69 (1984).

A7071 Atriopeptin II (rat, rabbit, mouse) 0.5 mgC98H156N34O32S2 FW 2386.67 1 mgA biologically active petide isolated from mammalian cardiac atria. It exhibits 2.5 mg strong natriuretic and diuretic activities that relaxes both intestinal and vascular

smooth muscle strips. Atriopeptin II also exhibits potent renal vasodilatating effects in rats.Oshima T, Currie MG, Geller DM, Needleman P. Circ Res. 54:612-616 (1984).

A7072 Atriopeptin III 0.5 mgC107H165N35O34S2 FW 2549.85 1 mgAn analogue of atrial natriuretic peptide that inhibits carotid body chemoreceptor 2.5 mg nerve activity induced by hypoxia.

He L, Dinger B, Fidone S. Am J Physiol Cell Physiol. 278: C845-852 (2000).

A7672 Atropine Sulfate 5 g(C17H23NO3)2

.H2O.H2O FW 694.84 [5908-99-6] 10 gAntimuscarinic drug that has antagonistic activity against alpha(1)-ARs. It is 25 gan effective bronchodilator.

Shinoura H, Tsujimoto G, Teranishi Y et al. Naunyn Schmiedebergs Arch Pharmacol. 366:368-71 (2002).

Klock LE, Miller TD, Morris AH et al. Am Rev Respir Dis. 112:371-6 (1975).

A8070 Auraptene 25 mgC19H22O3 FW 298.38 [495-02-3] 100 mgNatural product from citrus fruit. Exerts tumor-preventive action through 500 mg apoptosis and cell proliferation-dependent mechanisms. Increases the activities of Phase II drug-metabolizing enzymes in the liver and colon.

Tanaka T, Kawabata K, Kakumoto M et al. Cancer Res. 12:2550-6 (1998).

Mori H, Niwa K, Zheng Q et al. Mutat Res. 480:201-7 (2001).

A8071 Auriculin A 0.5 mgC104H168N38O33S2 FW 2542.86 1 mg

2.5 mg

A8077 Autocamtide 2 0.5 mgC65H118N22O20 FW 1527.8 1 mg

2.5 mg

A9435 Axitinib (See page 29 for more information) 5 mg C22H18N4OS FW 386.47 [319460-85-0] 25 mgA small molecule tyrosine kinase inhibitor. 100 mgWilmes L J Magn Reson Imaging 25(3):319-27

Rugo HS. J Clin Oncol. 23(24):5474-83

A9602 Azacitidine 100 mg C8H12N4O5 FW 244.20 [320-67-2] 250 mgAzacitidine and its deoxy derivative, decitabine (also known as 5-aza- 1 g2′deoxycytidine), are used in the treatment of myelodysplastic syndrome.Cihák A (1974). "Biological effects of 5-azacytidine in eukaryotes". Oncology 30 (5): 405–22.

H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide Bridge Cys7-Cys23)

H-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-OH (Disulfide Bridge Cys7-Cys23)

H-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-OH(Disulfide Bridge Cys7-Cys23)

H-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide Bridge Cys7-Cys23)

H-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-OH (Disulfide Bridge Cys7-Cys23)

H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Thr-Val-Asp-Ala-Leu-OH

O NHO

HO

H

OH

N

NO NH2


A9603 5-Aza-2'-deoxycytidine (Decitabine) 5 mgC8H12N4O4 FW 228.21 [2353-33-5] 10 mgIt is a hypomethylating agent. It hypomethylates DNA by inhibiting DNA 50 mgmethyltransferase.Kantarjian H, Issa JP, Rosenfeld CS, et al. (April 2006). "Decitabine improves patient outcomes in

myelodysplastic syndromes: results of a phase III randomized study". Cancer 106 (8): 1794–803

A9801 Azaperone 500 mgC19H22FN3O FW 327.40 [1649-18-9] 1 gButyrophenone tranqulizer, and neuroleptic. Exerts an alpha adrenergic blocking 5 gaction and retards pre-adrenoreceptor activation of heart rate in pigs.Gregory NG, Wilkins LJ. J Vet Pharmacol Ther. 9:164-70 (1986).

Hughes RN, Syme LA, Syme GJ. Psychopharmacology. 52:107-9 (1997).

A9803 Azathioprine 1 gC9H7N7O2S FW 277.26 [446-86-6] 5 gIs an immunosuppressant. It is a purine synthesis inhibitor which inhibits the 10 g proliferation of cells.

Chebli J. Journal of gastroenterology and hepatology (2007), 22(2), 268-74.

Rippin S J. Clinical nephrology (2007), 67(6), 374-80.

van de Nadort C. J. pediatric gastroenterology and nutrition (2007), 45(4), 490.

A9817 Azelaic acid 5 gC9H16O4 FW 188.22 [123-99-9] 25 gA naturally occurring dicarboxylic acid. It is non-toxic, non-teratogenic, and

non-mutagenic. It is cytotoxic to melanocytes of human melanoma.Nazzaro-Porro M. Passi S. Zina G. et al Lancet 1:1109-1111 (1980).

A9818 Azelastine HCl 100 mgC22H24ClN3O FW 418.37 [79307-93-0] 500 mgH1-Histamine receptor antagonist. It inhibits the release of leukotriene C4 and 1 g D4, and TNF -alpha.Hamamoto Y, Nagai K, Muto M, Asagami C. Exptal Derm. 2:231-235 (1993).

Katayama S, Tsunoda H, Sakuma Y et al. Int. Arch Allergy Appl Immun. 83:284-289 (1987).

A3212 3'-Azido-3'-deoxythymidine 25 mg AZT, Azidothymidine, Zidovudine 100 mgC10H13N5O4 FW 267.24 [30516-87-1] 250 mgAntiviral agent. Effective against HIV. 1 g

A9834 Azithromycin 500 mgC38H72N2O12 FW 748.98 [83905-01-5] 1 gA 16-membered ring macrolide found to have potent antibacterial action against 5 ggram-negative organism.

Retsema J, Girard A, Schelkly W et al. Antimicrob Agents Chemother. 31:1939-47 (1987).

A9978 Aztreonam 10 mgC13H17N5O8S2 FW 435.43 [78110-38-0] 50 mgA synthetic monobactam antibiotic. 250 mgStutman HR, Welch DF, Scribner RK et al. Antimicrob Agents Chemother. 25:93-97 (1984).

Paradelis AG, Stathopoulis GA, Salpigides GN et al. Method Find Exp Clin. 5:375-383 (1983).

AZT (See 3'Azido-3'deoxythymidine)

B0000 2B-(A) 1 mgC81H137N28o28S FW 1983.23 2 mg

5 mg

B0072 2B-(S) 1 mgC81H137N28O28S FW 1983.23 2 mg

5 mg

Biotin-Arg-Arg-Ala-Ala-Glu-Glu-Leu-Asp-Ser-Arg-Ala-Gly-Ala-Pro-Gln-Leu-OH

Biotin-Arg-Arg-Ala-Ala-Glu-Glu-Leu-Asp-Ser-Arg-Ala-Gly-Ala-Pro-Gln-Leu-OH

OH

O

OHO


B0110 Baclofen (See page 21 for more information) 1 gC10H12ClNO2 FW 213.66 [1134-47-0] 5 gA GABA-b receptor agonist. 10 gBrogden RN, Speight TM, Avery GS. Drugs 8:1-14 (1974).

B0108 Bactenecin, bovine 0.5 mgC63H118N24O13S2 FW 1483.9 [116229-36-8] 1 mgA 12-amino acid cationic antimicrobial peptide from bovine neutrophis found to be

cytotoxic to neuronal and glial cells.Wu M, Hancock RE. J Biol Chem. 274:29-35 (1999).

Radermacher SW, Schoop VM, Schluesener HJ. J Neurosci Res. 36:657-62 (1993).

B0025 Bafilomycin A1 50 µgC35H58O9 FW 622.8 [88899-55-2] 5 x 50 µgMacrolide isolated from Streptomyces sp. that has been shown to decrease 1 mgmulti-drug resistance. It also has shown apoptotic and antibiotic properties.Altan et al. Journal of Experimental Medicine.187:1585 (1998).

Montcourrier P et al. Clinical & Experimental Metastasis. 15:382(1997).

Martinez-Zaguilan R et al. Biochemical Pharmacology. 57:1037(1999).

B0026 Bafilomycin B1 1 mgC44H65NO13 FW 815.99 [88899-56-3]Macrolide isolated from Streptomyces sp. that exhibits antibiotic properties.

Werner G, Hagenmaier H, Drautz H et al. Journal of Antibiotics. 37:110-7 (1984).

B0133 Baicalin (See page 15 for more information) 1 mgC21H18O11 FW 446.36 [21967-41-9] m.p. 223oC 5 mgBaicalin is a flavonoid found in the radix of Scutellaria baicalensis that 10 mghas antioxidant activity. It has anti-inflammatory effects, anti-HIV activity,

apoptosis induction and inhibition of colon aberrant crypts properties.

GAo Z, Huang K, Yang X, Xu H. Biochem Biophys Acta. 1472:643-650 (1999).

Lin CC, Shieh DE. Am. J. Chin. Med. 24:31-36 (1996).

Kitamura K, Honda M, Yoshizaki H et al. Antiviral Res. 37:131-140 (1998).

Wu X, Akatsu H, Okada H. Jpn J Med Sci. Biol. 48:79-87 (1995).

B0109 Bakuchiol 10 mgC18H24O FW 256.38 [10309-27-2] 25 mgInhibitor of protein tyrosine phosphatase 1B (PTB1B). Antioxidant. Inhibitor of 100 mgmitochondrial lipid peroxidation. Inhibitor of inducible nitric oxide synthase (iNOS; NOS II) expression. DNA polymerase inhibitor. Shows antimicrobial and

cytotoxic activity.E.J. Park, et al.; Eur. J. Pharmacol. 559, 115 (2007)

A0248 BAM-12P 1 mgH-Try-Gly-Gly-Phe-Met-Arg-Arg- C62H97N21O16S FW 1424.66 [75513-71-2] 2 mgVal-Gly-Arg-Pro-Glu-OH Dodecapeptide isolated from bovine adrenal medulla. It is a Pro-Met-enkephalin 5 mg

precursor.Mizuno K, Minamino N, Kangawa K, Matsuo H. Biochem Biophys Res Commun. 29:1482-8 (1980).

A0249 BAM-22P 1 mgC130H184N38O31S2 FW 2839.28 2 mg

5 mg

B0150 Bambuterol Hydrochloride 500 mgC18H29N3O5

.HCl FW 403.91 [81732-46-9] 1 gA bronchodilator. It inhibits plasma cholinesterase during metabolism and 5 gprolongs suxamethonium-induced neuromuscular blockade.Bang U, Viby-Mogensen J, Wiren JE et al. Acta Anaethesiol Scand. 34:596-9 (1990).

Sitar DS, Aoki FY, Warren CP et al. Chest. 103:771-6 (1993).

BCNU (See Carmustine)N,N'-Bis(2-chloroethyl)-N-nitrosourea

Arg-Leu-Cys-Arg-lle-Val-Val-lle-Arg-Val-Cys-Arg(Disulfide bridge Cys3-Cys11)

H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH

HO


B1603 Beauvericin 1 mgC45H57N3O9 FW 783.95 [26048-05-5] 5 mgA mycotoxin derived from the mold Beauveria bassiana, shows cytotoxic,

immunosuppressant, and apoptotic activity. It is the most potent specific inhibitor of

cholesterol acyltransferase and possesses ionophoric properties.

Chen BF, Tsai MC, Jow GM. 2006 Feb 3;340(1):134-9.

Kouri K, Duchen MR, Lemmens-Gruber R. Chem Res Toxicol. 2005 Nov;18(11):1661-8

B1753 Benfotiamine 250 mgS-Benzoylthiamine O-monophosphate 1 gC19H23N4O6PS FW 466.453 [22457-89-2] 5 gA lipid-soluble thiamine derivative found in Allium family vegetables such as garlic, onions,

leeks and shallots. As a treatment for diabetic neuropathy, benfotiamine is more effective at

increasing thiamine levels in blood and tissues than water-soluble salts like the previous vitamin B1.

Altern Med Rev.11: 238-242 (2006).

Marchetti et. al.Diabetes. 55: 2231-7 (2006).

B1545 Benzalkonium Bromide 100 g[91080-29-4] 500 gUlcerative agent. Preservative in most ophthalmic topical solutions. On epithelial conjunctival

cells in vitro, cells die by necrosis at high concetrations and by apoptosis at low concentration.

Wilmer JL, Burleson FG, Kayama F et al. J Invest Dermatol. 102:915-22 (1994).

De Saint Jean M, Brignole F, Bringuier AF et al. Invest Ophthalmol Vis Sci. 40:619-30 (1999).

B1652 Benzo[a]pyrene (See page 11 for more information) 500 mgC20H12 FW 252.32 [50-32-8] 1 g An environmental carcinogen found in automobile exhaust, jet engine exhaust, coal

tar, tobacco smoke, etc. It is carcinogenic to laboratory animals.

Henry MC, Port CD, Kaufman DG. Cancer Res. 35:207-217 (1975).

Smith DM, Rogers AE, Herndon BJ, Newberne PM. Cancer Res. 35:11-16 (1975).

B1755 Benzimidazole 5 gC7H6N2 FW 118.14 [51-17-2] 50 gHeterocyclic aromatic organic compound 250 gH. A. Barker, R. D. Smyth, H. Weissbach, et al. J.Biolog. Chem. 235 (2): 480–488 (1960).

B1853 1,4-Benzoquinone 100 gC6H4O2 FW 108.09 [106-51-4] 500 gIt is one of the major metabolites of benzene. It causes DNA damage and

apoptosis through H2O2 generation in cells.

S-Benzoylthiamine O-monophosphate (See Benfotiamine)

B1640 Benzydamine Hydrochloride 5 gC19H23N3O.HCl FW 345.87 [132-69-4] 25 gLocally acting nonsteroidal anti-inflammatory with local anesthetic and analgesic properties.

properties. Prostaglandin synthetase inhibitor.

B1855 O6-Benzylguanine 50 mgC12H11N5O FW 241.25 [19916-73-5] 250 mgA guanine analogue with antineoplastic activity. 1 gDolan ME, Pegg AE. Clin. Cancer Res. 3:837-847 (1997).

B1653 Benzyl isothiocyanate (See page 8 for more information) 5 gC8H7NS FW 149.22 b.p. 242-243oC [622-78-6] d. 1.125 10 gInhibitor of methylazoxymethanol acetate-induced intestinal carcinogenesis.

Sugie S, Okamoto K, Okumura A et al. Carcinogenesis. 8:1555-1560 (1994).

N

NH3C NH2

N

CH3

OS

OP

O

OHOH

O

N

OO

O

O

N

O

O

N O

OO

N

N N

HN

H2N

O


B1654 Benzyl selenocyanate (See page 12 for more information) 50 mgC8H7NSe FW 196.11 [4671-93-6] 100 mgA versatile synthetic organoselenium chemopreventive agent. Found 500 mgto be effective in several animal tumor model systems.

Fiala ES, Sohn OS, Li H et al. Carcinogenesis. 9:1809-1815 (1997).

B1655 S-(N-Benzylthiocarbamoyl)-L-cysteine (See page 8) 500 mgC11H14N2O2S2 FW 270.37 m.p. 191-193°C [35446-36-7 ] 1 gCysteine conjugate of benzyl isothiocyanate. 5 g

B1656 Benzyl thiocyanate, 97% 10 gC8H7NS FW 149.21 [3012-37-1] 50 gEffective against methylazoxymethanol acetate-induced intestinal carcinogenesis.

Sugie S, Okamoto K, Okumura A, Tanaka T, Mori H. Carcinogenesis. 8:1555-1560 (1994).

B1870 Berberine hydrochloride hydrate 5 gC20H18NO4

+Cl- FW 371.82 [633-65-8] 10 gIt is an isoqinoline alkaloid found in plants. It was shown to have chemopreventive

properties against colon tumor formation by inhibiting the enzyme

cyclooxygenase-2 (cox-2) and Activator Protein 1 (AP-1 ).

Fukuda k et. al. Journal of Ethnoph. 66:227-33 (1999).

Fukuda k, Hibiya Y, Mutah M et al. Planta Med. 65:381-3 (1999).

B1769 Bergenin 1 mgC14H16O9

.H2O FW 346.3 [477-90-7] 5 mgBergenin is an isocoumarin isolated from various medicinal plants. 10 mgIt shows mild anti-HIV activity and has antihepatotoxic and antiulcer activity.Lim HK, Kim HS, Chung MW, Kim YC. J. Ethnopharmacol. 70:69-72 (2000).

Goel RK, Maiti RN, Manickam M, Ray AB. Indian J. Exp. Biol. 35:1080-1083 (1997).

Liu W. Chung Kuo Chung Yao Tsa Chih. 16:102-104, 128 (1991).

B1668 Berteroin, 97% 25 mgC7H13NS2 FW 175.43 [4430-42-6] 50 mgBerteroin protects against metastaticity as well as cell growth of tumor cells. 100 mgSasaki T, Kudoh K, Uda Y, Ozawa Y, Shimizu J, Kanke Y, Takita T. Nutr. Cancer. 33: 76-81 (1999). 500 mg

B1874 Bestatin Hydrochloride 1 mgC16H24N2O4

.HCl FW 344.87 [65391-42-6] 5 mgIt is a specific inhibitor against aminopeptidase B and leucine aminopeptidase. 10 mgIt has also exhibits a direct antileukemic and antitumor effect against non-small cell cancer through induction of apoptosis.

Sekine K, Fujii H., Abe F. Leukemia. 13:729-34 (1999).

Ezawa K, Minato K., Dobashi K. Biomed Parmacother. 50:283-9 (1996).

B1876 Betamethasone 100 mgC22H29FO5 FW 392.46 [378-44-9] 500 mgA Glucocorticoid. It induces gene expression and apoptosis.Hofmann TG, Hehner SP, Bacher S et al. FEBS Lett. 441:441-6 (1998).

Kalthoff FS, Chung J, Musser P et al. Clin Exp Immunol. 133:350-9 (2003).

B1879 Betamethasone Valerate 100 mgC27H37FO6 FW 476.58 [2152-44-5] 500 mgis a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.Sommer, S, British Journal of Dermatology (2002), 147(2), 266-269.

B1878 Betamethasone 21-phosphate sodium salt 250 mgC22H28FNa2O8P FW 516.40 [151-73-5] 1 gA water soluble, anti-inflammatory glucocorticoid.

It has exhibited an antiulcerative effect on colonic lesions.Kitano A, Matsumoto T, Tabata A et al. Nippon Shokakibyo Gakkai Zasshi. 90:24-32 (1993).

Faro CJ, Reidelberger RD, Palmer JM. Am J Physiol Regul Integr Comp Physiol. 278:118-24 (2000).

O

F

H

HO

H

OOH

O

O


B1979 Betulinic acid 10 mgC30H48O3 FW 456.70 [472-15-1] 50 mgA naturally occurring pentacyclic triterpenoid which has anti-retroviral, anti-malarial, 250 mgand anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase.Chowdhury AR, Mandal S, Mittra B, et al. Med Sci Monit. 7:BR254-65 (2002).

B1898 Bezafibrate 1 gC19H20ClNO4 FW 361.82 [41859-67-0] 5 gA peroxisome proliferator and hypolipidaemic agent. A derivative of clofibrate. 25 g It has been shown to be effective in preventing mammary tumors induced by radiation

together with DES, possibly by reducing prolactin and triglyceride concentrations.Inano H, Suzuki K, Wakabayashi K. Carcinogenesis. 17:2641-6 (1996).

Goll V, Viollon-Abadie C, Nicod L et al. Hum Exp Toxicol. 19:193-202 (2000).

B3203 Biapenem 10 mgC15H18N4O4S FW 350.39 [120410-24-4] 25 mgA parenteral carbepenem that exhibits antibacterial activities against a wide 100 mg range of gram-positive and –negative bacteria.

Aldridge K, Morice N, Schiro D. Antimicrob Agents Chemother. 38: 889-93(1994).

B3209 Bicalutamide (See page 3 for more information) 100 mgC18H14F4N2O4S FW 430.37 [90357-06-5] 250 mgA nonsteroidal antiandrogen which has been shown effective in the treatment of 1 g prostate cancer. It has also been shown to induce cell death by a pathway that is

independent of changes in mitochondrial membrane potential and Bcl-2 actions.Maucher A, von Angerer E. J Canc Res Clin Oncol. 119:669-74 (1993).

Lee EC, Zhan P, Schallhom R et al. Cell Death & Differentiation. 10:761-71 (2003).

B3210 R-Bicalutamide (See page 3 for more information) 100 mgC18H14F4N2O4S FW 430.37 [113299-40-4] 250 mgA chiral nonsteroidal antiandrogen which has been shown to inhibit CYP3A4, 1 gwith lesser effect on CYP2C9, 2C19 and 2D6.

Cockshott ID. Clin Pharmacokinet. 43: 855-78 (2004).

B3320 Bifonazole 1 gC22H18N2 FW 310.39 [60628-96-8] 5 gAn imidazole antifungal agent and calmodulin antagonist. It causes a reduction 25 gin glycolysis and ATP levels in B16 melanoma cells.

Penso J, Beitner R. Eur J Pharmacol. 342:113-7 (1998).

Glass-Marmor L, Morgenstern H, Beiter R. Eur J Pharmacol. 313:265-71 (1996).

B3324 Big Endothelin-1 (1-38), human 0.5 mgC189H282N48O56S5 FW 4282.96 [124363-98-0] 1 mgA vasoconstrictor peptide that induces slow developing, long-lasting, and strong 2.5 mg vasoconstriction, indicating its physiological importance in vascular homeostasis.

Kimura et. al. J Cardiovasc Pharmacol. 13 (Suppl 5): discussion S18 (1989).

B3345 Bilobalide 5 mgC15H18O8 FW 326.30 [33570-04-6] 10 mgNaturally occurring diterpene from Ginkgo biloba. It has anti-ischemic and 25 mganti-convulsant properties.

Janssens D, Remacle J, Drieu K, Michiels C. Biochem Pharmacol. 58:109-19 (1999).

Sasaki K, Hatta S, Haga M, Ohshika H. Eur J Pharmacol. 367:165-73 (1999).

B3358 Biochanin A (See page 14 for more information) 100 mg5,7-Dihydroxy-4'-methoxyisoflavone 250 mgC16H12O5 FW 284.26 m.p. 210-213oC [491-80-5] 1 gAn isoflavone with anticancer proliferation, differentiation and chemopreventive

effects. Inhibits metabolic activation of benzo[a]pyrene.

Chae Y.-H, Ho DK, Cassady JM et al. Chem. Biol. Interactions 82: 181-193 (1992).

Jing Y, Waxman S. Anticancer Res. 15(4): 1147-1152 (1995).

N

N

O

O

OCH3

OH

HO

OO

O

H

OH

H

OO

O

OH

C(CH3)3

N

F F

F

NH

O

S

F

O

O

HO CH3

N

F F

F

NH

O

S

F

O

O

HO CH3

H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser-OH(Cys1-Cys15, Cys3-Cys11)


B3458 Biopterin 5 mgC9H11N5O3 FW 237.22 [22150-76-1] 10 mgAn obligate cofactor of inducible nitric oxide synthase. 25 mgWeinberg JB, Misukonis MA, Shami PJ et al. Blood 86:1184-95 (1995).

B3278 Biotin 500 mgD-Biotin;Vitamin H 1 gC10H16N2O3S FW 244.31 [58-85-5] 5 gA coenzyme that offers three possible binding sites. Used for pretargeted therapy, 10 gwhich increases the amount of radioactivity delivered to a cancer cell.Sigel H. Experientia. 37:789-98 (1981).

Correa-Gonzalez L, Arteaga de Murphy C, Ferro-Flores G et al. Nucl Med Biol. 30:135-40 (2003).

B3374 Bisacodyl 10 gC22H19NO4 FW 361.39 [603-50-9] 25 gA diphenolic laxative. It is suggested that intestinal inhibition of (Na+K+) ATPhase activity,

increase of mucosal PGE2 content, and possibly also stimulation of adenyl cyclase activity

might contribute to the net water accumulation induced by bisacodyl.Farack UM, Nell G. Digestion. 30:191-4 (1984).

Rachmilewitz D, Karmeli F, Okon E. Dig Dis Sci. 25:602-8 (1980).

B3373 Bisazir 500 mgBis(aziridinyl)methylamino phosphine sulfide 1 gC4H12N3SP FW 177.21 [13687-09-7] 5 g

B3272 Bis(3,5-dibromosalicyl) fumarate 100 mgC18H8O8Br4 FW 671.87 m.p. 225-228oC [71337-53-6] 500 mgPotent acylating agent of intracellular hemoglobin that cross-links beta chains 1 gof hemoglobin. 5 gWalder JA, Zaugg RH, Walder RY et al. Biochemistry. 18:4265-4270 (1979).

Zaugg RH. Walder JA, Walder RY et al. J Biol Chem. 255:2816-21 (1980).

B3275 Bis(3,5-dibromosalicyl) succinate 100 mgC18H10O8Br4 FW 673.89 m.p. 194-196oC [71337-52-5] 500 mgPotent acylating agent of intracellular hemoglobin. It cross-links beta chains 1 gof hemoglobin. 5 gWalder JA, Zaugg RH, Walder RY, Steele JM, Klotz IM. Biochemistry, 18:4265-4270 (1979).

Zaugg RH, Walder JA, Walder RY, Steele JM, Klotz IM. J. Biol. Chem., 255:2816-21 (1980).

B3280 Bis(salicyl) fumarate 100 mgC18H12O8 FW 356.29 m.p. 178-180oC 500 mgPotent acylating agent of intracellular hemoglobin. It cross-links beta chains 1 gof hemoglobin. 5 gZaugg RH, Walder JA, Walder RY et al. J Biol Chem. 255:2816-21 (1980).

B3577 Bitertanol 1 gC20H23N3O2 FW 337.42 [55179-31-2] 5 gA triazole fungicide. 25 gZaugg RH, Walder JA, Walder RY et al. J Biol Chem. 255:2816-21 (1980).

B4402 Blasticidin S Hydrochloride 25 mgC17H26N8O5

.HCl FW 458.5 [3513-03-9] 50 mgAn aminohexosylcytosine nucleoside that inhibits protein synthesis. 100 mgIt has also been shown to induce apoptosis in certain models.Johnson CR, Jiffar T, Fischer UM et al. Leukemia. 17:2140-8 (2003).Petropoulos AD, Xaplanteri MA, Dinos GP et al. J of Biol Chem. 279:26518-25 (2004).

B4517 Bleomycin A5 Hydrochloride (See page 3 for more info) 5 mgPingyangmycin 10 mgC57H89N19O21S2

.nHCl FW 1440.56 [55658-47-4] 25 mgPingyangmycin is an antitumor antibiotic. It induces apoptosis.

Tai KW, Chou MY, Hu CC, Yan, JJ, Chang YC. Oral Oncol. 36:242-7 (2000).

Li XT. Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao. 12:182-6 (1990).

HN

N N

N

O

H2N

C C

H

OH

H

OH

CH3

NHHN

S

HH

O

OH

O

N

OH3C O CH3

O O

O C

C OH

H

O

O

Br

CO2H

CO2HBr

Br

Br

N P N

NH

S

CH3

OCH2CH2

O

O

O

Br

CO2H

CO2H

Br

Br

Br

O O

H

H

O

OCO2H

CO2H

N

N

O

NH2

NHN

H3C

ONH2

NHH2N

O

HOOC

.HCL

NH2

HN

HN

O

N

SN

S

HN

ONH

HO

O

HN

O

O

O

O

OH O

O

HO

HO

HO OH

O

H2N

O

N

N

HN

O

N

N

H2N

H2N

O

NH

NH2

H2N

O

O O

H

H

O

OCO2H

CO2H


B4518 Bleomycin sulfate (See page 3 for more information) 5 mgC55H84N17O21S3

.H2SO4 FW 1512.63 [9041-93-4] 10 mg1.5-2.0 Units per mg. 25 mgA glycopeptide antibiotic consisting of a mixture of bleomycin sulfate salts.

Bleomycin A2 is pictured.

Lown JW, Sim S-K. Biochem. Biophys. Res. Commun. 77: 1150 (1977).

Haidle CW, Lloyd RS. Antibiotics 5: 124 (1979).

B5560 BNP (1-32), rat 0.5 mgC146H239N47O44S3 FW 3453.01 [133448-20-1] 1 mgA brain diuretic-natriuretic and vasorelaxant peptide found in the brain and atrium 2.5 mgof rats.Kojima M, Minamino N, Kangawa K, Matsuo H. Biochem Biophys Res Commun. 159: 1420-6 (1989).

B5561 BNP (1-32), human 0.5 mgC143H244N50O42S4 FW 3464.1 [114471-18-0] 1 mgA brain natriuretic peptide secreted by the human heart in response to cardiac 2.5 mgvolume or pressure.

Al-Meslmani BM, Fahoum SK, Shamia MG. Clin Lab. 53: 35-9 (2007).

B5608 Boc-FAAGRK-AMC 20 mgC44H63N11O6 FW 906.0

B5609 Boc-GRR-AMC 20 mgBoc-Gly-Arg-Arg-AMC C29H44N10O7 FW 644.7

B5610 Boc-PRR-AMC 20 mgBoc-Pro-Arg-Arg-AMC C32H48N10O7 FW 684.8

B5611 Boc-RRR-AMC 20 mgBoc-Arg-Arg-Arg-AMC C33H53N13O7 FW 743.8

B5648 Bombesin 1 mgC71H111N24O18S FW 1619.86 [31362-50-2] 2 mgA gut tetradecapeptide with the ability to stimulate the release of numerous 5 mg hormones. It inhibits growth of pancreatic ductal adenocarcinoma (H2T) in nude mice.

Chen LW, Hsu CM, Huang JK et al. J Formos Med Assoc. 99:491-8 (2000).

Farre A, Ishizuka J, Gomez G et al. Pancreas. 9:652-6 (1994).

B5649 [Tyr4] Bombesin 1 mgC74H108N24O19S FW 1669.9 2 mg

5 mg

B5753 Bongkrekic acid (See page 18 for more information) 100 µgC28H38O7 FW 486.60 [11076-19-0]

A mitochondrial permeability transition pore blocker. It has been shown to inhibit apoptosis

by preventing PARP cleavage and DEVDase activity.

Yoon HS, Moon SC, Kim ND et al. Biochem Bioph Res Co. 276:151-6 (2000).

Zamora M, Granell M, Mampel T et al. FEBS Letters. 563:155-60 (2004).

B5871 Bortezomib 5 mgC19H25BN4O4 FW 384.24 [179324-69-7] 25 mgA proteasome inhibitor. Bortezomib has demonstrated impressive antitumor activity 100 mgand manageable toxicities in Phase I and II trials both as a single agent, and in

combination with other drugs.

Voorhees PM, Dees EC, O'Neil B, Orlowski RZ. Clin Cancer Res. 9(17):6316-25 (2003).

N N

HN

OO

NH

HO

CH3

NH

N

S

CH3

H2N

C

O

NH2HN

CONH2

NH2

O

NH

N

OO

HO

OH

HO

O

OHO

O NH2

OH

OH

S

N

O

NH

HN

O

CH3

OH

O

CH3

SH3C CH3

. H2SO4

H-Asn-Ser-Lys-Met-Ala-His-Ser-Ser-Ser-Cys-Phe-Gly-Gln-Lys-Ile-Asp-Arg-Ile-Gly-Ala-Val-Ser-Arg-Leu-Gly-Cys-Asp- Gly-Leu-Arg-Leu-Phe-OH (Disulfide Bridge Cys10-Cys26)

H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg- Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys- Val-Leu-Arg-Arg-His-OH (Disulfide Bridge Cys10-Cys26)

Boc-Phe-Ala-Ala-Gly-Arg-Lys-AMC

pGlu-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2

pGlu-Gln-Arg-Tyr-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2

HO2C

CO2H

H3C

H3CO

HO2C CH3

CH3

N

NNH

OHN

O B

OHHO


B5874 Bosutinib 10 mg C26H29Cl2N5O3 FW 530.45 [380843-75-4] 25 mgBosutinib is a tyrosine kinase inhibitor undergoing research for use in the 100 mg treatment of cancer.

Vultur, A. Molecular Cancer Therapeutics (2008), 7(5), 1185-1194.

Vultur, Adina Molecular Cancer Therapeutics (2008), 7(5), 1185-1194.

Bothrops alternatus (See snake venom)

Bothrops neuwiedi diporus (See snake venom)

B6800 Bradykinin triacetate 10 mgC50H73N15O11 FW 1240.38 [5979-11-3] 20 mgA pro-inflammatory polypeptide that is an important mediator of hyperalgesia, 50 mginflammatory diseases, asthma and cancer. It has been shown to possesspotent anti-cancer activities in both in vitro and in vivo cancer models.Stewart JM. Curr Pharm Des. 9:2036-42 (2003).Sharma JN, Al-Dhalmawi GS. Drugs. 6:581-6 (2003).

B6802 Bradykinin (1-3) 5 mgH-Arg-Pro-Pro-OH C16H28N6O4 FW 368.4 [58-82-2] 10 mg

25 mg

B6803 Bradykinin (1-5) 5 mgC27H40N8O6 FW 572.67 10 mg

25 mg


25 mg


25 mg


25 mg

B6807 Bradykinin [Des-Arg9] 5 mgC44H61N11O10 FW 904.04 10 mg

25 mg

B6808 Bradykinin [Des-Pro2] 5 mgC45H66N14O10 FW 963.12 10 mg

25 mg

B6809 Bradykinin [DPhe7] 1 mgC54H75N15O11 FW 1110.29 2 mg

5 mg

B6810 Bradykinin [Hyp3] 0.5 mgC30H72N15O10 FW 1077.23 1 mg

2.5 mg

B6811 [Tyr8] Bradykinin 5 mgC50H73N15O12 FW 1076.23 10 mg

50 mg

B6812 Bradykinin Potentiator B 5 mgC56H91N15O13 FW 1182.46 10 mg

25 mg

N

HN

CN

OMe

Cl Cl

MeO

ON

N

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

H-Arg-Pro-Pro-Gly-Phe-Ser-OH

H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-OH

H-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH

H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-OH

H-Arg-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH

H-Arg-Pro-Pro-Gly-Phe-Ser-DPhe-Phe-Arg-OH

H-Arg-Pro-Hyp-Gly-Phe-Ser-Pro-Phe-Arg-OH

H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Tyr-Arg-OH

pGlu-Gly-Leu-Pro-Pro-Arg-Pro-Lys-Ile-Pro-Pro-OH

H-Arg-Pro-Pro-Gly-Phe-OH


B6813 Bradykinin Potentiator C 5 mgC51H77N11O13 FW 1052.26 10 mg

25 mg

B3346 Brain injury-derived Neurotrophic Peptide (3) 1 mgBINP 2 mgC62H101N17O19 FW 1388.58 5 mg

B6801 Brassinin (See page 11 for more information) 50 mgC11H12N2S2 FW 236.36 m.p. 132-133oC [105748-59-2] 100 mgA phytoalexin found in Chinese cabbage. An effective inhibitor of stage two skin 250 mgcarcinogenesis. An inducer of Phase II enzymes and inhibitor of chemically induced carcinogenesis.Mehta RG, Liu J, Constantinou A et al. Carcinogenesis 16: 399-404 (1995).

B6816 Brefeldin A 5 mgC16H24O4 FW 280.36 [20350-15-6] 10 mgMacrolide possessing antifungal, antiviral and antitumor properties.

Misumi, Y., et al., J. biol. Chem. 261:11398 (1986).Mordente, J.A., Konno, S., Chen, Y. et al J. Urol 159:275-9 (1998).

Brevetoxins (See page 31 for more information)Brevetoxins are known to bind to site 5 of voltage-gated sodium channels in nerve

cells, leading to channel activation. This leads to disruption of normal neurological

processes and causes the illness clinically described as neurotoxic shellfish

poisoning (NSP). Sold by LKT under license from the manufacturer, MARBIONC.

B6916 Brevetoxin 1 (PbTx-1) 100 µgC49H70O13 FW 867.20 [98112-41-5] 1 mg



B6919 Brevetoxin 3 42-Acetate (PbTx-3 42-Acetate) 100 µgC52H74O15 FW 939.20 [1039726-95-8]

B7016 Brevetoxin 6 (PbTx-6) 100 µgC50H70O15 FW 911.20 [97938-23-3]



N

H

H

N C SCH3

S

O

HO

OH

O

H

CH3

pGlu-Gly-Leu-Pro-Pro-Gly-Pro-Pro-Ile-Pro-Pro-OH

Glu-Ala-Leu-Glu-Leu-Ala-Arg-Gly-Ala-lle-Phe-Gln-Ala

O

O

O

O O

O

O

O

O

O

O

H

O

OH

HHH

HH

H

HH

H

H

HH

HH H

H

O

O

O

O

O

O

O

OO

O O

O

HO

H

O

H HH

HH

H

H H HH

H H

H

H

H

O

O

O

O

O

O

O

OO

O O

O

HO

OH

H

H

H

HHH

HHH

H HH

HH

H

O

O

O

O

O

O

O

OO

O O

O

HO

O

H H HH

H H

H

H

HH

HH

HHH

O

O

O

O

O

O

O

O

OO

O O

O

HO

O

H H HH

H H

H

H

HH

HH

HHH

O

O

O

O

O

O

O

O

OO

O O

O

HO OH

H HH

H H

H

H

H

H H

H

HH

H

H



B7118 Brevetoxin 3 42-carboxylic acid (PbTx-COOH) 100 µgC50H70O15 FW 911.20 [55173-05-0]

B7119 β-Naphthoyl brevetoxin 100 µgC61H78O15 FW 1051.40 [2888-57-9]

B6935 Brivudine 10 mgC11H12BrN2O5 FW 333.13 [69304-47-8] 25 mgAn antiviral drug used in the treatment of herpes zoster. 100 mgAbraham, S. British Journal of Dermatology (2006), 154(2), 365-367.

B6957 Bromhexine Hydrochloride 100 gC14H20Br2N2

.HCl FW 412.60 [611-75-6] 500 gA mucolytic agent. Exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells in vivo.Takeda H, Abe Y, Misawa M et al. Jpn J Pharmacol. 35:445-50 (1984).

Gotz VH. Arzneimittelforschung. 25:607-15 (1975).

B6856 5-Bromo-2'-deoxyuridine 250 mgC9H11BrN2O5 FW 307.11 m.p. 193-197oC [59-14-3] 500 mg

1 g5 g

B6857 4'-Bromoflavone 1 gC15H9BrO2 FW 301.13 [1218-80-0] 5 gA potent Phase II detoxifying enzyme inducer. Inhibits DMBA-induced mammary 10 gtumorigenesis in the rat.Song, L. L., Kosmeder, J.W., Lee, S.K., et al Cancer Res. 59:578-585 (1999).

B7058 Brompheniramine Maleate 10 mgC16H19BrN2

. C4H4O4 FW 435.31 25 mgHalogenated alkylamine antihistamine. Antidepressant properties due to 100 mg reuptake inhibition of seratonin. Has analgesic-sparing effects on opiod analgesics

Park, Sang-Joon. Journal of Applied Toxicology (2008), 28(2), 104-111.

B6998 Bryostatin 1 10 µgC47H68O17 FW 905.03 [83314-01-6]It is a partial Protein kinase C (PKC) agonist that has potent antitumor

and immunomodulatory activity. It also enhances cytotoxicity of most

chemotherapeutic agents.Caponigro F, French RC, Kaye SB. Anticancer Drugs. 8:26-33 (1997).

Dowlati A et. al. American Society of Clinical Oncology Online (2000).

Koutcher J A et. al. Clinical Cancer Research. 6:1498-1507 (2000).

B8010 Buccalin 1 mgC45H72N12O15S FW 1053.20 [116844-51-0] 2 mgA modulatory neuropeptide. 5 mgCropper EC, Miller MW, Tenenbaum R et al. Proc Natl Acad Sci USA. 85:6177-81 (1988).

B8112 Budesonide 100 mgC25H34O6 FW 430.53 [51333-22-3] MP: 226oC 250 mgA glucocorticoid steroidal anti-inflammatory agent used for the treatment of 1 g asthma, non-infectious rhinitis and nasal polyposis. Budesonide is also know to be a potent chemopreventive agent in mice by decreasing the size of lung tumors, reversing DNA hypomethylation and altering mRNA gene expression.Pereira MA, Tao L, Liu Y, Li L, Steele VE, Lubet RA. Int J Cancer.120:1150-3 (2007).

O

O

Br

O O

OO

H

HH HO

HH

OAc

H

O

HO

CO2CH3

OHOH

O

O

CH3O

O

NH2

CH3

NBr

Br

N

N

O

O

Br

O

HO

HO

Gly-Met-Asp-Ser-Leu-Ala-Phe-Ser-Gly-Gly-Leu-NH2

N

Br

N

O

O

OH

OH

O

CH3

HO

H

H H

CH3

O

O

CH3

OOH

O

O

O

O O

O

O

O

O

O

O

OH

H

H H

H

H

H

HH

H

H H H

HHH

H

OH

O

O

O

O

O

O

O

OO

O O

O

HO

O

H

H

H

HHH

HHH

H HH

HH

H

OH

O

O

O

O

O

O

O

OO

O O

H

H

H

HO

H

HH

HH

H

OH H H

HH H

O O


B8144 Bulleyaconitine A (See page 19 for more information) 10 mgC35H49NO10 FW 643.76 [107668-79-1] 100 mgAn active principle component from Aconitum bulleyanum Diel has analgesic property.

Tang XC, Liu XJ, Lu WH. Acta Pharm Sinica. 21:886-891 (1986).

B8248 Bumetanide 250 mgC17H20N2O5S FW 364.42 [28395-03-1] 1 gDiuretic of the sulfamyl category to treat heart failure. An alternative to furosemide

Dzhala, V. Annals of Neurology (2008), 63(2), 222-235.

Lu, K. Neurological Research (2007), 29(4), 404-409.

Delpy A. J. of physiology (2008), 586(4), 1059-75.

B8261 Bupivacaine 1 gC18H28N2O FW 288.43 [38396-39-3] 5 gLocal anesthetic which binds to the intracellular portion of sodium channels and 25 gblocks sodium influx into the nerve cellsCoskuner, I. European Journal of Anaesthesiology (2007), 24(6), 535-540.

Kucukguclu, S. European Journal of Anaesthesiology (2008), 25(4), 307-313

Lee Sung-Jin. Anesthesia and analgesia (2008), 107(3), 824-7

B8262 Bupivacaine Hydrochloride 1 gC18H28N2O.HCl.H2O FW 342.91 [14252-80-3] 5 gLocal anesthetic with a cytotoxic effect on muscle fibers. Inhibits TREK-1 25 gchannels and depolarizes the cell membrane.Punke MA, Licher T, Pongs O et al. Anesth Analg. 96:1665-73 (2003).Nonaka I, Fujita T, Sugita H. Muscle Nerve. 7:400-7 (1984).

B8363 Bupropion Hydrochloride 50 mgC13H18ClNO.HCl FW 276.2 [31677-93-7] 250 mgA typical anti-depressant and anti-smoking aid that acts as a norepinephrine and 1 g dopamine reuptake inhibitor and nicotine antagonist.David, S. Nicotine & Tobacco Research (2007), 9(12), 1251-1257.

Piper, M. E. Nicotine & Tobacco Research (2007), 9(9), 947-954.

Dhir, A. European Journal of Pharmacology (2007), 568(1-3), 177-185.

B8271 Bursin 5 mgH-Lys-His-Gly-NH2 C14H25N7O3 FW 339.39 [60267-34-7] 10 mg

A tripeptide isolated from avian bursa of Fabricius that selectively induces 25 mg differentiation in B precursor cells nut to T precursor cells.

Audhya T, Viamontes G, Babu U, Goldstein G. Scand J Immunol. 31: 199-204 (1990).

B8274 Buspirone Hydrochloride 1 gC21H31N5O2

.HCl FW 421.97 [33386-08-2] 5 gAn azaspirodecanedione that has anxiolytic actions. Affects dopaminergic, serotonergic and

noradrenergic pathways, as well as the GABA-benzodiazepine receptor chloride ionophore complex.Skolnick P, Paul SM, Weissman BA. Pharmacotherapy. 4:308-14 (1984).

Dringenberg HC, Kornelsen RA, Vanderwolf CH. Pharmacol Biochem Behav. 49:741-6 (1994).

B7973 Busulfan / 1,4-Butanediol dimethanesulfonate 10 gC6H14O6S2 FW 246.30 m.p. 114-117oC [55-98-1] 25 gA DNA alkylating agent used as an antitumor drug. Effective in chronic myelocytic leukemia.

Fulmer Shealy Y. In "Cancer Chemotherapeutic Agents" Foye WO, Ed., (1995).

ACS Professional Reference, pp. 149-153, (1995).

B8278 Butoconazole nitrate 100 mgC19H18Cl3N3O3S- FW 474.79 [64872-77-1] 250 mgAn imidazole antifungal used in gynecology. 1 gBrown, D. Journal of Reproductive Medicine (1999), 44(11), 933-938.

B8174 Butylated Hydroxyanisole 50 gC11H16O2 FW 180.24 [25013-16-5] 100 gAn antioxidant that is a mixture of 2-tert-butyl-4-methoxyphenol and 3-tert-butyl-4-methoxy phenol. It induces phase II detoxifying enzymes that inhibit the action of carcinogens. Dietary BHA induces forestomach tumors.Ito N, Hirose M. Adv. Cancer Res. 53:247-302 (1989).

Ito N, Fukushima S, Tsuda H. CRC Crit Rev Toxicol. 15:109-150 (1985).

O

O

N

O

OOH

O

OO O

O

OSO2CH3

H2

C

H2C

H2C

CH2

OSO2CH3

OH

C(CH3)3

OCH3

N

O

NH

H3CH3C

CH3

N

N N

N

NO

O

S

Cl Cl

NN

ClN

OH

O

O

Cl

OHN

CH3

CH3

CH3

CH3

HCl

N

H3C

NH

OH3C

CH3

HN

O

HO

O

SH2N

O

O


B7977 Butylated hydroxytoluene (BHT) 100 gC15H24O FW 220.35 m.p. 69-70oC [128-37-0] 500 gAn antioxidant shown to be chemopreventive against a variety of

carcinogens. Low doses have a modulating effect on liver and bladder carcinogenesis.Williams GM, Tanaka T, Maruyama et al. Cancer Res. 51:6224-6230 (1991).

B8070 2-tert-Butyl-4-hydroxyanisole, 99% 100 mgC11H16O2 FW 180.25 [88-32-4] 500 mgMinor isomer of BHA mixture. It has different biological activity than 1 gthe 3-BHA isomer.

Lam LKT, Pai RP, Wattenberg LW. J Med Chem. 20:569-571 (1979).

Ito N, Hirose M, Urata Y et al. Gann. 75:471-474 (1984).

B8071 3-tert-Butyl-4-hydroxyanisole, 99% 10 gC11H16O2 FW 180.25 m.p. 58-60oC [121-00-6] 50 gAntioxidant used to stabilize fatty food. It was found to inhibit chemically-induced

tumor formation in animals. Under high dose conditions it was carcinogenicto the forestomach of rodents.Ito N, Hirose M. Adv. Cancer Res. 53:247-302 (1989).

Ito N, Fukushima S, Tsuda H. CRC Crit Rev Toxicol. 15:109-150 (1985).

WattenbergLW,Lam LKT.in"Inhibition of Tumor Induction and Development". M.S.ZedeckandM.Lipkin,eds.

pp. 1-22. Plenum Press, N.Y. (1981).

Fukuda K et. al. Journal of Ethnoph. 66:227-33 (1999).

Fukuda K, Hibiya Y, Mutah M et al. Planta Med. 65:381-3 (1999).

B8072 3-tert-Butyl-5-methoxy-catechol 10 mgC11H16O3 FW 196.25 m.p. 95-96oC [80284-15-7] 50 mgCytotoxic agents to P388 and KB cells. 100 mgLam LKT, Garg P, Swanson SM, Pezzuto JM. J Pharm Sci. 77: 393-5 (1988).

B8073 4-tert-Butyl-5-methoxy-catechol 10 mgC11H16O3 FW 196.25 m.p. 89-900C [91352-66-8] 50 mgCytotoxic agents to P388 and KB cells. 100 mgLam LKT, Garg P, Swanson SM, Pezzuto JM. J Pharm Sci. 77: 393-5 (1988).

B8074 3-tert-Butyl-5-methoxy-1, 2-quinone 50 mgC11H14O3 FW 194.25 m.p. 73-74oC [2940-63-8] 100 mgCytotoxic agents to P388 and KB cells. 500 mgLam LKT, Garg P, Swanson SM, Pezzuto JM. J Pharm Sci. 77: 393-5 (1988).

B8075 4-tert-Butyl-5-methoxy-1, 2-quinone 50 mgC11H14O3 FW 194.25 m.p. 92-95oC [36122-03-9] 100 mgCytotoxic agents to P388 and KB cells. 500 mgLam LKT, Garg P, Swanson SM, Pezzuto JM. J Pharm Sci. 77: 393-5 (1988).

B8176 2-n-Butylthiophene, 97% 5 gC8H12S FW 140.25 b.p. 181-1820C [1455-20-5] 10 g An inhibitor of DMH-induced aberrant crypt formation in colon.

Lam LKT, Zhang J. Carcinogenesis. 12:2311-2315 (1995).

B8275 n-Butyric acid 10 mlC4H8O2 FW 88.11 [107-92-6] 100 mlHas chemopreventive activity against colon cancer by inducing apoptosis.

Kellof G J et al. Journal of Cellular Biochemistry-Supplement. 20:1-24 (1994).

B8276 Butyric acid sodium salt 5 gSodium butanoate 25 gC4H7NaO2 FW 110.09 [156-54-7]A potent inhibitor of cell growth and differentiation inducer. It is shown that in

P53-mutated human colon cancer cells, butyrate activates the WAF1 promoter and induces

WAF1 protein production, which is an inhibitor of cyclin-dependent kinases.

Bartram HP, Scheppach W, Englert S et al. J Parenter Entera Nutr. 19:182-6 (1995).

Nakano K, Yamagashi H, Oka T, Sakai T. Nippon Geka Gakkai Zasshi. 99:373-8 (1998).

OH

C(CH3)3

OCH3

C C

CH3

OH

CH3H3C

H3C

H3CCH3

CH3

OH

C(CH3)3

OCH3

OCH3

C(CH3)3

OH

HO

OCH3

C(CH3)3

OH

HO

OCH3

O

O C(CH3)3

OCH3

O

O

C(CH3)3

S

H3C

O

OH

H3C

O

O Na


C0016 Caerulomycin A 1 mgC12H11N3O2 FW 229.23 [21802-37-9]Pyridine derivative antibiotic. Produced by several actinomycete species. Also known as cerulomycin.

Caerulomycin A is a fungicide that exhibit activities against human tumor cells.

Divekar P V et al. Can. J. Chem. 45: 1215 (1967)¸

McInnes A G et al. Can. J. Chem. 57: 3200 (1979).

C0019 Calcifediol 1 mgC27H44O2 FW 400.64 [19356-17-3] 5 mgA prehormone which is produced by hydroxylation of vitamin D3 (cholecalciferol) in the liverFleet J C. American journal of physiology (1999), 276(4 Pt 1), G958-64

C0020 Cafestol (See page 12 for more information) 50 mgC20H28O3 FW 316.44 m.p. 156-158oC [469-83-0] 100 mgNatural product isolated from the unsaponifiable fraction of petroleum ether 500 mg extract of coffee beans. It is an inducer of the detoxifying enzyme glutathione S-transferase.Bengis RO, Anderson RJ. J. Biol. Chem. 47:99-113 (1932).

Slotta KH, Neisser K. Ber. 71:1991-1994 (1938).

Lam LKT, Sparnins VL, Wattenberg LW. Cancer Res. 42:1193-1198 (1982).

C0021 Cafestol acetate (See page 12 for more information) 50 mgC22H30O4 FW 358.48 m.p. 163.5-165oC [81760-48-7] 100 mgInducer of glutathione S-transferase. 500 mg

C0025 Cafestol eicosanate (See page 12 for more information) 25 mgC40H66O4 FW 610.95 50 mg

100 mg

C0027 Cafestol linoleate (See page 12 for more information) 25 mgC38H58O4 FW 578.87 50 mg

100 mg

C0029 Cafestol oleate (See page 12 for more information) 25 mgC38H60O4 FW 580.88 50 mg

100 mg

C0022 Cafestol palmitate (See page 12 for more information) 50 mgC36H58O4 FW 554.43 m.p. 43oC [81760-46-5] 100 mgNaturally occurring ester present in green coffee beans. 500 mgLam LKT, Sparnins VL, Wattenberg LW. Cancer Res. 42:1193-1198 (1982).

C0033 Cafestol stearate (See page 12 for more information) 25 mgC38H62O4 FW 582.90 50 mg

100 mg

C0121 Caffeic acid (See page 10 for more information) 5 gC9H8O4 FW 180.16 m.p. 194-1980C 9dec.) [331-39-5] 25 gInhibitor of ornithine decarboxylase and protein tyrosine kinase.Rao CV, Desai D, Kaul B, Amin S, Reddy BS. Chem. Biol.Interactions 84:277-290 (1992).

C0221 Caffeine 10 g3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione 50 gC8H10N4O2 FW 194.19 [58-08-2] 100 gCaffine has inhibitory action against lung tumorigenesis, colonic carcinogenesis and UV-induced carcinogenesis.Chuang FL, Wang M, Rivenson A, Iatropoules MI et al. Cancer Res. 58:4096-101 (1998).

Hagiwara A, Boonyaphiphat P, Tanaka H et al. Jpn J Cancer Res. 90:399-405 (1999).

Lu YP, Lou YR, Li XH et al. Cancer Res. 60:4785-91 (2000).

C0246 Calcimycin 1 mgC29H37N3O6 FW 523.62 [52665-69-7] 5 mgInduces apoptosis in the lens epithelium, which leads to opacification. 10 mgLi WC, Kuszak JR, Wang GM et al. Exp. Eye Res. 61:91-8 (1995).

N

N

OCH3

N

OH

O H

O H

O

OCCH3

O H

O

O

OC(CH2)14C H3

O H

O

O

HO

HO

OH

O

O

OC(CH2)18CH3

OH

O

O

OC(CH2)6CH2

OH

O

CH2

(CH2)4CH3

O

OH

OC(CH2)6CH2

O

CH2(CH2)6CH3

O

OH

OC(CH2)16CH3

O

N

N

N

N

O

CH3

H3C

O CH3

O

O

O

N

CH3 CH2

CH3H3C

CH

H3C

C

O

NH

COOH

NHCH3

HO

OH


C0247 Calcineurin Autoinhibitory Peptide 0.5 mgC124H205N39O39S2 FW 2930.38 1 mgSpecific calcineurin inhibitor. Corresponds to a C-terminal domain 2.5 mg (residues 457-482) of the calmodulin-binding domain of calcineurin.

Hashimoto, Y.; Perrino, B. A.; Soderling, T. R. J. Biol. Chem. 265:1924(1990).

Perrino, B. A.; Ng, L. Y.; Soderlinget, T. R. J. Biol. Chem. 270:340 (1995).

C0248 Calcineurin Substrate 0.5 mgC92H150N28O29S FW 2112.4 [113873-67-9] 1 mg

2.5 mg

C0146 Calcitonin, chicken 0.5 mgC145H240N42O46S2 FW 3371.91 [9007-12-9] 1 mgA peptide hormone produced by thyroid cells, shown to inhibit osteoclasts activity. 2.5 mgLiu et. al. Sheng Wu Gong Cheng Xue Bao. 22: 539-44 (2006).

C0140 Calcitonin, eel 1 mgC146H241N43O47S2 FW 3414.94 2 mg

5 mg

C0148 Calcitonin, human 0.5 mgC145H240N44O48S2 FW 3417.88 [21215-62-3] 1 mgA carrier peptide that can be used to better internalize fusion proteins. 2.5 mgMachova Z, Muhle C, Krauss U et al. Chembiochem. 3: 672-677 (2002).

C0153 Calcitonin, rat 0.5 mgC148H228N40O46S3 FW 3399.9 1 mg

2.5 mg

C0149 Calcitonin, salmon 0.5 mgC151H226N40O45S3 FW: 3431.85 [47931-85-1] 1 mg

2.5 mg

C0244 α-Calcitonin Gene Related Peptide, chicken 0.5 mgC165H260N52O50S2 FW 3836.37 1 mgCalcitonin gene-related peptide is important for neurotransmission, 2.5 mgcardiovascular and respiratory function. It is released by motor neurons where it exerts

both short and long term effects on skeletal muscle fibers.

Nimmagadda D. G.S. Indian J. Pharmacol. 36:277 (2004).

Feuerstein, G. et al. Can. J. Physiol. Pharmacol. 73:1070 (1995).

C0151 α-Calcitonin Gene Related Peptide, human 0.5 mgC163H267N51O49S2 FW 3789.31 [90954-53-3] 1 mg

2.5 mg

C0245 Calcitonin Gene Related Peptide, rat 0.5 mgC162H260N50O52S2 FW 3804.33 1 mg

2.5 mg

C0243 Calcitonin Gene Related Peptide (8-37), human 0.5 mgC139H230N44O38 FW 3125.65 1 mg

2.5 mg

Asp-Leu-Asp-Val-Pro-lle-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu

H-Cys-Ala-Ser-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ala-Gly-Thr-Pro-NH2 (Disulfide Bridge Cys1-Cys7)

H-Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-AspVal-Gly-Ala-Gly-Thr-Pro-NH2 (Disulfide Bridge Cys1-Cys7)

Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-lle-Gly-Val-Gly-Ala-Pro-NH2(Disulfide bridge Cys1-Cys7)

H-Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Leu-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ser-Ile-Gly-Val-Gly-Ala-Pro-NH2(Disulfide Bridge Cys1-Cys7)

Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2(Disulfide bridge Cys1-Cys7)

H-Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Asp-Phe-Leu-Ser-Arg-Ser-Gly-Gly-Val-Gly-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (Disulfide Bridge Cys2-Cys7)

Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2(Disulfide bridge Cys2-Cys7)

H-Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2(Disulfide Bridge Cys2-Cys7)

H-Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys-Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg-Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-OH

H-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2


C0249 Calcitonin Gene Related Peptide (8-37), rat 0.5 mgC138H224N42O41 FW 3127.58 1 mg

2.5 mg

C0250 Calcitonin Gene Related Peptide II, human 0.5 mgC162H267N51O48S3 FW 3793.38 1 mg

2.5 mg

C0251 Calcitonin Gene Related Peptide II, rat 0.5 mgC163H265N51O50S2 FW 3803.39 1 mg

2.5 mg

C0145 Calcitriol 50 µg1 alpha, 25-Dihydroxyvitamin D3 5 x 50 µgC27H44O3 FW 416.64 [32222-06-3] 1 mgThe active hormonal form of vitamin D3. Induces cell differentiation and prevents

proliferation of cancer cells. Along with dietary calcium, reduces the risk of colon cancer.

It was shown recently to be a preventive factor in the metastasis of lung cancer.

Garland C, Garland FC. Int J Epidemiol. 9:227-231 (1980).

Mehta RG, Moriarty RM, Mehta RR et al. J Natl Cancer Inst. 89:212-21(1997).

Nahagawa K, Kawauna A, Keto S et al. Carcinogenesis. 26:429-440 (2005).

C0147 Calcium Folinate, Pentahydrate 100 mg5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, Leucovorin 500 mgC20H21CaN7O7

.5H2O FW 601.59 [6035-45-6] 1 gWhen administered after methotrexate. It supplies cells with tetrahydrofolate and diminishes

methotrexate toxicity without abolishing the antitumor effect.

Stoller RG, Hande KR. Jacobs SA et al. New Eng. J. Med. 297:630-634 (1977).

C0344 Calphostin C 100 µgC46H38O13 FW 790.76 [121263-19-2]A highly specific inhibitor of PKC. Acts as at the regulatory domain. Induces

apoptosis in HL-60 human promyelocytic leukemia cells and human glioblastoma cells.

Jarvis, W.D., Yurner, A.J., Povirk, L.F., et al. Cancer Res. 54:1707-14 (1994).

Begemann, M., Kashimawo, S.A., Lunn, R.M., et al. Anticancer Res. 18:3139-52 (1998).

C0346 Calyculin A 10 µgC50H81N4O15P FW 1009.17 [101932-71-2] 50 µgProtien phosphatase inhibitor. Induces apoptosis in epithelial tumor cell line,

HeLa and KB, and human breast tumor cells.

Von Zezschwitz C, Vorwerk H, Tergau F, Steinfelder HJ. FEBS Lett. 413:147-51 (1997).

Kiguchi K, Glesne D, Chubb CH et al. Cell Growth Differ. 5:995-1004 (1994).

C0150 Camptothecin 25 mgC20H16N2O4 FW 348.35 m.p. 276-278oC [7689-03-4] 100 mgA cytotoxic antitumor agent, that acts by inhibition of topoisomerase I. 250 mgHertzberg RP, Caranfa MJ, Hecht SM. Biochemistry. 28:4629-4638 (1989).

C0152 Camptothecin, 9-amino 10 mgC20H17N3O4 FW 363.37 [91421-43-1] 25 mgAn active derivative of camptothecin, which belongs to the general group of 50 mgchemotherapy drugs called topoisomerase inhibitors.

Takimoto, C.H.; Thomas, R. Ann. N.Y. Acad. Sci. 922: 224-36 (2000).

HH

H

HO

OH

OH

N

N

N

HN

H

OO

H

H2N

HN

NH

O

OO

Ca

O

.5H2O

O

O

O

O

O

O

O

OH O

OH

OH

O

O

O

H3CO NH

N

O

O

O

OHO

OHO

OHOH

OHN

OCH3C

P

N

OH

O

HO

CH3H3C

Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2(Disulfide Bridge (Cys2-Cys7)

H-Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (Disulfide Bridge Cys2-Cys7)

H-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2

N

N

O

O

OOH

N

N

O

O

O

CH3CH2

OH

NH2


C0154 Camptothecin, 7-ethyl-10-hydroxy 10 mgSN38 50 mgC22H20N2O5 FW 392.40 [86639-52-3] 100 mgThe active metablite of irinotecan that is a topoisomerase I inhibitor.

Kaneda N, Nagata H, Furuta T, Yokokura T. Cancer Research. 50:1715-20 (1990).

C0155 Camptothecin, 10-hydroxy 25 mgC20H16N2O5 FW 364.35 [64439-81-2] 100 mg

C0156 Camptothecin, 9-nitro-20(S) 25 mgC20H19N3O6 FW 393.35 [91421-42-0] 50 mgActive derivative of camptothecin. Induces apoptosis and inhibits HIV. 100 mgChatterjee D. Schmitz I. Krueger A et al. Cancer Res. 61:7148-54 (2001).

Hung CL. Doniger J. Palini A et al. J Med Virology. 64:238-44 (2001).

C0253 Candesartan 100 mgC24H20N6O3 FW 440.45 [139481-59-7 ] 250 mgAn angiotenin II receptor antagonist used to treat hypertension 1 gKumagai, H. Therapeutic Research (2003), 24(11), 2036-2043.

C0254 Candesartan Celexetil Ester 100 mgC33H34N6O6 FW 610.66 [145040-37-5] 250 mgCandesartan 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester 1 gAn angiotenin II receptor antagonist used to treat hypertension

Kumagai, H. Therapeutic Research (2003), 24(11), 2036-2043.

Canrenoic acid potassium salt (See Potassium Canrenoate)

C0252 Canertinib Dihydrochloride 25 mgC24H23ClFN5O3

. 2HCl FW 558.86 [289499-45-2] 100 mgA water-soluble, EGFR tyrosine kinase inhibitor. It induces ErbB-independent 250 mgapoptosis in human leukemia (HL-60 and U937) cells.

Smaill JB, Palmer BD, Rewcastle GW, et al J. Med. Chem. 42:1803-1815 (1999).

Trinks C, Djerf EA, Hallbeck AL, et al Biochem Biophys res. Commun. 393:6-10 (2010).

C0160 Canrenone 1 gC22H28O3 FW 416.13 [976-71-6] 5 gActive metabolite of spironolactone. Inhibits aldosterone biosynthesis. 25 gBlocker of ouabin effects.

Cittadini et al. Cardiovasc Res. 58:555-64 (2003).

Balzan S, Nicolini G, Bellitto L et al. J Cardiovasc Pharmacol. 42:32-6 (2003).

Datta P, Dasgupta A. Ther Drug Monit. 25:478-82 (2003).

C0255 Cantharidin 25 mgC10H12O4 FW 196.20 [56-25-7] 100 mgA terpenoid from blister beetles, exhibits anticancer activity is not suitable for cancer 500 mgtherapy because of its high cytotoxicity in vitro.

Yeh CB, Su CJ, Hwang JM, Chou MC. Eur J Med Chem. Sep;45(9):3981-5 (2010).

C0168 Canthaxanthin 5 gC40H52O2 FW 564.84 [514-78-3] 10 gAn antioxidant that suppresses cell proliferation in oral cancer cells. 25 gTanak T, Makita H, Ohnishi M et al. Cancer Res. 55:4059-4064 (1995).

O

O

O

O

HH

HCH3

CH3

O

N

N

N

NN

HN

O

O OOO

O

O

O

O

O

N

N

O

O

OOH

HO

CH2CH3

N

N

O

O

OOH

HO

N

N

O

O

OH2CH3C

OH

NO2

N

N

O OH

O

H3C

NN

N

NH


C0162 Capecitabine 250 mg C15H22FN3O6 FW 359..35 [154361-50-9] 1 gA chemotherapeutic agent used in the treatment of metastatic breast and 5 gcolorectal cancers. A prodrug that is enzymatically converted to 5-fluorouracil in

the tumor where it inhibits DNA synthesis and slows growth of tumor tissue

Fischer, D. S. The Cancer Chemotherapy Handbook (6th Edition). Mosby.

C0260 Capsanthin 50 gC40H56O3 FW 584.87 [465-42-9] 100 gA natural carotenoid isolated from red paprika. It has chemopreventive and anti-tumor activity.

Nishino H et al. Cancer Metastasis Rev. 21:257-64 (2002).

Perez-Galvez A, Martin HD, Sies H, Stahl W. Br J Nutr. 89:787-93 (2003).

C0266 Capsaicin, natural (See page 5 for more information) 100 mgC18H27NO3 FW 305.41 [404-86-4] 250 mgCapsaicin, ≥65%, dihydrocapsaicin, ~20%, nordihydrocapsaicin, ~4 %. 1 g

C0261 Captopril 1 gC9H15NO3S FW 217.29 m.p. 103-104oC [62571-86-2] 5 gThe first orally active inhibitor of angiotensin-converting enzyme. A 25 greversible and competitive inhibitor of LTA4 hydrolase.

Kostis J. Am Heart J. 116: 1591 (1988).

Orning L et al. J Biol Chem. 266:16507 (1991).

C0268 Carbadox 25 gC11H10N4O4 FW 262.22 [6804-07-5] 100 gBroad spectrum antimicrobial agent.

Prapasarakul N, Ochi K, Adachi Y . J Vet Med Sci. 65:1275-80 (2003).

Drumev D. Vet Med Nauki. 18:10-25 (1981).

C0270 Carbamazepine 1 gC15H12N2O FW 236.27 [298-45-4] 5 gCytochrome P450 3A4 inducing anti-epileptic drug. It increases metabolism of 25 g CPT11 and Paclitaxel, and many tyrosine kinase inhibitors. Used in the treatment

of shooting neuralgic pain attacks.

van den Bent MJ. Eur J Cancer. 39:2114-20 (2003).

Lindner V, Deuschl G. Schmerz.18:53-60 (2004).

C0169 Carbenoxolone disodium 1 gC34H48Na2O7 FW 614.70 m.p. 291-2940C [7421-40-1] 5 gA triterpenoid chemopreventive agent. 25 gRao CV, Rivenson A, Kelloff GJ, Reddy BS. Anticancer Res. 15:1199-1204 (1995).

C0170 N-(4-Carbethoxyphenyl)retinamide 100 mgC29H37NO3 FW 447.62 [53839-71-7] 500 mgA derivative of the chemopreventive agent fenretinide. 1 g

C0175 Carbetocin Acetate Please InquireC45H69N11O12S FW 988.17

C0367 S-(-)-Carbidopa monohydrate 25 mgC10H14N2O4

. H2O FW 244.24 [38821-49-7] 100 mgCarbidopa inhibits aromatic-L-amino-acid decarboxylase (DOPA Decarboxylase or

DDC),an enzyme important in the biosynthesis of L-tryptophan to serotonin and in the

biosynthesis of L-DOPA to Dopamine (DA).

Gilbert JA, Frederick LM, Ames MM Clinical cancer researc 6 (11): 4365–72 (2000).

N

CO2H

CCH2SH

H3C

H

C

O

CO2CH2CH3

O

NH

N

N

N

HN OCH3

O

O

O

N

O NH2

Butyryl-Tyr(Me)-Ile-Gln-Asn-

Cys-Pro-Leu-Gly-NH2 (Sulfide

bond: Butyryl-4-yl and Cys)

N

NO

F

HN

O

O

O

HO OH

CH3

H

O H

H

CH3

CH3

CH3

O

HO2C

O

H3C CH3

CO2HH3C

HO

OH

OH

O

NH

H2O

NH2

NH

CH3

CH3

O

OH

OH3C

HO

O

OH


C0172 Carbimazole 1 gC7H10N2O2S FW 186.23 [22232-54-8] 5 gThyroid inhibitor. 10 gWise PH, Marion M, Tain R. Clin Endocrinol (Oxf)10:655-64 (1979).

C0171 Carboplatin (See page 4 for more information) 25 mgcis-Diammine[1,1-cyclobutane dicarboxylato] platinum 100 mgC6H12N2O4Pt FW 371.25 [41575-94-4] 250 mgAn analogue of cisplatin. It is an antitumor agent.

Smith IE et al. Cancer Treat. Rep 69:43 (1985).

Calvert AH et al. Cancer Chemother. Pharmacol. 9:140 (1982).

C0174 Carmofur 1 gC11H16FN3O3 FW 257.26 [61422-45-5] 5 gOrally active cytostatic derivative of fluorouracil.

Noda T, Kosakai H, Tsujimura, K et al. Gan Kagaki Ryoho 10:1972-1979 (1983).

Grohn P, Heinonen E, Kumpulainen E, et al. Am. J. Clin. Oncology. 13:477-179 (1990).

C0173 Carmustine (See pages 4 and 26 for more information) 25 mgC5H9Cl2N3O2 FW 214.05 [154-93-8] 100 mgAlso known as BCNU. An antitumor alkylating agent used in the treatment of malignant glioma.

Engelhard, HH. Surg Neuraol 53:458-64 (2000).

Carter SK, Schabel FM Jr, Broder LE, Johnston TP. Adv. Cancer Res 16:273-332 (1972).

C0262 L-Carnitine 1 gC7H15NO3 FW 161.20 [541-15-1] 5 gA neuromodulator and antiaging agent. Plays a vital role in fatty acid transport 25 g across the mitochondrial membrane. Prevents neurotoxicity caused by drug abuse.

Juliet PA, et al. A Biol Sci Med Sci. 58:970-4 (2003).

C0263 L-Carnitine HCl 1 gC7H15NO3HCl FW 197.66 [66454-46-1] 5 gSee L-Carnithine 25 g

C0264 L-Carnitine tartrate 1 g2(C7H15NO3)2

.C4H6O6 FW 472.49 [36687-82-8] 5 gThe preferred forms are L-carnitine (68%) and natural L-tartaric acid (32%). 25 g

C0265 Carnosic acid, 90 % 25 mgC20H28O4 FW 332.43 [3650-09-7] 50 mgAntioxidant isolated from Rosemary. Has shown chemoprotective effects.

Richheimer, SL, Bernart M W, King Greg A et al. JAOCS 73:507-14 (1996).

Danilenko M, Wan X, Studzinski GP. J Natl Cancer Inst. 93:1224-33 (2001).

Offord EA, Mace K, Avanti O, Pfeifer AM. Cancer Letters. 114:275-81 (1997).

C0267 Carnosol 1 mgC20H26O4 FW 330.42 [5957-80-2] 5 mgA naturally occurring phytopolyphenol found in Rosemary that functions as an

antioxidant, antimicrobial, and anticarcinogen. It has been shown to inhibit the

induction of COX-2 by blocking PKC signaling.

Subbaramaiah K, Cole PA, Dannenberg AJ. Cancer Res. 62:2522-30 (2002).

Lo AH, Liang YC, Lin-Shiau SY et al. Carcinogenesis. 23:983-91 (2002).

O

Pt

O

O

O

NH3

NH3

N N O CH3

H3C

S O

NH

N

F

OO

NH

CH3

O

OOCN

CH3

CH3

CH3

OH

N

O

O

HO H O

OH

OH

O

O

O

N

O

O

HO H

HCl

ClN

NHN

O

O

Cl

OH

HO

CO

O

H

C

HO

OH

OHO


C0269 β-Carotene 1 gC40H56 FW 536.87 [7235-40-7] 5 gAn antioxidant known to inhibit carcinogenisis. Found to decrease

levels of IQ-DNA adducts in animal hepatocytes.

Rousseau EJ, Davison AJ. Free Radic Biol Med. 13:407-433 (1992).

Uehara N, Iwahori Y, Asamoto M et al. Jpn J Cancer Res. 87:342-348 (1996).

C0351 Carprofen (See page 17 for more information) 1 gC15H12ClNO2 FW 273.71 [52263-47-5] 5 gIs a non-steroidal anti-inflammatory drug whose mechanism of action is dependent

upon inhibiting the production of cox-2 and other sources of prostaglandins

Leblanc, Y. Bioorganic & Medicinal Chemistry Letters (1995), 5(18), 2123-8.

Mancini, J. A. J. Biological Chemistry (1995), 270(49), 29372-7.

Greig, G. M. Molecular Pharmacology (1997), 52(5), 829-838.

C0370 Carrageenan Sodium 5 g[9000-07-1] 25 gStructural polysaccharide of the red sea weed.

Used to induce inflammation in experimental animals.

C0365 Carvedilol 1 gC24H26N2O4 FW 406.47 [72956-09-3] 5 gA non-selective b1-adrenergic antagonist. It protects against induced 10 g mitochondrial cardiomyopathy.

Flordellis CS, Goumenos D, Kourounis G et al. J. Curr Top Med Chem. 4:487-98 (2004).

Santos DL, Moreno AJ, Leino RL et al. Toxicol Appl Pharmacol. 185:218-27 (2002).

C0368 Carveol 5 gC10H16O FW 152.23 [99-48-9] 25 gA terpene that inhibits mammary carcinogenesis.

Crowell PL, Keenan WS et al. Carcinogenesis. 13:1261-1264 (1992).

C0372 Casein Kinase 2 Assay Kit 1 mgC45H73N19O24 FW 1264.2 2 mg

5 mg

C0374 β-Casomorphin, human 5 mgC44H61N7O11 FW 864.02 10 mg

25 mg

C0375 Caspase 3, Substrate, Colorimetric 1 mgC26H34N6O13 FW 638.6 2 mg

5 mg

C0275 Castanospermine 10 mgC8H15NO4 FW 189.21 [79831-76-8] 50 mgA plant alkyloid which is a potent inhibitor of alpha and beta glucosidase 100 mgactivity in fibroblast extracts. It has also been known to inhibit the glycoprotein

processing cycle and exhibits strong anti-viral properties as well as preventing angiogenesis.

Vyavahare V. P. J. medicinal chemistry (2007), 50(22), 5519-23.

Benltifa M. Bioorganic & medicinal chemistry letters (2008), 18(9), 2805-8.

Gloster, T. M. J. American Chemical Society (2007), 129(8), 2345-2354

HO

O

O

CH2

OH

OOHO

O3SO

O

H-Arg-Arg-Arg-Asp-Asp-Asp-

Ser-Asp-Asp-Asp-OH

H-Tyr-Pro-Phe-Val-Glu-Pro-

Ile-OH

Ac-Asp-Glu-Val-Asp-pNA

NHO

OHH

HO

OH

NH

O NH

O

H3CO

OH

HN

CH3

COOH

Cl


C0379 Catch-Relaxing Peptide (CARP) 1 mgC36H67N11O7S2 FW 830.13 2 mg

5 mg

C0277 Catechins, 90 % (See Green Tea Polyphenols)

C0278 Catechin, 99 % 1 mgC15H14O6 FW 290.27 [154-23-4] 5 mgA natural flavonoid that has chemopreventive and antitumor properties.

Azuine M A, Bhide SV. Journal of Ethnopharmaclogy. 44:211-7 (1994).

Bhattacharyya J, Biswas S, Datta AG. Curr Med Chem.11:359-68 (2004).

C0376 Catharanthine base (See page 8 for more information) 25 mgC21H24N2O2 FW 336.43 [2468-21-5] 100 mgIt is one of the many alkaloids present in Catharanthus roseus. Can be used as a 500 mg starting material for the synthesis of the anti-tumor drugs vinblastine and vincristine.

It is less active as an inhibitor of tubulin self-assembly into microtubules

than the latter two compounds.

Uniyal GC, Bala S, Mathur Ak et al. Phytochem Anal. 12:206-210 (2001).

Prakash V, Timasheff SN. Biochemistry. 30:873-880 (1991).

Pennanen S, Huhtikangas A. Photochem Photobiol. 51:515-518 (1990).

C0377 Catharanthine sulfate (See page 8 for more information) 25 mgC21H24N2O2

.H2S04 FW 434.51 100 mgCatharanthine is a precursor of vinblastine-type alkaloids. It was found to 500 mghave antitumor activity.

Zhao J, Hu Q, Guo YQ, Zhu WH. Appl Microbiol Biotechnol. 55:693-8 (2001).

C0378 Catharanthine tartrate (See page 8 for more information) 25 mgC21H24N2O2

.C4H6O6 FW 486.52 [2468-21-5] 100 mg500 mg

C0476 CB-TH 1 mgC138H230N46O34S4 FW 3205.9 2 mgA hybrid peptide containing the N-terminal residue of cecropin B (CB) and 5 mgC-terminal end of thanatin (TH) that shows antimicrobial activity.

Hongbiao,W.; Baolong, N.; Mengkui, X.; Lihua, H.; Weifeng, S.; Zhiqi, M. J. Pept. Res. 66:382-6 (2005).

CCNU (See Lomustine)

C1600 CEA (605-613) 1 mgC43H69N11O14 FW 964.09 2 mg

5 mg

C1601 CEA (605-613) analogue 1 mgC43H68N10O15 FW 965.08 2 mg

5 mg

C1609 Cecropin B 1 mgC176H305N52O41S FW 3834.76 [80451-05-4] 2 mgAntibacterial peptide isolated from pig intestine and moths. 5 mgLee, J.-Y., et al. Proc. Nat. Acad. Sci. USA 86:9159-9162 (1989).

OHO

OH

OH

OH

OH

NH

N

CH3

OCH3O

NH

N

CH3

OCH3O

.C4H6O6

NH

N

CH3

OCH3O

.H2SO4

H-Ala-Met-Pro-Met-Leu-Arg-

Leu-NH2

Arg-Trp-Lys-Ile-Phe-Lys-Lys-

Ile-Glu-Lys-Met-Gly-Gly-Ser-

Tyr-Cys-Asn-Arg-Arg-Thr-Gly-

Lys-Cys-Gln-Arg-Met

Tyr-Leu-Ser-Gly-Ala-Asn-Leu-

Asn-Leu

Tyr-Leu-Ser-Gly-Ala-Asp-Leu-

Asn-Leu

H-Lys-Trp-Lys-Val-Phe-Lys-

Lys-Ile-Glu-Lys-Met-Gly-Arg-

Asn-Ile-Arg-Asn-Gly-Ile-Val-

Lys-Ala-Gly-Pro-Ala-Ile-Ala-

Val-Leu-Gly-Glu-Ala-Lys-Ala-

Leu-NH2


C1613 Cediranib (See page 29 for more information) 25 mgC25H27FN4O3 FW 450.51 [288383-20-0] 100 mgCediranib is a potent antitumor and antiangiogenic compound. It inhibits vascular 250 mgendotheial growth factor(VEGF) receptor tyrosine kinases.

Wedge SR, Kendrew J, Hennequin LF, et al Cancer Res. 65:4389-4400 (2005).

Medinger M, Esser N, Zirrgiebel U, et al. Anticancer Res. 29:065-76 (2009).

C1619 CEF3 1 mgC42H74N10O12 FW 911.12 2 mg

5 mg

C1621 CEF4 1 mgC53H93N15O13 FW 1148.42 2 mg

5 mg

C1622 CEF6 1 mgC48H78N10O14S FW 1051.28 2 mg

5 mg

C1623 CEF10 1 mgC39H71N9O11S FW 906.2 2 mg

5 mg

C1627 Cefaclor Monohydrate 500 mgC15H13ClN3O4S.H2O FW 385.83 [70356-03-5] 1 gAntimicrobial agent. It has a broad spectrum of activity against the most 5 gprevalent gram-positive and gram-negative respiratory tract pathogens.

Stock I, Sherwood KJ, Wiedemann B. Diagn Microbiol Infect Dis. 48:5-15 (2004).

Guay DR. Clin Ther. 24:473-8 9 (2002).

Meyers BR. Clin Ther. 22:154-66 (2000).

C1629 Cefoperazone Acid 1 gC25H27N9O8S2 FW 645.67 [62893-19-0] 5 gAntimicrobial agent that possesses potent beta-lactamase-inhibitory properties.

Jamieson CE, Lambert PA, Simpson IN. Antimicrob Agents Chemother. 47:1652-7 (2003).

Cuchural GJ Jr. Pharmacotherapy. 11(2 ( Pt 2)):51S-55S (1991).

C1630 Cefoperazone Sodium 1 gC25H26N9NaO8S2 FW 667.65 [62893-20-3] 5 gAntimicrobial agent. Used for prevention of postoperative infection. It inhibits

the inactivation of alpha(1)-antitrypsin.

Uchiyama K, Kawai M, Onishi H et al. Dig Dis Sci. 48:1955-9 (2003).

Dallegri F, Dapino P, Arduino N et al. Antimicrob Agents Chemother. 43:2307-10 (1999).

C1632 Cefotaxime Acid 500 mgC16H17N5O7S2 FW 455.47 [63527-52-6] 1 gAntimicrobial agent. It is effective against postoperative complications in 5 gsurgical treatment of pulmonary, tracheal and mediastinal tumors.

Petrova MV, Korniak AV, Krasnova TE. Anesteziol Reanimatol. 5:58-60 (2001).

Kern WV, Cometta A, De Bock R et al. N Engl J Med. 341:312-8 (1999).

N

S

NH

O

COOH

HH

O

HNN

S

N N

N

N

CH3

O

N

O

O

H3C

OH

N

S

NH

O

COONa

HH

O

HNN

S

N N

N

N

CH3

O

N

O

O

H3C

OH

N

S

NH

O

COOH

HH

O

O CH3

O

S

NH2N

N

OCH3

H-Ser-Ile-Ile-Pro-Ser-Gly-Pro-

Leu-Lys-OH

H-Arg-Val-Leu-Ser-Phe-Ile-Lys-

Gly-Thr-Lys-OH

H-Leu-Pro-Phe-Asp-Lys-Thr-

Thr-Val-Met-OH

H-Cys-Leu-Gly-Gly-Leu-Leu-

Thr-Met-Val-OH

N

SNH

O

COOH

Cl

HHO

NH2

H2O


C1633 Cefotaxime Sodium 500 mgC16H16N5NaO7S2 FW 477.45 [64485-93-4] 1 gAntimicrobial agent. It is used for prevention of postoperative infection in 5 g patients who undergo head and neck cancer surgery with major flap reconstruction.

Bhathena HM, Kavarana NM. Acta Chir Plast. 40:36-40 (1998).

C1635 Ceftazidime 1 gC22H22N6O7S2 FW 546.58 [72558-82-8] 5 gAntimicrobial agent. It is used for treating febrile neutropenia in patients with cancer.

Hung KC, Chiu HH, Tseng YC et al. J Microbiol Immunol Infect. 36:254-9 (2003).

Mustafa MM, Carlson L, Tkaczewski I et al. Pediatr Infect Dis J. 20:362-9 (2001).

C1620 Ceftiofur Hydrochloride 500 mgC19H17N5O7S3

.HCl FW 560.02 [104010-37-9] 1 gAn antibiotic of the cephalosporin type. It has activity against most gram 5 gpositive and gram negative bacteria.

Zioga, A. Journal of Antimicrobial Chemotherapy (2008), 61(6), 1389-1390.

Diarrassouba, F. Journal of Food Protection (2007), 70(6), 1316-1327.

Zioga, A. Journal of Antimicrobial Chemotherapy (2008), 61(6), 1389-1390.

C1637 Ceftriaxone sodium 250 mgC18H16N8O7S3Na2 FW 598.54 [104376-79-6] 500 mgA broad-spectrum antimicrobial agent. It is used also in the treatment of febrile 1 g granulocytopenic children with cancer.

Gorschluter M et al. Support Care Cancer. 11:362-70 (2003).

C1624 Cefuroxime Sodium Salt 1 gC16H15N4NaO8S FW 446.37 [56238-63-2] 5 gA second-generation cephalosporin antibiotic.

Harvard CWH, Fernando A, Bannister B, et al. J. Antimicrob. Chemother. 8 (5): 401-408 (1981).

C1648 α-Cembrenediol 10 mgC20H34O2 FW 306.48 [57605-80-8]A compound found in cigarette smoke condensate and were shown to inhibit tumor promotion by

tetradecanoylphorbol acetate by inhibiting the early antigen of the Epstein-Bar virus.

Degradation products are responsible for tobacco flavors.

Saito, Y., Tsujino, Y., Kaneko, H., Yoshida, D., Mizusaki, S. Agric. Biol. Chem. 51:941 (1987).

Crombie, L.; McNamara, D.; Firth, D. F.; Smith, S.; Bevana, P. C. Phytochemistry 27:1685-1693 (1988).

C1649 β-Cembrenediol 10 mgC20H34O2 FW 306.48 [57605-81-9]A compound found in cigarette smoke condensate and were shown to inhibit tumor promotion by





C1650 β-Cembrenediol methyl ether 10 mgC21H36O2 FW 320.51

A compound found in cigarette smoke condensate and were shown to inhibit tumor promotion by





N

S

NH

O

COONa

HH

O

O CH3

O

S

NH2N

N

OCH3

N

S

NH

O

COO

HH

O

N

S

NH2N

N

O

CH3

CH3

HOOC

N

S

NH

O

COOH

HH

O

S

S

NH2N

N

OCH3

N

NH

N

CH3

O

O

CH3

HO

OH

CH3H3C

H3C

CH3

CH3

HO

OH

CH3H3C

H3C

CH3

N

S

O O

O NH2

O

O

HH

HN

O

NO

O

Na

S

NS

O

O

O

NH

H

HO O

O

N

O

SN

NH2

HCl


C1718 Cepharanthine, 98% (See page 10 for more information) 100 mgC37H38N2O6 FW 606.71 [481-49-2] m.p. 145-1550C 500 mgCepharanthine is a biscoclaurine alkaloid isolated from Stephania cepharantha 1 gHayata. It has anti-inflammatory, anti-allergic and immunomodulatory activity

Kondo Y, Takano F, Hojo H. Biochem. Pharmacol. 46:1887-1892 (1993).

Okamoto M, Okamoto T, Baba M. Antimicrob Agents Chemother. 43:492-497 (1999).

C1867 Ceramide-C16 5 mgC16 (C34H67NO3) FW 537.90 [24696-26-2] 25 mgA constituent of arthropod spingolipids. Ceramides are important intracellular second messengers

that play a role in the regulation of cell growth, differentiation, and programmed cell death.

Fillet M, Bentires-Alj M, Deregowski V, Greimers R et al. Biochem Pharmacol. 65:1633-42 (2003).

Aschrafi A, Franzen R, Shabahang S et al. Acta. 1634:30-9 (2003).

C1868 Cerebellin 1 mgC69H113N23O23 FW 1632.81 [94071-26-8] 2 mgA cerebellum peptide used as a Purkinje cell marker for monitoring 5 mg neurodevelopment.

Slemmon JR, Danho W, Hempstead JL, Morgan JI. Proc Natl Acad Sci U S A. 82: 7145-8 (1985).

C1668 Cerivastatin Sodium (See page 26 for more information) 10 mg

C26H33FNNaO5 FW 481.53 [143201-11-0] 25 mgA compound used to decrease LDL cholesterol levels.

DrugBank.http://www.drugbank.com(accessed Aug. 2006).

C1869 Cerulenin 1 mgC12H17NO3 FW 223.27 [17397-89-6] 5 mgNoncompetitive inhibitor of fatty acid synthase. It induces apoptosis in 10 mg tumor cell lines.

Pizer ES, Jakisch C, Wood FD et al. Cancer Res. 56:2745-7 (1996).

Furuya, Y., Akimoto, S., Yasuda, K., Ito, H. Anticancer Res. 17:4589-93 (1997).

C1876 Cetirizine Dihydrochloride 5gC21H25ClN2O3

. 2HCl FW 461.82 [83881-52-1] 10 g

A carboxylated metabolite of hydroxyzine that has been shown to block the influx of 25 geosinophils into the site of antigen-stimulated skin blisters.

Snyder SH, Snowman AM. Ann Allergy. 59(6 Pt 2):4-8 (1987).

Naclerio RM. Allergy Proc. 12:187-191 (1991).

C1878 Cetrimide 50 gHexadecyltrimethylammonium bromide 250 gC19H42BrN FW 364.45 [57-09-0]A mixture of chiefly tetradecyltrimethylammonium bromide together with smaller

amounts of dodecyltrimethylammonium bromide and cetrimonium bromide.

C1879 Cetrorelix Acetate Please inquireC70H92N17O14 FW 1431.06 [130143-01-0]

Injectable cetrorelix acetate is a synthetic decapeptide with gonadotropin-releasing hormone

(GnRH) antagonistic activity. Cetrorelix acetate is an analogue of native GnRH with substitutions

of amino acids at positions 1, 2, 3, 6, and 10.

CH2

OCH3

O

N

CH3O

CH3

H

CH2N

O

O

O

CH3

H

H3CNH2

O O

OH H

CH3(CH2)12 OH

HN (CH2)14CH3

O

OH

H-Ser-Gly-Ser-Ala-Lys-Val-

Ala-Phe-Ser-Ala-Ile-Arg-Ser-

Thr-Asn-His-OH

Ac-3-(2-naphthyl)-D-Ala-4Chloro-

D-Phe-3(3-pyridyl)-D-Ala-Ser-

Tyr-D-Cit-Leu-Arg-Pro-D-Ala-OH

H3C

N

H3C

CH3

CH3

Br

N

F

HO OHH H

O O

O

Na+

N

N

O

OH

O

Cl

2HCl


C2468 β-CGRP, human 1 mgC162H267N51O48S3 FW 3793.38 [98824-26-1]

C2800 Chalcone 97% (See page 14 for more information) 25 gtrans-Benzylideneacetophenone 100 gC15H12O FW 208.26 m.p. 550C [94-41-7] 500 gAn open chain flavonoid. Inhibits lung and forestomach carcinogenesis.

Wattenberg, LW, Coccia, JB, Galbraith, AR. Cancer Lett. 83:165-169 (1994).

C2803 Chartreusin 5 mgLambdamycin 25 mgC32H32O14 FW 640.6 [6377-18-0]An antitumor antibiotic from Streptomyces chartreusis. It inhibits topoisomerase II and

has been shown to inhibit DNA and RNA synthesis in certain models.

Obrig T, Frenkel GD. Res Commun Chem Path. 34:173-6 (1981).

Lorico A, Long BH. Eur J Cancer. 29A:1985-91 (1993).

C2816 Cheirolin, 98% 25 mgC5H9NO2S2 FW 179.26 [505-34-0] 50 mg

100 mg500 mg

C2818 Chelerythrine Chloride 1 mgC21H18ClNO4 FW 383.82 [3895-32-9] 5 mgA natural benzophenanthridine alkaloid. Inhibits protein kinase C and induces

apoptosis in HL-60 human promyelocytic leukemia cells.

Jarvis WD, Turner AJ, Povirk LF. Cancer Res. 54:1707-14 (1994).

Anthony ML, Zhao M, Brindle KM. J Biol Chem. 274:19686-92 (1999).

C2916 Chenodeoxycholic Acid 1 gC24H40O4 FW 392.57 [474-25-9] 5 gBile acid that induces apoptosis via a protein kinase C-dependent signaling 25 gpathway.

Matinez, J.D., Stratagoules, E.D., LaRue, J.M., et al. Nutr. Cancer 31:111-8 (1998).

C2946 Chlorambucil 100 mgC14H19Cl2NO2 FW 304.21 [305-03-3] 500 mgA nitrogen mustard alkylating agent commonly used to treat lymphocytic 1 gleukemia. It induces apoptosis in chronic lymphocytic leukemia cells. 10 gBegleiter A, Mowat M, Israels LG, Johnston JB. Leuk Lymphoma. 23:187-201 (1996).

King D, Pringle JH, Hutchinson M, Cohen GM. Leukemia. 12:1553-60 (1998).

C2844 Chloramphenicol 5 gC11H12Cl2N2O5 FW 323.13 m.p. 150.5-151.50C [56-75-7] 10 gA broad spectrum antibiotic. It induces apoptosis in the developing brain. 50 gGuimaraes CA, Linden R. Neuropharmacology. 39:1673-9 (2000).

C11H12Cl2N2O5 F.W. 323.13, m.p. 150.5-151.50C [56-75-7]

C2845 Chloramphenicol Levo 5 gC11H12Cl2N2O5 FW 323.13 m.p. 150.5-151.50C [56-75-7] 10 gOptically active chloramphenicol. 50 g

O

NO2

HOCH

HCNHCCHCl2

CH2OH

O

O

O

+N

OCH3

OCH3H3CCl

-

H3C

H

CH3

H3C

COOH

HO OH

N CH2CH2CH2COOH

ClCH2CH2

ClCH2CH2

O

O

O

O CH3

OH

O

O

O

CH3

OH

OH

OH

OMe

OH

CH3

O

NO2

HOCH

HCNHCCHCl2

CH2OH

O

Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-

Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-

Ser-Arg-Ser-Gly-Gly-Met-Val-Lys-

Ser-Asn-Phe-Val-Pro-Thr-Asn-

Val-Gly-Ser-Lys-Ala-Phe-NH2

(Disulfide bridge Cys2-Cys7)

S N C S

O

O


C2847 Chlormadinone Acetate 1 gC23H29ClO4 FW 404.93 [302-22-7] 5 gProgestogen with questionable antiandrogenic activity. It suppresses ACTH

hypersecretion and lowers plasma testosterone levels.

Kageyama Y, Kitahara S, Tsukamoto T et al. Endocr J. 42:505-8 (1995).

Labrie F, DuPont A, Belanger A et al. Cancer Metastasis Rev. 6:615-36 (1987).

C2942 Chlormethine HCl 5 gMechlorethamine HCl 10 gC5H11Cl2N.ClH FW 192.51 [55-86-7] 25 gA chemotherapeutic agent showing antitumor activity attributed to its ability to cross-link the

twin strands of DNA. A one-hour exposure caused a transient late S/G2 cell cycle arrest in

both the HL-60 cell line and the Colo 320HSR human colon cancer cell line.

Xie J, Shults K, Flye L et al. J Cell Biochem. 95:339-351 (2005).

Balcome S, Park S, Quirk Dorr DR et al. Chem Res Toxicol. 17:950-962 (2004).

C2948 Chloroadenosine 5 mgC10H12ClN5O4 FW 301.69 [146-77-0] 10 mgAdenosine receptor site agonist that induces apoptosis. 50 mgSzondy Z. Biochem J. 304:877-85 (1994).

C2944 Chlorogenic Acid 100 mgC16H18O9 FW 354.31 m.p. 209-209oC (dec.) [327-97-9] 250 mgA chemopreventive analogue of caffeic acid. 1 gTanaka T, Kojima T, Kawamori T et al. Carcinogenesis. 14:1321-1325 (1993).

C2943 Chlorogenic Acid (from Eucommia bark) 250 mgC16H18O9 FW 354.31 [327-97-9] 1 gA chemopreventive analog of caffeic acid.

Tanaka, T., Kojima, T., Kawamori, T., et.al. Carcinogenesis. 4:1321-1325 (1993).

C2945 Chlorophyllin 5 gSodium-Copper Salt 25 gFW 618.97 [15611-43-5] 100 gSodium salt of copper complex have a water soluble salt of chlorophyllwhich inhibits activation and degradation of electrophyllic intermediates.Tachino H, Guo D, Dashwood WM et al. Mutat Res. 308:191-203 (1994).

C2950 Chloroquine Phosphate 25 gC18H26ClN3

.2H3PO4 FW 515.87 [50-63-5] 50 gAntimalarial agent that has been found to have a distinct affinity for melanin. 100 gUsed in the treatment of malaria, arthritis, and Lupus.

Graves PR, Kwiek JJ, Fadden P, Ray R et al. Mol Pharmacol. 62:1364-72 (2002).

Ono C, Yamada M, Tanaka M. J Pharm Pharmcol. 55:1647-54 (2003).

C2949 Chlorpheniramine Maleate 5 gC16H19ClN2

.C4H4O4 FW 390.87 [113-92-8] 25 gAn antihistamine that has chemopreventive property. It inhibits carcinogen 100 gaberrant crypt foci. Inhibits ornithine decarboxylase induction in experimental

mammary tumors and in MCF-7 cells.

Medina MA, Garcia de Veas R et al. Breast Cancer Res Treat. 35:187-94 (1995).

Wargovich MJ, Jimenez A, McKee K et al. Carcinogenesis. 21:1149-55 (2000).

N

N

N

N

HOCH2

H

O

H

OH

H

OH

H

NH2

Cl

N

N

H3C

CH3

Cl

N

HNN CH3

CH3CH3

Cl

OH

OH

HO

O

O

OH

OH

HO2C

O

CH3

CH3

Cl

C

CH3

O

O CCH3

O

OH

OH

HO

CO2H

O

HO

HO

O

N N

Cu

N N

CH3CH CH2

H3C

CH2CH3

CH3H3C

CH2

CH2

CO2Na

CO2NaCOO

Na


C2947 Chlorpromazine Hydrochloride 10 g2-Chloro-10-(3-dimethylaminopropyl)phenothiazine 25 gC17H19Cl2N2S.HCl FW 355.3 [69-09-0] 100 gA neuroleptic or antipsychotic drug used to reduce hallucinations and delusions in

persons with mental illness. It also has chemopreventive property. Chlorpromazine

increases protein synthesis and chromatin susceptibility to enzymatic degradation.

Lonacar-Stevanoic H et al. Journal of environmental Pathology, toxicology & Oncology. 17:331-7 (1998).

Peak MJ, Pafaff M, Peraino C. Br J Cancer. 60:220-2 (1989).

C2951 Chlortetracycline Hydrochloride 5 gC22H23ClN2O8

.HCl FW 515.35 [64-72-2] 25 gAn antibiotic found to modulate TNF-alpha production. 100 gBall SJ, Warren EW. J Comp Pathol. 76:255-9 (1999).

Akunda JK, Johnson E, Ahrens FA et al. Comp Immunol Microb. 24:81-9 (2001).

C2956 Cholecalciferol 1 gVitamin D3 5 gC27H44O FW 384.64 [67-97-0] 25 gA form of vitamin D in fortified milk. Upon metabolic activation, induces cell differentiation and

prevents proliferation of cancer cells. Along with dietary calcium, reduces the risk of colon cancer.

Garland C, Garland FC. Int J Epidemiol. 9:227-231 (1980).

Mehta RG, Moriarty RM, Mehta RR et al. J Natl Cancer Inst. 89:212-218 (1997).

C2957 Cholesterol 5 gC27H46O FW 386.65 [57-88-5] 25 gMajor component of all biological membranes. It has been shown to inhibit 100 gbasal channel activity in the brain.

Crowley JJ, Treistman SN, Dopico AM. Mol Pharmacol. 64:365-72 (2003).

Peres C, Yart A, Perret B et al. FEBS Letters. 534:164-8 (2003).

C2963 Cholinesterase and Apoptosis Assay 25 TestsPh-F and SR-VAD-FMK 100 Tests

C2960 Chondroitin sulfate, bovine 5 gFW ~50,000 [9007-28-7] 25 gA naturocetic agent. Effective against osteoarthritis.

Reginster JY, Bruyere O, Lecart MP, Henrotin Y. Curr Opin Rheumatol. 15:651-5 (2003).

Hungerford DS, Jones LC. J Arthroplasty. 8(3 Suppl 1):5-9 (2003).

Walker-Bone K. Drugs Aging. 20:517-26 (2003).

C2961 Chondroitin sulfate, chicken 5 gFW ~50,000 25 gChondroitin sulfate is a naturocetic agent that is effective against osteoarthritis.

Reginster, J.Y., Bruyere, O., Lecart, M.P, and Heenrotin, Y. Curr Opin Rheumatol. 15:651-655 (2003).

Hungerford, D.S, Jones, L.C. J Arthroplasty. 8(3 Suppl 1):5-9 (2003).

C2965 Chromium Picolinate 5 gC18H12CrN3O6 FW 418.3 [14639-25-9] 25 gUsed to treat chromium deficiency. There is concern that chromium picolinate

causes DNA damage and mutation.

Diaz, M. L. Journal of Nutritional Biochemistry (2008), 19(1), 61-68.

Hynes, A. M. J. Canadian Journal of Veterinary Research (2007), 71(4), 249-255.

HH

H

HO

S

N

CH2CH2CH2N(CH3)2.HCl

Cl

O

OH

OH

COOH

RO O

HN

CH2OR

OO

CH3

O

O

Cl

OH O OH O

NH2

O

OHH H

NCH3HO

CH3H3C

OH

CH3

CH3

H3C

HH

HO

CH3 H

CH3 H

O

OH

OH

COOH

RO O

HN

CH2OR

O

O

CH3

O

O

N

O

Cr

O

N

O

O

N

O

O

3


C2969 Chromomycin A3 1 mgC57H82O26 FW 1183.2488 [7059-24-7] 5 mgThe major component of a streptomycete contaminant in a marine fungal culture 10 mgthat is an aureolic acid derivative that is a minor groove DNA-binding antibiotic.

Skarbek JD, Brady LR. Lloydia. 38:369-377 (1975).

Marx C, Berger C, Xu F et al. Assay Drug Dev Technol. 4:273-284 (2006).

Marco E, Gago F. Mol Pharmacol. 68:1559-1567 (2005).

C2971 Chromostatin, bovine 0.5 mgC78H120N24O35 FW 1953.97 1 mg

2.5 mg

C2968 Chrysin (See page 14 for more information) 5 gC15H10O4 FW 254.2 [480-40-0] 25 gA flavone which inhibits metabolic activation of benzo[a]pyrene.

Chae, Y-H., Ho, D.K., Cassady, J.M., et.al. Chem.-Biol. Int., 82:181-193 (1992).

C2970 Chrysophanol 10 mg1,8-Dihydroxy-3-methyl-9,10-anthracenedione, Chrysophanic acid 25 mgC15H10O4 FW 254.24 [481-74-3] 100 mgAn anthraquinone found in the root of Rheum wittrochii. It has been shown to increase

intracellular Ca2+ concentration and exhibit antifungal activities.

Agarwal SK, Singh SS, Verma S et al. J Ethanopharmacol. 72:43-6 (2000).

Kagedal K, Bironaite D, Ollinger K. Free Radical Res. 31:419-28 (1999).

C2997 Chymostatin 1 mgC20H16N2O4 FW 1809.1 [9076-44-2] 5 mgA highly specific chymotrypsin inhibitor produced by actinomycetes. It also 25 mghas anticarcinogenic properties. It was found to suppress the incidence of 50 mgsquamous cell carcinomas of the anal gland.

Billings PC, Newberne PM, Kennedy AR. Carcinogenesis. 11:1083-6 (1990).

Billings PC, et. Al.,. Proc Natl Aca Sci. 84:4801-5 (1987).

C3208 Ciclopirox Olamine 1 gC12H17NO2.C2H7NO FW 268.36 [41621-49-2] 5 gA substituted pyridone antimycotic with activity against a broad spectrum of dermatophytes,

yeasts, actinomycetes, molds, other fungi, and a variety of bacteria.

Jue SG, Dawson GW, Brogden RN. Drugs. 29:330-341 (1985).

C3210 Ciglitazone (See page 18 for more information) 1 mgC18H23NO3S FW 333.45 [74772-77-3] 5 mgAn antidiabetic thiazolidinedione. A PPAR-gamma agonist. It induces apoptosis, inhibits COX-2.

It provides protection against cancers of the breast, lung, colon and prostrate.

Han S, Roman. J. Biochem Biophys Res Commun. 314:1093-9 (2004).

Ignatenko NA, Babbar N, Mehta D et al. Mol Carcinog. 39:91-102 (2004).

Mitsiades CS, Mitsiades N, Richardson PG et al. Semin Oncol. 30:309-12 (2003).

C3446 Cilnidipine 100 mg C27H28N2O7 FW 492.53 [132203-70-4] 250 mgExcites and inhibits Calcium channels. Used as a potential hypertension drug. 1 gShima, E. American Journal of Hypertension (2008), 21(1), 78-84.

Sakata K. Drugs under experimental and clinical research (2003), 29(3), 117-23

Fujii, S. Journal of Pharmacology and Experimental Therapeutics (1997), 280(3), 1184-1191

O

OOH

HO

HN NH

N

N CHO

O

O

R

H

H

NH

NH

HN COOH

O

OH O

O

OH

CH3

H-Ser-Asp-Glu-Asp-Ser-Asp-

Gly-Asp-Arg-Pro-Gln-Ala-Ser-

Pro-Gly-Leu-Gly-Pro-Gly-Pro-

OH

N

CH3

O

OH

H2NOH

O

OH

H3CO

H3C OH

O

OH3C

OH3C O

OH OH

H3C

O

O

H

OCH3

OHO

OHH3C

OH

CH3

OH

O O

O O CH3

H

OH

O

O

CH3

OH

H

O

NS

O

H

O

N

OOO

H3C

H3C

CH3

O

O

N

O

O


C3246 Cilostazol 50 mgC20H27N5O2 FW 369.46 [73963-72-1] 100 mgA selective inhibitor of phosphodiesterase-III with antiplatelet, antithrombotic 500 mg and vasodilating properties. Cilostazol inhibits colon cancer cell motility and is

effective as an anti-metastasis drug.

Chapman TM, Goa KL. Am J Cardiovasc Drugs. 3:117-38 (2003).

Fareed J, Hoppensteadt DA, Bick RL. Clin Appl Thromb Hemost. 9:101-8 (2003).

Murata K et al. Clin Exp Metastasis.17:525-30 (1999).

Inada H, Shindo H, Tawata M, Onaya T. ife Sci. 65:1413-22 (1999).

C3250 Cimetidine 5 gC10H16N6S FW 252.34 [51481-61-9] 10 gAn immunomodulator. Suppresses the growth of several tumors, including 25 g gastrointestinal cancer. An anti-angiogenic agent. Used in stage IV colorectal cancer.

Scheinfeld N. Dermatol Online J. 9:4 (2003).

Tomita K, Izumi K, Okabe S. J Pharmacol Sci. 93:321-30 (2003).

Yoshimatsu K et al. Gan To Kagaku Ryoho. 30:1794-7 (2003).

C3251 Cinnarizine 10 gC26H28N2 FW 368.51 [298-57-7] 100 gCalcium channel blocker. It is known to induce Parkinsonism.

Teive HA, Troiano AR, Germiniani FM et al. Parkinsonism Relat D. 10:243-5 (2004).

Terland O, Flatmark T. Neuropharmacology. 38:879-82 (1999).

Emanuel MB, Chamberlain JA, Whiting S et al. Brit J Clin Pharmaco. 7:189-95 (1979).

C3260 Ciprofibrate 25 mgC13H14Cl2O3 FW 289.16 [52214-84-3] 100 mgA hypolipidemic compound that can induce proliferation of peroxisomes in liver cells of

rats. Rat tumor liver cell line 7777 underwent apoptosis in vivo.Lalwani ND, Reddy MK, Qureshi SA et al. Hum Toxicol. 2:27-48 (1983).

Clemencet MC, Muzio G, Trombetta A et al. Cancer Lett. 222:217-226 (2005).

C3262 Ciprofloxacin (See page 16 for more information) 5 gC17H18FN3O3 F.W 331.34 [85721-33-1] 25 gIt has activity against anaerobic bacteria in vitro and is used in postexposure 50 gprophylaxis against inhalation anthrax.

Watt B, Brown FV, Jantimicrob. Chemother. 17:605. (1986).

Friedlandeder, A.M., Welkos, S.L. Pitt, M.L., et al J Infect Diseases 167:1239-43 (1993).

C3263 Ciprofloxacin Hydrochloride 5 gC17H18FN3

.HCl.H2O FW 385.82 [86393-35-0] 25 gUsed for the treatment and prevention of bacterial infections. 50 g

C3472 Cisatracurium Besylate 25 mgC53H72N2O12

.2C6H5O3S FW 1243.48 [96946-42-8] 100 mgA neuromuscular blocking drug or skeletal muscle relaxant in the category of non- 500 mgdepolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to facilitate

endotracheal intubation and to provide skeletal muscle relaxation during surgery or

mechanical ventilation.

C3374 Cisplatin (See page 4 for more information) 50 mgcis-Platinum(II)diammine dichloride 100 mg Cl2H6N2Pt FW 300.04 m.p. 270oC (dec.) [15663-27-1] 500 mgA platinum coordination complex with antitumor activity. 1 gTomson, A.J. Rec. Res. Cancer Res. 48: 38 (1974).

Pt

Cl NH3

NH3Cl

N

NN

N

O

HN O

N

HN

SNH

NH

H3C

NCN

H3C

N

N

N

O

COOHF

N

HNHCl

N

O

O

O

O

O

O

O

O

N

O

O

O

O

S SO O O O

OO

O

H3C CH3

Cl

ClO

OH

N

COOHO

F

N

HN


C3477 Citalopram Hydrobromide (See page 18 for more info) 25 mgC20H21FN2O.HBr FW 405.31 [59729-32-7] 100 mgA selective serotonin reuptake inhibitor and antidepressant. It has shown 500 mgevidence of being effective at reducing aberrant motor behaviors in Alzheimer disease.

Pousti A, Deemyad T, Malihi G. Hum Psychopharm. 19:347-50 (2004).

C3576 Citreoviridin A 1 mgC23H30O6 FW 402.48 [25425-12-1] 5 mgA neurotoxic mycotoxin from Penicillium toxicarium, Penicilliuj ochrosalmoneum,

Aspergullus terreus and many other related fungi. It is believed to be the cause of the

acute cardiac Beri-Beri disease. Citreoviridin binds to and inhibit mitochondrial ATPase, thereby uncoupling oxidative phosphorylation.

Vieta I, Savarino A, Papa G, Vidotto V, Cantamessa C, Pugliese A. J Chemother. 1996 Oct;8(5):351-7

Linnett PE, Mitchell AD, Osselton MD, Mulheirn LJ, Beechey RB Biochem J. 1978 Mar 15;170(3):503-10.

C3479 Citrinin 1 mgC13H14O5 FW 250.249 [518-75-2] 5 mgA mycotoxin produced by Penicillum citrinum that has been shown to result in 10 mgenlarged kidneys and livers in young broiler chicks.

Ames DD, Wyatt RD, Marks HL, Washburn KW. Poult Sci. 55:1294-1301 (1976).

C3578 L-Citrulline 1 gC6H12N3O3 FW 175.19 [372-75-8] 5 gAn amino acid first isolated from watermelon. 25 gSchwedhelm, E, British Journal of Clinical Pharmacology (2008), 65(1), 51-59. 100 g

C4274 CKS-17 0.5 mgC87H148N26O24 FW 1942.31 [99273-04-8] 1 mg17-amino acid peptide which is highly immunosuppressive. CKS-17 has also 2.5 mgbeen shown to induce cyclic adenosine monophosphate in vitro.

Haraguchi, S.; Good, R. A.; Cianciolo, G. J.; Engelman, R. W.; Day, N. K. J. Leukoc. Biol. 61:654-66 (1997).

C4402 Cladribine 5 mgC10H12ClN5O3 FW 285.69 [4291-63-8] 10 mgA nucleoside analogue that was found to induce DNA double-strand breaks and cell 25 mgdeath in log-phase Chinese hamster V79 cells.Tanabe K, Hiraoka W, Kuwabara M et al. Chem Biol Interact. 71:167-175 (1989).

C4502 Clarithromycin 100 mgC38H69NO13 FW 747.95 [81103-11-9] 250 mgA macrolide antibiotic. 1 gHardy, D.J., Guay, D.R., Jones, R.N Diagn Microbiol Infect Dis. 15:38-53 (1992).

C4517 Clenbuterol Hydrochloride (See page 24 for more info) 25 mgC12H18Cl2N2O.HCl FW 313.65 [21898-19-1] 100 mgA beta 2 agonist that may potentiate hypoxemia as a result of increased shunt 250 mg fraction in horses anesthetized by the IV route. This beta 2 agonist has also been shown

to enhance memory in sham-lesioned male Sprague Dawley rats.Dodam JR, Moon RE, Olson NC et al. Am J Vet Res. 54:776-782 (1993).

Introini-Collison IB, Miyazaki B, McGaugh JL. Psychopharmacology (Berl). 104:541-544 (1991).

C4510 Climbazole 5 gC15H17ClN2O2 FW 292.76 [38083-17-9] 10 gA potent inducer and inhibitor of P450-dependent drug metabolizing enzymes, 25 gwhich is also used as antifungal and antidandruff agent.Mayser P, Argembeaux H, Rippke F. J Cosmet Sci. 54:263-70 (2003).

Kobayashi Y et al. Biol Pharm Bull. 25:53-7 (2002).

O

O

O

O

O

HO

OH

HO

H

N

HO

O

O

O

O

N

N

CH3O

Cl

O

CH3

CH3

H2N CH

H2CHN C

CH3

CH3

CH3

OHHCl

Cl

Cl

H-Leu-Gln-Asn-Arg-Arg-Gly-Leu-

Asp-Leu-Leu-Phe-Leu-Lys-Glu-

Gly-Gly-Leu-OH

OO

O

O

OHHO

N

N N

N

NH2

O

OH

HO

Cl

O

H3C

CH3

O

CH3

OH

OH

O

H2N NH

O

OH

O

NH2

O

NC

N

CH3

CH3

F

.HBr


C4535 Clinafloxacin Hydrochloride (See page 16 for more info) 100 mgC17H17ClFN3O3

.HCl FW 402.24 [105956-97-6] 250 mgAntimicrobial fluoroquinolone inhibits topoisomerase IV. 1 gPan, X.S., Fisher, L.M. Antimicrob Agents Chemother. 43:1129-36 (1999).

C4532 Clindamycin Hydrochloride 10 mgC18H34Cl2N2O5S FW 461.44 m.p. 141-1430C [21462-39-5] 50 mgAn effective antibacterial agent against gram-positive bacteria. Clindamycin HCl 100 mgattaches to the 50S subunit of bacterial ribosomes and suppresses protein synthesis.

Reusser, F. Antimicrobial Agents Chemother. 7: 32 (1975).

C4534 Clindamycin Palmitate HCl 10 mgC34H63ClN2O6S FW 663.39 [25507-04-4] 50 mgInactive molecule which is hydrolyzed into its active form by 100 mgsmall-intestine enzymes.

Cimbollek, M., Nies, B., Liebendorfer, A., Wenz, R. J. Controlled Release 33:47-53 (1995).

C4533 Clindamycin Phosphate 10 mgC18H34ClN2O8PS FW 504.96 [24729-96-2] 50 mgThe 2-dihydrogen phosphate analog of Clindamycin. 100 mg

C4659 Clobetasol Propionate 100 mgC25H32ClFO5 FW 466.98 [25122-46-7] 500 mgAn anti-inflammatory, antipruritic and vasoconstrictive agent. Shown to be 1 geffective against tufted angioma.

Melian EB, Spencer CM, Jarvis B. Am J Clin Dermatol. 2:89-92; discussion 93 (2001).

Bernstein EF, Kantor G, Howe N et al. J Am Acad Dermatol. 31:307-11 (1994).

C3449 Clodronate Disodium 10 mgCH2Cl2Na2O6P2

.4H2O FW 360.925 [22560-50-5] 50 mgA bisphosphonate bone resorption inhibitor. 100 mgPlosker, G.L., Goa, K.L. Drugs 47:945-82 (1994).

C4646 Clofarabine 10 mgC10H11CLFN5O3 FW 303.68 [123318-82-1] 25 mgA purine nucleoside anti-metabolite which is used in the treatment of acute 100 mglymphoblastic leukemia.

Steinherz, P. G. Journal of Pediatric Hematology/Oncology (2007), 29(9), 656-658

Krynetskaia, N. Molecular Pharmacology (2008), 73(1), 260-269.

Faderl, S. Blood (2008), 112(5), 1638-1645.

C4557 Clofibrate 1 g2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester 5 gC12H15ClO3 FW 242.70 [637-07-0]A peroxisome proliferator and hypolipidemic drug. Induces apoptosis in hepatoma cells.

Also a liver tumor promoter.

Canuto, R.A.,, Muzio, G., Bonelli, G., et al. Cancer Detect Prev. 22:357-66 (1998).

Adinehzadeh, M., Reo, N.V. Chem Res Toxicol 11:428-40 (1998).

C4556 Clofibric acid 10 gC10H11ClO3 FW 214.65 [882-09-7] 50 gA drug used to reduce cholesterol levels in the blood.

N

O

H

H

H H

H

CH2CH2CH3

H

CONH

CH3

C

HCCl

H

CH3

OH

H

OH

H

H

OH

H

SCH3

. HCl

N

O

H

H

H H

H

CH2CH2CH3

H

CONH

CH3

C

HCCl

H

CH3

OH

H

OH

H

H

OPO3H2

H

SCH3

N

CH3

C3H7

C NH

O

CH

CH Cl

CH3

O

OH

OH

O

SCH3

C(CH2)14CH3

O

HCl

Cl OCCOOC2H5

CH3

CH3

Cl OCCOOH

CH3

CH3

N N

O

CO2HF

.HCl

Cl

H2N

O

P P

O

Cl

Cl

ONa

OH

ONa

OH

4H2O

O

Cl

CH3

O

CH3 H

CH3

HO

OH

F H

N

NN

N

NH2

Cl

OF

OH

HO


C4559 Clomiphene Citrate 1 gClomifene citrate 5 gC26H28ClNO.ClNO.C6H8O7 FW 598.09 [50-41-9] 10 gA selective estrogen receptor modulator. It is used as an antileukemic drug which kills cells

by apoptosis mediated by oxidative stress and activation of PKC.

Haskell SG. South Med J. 96:469-76 (2003).

Hayon T, Dvilansky A, Oriev L, Nathan I. Anticancer Res. 19:2089-93 (1999).

C4558 Clonidine HCl 250 mgC9H10ClN3 FW 266.55 [4205-91-8] 1 gis a direct-acting α2 adrenergic agonist prescribed historically as an antihypertensive agent.

Pettibone, Douglas J., Brain Research (1981), 221(2), 409-14.

C4658 Clopidogrel Sulfate 500 mgC16H16ClNO2S.H2SO4 FW 419.90 [135046-48-9] 1 gAn ADP receptor antagonist that inhibits platelet aggregation. 5 gLecompte T. Arch Mal Coeur Vaiss. 94:1225-32 (2001).

Reist M et al. Drug Metab Dispos. 28:1405-10 (2000).

C4656 Clopidol 1 gC7H7Cl2NO FW 192.04 [2971-90-6] 5 gAn antiplatelet drug. 25 gIzaguirre-Avila R et al. Clin Appl Thromb Hemost. 8:169-77 (2002).

C4758 Closantel 1 gC22H14Cl2I2N2O2 FW 663.07 [57808-65-8] 5 gA potent anthelmintic agent that is also used in combination with levamisole to 25 g control gastrointestinal infection in sheep.

Swan GE. J S Afr Vet Assoc. 70:61-70 (1999).

Maingi N, Munyua WK, Gichigi MN. Acta Trop. 84:93-100 (2002).

C4657 Clotrimazole 5 gC22H17ClN2 FW 344.84 [23593-75-1] 10 gAn antifungal imidazole, found to inhibit Ca (2+)-dependent K+ transport and cell 25 g dehydration in sickel erythrocytes.

Brugnara, C., de Franceschi, L. Alper, S.L. J Clin Invest. 92:520-6 (1993).

C4756 Cloxacillin sodium 1 gC19H18ClN3NaO5S.H2O FW 475.88 [7081-44-9] 5 gA semi-synthetic antibiotic related to penicillin. 25 gMattie H, Zhang LC, van Strijen E et al. Antimicrob Agents Ch. 41:2083-8 (1997).

Dan M, Asherov J, Poch F. Diagn Micr Infec Dis. 33:39-42 (1999).

C4757 Clozapine 25 mgClozaril, Leponex 100 mgC18H19ClN4 FW 326.82 [5786-21-0]Antipsychotic drug. It is effective in the treatment of levodopa-induced dyskinesias in severe

Parkinson's disease, and it increases both acetylcholine and dopamine release in rat ventral hippocampus.

Chung YC, Li Z, Dai J et al. Brain Res. 1023:54-63 (2004).

Durif F, Debilly B, Galitzky M et al. Neurology. 62:381-8 (2004).

N

N

C

Cl

N CH3

Cl

OH

Cl

H3C

Cl

O

NH3C

H3C

N

S Cl

O OCH3

I

I

OH

NH

O

CN

CH3

Cl

Cl

N

NH

N

N

Cl

N

SNH

HH

O

CH3

CH3

COONa. H2O

O

N

O

Cl

CH3

Cl

Cl

HN

N

HN

HCl


C4759 Clozapine N-oxide 5 mgC18H19ClN4O FW 342.82 [34233-69-7] 25 mgIs an antipsychotic medication used in the treatment of schizophrenia. It binds to

serotonergic and dopaminergic receptors and has a high affinity for the D4 receptor.

It has also been suggested that is is a partial agonist at the 5-HTIA receptor.

Also an agonist at the adrenergic, cholinergic and histaminergic receptors.Martinez, V. Neuropsychopharmacology (2008), 33(11), 2635-2647.

Selent, J. ChemMedChem (2008), 3(8), 1194-1198.

C5196 C-Myc Peptide 1 mgC51H86N12O1 FW 1203.32 2 mg

5 mg

C5260 CNP-22, human, porcine, rat 1 mgC93H157N27O28S3 FW 2797.61CNP-22 stimulates the drinking of water. It has also been shown to inhibit proliferation

and and monocyte protein-1 secretion in human measangial cells. Osawa, H.; et. al. Neph. Jour. 86: 467-472 (2000).

C5645 Colchicine, 97 % 500 mgC22H25NO6 FW 399.44 [64-86-8] 1 gMicrotubule disrupting agent that induces apoptosis in human lymphoma cells

and neuroblastoma cells.

Takano, Y., Okudaira, M., Harmon, B.V. Pathol Res Pract. 189:197-203 (1993).

Nakagawa-Yagi, Y. Biochem Biophys Res Commun. 199:807-17 (1994).

C5647 Colistin sulphate 100 mgFW 1267.55 [1264-72-8] 500 mgA cationic polypeptide antibiotic from the polymyxin family. It is effective in 1 gthe management of Pseudomonas aeruginosa infections in patients with 5 gcystic fibrosis.

Beringer P. Curr Opin Pulm Med. 7:434-40 (2001).

Evans ME, Feola DJ, Rapp RP. Ann Pharmacother. 33:960-7 (1999).

C5646 Collagen Binding Fragment 1 mgC52H75N14O20S FW 1248.32 2 mg

5 mg

C5654 Concanavalin A 50 mg[11028-71-0] 250 mgA plant lectin that is a T cell mitogen. It induces apoptosis in human fibroblasts. 500 mgNagase, F., Abo, T., Hiramatsu, K., et al. Microbiol Immunol. 42:567-74 (1998). 1 gKulkarni, G.V., Lee, W., Seth, A., McCulloch, C.A., Exp Cell Res. 245:170-8 (1998).

C5655 α-Conotoxin GI 0.5 mgC55H76N20O18S4 FW 1433.63 [156467-85-5] 1 mgCauses postsynaptic inhibition at the neuromuscular junction. 2.5 mgGray, W. R.; Luque, A.; Olivera, B. M.; Barrett, J.; Cruz, L. J. J. Biol. Chem. 256:4734, (1981).

C5656 α-Conotoxin IMI 0.5 mgC52H74N20O15S4 FW 1347.58 1 mg

2.5 mg

CH3O

CH3O

CH3O

O

OCH3

NHCOCH3

R L-DAB Thr

!"NH2

L-DAB

!"NH2

L-DAB

L-DAB

!"NH2

Thr L-DAB

!"NH2

L-DAB

!"NH2

D-Leu Leu

DAB=#,!-diaminobutyric acid

R = (+)-6-methyloctanoyl

H-Glu-Gln-Lys-Leu-Ile-Ser-Glu-

Glu-Asp-Leu-OH

Gly-Leu-Ser-Lys-Gly-Cys-Phe-

Gly-Leu-lys-Leu-Asp-Arg-Ile-

Gly-Ser-Met-Ser-Gly-Leu-Gly-

Cys


H-Cys-Gln-Asp-Ser-Glu-Thr-Arg-

Thr-Phe-Tyr-OH

H-Glu-Cys-Cys-Asn-Pro-Ala-Cys-

Gly-Arg-His-Tyr-Ser-Cys-NH2

(Cys2-Cys7, Cys3-Cys13)

H-Gly-Cys-Cys-Ser-Asp-Pro-Arg-

Cys-Ala-Trp-Arg-Cys-NH2


NH

N

Cl

N

NCH3

O


C5662 Copper bis-3,5-diisopropylsalicylate 1 gC26H34O6Cu FW 506.11 [21246-18-4] 5 gA superoxide dimutase compound that inhibits protein kinase C in rat liver and reduces the

activity of TPA stimulated protein kinase C. It is shown that a pretreatment of normal

golblet cells of the colonic mucosa by this material sensitizes them to apoptosis induced

by sodium deoxycholate (bile salt).

Nilsson K, Cancer Lett. 47: 169-77 (1989).

Washo-Stultz D, Holgen N, Bernstein H, Bernstein C, Payne CM. Nutr Cancer. 35:180-8 (1999).

C5768 Corazonin 1 mgC62H86N18O19 FW 1369.46 [122984-73-0] 2 mgA potent cardioactive peptide isolated from a variety of insects. 5 mgPredel R, Neupert S, Russell WK, Scheibner O, Nachman RJ. Peptides. 28: 3-10 (2006).

C5968 Cordycepin 10 mgC10H13N5O3 FW 251.24 [73-03-0] 25 mgA nucleoside that was first isolated from the cultures of cordyceps militaris. It also 100 mginhibit SW480 and SW620 cell proliferation and induce apoptosis by enhancing JNK

and P38 kinase activity and increasing the protein expression of Bvl-2 pro-apoptotic molecules.

Jagger, D.V., Kredich, N.M, Guarino, A.J Cancer Res. 21:216-220 (1961).

Pan, B-S, Lin, C-Y, Huang, B-M Evid. Based Complement Alternat. Med. 2011 2011:75064.

C5771 Corticosterone 100 mgC21H30O4 FW 346.46 [50-22-6] 250 mgElevation of plasma corticosterone level induces apoptosis 500 mgin murine bone marrow.

Garvy, B.A., King, L.E., Telford, W.G., et al. Immunology. 80:587-92 (1993).

C5770 Corticotropin Releasing Factor, bovine 0.5 mgC206H340N60O63S FW 4697.44 1 mgIt is a neurotransmitter which also releases ACTH and endorphin from the anterior 2.5 mgpituitary.

Eckart, K., et al. Curr. Med. Chem. 6:1035-1053 (1999).

C5772 Corticotropin Releasing Factor, human, rat 0.5 mgCRF 1 mgC208H344N60O63S2 FW 4757.49 [86784-80-7] 2.5 mg

C5774 Corticotropin Releasing Factor, ovine 0.5 mgC205H339N59O63S FW 4370.41 1 mg

2.5 mg

C5773 Cortistatin 14, (rat) 0.5 mgC81H113N19O19S2 FW 1721.02 [186901-48-4] 1 mgA neuropeptide that binds all SS receptor subtypes and ghrelin's receptors. 2.5 mg It has been found to inhibit cell proliferation of human thyroid carcinoma cell lines.Broglio F, Arvat E, Benso A et al. J Clin Endocrinol Metab. 87:3783-90 (2002).

Cassoni P, Muccioli G, Marrocco T et al. J Endocrinol Invest. 25:362-8 (2002).

O

CH3

HOCH3

O

CH2OH

OHCH

CH

O

O

CH3

H3C

H3C

H3C

Cu

HO CH

CH

O

O

CH3

CH3

CH3

CH3

H-Ser-Gln-Glu-Pro-Pro-Ile-Ser-

Leu-Asp-Leu-Thr-Phe-His-Leu-

Leu-Arg-Glu-Val-Leu-Glu-Met-

Thr-Lys-Ala-Asp-Gln-Leu-Ala-

Gln-Gln-Ala-His-Asn-Asn-Arg-

Lys-Leu-Leu-Asp-Ile-Ala-NH2

pGlu-Thr-Phe-Gln-Tyr-Ser-Arg-

Gly-Trp-Thr-Asn-NH2

H-Ser-Gln-Glu-Pro-Pro-Ile-Ser-



Thr-Lys-Ala-Asp-Gln-Leu-Ala-

Gln-Gln-Ala-His-Ser-Asn-Arg-

Lys-Leu-Leu-Asp-Ile-Ala-NH2

H-Pro-Cys-Lys-Asn-Phe-Phe-

Trp-Lys-Thr-Phe-Ser-Ser-Cys-

Lys-OH


Ser-Glu-Glu-Pro-Pro-Ile-Ser-



Ala-Arg-Ala-Glu-Gln-Leu-Ala-

Gln-Gln-Ala-His-Ser-Asn-Arg-

Lys-Leu-Met-Glu-Ile-Ile-NH2


C5782 Coumarin 10 g2H-1-Benzopyan-2-one 50 gC9H6O2 FW 146.14 [91-64-5]An anticoagulant found in medicinal plants and used in phytomedicine for the treatment of venous

diseases. It is found to have anti-tumor activities in several human cells lines.

Weber US, Steffen B, Siegers CP. Res Commun Mol Pathol Pharmacol. 99:193-206 (1998).

Pineo G, Hull RD. Hematol Oncol Clin North Am. 17:201-16 (2003).

C5680 Coumestrol 10 mgC15H8O5 FW 268.2 [479-13-0] 25 mgA plant estrogen and highly potent inhibitor of 17-b-hydroxysteroid oxidoreductase.

Poutanen, M., Lehtimaki, J., Kostian, M.L., Santti, R., Vihko, R. Proc.Soc.Exp.Biol.Med. 208:51-59 (1995).

C6018 C-Peptide, dogs 0.5 mgC137H225N37O49 FW 3174.54 1 mg

2.5 mg

C6019 C-Peptide, human 0.5 mgC129H211N35O48 FW 3020.33 1 mg

2.5 mg

C6916 CREBtide 1 mgC73H127N29O18 FW 1699.01 2 mgA peptide substrate commonly associated with protein kinase A. 5 mgWu J, Vajjhala S, O’Connor S. Assay Drug Dev Technol. 5:559-566 (2007).

C6955 Cromolyn sodium 1 gC23H14Na2O11 FW 512.3 [15826-37-6] 5 gA chemopreventive and anti-inflammatory agent. In rats, it was found that

application of cromolyn sodium prior to benzo[a]pyrene administration prevents tumor

formation and provokes a significant inhibition of the carcinogenic process.

Matsuo N, Shinoda T, Matsuse H, Obase Y, Asai S, Kohno S. Ann allergy Asthma Immunol. 84:72-8 (2000).

Vickova A, Horakova K, Sloboda J, Ulrich L, Babinska M, Babulova A. Carcinogenesis. 7:371-4 (1986).

C6956 Crotamiton 25 gC13H17NO FW 203.28 [483-63-6] 100 gUsed in the treatment of scabies, crotamiton with phototherapy. Effective against pruritus of breast

carcinoma skin infiltration.

Buffet M, Dupin N. Fundam Clin Pharmacol. 17:217-25 (2003).

Holme SA, Mills CM. J Pain Symptom Manage. 22:803-5 (2001).

C6957 Croton Oil 100 g[8001-28-3] 1 kgA natural source of phorbol and phorbol esters.

Crotalus durissus terrificus (See snake venom)

C6982 Crustacean Cardioactive Peptide, CCAP 1 mgC42H56N10O12S2 FW 957.1 2 mg

5 mg

C7097 Cryptotanshinone 10 mgC19H20O3 FW 296.36 [35825-57-1] 25 mgA quinoid diterpene isolated from the root of the Chinese medicinal plant Salvia 100 mg miotiorrhiza bunge. It has antibacterial and antimutagenic activities. Its antibacterial

activity was attributed to its ability to generate superoxide radicals.

Pan, X., Niu, G., Liu, H. J. Chromatography A. 922:371-375 (2001).

Lee, D.S., Lee, S.H., Noh, J.G., Hong, S.D. Biosci Biotech Biochem. 63:2236-2239 (1999).

O

O

O

HO

OH

O O

O COONa

OOCH2CHCH2O

OH

ONaOOC

O

N

CH3

CH3H3C

O

H-Glu-Val-Glu-Asp-Leu-Gln-

Val-Arg-Asp-Val-Glu-Leu-Ala-

Gly-Ala-Pro-Gly-Glu-Gly-Gly-

Leu-Gln-Pro-Leu-Ala-Leu-

Glu-Gly-Ala-Leu-Gln-OH

H-Glu-Ala-Glu-Asp-Leu-Gln-

Val-Gly-Gln-Val-Glu-Leu-Gly-

Gly-Gly-Pro-Gly-Ala-Gly-Ser-

Leu-Gln-Pro-Leu-Ala-Leu-Glu-

Gly-Ser-Leu-Gln-OH

H-Lys-Arg-Arg-Glu-Ile-Leu-Ser-

Arg-Arg-Pro-Ser-Tyr-Arg

H-Pro-Phe-Cys-Asn-Ala-Phe-

Thr-Gly-Cys-OH


O

H3C CH3

O

O

CH3


C7098 Crystalline 1 mgC12H15N3O3 FW 261.2 2 mg

5 mg

C7602 CTAP 0.5 mgC51H67N13O11S FW 1102.33 1 mgµ-selective opioid receptor antagonist. 2.5 mgAbbruscato, T. J.; Thomas, S. A.; Hruby, V. J.; Davis, T. P. J. Pharmacol. Exp. Ther. 280:402 (1997).

C7618 C-telopeptide 0.5 mgC34H56N14O13 FW 868.91 1 mg

2.5 mg

C7692 CTX IV (6-12) 1 mgC48H70N10O7 FW 899.14 2 mgToxin with cytolytic activity expressed by the venom gland of the Egyptian cobra. 5 mg

C7693 [Arg3,14] CTX IV (3-14) 1 mgC74C119N25O14 FW 1582.91 2 mgToxin with cytolytic activity expressed by the venom gland of the Egyptian cobra. 5 mg

C7997 C-Type Natriuretic Peptide (1-22), human 0.5 mgC93H157N27O28S3 FW 2197.64 1 mgC-type natriuretic peptide (CNP) is a peptide produced by the vascular 2.5 mgendothelium with vasodilative properties. CNP was found to play an important role

in linear growth and is believed to be an endothelium-derived hyperpolarizing factor.

Sandow, S. L.; Tare, M. Trends Pharmacol. Sci. 28:61-7 (2007).

Olney, R. C. Growth Horm. IGF Res. A:S6-14 (2006).

C7998 C-Type Natriuretic Peptide, chicken 0.5 mgC93H157N29O29S3 FW 2241.66 1 mg

2.5 mg

C8017 Cuelure 100 mg4-(3-Oxobutyl)phenyl acetate 250 mgC12H14O3 FW 206.24 [3572-06-3] 1 gAn insect sex hormone used to interrupt the mating of melon flies.

C8069 Curcumin (See page 10 for more information) 5 gC21H20O6 FW 368.38 m.p. 1830C [458-37-7] 10 gAn antipromoter with antioxidant and anti-inflammatory 50 gactivities. Inhibits lipoxygenase and cyclooxygenase.Huang, M-T., Lysz, T., Ferraro, T et al. Cancer Res., 51:813-819 (1991).

C8500 CV-65 100 µgC13H7N2O4 FW 270.24 1 mgDiaza-anthracene compound known to inhibit ERK and JNK kinases.

Pipaon, C., Gutierrez, P., Montero, J.C., et al Mol.Cancer Ther. 10:811-819 (2002).



CH3O

HO

CH2

O

OCH3

OH

O

NH

NH

O

O

OO

NH

N

O

O

O

-O

+

H-Trp-Gly-OH

H-D-Phe-Cys-Tyr-D-Trp-Arg-

Thr-Pen-Thr-NH2

(Disulfide bridge Cys2-Pen7)

H-Glu-Lys-Ala-His-Asp-Gly-

Gly-Arg-OH

Leu-Ile-Pro-Pro-Phe-Trp-Lys-

NH2

Arg-Asn-Arg-Leu-Ile-Pro-Pro-

Phe-Trp-Lys-Thr-Arg-NH2

H-Gly-Leu-Ser-Lys-Gly-Cys-

Phe-Gly-Leu-Lys-Leu-Asp-

Arg-Ile-Gly-Ser-Met-Ser-Gly-

Leu-Gly-Cys-OH


H-Gly-Leu-Ser-Arg-Ser-Cys-

Phe-Gly-Val-Lys-Leu-Asp-Arg-

Ile-Gly-Ser-Met-Ser-Gly-Leu-

Gly-Cys-OH


O

CH3

O

H3C

O




C9600 Cyanopeptolin 1007 (See page 31 for more information) 50 µgC49H70N10O13 FW 1007.20 [791104-89-7]It is a cyclic non-ribosomal peptide isolated from various cyanobacteria, reported to

inhibit serine proteases such as trypsin and chymotrypsin. Sold under license by

LKT from the manufacturer, MARBIONC.Martin, C. et al. J. Antibiot. (1993) 46, 1550–1556.

Von Elert, E. et al. J. Nat. Prod. (2005) 68, 1324–1327.

C9602 Cyanopeptolin 1041 (See page 31 for more information) 50 µgC49H69ClN10O13 FW 1041.70It is a cyclic non-ribosomal peptide isolated from various cyanobacteria, reported to

inhibit serine proteases such as trypsin and chymotrypsin. Sold under license by

LKT from the manufacturer, MARBIONC.Martin, C. et al. J. Antibiot. (1993) 46, 1550–1556.

Von Elert, E. et al. J. Nat. Prod. (2005) 68, 1324–1327.

C9677 Cyclocytidine hydrochloride 1 g2,2'-Anhydro-1-b-D-arabinofuranosylcytosine hydrochloride 5 gC9H11N3O4

.HCl FW 261.6 m.p. 269-2700C (dec.) [10212-25-6]

An antitumor agent.

Hoshi, A., Kanzawa, F., Kuretani, K. Gann., 63:353-360 (1972).

Ip, C., Ganther, H.E. Carcinogenesis 7:1167-1170 (1992).

C9709 Cycloheximide 1 gC15H23NO4 FW 281.35 [68-81-9] 5 gA protein synthesis inhibitor. Induces apoptosis in tumor cell lines.

Collins, R.J., Harmon, B.V., Souvlis, T., et al. Br J Cancer. 64:518-22 (1991).

Gong, J., Li, X., Darzynkiewicz, Z. J Cell Physiol. 157:263-70 (1993).

Ishii, H.H., Etheridge, M.R., Gobe, G.C. Immunol Cell Biol. 73:463-8 (1995).

C9710 Cyclopamine (See Page 23 for more information) 5 mgC27H41NO2 FW 411.62 [4449-51-8] 25 mgA steroidal alkaloid isolated from the desert plant Veratrum californicum with both 100 mgteratogenic and antitumor activities. It inhibits hedgehog/smoothened signaling. 500 mgCoventry S, Kapur RP, Siebert JR. Pediatr Devel Pathol. 1:29-41 (1998). 1 gChen JK, Taipale J, Cooper MK et al. Gene Dev. 16:2743-8 (2002).

Qualtrough D, Buda A, Gaffield W et al. Int J Cancer. 110:831-7 (2004).

C9609 Cyclophosphamide (See page 4 for more information) 1 gC7H15Cl2N2O2P.H2O FW 279.10 m.p. 49-510C [6055-19-2] 5 gAn alkylating agent used in cancer therapy. Induces apoptosis in tumor cells and endothelial cells

within tumors.

Meyn, R.E., Stephens, L.C., Hunter, N.R., Milas, L. Cancer Chemother Pharmacol 33:410-4 (1994).

Browder, T., Butterfied\ld, C.E., ktaling, B.M. et al Cancer Res. 60:1878-86 (2000).

C9809 Cyclopiazonic acid 5 mgC20H20N2O3 FW 336.39 [181172-33-3] 10 mgAn inhibitor of the sarco/endoplasmic reticulum calcium pump that has produced hypokinesia,

hypothermia, catalepsy, ptosis, and sedation without loss of righting reflex, tremor, gait disturbance,

dyspnoea, opisthotonus, atypical convulsion, and prolonged barbiturate-induced sleep in mice.

Nishie K, Cole RJ, Dorner JW. Food Chem Toxicol. 23:831-839 (1985).

Gover TD, Moreira TH, Kao JP, Weinreich D. Cell Calcium. 41:389-396 (2007).

NH

P

O

O

N

Cl

Cl

HN

CH3

O

H3C

O

O OH

O

HN

HO

CH3

CH3

HH

H

H

HH3C

H3C

NH

NH

O

O

O O

N

N

N

HO

O

HO

HO

HCl

NH

O

HO

O

O

HN

O

O NH

O

HN

O

O

NH

N

NH

NH2

HN

O OH

N

O

OH

N

HN

OO

O

HN

OHN

N

NH

HN

O

O

O

NH

Cl

OH

OH

NH2HN

O

OH

OO

N

NHH3C

OOH

O

H

H3CCH3

H

H


C9610 D-Cycloserine 1 gC3H6N2O2 FW 102.09 [68-41-7] 5 gA partial NMDA receptor allosteric agonist found to improve cognitive functions in humans.

Nitsche MA, Jaussi W, Liebetanz D et al. Neuropsychopharmacology. 29:1573-8 (2004).

Ogawa M, Shigeto H, Yamamoto T et al. J Neurol Sci. 210:53-6 (2003).

C9611 Cyclosporin A (See page 19 for more information) 10 mg C62H111N11O12 FW 1202.0 [59865-13-3] 50 mgImmunosuppressive, nonpolar, cyclic oligopeptide. Inhibits the activity of 100 mg transcription factors of NFAT cell family. Interferes with the induction of cytokines and other inducibles

immune response genes. Induces apoptosis and inhibits angiogenesis induced by VEGF.

Wiederrecht, G., Lam, E., Hung, S., et al. Ann N Y Acad Sci. 696:9-19 (1993).

Mongini, C., Waldner, C., Lopes, E.C. et al. Int. J Mol Med. 7:431-7 (2001).

Hernandez, G.L., Volpert, O.V., Iniguez, M.A. et al. J Exp Med. 193:607-20 (2001).

C9615 Cyclosporin B (See page 19 for more information) 1 mgC61H109N11O12 FW 1188.59 [63775-95-1] 5 mg

C9612 Cyclosporin C (See page 19 for more information) 1 mgC62H111N11O13 FW 1218.61 [59787-61-0] 5 mg

C9613 Cyclosporin D (See page 19 for more information) 1 mgC63H113N11O12 FW 1216.64 [63775-96-2] 5 mg

C9614 Cyclosporin H (See page 19 for more information) 1 mgC62H111N11O12 FW 1202.61 [83602-39-5] 5 mg

C9711 Cyclovirobuxine D 25 mgC26H46N2O FW 402.66 [860-79-7] 100 mgAn anti-atrial fibrillating agent. It induces release of endothelial nitric oxide. 500 mgWang YX, Zheng YM, Tan YH, Sheng BH. Yao Xue Xue Bao. 31:481-6 (1996).

Grossini E et al. Life Sci. 65:PL59-65 (1999).

C9660 Cypermethrin 10 mgC22H19Cl2NO3 FW 416.30 [52315-07-8] 25 mgSynthetic pyrethroid insecticide that inhibits protein phosphatase. It was found 100 mg to induce cytochrome P450 2B1 in primary rat hepatocyte cultures.

Enan, E., Matsumura, F. Biochem Pharmacol 43:1777-84 (1992).

Heder, A.F., Hirsch-Ernst, K.I., Bauer, D. et al Biochem Pharmacol 62:71-9 (2001).

C9863 Cyproconazole (See page 16 for more information) 5 gC15H18ClN3O FW 291.78 [94361-06-5] 10 gCyproconazole is a triazole fingicide which causes hepatocellular adenomas 100 gand carcinomas.

Matsumura, M. Jpn. Kokai Tokkyo Koho (2007).

Mol, H. G. J. Analytical and Bioanalytical Chemistry (2007), 389(6), 1715-1754.

H3C

N

N

N

HN

N

CH3

H3C

N

NH

HN

N

HN

CH2CH(CH3)2

CH3 O O

H3C

HOCH3

OCH3

CH(CH3)2

O

O

CH3 O

CH3O

CH2CH(CH3)2

CH3

O

CH(CH3)2

O

N CH3

O

O

OH

H3C

N

N

N

HN

N

CH3

H3C

N

NH

HN

N

HN

CH2CH(CH3)2

CH3 O O

H3C

HOCH3

OCH3

CH(CH3)2

O

O

CH3 O

CH3O

CH2CH(CH3)2

CH3

O

CH(CH3)2

O

N CH3

O

O

H3C

N

N

N

HN

N

CH3

H3C

N

NH

HN

N

HN

CH2CH(CH3)2

CH3 O O

H3C

HOCH3

OCH3

CH(CH3)2

O

O

CH3 O

CH3O

CH2CH(CH3)2

CH3

O

CH(CH3)2

O

N CH3

O

O

OO

O CN

CH3H3C

Cl

Cl

NH

H

CH3

H

CH3

OH

HN

CH3

H3C

H3C CH3

H3C

H3C

N

N

N

HN

N

CH3

H3C

N

NH

HN

N

HN

CH2CH(CH3)2

CH3 O O

H3C

HOCH3

O CH3CH3

CH(CH3)2

O

O

CH3 O

CH3O

CH2CH(CH3)2

CH3

O

CH(CH3)2

O

N CH3

O

O

NH

O

OH2N

H3C

N

N

N

HN

N

CH3

H3CN

NH

HN

N

HN

CH2CH(CH3)2

(CH3)2CHCH2 CH3 O O

H3C

HOCH3

O RCH3CH(CH3)2

O

(CH3)2CHCH2

O

CH3 O

CH3O

CH2CH(CH3)2

CH3

O

CH(CH3)2O

N CH3

O

O

OH

N

Cl

H3C

N

N


C9662 Cyproterone Acetate 100 mgC24H29ClO4 FW 416.94 [427-51-0] 250 mgA hepatomitogen and tumor promoter. Induces apoptosis in hepatocytes. 1 gOberhammer, F.A., Pavelka, M., Sharma, S., et al. Proc. Natl Acad Sci, USA. 89:5408-12 (1992).

Kasper, P., Mueller, L. Carcinogenesis. 20:2185-8 (1999).

C9670 Cyromazine 25 gC6H10N6 FW 166.18 [66215-27-8] 100 g A non-organophosphorus insect growth regulator.

Jukes AA, Collier RH, Finch S. Meded. Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet. 66:395-402 (2001).

Schwartz L, Wolf D, Markus A et al. J Agric Food Chem. 51:5972-6 (2003).

C9673 Cysteamine Hydrochloride 25 g2-Aminoethanothiol hydrochloride 100 gC2H7NS.HCl FW 113.61 m.p. 66-680C [156-57-0]An inhibitor of DMBA-induced mammary tumors.

Tatsuta M, Iishi H, Baba M, Taniguchi H. International Journal of Cancer. 48:605-8 (1991).

IP C, Ganther HE. Carcinogenesis. 13:1167-70 (1992).

Tatsuta M, Lishi H, Baba M, Taniguchi H. International Journal of Cancer. 44:1008-11 (1989).

C9773 L-Cystine 25 gC6H12N2O4S2 FW 240.30 [56-89-3] 100 gNon-essential amino acid vital for human development formed by the 500 gdimerization of two cysteines. Its derivatives as ligangs for neuronal nicotine receptors

and have various pharmacological activities.

Boido CC, Tasso B, Boido V, Sparatore F. Farmaco. 58:265-77 (2003).

Breining SR. Curr Top Med Chem. 4:609-29 (2004).

C9778 Cytarabine 100 mgCytosine b-D-arabinofuranoside 500 mgC9H13N3O5 FW 243.22 [147-94-4] 1 gCytarabine (Cytosine beta-D-arabinofuranoside) is an antimetabolite compound which is proven

to be one of the most effective agents available to treat leukemia. It exerts its cytotoxic effect

by inactivating DNA polymerases alpha, delta, and epsilon.

Tothova E, Fricova M, Kafkova A et al. Neoplasma. 47:125-8 (2000).

Mirzayans R, Cubitt S et al. Carcinogenesis. 15: 2319-24 (1994).

Okamura T, Hinyokika Kiyo. 34:1895-902 (1992).

C9779 Cytisine 5 mgC11H14N2O FW 190.24 [485-35-8] 25 mgPotent ligand for many nAChR subtypes. Known for analgesic, antihypertensive 100 mgand inotropic activities.Boido CC, Tasso B, Boido V, Sparatore F. Farmaco. 58:265-77 (2003).

C9878 Cytochalasin A 1 mgC29H35NO5 FW 477.60 [14110-64-6] 5 mgAn anti-cytoskeletal drug which inhibits actin polymerization and has caused low stationary

motility and membrane ruffling in K1735-M2 mouse melanoma cells.

Suelmann R, Fischer R. Cell Motil Cytoskeleton. 45:42-50 (2000).

Torralba S, Raudaskoski M, Pedregosa AM, Laborda F. Microbiology. 144(Pt 1):45-53 (1998).

Hofmann-Wellenhof R, Smolle J, Helige C et al. Exp Dermatol. 3:219-226 (1994).

C9879 Cytochalasin B 1 mgC29H37NO5 FW 479.61 [14930-96-2] 5 mgAn actin-disrupting agent that blocks activated hKv1.5 channels and endogenous

I(K,ur) in a cytoskeleton-independent manner.

Choi BH, Park JA, Kim KR et al. Am J Physiol Cell Physiol. 289:C425-436 (2005).

CH2OH

H

H

OH

OH

H

H

N

O

N

O

NH2

H2C

OCOCH3

CH3

O

Cl

CH3

O

CH3

N

NH

O

HO S

S OH

O

ONH2

NH2

N N

NHNH2N

NH2

HSNH2

HCl

HN

H3C

CH2

OH

O

HH

CH3

OH

OO

HN

H3C

CH2

OH

O

HH

CH3

O

OO


C9880 Cytochalasin C 1 mgC30H37NO6 FW 507.62 [22144-76-9] 5 mgAn actin-disrupting agent that increases the rate of transcription of the TGF-beta 1 gene

and of the collagenase gene.

Varedi M, Ghahary A, Scott PG, Tredget EE. J Cell Physiol. 172:192-199 (1997).

C9881 Cytochalasin D 1 mgC30H37NO6 FW 507.62 [22144-77-0] 5 mgAn anti-cytoskeletal drug that promotes actin depolymerization.

D'Souza VM, Bareford LM, Ray A, Swaan PW. J Nutr Biochem. 17:821-829 (2006).

C9882 Cytochalasin E 1 mgC28H33NO7 FW 495.57 [36011-19-5] 5 mgAn inhibitor of actin microfilament polymerisation that strongly induces interleukin-8through epithelial cell line HeLa.Yun BW, Atkinson HA, Gaborit C et al. Plant J. 34:768-777 (2003).

Ikewaki N, Yamada A, Inoko H. Microbiol Immunol. 47:775-783 (2003).

C9782 Cytotoxicity Test 125 TestsMeasures necrotic and membrane-compromised cells. 250 Tests

D0011 Dacarbazine 100 mgC6H10N6O FW 182.18 [4342-03-4] 1 gUsed in the treatment of malignant melanoma and sarcomas.Flaherty LE, Redman BG, Chabot GG et al. Cancer. 65:2471-2477 (1990).

D0025 DAGO 1 mgC26H35N5O6 FW 513.00 2 mg

5 mg

D0032 Daidzein (See page 14 for more information) 250 mgC15H10O4 FW 254.24 [486-66-8] 1 gAn isoflavone that inhibits metabolic activation of benzo[a]pyrene. An 5 g inhibitor of hydrogenperoxide production in 12-O-tetradecanoylphorbol-13-acetate

stimulated HL-60 cells.

Chae Y-H, Ho DK, Cassady JM et al. Chem.-Biol. Int. 82:181-193 (1992).

Giles D, Wei H. Nutr. Cancer 29:77-82 (1997).

D0033 Daidzin 1 mgC21H20O9 FW 416.38 [552-66-9] 5 mgA kudzu isoflavone. Demonstrates chemopreventive activities by inhibiting the bioactivation

of carcinogenic arylamines. Daidzin is also a potent inhibitor of human mitochondrial

aldehye dehydrogenase. Hammons et. al. Nutr. Cancer. 33: 46-52 (1999).

Keung WM, Vallee BL. Proc Natl Acad Sci U S A.90: 1247-51 (1993).

D0044 D-Ala-D-Ala 250 mgC6H12N2O3 Mol Wt: 160.17 [923-16-0]

D0253 Danazol 100 mgC22H27NO2 FW 337.46 [17230-88-5] 250 mgIt is a synthetic gonadotropin inhibitor which has preventive effects on 1 gestrogen-related endometrial carcinogenesis in mice. Danazol therapy has

also resulted in regression of established mammary carcinoma in rats.Niwa K, Hashimoto M, Morishita S et al. Cancer Lett. 158:133-9 (2000).

Peters TG, Lewis JD, Wilkinson EJ, Fuhrman TM. Cancer. 40: 2797-800 (1977).

NH

NCONH2

N=N - N(CH3)2

H-Tyr-D-Ala-Gly-N-Me-Phe-

Gly-OL

O

O

HO

OH

O

HO

HO

OH

HO

O O

OH

O

D-Ala-D-Ala

N

O

CH3 H

CH3 OH

H H

C CH

CH3

O

HOCH3

O

OH3C

H3C

H3C

OH

H

NH

O

H

HN

H3C

CH2

OH

O OH3C

OHOCH3O

HN

H3C

CH3

O

CH3

O

O

O

CH3

OH

O

O


D0353 Danofloxacin 500 mgC19H20FN3O3 FW 357.38 [112398-08-0] 1 gA synthetic fluoroquinone with broad spectrum anti-bacterial activity. Used as a 5 g veterinary treatment of respiratory diseases in cattle, swine and chickens.Escudero, E. Journal of Veterinary Pharmacology and Therapeutics (2007), 30(6), 572-577.

Cox, S. K. Journal of Veterinary Pharmacology and Therapeutics (2007), 30(5), 381-386

D0254 Dansyl-Y-V-G 25 mgC28H34N4O7S FW 571.63 50 mg

125 mg

D0255 Dantrolene sodium 100 mgC14H9N4NaO5

.31/2H2O FW 399.29 [24868-20-0] 250 mgA skeletal muscle relaxant that inhibits intracellular calcium release. It has 1 g shown inhibitory effects on G6PD activity both in vitro and in vivo, in

addition to showing antioxidant effects.Beydemir S, Gulcin I, Kufrevioglu OI et al. Pol J Pharmacol. 55:787-92 (2003).

Buyukokuroglu ME, GulcIn I, Oktay M et al. Pharmacol Res. 44:491-4 (2001).

Tanii H, Taniguchi N, Tsujio I et al. Psychiat Clin Neuros. 51:415-9 (1997).

D0262 Dapiprazole Hydrochloride 10 mgC19H24ClN5 FW 357.89 [72822-13-0] 25 mgAn alpha blocker given as eye drops to reverse mydriasis. 100 mgAllinson RW et al. Ann. Ophthalmol. 22(4): 131-3, 138 (1990).

D0363 Daptomycin 25 mgC72H101N17O26 FW 1619.70 [103060-53-3] 100 mgA novel lipopeptide antibiotic used in the treatment of certain infections caused by

Gram-positive organisms. It is a naturally-occurring compound found in the soil

saprotroph Streptomyces roseosporus.

Fowler VG, Boucher HW, Corey GR. N. Engl. J. Med. 355 (7): 653–65 (2006).

D0169 Darifenacin Hydrobromide (See Page 21 for more info) 10 mgC28H31BrN2O2 FW 507.46 [133099-07-7] 25 mgIs a medication used to treat urinary incontenance. Mechanism of action is by 100 mgblocking the M3 musarinnic acetylcholine receptor.

Chapple, C. Current Medical Research and Opinion (2007), 23(10), 2347-2358.

Song P. Cancer research (2007), 67(8), 3936-44.

Naruganahalli, K. S. European Journal of Pharmacology (2007), 572(2-3), 207-212.

D0375 Dasatinib Monohydrate 25 mgC22H26ClN7O2S. H2O FW 506.02 [863127-77-9] 100 mgDasatinib Monohydrate is a dual BCR/ABL and Src family tyrosine kinases inhibitor. 500 mgDas J et al. (2006). J Med Chem 49 (23): 6819–32.

D0182 Daunorubicin Hydrochloride 10 mgDaunomycin 50 mgC27H29NO10

.HCl FW 564.0 [23541-50-6] 100 mgAn anthracycline antibiotic clinically used as an antitumor agent.

Effective against leukemia. It is an inhibitor of topoisomerase II and induces apoptosis

by intercalation into DNA.

Gieseler F, Nussler V, Brieden T et al. Int. J Clin Pharmacol Ther. 36:25-8 (1998).

Ferraro C, Quemeneur L, Prigent AF. Cancer Res. 60:1901-7 (2000).

Hande K. R. Biochim Biophys Acta 1400:173-84 (1998).

D1621 Deferasirox 25 mgC21H15N3O4 FW 373.63 [201530-41-8] 100 mgAn iron chelator capable of chelating 1atom of iron with every 2 molecules forming 250 mga 1:2 complex.

Heinz, U, Hegetschweiler, K., Acklin, P, et.al. Angew. Chem. Int. 38, 2568-2570 (1999).

Yang, L..P., Keam, S.J., Keating, G.M. Drugs 67, 2211-2230 (2007).

O

O

OH

OHCH3O

COCH3

OH

O

OH3C

HO

NH2.HCl

Dansyl-Tyr-Val-Gly

N

OH

OO

F

N

N

H3C

N NN

NN

HCl

HN

ClO

S

N

NH

NN

NN OH

H2O

OH2N

N

O

HBr

NH

O

NH

O

NH

CONH2

O

HN

COOH

NH

ONHO

O O

NH

O

NH2

OHN

HO O

O

NH

HO

O

NH

O

HN

HOOC

O

NH

OHN

HOOC

+H3N

NH

O

O

O2NO

N N

NH

O

O

P(O2Ca)O

O


D1624 Deflazacort 100 mgC25H31NO6 FW 441.52 [14484-47-0] 250 mgA glucocorticoid with anti-inflammatory and immunosuppressive activities. 1 g Deflazacort is a treatment of various muscle disorders, with the benefit of inducing less bone loss compared to prednisone. Schiatti P, Selva D, Barone D, Restelli A, Glasser A. Arzneimittelforschung. 30:1543-9 (1980).

Rizzato G, Fraioli P, Montemurro L. Chest. 99:301-9 (1991).

D1627 Dehydrocostus Lactone 5 mgC15H18O2 FW 230.3 [477-43-0] 10 mgInhibits NF-Kappa-B activiation by preventing TNF-alpha induced degradation 25 mgand phosphorylation. Renders HL-60 cells susceptible to TNF-alpha induced apoptosis

by enhancing caspase3 and caspase8 activities.Loizzo, M. Anticancer Research (2007), 27(5A), 3293-3300.

Jeong, Gil-Saeng. European Journal of Pharmacology (2007), 565(1-3), 37-44.

D1629 Dehydroepiandosterone 5 gDHEA 25 gC19H28O2 FW 288.42 MP: 149-151oC [53-43-0] 100 gA broad-spectrum cancer chemopreventive agent. A potent inhibitor

of glucose-6-phosphate dehydrogenase.

Schwartz AG, Pashko LL. J. CellBiochem.Suppl. 17G:73-79 (1993).

D1628 5,6-Dehydrokawain 5 mgC14H12O3 FW 228.25 [1952-41-6] 10 mgOne of the six main active ingredients (a-pyrones) of kava kava, found to have

antiplatelet activity which is due to the inhibition of thromboxane A2 formation.Teng CM, Hsu SY, Lin CH et al. Chin J Physiol 33:41-8 (1990).

D1643 Delta Sleep Inducing Peptide 1 mgC35H48N10O15 FW 848.83 [9431-45-4] 2 mgA neuropeptide found in neurons, peripheral organs and plasma. It induces 5 mgsleep in mammals with antistress and antihypoxic effects in rats.

Boglepov et. al. Morfologiia. 123:15-50 (2003).

Dovedova EL, Khrustalev DA, Khudoerkov RM. Bull Exp Biol Med. 140:514-6 (2005).

D1644 Deltorphin 1 5 mgC37H52N8O10 FW 768.87 [122752-15-2] 10 mgA high potency opioid neuropeptide isolated from amphibian skin. 25 mgStefano GB, Melchiorri P, Negri L et al. Proc Natl Acad Sci USA. 89:9316-20 (1992).

D1748 Demeclocycline Hydrochloride 100 mgC21H21ClN2O8

.HCl FW 501.30 [64-73-3] 250 mgA tetracycline antibacterial that has antimalarial activity. 1 gKumar A, Dutta GP. Ann Trop Med Parasit. 83:199-206 (1989).

D1749 Demecolcine 1 mgC21H25NO5 FW 371.43 [477-30-5] 5 mgInhibitor of spindle fiber formation in the M phase cell cycle. Induces 10 mgapoptosis in V79 cells. 50 mgFujikawa-Yamamoto K, Teralka K, Zong ZP et al. Cell Struct Funct.19:391-6 (1994).

D1849 4'-Demethylepipodophyllotoxin 500 mgC21H20O8 FW 400.38 [6559-91-7] 1 gA derivative of the antitumor agent VP-16-213 in the podophyllotoxin family. 5 gVan Maanen JM, van den Akker E, de Vries J et al. Eur J Cancer Clin Oncol. 24:1415-9 (1988).

HO

O

CH3O

CH3O

CH3O

O

OCH3

NHCH3

O

OCH3

O

Cl

OH O OH O

OH

NH2

O

OH

H H

N

OH

H3C CH3

.HCl

H-Trp-Ala-Gly-Gly-Asp-Ala-

Ser-Gly-Glu-OH

Tyr-D-Ala-Phe-Asp-Val-Val-

Gly-NH2

O

H2C

H2C CH2

O

H

HH

H

O

N

O

CH3

HOH3C

O

O

O

CH3

CH3

P(O2Ca)O

O


D1757 L-Deoxyalliin 1 gS-Allyl-L-cysteine 5 gC6H11NO2S FW 161.22 [21593-77-1]A water soluble organosulfur compound from garlic. It is a candidate for

chemoprevention clinical trial.Sumiyoshi H, Wargovich M. J. Cancer Res. 50:5084-5087 (1990).

Kelloff GJ et al. J.Cell.Biochem.Suppl. 26:1-28 (1996).

D1859 2-Deoxy-D-glucose 1 gC6H12O5 FW 164.16 [154-17-6] 5 gIt is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so 25 gthat it cannot undergo further glycolysis. Glucose hexokinase traps this substance in

most cells (with exception of liver and kidney) so that it makes a good marker for

tissue glucose use and hexokinase activity.

Pelicano H, Martin DS, Xu RH, Huang P. Oncogene 25:4633–4646 (2006).

D1759 Deoxynivalenol 1 mgC15H20O6 FW 296.32 [51481-10-8] 5 mgA Fusarium mycotoxin found in cereals, grains, and foodstuffs that can increase the

frequency of stillborn piglets by inhibiting protein synthesis.

Kamimura H, Nishijima M, Yasuda K et al. J Assoc Off Anal Chem. 64:1067-1073 (1981).

Diaz-Llano G, Smith TK. J Anim Sci. 84:2361-2366 (2006).

D1760 Deoxynivalenol, 3-Acetyl- 1 mgC17H22O7 FW 338.45 [50722-38-8] 5 mgDeoxynivalenol, 3-acetyl (3ADON) is derived from Fusarium graminearum.

It is a natural, Type B trichothecene mycotoxin.

Bretz M, Beyer M, Cramer B, Humpf HU. Mol Nutr Food Res. 2006 Mar;50(3):251-60

D1761 Deoxynivalenol, 15-acetyl- 1 mgC17H22O7 FW 338.35 [88337-96-6] 5 mgIt is derived from Fusarium graminearum. It is a natural, type B trichothecene mycotoxin.

D0368 Deoxysarcophine, 2-epi-16- (See page 22 for more info) 10 mgC20H30O2 FW 302.45It is a useful template for synthesis of a more active cancer chemopreventive agents. Several

studies were carried out in order to optimize its anticancer potential.

Sawant, S. S. Youssef, D. T. A. Reiland, J. and Ferniz, M. et. al. J. Nat. Prod. 691010-1013 (2006).

El Sayed,K.A. Hamann. M.T.Waddling,C.A.Jensen, C. and Lee, S. K. et. alJ.Org.Chem.637449-7455(1998).

Katsuyama, I. Fahmy, H. Zjawiony, J. K. Khalifa, S. I. And Kilada, R. W.et.alJ. Nat.Prod.651809-1814(2002).

Sawant, S. S. Sylvester, P. W. Avery, M. A. and Desai, P. et. al. J. Nat. Prod. 672017-2023 (2004).

D1768 Dermaseptin I 0.5 mgC152H257N43O44S2 FW 3455.08 1 mgA 34-amino acid residue cationic antimicrobial peptide. 2.5 mgAmmar B, Perianin A, Mor A et al. Biochem Biophys Res Commun. 247:870-5 (1998).

D1767 Dermenkephalin 1 mgC44H62N10O10S2 FW 955.17 2 mg

5 mg

D1769 Dermorphin 1 mgC40H50N8O10 FW 802.88 [77614-16-5] 2 mgA naturally occurring heptapeptide. It is a µ-selective opioid agonist with 5 mgpotent analgesic effects.Melchiorri P, Negri L. Gen Pharmacol. 27:1099-107 (1996).

Fontani G, Vergnani L, Salvadori S et al. Life Sci. 52:323-8 (1993).

Ala-Leu-Trp-Lys-Thr-Met-Leu-

Lys-Lys-Leu-Gly-Thr-Met-Ala-

Leu-His-Ala-Gly-Lys-Ala-Leu-

Gly-Ala-Ala-Ala-Ala-Asp-Thr-

lle-Ser-Gln-Gly-Thr-Gln

H-Tyr-D-Met-Phe-His-Leu-

Met-Asp-NH2

Tyr-D-Ala-Phe-Gly-Tyr-Pro-

Ser-NH2

O

O

CH3

CH3

CH3

CH3

O

O

H3C

OH

H

CH3

O OH

HO

H

OO

O

O

OH

OH

O

O

O

H

HO

OH

H

O

O

O

O OH

OH

HO

OH

P(O2Ca)O

O


D1770 Dermorphin Analog 5 mgC44H59N11O10 FW 902.03 10 mg

25 mg

D1774 Desloratadine 100 mgC19H19ClN2 FW 310.82 [100643-71-8] 500 mgA non-sedating H1-receptor agonist free from antimuscarinic/anticholinergic 1 geffects. It has novel anti-allergic and anti-inflammatory effects.Monroe EW. Skin Therapy Lett. 7:1-2, 5 (2002).

Henz BM. Allergy. 56 Suppl 65:7-13 (2001)

D1775 Deslorelin Acetate Please inquireC64H83N17O12 FW 1282.47 [57773-65-6]Deslorelin acetate is a potent LHRH agonist. Induction of ovulation in mares.

D1776 Desmopressin 1 mgMinirin 2 mgC46H64N14O12S2 FW 1069.1 [16679-58-6] 5 mgA hemostatic agent with strong vasodilatory effects.Kaufmann JE, Iezzi M, Vischer UM. J Thromb Haemost. 1:821-8 (2003).

D1777 Desmopressin Acetate 1 mgC46H64N14O12S2 FW 1069.24 [16679-58-6] 2 mgDesmoressin acetate is a synthetic analogue of vasopressin with low vasopressor activity. 5 mg Used in the treatment of nocturnal enuresis, central diabetes insipidus, polyuria, polydipsia

mild and moderate forms of hemophilia A and von Willebrand disease.

D1873 Desoxypeganine hydrochloride 25 mgC11H12N2

.HCl.2H2O FW 172.23 [61939-05-7] 100 mgAcetylcholinesterase inhibitor. It is used in the treatment of Alzheimer's dementia.

Tuliaganov N, Sadritdinov FS, Suleimanova GA.Farmakol Toksikol. 49:37-40 (1986).

Lockhart B, Closier M, Howard K et al. Naunyn Schmiedebergs Arch Pharmacol. 363:429-38 (2001).

D1693 Dexamethasone 100 mgC22FH29O5 FW 392.50 m.p. 262-2640C [50-02-2] 500 mgA potent glucocorticoid found to inhibit pulmonary carcinogenesis. 1 gWattenberg LW. J.Cell.Biochem.Suppl. 22:162-168 (1995).

Wattenberg LW, Estensen RD. Cancer Res. 56:5132-5135 (1996).

D1694 Dexamethasone Acetate 100 mgC24H31FO6

.H2O FW 452.52 [55812-90-3] 500 mgA glucocorticoid found to be most effective in adjunctive treatment against 1 g acute bacterial meningitis and in patients with resistant multiple myeloma.

Chaudhuri A. Lancet Neurol. 3:54-62 (2004).

Dimopoulos MA, Anagnostopoulos A, Weber D. J Clin Oncol. 21:4444-54 (2003).

D1695 Dexamethasone Sodium Phosphate 100 mgC22H28FO8PNa2 FW 516.4 [2392-39-4] 500 mgA systemic corticosteroid. It induces apoptosis and inhibits sodium 1 g phosphate symporter. Used in the treatment of emetic effects of cancer therapy and epicondylitis.

Hayreh SS, Zimmerman B. Ophthalmology.110:1204-15 (2003).

Li GF, Chen JH, Yang J et al. Di Yi Jun Yi Da Xue Xue Bao. 24:11-4 (2004).

Chen Y, Chen XY. Ai Zheng. 21:498-503 (2002).

Cassileth PA, Lusk EJ, Torri S et al. Arch Intern Med.143:1347-9 (1983).

Dexibuprofen (See S(+) Ibuprofen)

O

HO OH

CH2O

HO

F

N

NHCl 2H2O

O

HO OH

CH2O

H3COCO

F

O

HO OH

CH2O

PO

F

O

NaO

NaO

HN

N

Cl

H-Tyr-D-Arg-Phe-Sar-Tyr-Pro-

Ser-NH2

Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-

Arg-Pro-NHEt

Map-Tyr-Phe-Gln-Asn-Cys-Pro-

D-Arg-Gly-NH2

(Disulfide bridge, Map1-Cys6)

c[Mpr-Tyr-Phe-Gln-Asn-Cys]-

Pro-D-Arg-Gly-NH2

P(O2Ca)O

O


D1792 Dextromethorphan Hydrobromide Hydrate 5 gC18H25NO.HBr.H2O FW 370.30 [6700-34-1] 10 gd-Form of Racemethorphan 50 gWidely used as a cough suppressant. New use includes its anticonvulsive and neuro-

protective properties. It was found to improve cerebral ischemia. A NMDA receptor agonist.

Tortella FC, Pellicano M, Bowery NG. Trends Pharmacol Sci. 10:501-7 (1989).

Choi DW, Peters S. Viseskul V. J Pharmacol Exp Ther. 242:713-20 (1987).

D3200 Diacetoxyscirpenol 1 mgC19H26O17 FW 366.41 [2270-40-8] 5 mgA mycotoxin belonging to the 12,13-epoxytrichothecene group. It is produced by

several Fusarium strains together with some other toxins such as T2 and HT2 toxins.

It has anticancer, antiproliferation, and apoptosis inducing properties.

Lee DH, Park T, Kim HW. Biol Pharm Bull. (4):648-654 (2006)..

Claridge CA, Schmitz H, Bradner WT. Cancer Chemother Pharmacol 2(3):181-182 (1979).

Craddock VM. IARC Sci Publ. (84):266-9 (1987).

D3303 Diacerein 50 mgC19H12O8 FW 368.29 [13739-02-1] 250 mgUsed for treating osteoarthritis. Interleukinn-1 inhibitor

Sanfelix-Gimeno G. Medicina clinica (2008), 130(12), 463-5.

Sharma A. Journal of the Indian Medical Association (2008), 106(1), 54-6, 58.

Diallyl disulfide (See Allyl disulfide)

D3201 Diallyl sulfide, 97% (See page 11 for more information) 25 mlAllyl sulfide 100 mlC6H10S FW 114.21 b.p. 1380C [592-88-1] d. 0.887A modulator of drug metabolizing enzyme P450 system and inducer of the phase II

detoxifying enzyme GST. Inhibitor of chemical-induced carcinogenesis in many tissues.

Yang CS, Chhabra S, Hong JY, Smith TJ. J Nutr. 131:1041S-5S (2001).

Wargovich MJ, Imada O, Stephens LC. Cancer Lett. 64:39-42 (1992).

Srivastava SK, Hu X, Zaren HA et al. Cancer Lett. 118:61-67 (1997).

D3202 Diallyl trisulfide (See page 11 for more information) 100 mgC6H10S3 FW 178.34 b.p. 44-460C (0.02 mm) [2050-87-5] 500 mgOne of many sulfur containing compounds from garlic and onion. Inducer of 1 g phase II detoxifying enzymes. It was found to inhibit tumorigenesis and suppress

tumor cell proliferation.

Sparnins VL, Barany G, Wattenberg LW. Carcinogenesis 9:131-134 (1988).

Sakamoto K, Lawson LD, Milner JA. Nutr Cancer. 29:152-6 (1997).

Hu X, Singh SV. Arch Biochem Biophys. 340:279-86 (1997).

D3301 Diaveridine 1 gC13H16N4O2 FW 260.29 [5355-16-8] 10 gA coccidiostat and antiprotozoal drug.

Ono-Ogata T, Ogino T, Nishikawa M et al. Environ Mol Mutagen. 39:43-8 (2002).

Yoshimura H. Mutat Res. 261:149-52 (1991).

D3302 Diaveridine HCl 1 gC13H16N4O2

.HCl FW 296.74 10 g

H3CO

H3CO

N

N NH2

NH2

H3CO

H3CO

N

N NH2

NH2

.HCl

S

O

O

O

O

O

O

OH

O

OH

O

O

OH

O

O

H

O

P(O2Ca)O

O


D3304 Dibenzoylmethane, 98% 10 g1,3-Diphenyl-1,3-propanedione 25 gC15H12O2 FW 224.25 [120-46-7] 100 gA minor constituent of licorice. It was found to inhibit mammary tumorigenesis and

lymphomas/leukemias in mice.

Lin CC, Lu YP, Lou YR et al. Cancer Lett. 168:125-32 (2001).

Huang MT, lou YR, Xie JG et al. Carcinogenesis 19:1697-700 (1998).

D3575 2,5-Di-tert-butyl-4-hydroxyanisole 1 gC15H24O2 FW 212.33 [1991-52-2] 5 gAn antioxidant.

D3208 Diclazuril 500 mgC17H10Cl2N4O2 FW 407.64 [101831-37-2] 1 gA benzenacetonitril anticoccidial that prevents toxoplasmosis and coccidiosis. 5 gLindsay, Dubey J. Parasitol. 86:164 (1999).

D3209 Diclofenac, Sodium Salt 10 gC14H10Cl2NNaO2 FW 318.13 [15307-79-6] 25 gA non-steroidal anti-inflammatory agent with potent 100 gchemopreventive activity.Hixson LJ, Alberts DS, Krutzsch M et.al. Cancer Epidemiol. Biomarkers Prev. 3:433-438 (1994).

Didanosine (See 2',3'-Dideoxyinosine)

D3212 2',3'-Dideoxycytidine 100 mgDDC, Zalcitabine 250 mgC9H13N3O3 FW 211.22 [7481-89-2] 500 mgAntiviral pyrimidine nucleoside analogue effective against HIV. When activated to its triphosphate,

it is incorpoated into DNA by HIV-1 reverse transcriptase, causing DNA chain termination

and viral replication.Anderson KS. Antivir Chem Chemother. 12 Suppl 1:13-7 (2001).

Broder S. Am J Med. 88:2S-7S (1990).

Akintonwa DA. Med Hypotheses. 57:249-5 (2001).

D3214 2',3'-Dideoxyinosine 1 mgDDI, Didanosine 5 mgC10H12N4O3 FW 236.23 [69655-05-6] 25 mgA potent anti-retroviral agent. Most effective in combination therapy for the

treatment of HIV and related lymphoma.

McKinney RE Jr, Cunningham CK. Curr Opin Pediatr. 16:76-9 (2004).

Cooper DA. J Int Assoc Physicians AIDS Care (Chic Ill). 1:15-25 (2002).

Wiernik PH. Semin Hematol. 38:27-31 (2001).

D3218 Diethylstilbestrol 1 gC18H20O2 FW 268.35 [56-53-1] 5 gSynthetic estrogen. Induces apoptosis in hormone-insensitive prostate 10 g cancer cells.

Robertson CN, Roberson KM, Padilla GM et al. J Natl Cancer Inst. 88:908-17 (1996).

D3320 Difenoconazole (See page 16 for more information) 5 gC19H17Cl2N3O3 FW 406.26 [119446-68-3] 10 gIncreases the production of isothiocyanates through metabolism of glucosinolates 100 gMondal, L. Pestology (2007), 31(10), 33-41.

ClCl

NH

CH2CO2- Na

+

N

N

O

NH2

O

H

H

H

H

H

H

HO

CH3CH2

CH2CH3

HO

OH

C

O

CH2 C

O

HN

N N

N

O

O

HO

OCH3

C(CH3)3

(CH3)3C

OH

Cl Cl N

N

NH

O

O

N

O

Cl

Cl

O

O

N

N N

P(O2Ca)O

O


D3223 Difloxacin HCl (See page 16 for more information) 5 gC21H19F2N3O3 FW 399.39 [98106-17-3] 25 gA quinolone antimicrobial antibiotic that may reverse drug resistance in 100 g human neuroblastoma cells.

Norris MD, Madafiglio J, Gilbert J et al. Med Pediatr Oncol. 36:177-180 (2001).

D3219 Diflubenzuron 10 gC14H9ClF2N2O2 FW 310.68 [35367-38-5] 25 gBenzoyl-urea insectiside, found to be a potent inhibitor of melanosome 100 g synthesis in mouse melanoma cells. It has also been shown to inhibit TCDD-induced

CYP1A1 expression in HepG2 cells.

Norman JO, Meola SM. Antimicrob Agents Ch. 23:313-6 (1983).

Ledirac N, Delescluse C, Lesca P et al. Toxicol Appl Pharm. 164:273-9 (2000).

D3322 Diflunisal 5 gC13H8F2O3 FW 250.20 [22494-42-4] 10 gA non steroidal anti-inflammatory analgesic that has unusually long duration 50 gof action. Recently, it was found to have anti-proliferative activity against colon adenocarcinoma cells.

Forbes JA, Beaver WT, White EH et al. JAMA 248:2139-2142 (1982).

Cannell GR, Vesey DA, Dickinson RG. Life Sci. 70:37-48 (2001).

D3420 3,4 Difluorobenzocurcumin 100 mgC28H22F2O6 FW 492.47 250 mgThe yelow pigment of tumneric is an antipromoter with antioxidant and anti- 1 ginflammatory activities. Inhibits lipoxygenase and cyclooxygenase. Induces apoptosis

at the promotion/progression stage of carcinogenesis.

Huang, M-T., Lysz, T., Ferraro, T., Abidi, T.F., Laskin, J.D., Conney, A.H. Cancer Res. 51:813-819 (1991).

Samaha, H.S., Kelloff, G.J., Steele, V., et al. Cancer Res. 57:1301-5 (1997).

D3221 Difluoromethylornithine 10 mgDFMO, Eflornitine 25 mgC6H12F2N2O2

.HCl.H2O FW 236.65 [66640-93-5]An irreversible inhibitor of ornithine decarboxylase. Carcinogenesis inhibitor,

induces apoptosis and has antiangiogenic activity.

Gupta S, Ahmad N, Marengo SR. Cancer Res. 60:5125-33 (2000).

Takahashi Y, Mai M, Nishiojka K. Int. J Cancer 85:243-7 (2000).

Meyskens FL Jr, Gerner EW. J Cell Biochem Suppl. 22:126-31 (1995).

D3429 Dihydrocytochalasin B 1 mgC29H39NO5 FW 481.62 [39156-67-7] 5 mgInhibits cellular motile processes such as membrane ruffling, axon growth cone activity,

blood clot retraction, cytoplasmic streaming, photodinesis, and cytokinesis.

Lin S, Lin DC, Flanagan MD. Proc Natl Acad Sci U S A. 75:329-333 (1978).

D3328 Dihydrokainic acid 10 mgC10H17NO4 FW 215.25 [52497-36-6] 25 mgThe saturated analogue of kainic acid. Reduction of the isopropylene side-chain destroys

the affinity to binding sites. It enhances the antitumor activity of doxorubicin presumably

acting as a glutamate transporter inhibitor.

London ED, Klemm N, Coyle JT. Brain Res. 192:463-476 (1980).

Sadzuka Y, Yamashita Y, Sugiyama T, Sonobe T. Cancer Letters. 179:157-163 (2002).

D3229 7,8-Dihydrokawain 5 mgC14H16O3 FW 232.28 [587-63-3] 10 mgOne of the six main active ingredients (a-pyrones) of kava kava.

O

OCH3

O

F

F

COOH

OH

F

F

NH

NH

OO

Cl

H2N CHF2

OH

O

H2N

HN

CH2COOHCH

COOH

CH3

H3C

H3C

CH2

OH

O

O

CH3

OH

H

HN

O

N

N

H3C

N

F

F

O

OH

O

P(O2Ca)O

O


D3227 Dihydromethysticin 5 mgC15H16O5 FW 276.28 [19902-91-1] 10 mgOne of the six main kavalactones (a-pyrones) found in kava kava. It exhibits neuroprotective and antinociceptive activity.Backhauss C, Krieglstein J. Eur J Pharmacol 215:265-9 (1992).

Jamieson DD, Duffield PH. Clin Exp Pharmacol Physiol 17:495-507 (1990).

D3228 Dihydromyristicin 100 mgC11H14O3 FW 194.23 [52811-28-6] 500 mgHydrogenated product of myristicin, a natural constituent of parsley. Inducer 1 g of glutathione S-transferase enzymes.Zheng G-q, Kenney PM, Lam LKT. J. Agri. Food Chem. 40:107-110 (1992).

D3331 α, β-Dihydroresveratrol 10 mg

C14H14O FW 230.26 [58436-28-5] 25 mga, b-Dihydro-3,4',5'-trihydroxystilbene 100 mgA natural phytoestrogen found ini red wine and a variety of plants. Potential

anti-cancer properties.

Ramirez-Galicia, G. Chemical Biology & Drug Design (2007), 70(2), 143-153

D3330 Dihydrotanshinone 10 mgC18H14O3 FW 278.30 25 mgIt is one of several active components of the medicinal herb 100 mgSalvia miltiorrhiza Bunge. It has antibacterial and antimutagenic activities. It

was found to down-regulate IL-12 production at the transcription level.Sato M, Sato T, Ose Y et al. Mutation. Res. 265:149-154 (1992).

Lee DS, Lee SH, Noh JG et al. Biosci. Biotech. Biochem. 63:2236-2239 (1999).

Kang BY, Chung SW, Kim SH et al. Immunopharm. 49:355-361 (2000).

D3231 1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-hydroxy-3- 5 mg(4-methoxy-phenyl)-propan-1-one 10 mgC17H18O6 FW 318.32One of the minor components of kava kava.

D3230 1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-hydroxy-3- 5 mgphenyl-propan-1-one 10 mgC16H16O5 FW 288.30One of the minor components of kava kava.

D3431 3,4-Dihydroxyphenyl Ethanol 10 mg3-Hydroxytyrosol 25 mgC8H10O3 FW 154.16 [10597-60-1] 100 mg3,4-Dihydroxyphenyl Ethanol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells.D'Angelo S, Ingrosso D et al. Free Radic Biol Med. 2005 Apr 1;38(7):908-19.

D3232 3,3'-Diindolylmethane (See page 11 for more information) 1 gC17H14N2 FW 246.31 [1968-05-4] 5 gInduces apoptosis in human MCF-7 cancer cells,independent of P53 pathway. 10 gGe X, YannaiS, Rennert G et al. Biochem Biophy Res Commun 228:153-158 (1996).

D3447 Diltiazem 1 gC22H26N2O4S FW 414.52 [42399-41-7] 5 gDiltiazem is a potent vasodilator, increasing blood flow and variably decreasing 10 g the heart rate via strong depression of A-V node conduction. Its pharmacological activity is somewhat similar to verapamil.

Porkin, Linda S, European Journal of Pharmacology (2008), 587(1-3), 118-123.

NH

NH

O

OCH3

OO

O

OH

HO OCH3

O OH

OCH3

OH

HO OCH3

O OH

O

O

CH3O

CH2CH2CH3

O

O

O

N

S

N

O

OAc

OMe

HO

OH

OH

OH

OHHO

P(O2Ca)O

O


D3348 11,12-Dimethoxydihydrokawain 5 mgC16H20O5 FW 292.33 10 mgOne of the minor components of kava kava.

D3351 4-Dimethylaminopyridine 10 gC7H10N2 FW 122.17 [1122-58-3] 25 gAn acylation catalyst that is more powerful than pyridine. It is used as a 100 gcoupling agent for the synthesis of peptides. Also found to be an effective cardiac inotropic agent in vitro.

Savage AO. Arch Int Pharmacod T. 273:262-76 (1985).

Wang SS, Tam JP, Wang BS et al. Int J Pept Prot Res. 18:459-67 (1981).

Fell V, Lee CR. J Chromatogr. 121:41-7 (1976).

1,1-Dimethylbiguanide Hydrochloride (See Metformin Hydrochloride)

D3353 Diminazene Aceturate 1 gC22H29N9O6 FW 515.52 [908-54-3] 5 gAn anti-trypanosomal and anti-protozoal drug. 25 gGilbert RJ. Brit J Pharmacol. 80:133-9 (1983).

Diack A, Moloo SK, Peregrine AS. Vet Parisitol. 70:13-23 (1997).

D3355 Diosgenin 5 gC27H42O3 FW 414.62 [512-04-9] 100 gA steroid sapogenin used in the semi-synthesis of cortisone, pregnenolone and

progesterone. The unmodified steroid has estrogenic activity and can reduce the

level of serum cholesterol.

Chiang, Chun-Te. FEBS Letters (2007), 581(30), 5735-5742.

Dias K. European journal of pharmacology (2007), 574(2-3), 172-8.

D3356 Diosmetin 1 gC16H12O6 FW 300.26 [520-34-3] 5 gA natural flavonoid that inhibits human CYP1A enzyme activity. Diosmetin 25 g has anti-mutagenic and anti-allergic characteristic.

Huang MT, Wood AW, Newmark HL et al. Carcinogenesis. 4:1631-7 (1983).

Cheong H, Ryu SY, Oak Mh et al. Arch Pharm Res. 21:478-80 (1998).

D3357 Diosmin 1 gC28H32O15 FW 608.54 [520-27-4] 5 gA natural flavonoid that has anti-inflammatory and chemopreventive effects. 25 g It was found to inhibit chemical carcinogenesis in the bladder, esophagus and colon.

Crespo M E, Galvez J, Cruz T et al. Planta Med. 65:651-3 (1999).

Yang m, Tanaka T, Hirose Y et al. Int J Cancer. 73:719-24 (1997).

Tanaka T, Makita H, Kawabata K et al. Carcinogenesis. 18:761-9 (1997).

D3462 Diphenhydramine hydrochloride 10 gAllergina 25 gC17H21NO.HCl FW 291.82 [147-24-0] 100 gH1 histamine receptor antagonist was found to inhibit tumor promotion.

Fischer SM, Patrick KE, Patamalai B, Slaga TJ. Carcinogenesis. 11:991-6 (1990).

D3261 Dipropyl disulfide 25 gPropyl disulfide 100 gC6H14S2 FW 150.31 b.p. 195-1950C [629-16-6]An inhibitor of BP-induced forestomach cancer in mice.Srivastava SK, Hu X, Zaren HA et al. Cancer Lett 118: 61-67 (1997).

SS

HOO

OH

OCH3

OH O

OOH

CH3

OH OH

O CH2

O

OH

OH

OH

OO

OH

OCH3

OH O

O

OCH3

O

CH3O

CH3O

N

N

H2N

NH

NH

N

N

NH2

NH

HOOC NH

CH3

O

2

.

O

N

CH3

CH3

.HCl

O

HO

O

P(O2Ca)O

O


D3262 Dipropyl sulfide (See page 11 for more information) 10 gPropyl Sulfide 25 gC6H14S FW 118.24 b.p. 142-1430C [111-47-7]An inhibitor of BP-induced forestomach cancer in mice.Srivastava SK, Hu X, Zaren HA et al. Cancer Lett 118:61-67 (1997).

D3362 Dipyridamole 1 gC24H40N8O4 FW 504.63 [58-32-2] 5 gA cardiovascular drug that has antitumor properties. Inducer of FAT/CD36 25 gmobilizing branch. An effective antiplatelet agent.

Luiken JJ, Coort SL, Willems J et al. Mol Pharmacol. 65:639-45 (2004).

Boyer CR, Karjian PL, Wahl GM at al. Anticancer Drugs. 13:29-36 (2002).

D3372 Disodium Cycloheptylaminomethylene diphosphonate 25 mgC8H17NNa2O6P2 FW 331.15 [138330-18-4] 100 mgtreatment of bone disorders inhibit squalene synthase and cholestrol biosynthesis 250 mgAmin, Dilip, Journal of Lipid Research (1992), 33(11), 1657-63.

D3374 Disulfiram 50 gTetraethylthiuram disulfide 100 gC10H20N2S4 FW 296.54 [97-77-8] 250 gAn anti-carcinogen and DIG1 inducer. Widely used in avoidance therapy for alcohol abuse

and has protective effects against chemically-induced toxicity and carcinogenesis.

It exerts its chemopreventive effect by inhibiting metabolism of carcinogenes. It also

induces apoptosis.

Brady JF, Xiao F, Wang MH, Li Y et al. Toxicol Appl Pharmacol. 108: 366-73 (1991).

Proc. Am Assoc Cancer Res. 38:A3879 (1997).

Liu GY, Frank N, Bartsch H, Lin JK, Molecular Carcinogenesis. 22:235-46 (1998).

D0010 3H-1,2-dithiole-3-thione 25 mgD3T 100 mgC3H2S3 FW 134.25 [534-25-8] 500 mgA potent antioxidant that has chemopreventive properties. It is known to inducedetoxication enzymes and inhibit chemically-induced tumors in multiple tissues.Otieno MA, Kensler TW, Guyton KZ. Free Radic Biol Med. 28:944-52 (2000).

D4802 17-DMAG 1 mg17-Dimethyaminoethylamino-demethoxygeldanamycin 5 mgC32H48N4O8 FW 616.75 [467214-20-6] 10 mgA novel heat shock protein 90 inhibitor that enhances radiosensitization of MiaPaCa tumor cells.

Chatterjee M, Jain S, Stuhmer T et al. Blood 109: 720-728 (2007).

Dote H, Burgan WE, Camphausen K, Tofilon PJ. Cancer Res. 66:9211-9220 (2006).

D4873 DMSA (Meso-2,3-dimercaptosuccinic acid) 1 gSuccimer 5 gC4H6O4S2 FW 182.22 [304-55-2] 25 gA water soluble chelating agent found to exert a hypotensive effect in

cultured vascular smooth muscle cells (VSMCs) from rat aorta.

Kramer HJ, Mensikova V, Backer A et al. Biochem Pharmacol. 65:1741-6 (2003).

Vineeta N, Singh V, Makkar S. J Indian Soc Pedom Prev Dent. 19:160-3 (2001).

D5607 Dobutamine Hydrochloride 10 mgC18H23NO3HCl FW 337.85 [49745-95-1] 50 mgInotropic agent useful in a non-invasive approach for evaluating subclinical 100 mganthra-cycline cardiotoxicity.Cottin Y, L'huillier I, Casasnovas O et al. Eur J Echocardiogr. 1:180-3 (2000).

Subhedar NV, Shaw NJ. Cochrane Database Syst Rev. 3:CD001242 (2003).

S

CH3CH2

N

CH3CH2

C

S

S

CH2CH3

N

CH2CH3

C

S

S

S

S

S

H

H

N

N

N

N

N

N

N

N

HO

OH

OH

HO

HO

HO

N

OH

CH3

HCl

OH

OH

HS

HS

O

O

HN

PO3HNa

PO3HNa

NH

HN

N

O O

O

HO

O O

OO

H2N

P(O2Ca)O

O


D5709 Docetaxel 5 mgC43H53NO14 FW 807.89 [114977-28-5] 10 mgA derivative of paclitaxel. Microtubule inhibitor. Induces apoptosis and 25 mg inhibits angiogensis.

Wang, T.H., Wang, N.R., Mason, K.A., Milas, L. Mund-, Kiefer- und Gesichtschirurgie. 3:210-2 (1999).

Matsuura, M., Hasegawa, M., Hayakawa, K et al. Oncol Reports. 7:289-93 (2000).

D5612 2-n-Dodecylfuran 1 gC16H28O FW 212.38 [75308-12-2] 5 gDerivative of heterocyclic organic compound, Furan. 10 g

D5746 Dolasetron 5 mgC19H20N2O3 FW 324.37 [115956-12-2] 25 mgAn antiserotonin used as an antiemetic to prevent nausea and vomiting 100 mg brought on by general anaesthesia or chemotherapy.Hesketh PJ, Gandara DR, Hesketh AM et al. Support Care Cancer. 4:141-146 (1996).

Fujii Y. Clin Drug Investig. 26:427-437 (2006).

D5649 Domperidone 50 mgC22H24ClN5O2 FW 425.91 [57808-66-9] 250 mgA potent inotropic agent. Effective against interleukin 2 induced hypotension. 1 gSubhedar NV, Shaw NJ. Cochrane Database Syst Rev. CD001242 (2003).

Zeilender S, Davis D, Fairman RP, Glauser FL. Cancer Res. 49:4423-6 (1989).

D5753 Donepezil Hydrochloride 25 mgC24H29NO3

. HCl FW 415.95 [120011-70-3] 100 mg

It is a centrally acting reversible acetylcholinesterase inhibitor. Its main therapeutic 500 mguse is in the treatment of Alzheimer's disease.

Sugimoto H, Ogura H, Arai Y. Japan. J Pharamacol. 89:7-20 (2002).

D5662 Dopamine Hydrochloride 5 gC8H11NO2

.HCl FW 189.64 [62-31-7] 25 gA vasopressor that modulates cortical activation. It attenuates iNOS through 100 ga D(1), beta1&2 adrenergic receptor-linked adenylate cyclase-mediated cAMP cascade.Ashby FG, Casale MB. Neural Netw. 16:973-84 (2003).

Mazzio E, Becker A, Soliman KF. J Neuroimmunol.131:70-82 (2002).

D5868 Doramapimod 10 mgC31H37N5O3 FW 527.66 [2859873-48-4] 25 mgA pyrazole phenyl urea derivative is a reversible, competitive inhibitor of p38 MAP 100 mgkinase. It interferes with ATP binding of p38. It also blocks tumor necrosis factor-alpha

and IL-1β synthesis.

Pargellis, C., Tong, L., Churchill, L., et al. Nat. Struct. Biol. 9, 268-272 (2002).

D5869 Doripenem hydrate 10 mgC15H24N4O6S2 H2O FW 438.52 [364622-82-2] 25 mgIt is a broad spectrum antibiotic belonging to the class of antibiotics called 100 mgcarbapenems. It Inhibits bacterial cell wall synthesis and causes cell death by binding

to and inactivating penicillin-binding proteins (PBPs).

Paterson, D.L., DePestel, D.D. Clin. Infect. Dis. 49:291-298 (2009).

Jones, R.N, Huynh, H.K. Biedenbach, D.J, et.al J. Antimicrob. Chemother. 54:144-154 (2004).

D5992 Doxapram Hydrochloride Hydrate 25 mgC24H30N2O2

.HCl.H2O FW 432.98 [7081-53-0] 100 mgStimulates chemoreceptors in the carotid arteries, which in turn, stimulates the 500 mgrespiratory center in the brain stem.

Lugliani R, Whipp BJ, Wasserman K. Chest 76:414-419 (1979).

O

OH

O CH3

O

H

OH

OO

O

O

OH

HO O

3'2'

1'

19

17 20

18

1612

15

14

13

11 10 9

87 6

54

3

21HN

CO

O

C

CH3

CH3

H3C

NH

N

O

N

N

NH

Cl

O

HO

HO

NH2

HCl

O (CH2)11CH3

NO

O

O

NH

O

N

N

O

CH3HClH2O

P(O2Ca)O

O


D5690 Doxazosin Mesylate 50 mgDoxazosin methanesulfonate 250 mgC23H25N5O5

.CH3SO3H FW 547.59 [77883-43-3] 1 gAn alpha-blocker drug. It reduces progression of benign prostatic hyperplasia.

McConnell JD et al. N Engl J Med. 349:2387-98 (2003).

Stafford RS, Furberg CD, Finkelstein SN et al. JAMA. 291:54-62 (2004).

D5692 Doxifluridine 50 mgC9H11FN2O5 FW 246.19 [3094-09-5] 100 mgA prodrug of 5-FU converts to the active antitumor agent by pyrimidine nucleoside

phosphorylase. Has remarkable antitumor activity in human colorectal and advanced

gastrointestinal cancer.

De Cesare, M. Pratesi, G. De Braud, F., et al Anticancer Res. 14:549-54 (1994).

Di Bartolomeo M, Bajetta E, Somma L, Buzzoni R. Tumori. 81:147-50 (1995).

D5792 Doxofylline 1 gDoxophylline 5 gC11H14N4O4 FW 266.25 [69975-86-6] 25 gA novel xanthine bronchodilator known to inhibit phosphodiesterase activities.

Dini FL, Cogo R. Curr Med Res Opin. 16:258-68 (2001).

D5794 Doxorubicin Hydrochloride 5 mg14-Hydroxydaunomycin 10 mgAdriamycin 50 mgC27H29NO11

.HCl FW 580.0 [25316-40-9]An anthracycline antibiotic clinically used for chemotherapy of malignant tumors,

particularly solid tumors by acting on DNA topoisomerase II.

Giuliani FC, Liu LF, Israel M et al. Cancer Res. 49:5969-78 (1989).

Wasserman K, Markovits J, Jaxel C. Mol Pharmacil 38:38-45 (1990).

D5897 Doxycycline Hyclate 1 gDoxycycline hydrochloride hemiethanolate hemihydrate 5 gC22H24N2O8

.HCl.1/2(H2O).

1/2(C2H6O) FW 512.9 [24390-14-5] 10 gAn antimicrobial agent. Used in the treatment of severe purulent inflammatory 25 gdiseases such as pneumonia, lung abscesses, pyothorax, skin and soft tissue

infections, peritonitis, purulent cholangitis and others.

Barkhordar RA, Russel T. J Calif Dent Assoc. 26:842-5 (1998).

Pozdniakova VP et al. Antibiot Khimioter. 37:43-6 (1992).

D5898 Doxycycline Monohydrate 1 gC22H24N2O8

.H2O FW 462.45 [17086-28-1] 5 gDoxycycline is a synthetic teracycline. Inhibits angiogenesis in a quantitative 10 g in vitro assay of angiogeneis. Inhibits proliferation of the human leukemia cell 25 gline K562. It reduces lung metastases by inhibiting the secretion and acitivity

of matrix metalloproteinases (MMPs).

Fife RS, Sledge GW Jr, Sissons S, Zerler B. Cancer Lett. 153:75-8 (2000).

Kasono K et al. Cancer Gene Ther. 7:151-9 (2000).

Lokeshwar BL. Ann NY Acad Sci. 878:271-89 (1999).

D6957 Droloxifene 25 mg3-Hydroxytamoxifen 100 mgC26H29NO2 FW 387.51 [82413-20-5] 250 mgIs a phenolic analog of tamoxifen which is undergoing clinical trial for the

treatment of metastatic breast cancer.

Qin, Z. Journal of Medicinal Chemistry (2007), 50(11), 2682-2692.

O

O

OH

OHCH3O

COCH2OH

OH

O

OH3C

HO

NH2.HCl

N

HN

O

H

OH

CH3

H

O

F

O

H

OH

H

N

NH3CO

H3CO

NH2

N

N

O

O

O

CH3SO3H

N

NN

N O

O

O

H3C

O

CH3

OH O OH O

CONH2

OH

OH

N(CH3)2

H

OH

H

CH3H H H

.HCl.1/2H2O.1/2(C2H6O)

H3C

ON

CH3

CH3

OH

P(O2Ca)O

O


D6958 Droloxifene citrate 25 mgC26H29NO2

. C6H8O7 FW 579.64 [97752-20-0] 100 mgAn anti-tumor agent, particularly for treatment and prevention of cancer of the breast. 250 mgDroloxifene is also useful for the relief of bone diseases.

Chen Y, Xia P, Zhang Q, et al. Yao Xue Xue Bao 35:902-905 (2000).

D7992 DTX-4 25 µgC66H104O30S3 FW 1473.90 DTX 4 is a precursor to okadaic acid produced by Prorocentrum lima. DTX 4 is

inactive both in vitro and in vivo and may serve as a water-soluble, non-toxic storage

form of okadaic acid. Sold by LKT under license from the manufactuer, MARBIONC.

Hu, T. et al. J. Chem. Soc. Chem. Commun. (1995) , 597–599

Windust, A. J. et al. Toxicon (1997) 35, 1591–1603

D8014 DU-14 5 mgC22H38N2O4S FW 426.6 [186303-55-9] 25 mgInhibits steroid sufatase. Enhances learning and spatial memory in rats.

Inhibits proliferation of human MCF-7 breast cancer cells.

DA Johnson et al Brain Res. 2000 865:286.

KW Selcer et al Cancer Res. 1997 57:702.

E0403 Ebastine 1 gC32H39NO2 FW 469.66 [90729-43-4] 5 gA non-sedating histamine H1 receptor antagonist that also inhibits T cell migration and may

find a use in the treatment of Th2-type autoimmune diseases.

Roberts DJ. Drugs. 52 Suppl 1:8-14 (1996).

Nori M, Iwata S, Munakata Y et al. Clin Exp Allergy. 33:1544-1554 (2003).

E0073 Ebselen 5 mgC13H9NOSe FW 274.18 [60940-34-3] 25 mgA seleno-organic compound showing glutathione peroxidase-like activity that has

anti-inflammatory, anti-oxidant, and anti-malarial effects. It has been shown to inhibit

NO-induced apoptosis of differentiated PC12 cells and protect Ca2+ blockage.

Moretto MB, Franco J, Posser T et al. Neurochem Res. 29:1801-6 (2004).

Lindenblatt N, Schareck W, Belusa L et al. Thromb Haemostasis. 90:882-92 (2003).

Sarker KP, Biswas KK, Rosales JL et al. J Neurochem. 87:1345-53 (2003).

E0812 β-Ecdysone 1 mg(2b, 3b, 14a, 20, 22[R], 25-Hexahydroxy-7-cholesten-6-one) 5 mgC27H44O6 FW 464.63 [3604-87-3] 25 mgInsect development hormone that stimulates DNA synthesis in animal lymphocytes

activated by polyclonal mitogens.

Fomovskaia GN, Berdyshev AG, Kholodova ID. Ukr Biokhim Zh. 64:56-61 (1992).

E0813 Ecdysterone 5 mg20-Hydroxyecdysone 10 mgC27H44O7 FW 480.63 [5289-74-7] 25 mgA steroid hormone used as anobolic drug, found to induce apoptosis.

It modulates antitumor activity of cytostatics and biosynthesis of macromolecules.

Thummel CS. Insect Biochem Mol Biol. 32:113-20 (2002).

Buszczak M, Segraves WA. Curr Biol. 10:R830-3 (2000).

Konovalova NP, Mitrokhin IuI, Volkova LM et al. Izv Akad Nauk Ser Biol. 6:650-8 (2002).

E2424 Egg Laying Hormone of Aplysia 0.5 mgC190H329N59O57S1 FW 4384.17 [117680-39-4] 1 mg

2.5 mg

CH3

OH

CH3HO

OH

H

OHH

O

CH3

H

HO

HO

CH3

H3C

Se

N

O

H-Ile-Ser-Ile-Asn-Gln-Asp-Leu-

Lys-Ala-Ile-Thr-Asp-Met-Leu-

Leu-Thr-Glu-Gln-Ile-Arg-Glu-

Arg-Gln-Arg-Tyr-Leu-Ala-Asp-

Leu-Arg-Gln-Arg-Leu-Leu-Glu-

Lys-NH2

O

O

OH

O

O

OO

O

OH

O

O

OHHH

H

H

H

H

H

OH

O

O

OH

OSO3H

OH OH

OSO3H

OSO3H

H3C

ON

CH3

CH3

OH HO2C

HO CO2H

CO2H

NH

OO

SH2N

O

O

P(O2Ca)O

O


E4408 Elcatonin Acetate Please inquireC148H244N42O47 FW 3363.8 [60731-46-6]

A synthetic eel calcitonin analogue. For the treatment of osteoporosis, paget’s disease and hypercalcemia.

E4416 Eledoisin 1 mgC54H85N13O15S1 FW 1188.44 [69-25-0] 2 mgA potent vasodilating peptide that increases vascular permeability. 5 mgSicuteri F, Michelacci S, Lombardi V, Fanciullacci M.Arch Int Pharmacodyn Ther. 151:3 8-40 (1964).

Saria A, Yan Z, Wolf G, Loidolt D, Martling CR, Lundberg JM. Acta Otolaryngol Suppl. 457: 25-8 (1989).

E4417 Eledoisin Related Peptide 5 mgC34H58N8O6S FW 706.96 10 mg

25 mg

E4419 Eletriptan Free Base 1 mgC22H25N2O2S FW 382.52 [143322-58-1] 5 mgused treatment of migraine headaches.

Spierings E L, Neurology (2000), 55(5), 735; author reply 736.

E4444 Ellagic acid 10 gC14H6O8 FW 302.20 m.p. >3000C [476-66-4] 50 gPolyphenol found in plants. Its precursors are ellagitannins commonly present in

grapes, pomegranates, raspberries, and strawberries. It is an inhibitor of Phase I enzymes,

an inducer of Phase II enzymes and an inhibitor of chemical carcinogenesis.Bate-SmithECInThePharmacologyofPlantPhenolicsFairbairn,J.W.,Ed.,AcademicPress:NY133-147(1959).

Mandal S, Shivapurkar N, Galati AJ, Stoner GD. Carcinogenesis. 9:1313-16 (1988).

Das M, Bickers DR, Mukhtar H. Carcinogenesis 6:1409-13 (1985).

Siglin JC, Barch DH, Stoner GD. Carcinogenesis 16:1101-1106 (1995).

E4902 Emamectin B1 Benzoate 100 mgC49H75NO13 FW 886.12 [137512-74-4] 250 mgAn avermectin pesticide. It has been shown to cause neurotoxicity in rats at 1 g high doses.

Wise LD, Allen HL, Hoe CM et al. Neurotoxicol Teratol. 19:315-26 (1997).

Hakalahti T, Lankinen Y, Valtonen ET. Dis Aquat Organ. 60:197-204 (2004).

E5057 Emodin 100 mgC15H10O5 FW 270.24 [518-82-1] 250 mgA purgative resin from Himalayan Rhubarn which displays inhibitory effects on 1 g the growth of various human hepatoma cell lines and stimulates the expression of p53 and p21.

Huang, X. Cancer Biology & Therapy (2008), 7(3), 468-475

Wu, Y. Life Sciences (2007), 81(17-18), 1332-1338.

E5202 Enalapril 1 gC20H28N2O5 FW 376.45 [75847-73-3] 5 gAn antihypertensive agent known to reduce the incidence of vascular dementia

and Alzheimer's disease. Found to have a potential for colon cancer prevention.

Frishman WH. Heart Dis. 4:380-6 (2002).

Yasumaru M et al. Cancer Res. 63:6726-34 (2003).

E5201 Enalapril Maleate (See page 25 for more information) 1 gC20H28N2O5

.C4H4O4 FW 492.52 [76095-16-4] 5 gAn angiotensin-converting enzyme inhibitor. It actively interferes with the renin-angiotensin-

aldosterone system.

Cleary JD, Taylor JW. Drug Intel Clin. Pharm. 20:177-186 (1986).

NH

N

OH3C O

O

HOOC

CH3

O

O O

O

O

O

O

OO

OCH3

HN

H3C

H

H3C

OCH3

H

H

OH

OH

H

H

CH3

CH2CH3

CH3

H

H3C

H3C

CH3

CH3

O

O

O

O

OH

OH

OH

HO

Ser-Asn-Leu-Ser-Thr-Asu-Val-

Leu-Gly-Lys-Leu-Ser-Gln-Glu-

Leu-His-Lys-Leu-Gln-Thr-Tyr-

Pro-Arg-Thr-Asp-Val-Gly-Ala-

Gly-Thr-Pro Ser----Asu

pGlu-Pro-Ser-Lys-Asp-Ala-Phe-

Ile-Gly-Leu-Met-NH2

H-Lys-Phe-Ile-Gly-Leu-Met-

NH2

HN

N

S

O

O

O

O

OH

H3C

OH

OH

P(O2Ca)O

O


E5200 Enalaprilat 10 mgC18H24N2O5

.2H2O FW 384.42 [84680-54-6] 50 mgThe active metabolite of enalapril. 100 mgShioya H, Shimojo M, Kawahara Y. Biomedical Chromatography 6:59-62 (1992).

E5210 Endomorphin-1 5 mgC34H38N6O5 FW 610.72 [189388-22-5] 10 mgAn endogenous µ-opioid receptor agonist which has potent analgesic and 25 mggastrointestinal effects.Somogyvari-Vigh, A. et al. Exp. Brain Res. 156:224 (2004).

Zadina, J. et al. Ann. NY. Acad. Sci. 897:136 (1999).

E5211 Endomorphin-2 5 mgC32H37N5O5 FW 571.68 [141801-26-5] 10 mg

25 mg

E5212 Endonuclease Antigenic Site 1 mgC108H167N27O29 FW 2307.67 2 mg

5 mg

E5214 α-Endorphin 1 mgC77H120N18O26S FW 1745.98 [61512-76-3] 2 mga-endorphin is 1-16 fragment of a-endorphin. It binds to neuronal opiate 5 mg receptors and has a stimulatory effect on immune system.Waterfield, A. A. Eur. J. Pharmacol. 58:11 (1979).

E5215 Acetyl, α-Endorphin 1 mgC79H122N18O27S FW 1788.02 2 mg

5 mg

E5216 α-Endorphin, camel 1 mgC155H250N42O44S FW 3438.04 2 mg

5 mg

E5217 α-Endorphin, human 1 mgC158H251N39O46S FW 3465.06 2 mg

5 mg

E5218 α-Endorphin, rat 1 mgC157H254N42O44S FW 3466.09 2 mg

5 mg

E5219 Endothelin-1, human 0.5 mgC109H159N25O32S5 FW 2491.95 1 mgIt is produced by endothelial cells, neurons and astrocytes in the central 2.5 mg nervous system, hepatocytes and Sertoli cells. It has an important role in the

paracrine regulation of cardiovascular functions in humans.

Yanagisawa, M. et al. Nature. 332:411 (1988).

E5221 Endothelin-2, human 0.5 mgC115H160N26O32S4 FW 2546.97 [123562-20-9] 1 mgMainly produced in the kidney and intestine. 2.5 mg

H-Tyr-Gly-Gly-Phe-Met-Thr-

Ser-Glu-Lys-Ser-Gln-Thr-

Pro-Leu-Val-Thr-Leu-Phe-

Lys-Asn-Ala-Ile-Ile-Lys-Asn-

Ala-His-Lys-Lys-Gly-Gln-OH


Ser-Glu-Lys-Ser-Gln-Thr-Pro-

Leu-Val-Thr-Leu-Phe-Lys-

Asn-Ala-Ile-Ile-Lys-Asn-Val-

His-Lys-Lys-Gly-Gln-OH

H-Tyr-Pro-Trp-Phe-NH2

H-Tyr-Pro-Phe-Phe-NH2

Glu-Thr-Gly-Gln-Glu-Thr-Ala-

Tyr-Phe-Leu-Leu-Lys-Leu-Ala-

Gly-Arg-Trp-Pro-Val-Lys



Leu-Val-Thr-OH

Ac-Tyr-Gly-Gly-Phe-Met-Thr-


Leu-Val-Thr-OH


Ser-Glu-Lys-Ser-Gln-Thr-

Pro-Leu-Val-Thr-Leu-Phe-

Lys-Asn-Ala-Ile-Ile-Lys-Asn-

Ala-Tyr-Lys-Lys-Gly-Glu-OH

H-Cys-Ser-Cys-Ser-Ser-Trp-

Leu-Asp-Lys-Glu-Cys-Val-Tyr-

Phe-Cys-His-Leu-Asp-Ile-Ile-

Trp-OH


H-Cys-Ser-Cys-Ser-Ser-Trp-

Leu-Asp-Lys-Glu-Cys-Val-Tyr-

Phe-Cys-His-Leu-Asp-Ile-Ile-

Trp-OH


P(O2Ca)O

O


E5222 Endothelin-3, human 0.5 mgC121H168N26O33S4 FW 2643.1 [117399-936] 1 mgMainly produced in the kidney and intestine. 2.5 mg

E5220 Enfuvirtide Acetate (T-20) 1 mgC204H301N51O64 FW 4462.0 [159519-65-0] 2 mgEnfuvirtide is an antiretroviral drug that is used to treat HIV. 5 mg

E5240 Leu-Enkephalin 25 mgC28H37N5O7 FW 555.62 [58822-25-6] 50 mgLeu-enkephalin has multiple effects on the central nervous system, including 125 mg the neuroendocrine hypothalamus. It is an endogenous agonist for the receptors that are stimulated

by opiate alkaloids.Dudás, B. and I. Merchenthaler et al. J. Clin. Endo. Met. 88:1842 (2003).

Zhang, N. et al. J. Biol. Chem. 278:12729 (2003).

E5241 Met-Enkephalin 25 mgC27H35N5O7S FW 573.67 [58569-55-4] 50 mg

125 mg

E2542 Met-Enkephalin, amide 10 mgC27H36N6O6S FW 572.69 [60117-17-1] 20 mg

50 mg

E5456 Enocitabine 25 mgC31H55N3O6 FW 565-78 [55726-47-1] 100 mgAnti-tumor agent with suspected anti-leukemia potential treatment. 250 mgMin, Woo-Sung. Hematological Oncology (2007), 25(2), 76-83.

Tsurumi, H. Journal of Cancer Research and Clinical Oncology (2007), 133(8), 547-553

Usuki, K. International Journal of Hematology (2007), 85(1), 59-69.

E5358 Enoxacin 500 mgC15H17N4O3F.

3/2H2O FW 320.32 [74011-58-8] 1 gQuinolone antibacteral agent. Acts on DNA gyrase.

Yoshida H. Nakamura M, Bogaki M et al. Antimicrob Agents Chemother 37:839-45 (1993).

Enoxolone (See 18 β-Glycyrrhetinic acid)

E5369 Enrofloxacin (See page 16 for more information) 5 gC19H22FN3O3 FW 359.39 [93106-60-6] 10 gA plant fungicide and antibacterial agent. 50 gSchroder J, J S Afr. Vet Assoc. 60:122-4 (1989).

E5575 Entacapone 25 mgC14H15N3O5 FW 305.29 [116314-67-1] 100 mgA catechol-O-methyltransferase inhibitor for the adjunctive treatment of Parkinson's disease. 500 mgNajib J. Clin. Ther. 23:802-832 (2001).

E5576 Entecavir 1 mgC12H15N5O3 FW 277.28 [142217-69-4] 5 mgAn antiviral agent used in the treatment of hepatitis B. 25 mgYurdaydin, C. Expert Opinion on Pharmacotherapy (2008), 9(17), 3095-3109.

H-Cys-Thr-Cys-Phe-Thr-Tyr-

Lys-Asp-Lys-Glu-Cys-Val-Tyr-

Tyr-Cys-His-Leu-Asp-Ile-Ile-

Trp-OH


CH3CO-Tyr-Thr-Ser-Leu-lle-His-

Ser-Leu-lle-Glu-Glu-Ser-Gln-Asn-

Gln-Gln-Glu-Lys-Asn-Glu-Gln-

Glu-Leu-Leu-Glu-Leu-Asp-Lys-

Trp-Ala-Ser-Leu-Trp-Asn-Trp-

Phe-NH2

NNN

NH

F

O

COOH

C2H5

. 3/2H2O

H-Tyr-Gly-Gly-Phe-Leu-OH

H-Tyr-Gly-Gly-Phe-Met-OH

H-Tyr-Gly-Gly-Phe-Met-NH2

N

N

HN (CH2)20CH3

O

O

OOH

OHHO

P(O2Ca)O

O


E5276 Enterostatin, human 1 mgC21H86N3O6 FW 496.57 [117830-79-2] 2 mgA pentapeptide released from the exocrine pancreas and gastrointestinal 5 mg tract that regulates fat intake. It possesses anti-analgesic activities.

Takenaka Y, Nakamura F, Usui H et al. Peptides. 24:735-9 (2003).

Lin L, Thomas SR, Kilroy G et al. Am J Physiol Regul Integr Comp Physiol. 285:R321-8 (2003).

E5277 Enterostatin, porcine, rat 1 mgC25H4N8O8 FW 582.66 2 mgA pentapeptide released from the exocrine pancreas and gastrointestinal tract that 5 mgregulates fat intake. It possesses anti-analgesic activities.Takenaka Y, Nakamura F, Usui H et al. Peptides. 24:735-9 (2003).

E5477 Entinostat (See page 30 for more information) 1 mgC21H20N4O3 FW 376.41 [209783-80-2] 5 mgA synthetic benzamide derivative with potential antineoplastic activity. Binds to and 25 mginhibits histone deacetylase, an enzyme that regulates chromatin structure and

gene transcription.Juergens RA, Vendetti F, Coleman B. J Clin Oncol 26:19036 (2008).

E6231 (-)-Epicatechin 1 mgC15H14O6 FW 290.27 [490-46-0] 5 mgNatural product from green tea.

E6232 (-)-Epicatechin gallate 1 mgC22H18O10 FW 442.37 [1257-08-5] 5 mgNatural product from green tea, induces apoptosis.

E6233 (-)-Epigallocatechin 1 mgC15H14O7 FW 306.27 [970-74-1] 5 mgNatural product from green tea.

E6234 Epigallocatechin gallate (See page 14 for more info) 25 mgEGCG 50 mgC22H18O11 FW 458.37 [989-51-5] 100 mgAn active component of tea for the chemoprevention of cancer. An antioxidant that

acts as an anti-promoter of carcinogenesis, inhibits angiogenesis and induces apoptosis.

Bhimani RS, Troll W, Grunberger D, Frenkel K. Cancer Res. 53:4528-4533 (1993).

Fujiki H, Suganuma M, Komori A et al. Cancer Detect. Prev.18: 1-7 (1994).

Dong Z, Ma W, Huang C, Yang CS. Cancer Res. 57:4414-4419 (1997).

E6432 (-)-Epinephrine 1 gAdrenalin; L-Adrenaline; L-Epinephrine 5 gC9H13NO3 FW 183.20 [51-43-4] 10 gA predominent neurotransmitter. Found to be effective beta2-agonist 100 g bronchodilator.King Vj et al.Arch Pediatr Adolesc Med.158:127-37 (2004).

Rosol TJ, Yarrington JT, Latendresse J, Capen CC..29:41-8 (2001).

E6235 Epirubicin hydrochloride 1 mg4'-Epidoxorubicin hydrochloride, Farmorubicin, pharmorubicin 5 mgC27H29NO11

.HCl FW 579.99 [56390-09-1] 10 mgAn analog of doxorubicin.

OH

H

O

OH

HO

C

O

OH

OH

OHOH

OH

OH

O

OH

H

H

HO

OH

HO

OH

O

OH

H

H

HO

OH

HO

OH

OH

HO

HO

HN

CH3

OH

Ala-Pro-Gly-Pro-Arg

Val-Pro-Asp-Pro-Arg

N

OHN

O

NH

O

NH2

P(O2Ca)O

O


E6259 Epoxiconazole (See page 16 for more information) 5 gC17H13ClFN3O FW 329.76 [106325-08-0] 10 gA pesticide which has been classified by the EPA likely to be carcinogenic to 100 g humans based on evidence of hepatic tumors.

Mazur, C. S. Environmental Science & Technology (2008), 42(3), 947-954.

E6470 Eprinomectin 100 mgB1a R=C2H5 C50H75NO14, B1b R=CH3 C49H73NO14 [133305-88-1] 250 mgAn insecticide commonly used as a topical anthelmintic. 1 gA mixture of B1a and B1b

Lespine A, Sutra JF, Dupuy J et al. Parasitol Res. 89:120-2 (2003).

Chartier C, Pors I. Vet Parasitol. 125:415-9 (2004).

E6376 Eptifibatide 5 mgIntegrilin 10 mgC35H49N11O9S2 FW 832.4 [188627-80-7] 25 mgA selective inhibitor of platelet glycoprotein IIb/IIIa receptors.

Plosker Gl, Ibbotson T. Pharmacoeconomics. 21:885-912 (2003).

E6781 (±)-Equol 10 mg(R,S)-Equol; 3,4-Dihydro-3,(4-hydroxyphenyl)-2H-1-benzopyran-7-ol; 4',7 25 mgDihydroxyisoflavane 100 mgC15H14O3 FW 242.27 [94105-90-5]Is an isoflavinoid metabolized from diadzein by bacterial flura in the intestines.

Equol may have beneficial effects on the incidence of prostatic cancer. It functions

as a DHT blocker and preferentially activates estrogen receptor type B.Moors S. Molecular nutrition & food research (2007), 51(7), 787-98.

Tonetti D. A. Nutrition and cancer (2007), 58(2), 222-9.

Jackman K. A. Current medicinal chemistry (2007), 14(26), 2824-30

E6814 Erdosteine 100 mgC8H11NO4S2 FW 249.31 [84611-23-4] 500 mgA homocysteine-derived expectorant. It undergoes metabolic conversion to 1 g produce a thiol containing compound that has mucolytic and free radical scavenging activity.

Dechant KL, Noble S. Drugs 52:875-81 (1996).

Hosoe H, Kaise T, Ohmori K. J Pharm Pharmacol 51:959-66 (1999).

E6825 Ergosterol 5 gC28H44O FW 396.65 [57-87-4] 10 gA membrane lipid found almost exclusively in fungi. It is used as an indicator 25 gof living fungal biomass. 100 gMille-lindblom C, von Wachenfeldt E, Tranvik LJ. J Microbiol Methods. 59:253-62 (2004).

Kasparovsky T, Blein JP, Mikes V. Plant Physiol Biochem. 42:429-35 (2004).

E6846 Erlotinib Monohydrochloride (See page 24 for more info) 10 mgC22H23N3O4

.HCl FW 429.9 25 mgThe hydrochloride salt of a quinazoline derivative with anti-neoplastic 100 mg properties. Competes with ATP, Erlotinib reversibly binds to EGFR tyroside kinase

which blocks the signal transduction events and tumorigenic events associated with EGFR activation.Ali, S. Molecular Cancer Therapeutics (2008), 7(6), 1708-1719.

Rudin, C. M. Journal of Clinical Oncology (2008), 26(7), 1119-1127.

Burris, H. Oncologist (2008), 13(3), 289-298.

E6880 Erucin 25 mgC6H11NS2 FW 161.29 [4430-36-8] 50 mg

100 mg

S

O

HN

S COOH

O

O

O

O

O O

O

O

O

H3C

H

H

H

CH3

CH3

R

H

OCH3

H3C

H

OCH3

H3C

H

OH

H

CH3

O

OH

CH3

HNH3C

O

Map-Har-Gly-Asp-Trp-Pro-Cys-

NH2

(Disulfide bridge, Map1-Cys6)

N

N

HNCH

O

O

OH3C

OH3C

HCl

HO O

OH

OCl

NF

N

N

S N C S

P(O2Ca)O

O


E6896 Erysolin 25 mgC6H13NO2S2 FW 193.29 [504-84-7] 50 mg

100 mg500 mg

E6994 Erythromycin 5 gC37H67NO13 FW 733.93 [114-07-8] 25 gErythromycin is a macrolide antibiotic, found to exert anti-inflammatory effect. 100 gIt inhibits NF-kappaB DNA binding activities, IL-8 NF-kappaB transcription,

and CYP3A4/5.Aoki Y, Kao PN. Antimicrob Agents Chemother. 43:2678-84 (1999).

Tran JQ, Di Cicco RA, Sheth SB et al. J Clin Pharmacol. 39:513-9 (1999).

E6995 Erythromycin Ethylsuccinate 5 gC43H75NO16 FW 862.05 [41342-53-4] 25 g

100 g

E6996 Erythromycin Thiocyanate 25 gC37H67NO13HSCN FW 793.0 [7704-67-8] 100 gAn antimicrobial agent.

Vanhaecke E, De Backer P, Remon JP, Devriese LA. J Vet Pharmacol Ther. 13:356-60 (1990).

E6993 Erythromycin resistance peptide MRLFV 1 mgC31H52N8O6S FW 664.86 2 mg

5 mg

E6997 Erythropoietin 50 U [11096-26-7]Human, Recombinant, Ultra Pure

Key regulator of erythroid blood cell proliferation and differentiation. It induces p21ras

activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells.

Torti M, Marti KB, Altschuler D et al. J Biol Chem. 267:8293-8 (1992).

Wuelle FW, Wojchowski DM. J biol Chem. 266:609-14 (1991).

E7309 Esculetin 500 mgC9H6O4 FW 178.14 [305-01-1] 1 gA lipoxygenase inhibitor. Potent chemopreventive agent capable of reducing oxidative

stress in liver, inhibiting carcinogen DNA binding in human bronchial epithelial cells

and inducing reduced glutathione in buffalo and rat liver cells.

Matsunaga K, Yoshimi N, Yamada Y et al. Jpn J Cancer Res. 89:496-501 (1998).

Lin WL, Wang CJ, Tsai YY et al. Arch Toxicol.74:467-72 (2000).

Sharma S, Stutzman JD, Kelloff GJ, Steele VE. Cancer Res. 54:5848-55 (1994).

E7310 Esculin 5 gC15H16O9 FW 340.28 [531-75-9] 10 gA naturally occuring antioxidant. It inhibits chemically induced carcinogenesis in

the mouse skin and kidney.Van Duren BL, Goldschmidt BM. J Natl Cancer Inst. 56:1237-42 (1976).

Imaida K, Hirose M, Yamaguchi S et al. Cancer Lett. 55:53-9 (1990).

E7357 Esomeprazole potassium (See page 27 for more info) 25 mgC17H19N3O3S FW 345.42 100 mgA proton pump inhibitor. Used as an antiulcerative agent. 500 mgGarnett WR. Ann Pharmacother. 30:1425-36 (1996).

O OHO

HO

Met-Arg-Leu-Phe-Val

S N C S

O

O

P(O2Ca)O

O


E7376 Estradiol 1 gC18H24O2 FW 272.38 [50-28-2] 5 gPotent mammalian estrogenic hormone useful in the prevention of neuro- 25 gdegenerative diseases such as Alzheimer's and Parkinson disease, in both men

and women. Found to be major steroid mitogen in premenopausal women.

Bhavnani BR. J Steroid Biochem Mol Biol. 85:473-82 (2003).

E7578 Estramustine 100 mgC23H31Cl2NO3 FW 440.40 [2998-57-4] 250 mgA chemotherapy agent used to treat prostate cancer. It is a derivative of estrogen 1 gwith an nitrogen mustard-carbamate ester moiety that makes it a alkylating antineoplastic

agent similar to mechlorethamine, with estrogen-induced specificity.

Petrylak DP, Tangen CM, Hussain MH, et al. N. Engl. J. Med. 351:1513-1520 (2004).

E7579 Estramustine phosphate sodium 100 mgC23H32Cl2NO6PNa2 FW 566.36 [52205-73-9] 250 mgA unique antitumour agent, is selectively taken up by prostate cells and exerts 1 gantineoplastic effects by interfering with microtubule of dynamics and by reducing

plasma levels of testosterone.

Perry CM, McTavish D. Drugs Aging. 1995 Jul;7(1):49-74.

E7377 Estriol 100 mgC18H24O3 FW 288.38 [50-27-1] 500 mgEstradiol metabolite was found to prevent bone loss in osteoporotic rats and 1 g post menopausal women. Provides protection against mammary carcinogenisis

and urogenital tract aging.

Rajkumar L, Guzman RC, Yang J et al. Breast Cancer Res. 6:R31-7 (2004).

Luo XH, Liao EY. Endocr Res. 29:343-51 (2003).

Dessole S et al. Menopause. 11:49-56 (2004).

E7378 Estrone 1 gC18H22O2 FW 270.37 [53-16-7] 5 gEstradiol metabolite found to reduce colon tumorigenesis in mice, 25 g independently of ERalpha. Found to inhibit BCRP-mediated drug efflux and

overcome drug resistance.

Guo JY et al. J Nutr. 134:179-82 (2004).

Imai Y, Tsukahara S, Ishikawa E et al. Jpn J Cancer Res. 93:231-5 (2002).

E7228 Ethacridine Lactate Monohydrate 25 gAcrinol; ethodin; 6,9-Diamino-2-ethoxyacridine-DL-lactate monohydrate 50 gC15H15N3O.C3H6O3

.H2O FW 361.39 [6402-23-9] 100 gAn antiseptic agent found to be an effective abortifacient.

Bygdeman M. Clin Obstet Gynaecol. 11:573-84 (1984).

Gupta S, Sachdeva L, Gupta R. Indian J Matern Child Health. 4:59-61 (1993).

E7230 Ethambutol 25 gC10H24N2O2 FW 277.24 [1070-11-7] 100 gAn antibacterial agent.

Bernard EM, Edwards FF, Kiehn TE et al. Antimicrob Agents Chemother. 37:2323-6 (1993).

E7324 Ethisterone 1 gC21H28O2 FW 312.45 [434-03-7] 5 gA progestogen that counteracts the estrogenic proliferative effect on the 25 gendometrium. 100 gFerrero S, Gerbaldo D, Fulcheri E, Cristoforoni P. Minerva Ginecol. 54:519-30 (2002).

H3CNH

HN

CH3

OH

OH

OH

O

O

N

Cl

Cl

OH

O

O

N

Cl

Cl

NaHPO4

P(O2Ca)O

O


E7329 Ethoxyquin 100 gC14H19NO FW 217.31 [91-53-2] 250 gA synthetic antioxidant that inhibits chemically induced carcinogenesis. It 1 kg exerts its chemopreventive action by inducing glutathione synthetase, one of

the enzymes in the synthesis of glutathione, and the phase II drug metabolizing enzyme,

glutathione S-transferase (GST).

Shpherd AG, Manson MM, Ball Hw, Mclellan LI. Carcinogenesis. 21:1827-34 (2001).

Hayes JD, Mc Leod R, Ellis EM et al. IARC Sci Publ. 139:175-87 (1996).

E7731 17-alpha-Ethynylestradiol 1 gC20H24O2 FW 296.40 [57-63-6] 5 gA synthetic estrogen is the active component in oral contraceptive pills. 10 gScholz S, Gutzeit HO. Aquat. Toxicol. 50:363-373 (2000).

E7433 Etidronate Disodium 1 gC2H6Na2O7P2 FW 249.99 [7414-83-7] 5 gA bisphosphonate bone resorption inhibitor.

E7556 Etodolac (See page 17 for more information) 100 mgC17H21NO3 FW 287.35 [41340-25-4] 250 mgA COX-2 inhibitor with anti-inflammatory and analgesic activity. It has been 1 g shown to inhibit growth and PCNA expression and induce cell cycle arrest in human

hepatocellular carcinoma cell lines, in addition to suppressing the occurrence of aberrant

crypt foci and tumors in colitis-induced tumorigenesis in rats.

Cheng J, Imanishi H, Liu W et al. Cancer Sci. 95:666-73 (2004).

Takeda J, Kitajima K, Fujii S et al. Oncol Rep. 11:981-5 (2004).

Lynch S, Brogden RN. Drugs. 31:288-300 (1986).

E7657 Etoposide (See page 15 for more information) 100 mgC29H32O13 FW 588.56 m.p. 236-2510C [33419-42-0] 500 mgAn anticancer agent, topoisomerase inhibitor, and apoptosis inducer.

Fearnhead JO. Biochem.Pharmacol. 48:1073-1079 (1994).

deJong RS, Chwalinski ., Snowden RT et al. Anticancer Res. 15:2319 (1995).

E7658 Etoposide Phosphate 25 mgC29H33O16P FW 668.54 [117091-64-2] 100 mgInhibitor of the enzyme topoisomerase III. Etoposide forms a ternary complex with 250 mgDNA and the topoisomerase II enzyme, preventing re-ligation of the DNA strands.

This causes errors in DNA synthesis and promotes apoptosis of the cancer cell.

Gordaliza M, Garcia PA, del Corral JM, et al. Toxicon. 44(4):441-459 (2004).

E7668 Etretinate 25 mgC23H30O3 FW 354.49 [54350-48-0] 100 mgAn aromatic retinoid used in treatment of severe psoriasis, lichen 500 mg amyloidosus and keratotic genodermatosis.

Helander I. Hopsu-Havu VK. Clin Exp Dermatol. 11: 574-77 (1986).

Brazzell, RK, Colburn, WA. J Am Acad Dermatol. 6: 643–651 (1982).

E8419 Everolimus 1 mgC56H83NO14 FW 958.22 [159351-69-6] 5 mgAn immunosuppressant to prevent rejection of organ transplants. 25 mgEisen HJ, Tuzcu EM, Dorent R, et al. N. Engl. J. Med. 349:847-858 (2003).

HN

CH3CH2O

CH3

CH3

CH3

HN

O

H3C

COOH

CH3

COOC2H5H3C

CH3OCH3

CH3 CH3 CH3

O

O

O

H3CO OCH3

OPO3H2

OO

O

O

OH

OH

O

P(O2Ca)O

O


E8657 Evodiamine 100 mgC19H17N3O FW 303.36 [518-17-2] 250 mgA non-pungent vanilloid receptor agonist isolated from Evodia rutaecarpa that 1 g induces apoptosis in leukemic U937 cells.

Kobayashi Y, Nakano Y, Kizaki M et al. Planta Med. 67:628-633 (2001).

Lee TJ, Kim EJ, Kim S et al. Mol Cancer Ther. 5:2398-2407 (2006).

E9317 Exemestane 25 mgC20H24O2 FW 296.40 [107868-30-4] 100 mgA steroidal aromatase inhibitor.

Giudici, D. J. Steroid Biochem 30:391-394 (1988).

E9416 Exendin-3 0.5 mgC184H282N50O61S FW 4202.66 [130391-54-7] 1 mg

2.5 mg

E9417 Exendin-4 0.5 mgC184H282N50O60S FW 4186.03 [141758-74-9] 1 mg

2.5 mg

E9418 Exendin (9-39) 0.5 mgC149H234N40O47S FW 3369.83 [133514-43-9] 1 mg

2.5 mg

E9819 Ezetimibe 25 mgC24H21F2NO3 FW 409.43 [163222-33-1] 100 mgIs an anti-hyperlipidemic medication used to lower cholesterol levels. It acts by 250 mginhibing the absorptioin of cholesterol from the diet. Specifically it bings to a

critical mediator of cholesterol absorption (NPC1L1). Brown, B. New England Journal of Medicine (2008), 359(5), 532-533.

Maki-Petaja, K. Journal of the American College of Cardiology (2007), 50(9), 852-858.

F0010 FAM FLICATM Poly Caspases Assay Kit 25 TestsFAM-VAD-FMK 100 TestsMeasures apoptosis via caspase activity in whole cells.

F0011 FAM FLICATM Caspase 1 Assay Kit 25 TestsFAM-YVAD-FMK 100 TestsDetects Caspase 1 activity.

F0012 FAM FLICATM Caspase 2 Assay Kit 25 TestsFAM-YDVAD-FMK 100 TestsDetects Caspase 2 activity.

F0014 FAM FLICATM Caspase 6 Assay Kit 25 TestsFAM-VEID-FMK 100 TestsDetects Caspase 6 activity.

F0015 FAM FLICATM Caspase 8 Assay Kit 25 TestsFAM-LETD-FMK 100 TestsDetects Caspase 8 activity.

O

CH2

O

H H

CH3 H

CH3

H-His-Ser-Asp-Gly-Thr-Phe-

Thr-Ser-Asp-Leu-Ser-Lys-Gln-

Met-Glu-Glu-Glu-Ala-Val-Arg-

Leu-Phe-Ile-Glu-Trp-Leu-Lys-

Asn-Gly-Gly-Pro-Ser-Ser-Gly-

Ala-Pro-Pro-Pro-Ser-NH2

H-His-Gly-Glu-Gly-Thr-Phe-

Thr-Ser-Asp-Leu-Ser-Lys-Gln-

Met-Glu-Glu-Glu-Ala-Val-Arg-

Leu-Phe-Ile-Glu-Trp-Leu-Lys-

Asn-Gly-Gly-Pro-Ser-Ser-Gly-

Ala-Pro-Pro-Pro-Ser-NH2

H-Asp-Leu-Ser-Lys-Gln-Met-

Glu-Glu-Glu-Ala-Val-Arg-Leu-

Phe-Ile-Glu-Trp-Leu-Lys-Asn-

Gly-Gly-Pro-Ser-Ser-Gly-Ala-

Pro-Pro-Pro-Ser-NH2

F

OH

N

O

HO

F

P(O2Ca)O

O


F0016 FAM FLICATM Caspase 9 Assay Kit 25 TestsFAM-LEHD-FMK 100 TestsDetects Caspase 9 activity.

F0017 FAM FLICATM Caspase 10 Assay Kit 25 TestsFAM-AEVD-FMK 100 TestsDetects Caspase 10 activity.

F0018 FAM FLICATM Caspase 13 Assay Kit 25 TestsFAM-LEED-FMK 100 TestsDetects Caspase 13 activity.

F0019 FAM-Phe-CMK FLISPTM Assay Kit 25 TestsFFCK 100 TestsThe FFCK kit detects chymotrypsin-like serine proteases that favor phenylalanine.

F0020 FAM-Lys-CMK FLISPTM Assay Kit 25 TestsFKCK 100 TestsQuantitate serine protease activity in whole living cells without using antibodies.

F0021 FAM-Leu-CMK FLISPTM Assay Kit 25 TestsFLCK 100 TestsThe FLCK kit is for those that favor leucine; use the kits with an additional spacer sequence

to reduce steric hindrance at the binding site of the serine protease.

F0022 FAM-Spacer-Phe-CMK FLISPTM Assay Kit 25 TestsFSFCK 100 TestsQuantitate serine protease activity in whole living cells without using antibodies.

F0023 FAM-Spacer-Leu-CMK FLISPTM Assay Kit 25 TestsFSLCK 100 TestsQuantitate serine protease activity in whole living cells without using antibodies.

F0024 FAM-Leu-DAP FLISPTM Assay Kit 25 TestsFLDAP 100 TestsQuantitate serine protease activity in whole living cells without using antibodies.

F0048 Famciclovir 50 mgC14H19N5O4 FW 321.33 [104227-87-4] 100 mgAntiviral agent that is an ester of penciclovir for improved absorption. 500 mgEnright AM, Prober C. Herpes. 10:32-7 (2003).

Lilie HM, Wassilew S. Drugs Aging. 20:561-70 (2003).

F0150 Famotidine 500 mgC8H15N7O2S3 FW 337.45 [76824-35-6] 1 gAn antiulcerative agent that has an immunomodulating effect. Effective in 5 g the prevention and control of chemotherapy-induced gastric mucosal injury.Hahm KB, Kim WH, Lee SI et al. Scand J Gastroenterol. 30:265-71 (1995).

Mori K, Tominaga K, Yokoyama K et al. J Cancer Res Clin Oncol. 121:367-70 (1995).

F0268 Farnesol 50 mlC15H26O FW 222.37 [4602-84-0] 100 mlPolyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.

Haug JS, Goldner CM, Yazlovitskaya EM et al. Biochim Biophys Acta. 1223:133-40 (1994).

Yaguchi M, Miyazawa K, Katagiri T et al. Leukemia. 11:779-87 (1997).

H3C OH

CH3 CH3 CH3

S

N

N

H2N

S

N

S NH2

NH2

H2NO

O

P(O2Ca)O

O


F0275 Fasudil Hydrochloride (See page 31 for more info) 100 mgC14H17N3O2S.HCl FW 327.83 [105628-07-7] 250 mgA potent Rho-kinase inhibitor and vasodilator. It has been found to be effective for 1 gthe treatment of pulmonary hypertension.

Shibuya M, Suzuki Y (September 1993). No to Shinkei 45 (9): 819–24.

Doggrell SA (2005). Expert Opin Investig Drugs 14 (9): 1157–1159.

F1607 Febuxostat 250 mgC16H16N2O3S FW 316.37 [144060-53-7] 1 gFebuxostat is a non-purine selective inhibitor of xanthine oxidase. It works by

non-competitively blocking the channel leading to the active site on xanthine oxidase.

Stamp LK, O’Donnell JL, Chapman PT. J. Intern. Med. 37:258-266 (2007).

F1745 Felodipine 50 mgC18H19Cl2NO4 FW 384.25 [72509-76-3] 100 mgFelodipine is effective at preventing angina pectoris. 250 mgDetry JM, De Coster PM, Renkin J. Am J Cardiol. 52:453-457 (1983).

F1650 Fenbendazole 5 gC15H13N3O2S FW 299.35 [43210-67-9] 10 gA highly effective anthelmintic used to control trematodes and cestodes. 100 gIt is a potent CYP1A2 inducer.

Baeder C, Bahr H, Christ O et al. Experientia. 30:753-754 (1974).

F1652 Fenbufen 1 gC16H14O3 FW 254.28 [36330-85-5] 5 gAn anti-inflammatory analgesic. 10 gChild RG, Osterberg AC, Slobida AE et al. J. Pharm Sci 66:466-476 (1977).

F1853 Fenofibrate 5 gC20H21ClO4 FW 360.83 [49562-28-9] 25 gA hypolipidemic drug useful in prevention of myocardial inflammation and 100 g fibrosis. PPARalpha activator that is a potent and well tolerated lipid lowering drug.Diep QN, Benkirane K, Amiri F et al. J Mol Cell Cardiol. 36:295-304 (2004).

Roberts WC. Cardiology. 76:169-79 (1989).

F1654 Fenoldopam mesylate 25 mgC16H16ClNO3 CH4O3S FW 401.87 [67227-57-0] 100 mgA renal vasodilator that stimulates renal vascular dopamine receptors with 500 mg little effect on the central dopamine receptors.

Hahn RA, Wardell JR Jr, Sarau HM, Ridley PT. J. Pharm & Expt Ther. 223:305-313 (1982).

F1655 Fenoprofen calcium dihydrate 1 g2C33H24O6

.Ca .2H2O FW 558.64 [53746-45-5] 5 gA NSAID inhibits prostaglandin synthesis and adherence of 10 g polymorphonuclease leukocytes. It has antiproliferative effects on human colon cancer cells.

Venezio FR, DiVincenzo C, Pearlman F, Phair JP. J Infec Diseases. 152:690-694 (1985).

Patrono C, Ciabattoni G, Grossi-Belloni D. Pharmacol Res Comm. 6:509-518 (1974).

Hixson LJ, Alberts DS, Krutzsch M et al. Cancer Epid Biomark Prev. 3:433-438 (1994).

Fenretinide (See N-(4-Hydroxyphenyl)retinamide)

F1854 Fenticonazole Nitrate 100 mg C24H21Cl2N2OS .HNO3 FW 518.41 [73151-29-8] 250 mgAn azole antifungal drug 1 gAthow-Frost T A, Current medical research and opinion (1986), 10(2), 107-16

O

O CH3

CH3O

O

H3C CH3

Cl

N

SN

HN

O

O

HCl

O

O

O

H2O

2

Ca2+

O

C

H3C

H3C

N

S

NCH3

OH

O

P(O2Ca)O

O


F1669 Ferulic acid (See page 10 for more information) 5 gC10H10O4 FW 194.18 m.p. 168-1710C [1135-24-6] 25 gA chemopreventive analogue of caffeic acid.

Tanaka T, Kojima T, Kawamori T et al. Carcinogenesis 14:1321-1325 (1993).

F1670 Ferulic acid methyl ester 1 gC11H12O4 FW 208.21 [2309-07-1] 5 gMethyl ester analogue of Ferulic acid 25 g

F1895 Fexofenadine Hydrochloride 25 mgC32H40ClNO4 FW 538.12 [153439-40-8] 100 mgA non-sedating H1 receptor antagonist that may be useful to treat daily 500 mgsymptoms of eczematous diseases.Bronsky EA, Falliers CJ, Kaiser HB et al. Allergy Asthma Proc. 19:135-141 (1998).

Katagiri K, Arakawa S, Hatano Y, Fujiwara S. J Dermatol. 33:75-79 (2006).

F3204 Fibrinogen-binding Peptide 5 mgC25H39N7O8 FW 565.63

F3205 Fibrinogen gamma-chain dodecapeptide 1 mgC50H80N18O16 FW 1189.29 2 mgHelps to inhibit the agonist-innduced aggregation of platelets and fibrinogen binding 5 mgglycoprotein.

F3206 Fibrinolysis Inhibiting Factor 1 mgC18H31N7O5 FW 425.49 2 mgInhibits the break down of fibrin clots after coagulation. 5 mg

F3208 Fibrinopeptide B, human 1 mgC66H93N19O25 FW 1552.59 [36204-23-6] 2 mg

5 mg

F3209 Fibronectin-Binding Protein 0.5 mgC190H283N49O66 FW 4309.66 [119977-20-7] 1 mgInhibits binding of fibronectin to bacterial cells. 2.5 mg

F3207 Fibronectin CS-1 Peptide 1 mgC38H64N8O15 FW 872.97 2 mgThis peptide is a cell attachment domain that is located in fibronectin. 5 mg

F3354 Finasteride 100 mgC23H36N2O2 FW 372.54 [98319-26-7] 500 mgFinasteride is a synthetic 4-azasteroid. It is a specific inhibitor of the enzyme steroid

5-a-reductase which is responsible for the conversion of testosterone into the potent

androgen 5a-dihydrotestosterone.

Peters DH, Sorkin EM. Drugs 46:177-208 (1993).

Gormley GJ. Biomed Pharmacother 49:319-24 (1995).

F3454 Fingolimod Hydrochloride 10 mgC19H33NO2

.HCl FW 343.93 [162359-56-0] 25 mgTraps lymphocytes in lymph nodes, preventing them from moving to the central 100 mgnervous system for auto-immune responses in multiple sclerosis.

Alejandro Horga; Xavier Montalban 06/04/2008; Expert Rev Neurother. 2008;8(5):699-714

CH3O

HO

OH

O

Glu-His-Ile-Pro-Ala

His-His-Leu-Gly-Gly-Ala-Lys-

Gln-Ala-Gly-Asp-Val

Gly-Pro-Arg-Pro

pGlu-Gly-Val-Asn-Asp-Asn-Glu-

Glu-Gly-Phe-Phe-Ser-Ala-Arg-

OH

H-Phe-Asn-Lys-His-Thr-Glu-

Ile-Ile-Glu-Glu-Asp-Thr-Asn-

Lys-Asp-Lys-Pro-Ser-Tyr-Gln-

Phe-Gly-Gly-His-Asn-Ser-Val-

Asp-Phe-Glu-Glu-Asp-Thr-

Leu-Pro-Lys-Val-OH

Glu-Ile-Leu-Asp-Val-Pro-Ser-

Thr

N

OH

HO

O

OHH3C CH3

HCl

NH2

OH

OHHCl

P(O2Ca)O

O


F3473 Fisetin 100 mgC15H10O6 FW 286.24 [528-48-3] 500 mgIt is a coloring agent; Fisetin is a potent sirtuin activating compound (STAC)

David A. Sinclair et al. Discover Three Classes of Molecules that Activate Sirtuins (Including Resveratrol)

FK506 (See Tacrolimus)

F4400 Flag Peptide 0.5 mgC41H60N10O20 FW 1012.99 [98849-88-8] 1 mg

2.5 mg

F4501 Flavanone 10 gC15H12O2 FW 224.25 [487-26-3] 25 gNatural flavonoid from plants. Found to inhibit tumor cells in culture. Its oxime

derivative induces apoptosis.

Kuntz S, Wenzel U, Daniel H. Eur J Nutr. 38:133-42 (1999).

F4502 Flavokawain A 5 mgC18H18O5 FW 314.33 [64680-84-8] 10 mgA minor component of kava extract.

F4503 Flavokawain B 5 mgC17H16O4 FW 284.31 [1775-97-9] 10 mgA minor component of kava extract.

F4518 Fleroxacin 5 gC17H18F3N3O3 FW 369.34 [79660-72-3] 10 gAn antibacterial agent with antiproliferative effects. 25 gEbisuno S, Nishikawa T, Kohjimoto Y et al. Urol Int. 62:150-4 (1999).

F4420 Boc-F-L-F-L-F 5 mgC44H59N5O8 FW 785.99 [148182-34-7] 10 mgA fluorescent N-Formyl-peptide receptor antagonist. 25 mgJohansson B, Wymann MP, Holmgren-Peterson K, Magnusson KE. J Cell Biol. 121:1281-1289 (1993).

F4556 Florfenicol 1 gC12H14Cl2FNO4S FW 358.21 [73231-34-2] 5 gA potent broad spectrum antimicrobial agent. 10 gPriebe S, Schwarz S. Antimicrob Agents Chemother. 47:2703-5 (2003).

F4557 Floxuridine 500 mgC9H11FN2O5 FW 246.19 [50-91-9] 1 gAntitumor agent used in chemotherapy of colon cancer.

Bilchik AJ, Wood TF, Chawla SP, Rose DM et al. Clin Colorectal Cancer 1:36-42 (2001).

F4679 Flubendazole 10 gC16H12FN3O3 FW 313.28 [31430-15-6] 25 gA potent broad spectrum anthelmintic. 100 gWilliam S, Guirguis F, Nessim NG. Arzneimittelforschung. 53:532-7 (2003).

F4682 Fluconazole (See page 16 for more information) 500 mgC13H12F2N6O FW 306.27 [86386-73-4] 1 gA triazole broad-spectrum antifungal agent. Effective against Candida spp., 5 g cryptococcus neoformans and dermatophytes.Vincent-Ballereau FN, Patey ON, Lafaix C. Pharm Weekbl Sci. 13:45-57 (1991).

Martin MV. J Antimicrob Chemother. 44:429-37 (1999).

O

HO OCH3

OCH3

O

OCH3HO OCH3

OCH3

N

N

H3C

N

O

COOH

F

F

F

N

HN

O

NH

O

OCH3

F

Boc-Phe-Leu-Phe-Leu-Phe-OH

H-Asp-Tyr-Lys-Asp-Asp-Asp-

Asp-Lys-OH

O

O

O

OH

O

HO

OH

OH

N

OH

N N

N

F

F

N

N

P(O2Ca)O

O


F4781 Fludarabine 5 mg2-Fluoroadenine-9-b-D-arabinofuranoside 10 mgC10H12FN5O4 FW 285.23 [21679-14-1] 25 mgAn adenosine analogue that resists deamination. This analogue shows effective

antileukemic activity.Casper ES, Mittelman A, Kelson D, Young CW. Cancer Chemother Pharmacol. 15:233-235 (1985).

Warrell RP Jr, Berman E. J Clin Oncol. 4:74-79 (1986).

F4782 Fludarabine Phosphate 5 mgC10H13FN5O7P FW 365.21 [75607-67-9] 10 mgHighly effective in the treatment of chronic lymphocytic leukemia, producing 25 mg higher response rates than alkylating agents. It is a purine analog which inhibits

DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase.

Cazin, B. British Journal of Haematology (2008), 143(1), 54-59.

F4483 Flufenamic acid (See page 17 for more information) 10 gC14H10F3NO2 FW 281.23 [530-78-9] 50 gA NSAID found to be a reversible gap junction blocker.

Harks, EG., de Roos, AD., Peters, PH., et al. J. Pharm. Exptal Ther. 298:1033-1041 (2001).

F4580 FluM1 A2 (58-66) 1 mgC49H75N9O11 FW 966.2 [141368-69-6] 2 mg

5 mg

F4681 Flumazenil 25 mgC15H14FN3O3 FW 303.29 [78755-81-4] 100 mgA benzodiazepine antagonist.Jung HY, Sohn YH, Mason A et al. Clin Neurophysiol.115:325-9 (2004).

F4881 Flumequine Sodium 1 gC14H11FNNaO3 FW 283.23 5 gA synthetic fluoroquinolone antibiotic. It interferes with enzymes that unwind DNA 25 gduring the duplication process. Recent interest has been directed to the platinum (II)

complex of flumequine as potential antitumor agents.

Zweerink MM, Edison A. Antimicrob Agents Chemother. 29:598-601 (1986).

Kim YS, KIM KM, Song R. et al J. inorg. Biochem 87:157-163 (2001).

F4582 Fluocinolone Acetonide 25 mgC24H30F2O6 FW 452.49 [67-73-2] 100 mgA synthetic glucocorticoid with anti-inflammatory and anti-carcinogenesis 250 mg properties. It inhibits tumor promotion in mouse skin when applied with a 1 g promoting agent at the early stages of promotion. It was also found to inhibit induction

of early growth response-1 (Egr-1) gene in SENECAR mice and phospholipid peroxidation in CD1

mice which were exposed to 12-O-tetradecanoyl phorbol-13-acetate (TPA) treatment.

Digiovanni J, kruszewski FH, Chenicek KJ. Carcinogenesis. 9:1445-50 (1988).

Riggs PK, Rho O, Digiovanni J. Mol Carcinog. 27:247-51 (2000).

Beckman JK, Bagheri F, Ji C, Blair IA, Marnett LJ. Carcinogenesis. 15:2937-44 (1994).

F4480 5-Fluorouracil 1 gC4H3FN2O2 FW 130.08 m.p. 280-2820C [51-21-8] 5 gA pyrimidine antimetabolite. Prevents the biosynthesis of thymidine 25 gduring DNA synthesis.Ananthan S, In "Cancer Chemotherapeutic Agents" Foye WO, Ed., ACS Professional Ref. pp.49-54, (1995).

F4780 Fluoxetine hydrochloride (See page 20 for more info) 1 gC17H18F3NO.HCl FW 345.79 [59333-67-4] 5 gA specific serotonin uptake inhibitor. It was found to exert inhibitory or stimulating effects

on T-lymphocyte proliferation depending on the concentration.

Wong DT et al. Life Sci. 15:471 (1974).

Edgar VA, Genaro AM, Cremaschi G, Sterin-Borda L. Cell Signalling 10:721-726 (1998).

Gly-Ile-Leu-Gly-Phe-Val-Phe-

Thr-Leu

N

NN

N

NH2

F

OOH

OH

O

P OHO

HO

P(O2Ca)O

O


F4584 Fluphenazine HCl 1 gC22H26F3N3OS .2HCl FW 510.44 [146-56-5] 5 gA neuroleptic drug that is a dopamine receptor antagonist. Aacts as an 25 g antimutagen, which may be explained by its ability to reduce the level of free radicals.

Gasiorowski K, Brokos B, Szyba K et al. Mutagenesis. 16:31-8 (2001).

Nasello AG, Gidali D, Felicio LF. Pharmacol Biochem Behav. 75:895-901 (2003).

F4583 Flupirtine Maleate (See page 18 for more information) 10 mgC15H17FN4O2 FW 304.32 [75507-68-5] 25 mgCurrently under a clinical trial (recruiting phase) as a treatment for Multiple 100 mg Sclerosis and has been used as an analgesic.

Rupalla, Katrin, European Journal of Pharmacology (1995), 294(2/3), 469-73.

F4481 Flurbiprofen (See page 25 for more information) 1 gC15H13FO2 FW 244.26 m.p. 114-1170C [5104-49-4] 5 gA non-steroidal anti-inflammatory agent with potential for colon 25 gcancer chemoprevention.Wechter WJ, Kantoci D, Murray ED, et al. Cancer Res.,57:4316-4324 (1997)

F4680 Flutamide (See page 3 for more information) 1 gC11H11F3N2O3 FW 276.22 [13311-84-7] 5 gAn anti-androgen with chemopreventive properties against bladder and prostate carcinogenesis.

It inhibits the expression of transforming growth factor beta-1 (TGF-beta1) which is regulated

by testosterone. It is also used to treat prostate cancer.

Imad S, Akaza H, Ami y, Koiso K, Ideyama Y, Takenaka T. Eur Urol. 31:360-4 (1997).

Xie B, Tsao SW, Wong YC, Breast Cancer Res Treat. 58:227-39 (1999).

Fossa SD, Slee PH, Brausi M et al. J Clin Oncol. 19 :62-71 (2001).

F4683 Fluticasone Propionate 10 mgC25H31F3O5S FW 500.57 [80474-14-2] 25 mgFluticasone is a synthetic steroid of the glucocorticoid family of drugs, that is 100 mgused for treating allergic conditions of the nose. Fluticasone mimics the naturally

occurring hormone produced by the adrenal glands; cortisone and hypercortisone.

Baldwin, C. M. Drugs (2008), 68(12), 1723-1739.

Meltzer, E. O. Clinical Therapeutics (2008), 30(2), 271-279.

F4883 Flutriafol 500 mgC16H13F2N3O FW 301.29 [76674-21-0] 5 gA triazole fungicide, bactericide, and wood preservative 25 gGatarayiha MC, Laing MD, Miller RM. Pest Manag. Sci. 66:773-778 (2010).

F4482 Fluvastatin sodium (See page 26 for more information) 10 mgC24H25FNNaO4 FW 433.45 [93957-55-2] 50 mgAn anticholesterol agent.It is a HMG-CoA reductase inhibitor and antioxidant. 100 mgSumi D, Hayashi T,Thakur NK. Atherosclerosis. 155:347-57 (2001).

Yamamoto A, Ichihara K, Hoshi K. J Pharm Pharmacol. 53:227-32 (2001).

Obata T, Ebihara A, Yamanaka Y. Biochim Biophys Acta. 1536:55-63 (2001).

F4783 Fluvoxamine Maleate 25 mgC15H21O2N2F3

.C4H4O4 FW 434.41 [61718-82-9] 100 mgIt is a potent and selective serotonin reuptake inhibitor. 500 mgHashimoto K et al., Narita N (1996). Eur J Pharmacol 307: 117–9.

F4856 Fmoc-Lys(Boc)-Leu-Lys(Boc) 1 gC26H35N8O7S Mol Wt: 809.9

F4859 F-M-R-F 5 mgC29H41N7O5S FW 599.76 10 mg

25 mg

CF3

NO2(CH3)2CHCONH

Fmoc-Lys(Boc)-Leu-Lys(Boc)

H-Phe-Met-Arg-Phe-OH

O

F

F

HO

H

OS

F

CO2Et

NO

H2N

O

F

F

F

OHHO

OO

F

CHCO2H

CH3

N NH2

NH

O O

NH

F

HO2C CO2H

P(O2Ca)O

O


F4857 FMRF amide 1 mgC29H42N8O4S FW 598.76A molluscan cardioexcitatory neuropeptide that localizes with neuropeptide Y in the brain. It inhibits the exchange of sodium and calcium.

F4858 FMRF-like peptide from Snail 1 mgC44H62N11O10 FW 904.03

F5745 Folic Acid 10 gC19H19N7O6 FW 441.40 [59-30-3] 50 gFolate is an important cofactor in the transfer of one-carbon moieties and plays a major

role in the formation of S-adenosyl methionine, the universal methyl donor, as well as in

the synthesis and repair of DNA and RNA. Studies show that folate supplementation supressess colorectal carcinogenesis and reduces the risk of pancreatic and breast cancer.Choi SW, Mason JB. J Nutr. 130:129-32 (2000).

Song J, Sohn KJ, Medline A, Ash C, Gallinger S, Kim YI. Cancer Res. 60:3191-9 (2000).

Kim YI. Nutr. Rev. 57:314-21 (1999).

F5846 Folinic Acid Calcium Salt (See Calcium Folinate, Pentahydrate)

F5766 Forchlorfenuron (KT-30) 500 mgC12H10ClN3O FW 247.68 [68157-60-8] 1 gIt is a cytokinin that promotes cell division and cell differentiation. It is used 5 gas a plant growth regulator that improves fruit size and yield.

Shudo K. Yakugaku Zasshi. 114:577-88 (1994).

Li C, Bangerth F. J Plant Physiol. 160:1059-63 (2003).

F5769 Formestane 100 mgC19H26O3 FW 302.41 [566-48-3] 500 mgA steroidal aromatase inhibitor used in the treatment of postmenopausal breast cancer.

It is a potential cancer chemopreventive agent for breast cancer.Wiseman LR, Goa KL. Drugs Aging 9:292-306 (1996).

Kelloff GJ, Lubet RA, Lieberman R. Cancer Epidemiol Biomarkers Prev. 7:65-78 (1998).

F5770 Formononetin (See page 14 for more information) 100 mgC16H12O4 FW 268.26 [485-72-3] 500 mgNatural isoflavone having estrogenic activity. It binds to hER alpha and 1 gslightly induces transcription with hER beta. It was found to inhibit lecithin peroxidation induced

by superoxide anion generation by xanthine-xanthine oxidase.Morito K, Aomori t, Hirose T et al. Biol Pharmaceutical Bull. 25:48-52 (2002).

Toda S, Shiratake Y. Phytother Res. 13:163-165 (1999).

F5868 Formoterol Fumarate 10 mg

(C19H24N2O4)2C4H4O4.2H2O FW 840.91 [43229-80-7] 50 mg

Long-acting beta2-adrenergic agent that induces apoptosis through an

adrenoreceptor- and cAMP-independent, Ca2+-dependent mechanism. Antiasthmatic.

Mamani-Matsuda M, Moynet D, Molimard M et al. Br J Haematol. 124:141-50 (2004).

Tashkin DP, Cooper CB. Chest.125:249-59 (2004).

F5869 N-Formyl -Met-Ala-Ser 1 mgC12H21N3O6S FW 335.38 [17351-32-5] 2 mg

5 mg

F5870 N-Formyl-Met-Leu-Phe 5 mgC21H31N3O5S FW 437.6 [59880-97-6] 10 mgA bacterial chemotactic peptide. 25 mgAnton P, O'Connell J, O'Connell D et al. Gut. 42:374-379 (1998).

H

CH3

HH

O

O

CH3

OH

OHO

O

OCH3

Phe-Met-Arg-Phe-NH2

pGlu-Asp-Pro-Phe-Leu-Arg-Phe-

NH2

For-Met-Ala-Ser-OH

For-Met-Leu-Phe-OH

P(O2Ca)O

O


F5871 N-Formyl-Met-Leu-Phe-Lys 5 mgC27H43N3O6S FW 565.74 [104180-18-9] 10 mg

25 mg

F5872 N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys 5 mgC43H65O7N9 FW 824.04 [71901-21-8] 10 mg

25 mg

F5668 Forskolin 1 mgC22H34O7 FW 410.50 [66575-29-9] 5 mgActivator of adenylate cyclase. 10 mgLaurenza A et al. Trends Pharm Sci. 10:442-7 (1989).

Barber R, Goka TJ. J Cyclic Nucleotide Protein Phos. Res. 10:23-9 (1985).

F5873 Foscarnet sodium 1 gCNa3O5P FW 191.95 [63585-09-1] 5 gAnti-viral medication used to treat herpes viruses. Structural mimic of the anion 10 gpyrophosphate the selectively regulates DNA polymerase.Yu, Yan-yan. Zhonghua Ganzangbing Zazhi (2006), 14(11), 814-816.

F5874 Fosfomycin Calcium 5 gC3H5CaO4P FW 176.12 [26016-98-8] 25 gActs by inhibiting bacterial wall synthesis by inactivating the enzyme pyruval transferase.

Used for treated urinary tract infections and as a wide spectrum antibiotic transferase. Fujita M. The Japanese journal of antibiotics (1975), 28(3), 314-9.

F5773 Fosinopril sodium 25 mgC30H45NO7P .Na FW 585.64 [88889-14-9] 100 mgAn angiotensin-converting enzyme inhibitor shown to protect the organs in 250 mgsinoaortic-denervated rats.Duchin KL, Waclawski AP, Tu JI et al. J Clin Pharmacol. 31:58-64 (1991).

Tao X, Liu GL. Yao Xue Xue Bao. 38:743-747 (2003).

F5976 Fotemustene 5 mgC9H19ClN3O5P FW 315.69 [92118-27-9] 25 mgis a nitrosourea alkylating agent that is being investigated for use in the 100 mg treatment of melanoma.Tas, F., Cancer Chemotherapy and Pharmacology (2008), 62(2), 293-298

F7657 Ftorafur 250 mg5-Fluoro-1-(tetrahydro-2-furyl)uracil, tegafur 1 gC8H9FN2O3 FW 200.17 m.p. 167-1690C [17902-23-7]A clinically used antitumor agent related to 5-fluorouracil. Often used in combination with other antineoplastic drugs.Zhuk R. Adv Exp Med Biol. 431:677-80 (1998).

Ron IG, Lotan A, Inbar MJ, Chaitchik S. Anticancer Drugs. 7:649-54 (1996).

F8147 Fulvestrant 5 mgC32H47F5O3S FW 606.77 [129453-61-8] 25 mgA synthetic estrogen receptor antagonist. In vitro studies indicate that fulvestrant 100 mgreversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human

breast cancer cell lines.Kansra S, Yamagata S, Sneade L, et al. Mol. Cell Endocrinol. 239:27-36 (2005).

F8048 Fumagillin 1 mgAmebacilin, fugillin, fumadil B 5 mgC26H34O7 FW 458.54 [23110-15-8]Antibiotic produced by Aspergillus fumigatus. It is an antiprotozoal. Commonly used

to control nosema apis in honey bees. It was found to have antineoplastic activity. Stepiel H, Grochal M, Zielinski KW. Journal of Endocrinology. 150:99-106 (1996).

Rodriguez-Nieto S, Medina MA, Quesada AR. Anticancer Res. 21:3457-3460 (2001).

O

O

O

OH

H OH

OH

O

H3C

CH3

O

O

O

O

H3C

H

CH3

H

OH

O

O

For-Met-Leu-Phe-Lys-OH

For-Nle-Leu-Phe-Nle-Tyr-Lys-

OH

NH

N

O

N O

Cl

P O

EtO

EtO

N

O

O

O

P

O

O

O

CH3

CH3

O

CH3

Na

H H

H

OH

S

O F

F

F

FFHO

P(O2Ca)O

O


F8149 Fumonisin B1 1 mgC34H59NO15 FW 721.8 [116355-83-0] 5 mgMycotoxin from Fusarium moniliforme. Induces apoptosis in rat and monkey kidney cells.

Wang W, Jones C, Ciacci-Zanella J et al. Proc. Natl Acad Sci. USA. 93:3461-5 (1996).

Tolleson WH, Dooley KL, Sheldon WG. Adv. Exp Med Biol. 392:237-50 (1996).

F8150 Fumonisin B2 1 mgC34H59NO14 FW 705.8 [116355-84-1] 5 mg

F8270 Furosemide 5 gC12H11ClN2O5S FW 330.74 [54-31-9] 10 gA potent diuretic; antihypertensive. Found to have anti-inflammatory effect 25 gthrough inhibition of cytokines and tumor necrosis factor-alpha.

Prandota J. Am J Ther. 9:317-28 (2002).

Cavaliere F, Masieri S. Curr Drug Targets. 3:197-201 (2002).

F8272 Fusarenon X 1 mgC17H22O8 FW 354.35 [23255-69-8] 5 mgA trichothecene mycotoxin from fusarium.Masuda E, Takemoto T, Tatsuno T, et al. Immunology 45:743-749 (1982).

G0000 G250.A2 1 mg

C45H72N14O12 FW 1001.16 2 mg5 mg

G0048 GABA, Gamma-amino butyric acid 10 gg-Amino-n-butyric acid 25 gC4H9NO2 FW 103.12 [56-12-2] 100 gThe major inhibitory neurotransmitter in the mammalian central nervous system.

Chebib M, Johnston GA. Clin Exp Pharmacol Physiol 26:937-40 (1999).

G0106 Gabapentin (See page 21 for more information) 10 mgNeurontin 50 mgC9H17NO2 FW 171.24 [60142-96-3] 250 mgAn antiepileptic agent that is chemically related to g-aminobutyric acid (GABA).

Goa KL, Sorkin EM. Drugs. 46:409-27 (1993).

G0104 Gabexate mesylate 10 mgC16H24N3O4

.CH3O3S FW 417.48 [56974-61-9] 100 mgA serine protease inhibitor which is used therapeutically in the treatment of 250 mgpancreatitis

Yuksel M, Okajima K, Uchiba M, Okabe H (2003). J. Pharmacol. Exp. Ther. 305 (1): 298–305.

G0144 Galactosamine 500 mgC6H13NO5 FW 179.17 [7535-00-4] 1 gAn aminosugar isolated from chondroitin sulfate. 5 gIt is an inducer of apoptosis in hepatocytes.

Leist M, Gantner F, Jilg S, Wendel A. J Immunol. 154:1307-16 (1995).

Itokazu Y, Segawa Y, Inou N, Omata T. Biol Pharm Bull. 22:127-30 (1999).

G0146 Galanin, human 1 mgC139H210N42O43 FW 3157.44 [119418-04-1]Galanin is a neuropeptide found to be associated with Alzheimer's disease.

Counts SE, Perez SE, Ginsber SD et al. Mol Interv. 3:137-56 (2003).

HN

SH2N

O

COOH

ClO O

H2N COOH

His-Leu-Ser-Thr-Ala-Phe-Ala-

Arg-Val

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-

Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-

Gly-Asn-His-Arg-Ser-Phe-Ser-

Asp-Lys-Asn-Gly-Leu-Thr-Ser

OOH

H

H

OH

H

NH2H

OH

CH2OH

H

O

OHO

HO

O

O

OH

O

O

O

O

O

HN NH3

NH

SO

O

O

OO

OHO OH

O

O

OOHO

HO

O

OH OH

NH2

OCOOH

H3C O CH3 OH

OH OH

NH2

COOH

O

COOH

COOH

O

P(O2Ca)O

O

www.lktlabs com 129 To Order Call 1-888-558-5227

G0147 Galanin, porcine 1 mgC1 6H213N 3O 0 FW 3210 55 [88813-36-9]

G0148 Galanin, rat 1 mgC1 1H211N 3O 1 FW 3164.48 [114547-31-8]

G0246 Galantamine Hydrobromide 5 mgC17H21NO3

.HBr FW 368.27 [1953-04-4] 25 mgA cholinesterase inhibitor used in the treatment of Alzheimer's disease. 100 mgPotentiates nicotine-evolved increases in intracellular Ca2 and [3H]noradrenaline release.

Sweeney JE Puttfarcken PS Coyle JT. Pharmacol Biochem Behav. 34 129-37 (1989).

Lilienfeld S. CNS Drug Rev. 8 159-76 (2002).

Dajas-Bailador FA Heimala K Wonnacott S. Mol Pharmacol. 64 1217-26 (2003).

G0044 Galantide 0.5 mgC10 H151N25O26S FW 2199.58 [138579-66-5] 1 mgActs as a reversible antagonist to the neuropeptide galanin. 2.5 mgBartfai T Bedecs K Land T et al. Proc Natl Acad Sci U S A. 88 10961-10965 (1991).

Lindskog S Ahren B Land T et al. Eur J Pharmacol. 210 183-188 (1992).

G0145 Gallic acid 10 g3,4,5-Trihydroxybenzoic acid 100 gC7H6O5 FW 170.12 [149-91-7] 500 gInduces apoptosis in human lung cancer cells. It is cytotoxic to PC14 AND MKN45 human

cancer cell lines.

Ohno Y Fukuda K Takamura G Toyota M. Anticancer Drugs.10 845-51 (1999).

Lee IR Yang MY. Arch Pharm Res. 17 476-9 (1994).

G0243 (-)-Gallocatechin 5 mgC15H1 O7 FW 306.27 [3371-27-5] 10 mgPolyphenolic compound found in green tea. An epimer of (−)-epigallocatechin. 25 mgGuo Q Zhao B Shen S et al. Biochim. Biophys. Acta. 1427 13-23 (1999).

G0245 Gallocatechin Gallate 5 mgC22H18O11 FW 458 37 [4233-96-9] 10 mgNatural product from green tea. It is the ester of gallocatechin and gallic

acid. It is a type of catechin.

Ikeda I Kobayashi M Hamada T et al. J. Agric. Food Chem. 51 7303-7307 (2003).

G0152 Ganciclovir 50 mgC9H13N5O FW 255.23 [82410-32-0] 100 mgNucleoside analog used to disrupt DNA replication.Matthews T Boehmw R. Rev. Infect Dis 10 Suppl 3 S490-4 (1988).

G0175 Gastric Inhibitory Peptide (GIP), human 0.5 mgC226H338N60O66S FW 4983 64 [100040-31-1] 1 mg

2.5 mg

G0180 Gastrin I, human 1 mgC130H20 N38O31S2 FW 2098.22 [10047-33-3] 2 mgA growth factor for established tumors that stimulates the growth of gastric 5 mg mucosa.Watson SA Morris TM Varro A et al. Gut. 45 812-817 (1999).

Konda Y Kamimura H Yokota H et al. Am J Physiol. 277 G773-G784 (1999).

he eu-P H s-Val Phe-Ala-

H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-

Gly-Tyr-Leu-Leu-Gly-Pro-Gln-

Gln-Phe-Phe-Gly-Leu-Met-NH2

pGlu-Gly-Pro-Trp-Leu-Glu-Glu-

Glu-Glu-Glu-Ala-Tyr-Gly-Trp-

Met-Asp-Phe-NH2

N

O

H3CO

OH

CH3

HBr

COOH

OHHO

OH

H-Tyr-Ala-Glu-Gly-Thr-Phe-Ile-

Ser-Asp-Tyr-Ser-Ile-Ala-Met-

Asp-Lys-Ile-His-Gln-Gln-Asp-

Phe-Val-Asn-Trp-Leu-Leu-Ala-

Gln-Lys-Gly-Lys-Lys-Asn-Asp-

Trp-Lys-His-Asn-Ile-Thr-Gln-OH

OHO

OH

O

OH

OH

OH

OOH

OH

OH


Tyr-Leu-Leu-Gly-Pro-H s-Ala-Ile-

Asp-Asn-His-Arg-Ser-Phe-H s-

Asp-Lys-Tyr-Gly-Leu-Ala-NH2


Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-

Asp-Asn-His-Arg-Ser-Phe-Ser-

Asp-Lys-His-Gly-Leu-Thr-NH2


G0178 Gastrin, chicken 0.5 mgC190H265N 7O51S1 FW 4055.58 1 mg

2.5 mg

G0179 Gastrin-1, rat 0.5 mgC9 H128N22O31S2 FW 2126.32 [81123-06-0] 1 mg

2.5 mg

G0181 Gastrin Releasing Peptide, human 1 mgC130H20 N38O31S2 FW 2859.40 [93755-85-2]GRP regulates tumor proliferation and metastasis in a number of gastrointestinal cancers.Levine L Licci JA 3rd Townsend CM Jr et al. J Am Coll Surg. 196 898-904 (2003).

G0182 Gastrin Releasing Peptide, porcine 1 mgC126H198N38O31S2 FW 2805.40 [74815-57-9]

G0278 Gatifloxacin (See page 16 for more information) 500 mgC19H22FN3O FW 375.39 [112811-59-3] 1 gA fluoroquinolone that has an 8-methoxy group, which contributes to its 5 g selectivity as an antibacterial agent.Fukuda H Kishii R. Takei M Hosaka M. Antimicrob Agents Chemother. 45 1645-53 (2001).

G0096 G-A-Y 5 mgC1 H19N3O5 FW 309.18 [69537-64-0] 10 mg

25 mg

G1721 Gefitinib (See page 24 for more information) 100 mgC22H2 ClFN O3 FW 446.90 [184475-35-2] 250 mgA drug used in the treatment of certain types of cancer. Acting in a similar manner 1 g to erlotinib, gefitinib selectively targets the mutant proteins in malignant cells.Boehrer S. Biochemical Pharmacology (2008) 76(11) 1417-1425.

G1646 Geldanamycin 100 µgC29H 0N2O9 FW 560.64 [30562-34-6] 5 x 100 µgA benzoquinoid ansamycin antibiotic having antitumor activities. Suppresses 1 mgDNA replication by inhibiting c-myc gene expression in lymphoblastoma L5178Y cells.

It inhibits tyrosine kinases and induces increased p53 protein involved in cell-cycle arrests of human ovarian tumor cells. It inhibits the 90 kDa heat shock protein that regulates cell signal transduction, telomerase activity, and induces apoptosis.Yamaki H Iguchi-Ariga SM Ariga H. J Antibiot (Tokyo). 42 604-10 (1989).

McIlwrath AJ Brunton VG Brown R. Cancer Chemother Pharmacol. 37 423-8 (1996).

Villa R Folini M Porta CD et al. Carcinogenesis. 24 851-9 (2003).

Kim S Kang J Hu W. Int J Cancer. 103 352-9 (2003).

G1745 Gemcitabine Hydrochloride (See page 5 for more info) 25 mgC9H12ClF2N3O FW 299.66 [122111-03-9] 100 mgA deoxycytidine-analogue antimetabolite that has demonstrated activity against non-small cell lung cancer, pancreatic cancer, ovarian cancer, and breast cancer.Hui YF Reitz J. Am J Health Syst Pharm. 54 162-170 (1997).

G1749 Gemfibrozil 5 g2,2-Dimethyl-5-(2,5-xylyoxy) valeric acid 25 gC15H22O3 FW 250.33 [25812-30-0]A hyperlipidemic agent that elevates plasma HDL and lowers triglycerides and LDL bystabilizing apoA-I mRNA transcripts. It was found to inhibit inducible nitric oxide synthase by inhibiting the activation of nuclear factor-kappaB, activator protein-1 and CCAAT/enhancer-binding proein beta.Goto D Okimoto T Ono M et al. Arter. Throm Vas Biol. 17 2707-1712 (1997).

Pahan K Jana M Liu X et al. J Biol Chem. 277 45984-45991 (2002).

CH3

H3C O

CH3

CH3

COOH

O

O

H

CH3

NH

O

CH3

O

H3CO

H3C

H3C

H3CO

OCONH2

H3CO

H-Phe-Leu-Pro-His-Val-Phe-Ala-

Glu-Leu-Ser-Asp-Arg-Lys-Gly-

Phe-Val-Gln-Gly-Asn-Gly-Ala-Val-

Glu-Ala-Leu-His-Asp-Phe-Tyr-

Pro-Asp-Trp-Met-Asp-Phe-NH2

H-Gly-Ala-Tyr-OH

pGlu-Arg-Pro-Pro-Met-Glu-Glu-

Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-

Asp-Phe-NH2

Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-

Thr-Val-Leu-Thr-Lys-Met-Tyr-Pro-

Arg-Gly-Asn-His-Trp-Ala-Val-Gly-

His-Leu-Met-NH2

Ala-Pro-Val-Ser-Val-Gly-Gly-Gly-

Thr-Val-Leu-Ala-Lys-Met-Tyr-Pro-


H s-Leu-Met-NH2

O

FOH

FHO

N

N

NH2

O

HCl

www lktlabs.com 131 To Order Call 1-888-558-5227

G1853 Genipin 25 mgC11H1 O5 FW 226.23 [6902-77-8] 100 mgFound in the gardenia fruit extract, which is used in traditional Chinese medicine to

relieve the symptoms of type 2 diabetes.

Chan CB De Leo D Joseph JW et al. Diabetes 50 1302-1310 (2001).

G1650 Geniposide 10 mgC17H2 O10 FW 388 37 [24512-63-8] 25 mgNatural product isolated from the fruit of Gardenia. It was found to induce 100 mgincreased activity of phase II detoxifying enzymes, inhibit tumor promotion, and

induce apoptosis in rat C6 glioma cells.

Wang CJ Wang SW Lin JK. Cancer Letters. 60 95-102 (1991).

Lee MJ Hsu JD Wang CJ. Anticancer Res. 15 411-416 (1995).

Chang YC Tseng TH Lee MJ. Chemico-Biol Interactions. 141 243-257 (2002).

G1652 Genistein (See page 14 for more information) 100 mgC15H10O5 FW 270.24 [446-72-0] 500 mgAn isoflavone with anticancer, antiproliferative, and chemopreventive effects. 1 gIt induces cell differentiation and inhibits metabolic activation of benzo[a]pyrene.

Chae Y-H Ho DK Cassady JM et al. Chem. Biol. Int. 82 181-193 (1992).

Jing Y Waxman S. Anticancer Res. 15 1147-1152 (1995).

G1653 Genistin 1 mgC21H20O10 FW 432.38 [529-59-9] 5 mgGlucoside of Genistein exhibiting cytotoxic effects in vitro. Genistin is an inhibitor

of protein tyrosine kinase and DNA toposomerase. Shaoquan et. al. J of Nutri. 129 1291-1297 (1999).

G1658 Gentamycin sulfate 500 mgFW 551.73 [1405-41-0] 1 gAntibiotic from fermentation. 5 gBlack J et al. Antimicrob. Ag. Chemother. 138-137 (1963). 10 g

G1869 Geranylgeraniol 25 mgC20H3 O FW 290.49 [24034-73-9] 100 mgA polyprenyl alcohol found to induce apoptosis in various human tumor cell lines.

Ohizumi H Masuda Y Yoda M et al. Abticancer Res. 17 1051-7 (1997).

Yaguchi M Miyazawa K Katagiri T et al. Leukemia 11 779-87 (1997).

G1975 Gestrinone 25 mgC21H2 O2 FW 308.41 [16320-04-0] 100 mgA synthetic steroid hormone. It has anti-progestin and androgenic activity. 500 mgTamaya T Fujimoto J Watanabe Y et al. Acta. Obstet. Gynecol. Scand. 65 439-441 (1986).

G2368 G-F-R 5 mgC17H26N6O FW 387.4 10 mg

25 mg

G2868 Ghrelin, human 1 mgC1 9H2 9N 7O 2 FW 3370.9 [258279-04-8] 5 mgA gastric peptide hormone that regulates growth hormone secretion. It has been shown to

exert MAPK-mediated proliferogenic and antiapoptotic effects in cultured human adrenal

zona glomerulosa cells.

Mazzocchi G Neri G Rucinski M et al. Peptides. 25 1269-77 (2004).

O

OOH

HO

OH

O

OOH

O

OH

O

CH2OH

OH

OH

OH

O

O OCH3

HOH2CO

H

HO

OHOH2C

HOHO OH

Se (n ano ) Phe

Gly-Ser-Ser(n-octanoyl)-Phe-

Leu-Ser-Pro-Glu-His-Gln-Arg-

Val-Gln-Gln-Arg-Lys-Glu-Ser-

Lys-Lys-Pro-Pro-Ala-Lys-Leu-

Gln-Pro-Arg

H-Gly-Phe-Arg-OH


G2869 Ghrelin, rat 1 mgC1 7H2 5N 5O 2 FW 3314.8 5 mg

G2870 GHRF (1-44), human 0.5 mgC215H358N72O66S1 FW 5039.7 [83930-13-6] 1 mg

2.5 mg

G2874 GHRF, rat 0.5 mgC225H361N77O66S FW 5232.93 [86472-71-1] 1 mg

2.5 mg

G2871 GHRF, bovine 0.5 mgC220H366N72O66S1 FW 5107.88 [88894-91-1] 1 mg

2.5 mg

G2873 GHRF, ovine 0.5 mgC221H368N72O66S1 FW 5121.9 [94948-82-0] 1 mg

2.5 mg

G2872 GHRF, mouse 0.5 mgC220H365N69O6 S1 FW 5032.85 1 mg

2.5 mg

G2968 GHRP-2 0.5 mgC 5H5 O6N9 FW 818.0 [158861-67-7] 1 mg

2.5 mg

G2969 GHRP-6 1 mgC 6H56N12O6 FW 873.04 [87616-8-0] 2 mg

5 mg

G3352 Ginkgolic acid (13:0) 1 mgC20H32O3 FW 320.47 [20261-38-5] 5 mgIsolated from ginkgo sarcotestas, Ginkgolic acid inhibits growth of tumor cells and

normal cells in vitro.Yang X Qian Z Chen J et al. Zhong Yao Cai. 27 40-42 (2004).

G3353 Ginkgolic acid (15:1) 1 mg Romanicardic acid 5 mgC22H3 O3 FW 346.50 [22910-60-7]

Natural product isolated from ginkgo biloba.

G3351 Ginkgolic acids Mixture 5 mg25 mg


G3354 Ginkgolide A 10 mgC20H2 O9 FW 480.40 [15291-75-5] 25 mgOne of a group of cage molecules isolated from the leaves of the Ginkgo biloba 50 mg tree. A highly active platelet-activating factor (PAF) antagonist. A potential

therapeutic agent in a variety of immunological and inflammatory disorders.

Braquet P Esanu A Buisine E et al. Medicinal Res. Reviews 1 295-355 (1991).

Wada K Sasaki K Miura K et al. Biol. Pharm. Bull. 16 210-212 (1993).

G3355 Ginkgolide B 10 mgC20H2 O10 FW 424.40 [15291-77-7] 25 mgOne of a group of cage molecules isolated from the leaves of the Ginkgo biloba 50 mg tree. A highly active platelet-activating factor (PAF) antagonist. A potential

therapeutic agent in a variety of immunological and inflammatory disorders.Braquet P Esanu A Buisine E et al. Medicinal Res. Reviews. 11 295-355 (1991).

Brochet B Guinot P Orgozo JM et al. Psychiatry. 58 360-362 (1995).

Cheng D Chen W. Chin. Med. J. 109 881-884 (1996).

G3356 Ginkgolide AB 25 mgA mixture of Ginkgolide A and Ginkgolide B. 50 mgBraquet P Esanu A Buisine E et al. Medicinal Res. Reviews 11 295-355 (1991).

G3357 Ginkgolide C 10 mgC20H2 O11 FW 440.40 [15291-76-6] 25 mgNatural product from Ginkgo Biloba. 50 mg

G3359 Ginkgolide J 1 mgC20H2 O10 FW 424.40 [107438-79-9] 5 mgFound in Ginkgo biloba, Ginkgolide J was found to reduce apoptotic damage in cultured

chick embryonic neurons.

Ahlemeyer B Krieglstein J. Pharmacopsychiatry. 36 Suppl 1 S8-14 (2003).

G3358 Ginkgolides 100 mgMixture of Ginkgolides A, B and C. 500 mg

1 g

Ginsenosides (See page 9 for more information)

Ginsenosides are active ingredients isolated from the oriental herb, ginseng. They are

steroidal saponins. Many ginsenosides have been found to have anticancer properties

against tumor cell lines and tumor growth. Others have been shown to have CNS

effects ranging from protecting neurons from ischemic damage to preventing

scopolamine-induced memory deficits. The following is a complete list of ginsenosides

related compounds.

G3460 Ginsenoside F1 1 mgC36H62O9 FW 638.87 [53963-43-2] 5 mg

10 mg

OO

H

H3COH

O

H

O

O

O

O

HO H

H

CH3

CH3

CH3

H

OO

H

H3COH

H

O

H

O

O

O

OH

O

HO H

H

CH3

CH3

CH3

H

O

O

O

H

CH3

H

HH

O

O

O

CH3

CH3

CH3

H OH

H

O

HO

H

OH

HOH

OH

HO

O

OH

O

OH

HO

HO

OH

HO

H

O

OOO

CH3OH

H

O

OH

O

O

CH3

H3C CH3

HO


G3461 Ginsenoside F2 1 mgC 2H72O1 FW 801.01 [62025-49-4] 5 mg

10 mg

G3462 Ginsenoside F3 1 mgC 1H70O13 FW 770.99 5 mg

10 mg

G3454 Ginsenoside Rb1 5 mgC5 H92O23 FW 1109.29 [41753-43-9] 10 mg

25 mg

G3553 Ginsenoside Rb2 5 mgC53H90O22 FW 1079.27 [11021-13-9] 10 mg

25 mg

G3554 Ginsenoside Rb3 5 mgC53H90O22 FW 1079.27 [68406-26-8] 10 mg

25 mg

G3455 Ginsenoside Rc 1 mgC53H90O22 FW 1079.27 [11021-14-0] 5 mg

10 mg

G3456 Ginsenoside Rd 1 mgC 8H82O18 FW 947.15 [52705-93-8] 5 mg

10 mg

G3457 Ginsenoside Re 1 mgC 9H8 O17 FW 947.18 [52286-59-6] 5 mg

10 mg

OH

O

O

OH

O

OH

HO

HO

OH

O

OH

HO

HO

OH

OH

HO

O

OH

O

OH

HO

HO

O

OH

HO

H

O

OH

CH3CH3 H

H

CH3

CH3

CH3

O

O

OH

OH

HO

OH

OH

H

H OH

O

OH

H

H OH

O

OH

OH

H

H OH

O

H3

H

CH3

CH3

H

OH

3H3 H

O CH3

CH3

CH3

H

OH

OH

CHO

OH

OH

O

O

OH

H OH

O

OH

H

OH

H OH

O

O

H C

H3

H3

OH

H

H

H3H3

H3

H3

3

H

H

H2

H

H

H

H

H2 H

H

H

H

H2 H

H3

H

H3

3

H

H

O

OH

O

OH

CH2OH

O

OHOH

OH

H2OH

O

OH

OH

OH

H2OOH

H

H

OH

3H3 H

H

CH3

CH3

CH3

O

OH

OH

OH

CH2

O

OH

OH

H2OH

O

OH

OH

H

CH2OH

HO

O

H3C

H

CH3

CH3

H

OH

H33

H

CH3

CH3

CH3

OH

OH

OH

H2HO

H3C

H

CH3

H3

O

OH

O

H

CH2OH

O

OHOH

CH3

OH

C 3H O


G3458 Ginsenoside Rg1 5 mgC 2H72O1 FW 801.01 [22427-39-0] 10 mg

25 mg


10 mg

G3552 20(S)-Ginsenoside Rg3 5 mgC 2H72O13 FW 785.01 10 mgGinsenoside Rg3 has been shown to affect endothelium-dependent relaxation in 25 mgthe aorta.

Kim N.; Kang S.; Park J.; Achini-Kerth V. Eur. J. Pharmacol. 12 41-49 (1999).


25 mg

G3557 Ginsenoside Rh1 5 mgC36H62O9 FW 638.87 [63223-86-9] 10 mg

25 mg

G3453 Ginsenoside Rh2 1 mgC36H62O8

.H2O FW 640.89 [78214-33-2] 5 mgIs a plant glycoside with a dammarane skeloton resembling a steroid skeleton. It 10 mghas antiproliferation, differentiation and chemopreventive effects in certain 25 mgcancer cell types. It was found to induce apoptosis in rat glioma C6Bu-1 cells, human neuroblastoma SK-N-BE 2 cells and human ovarian cancer cell lines.Oh M Choi YH Choi S Chung H et al. Int J Oncol. Int 14 869-75 (1999).

Kim Ys Jin Sh Lee YH et al. Arch Parm Res. 22 448-53 (1999).

Kim YS jin SH Lee YH et al. Arch Pharm Res. 23 518-24 (2000).

Nakata H Kikuchi Y Tode T et al. Jpn J Cancer Res. 89 733-40 (1998).

G3558 20(R)-Ginsenoside Rh2 1 mgC36H62O8 FW 622.87 5 mgIt is isolated from the root Panax ginseng. It has an anti-cancer proliferation, 10 mgdifferentiation and chemopreventive effects in certain cancer cell types. It was found 25 mgto induce apoptosis in rat glioma C6Bu-1 cells, human neuroblastoma SK-N-BE 2

cells and human ovarian cancer cell lines.Oh M.; Choi Y.; Choi S.; Chung H. et al. Int. J. Oncol. 14 869-75.Kim YS Jin SH Lee YH Park JD Kim SI Arch. Pharm. Res. 23 518-24 (2000).

H

CH3CH3 H

H

O CH3

CH3

CH3

O

OH

OH

OH

CH2OH

HO

H3C

H

CH3

CH3O

H

HOOH

OH

CH2OH

H

OH

CH3CH3 H

H

HO CH3

CH3

CH3

HO

H3C

H

CH3

CH3

O

OH

O

H

H2OH

O

OH

O

OH

CH3

OH

HO

H3C

HO

CH3 CH3

OH

H

H CH3

H

CH3

OO

OH

OH

OH

HO

O CHO


N5778 Notoginsenoside R1 5 mgC 7H80O17 FW 919.10 10 mg

25 mg

P0253 Panaxadiol 5 mgC30H52O3 FW 460.73 10 mg

25 mg

P0254 Panaxatriol 5 mgC30H52O FW 476.73 10 mg

25 mg

P6957 Protopanaxadiol 5 mgC30H52O3 FW 460.73 10 mg

25 mg

P6958 Protopanaxatriol 5 mgC30H52O FW 476.73 10 mg

25 mg

P7318 Pseudoginsenoside F11 5 mgC 8H82O19 FW 963.15 10 mg

25 mg

G4532 Gliclazide 1 gC15H21N3O3S FW 323.41 [21187-98-4] 5 gInhibits monocyte adhesion in type 2 diabetes and increases free radical 10 g scavenging.

Holmes B Heel R Brogden RN et al. Drugs 27 301-27 (1984).

O Brien RC Luo M Balazs N Mercuri J. J Diabetes Complications. 14 201-6 (2000).

G4535 Glimepiride 500 mgC2 H3 N O5S FW 490 62 [93479-97-1] 1 gA sulfonylurea hypoglycemic agent acts with the lowest ratio of insulin release to 5 g glucose release when compared with other sulfonylureas. It increases cardiac glucose

uptake by enhancing protein expression of glucose transports -1 and -4 independent of insulin responsiveness.Bahr M von Holtey M Muller G Eckel. J. Endocrinology. 136 2547-53 (1995).

Schiekofer S Rudofsky G Jr Andrassy M et al. Diabetes Obes Metab. 5 251-61 (2003).

H

OH

CH3CH3 H

H

HO CH3

CH3

CH3

HO

H C

H

CH3

CH3OH

H

OH

CH3CH3 H

H

HO CH3

CH3

CH3

HO

H3C

H

CH3

CH3

H

OH

H33 H

H

O CH3

CH3

CH3

HO

H3C

H

CH3

CH3O

O

HO

HO

HO

OH

O

O

OH

OH

CH2OH

O

HOHO

H

OH

CH3CH3 H

H

HO

H3C

H

CH3

CH3

O

H

OH

CH3CH3 H

H

HO

CH3

H

CH3

CH3OH

O

H

H

CH3CH3 H

H

C 3

H

H3

H3

O

O

OH

O

OH

OH

CH2OH

OHH

H3

H

OH

OH

H2HO


G4434 Gliotoxin 1 mgC13H1 N2O S2 FW 326.39 [67-99-2] 5 mgA sulfur containing antibiotic. Possesses immunosuppressive properties as it 10 mg may suppress and cause apoptosis. Acts as an inhibitor of farnesyl transferase.

Hur Jung-Mu. Journal of cellular biochemistry (2008) 104(6) 2174-84.

G4634 Glipizide (See page 21 for more information) 500 mgC21H27N5O S FW 445.54 [29094-61-9] 1 gAn oral hypoglycemic agent that enhances insulin secretion by inhibiting its 5 g metabolic clearance. It blocks ATP-dependent K channels in pancreatic b cells

and brain GABA containing neurons resulting in insulin release.

Barzilai N Groop PH Groop DeFronzo RA. Acta Diabetol. 32 273-8 (1995).

Brogden RN Heel RC Pakes GE et al. Drugs. 18 329-53 (1979).

Lamensdorf I He L Nechushtan A et al. Eur J Pharmacol. 388 147-54 (2000).

G4480 Glucagon, human 1 mgC153H225N 3O 9S FW 3482.78 [16941-32-5]

An essential hormone that increases cAMP in hepatocytes, shown to reduce iNOS expression.

Harbrecht BG Perpetua M Fulmer M et al. Shock. 22 157-62 (2004).

G4479 Glucagon (19-29), human 1 mgC61H89N15O18S FW 1352.54 [64790-15-4] 2 mg

5 mg

G4481 Glucagon-Like Peptide I (7-36), amide, human 0.5 mgC1 9H229N 0O 5 FW 3297.7 [107444-51-9] 1 mgEffector in the hormonal control of insulin secretion. 2.5 mgBell GI Sanchez-Pescador R Laybourn PJ Najarian RC. Nature. 304 368-371 (1983).

G4482 Glucagon-Like Peptide I (7-37); GLP-1 (7-37) 0.5 mgC151H228N 0O 7 FW 3355.67 [106612-94-6] 1 mg

2.5 mg

G4483 Glucagon-Like Peptide II, human 0.5 mgC171H266N 8O56S FW 3922.38 [223460-79-5] 1 mg

2.5 mg

G4484 Glucagon-Like Peptide II, rat 0.5 mgC166H256N O56S FW 3796.22 [195262-56-7] 1 mg

2.5 mg

G4485 [Ala19] Glucagon-Like Peptide II, rat 0.5 mgC165H25 N O55S FW 3766.2 [89750-15-2] 1 mg

2.5 mg

O

N

N

NH

NH

NH

H3C

O

O OO

H-His-Ala-Asp-Gly-Ser-Phe-Ser-

Asp-Glu-Met-Asn-Thr- le-Leu-

Asp-Asn-Leu-Ala-Ala-Arg-Asp-

Phe-Ile-Asn-Trp-Leu- le-Gln-

Thr-Lys- le-Thr-Asp-Arg-OH


Asp-Glu-Met-Asn-Thr- le-Leu-

Asp-Asn-Leu-Ala-Thr-Arg-Asp-

Phe- le-Asn-Trp-Leu- le-Gln-

Thr-Lys- le-Thr-Asp-OH


Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-

Asn-Leu-Ala-Thr-Arg-Asp-Phe-Ile-

Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-

Thr-Asp-OH

H-His-Ala-Glu-Gly-Thr-Phe-Thr-

Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-

Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-

Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-

OH

His-Ser-Gln-Gly-Thr-Phe-Thr-

Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-

Asp-Ser-Arg-Arg-Ala-Gln-Asp-

Phe-Val-Gln-Trp-Leu-Met-Asn-

Thr

H-Ala-Gln-Asp-Phe-Val-Gln-Trp-

Leu-Met-Asn-Thr-OH




Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

N

N

O

O

CH2OH

CH3

SSOH


G4518 Glucaric acid, calcium salt 25 gD-saccharic acid, calcium salt. 100 gC6H8O8Ca. H2O FW 320 3 [5793-89-5]It is a nontoxic, natural compound. One of its derivatives 1,4-GL increases detoxification of carcinogens and tumor promoters/ progressors by inhibiting β-glucuronidase

and preventing hydrolysis of their glucuronides. Walaszek Z Szemraj J Narog M et al. Cancer Detect Prev. 21 178-90 (1997).

Abou-Issa H Moeschberger M el-Masry W et al. Anticancer Res. 15 805-10 (1995).

G4781 Glucoraphanin Potassium Salt 5 mgC12H22KNO10S3 xH2O FW 475.60 (anhydrous basis) 10 mgA glucoraphanin analogue. Very hygroscopic 25 mg

G4782 Glucoraphenin Potassium Salt 5 mgC12H20KNO10S3 xH2O FW 473.58 (anhydrous basis) 10 mgA glucoraphanin analogue. Very hygroscopic

G4580 Glucosamine hydrochloride 25 gC6H13NO5

.HCl FW 215.6 [66-84-2] 100 gHydrochloride salt of glucosamine, an effective treatment for osteoarthritis pain. 500 gLu F Guo H. Wei Sheng Yan Jiu. 32 594-7 (2003).

G4581 Glucosamine sulfate 100 gC6H13NO5

.1/2H2SO FW 277.25 [29031-19-4] 500 g

An antiarthritic agent isolated from chitin. 1 kgSetnikar I Pacini MA Revel L. Arzneimittelforschung. 41 542-545 (1991).

G4584 L-Glutamine Please inquireC5H10N2O FW 146.14 [56-85-9]Glutamine is an abundant amino acid.

O Neil M. (ed.) The Merck Index 13th Ed. Merck & Co Inc. Whitehouse Station NJ 2001.

G4796 Glycerol Monolaurate 25 gC15H30O FW 274.40 [142-18-7] 100 gGlycerol Monolaurate has been shown to have antibacerial, antifungal, and

antiviral effects.

Lieberman S. M.G. Enig and H.G. Preuss. 2006. Alternative and Complementary Therapies.

G4596 Glycidamide 10 mgC3H5NO2 FW 87.08 [5694-00-8] 25 mgAn epoxide metabolite of acrylamide. It is neurotoxic and carcinogenic. 100 mgCosta LG Deng H Callema CJ Bergmark E. Toxicology 98 151-161 (1995).

G4798 Glycitein 5 mgC16H12O5 FW 284.26 [40957-83-3] 10 mgAn O-methylated isoflaone found in soy food products. A phytoestrogen with weak 25 mgestrogenic activity, comparable to that of the other soy isoflavones.

Song TT Hendrich S Murphy PA. J. Agric. Food Chem. 47 (4) 1607–10 (1999).

OOC C

OH

H

C

H

OH

C

OH

H

C

OH

H

COO

Ca

O

HOH2C

HO

HO

NH2

OH

HCl


G4799 Glycitin 5 mgC22H22O10 FW 446.40 [40246-10-4] 10 mgIsoflavone derivative found in soy-based food products.

Wang H. and Murphy P.A. J. Agric. Food Chem. 42 1666-1673 (1994).

G4597 18 β-Glycyrrhetinic Acid 5 gEnoxolone 10 gC30H 6O FW 470 68 m.p. 325-328oC [471-53-4] 25 gThe aglycone of the triterpenoid Glyccyrrhizic acid, with potent antitumor promoting activity.Kelloff GJ Boone CW Crowell JA et al. Cancer Epidemiol. Biomarkers Prev. 3 85-98 (1994).

G4598 Glycyrrhizic acid, ammonium salt, trihydrate 10 gGlycyrrhizin 25 gC 2H65NO16

.3H2O FW 894.03 m.p. 209-2110C [53956-04-0]A triterpenoid saponin with antiproliferative activity. Found to inhibit arylamine-N-acetyltransferase in Klebsiella pneumoniae.Lo HH Yen YS Hsieh SE Chung JG. J. Appl. Toxicol. 17 385-390 (1997).

G5752 Gonadorelin Acetate Please inquireC55H75N17O13

. 2(C2H O2) FW 1302.59 [71447-49-9]An LHRH agonist. Diagnosis of the hypothalamic-pituitary-gonadal axis function and cryptorchism. Use in reproduction medicine and ovarian follicular cysts (veterinary medicine).

G5772 Goserelin Acetate Please inquireC59H8 N18O1

. C2H O2 FW 1329.48 [145781-92-6]

Goserelin acetate is a potent LHRH agonist. For the treatment of advanced hormone-

dependent breast cancer, advanced hormone-dependent prostate cancer, endometriosis

and uterus myoma. Use in reproduction medicine.

G5874 Gossypol 25 mgC30H30O8 FW 518.55 [303-45-7] 100 mgA potential male anti-fertility agent from cotton that exhibits a wide spectrum of 250 mgtoxicity. It was found to have cytotoxic effects on human cancer cell lines. It is a potent telomerase inhibitor.Nadakavukaren MJ Sorensen RH Tone JN. Cell Tissue Res. 204 293-6 (1979).

Sakesena SK Salmonsen R Lau IF Chang MC. Contraception. 24 203-14 (1981).

Tuszynski GP Cossu G. Cancer Res. 44 768-71 (1984).

Mego M. Bratisl Lek Listy. 103 378-81 (2002).

G5875 Gossypol Acetic Acid 250 mgC30H30O8 FW 578.61 [12542-36-8] 1 g

G6000 gp38 1 mgC133H209N 1O38S2 FW 3054.53 2 mg

5 mg

G6368 G-P-R 5 mgC13H2 N6O FW 328.18 [47295-77-2] 10 mg

25 mg

HO

HO

H3C CH3

H O

OH

CH3

OH

OH

CH3H3C

HO

OH

H3C

H-Gly-Pro-Arg-OH

Glp-His-Tyr-Ser-Tyr-Gly-Leu-

Arg-Pro-Gly-NH2

Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-

Leu-Arg-Pro-AzaGly-NH2

H-Arg-Val-Thr-Ala- le-Glu-Lys-

Tyr-Leu-Gln-Asp-Gln-Ala-Arg-

Leu-Asn-Ser-Trp-Gly-Cys-Ala-

Phe-Arg-Gln-Val-Cys-OH



G6400 G-Q 5 mgC7H13N3O FW 203.2 [13115-71-4] 10 mg

25 mg

G6802 Granisetron 25 mg C18H2 N O FW 312.20 [109889-09-0] 100 mgThis compound has been used to successfully treat post operative nausea. 500 mgFujii Y Clin Drug Investig. 26(8) 427-37.(2006)

Rubenstein EB Slusher BS Rojas C Navari RM. Cancer J; 12(5) 341-7 (2006)

G6803 Granuliberin R 1 mgC69H103N19O1 FW 1422.71 [64704-41-2] 2 mgA histamine-releasing peptide originally isolated from the skin of Rana rugosa 5 mg that induces mast cell degranulation.Kozakiewicz M Godlewski A. Cell Mol Biol Lett. 8 727-734 (2003).

Lechago J Crawford BG Walsh JH. Neuroscience. 12 329-337 (1984).

G6817 Green tea polyphenols 10 g[84650-60-2] 20 gExtracts of green tea. Inhibitors of chemical carcinogenesis. 100 gWang Z Y Khan WA Bickers D Mukhtar H. Carcinogenesis. 10 411-5 (1989).

Yamane T Hagiwar N Tateishi M et al. Jpn. J. Cancer Res. 82 1336-39 (1991).

G6856 Growth Hormone Releasing Factor, human 1 mg C215H358N72O66S FW 5039.70 [83930-13-6]

G8101 Guaifenesin 25 gC10H1 O FW 198.22 [93-14-1] 100 gAn expectorant reported to have muscle relaxant and sedative activity. It is 500 goften used as anesthetic animal surgery.Muir WW Skarda RT Sheehan W. Am J Vet Res. 39 1274-8 (1978).

Dicpinigaitis PV Gayle YE. Chest. 124 2178-81 (2003).

G8103 Guanylin, human 0.5 mgC58H87N15O21S FW 1458.68 [145319-90-0] 1 mgAn endogenous activator of intestinal guanylate cyclase. 2.5 mgWiegand RC Kato J Currie MG. Biochem Biophys Res Commun. 185 812-817(1992).

G8104 Guanylin, rat, mouse 0.5 mgC60H90N16O22S FW 1515.74 [145257-03-0] 1 mg

2.5 mg

G8225 Guggulsterone 5 mgC21H28O2 FW 312.45 [95975-55-6] 25 mgIs a plant sterol found in the resin of the guggul plant, Commiphora mukul.Szarpary PO Wolfe ML Bloedon LT et al. J. Amer. Med. Assoc. 290 765-772 ( 2003).

H0001 H7/(-)-1-(5-Isoquinolinesulfonyl)-2- 10 mgmethylpiperazine, Di-HCl salt 25 mgC1 H17N3O2S.2HCl FW 364.40 [108930-17-2]Inhibitor of PKC, cAMP-dependent kinase, and cGMP-dependent kinase.

Kawamoto S Hidaka H. Biochem Biophys Res Comm. 125 258-64 (1984).

O OH

OCH3

OH

H-Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-

Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH


H-Gly-Gln-OH

H-Phe-Gly-Phe-Leu-Pro-Ile-Tyr-

Arg-Arg-Pro-Ala-Ser-NH2

Tyr-Ala-Asp-Ala- le-Phe-Thr-Asn-

Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-

Leu-Ser-Ala-Arg-Lys-Leu-Leu-

Gln-Asp-lle-Met-Ser-Arg-Gln-Gln-

Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-

Ala-Arg-Ala-Arg-Leu-NH2

N

S

N NHO

O

.2HCl

NN

H3CO

HN

N

CH3


H0002 H8/ N-[2-(Methylamino)ethyl]-5- 5 mg

isoquinolinesulfonamide, Di-HCl Salt} 25 mgC12H15N3O2S.2HCl FW 338.25 [113276-94-1]A potent inhibitor of PKA and cAMP.

Jung CS Lee SJ Paik SS et al. Neuroscience Lett. 282 53-6 (2000).

Rosado E Schwartz Z Sylvia VL et al. Biochim Biophys Acta. 1590 1-15 (2002).

H0003 H89/ (N-[2-[P-Bromocinnamylamino]-ethyl)- 1 mg

5-isoquinolinesulfonmide) 5 mgC20H20BrN3O2S FW 446.36 [127243-85-0]Selective potent inhibitor of CAMP-dependent protein kinase (PKA).

Murol M Suzuki T. Cell Signal. 5 289 (1993).

H0100 HA Peptide 1 mgC53H67N9O17 FW 1102.18 [92000-76-5] 2 mg

5 mg

H0142 Haloperidol (See page 21 for more information) 5 gC21H23ClFNO2 FW 375.86 [52-86-8] 10 gA typical antipsychotic, that has been shown to alter GABA transporter 25 g expression in rats. It has also been shown to induce apoptosis of neurons in the striatum and substantia nigra of rat.Mitchell IJ Cooper AC Griffiths MR et al. Neuroscience. 109 89-99 (2002).

Zink M Schmitt A May B et al. Pharmacopsychiatry. 37 171-4 (2004).

H0169 Harringtonin 5 mgC28H37NO9 FW 531.59 [26833-85-2] 10 mgAlkaloid isolated from Cephalotaxus. Antitumor agent. 25 mgPower RG. Phytochemistry. 11 1467-1472 (1972).

H0207 HBV core protein (128-140) 0.5 mgC66H103N17O17 FW 1406.64 1 mg

2.5 mg

H1643 Helodermin 0.5 mgC176H283N 5O51 FW 3845.49 [89468-62-2] 1 mgA VIP/secretin-like peptide that was originally isolated from Gila monster venom. 2.5 mgBjartell A Persson P Absood A et al. Regul Pept. 26 27-34 (1989).

H1644 Helodormin 1 mgC176H285N 7O 9 FW 3843.47 [89468-62-2]

H1645 Helospectin I 1 mgC183H293N 7O59 FW 4095.66 [93438-37-0] 2 mg

5 mg

O

O

N

O

O

OH

OO

OHO

H-Thr-Pro-Pro-Ala-Tyr-Arg-Pro-

Pro-Asn-Ala-Pro-Ile-Leu-OH

H-His-Ser-Asp-Ala- le-Phe-Thr-

Glu-Glu-Tyr-Ser-Lys-Leu-Leu-

Ala-Lys-Leu-Ala-Leu-Gln-Lys-

Tyr-Leu-Ala-Ser- le-Leu-Gly-Ser-

Arg-Thr-Ser-Pro-Pro-Pro-NH2

H-His-Ser-Asp-Ala-Thr-Phe-Thr-

Ala-Glu-Tyr-Ser-Lys-Leu-Leu-Ala-

Lys-Leu-Ala-Leu-Gln-Lys-Tyr-Leu-

Glu-Ser-Ile-Leu-Gly-Ser-Ser-Thr-

Ser-Pro-Arg-Pro-Pro-Ser-Ser-OH

Glu Tyr S r Lys Leu eu Ala

H-Tyr-Pro-Tyr-Asp-Val-Pro-Asp-

Tyr-Ala-OH

His-Ser-Asp-Ala-lle-Phe-Thr-Gln-

Gln-Tyr-Ser-Lys-Leu-Leu-Ala-Lys-

Leu-Ala-Leu-Gln-Lys-Tyr-Leu-Ala-

Ser-lle-Leu-Gly-Ser-Arg-Thr-Ser-

Pro-Pro-Pro-NH2


H1646 Helospectin II 1 mgC180H288N 6O57 FW 4008.58 [93585-83-2] 2 mg

5 mg

H1648 Hemorphin-7 1 mgC 9H6 N12O11 FW 997.12 2 mg

5 mg

H1657 Heparin-Binding Peptide 0.5 mgC 7H7 N16O10 FW 1023.22 [125720-21-0] 1 mg

2.5 mg

H1658 Heparin Sodium 1 g[9041-08-1]Derived from intestinal mucosa. Anticogulant heparin enhances blood coagulation

and fibrinolysis during hemodialysis with prostacyclin.

Kandrotas RJ. Clin Pharmacokinet 22 359-74 (1992).

Hirsh J Heparin N. Engl J. Med. 324 1565-74 (1991).

H1661 Hepatitis B Virus core protein (128-140) 1 mgHBV Core protein (128-140)

C66H103N17O17 FW 1406.64

H1862 Heptaplatin 5 mgC11H20N2O6Pt FW 471.36 [146665-77-2] 10 mgA platinum derivative with anticancer activity against various cancer cell lines, 25 mgincluding cisplatin-resistant cancer cell lines.

Cancer Chemother Pharmacol 35 441 (1995).

H1660 2-n-Heptylfuran 10 gC11H18O FW 166.27 b.p. 96-970C/30mm [3777-71-7] 20 gInhibitor of BP-induced lung and forestomach tumorigenesis in mice.Lam LK et al. Nutr. Cancer. 17 19-26 (1992).

H1662 HER2/neu (654-662) GP2 1 mgC 2H77N9O11 FW 884.12 2 mg

5 mg

H1663 HER2/neu (869-877) 1 mgC 9H75N9O20 FW 1110.19 2 mg

5 mg

H1669 Herbimycin A 100 µgC30H 2N2O9 FW 574.66 [70563-58-5]Tyrosine kinase inhibitor cell permeable, inhibits platelet derived

growth factor induced phospholipase D activation.Satoh T et al. J. Biolchem. 267 2537 (1992).

H1672 Hesperetin 1 gC16H1 O6 FW 302.28 [520-33-2] 5 gThe aglycone of Hesperidin. 10 g

O

OOH

HO

OCH3

OH



Lys-Leu-Ala-Leu-Gln-Lys-Tyr-

Leu-Glu-Ser-Ile-Leu-Gly-Ser-Ser-

Thr-Ser-Pro-Arg-Pro-Pro-Ser-OH

H-Trp-Gln-Pro-Pro-Arg-Ala-Arg-

le-OH

lle-lle-Ser-Ala-Val-Val-Gly-

lle-Leu

Leu-Leu-Asp-Ile-Asp-Glu-Thr-

Glu-Tyr

Tyr-Pro-Trp-Thr-Gln-Arg-Phe

Thr-Pro-Pro-Ala-Tyr-Arg-Pro-Pro-

Asn-Ala-Pro-lle-Leu


H1673 Hesperidin 25 gC28H3 O15 FW 610.56 [520-26-3] 100 gA flavonoid which has been found to be a potent chemopreventive agent

in oral, colon, and urinary bladder carcinogenesis in animal models.

Tanaka T Makita H Ohnishi M et al. Cancer Res. 57 246-252 (1997)

Tanaka T Makita H Kawabata K et al. Carcinogenesis. 18 957-965 (1997).

Yang M Tanaka T Hirose Y et al. Int. J. Cancer. 73 719-724 (1997).

H1992 Hexaconazole 500 mgC1 H17Cl2N3O FW 314.21 [79983-71-4] 5 gFungicide, bactericide, wood preservative 25 gKumar PR Kanniappan M Mathuram LN et al. Res. J Pharmacol. 5 9-13 (2011).

H1794 Hexamethonium bromide hydrate 10 gC12H30Br2N2

.xH2O FW 362.20 [55-97-0] 25 gA nicotinic acetyl choline receptor antagonist. It induces apoptosis and inhibits 100 g the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation.

It is also effective in preventing organophosphate intoxication.

Vallablanca AC J appl Physiol. 84 2089-98 (1998).

Maneckjee R Minna JD. Cell Growth Differ. 5 1033-40 (1994).

Sanchez-Fortun S Sanz F Barahona MV. Arch Environ Contam Toxicol. 31 391-8 (1996).

H1892 Hexamethylene Bisacetamide 25 gC10H20N2O2 FW 200.28 [3073-59-4] 50 gPrototype of hybrid polar inducers of apoptosis of various transformed cells.Marks PA Richon VM Breslow R Rifkind RA. C R Acad Sci III 322 161-5 (1999).

H1893 Hexarelin 1 mgC 7H58N12O6 FW 887.0 [140703-51-1] 5 mgA growth hormone secretagogue that has been shown to inhibit apoptosis in 50 mg several models. It is suggested that the inhibitory activity could be explained

by its cardioprotective effect.

Pang JJ Xu RK Xu XB et al. Am J Physiol Heart Circ Physiol. 286 H1063-9 (2004).

Filigheddu N Fubini A Baldanzi G et al. Endocrine. 14 113-9 (2001).

H1894 Hexestrol 1 gC18H22O2 FW 270.37 [84-16-2] 5 gA carcinogenic synthetic estrogen that inhibits microtubule polymerization and the formation of ribbon structures. It is an inhibitor of lipid peroxidation.

Sato et al. J. Biochem. 101 1247-1252 (1987).

Wiseman H Halliwell B. FEBS Lett. 332 159-63 (1993).

Liehr JG Ballatore AM Dague BB. Chem Biol Interact. 55 157-76 (1985).

H1695 S-Hexylglutathione 100 mgC16H29N3O6S FW 391.50 [24425-56-7] 250 mgLigand useful for affinity chromatography of glutathione-S-transferase and 1 gglutathione peroxidase.

Kajihara-Kano H Hayakari M Satoh K et al. Biochem. J. 328 473-478 (1997).

H3272 His Tag 5 mgC36H 2N18O6 FW 822.85

H3273 Histatin 5 0.5 mgC133H195N51O33 FW 3036.36 [115966-68-2] 1 mg

2.5 mg

H3C NH

HN CH3

O

O

His-His-His-His-His-His

H-Asp-Ser-His-Ala-Lys-Arg-

His-His-Gly-Tyr-Lys-Arg-Lys-

Phe-His-Glu-Lys-His-His-Ser-

His-Arg-Gly-Tyr-OH

His-D-2-Me-Trp-Ala-Trp-D-Phe-

Lys-NH2


H3277 Histrelin Acetate Please inquire

C66H86N18O12 FW 1323 52 [76712-82-8]Histrelin acetate is a potent LHRH agonist. For the treatment of central precocious puberty.

H3274 HIV p17 Gag (77-85) 1 mgC H72N10O15 FW 981.1 2 mgInvolved in the replication cycle of the HIV virus. 5 mg

H3275 HIV Integrase Protein Inhibitor (1) 1 mgC 6H55N11O7S FW 906.1 2 mg

5 mg

H3276 HIV Protease Substrate 1 mgC33H59N11O10 FW 769.9

H3278 HIV RT (pol) A2.1 peptide 1 mgC 6H78N12O12 FW 991.21 2 mg

5 mg

HMG (Human Menopausal Gonadotropins) (See Menotropins)

H5748 DL-Homocysteine thiolactone hydrochloride 50 gC H7NOS.HCl FW 153.63 m.p. 201-2020C [6038-19-3] 100 gHomologue of the amino acid cysteine.

H5750 Homoharringtonin 1 mgC29H39NO9 FW 545.62 [26833-87-4] 5 mgHomoharringtonin is an alkaloid isolated from Cephalotaxus hainanensis. 10 mgFound to have antitumor activities.

Corbett TH Griswold DP Roberts BJ et al. Cancer. 40 2660-2680 (1977).

Powell RG Rogovin SP Smith CR. Ind. Eng. Chem. Prod. Res. Dev. 13 129-132 (1974).

H5654 Honokiol 10 mgC18H18O2 FW 266.33 [35354-74-6] 25 mgA phenolic compound isolated from Magnolia officinalis. It has many 100 mg interesting biological activities. Inhibits leukotriene synthesis, protects rat

heart mitochondria and liver from peroxidative injury, and has anxiolytic and antiarrhythmic

effects. Possesses antimicrobial and antifungal activity. Found to

induce apoptosis in human squamous lung cancer CH27 cells.

Yang SE Hsieh MT Tsai TH Hsu SL. Biochem Pharm. 63 1641-1651 (2002).

Hamasaki Y Muro E Miyanji S et al. Int. Arch Allergy Immun. 110 278-281 (1996).

Lo YC Teng CM Chen CF Et al. Biochem Pharm. 47 549-553 (1994).

Kuribara H Stavinoha WB Maruyama Y. J Pharm Pharm. 50 819-826 (1998).

H2876 H-Trp-Gly-OH 1 mg C13H13N3O2 FW 261.28

H8048 Human Follicular Gonadotropin Releasing Peptide 1 mg(Hf-GRP)

C68H9 N22O27 FW 1651.6

Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-

Leu-Arg-Pro-NHEt

His-Cys-Lys-Phe-Trp-Trp

Ser-Leu-Tyr-Asn-Thr-Val-Ala-

Thr-Leu

Ac-Ala-Arg-Val-Leu-Ala-Glu-

Ala-NH2

H- le-Leu-Lys-Glu-Pro-Val-His-

Gly-Val-OH

Trp-Gly

Thr-Asp-Thr-Ser-His-His-Asp-

Gln-Asp-His-Pro-Thr-Phe-Asn

Al P Gl P S

SO

NH2.HCl

N

O

O

O

O

O

OH

OH

H

O

O


H2980 Humanin, human 0.5 mgC119H20 N3 O32S2 FW 2687.28 [330936-69-1] 1 mgInhibits neuronal cell death caused by Swedish mutant (K595N/M596L-APP ). 2.5 mgHashimoto Y Ito Y Niikura T et al. Biochem Biophys Res Commun. 283 460-468 (2001).

H8162 Huperzine A (See page 18 for more information) 1 mgC15H18N2O FW 242 32 [102518-79-6] 5 mgNatural product from Lycopodium serratum Thunb. It is a potent acetylcholinesterase inhibitor

with neuroprotective properties that are of interest in the treatment of Alzheimer's disease. It hasbeen shown to inhibit staurosporine-induced apoptosis.Zhang HY Tang XC. Neurosci Lett. 340 91-4 (2003).

Wang LS Zhou J Shao XM et al. Zhonghua Er Ke Za Zhi. 41 42-5 (2003).

Zhang HY Yan H Tang XC. Neuosci Lett. 360 21-4 (2004).

H9801 Hyaluronic Acid Sodium salt 100 mgFrom Streptococcus 500 mg(C1 H20NO11Na)n FW 1.65 [9067-32-7] 1 gHyaluronic acid is a major non-protein glycosnaine glycan component of

extracellular matrix in mammalian cells.Meyer K Palmer JW. J. Biol. Chem. 107 629 (1934).

H9614 Hydrochlorothiazide 5 gC7H8ClN3O S2 FW 297.74 [58-93-5] 25 gA thiazide diuretic commonly used as an antihypertensive.

Duarte JD Cooper-DeHoff RM. Expert Rev. Cardiovasc. Ter. 8 793-802 (2010).

H9611 Hydrocortisone 5 gC21H30O5 FW 362.46 [50-23-7] 10 gAn anti-inflammatory steroid, found to increase apoptotic events when used in 25 g combination with mifepristine in human LNcap prostate cancer cells. Inhibits

angiogenesis by abolishing VEGF expression. Known to inhibit superoxide generation.

El Etreby MF Liang Y Lewis RW. Prostate. 43 31-42 (2000).

Nauck M Karakiulakis G Perruchoud AP et al. Eur J Pharmacol. 341 309-15 (1998).

Okada Y Okada M. J Nutr Sci Vitaminol (Tokyo). 46 1-6 (2000).

H9612 Hydrocortisone 21-acetate 1 gC23H32O6 FW 404.50 [50-03-3] 5 gA corticosteroid with anti-inflammatory properties. It may stimulate superoxide 10 gdismutase production and may release antioxidants.Gavan N Maibach H. Skin Pharmacol. 10 309-13 (1997).

Michniak BB Chapman JM Seyda KL. J Pharm Sci. 82 214-9 (1993).

H9618 Hydroquinone 50 gC6H6O2 FW 110.11 [123-31-9]Topical hydroquinone is used in the treatment of a number of skin conditions. Found to reduce

the viable cell number of oral tumor cell.

Ozluer SM Muir J Australas J. Dermatol. 4 255-6 (2000).

Terasaka H Takayama F Satoh K Fujisawa S Sakagami H. Anticancer Res. 20 3357-62 (2000).

H9620 7-Hydroxyaristolochic acid A 1 mgC17H11NO8 FW 357-27 [475-80-9] 5 mgSee aristolochic acid A. 10 mg

OH

OH

NO2

OHO

O

OCH3

O

OH

O O

COONa

OH

OH

O

CH2OH

HN

HO

O OH

CH2OH

HO

O O

COONa

OH

OH

HO

O

CH3

O

HN CH3

On 1

Met-Ala-Pro-Arg-Gly-Phe-Ser-

Cys-Leu-Leu-Leu-Leu-Thr-Ser-

Glu-Ile-Asp-Leu-Pro-Val-Lys-

Arg-Arg-Ala


20-Hydroxyecdysone (See Ecdysterone)

H9615 17α-Hydroxyprogesterone Caproate 1 gC27H 0O FW 428.60 [630-56-8] 5 gAn antiestrogen used to treat advanced endometrial cancer and breast cancer. 10 gReifenstein EC Cancer. 27 485-502 (1971).

Pasqualini JR Paris J Sitruk-Ware R et al. J Steroid Biochem Mol Biol. 65 225-35 (1998).

H9718 2-Hydroxy-flutamide 10 mgC11H11F3N2O FW 292.21 [52806-53-8] 25 mgMetabolite of flutamide found to inhibit the proliferation of estradiol-induced 100 mg growth of MCF-7 breast cancer cells. Shet MS McPhaul M Fisher CW et al. Drug Metab Dispos. 25 1298-303 (1997).

Di Monaco M Brignardello E Leonardi L et al. J Cancer Res Clin Oncol. 121 710-4 (1995).

H9613 N-(4-Hydroxyphenyl) retinamide 1 mgFenretinide, 4-HPR 5 mgC26H33NO2 FW 391.55 m.p. 173-1750C [65646-68-6] 10 mgA synthetic analog of vitamin A without the observed liver toxicity. Cancer

chemopreventive agent. Induces apoptosis in human cancer cell lines.Moon RC Thompson HJ Becci PJ et al. Cancer Res. 39 1339-1346 (1979).

Kalemkerian GP Slusher R Ramalingam S. J Natl Cancer Inst. 87 1674-80 (1995).

H9711 (Z)-4-Hydroxytamoxifen (See page 10 for more info) 5 mg C26H29NO2 FW 387.51 [68047-06-3] 10 mgAn active metabolite of (Z)-tamoxifen which exhibits higher potency as 25 mgestrogen agonist. It binds to estrogen receptors with 8-fold higher affinity than tamoxifen.

Kupfer D et al Cancer Res. 54 3140 (1994).

Lubczyk V Bachmann H Gust R J. Med. Chem. 45 5358 (2002).

H9712 (E)-4-Hydroxytamoxifen (See page 10 for more info) 5 mg C26H29NO2 FW 387 51 [174592-47-3] 10 mgLess active isomer of (Z)-4-hydroxytamoxifen. 25 mgRobertsonDW KatzenellenbogenJA LongDJ et al. J. Steroid Boichem. 16 1 (1982).

H9716 (E, Z)-4-Hydroxytamoxifen (See page 10 for more info) 5 mg C26H29NO2 FW 387 51 [68392-35-8] 10 mgMixture of cis- and trans-isomers of 4-hydroxytamoxifen. 25 mg

H9714 5-Hydroxy-L-tryptophan 250 mgL-5-HTP 1 gC11H12N2O3 FW 220.22 [4350-09-8] 5 g

25 g

3-Hydroxytyrosol (See 3,4-Dihydroxyphenyl Ethanol)

H9715 Hydroxyurea 5 g

CH N2O2 FW 76.06 [127-07-1] 10 gAnticancer agent. 50 gArgiris A Haraf DJ Kies MS Vokes EE. Oncologist. 8 350-60 (2003).

Halsey C Roberts IA. Haematol.121 200 (2003).

CF3

NO2HN

O

HO

NH

O

OH

HO

NH

NH2

O

O

OH

NH3C

CH3

CH3

O

OH

CH3

NH3C

CH3


H9814 25-Hydroxyvitamin D2 1 mgC28H O2 FW 412.65 [21343-40-8] 5 mgBiologically active metabolite of vitamin D2 which is more active in curing rickets than its parent. Morzycki JW Schnoes HK DeLuca HF. J. Org. Chem. 49 2148-2151 (1984).Schnoes H. K. DeLuca H. F. and Ikekawa N. J. Biol. Chem. 262 14164-14171 (1987).

H9815 25-Hydroxyvitamin D3 1 mgC27H O2 FW 400.64 [19356-17-3] 5 mgThe major circulating metabolite of vitamin D3. It is produced in the liver and is the

best indicator of the body's vitamin D stores. Blunt JW Deluca HF. Biochem. 8 671-675 (1969).DeLuca HF Schnoes HK. Ann Rev. Biochem. 45 631-636 (1976).

H9717 Hydroxyzine Dihydrochloride 5 gC21H27ClN2O2

.2HCl FW 447 83 [2192-20-3] 10 gA piperazine compound. It is a heterocyclic histamine-1 receptor antagonist that is also

known to block mast cells.Gerber JG Skoglund ML Nies AS. Agents Actions. 12 259-62 (1982).

Dimitriadou V Pang X Theoharides TC. Int J Immunopharmacol. 22 673-84 (2000).

H9816 2-Hydroxy Estradiol 1 mgC18H2 O3 FW 288.38 [362-05-0] 5 mg2-hydroxy Estradiol (2-HE2) is a cytochrome P450 metabolite of estradiol with 10 mglow affinity for estrogen receptors.

Becker C.M. Rohwer N. Funakoshi T. et al. Am J Pathol 172(2) 534-544 (2008).

Hyoscine Butyl BromideScopolamine N-Butyl Bromide

H9759 Hypaconitine (See page 19 for more information) 10 mgC33H 5NO10 FW 615.71 [6900-87-4] 25 mgA diterpene alkaloid isolated from Aconiti Carmichaeli Praeparata that is a 100 mg neuromuscular blocker.

Shim SH Kim JS Kang SS et al. Arch Pharm Res. 26 709-15 (2003).

Muroi M Kimura I Kimura M. Neuropharmacology. 29 567-72 (1990).

H9861 Hypericin 1 mgC30H16O8 FW 504.44 [548-04-9] 5 mgNatural product from Hypericum perforatum (St. John's wort). It is an inhibitor of PKC.

It has antiviral and anticancer activities and induces photosensitized apoptosis.

Couldwell WT Gopalakrishna R Hinton DR et al. Neurosurgery. 35 705-9 (1994).

Weller M Trepel M Grimmel C et al. Neurol Res. 19 459-70 (1997).

Lavie G Kaplinsky C Toren A et al. Br J Cancer. 79 423-32 (1999).

H9662 Hypocrellin B 10 mgC30H2 O9 FW 528.51 [123940-54-5 25 mgThe hypocrellins are pigments isolated from the fungi Hypocrella bambusae and 100 mgShiraia bambusicola. They are used as photosensitizers for photodynamic therapy of cancer.

Yuying H. Jingyi A. Lijin J. Free Radic. Biol. Med. 26 1146-1157 (1999).

H9763 Hypoxanthine 5 gC5H N O FW 136.11 [68-94-0] 25 gA marker for energy perturbation in hypoxia/ischemia and uric acid production. 100 gMarklund N Ostman B Nalmo L et al. Acta Neurochir (Wien). 142 1135-41 (2000).

OOH OH

OH

OH

OHOOH

H3C

H3C

OH O

OOH

H3CO

H3CO

OCH3

CH3

COCH3

OCH3


I0502 Ibandronate Monosodium Monohydrate 50 mgC9H22NO7P2

.Na.H2O FW 359.21 [138926-19-9] 100 mgA third generation bisphosphonate used as bone resorptive inhibitor. Found to enhance

the antitumor activity of taxol and docetaxol in bone metastasis.Dooley M Balfour JA. Drugs. 57 101-8 (1999).

Magnetto S Boissier S Delmas PD Clezardin P. Int J Cancer. 83 263-9 (1999).

I0416 Iberin 10 mgC5H9NOS2 FW 163.26 [505-44-2] 25 mgHomolog of sulforaphane. 50 mg

100 mg

I0418 Iberverin 25 mgC5H9NS2 FW 147.26 [505-79-3] 50 mgMay induce phase II detoxification and protect against chemical carcinogenesis. 100 mgMunday R.; Munday C. J. Agric. Food Chem. 52 1867 1871 (2004). 500 mg

I0480 Ibudilast 10 mgC1 H18N2O FW 230.31 [50847-11-5] 25 mgAn anti-inflammatory drug which acts as a phosphodiesterase inhibitor includig 100 mgthe POE-4. Know to have bronchodialator, vasodialator and neuroprotective effects.

Ledeboer A. Expert Opinion on Investigational Drugs (2007) 16(7) 935-950.

I0481 Ibuprofen (See page 25 for more information) 1 gC13H18O2 FW 206.28 [15687-27-1] 5 gNon-steroidal anti-inflammatory agent. It has undergone clinical 10 gtrials as a chemopreventive agent.

Kelloff GJ Boone CW Crowell JA et al. Cancer Epidemiol. Biomarkers Prev. 3 85-98 (1994).

I0482 S(+) Ibuprofen 1 gFW 206.28 [51146-56-6] 5 gThe optically active form of Ibuprofen. 25 g

I0901 Icariin (See page 15 for more information) 100 mgC33H 0O15 FW 676.66 [489-32-7] 500 mgA flavonol glycoside isolated from Epimedium that has antihepatotoxic activity. It was found 1 gto induce differentiatioin of HL-60 cells.

Lee MK Choi YJ Sung SH. Planta Medica 61 523-526 (1995).

Zhao Y Cui Z Zhang L. Chinese J Oncol.19 53-55 (1997).

I1400 Idarubicin Hydrochloride 1 mgC26H27NO9

.HCl FW 533.96 [57852-57-0] 5 mgIt is a derivative of daunorubicin that has high antitumor activity against leukemia

and breast cancer. It induces apoptosis.

Ganzina F Pacciarini MA Di Pietro N. Invest New Drugs. 4 85-105 (1986).

Tsuruo T Oh-Hara T Sudo Y Naito M. Anticancer Res. 13 357-61 (1993).

Belaud-Rotureau MA Durrieu F Labroille G et al. Leukemia. 14 1266-75 (2000).

O

O

OH

OH

COCH3

OH

O

OH3C

HO

NH2.HCl

O

O

O

O

O

OH

O

OH

OH

OH

OH

O

OHOH

OH

H3C

S N

C

S

NN

OH3C

H3C

H3C

H3C


I1418 Idebenone 10 mgC18H28O5 FW 324.41 [58186-27-9] 25 mgIdebenone, a coenzyme Q analogue, is an antioxidant that prevents stroke and 100 mg renal vascular lesions in hypertensive rats. Its protective effects involve the

redox cycling between its hydroquinone and quinone forms.

Mordente A Martorana GE Minotti G Giardina B. Chem Res Toxicol. 11 54-63 (1998).

Nagaoka A Shino A Kakihana M Iwatsuka H. Jpn J Pharmacol. 36 291-9 (1984).

I1257 Idoxuridine 500 mg5-Iodo-2 -deoxyuridine 1 gC9H11IN2O5 FW 354.10 m.p. 164-1660C (dec.) [54-42-2]A cytotoxic, anti-viral thymidine analog.

Pressacco J Hedley DW Erlichman C. Cancer Res. 54 3772-3778 (1994).

I2056 Ifosfamide 25 mgC7H15Cl2N2O2P FW 261.09 [3778-73-2] 50 mgCytostatic Agent

Ritter S Schroder HJ. Medizinische Welt. 28 1395-1400 (1977).

Zalupski M Baker LH. J Natl Cancer Inst. 80 556-566 (1988).

I4000 Ikarugamycin 0.5 mgC29H 0N2O FW 480.64 [36531-78-9] 1 mgAn antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in 5 mg macrophage. Shown to be an efficient inhibitor of clathrin-coated pits-dependent endocytosis.

Jomon K Kuroda Y Ajisaka M Sakai H. J Antibiot (Tokyo). 25 271-80 (1972).

Hasumi K Shinohara C Naganuma S Endo A. Eur J Biochem. 205 841-6 (1992).

Luo T Fredericksen BL Hasumi K et al. I Virol. 75 2488-92 (2001).

I4659 Iloperidone 100 mgC2 H27FN2O FW 426.48 [133454-47-4] 250 mgIloperidone, a D2/5-HT2 antagonist is used to treat the symptoms of schizophrenia. 1 gStrupczewski JT Bordeau KJ Chiang Y et al J Med Chem 38 1119-1131 (1995).

Szczepanik AM Brougham LR Roehr JE et al J Pharmacol Exp Ther. 278 913-920 (1996).

I4802 Imatinib mesylate (See page 24 for more information) 25 mgC29H31N7O. CH O3S FW 589.72 [220127-57-1] 100 mgA tyrosine kinase inhibitor that has been used to great success in treating chronic 500 mgmyeloid leukemia.

Scheinfeld N. J Drugs Dermatol. 5(2) 117-22 (2006)

I5072 Imazalil 5 gC1 H1 Cl N2O FW 297.18 [35554-44-0] 10 gA pesticide with carcinogenic potential. 100gSmilanick J. Postharvest Biology and Technology (2008) 47(2) 226-238

I4934 Imipenem Monohydrate 25 mg C12H17N3O S.H2O FW 317.36 [74431-23-5] 100 mgImipenem is a potent third generation cephalosporin often used as a post 500 mg operative anti-biotic. It has recently shown promise in fighting increasingly more

resistant strains of staphylococcus aureus.Morimoto Y Sugiura T Tatebayashi S Kirita T. Spec Care Dentist. 26 209-13 (2006).

HN

O

NH

HO

OO


I5034 Imiquimod 100 mgC1 H16N FW 240.30 [99011-02-6] 500 mgAn immune response modifier that induces α-interferon in numerous species 1 gincluding human. It inhibits colon and lung tumors in mice and has antiviral 5 gactivity against HSV-2 infection. Its antitumor activity is related to the induction of apoptosis.Sidky YA Borden EC Weeks CE et al. Cancer Res. 52 3528-33 (1992).

Bernstein DI Harrison CJ. Antimicrob Agents Chemotgher. 33 1511-5 (1989).

Gibson SJ Lindh JM Riter TR et al. Cell Immunol. 218 74-86 (2002).

Schon M Bong AB Drewniok C et al. J Natl Cancer Inst. 95 1138-49 (2003).

I4961 Imperatorin 5 mgC16H1 O FW 270.28 [482-44-0] 25 mgImperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 100 mgresearch. It inhibits cyclin D1 expression and stops the cell cycle at G1.

Pae H.O. et al. Pharmacol. Toxicol. 91 40-48 (2002).

Sancho R. et al. J. Biol. Chem. 279 37349-37359 (2004).

I4962 Isoimperatorin 5 mgC16H1 O FW 270.28 [482-45-1] 25 mgIsoimperatorin is an anti-inflammatory agent, that also has an effect on proliferation, 100 mgisolated from the dried roots of Angelicae dahuricae.Pokharel Y.R. et al. Carcinogenesis. 27 2483-2490 (2006).

Incadronate Disodium(See Disodium Cycloheptylaminomethylene Diphosphonate)

I5414 Indapamide 250 mgC6H16ClN3O3S FW 365.84 [26807-65-8] 1 gAn antihypertensive agent that reduces intracellular calcium levels, maintains 5 g magnesium ion but reduces phosphate ions involved in arterial rigidity and many other functions.Campbell DB Brackman F. Am J Cardiol. 65 11H-27H (1990).

I5313 Indinavir Sulfate 1 gC36H 9N5O8S FW 711.87 [157810-81-6] 5 gAntiviral. Member of the novel hydroxyaminopentane amide class of HIV-1 protease 25 ginhibitors.Balani S.K. et al. Drug Metab. Dispos. 23 266 (1995)

I5213 Indole-3-carbinol (See page 11 for more information) 5 g3-Indolemethanol 25 gC9H9NO FW 147.18 m.p. 96-980C [700-06-1]A component of cruciferus vegetables. Found to be effective against chemically induced carcinogenesis.Grubbs CJ Steele VE Casebolt T et al. Anticancer Res. 15 709-716 (1995).

I5215 Indolicidin 0.5 mgC100H132N26O13 FW 1906.33 [140896-21-5] 1 mgAn antimicrobial peptide containing multiple tryptophan residues. 2.5 mgSelsted ME Novotny MJ Morris WL et al. J Biol Chem. 267 4292-4295 (1992).

I5315 Indomethacin 5 gC19H16ClNO FW 357.79 [53-86-1] 10 gA non-steroidal anti-inflammatory agent which inhibits the activity of 25 gcyclooxygenase and the induction of ornithine decarboxylase. It has cancer 100 gchemopreventive activity and induces apoptosis.Verma AK Ashendel CL Boutwell RK. Cancer Res. 40 308-315 (1980).

Grubbs CJ Juliana MM Eto I et al Anticancer Res. 13 33-6 (1993).

Tanaka T Suzui M Kojima T et al. Cancer Detection Prev. 19 418-25 (1995).

Zhou XM Wong BC Fan XM et al. Carcinogenesis. 22 1393-7 (2001).

N

CH3

CH2CO2H

CH3O

C

ClO

N

CH3

HNS

NH2

Cl

OOO

H- le-Leu-Pro-Trp-Lys-Trp-Pro-

Trp-Trp-Pro-Trp-Arg-Arg-NH2


I5354 Iniparib (See page 30 for more information) 5 mgC7H5IN2O3 FW 292 03 [160003-66-7]An irreversible inhibitor of PARP-1.

J. O Shaughnessy C. Osborne J. E.Pippen et al. New England Journal of Medicine 364 (3) 205–214 (2011).

I5357 Inositol 100 gC6H12O6 FW 180.16 [6917-35-7] 500 gIs an essentially non toxic compound largely formed by the dephosphorylation of inositol

hexaphosphate (IP6, Phytate) within the gastrointestinal tract in humans and animals. It

reduces chemically induced lung tumor formation in experimental animals when administered

after carcinogen treatment. It also suppresses liver carcinogenesis in male C3H/He mice.

Wattenberg LW Anticancer Res. 19 3659-61 (1999).

Hecht SS Kenney PM Wang M et al. Cancer Lett.137 123-30 (1999).

Nishino H Murakoshi M et al. Anticancer Res. 19 3663-64 (1999).

Inositol hexaphosphate (See Phytic acid)

I5476 Interleukin-6 Receptor (partial) 0.5 mgC51H85N13O21 FW 1216 32 1 mg

2.5 mg

I5830 Iohexol 1 gC19H26I3N3O9 FW 821.14 [66108-95-0] 5 gA non-ionic contrast agent. 25 gWieslander JB Stjernquist U. Acta Radiol Suppl. 370 73-7 (1987).

I5752 Ionomycin free acid 1 mgC 1H72O9 FW 709.00 [56092-81-0] 5 mgIt is an effective Ca++ ionophore, induces apoptotic degeneration of

embryonic cortical neurons.Elzi D.J. et al. Am. J. Physiol. Cell Physiol. 281 C350-C360 (2001).

I5753 Ionomycin (Calcium Salt) 1 mgC 1H79O9

2-Ca FW 747.1 [56092-82-1] 5 mgA calcium ionophore known for its antipoliferative effects. It inhibits growth of human bladder

cancer cells with alteration of Bcl-2 and Bax expression levels. An apoptosis inducer.

Miyake H Hara I Yamanaka K Arakawa S Kamidono S. J Urology. 162 916-21 (1999).

Aagaard-Tillery KM Jelinek DF. J Immunology. 155 3297-107 (1995).

I6068 Ipriflavone 1 gC18H16O3 FW 280.32 [35212-22-7] 5 gA synthetic phytoestrogen used as preventative in bone loss. Shown to enhance 10 gcalcium transport.

Arjmandi BN Khalil DA Hollis BW. Calc Tiss Int. 67 225-9 (2000).

Glazier MG Bowman MA. Arch Int Med. 161 1161-72 (2001).

I6804 Irbesartan 1 gC25H28N6O FW 428.53 [138402-11-6] 5 gAngiotensin II type 1 receptor antagonist. 25 gMerck Index 13rd ed. Merk & Co. Inc. Whithouse Station NJ.349 (2001).

O

O

OCH

H3C

H3C

O

CH3

CH3

H

H3

CH3 H3

OH

H

H

H3

H3C

O

CH3 CH3 CH3

H

Ca

II

I

NHO

O

OHN OH

HN OH

OH

OH

OH3C

OH

H-Thr-Ser-Leu-Pro-Val-Gln-

Asp-Ser-Ser-Ser-Val-Pro-OH


I6932 Irinotecan 5 mgC33H38N O6 FW 586.68 [97682-44-5] 10 mgAn inhibitor of the nuclear enzyme topoisomerase I. 25 mgKellner U Rudolph P Parwaresch R. Onkologie. 23 424-430 (2000). 100 mg

I6933 Irinotecan HCl trihydrate 5 mgC33H38N O6

.HCl.3H2O FW 677.19 [136572-09-3] 10 mgA member of the camptothecin drug family, and an inhibitor of the nuclear 25 mgenzyme topoisomerase I which is involved in cellular DNA replication and transcription. 100 mg During replication Topoisomerase I mediates the relaxation of super coiled DNA, and its

inhibition results in breakage replication of the DNA chain and likely induces apoptosis.

Irinotecan is therefore an attractive target for anticancer drug development. Currently it is used for the treatment of small cell lung cancer and advanced colorectal cancer.

Kellner U Rudolph P Parwaresch R. Onkologie. 23 424-430 (2000).

Kalemkerian GP Worden FP. Expert Opin Investing Drugs. 9 565-79 (2000).

Saltz LB. Curr Oncol Rep. 1 155-160 (1999).

I7074 Irsogladine Maleate 100 mgC9H7Cl2N5

.C H O FW 372.17 [84504-69-8] 500 mgAn anti-gastric ulcer agent that facilitates gap-junctional intercellular 1 gcommunication through M1 muscarininc acetylcholine receptor binding. It is a

potent inhibitor of angiogenesis and protects MNNG-induced gastric carcinogenesis in rats.

Ueda F, Ban K, Ishima T. J Pharmacol Exp Ther. 274 815-9 (1995).

Sato Y, Morimoto A, Kiue A et al. FEBS Lett. 322 155-8 (1993).

Ren CJ, Ueda F, Roses DF et al. J Surg Res. 77 126-31 (1998).

Sugie S, Okamoto K, Watanabe T et al. Toxicology. 166 53-61 (2001).

I7302 Isatin 100 gIndole-2,3-dione 500 gC8H5NO2 FW 147.13 [91-56-5]An endogenous monoamine oxidase inhibitor that is involved in stress and anxiety. It is

an inhibitor of alkaline phosphatase, nitric oxide (NO)-stimulated soluble guanylate

cyclase, and other enzymes.

Hamaue N. Yakugaku Zasshi. 120 352-62 (2000).

Singh B Kumar P Bansal RC et al. Enzyme. 23 22-8 (1978).

Medvedev A Bussygyna O Pyatakova N et al. Biochem Pharmacol. 63 763-6 (2002).

I7256 Isobavachalcone 1 mgC20H20O FW 324.37 [20784-50-3] 5 mgA natural product that is present in the seed of Psoralea corylifolia. It has antiplatelet

activity by inhibiting the arachdonic acid-induced paltelet aggregation. Its anitproliferative

activity is attributed to the inhibition of Akt1 kinase whch induces apoptosis.

Tsai W.J. Hsin WC Chen CC J. Nat. Prod. 59 671-2 (1996).

Nishimura R Tabata K Arakawa M et al. Biol. Pharm. Bull. 30(10) 1878—1883 (2007).

Jing H Zhou X Dong X et al Cancer Lett. 294 167-177(2010).

I7341 Isoniazid 5 gC6H7N3O FW 137.14 [54-85-3] 50 gA front-line antituberculosis agent. It generates nitric oxide when activated by 100 g KatG, and has been shown to be a strong inhibitor of DPH metabolism.

Timmins GS Master S Rusnak F et al. J Bacteriol. 186 5427-31 (2004).

Kutt H. Epilepsia. 16 393-402 (1975).


I7356 Isopropyl Thiogalactoside 1 gC9H18O5S FW 238.30 [367-93-1] 5 gAn inhibitor of lac repressor, can modulate demethylation of the lac operator 10 g DNA sites.

Iping GL Thomas JT Qinglin Ou Chih-Lin Hsieh. MCB. 20 2343-2349 (2000).

I7259 Isoproterenol Hydrochloride 5 g Isoprenaline HCl 25 gC11H17NO3

.HCl FW 247.72 [51-30-9] 100 gA β-adrenergic agonist.

I7357 Isorhamnetin 1 mgC16H12O7 FW 316.26 m.p. 3050C (dec.) [480-19-3] 5 mgA metabolite of quercetin. One of many flavonoids found in red wine. It inhibits

xanthine oxidase, which is implicated in oxidative damage to cells. Has anti-tumor promoting activity.

Burns J. Gardner PT O'Neil J et al. J. Agric. Food Chem. 48 220-230 (2000).

Nagao A Seki M Kobayashi H. Biosci. Biotechnol. Biochem. 63 1787-1790 (1999).

Ito H Miyake M Nishitani E et al. Cancer Lett. 143 5-13 (1999)

Isoquinolinesulfonyl-2-methylpiperazine (See H7)

I7360 Isosorbide Mononitrate 5 gC6H9NO6 FW 191.14 [16051-77-7] 10 gA coronary vasodilator that does not require hepatic biotransformation. 25 gHayes PC Westaby D Williams R. Gut. 29 752-5 (1988).

I7746 1-Isothiocyanato-7-(methylsulfenyl)-heptane 10 mg7-Methylsulfenylheptyl isothiocyanate 25 mgC9H17NS2 FW 203.37 50 mgAn analog of erucin.

I7447 1-Isothiocyanato-6-(methylsulfenyl)-hexane 25 mg6-Methylsulfenylhexyl isothiocyanate 50 mgC8H15NS2 FW 189.34 100 mgAn analog of erucin.

I7558 1-Isothiocyanato-9-(methylsulfenyl)-nonane 25 mg9-Methylsulfenylnonyl isothiocyanate 50 mgC11H21NS2 FW 234.42 100 mgA synthetic analog of erucin.

I7359 1-Isothiocyanato-8-(methylsulfenyl)-octane 25 mg8-Methylsulfenyloctyl isothiocyanate 50 mgC10H19NS2 FW 217.40 100 mgAn analog of Erucin.

I7456 1-Isothiocyanato-7-(methylsulfinyl)-heptane 10 mg7-Methylsulfinylheptyl isothiocyanate 25 mgC9H17NOS2 FW 219 37 50 mgA synthetic compound that is present in watercress. 100 mgFound to be a potent inducer of phase II enzymesPeter R Kathy F Wary W Richard M. Carcinogenesis. 21 1983-1988 (2000).

O

OH

OHHO

HO

S

S (CH2)6 NCS

S (CH2)7 NCS

S (CH2)8 NCS

S (CH2)9 NCS

O

OH

OH

OCH3

OOH

HO

HO

HO

HN CH3

OH

CH3HCl


I7457 1-Isothiocyanato-6-(methylsulfinyl)-hexane 25 mgC8H15NOS2 FW 205.34 50 mg6-Methylsulfinylhexyl isothiocyante is a synthetic analogue of sulforaphane. 100 mg

I7458 1-Isothiocyanato-9-(methylsulfinyl)-nonane 25 mg9-Methylsulfinylnonnyl isothiocyanate 50 mgC11H21NOS2 FW 247.42 100 mgA synthetic analouge of well known phase II inducer sulforaphane.

I7459 1-Isothiocyanato-8-(methylsulfinyl)-octane 25 mg8-Methylsulfinyloctyl isothiocyanate 50 mgC10H19NOS2 FW 233.40 100 mgA synthetic compound that is present in watercress. Found

to be a potent inducer of Phase II enzymes.

Peter R Kathy F Gary W Richard M. Carcinogenesis. 21 1983-1988 (2000).

I7556 1-Isothiocyanato-7-(methylsulfonyl)-heptane 10 mg7-Methylsulfonylheptyl isothiocyanate 25 mgC9H17NO2S2 FW 235.37 50 mgAn analog of erysolin.

I7557 1-Isothiocyanato-6-(methylsulfonyl)-hexane 25 mg6-Methylsulfonylhexyl isothiocyanate 50 mgC8H15NO2S2 FW 221.34 100 mgAn analog of erysolin.

I7658 1-Isothicyanato-9-(methylsulfonyl)-nonane 25 mg9-Methylsulfonylnonyl isothiocyanate 50 mgC11H21NO2S2 FW 263.42 100 mgA synthetic analog of erysolin.

I7659 1-Isothicyanato-8-(methylsulfonyl)-octane 25 mg8-Methylsulfonyloctyl isothiocyanate 50 mgC10H19NO2S2 FW 249.40 100 mgAn analog of Erysolin.

Isotretinoin (See 13-cis-retinoic acid)

I7757 Itopride Hydrochloride (See page 21 for more info) 1 gC20H26N2O .HCl FW 394.88 [122892-31-3] 5 gA gastroprokinetic benzamide derviative that inhibits acetylcholinesterase 25 g reversibly.

Iwanaga Y Kimura T Miyashita N et al. Jpn J Pharmacol. 66 317-22 (1994).

I7870 Itraconazole (See page 16 for more information) 50 mgC35H38Cl2N8O FW 705.63 [84625-61-6] 100 mgA triazole antifungal agent. 250 mgBailey EM Krakovsky DJ Rybak MJ. Pharmacother. 10 146-53 (1990). 1 g

N NN

N

OCH2

HCH3CH2

CH3

O

H2

N

N

N

H

Cl

l

NH

O

N

CH3

H3CO

H3CO

O

CH3

O

H


I8618 Ivermectin (See page 21 for more information) 1 gB1a C 8H7 O1 FW 875.09 5 gB1b C 7H72O1 FW 861.06An anthelmintic found to be a competitive inhibitor of specific [3H]-GABA binding site in

nematodes. It activates the glycine receptor chloride channel.

Ros-Moreno RM Moreno-Guzman MJ Jimenez-Gonzalez A et al. Parasitol Res. 85 320-3 (1999).

Shan Q Haddrill JL Lynch JW. J Biol Chem. 276 12556-64 (2001).

K0021 K252A (See page 23 for more information) 100 µg C27H21N3O5 FW 467.48 [99533-80-9] 1 mgA potent protein kinase inhibitor that has shown promise fighting Met-driven proliferation

of gastric carcinoma cells.

Alessandro M Silvia M Paolo A Emma T Carola P Oncogene 21(32) 4885-4893 (2002).

Tapley P Lamballe F Barbacid M. Oncogene. 7(2) 371-81 (1992).

K0022 K252B (See page 23 for more information) 100 µg C26H16N3O5 FW 453.13 [99570-78-2] 1 mgAn ectoprotein kinase inhibitor that could have profound implications on the

treatment of prostate cancer.

Ellen M-C Kita T Shih W Dipaola R Chin K Clinical Cancer Research. 6 2309-2317 (2000).

Teshima et. al. Journal of immunology 159(2) 964-969 (1997).

K0023 K252C (See page 23 for more information) 1 mg C20H13N3O FW 311.34 [85753-43-1] 5 mgK252c inhibits protein kinase C.

Fabre S Prudhomme M Rapp M. Bioorg Med Chem. Sep;1(3) 193-6 (1993)

K7600 KT5720 (See page 23 for more information) 100 µg C32H31N3O5 FW 537.23 [108068-98-0] 1 mgA Protein Kinase a inhibitor that has been shown to reduce enzyme activity in

INF- alpha thereby creating a potential pathway to treat tumors.

Naviglio et. al. J Interferon Cytokine Res. 27(2) 1 (2007)

K7602 KT5823 (See page 23 for more information) 100 µg C29H25N3O5 FW 495.50 [126643-37-6] 1 mgA K252 derivitive.

K0117 Kaempferol, 95 % 1 mgC15H10O6 FW 286.24 MP: 276-8 oC [520-18-3] 5 mgKaempferol is a flavonoid present in various natural sources including red wines 10 mg and the leaves of gingko biloba. Kaempferol was found to inhibit COX-2 expression in colon cancer cells. It is cytotoxic to human leukemic cell lines. Its cytotoxicity and chemopreventive activities may be attributed to its ability to induce apoptosis.Burns J Gardner PT O'Neil J et al. J. Agric. Food Chem. 48 220-230 (2000).

Watson DG Oliveira EJ J. Chromatogr. B. Biomed. Sci. Appl. 723 203-210 (1999).

Mutoh M Takahashi M Fukuda K et al. Carcinogenesis. 21 959-963 (2000).

Dimas K Demetzos C Mitaku S et al. Pharmacol Res. 41 85-88 (2000).

Wang IK Lin-Shiau SY Lin JK. Eur. J. Cancer. 35 1517-1525 (1999).

O

OOH

HO

OH

OH

OH

O

O

O

O

O

O

CH3

H

CH3

RH

CH3

H3C

OH

H

HO

H C

CH3

H

H3C

OCH3

H

H

OH

CH3

B R CH CH

B R=CH

N N

NH

O

O

CH3

HOO

O(CH2)5CH3

H

NN

HN

O

O

H3C

OHO

HO

H

NN

HN

O

O

H3C

OHO

H3CO

H


K0030 Kahweol (See page 12 for more information) 10 mgC20H26O3 FW 314.19 MP: 143-144oC [6984-43-5] 25 mgNatural product isolated from the unsaponifiable fraction of petroleum ether 100 mgextract of coffee beans. It is an inducer of the detoxifying enzyme, 500 mgglutathione S-transferase.

Bengis RO Anderson RJ. J. Biol. Chem. 47 99-113 (1932).

Slotta KH Neisser K. Ber. 71 1991-1994 (1938).

Lam LKT Sparnins VL Wattenberg LW. Cancer Res. 42 1193-1198 (1982).

K0031 Kahweol acetate 10 mgC20H28O FW 356.47 MP: 133.5-136oC [81760-4706] 25 mgInducer of glutathione S-transferase. 100 mgLam LKT Sparnins VL Wattenberg LW. J. Med. Chem. 30 1399-1403 (1987). 500 mg

K0034 Kahweol eicosanate 10 mgC 0H6 O FW 608.93 [108214-32-0] 25 mg

100 mg

K0036 Kahweol linoleate 10 mgC38H56O FW 576.85 [108214-29-5] 25 mg

100 mg

K0038 Kahweol oleate 10 mgC38H58O FW 578 86 [108214-30-8] 25 mg

100 mg

K0032 Kahweol palmitate 10 mgC36H56O FW 552.42 MP: 32oC [81760-45-4] 25 mgNaturally occurring ester present in green coffee beans that inhibits mammary 100 mgtumor formation. 500 mgLam LKT Sparnins VL Wattenberg LW. Cancer Res. 42 1193-1198 (1982).

K0040 Kahweol stearate 10 mgC38H60O FW 580.88 [108214-31-9] 25 mg

100 mg

K0133 Kainic Acid 10 mgC10H15NO FW 213.23 [487-79-6] 25 mgKainic acid induces partial reversible damage to progressive neurogeneration. 100 mgSun H Hashino E Ding DL Salvi RJ. J Comp Neurol 430 172-181 (2001).

K0144 Kallikrein Inhibitor 1 mgC35H55N11O9 FW 773.9 [97145-43-2] 2 mg

5 mg

K0053 Kanamycin A 1 gC18H36N O11 FW 484.50 [59-01-8] 5 gKanamycins are aminoglycoside antibacterials. Kanamycin A has been shown to 25 g be more potent than metronidazole and clarithromycin against Helicobacter pylori.Irie Y Tateda K Matsumoto T et al. J Antimicrob Chemother. 40 235-40 (1997).

Kwon M Chun SM Jeong S et al. Mol Cells. 11 303-11 (2001).

HN

CH2COOHC

COOH

CH3

H2C

O

O

NH2

O

OH

HO

O

H2N

HO

HO

H2N

OH

H2N

OH HO

O

Ac-Pro-Phe-Arg-Ser-Val-Gln-

NH2

OH

OH

O

O

OC(CH2) 8CH3

OH

CH2) C 2

OH

O

H2

( H2)4CH3

O

OH

C(CH )6CH

O

CH (CH ) CH3

OC(CH2) 4CH3

OH

O

O

O

OH

OC(CH2)16CH3

O


K0054 Kanamycin B 100 mgC18H37N5O10 FW 483.51 [4696-76-8] 250 mg

1 g

K0172 Kassinin 1 mgC59H95N15O18S FW 1334.6 [63968-82-1] 2 mgA tachykinin peptide of the skin of the African frog Kassina senegalensis. 5 mgPerfumi M de Caro G Panocka I et al. Pharamacol Res Commun. 20 Suppl 5 67-70 (1988).

K0276 Katacalcin 0.5 mgC97H15 N3 O36S2 FW 2436.64 [85916-47-8] 1 mgA calcium-lowering hormone that may be a useful marker for the detection of 2.5 mgmedullary thyroid carcinoma.Ali-Rachedi A Varndell IM Facer P et al. J Clin Endocrinol Metab. 57 680-682 (1983).

Takami H Shikata J Horie H et al. J Surg Oncol. 44 205-207 (1990).

K0282 Kavalactones Mixture 1 ml100 µg each of 13 kava compounds/ mL acetonitrile

K0088 Kawain 5 mgC1 H1 O3 FW 230.26 [3155-48-4] 10 mgA major component of kava kava extract, has antinociceptive activity.

Jamieson DD Duffield PH. Clin Exp Pharm Physiol 16 496-507 (1990).

K1650 Kemptide 1 mgC32H61N13O9 FW 771.92 [65189-71-1] 2 mgA synthetic heptapeptide substrate for kinases that maintains cell membrane 5 mg intactness when added to cultured cells.

Foxwell BM Band HA Long J et al. Br J Cancer. 57 489-493 (1988).

Kubler D Pyerin W Bill O et al. J Biol Chem. 264 14549-14555 (1989).

K1653 Kendomycin 100 µg(-)-TAN 2162 500 µgC29H 2O6 FW 486.64 [183202-73-5]A potent endothelin receptor antagonist isolated from Streptomyces violaceruber.

It is an antiosteoporotic with antibacterial and cytotoxic activity.

Zeeck A Bode HB. J Chem Soc Perkin Trans. 323 (2000).

K1655 Kenpaullone 1 mgC16H11BrN2O FW 327.18 [142273-20-9] 5 mgA potent inhibitor of CDK1/cyclin B, that also inhibits CDK2/cyclin A, CDK2/cycline E,

and CDK5/p25. Acts by competitive inhibition of ATP binding.

Zaharevitz DW Gussio R Leost M et al. Cancer Res. 59 2566-9 (1999).

Cole A Frame S Cohen P. Biochem J. 377 249-55 (2004).

K1678 Ketanserin 25 mgC22H22FNO3 FW 395.43 [74050-98-9] 100 mgA serotonin antagonist which displays alpha-adernergic and dopamine 500 mgreceptor affinity. It has the highest affinity for the serotonin 5HT2A receptor.

Synapse 42(2), 104-114.

Neuroscience 21(1); 123-139

O

O

NH2

O

OH

HO

O

H2N

HO

HO

H2N

OH

H2N

NH2 HO

O

CH3

O

HO

CH3

CH3

H3C

HO

OH

CH3

H

H

CH3

H3C

O

HN

HN

O

Br

OO

OCH3

H-Asp-Met-Ser-Ser-Asp-Leu-

Glu-Arg-Asp-His-Arg-Pro-His-

Val-Ser-Met-Pro-Gln-Asn-Ala-

Asn-OH


NH2

H-Leu-Arg-Arg-Ala-Ser-Leu-

Gly-OH

N

HN

O

O

N

O

F


K1676 Ketoconazole (See page 16 for more information) 5 gC26H28Cl2N O FW 531.43 m p. 1460C [65277-42-1] 25 gAn inhibitor of cytochrome P-450 in steroid biosynthesis. Antineoplastic, antimetastatic,

antipsoriatic. Inhibits lipoxygenase and thromboxane synthase activities.

Lelcuk S Huval WV Valeri CR et al. J. Trauma 24 393-396 (1984).

Tucker WFG MacNeil S. Br. Med. J. 293 882 (1986).

Nardone PA Slotman GJ Vezeridis MP. J. Surg. Res. 44 425-429 (1988).

Van Wauwe JP Janssen PAJ. J. Med. Chem. 32 2231-2239 (1989).

K1674 Ketolide resistance Peptide MRFFV 1 mgC3 H50N8O6S FW 698.9 5 mg

K1677 Ketoprofen 5 gC16H1 O3 FW 254.28 m.p. 93-960C [2207-15-4] 25 gA non-steroidal anti-inflammatory agent with significant 100 gchemopreventive activity in colon and urinary bladder carcinogenesis.Reddy BS Tokumo K Kulkarni N et al. Carcinogenesis. 13 1019-1023 (1992).

Rao KV. Detrisai CJ Steele VE et al. Carcinogenesis. 17 1435-1438 (1996).

K1978 Ketorolac Tromethamine 1 gC19H2 N2O6 FW 376.40 [74103-07-4] 5 gA pyrrolizine carboxylic acid derivative structurally related to indomethacin. It is a 25 gnon-steroidal anti-inflammatory agent used for analgesia for postoperative pain and

inhibits cyclooxygenase activity.

Laneuville O Breuer DK DeWitt DL et al. J. Pharmacol. Exp. Ther. 271 927-934 (1994).

K1776 Ketotifen Fumarate 500 mgC19H19NOS CH H O FW 425.5 [34580-14-8] 1 gInhibits spontaneous motor activity and amphetamine hypermotility while inducing L-DOPA

motor stimulation in mice and rats. Anti-asmatic activity and mast cell stabilizer.

Martin U. Roemer D. Monographs in Allergy. 12 145-149 (1977).

Wuethrich B. Radielovic P. Debelic M. Intl J Clinl Pharmacol Biopharm. 16 424-9 (1978).

K2412 K-G-D-S 1 mgC15H27N5O8 FW 405.41 2 mg

5 mg

K3352 Kinetensin 1 mgC56H85N17O11 FW 1172.4 [103131-69-7] 2 mgIncreases vascular permeability and induces histamine release in rat peritoneal 5 mg mast cells.Sydbom A Ware J Mogard MH. Agents Actions. 27 68-71 (1989).

K4401 KL-1 1 mgC53H90N16O18 FW 1239.4 2 mg

5 mg

K6864 K-R-Q-H-P-G 0.5 mgC30H51N13O8 FW 721.82 1 mgRegulates the synthesis of TRH in the pituitary gland and acts as a neurotransmitter. 2.5 mg

O

O

HO

N

N

CH3

O

N

N

Cl

Cl

Met-Arg-Phe-Phe-Val

H-Lys-Gly-Asp-Ser-OH

H-Leu-Pro-Pro-Val-Ala-Ala-

Ser-Ser-Leu-Arg-Asn-Asp-OH

H- le-Ala-Arg-Arg-His-Pro-Tyr-

Phe-Leu-OH

H-Lys-Arg-Gln-His-Pro-Gly-OH


K9858 Kyotorphin 5 mgC15H23N5O FW 337.4 [70904-56-2] 10 mgAn analgesic neuropeptide that inhibits peptide uptake. 25 mgHussain I Zanic-Grubisic T Kudo Y Boyd CA. FEBS Lett. 508 350-354 (2001).

Hazato T Kase R Ueda H et al. Biochem Int. 12 379-383 (1986).

L0107 Lactacystin 200 µgC15H2 N2O7S FW 376.4 [133343-34-7]Proteasome inhibitor, induces apoptosis and inhibits angiogenesis.

Tomoda H Omura S. Yakugaku Zasshi 120 935-49 (2000).

Wagenknecht B et al. J Neurochem 75 2288-97 (2000).

Kumeda SI et al. Anticancer Res 19 3961-8 (1999).

L0109 Lactalbumin 1 lb[9013-90-5] 5 lbA non soluble denatured protein fraction from milk. Found to have antiproliferativeactivity which is useful in the prevention of colon cancer and breast cancer.Ganjam LS Thornton WH Jr Marshall RT MacDonald RS. J Dairy Sci. 80 2325-9 (1997).

Biffi A Coradini D Larsen R et al. Nutr Cancer. 28 93-9 (1997).

L0209 Lactoferrin (Bovine) 10 mgProtein contents 96-98% [146897-68-9] 50 mgAn antimicrobial peptide, which has significant antimicrobial activity against 100 mgHelicobacter species. It has antifungal activity.Dial EJ Hall LR Serna H Romero JJ et al. Dig Dis Sci. 43 2750-6 (1998).

Wakabayashi H Uchida K Yamauchi K et al. J Antimicrob Chemother. 46 595-602 (2000).

L0211 Lactulose 10 gC12H22O11 FW 342.30 [4618-18-2] 25 gA keto analogue of lactose. In humans, lactulose reduced dehydroxylation of

chenodeoxycholic acid to the potentially toxic secondary bile acid lithocholic by over

90%. It is also a substrate for preferential growth of Bifidobacterium longum, a bacterium

which has been shown to afford protection against colon tumorigenesis.Hennigan TW Sian M Matthews J Allen-Mersh TG. Surg Oncol. 4 31-4 (1995).

Owen RW. Scand J Gasteroenterol. 222 76-82 (1977).

Challa A Rao DR Chawan CB Shackel Ford L. Carcinogenesis. 18 517-21 (1997).

L0226 Lagochiline 25 mgC20H36O5 FW 356.60 100 mgA diterpene from the Turkestan Mint plant. It has hemostatic, hypotensive, and

sedative effects.

Schultes RE. Science. 163 245-54 (1969).

L0248 Laminin peptide YIGSR 1 mg Laminin fragment 929-933 5 mg

L0249 Laminin peptide YIGSR-NH2 1 mg5 mg

L0250 Laminin peptide SIKVAV 1 mg5 mg

L0251 Laminin peptide CDPGYIGSR 1 mg5 mg

HOO

H H

H

OHH

OH

CH2OH

H

O

H

H CH2OH

HOH OHO

CH2OH

CH2OH

CH2OH

O

HO

HOH2C

H3CHN

O COOH

S

NH

HOCH3

O

H3C

CH3

OH

O

H-Tyr-Arg-OH


L0350 Lamivudine 1 gC8H11N3O3S FW 229.26 [134678-17-4] 5 gA potent nucleoside analog reverse transcriptase inhibitor (nRTI). An analog of 25 gcytidine that can inhibit both types (1 and 2) of HIV reverse transcriptase as well as the

reverse transcriptase of hepatitis B.

Butt YM, et al. Pediatr. Dev. Pathol. 11 35-38 (2008).Perez-Olmeda M, et al. J. Med. Virol. 81 211-216 (2009).

L0349 Lamotrigine 25 mgC9H7Cl2N5 FW 255.01 [84057-84-1] 100 mgAn anti-convulsant drug used to treat siezures, neuropathic pain and epilepsy. 500 mgBackonja MM Neurology. 59 (5 Suppl 2) S14-7 (2002).

Karceski S Morrell MJ Carpenter D. Epilepsy Behav. Suppl 1 S1-64; quiz S65-7 (2005).

L0254 Lansoprazole (See page 27 for more information) 250 mgC16H1 F3N3O2S FW 369.36 [103577-45-3] 1 gA proton pump inhibitor. It inhibits H /K( ) ATPase, resulting in potent and long-lasting

inhibition of gastric acid secretion. It has also shown antibacterial activity against H. pylori.Iwahi T Satoh H Nakao M et al. Antimicrob Agents Chemother. 35 490-6 (1991).

Nagaya H Satoh H. Nippon Rinsho. 50 26-32 (1992).

Li XQ Andersson TB Ahlstrom M et al. Drug Metab Dispos. 32 821-7 (2004).

L0360 Lapatinib Ditosylate 10 mgC29H26ClFN O S.H2O.(C6H6O3S)2 FW 925.46 [388082-78-8] 25 mgA treatment FDA approved for breast cancer. It is used in patients whose cancer is 100 mg HER2 positive. Used for treatment of solidt tumors and is an ATP competitive

epidermal growth factor and HER2 dual tyrosine kinase inhibitor.

Feng Yu-fei. Zhongguo Xinyao Zazhi (2007) 16(23) 1990-1993.

Nelson M. H. Therapeutics and Clinical Risk Management (2007) 3(4) 665-673.

L0060 Lappaconitine (See page 19 for more information) 25 mgC32H N2O8 FW 584.70 [32854-75-4] 100 mgAn alkaloid isolated from the root of Aconltitum sinomantanum Nakai has 500 mg strong analgesic activity that does not involve the opioid receptor. It was shown to have class-I antiarrhythmic action and irreversibly blocks cloned human heart (hH1) channels by binding to the site 2 receptor.Ono M Satoh T. Res Comm. Chem Path Pharm. 63 13-25 (1989).

Heubach JF Schule A. Planta Medica 64 22-26 (1998).

Wright SN. Mol Pharm. 59 183-192 (2001).

L0076 Latrunculin A (See page 22 for more information) 1 mgC22H31NO5S FW 421.55 [76343-93-6] 5 mgIt is an actin-binding marine toxin that distrupts microfilament-mediated processes. It inhibits

actin polymerisation in vitro and in vivo. Coue M.; Brenner S.L.; Spector I.; Korn E.D. FEBS letters. 213 316-318 (1987).

Morton W. M.; Ayscough K.R.; McLaughlin P.J. Nature Cell Biol. 2 376-378 (2000).

Spector I.; Shochet N.R.; Kashman Y.; Groweiss A. Science 214 493-495 (1983).

YarmolaEG;SomasundaramT;BoringTA; SpectorI; Bubb M.R.J.Biol.Chem.275 28120-28127(2000)

L0284 Lavendustin A 1 mgC21H19NO6 FW 381.38 [125697-92-9] 5 mgProtein tyrosine kinase inhibitor. Suppresses VEGF-induced angiogenesis.

Onoda T Iinuma H Sasaki Y et al. J Nat Prod. 52 1252-7 (1989).

Hu DE Fan TP. Brit J Pharmacol. 114 262-8 (1995).

N

OH

OH

OH

OH

COOH

NHH3C

O

O

O

N

OH

OCH3

H3C

OCH3

OH

OCH3

O

H3C

CH3

O

O NH

S

O

HO

N

N

HN Cl

O

F

O

NHS

O

O

H3C

H2O

SOH

O

O

2

N

NN

Cl

Cl

H2N NH2


L1817 Leflunomide 100 mgC12H9F3N2O2 FW 270.2 [75706-12-6] 500 mgAn immunomodulator, inhibits tyrosine phosphorylation and pyrimidine 1 g nucleotide synthesis.Xu X Shen J Mall JW et al. Biochem Pharmacol. 58 1405-13 (1999).

Manna SK Mukhopadhyay A Aggarwal BB. J Immunol. 165 5962-9 (2000).

L1628 Ac-LEHD-PNA 1 mgC29H38N8O11 FW 674.7 2 mg

5 mg

L1660 Leptin (22-56), human 1 mgOBGRP(22-56), human

C171H298N50O56 FW 3950.6

L1661 Leptin (116-130), mouse 0.5 mgC6 H107N18O25S1 FW 1560.74 1 mgSignificantly reduces weight gain by injected female C57BL/6J ob/ob mice. 2.5 mgGrasso P Leinung MC Ingher SP Lee DW. Endocrinology. 138 1413-1418 (1997).

L1761 Leptomycin B 1 µgC33H 8O6 FW 540.73 [87081-35-4] 5 µgAn antifungal antibiotic, found to be a potent antitumor agent. It is suggested that the antitumor

effect is related to cytochrome c release, activation of caspases, and selective down-regulation of

Mc1-1 and XIAP. Leptomycin B has also been found to inactivate the export receptor CRM1.

Sasaki H Yoshida M Beppu T. Radiat Res. 129 163-70 (1992).

Jang BC Paik JH Jeong HY et al. Biochem Pharmacol. 68 263-74 (2004).

Meissner T Krause E Vinkemeier U. FEBS Lett. 576 27-30 (2004).

L1878 Letrozole 25 mgC17H11N5 FW 285.30 [112809-51-5] 50 mgA non-steroidal antiaromatase used in the treatment of advanced breast cancer 100 mg and chemoprevention.

Ingle JN. Oncology (Huntingt). 15 28-34 (2001).

Bhatnagar AS Hausler A Schieweck K et al. J Steroid Biochem Mol Biol. 37 1021-7 (1990).

Brodie AM. J Steroid Biochem Mol Biol. 49 281-7 (1994).

L1980 Leucokinin I 1 mgC 1H52N11O12 FW 891.93 [104600-89-7] 2 mgA neuropeptide that was originally isolated from the cockroach Leucophaea 5 mgmaderae.Lee BH Kang H Kwon D et al. Tissue Cell. 30 74-85 (1998).

L1981 Leucokinin VIII 1 mgC 2H52N10O11 FW 872.94 2 mg

5 mg

L1983 Leucomyosuppressin (lms) 0.5 mgC59H8 N16O15 FW 1257.44 [106884-19-9] 1 mgAn insect myoinhibitory neuropeptide that has been shown to inhibit 2.5 mgcontraction of both visceral and skeletal muscles of insects and may also be associated with feeding and digestion.Fuse M Bendena WG Donly BC et al. J Comp Neurol. 395 328-341 (1998).

Meola SM Wright MS Holman GM Thompson JM. J Med Entomol. 28 712-718 (1991).

NC

N

CN

N

N

Ac-Leu-Glu-His-Asp-pNA

Val-Pro-Ile-Gln-Lys-Val-Gln-

Asp-Asp-Thr-Lys-Thr-Leu- le-

Lys-Thr- le-Val-Thr-Arg- le-

Asn-Asp- le-Ser-His-Thr-Gln-

Ser-Val-Ser-Ser-Lys-Gln-Lys

H-Ser-Cys-Ser-Leu-Pro-Gln-

Thr-Ser-Gly-Leu-Gln-Lys-Pro-

Glu-Ser-OH

H-Asp-Pro-Ala-Phe-Asn-Ser-Trp-

Gly-NH2

H-Gly-Ala-Ser-Phe-Tyr-Ser-Trp-

Gly-NH2

pGlu-Asp-Val-Asp-His-Val-Phe-

Leu-Arg-Phe-NH2

O

H3C

O

H3C

OH

H3C

O

H3C

H3C

H3C

OH

H3C

O

H3C


Leucovorin Calcium (See Calcium folinate, pentahydrate)

L1881 Leuprolide Acetate 1 mgC59H8 N16O12

. C2H O2 FW 1269.65 [74381-53-6] 5 mg

A gonadotropin inhibitor that decreases testosterone levels in men and estrogen levels in

women. Implantable leuprolide delivery system provides suppression of testosterone in patients with advanced prostate cancer. In experimental animals it was found to inhibit chemically induced mammary tumor formation as effectively as surgical ophorectomy.Fowler JE Gottesman JE Reid CF et al. J Urol. 164 730-4 (2000).

Jett EA Lerner Mr Light foot SA et al. Breast Cancer Res Treat. 58 131-6 (1999).

L1682 Levamisole Hydrochloride 5 gC11H12N2S.HCl FW 240.76 [16595-80-5] 10 gAn anti-neoplastic, immuno-modulating agent that is used as an adjuvant in colon cancer therapy. It selectively induces apoptosis and growth arrest in cultured human micro-and macro vascular endothelial cells. In experimental animals, levamisole reduces both the number and size of

tumors in the colon and buccal pouch.

Artwohl M Holzenbein T Wagner et al. BR J Pharmacol. 131 1577-1583 (2000).

Suzuki H Yamamoto J Iwata Y et al. Jpn J Surg. 16 152-5 (1986).

Eisenberg E Shakilar G. Oral Surg Oral Pathol. 43 562-71 (1997).

L1784 Levetiracetam 100 mgC8H1 N2O2 FW 170.21 [102767-28-2] 250 mgAn anticonvulsant drug used to treat epilepsy. Binds to a synaptic vesicle 1 g protein SV2A which may lead to impeded nerve connection.

Lee Jong Woo. New England Journal of Medicine (2008) 359(17) 1853.

L1735 Levitide 1 mgC66H119N21O19S FW 1542.88 [114281-19-5] 2 mgOriginally isolated from skin secretions of the SouthAfrican frog Xenopus laevis. 5 mgPoulter L Terry AS Williams DH et al. J Biol Chem. 263 3279-3283 (1988).

L1780 Levocetirizine Dihydrochloride 1 gC21H25ClN2O3

.2HCl FW 461.81 [130018-87-0] 5 gThe active R-enantiomer of cetirizine. It is a selective H1 receptor antagonist 25 gwith potential anti-inflammatory effects.

Thomson L Blaylock MG Sexton DW et al. Clin Exp Allergy. 32 1187-92 (2002).

Day JH Eliis AK Rafeiro E. Med Actual. 40 415-21 (2004).

L1782 Levodopa 1 gC9H11NO FW 197.19 [59-92-7] 5 gThe natural form of DOPA used in the treatment of Parkinson's disease. 10 gMorris JG. Clin Exp Neurol. 15 24-50 (1978).

L1786 Levofloxacin Hydrochloride (See page 16 for more info) 500 mgC18H20FN3O .HCl.H2O FW 415 84 [100986-85-4] 1 gThe optical S-(-) isomer of the fluoroquinolone antibacterial, ofloxacin. It 5 ghas twice the potency of ofloxacin.

Davis R Bryson HM. Drugs 47 677-700 (1994).

L1684 Levonorgestrel 100 mg D(-)Norgestrel 500 mgC21H28O2 FW 312.45 m.p. 235-2370C [797-63-7] 1 gA synthetic progestin that binds to progesterone and androgen receptors but not the

estrogen receptor. It induces apoptosis in ovarian epithelium cells.Lemus AE Vilchis F Damsky R. J Steroid Biochem Mol Biol. 41 881-90 (1992).

Rodriguez GC Walmer DK Cline M et al. J Soc Gynecol Investig. 5 271-6 (1998).

OH

HO

HO

O

NH2

O

H3COH

C CH

N

N N

O

CO2HF

.HCl . H2O

O

H3C

H

CH3

N

N

O COOHCl

.2HCl

N

N

S

H

pGlu-His-Trp-Ser-Tyr-D-Leu-

Leu-Arg-Pro-NHEt

pGlu-Gly-Met- le-Gly-Thr-Leu-

Thr-Ser-Lys-Arg- le-Lys-Gln-NH2

N

O

O

NH2

HH3C

www.lktlabs com 163 To Order Call 1-888-558-5227

L1884 Levosimendan 100 mgC1 H12N6O FW 280.28 [141505-33-1] 250 mgA Ca(2+) sensitizer that increases contractile force of the myocardium by 1 genhancing the sensitivity of myofilaments to calcium without increasing intracellular

calcium concentration. It has been shown to reduce circulating proinflammatory

cytokine interleukin-6 and soluble apoptosis mediators.

Udvary E Papp JG Vegh A. Br J Pharmacol. 114 656-61 (1995).

Parissis JT Adamopoulos S Antoniades C et al. Am J Cardiol. 93 1309-12 (2004).

Eriksson O Pollesello P Haikala H. J Cardiovasc Pharmacol. 44 316-21 (2004).

Levothyroxine sodium (See L-thyroxine sodium salt pentahydrate)

L3250 D-Limonene 500 mlC10H16 FW 136.23 [5989-27-5]A monoterpene found to prevent mammary cancer by inducing hepatic glutathione-S-transferase and uridine diphosphoglucuronosyl transferase. It inhibits isoprenylation

of small G-proteins.

Elegbede JA Maltzman TH Elson CE Gould MN. Carcinogenesis. 14 1221-1223 (1993).

Gould MN. Environ Health Perspect. 105 977-979 (1997).

L3550 Limonin 50 mgEvodine 100 mgC26H30O8 FW 470.52 m.p. 298-3000C [1180-71-8] 500 mgNatural product isolated from grapefruit seed. It is one of the bitter principles of citrus. It was found to inhibit chemically induced carcinogenesis. It also possesses antifeedant properties.

Rouseff RL J Agric. Food Chem. 30 504-507 (1982).

Maier VP Hasegawa S. Bennett RD et al. Protect Ecol. 6 91(1984).

L3551 Limonin Glucoside 1 mgLimonin 17 β-D-glucopyranoside 5 mgC32H 2O1 FW 650 67Natural product present in grape fruit and orange juices. Found to inhibit chemical carcinogenesis.

Miller EG Gonzales-Sanders AP Couvillon AM et al. Nutr Cancer 17 1-7 (1992).

L3454 Lincomycin Hydrochloride 1 gC18H3 N2O6S.HCl.H2O FW 443.00 [7179-49-9] 5 gA macrolide antibiotic that is bacterostatic against staphylococcus aureus. It 25 g inhibits protein synthesis by first binding to the ribosome in competition with

aminoacyl-tRNA. Subsequent interference continues to affect the binding of the

isomerized ribosome-aminoacyl-tRNA complex.

Heman-Ackah SM. J Pharm Sci. 64 1621-6 (1975).

Kallia-Raftopoulos S Kalpaxis DL Coutsogeorgopoulos C. Arch Biochem Biophys. 298 332-9 (1992).

L3453 Linezolid 1 gC16H20FN3O FW 337.35 [165800-03-3] 5 gIs a synthetic antibiotic used for the treatment of serious infections caused by 25 gGram-positive bacteria that are resistant to several other antibiotics.

Stevens DL et al. Clin. Infect. Dis. 34 1481 (2002).

L3561 D,L-α-Lipoic acid 1 gD,L-Thioctic acid 5 gC8H1 O2S2 FW 206.32 m.p. 58-620C [1077-28-7] 25 gAn antioxidant, inhibits protein oxidative modification of human low density lipoprotein.

Matsugo Yan LJ Konishi T et al. Biochem Biophys Res Commun. 243 819-824 (1997).

O

N

SCH3

OH

OH

OH

CH

CH

CH3

NH

HO

O

CH3

H3C

S S

CO2H

CO2H

O

O OH

H

OH3C

CH3

O

OO

OH

HO

OH

CH2OH

O

O

O

O

CH3

O

CH3O

OO

O

H3C CH3

NHN

OHN

N

NC

NC

H3C

Ty -Gl -Gly-Ph


L3362 β-Lipotropin (61-64) 5 mgC22H26N O6 FW 442.48 [60254-82-2] 10 mg

25 mg

L3374 Lisinopril (See page 25 for more information) 100 mgC21H31N3O5

.2H2O FW 441.52 [83915-83-7] 1 gAn angiotensin-converting enzyme inhibitor. It blocks AT1a-receptor signaling 5 g which may inhibit angiogenesis, growth and metastasis of tumors.

Goa KL Balfour JA Zuanetti G. Drugs 52 564-588 (1996).

Fujita M Hayashi I Yamashina S. Biochem Biophys Res Comm. 294 441-447 (2002).

L3577 Litorin 1 mgC51H68N1 O11S FW 1085.28 [55749-97-8] 2 mgA bombesin-like neuropeptide that may be involved in the physiological 5 mg regulation of thermal homeostasis.

Esakov AI Ashmarin IP Serova ON et al. Biomed Sci. 1 610-612 (1990).

Tartara A Bo P Savoldi F. Peptides. 3 125-127 (1982).

L5822 Lofexidine Hydrochloride 1 gC11H12Cl2N2O FW 295.60 [21498-08-8] 5 gIt is an α2-adrenergic agonist useful in the management of opioid drawer. 25 gTimmermansPB van Kemenade JE Harms YM et al.Arch Int Pharmacodyn Ther.261 23-35 (1983).

Brown AS Fleming PM. J Psychopharmacol. 12 93-6 (1998).

L5749 Lomefloxacin Hydrochloride 1 gC17H19F2N3O3

.HCl FW 387.81 [98079-52-8] 5 gA fluoroquinolone antibiotic that inhibis DNA gyrase. 10 gPiddock LJ Hall MC Wise R. Antimicrob Agents Chemother. 34 1088-93 (1990).

L5750 Lomeguatrib 10 mgC10H8BrN5OS FW 326.17 [192441-08-0] 25 mgPotent Inhibitor of O6-Alkylguanine-DNA-Alkyltransferase 100 mgClin Cancer Res March 1 2006 12 1577-1584; doi 10.1158/1078-0432.CCR-05-219

L5751 Lomerizine Hydrochloride 500 mgC27H30F2N2O3

.2HCl FW 541.47 [101477-54-7] 1 gA Ca2 channel blocker used as an anti-migraine agent. 5 gHaraH ShimazawaM Hashimoto M Sukamoto T.Nippon Yakurigaku Zasshi.112 138P-142P(1998).

L5648 Lomustine 50 mgCCNU 100 mgC9H16ClN3O2 FW 233.7 [13010-47-4] 500 mgPosseses antitumor activity similar to carmustine.

Marshall ES Holdaway KM Shaw JH et al. Oncol Res 5 301-9 (1993).

L5658 Lonidamine 5 mgC15H10Cl2N2O2 FW 321.16 [50264-69-2] 25 mgA mitochondria-targeting antitumor agent. It has been shown to induce apoptosis 100 mg in certain cells, and potentiate cisplatin and paclitaxel activity.

Orlandi L Zaffaroni N Bearzatto A et al. Int J Cancer. 78 377-84 (1998).

De Lena M Lorusso V Latorre A et al. Eur J Cancer. 37 364-8 (2001).

Miyato Y Ando K. J Radiat Res (Tokyo). 45 189-94 (2004).

N

N

COOH

Cl Cl

HN N

O

Cl

NO

N

N

H3CO

F

F

OCH3

OCH3

2HCl

N

HN

O

Cl

CH3

ClHCl

NH

N

COOH

COOHO

2H2O

NH2

Tyr-Gly-Gly-Phe

pGlu-Gln-Trp-Ala-Val-Gly-His-

Phe-Met-NH2


L5660 Loperamide Hydrochloride 5 gC29H33ClN2O2

.HCl FW 513 51 [34552-83-5] 25 gA mu-opioid agonist that is an antidiarrhoeal drug which inhibits intestinal motility and

secretion. It has been shown to suppress the calcium-influx in dorsal root ganglion neurons.

Hagiwara K Nakagawasai O Murata A et al. Neurosci Res. 46 493-7 (2003).

Klaren PH Giesberts AN Chapman J et al. J Pharm Pharmacol. 52 679-86 (2000).

L5862 Lopinavir 500 mgC15H10Cl2N2O2 FW 321.16 [192725-17-0] 1 gAntiretroviral of the protease inhibitor class. Selectively inhibits HIV protease. 5 gMurphy R.L. et al. Antiviral Ther. 4 Suppl. 3 85 (1999)

L5767 Loratadine 500 mgC22H23ClN2O2 FW 382 88 [79794-75-5] 1 gA non sedative antihistamine, inhibits histamine-induced activities of IL-6 and 5 g IL-8 secretion in endothelial cells.

Roman IJ Danzig MR. Clin Rev Allergy. 11 89-110 (1993).

Molet S Gosset P Lassalle P et al. Clin Exp Allergy. 27 1167-74 (1997).

L5769 Lorglumide Sodium 25 mgC22H31Cl2N2O Na FW 481.39 [97964-56-2] 100 mgA specific cholecytokinin receptor antagonist. It inhibits the effects of cholecytokinin on

pancreatic growth and the development of pancreatic lesions and chemically induced

carcinogenesis of the pancreas in rats.

Meijers M Appel MJ et al. Carcinogenesis. 13 1525-8 (1992).

Watanapa P Flaks B Oztas Het al. J Cancer. 67 663-7 (1993).

Sperti C Militello C et al. J Surg Oncol. 57 11-6 (1994).

L5870 Lornoxicam 100 mgC13H10ClN3O S FW 371 82 [70374-39-9] 250 mgIs a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class with 1 ganalgesic, anti-inflammatory and antipyretic properties.

Tricerri M. et al. Chem. Phys. Lipids 71 61 (1994).

L5873 Losartan Potassium 1 gC22H22ClKN6O FW 461.01 [124750-99-8] 5 gAn angiotensin II subtype I (AT1) receptor antagonist used for the treatment 25 gof hypertension. It inhibits platelet activity by suppressing thrombin-

induced calcium transients and thromboxane release.

McIntyre M Caffe SE Michalak RA Reid JL. Pharmacol Ther 74 181-94 (1997).

Schwemmer M Sommer O Bassenge E. Cardiovasc Drugs Ther. 15 301-7 (2001).

Lovastatin (See Mevinolin)

L5993 Loxoprofen 100 mgC15H18O3 FW 246.3 [68767-14-6] 250 mgA non-steroidal anti-inflammatory drug. Quickly converted to the trans-alcohol 1 g metabolite. Similar to ibuprofen and naproxen. Cycloxygenase inhibitor.

Matsumoto M. Neuroscience letters (2006) 397(3) 249-53.

N

N

O CH3O

Cl

Cl

Cl

NH

N

O

(CH2)4CH3

(CH2)4CH3

OO

Na

O

Cl N

HO

N

CH3

CH3

O

HCl

HO

CH3

O

O

O


L8248 Lumaricoxib (See page 17 for more information) 100 mgC15H13CLFNO2 FW 293.72 [220991-20-8] 250 mgIs a Cox-2 selective inhibitor NSAID. A member of the arylalkanoic acid family 1 gof NSAIDs it binds to a separate site than the other Cox-2 inhibitors. Concerns

that it may cause liver failure prompted withdraw from the market.

Fox A. Pain (2004) 107(1-2) 33-40

L8262 Lupinine 25 mgC10H19NO FW 169.26 [486-70-4] 100 mgAn alkaloid isolate from Anabisis aphylla can reduce the effect of ethanol anesthesia.Mirzaev S. Farmakol Toksikol. 41 52-5 (1978).

L8276 Luteinizing Hormone Releasing Hormone 1 mgLHRH 2 mgC55H76N17O13 FW 1182.3 [9034-40-6] 5 mgA decapeptide found to inhibit ovulation in the rat.Rivier JE Vale WW. Life Sci. 23 869-876 (1978).

L8277 [Gln8] LH-RH, chicken 1 mgC5 H71N15O1 FW 1154.28 [47922-48-5] 2 mg

5 mg

L8278 LH-RH, salmon 1 mgC60H73N15O13 FW 1212.36 [86073-88-3] 2 mg

5 mg

L2876 Luteinizing Hormone Releasing Hormone-III, 1 mg

Lamprey 2 mgLHRH-III, lamprey 5 mgC55H76N17O13 FW 1182.30 [9034-40-6]

L8377 Luteolin 100 mgC15H10O6 FW 286.24 [491-70-3] 500 mgA flavonoid isolated from the fruit of Vitex rotundifolia. It is an 1 gapoptosis inducer with anti-proliferative effects.Molnar J Beladi I Domonkos K et al. Neoplasma 28 11-8 (1981).

Yee SB Lee JH Chung HY et al. Arch Pharm Res. 26 151-6 (2003).

L9609 Lycopene (See page 13 for more information) 1 mgC 0H56 FW 536.88 m.p. 172-1730C [502-65-8] 5 mgA carotenoid present in ripe fruits, particularly tomatoes. It is an antioxidant that 10 mappears to have cancer chemopreventive properties, and helps AIDS patients.Rousseau EJ Davison AJ Dunn B. Free Radic Biol Med. 13 407-433 (1992).

Khachik F Beecher GR Smith JC Jr. J Cell Biochem Suppl. 22 236-246 (1995).

Periquet BA Jammes NM et al. AIDS. 9 887-893 (1995).

L9875 Lys(Boc)-Leu-Lys(Boc)-Obzl 1 gC35H59N5O8 FW 667.9

O

OH

OH

OOH

HO

N

OH

NH2

CH3

CH3

CH3

H3C

H3C

H3C

CH3

CH3

H3C

H3C

pGlu-His-Trp-Ser-Tyr-Gly-Leu-

Arg-Pro-Gly-NH2


Gln-Pro-Gly-NH2

pGlu-His-Trp-Ser-Tyr-Gly-Trp-

Leu-Pro-Gly-NH2

pGlu-His-Trp-Ser-His-Asp-Trp-

Lys-Pro-Gly-NH2

Lys(Boc)-Leu-Lys(Boc)-OBzl

HN

Cl

F

HO

O

H3C


L9874 L(+)Lysine Monohydrate 5 gC6H1 N2O2

.XH2O FW 146.19 [39665-12-8] 25 g100 g

L9880 Lysipressin Acetate Please inquireC 6H65N13O12S2 FW 1056.22 [50-57-7}

M0035 M35 0.5 mgC107H153N27O26 FW 2233.58 [142846-71-1] 1 mgA chimeric peptide that acts as a Galanin receptor antagonist which evokes the 2.5 mgacetylcholine in rats.

Ogren SO Pramanik A Land T Lang U. Eur J Pharmacol 242(1) 59-64 (1993)

M0040 M40 0.5 mgC9 H1 5N23O2 FW 1981.34 [143896-17-7] 1 mgA galanin receptor antagonist. 2.5 mgCrawley JN Robinson JK Langel U Bartfai T. Brain Research; 600(2) 268-272 (1993).

M0114 Madecassic acid 500 mgC30H 8O6 FW 504.70 [18449-41-7] 1 gOne of the three triterpenes isolated from Centella asiatica. Its wound healing 5 g property has been attributed to its abbility to stimulate collagen synthesis.

Maquart FX Bellon G Gillery P et al. Conn Tiss Res. 24 107-120 (1990).

Bonte F Dumas M Chaudagne C Meybeck A. Plant Med. 60 133-135 (1994).

M0124 Magainin 1 0.5 mgC112H177N29O28S FW 2409.9 [108433-99-4] 1 mgAn anti-microbial peptide shown to be active against many types of bacteria 2.5 mgand protozoa.Matsuzaki Harada Handa Funakoshi Fujii YajimaH MiyajimaKBiochimBiophysActa981(1);130-4(1989)

Zasloff M Martin B Chen HC. PNAS 85(3) 910-913 (1988)

M0126 Magainin 2 0.5 mgC11 H180N30O29S FW 2466.95 [108433-95-0] 1 mgAn anti-microbial peptide that permeabilizes cell membranes. 2.5 mgMatsuzaki k Sugishita K Ishibe N Uzha M Nakata S Miyajima K Epand R.

Biochemistry 37(34) 11856-11863 (1998).

M0224 MAGE-3 Antigen (271-279), human 1 mgC53H79N13O10 FW 1058.3 [160295-81-8] 2 mgA human antigen that has been recognized to code for Melinoma and has also 5 mgshown great promise for specific immunotherapy.

Gaglaou B et. al. J Experimental Medicine 179 921-930 (1994).

M0115 Magic RedTM Caspases 3 & 7 Assay Kit 25 TestsMR-(DEVD)2 100 Tests

M0116 Magic RedTM Cathepsin B Assay Kit 25 TestsMR-(RR)2 100 Tests

H3C

COOHCH3CH3

HOCH3

HO

HO

CH3

CH3

OH

NH2

NH2

HO

O


Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-

Gly-Phe-Ser-Pro-Phe-Arg-NH2

C[Cys-Tyr-Phe-Gln-Asn-Cys]-Pro-

Lys-Gly-NH2


Gly-Tyr-Leu-Leu-Gly-Pro-Pro-

Pro-Ala-Leu-Ala-Leu-Ala-NH2

Phe-Leu-Trp-Gly-Pro-Arg-Ala-

Leu-Val

H-Gly-Ile-Gly-Lys-Phe-Leu-His-

Ser-Ala-Lys-Lys-Phe-Gly-Lys-

Ala-Phe-Val-Gly-Glu-Ile-Met-

Asn-Ser-OH


Ser-Ala-Gly-Lys-Phe-Gly-Lys-


Lys-Ser-OH


M0117 Magic RedTM Cathepsin K Assay Kit 25 TestsMR-(LR)2 100 Tests

M0118 Magic RedTM Cathepsin L Assay Kit 25 TestsMR-(FR)2 100 Tests

M0125 Magnolol 10 mgC18H18O2 FW 266.34 [528-43-8] 25 mgNatural product isolated from the cortex of Magnolia officinalis, has been found 100 mg to possess many interesting biological activities. It has anti-allergic andi anti-asthmatic activity, anti-nflammatory and neuroprotective effects,

anti-proliferative and activating apoptosis in cancer cells.

Lee MM Huang HM Hsieh MT. Chinese J Physiology. 43 61-67 (2000).

Lin SY Liu JD Chang HC et al. J Cell Biochem. 84 532-544 (2002).

Lin SY Chang YT Liu JD et al. Mol Carcinogenesis. 32 73-83 (2001).

Wu Sn Chen CC Li HF et al. Thorax 57 67-74 (2002).

M0144 Malantide 1 mgC72H12 N22O21 FW 1633.93 [86555-35-3] 2 mgA cAMP synthetic peptide that performs protein kinase activity. 5 mgMurray K, England, et al Biochem 267 (3) 703-708 (1990).

M0248 Manidipine Hydrochloride 25 mgC35H38N O6 2HCl FW 683.62 [89226-75-5] 100 mgA third generation dihydropyridine calcium antagonist which casues systemic 250 mg vasodilation by inhibiting the voltage dependent calcium inward currents in smooth

muscle cells. Hypertension drug.

Roth M. American Heart Journal (1993) 125(2 Pt. 2) 598-603.

M0255 Manzamine A (See page 22 for more information) 1 mgC36H N O FW 548.76 [104196-68-1] 5 mgA β-carboline alkaloid isolated from the marine sponge Xestospongia ashmorica that

acts as a GSK-3beta inhibitor.

Ang KH Holmes MJ Higa T et al. Antimicrob. Agents Chemother. 44 1645-1649 (2000).

M0262 Maprotiline Hydrochloride 1 gC20H23N.HCl FW 313.87 [10347-81-6] 5 gAn antidepressant works as a selective noradrenaline reuptake inhibitor. It decreases

binding to 5HT2A receptors with no effect on benzodiazepine binding sites.

Pinder RM et al. Drugs 13 321 (1977).

M0272 Mas7 1 mgC67H12 N18O15 FW 1421.85 [145854-597] 2 mgMas7 is a mast cell degranulating peptide. Activates G proteins that couple to 5 mgphospolipase C.

M0273 Mas8 0.5 mgC70H131N21O15 FW 1506.96 1 mg

2.5 mg

HN

CH3

HCl

H-Arg-Thr-Lys-Arg-Ser-Gly-Ser-

Val-Tyr-Glu-Pro-Leu-Lys-Ile-OH

H- le-Asn-Leu-Lys-Ala-Leu-Ala-

Ala-Leu-Ala-Lys-Ala-Leu-Leu-

NH2

H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-

Ala-Leu-Ala-Lys-Arg-Leu-Leu-

NH2


M0275 Mas17 1 mgC70H132N20O15 FW 1493.96 [145854-61-1] 2 mg

5 mg

M0374 Masitinib 5 mgC28H30N6OS FW 498.64 [790299-79-5] 25 mgA multi-targeted protein tyrosine kinase inhibitor with potential antineoplastic activity.

Dubreuil P, Letard S, Ciufolini M, Gros L, Humbert M, et al. (2009) Masitinib (AB1010), a Potent and

Selective Tyrosine Kinase Inhibitor Targeting KIT. PLoS ONE 4(9): e7258. doi:10.1371/journal.pone.0007258

M0276 Mast Cell Degranulating Peptide 0.5 mgC110H188N40O24S4 FW 2583.28 [32908-73-9] 1 mgA highly potent convulsant polypeptide from the Mamba snake. 2.5 mgStansfeld CE, Marsh SJ, Parcej DN, Brown DA. Neuroscience 23(3) 893-902 (1987)

M0172 Mastoparan 1 mgC70H131N19O15 FW 1478.92 [72093-21-1]A tetradecapeptide from wasp venom that activates G(i) and mast cells, in addition to

inhibiting Ca2+-ATPase. It has also been shown to induce apoptosis in cultured cerebellar granule neurons.Chahdi A, Choi WS, Kim YM et al. J Biol Chem. 278:12039-45 (2003).

Longland CL, Mezna M, Michelangeli F. J Biol Chem. 274 :14799-805 (1999).

Lin SZ, Yan GM, Koch KE et al. Brain Res. 771:184-95 (1997).

M0173 Mastoparan X 1 mgC73H126N20O15S FW 1556.01 [72093-22-2] 2 mgA peptidic toxin known to induce transbilayer movement of ions. 5 mgMatsuzaki K, Yoneyama S, Murase O, Miyajima K. Biochemistry 35(25); 8450-8456 (1996)

M0278 Matrine 100 mgC15H24N2O FW 248.37 [519-02-8] 500 mgAn alkaloid. It has antiulcerogenic activity against stress ulcer in rat. It 1 g depresses both glutamate-induced responses and neurally evoked excitatory junctional potentials.Ishida M, Shinozaki H. Br J Pharmacol. 82:523-31 (1984).

Yamazaki M, Arai A. J Pharmacobiodyn. 8:513-7 (1985).

M1605 Mebendazol 5 gC16H13N3O3 FW 295.29 [31432-39-7] 25 gAn anthelmintic drug.

Apt W. Rev Med Chil. 118:1021-7 (1990).

M1708 Mecamylamine Hydrochloride 5 mgC11H21N.HCl FW 203.75 [826-39-1] 25 mgNon-competitive nicotinic acetylcholine receptor antagonist; preferentially 100 mgblocks nicotinic receptors at autonomic ganglia. Able to cross the blood brain barrier.Rodgers, R. J. Psychopharmacology (Berlin, Germany) (1979), 66(1), 93-8.

M1613 Medroxyprogesterone 17-Acetate 500 mgC24H34O4 FW 386.52 [71-58-9] 1 gAn angiostatic steroid, found to inhibit vascularization, collagenolysis, 5 gtumor growth and plasmin generation.Blei F, Wilson EL, Mignatti P, Rifkin DB. J Cellu Physio. 155:568-78 (1993).

N

CH3

CH2CO2H

CH3O

C

ClO

O

OOH

HO

OCH3

OH

OO

H

H3COH

O

H

O

O

O

O

HO H

H

CH3

CH3

CH3

H

OO

H

H3COH

H

O

H

O

O

O

OH

O

HO H

H

CH3

CH3

CH3

H

O

O

OCH

H3C

H3C

O

O

O

H

CH3

H

HH

O

O

O

CH3

CH3

CH3

H OH

H

O

HO

H

OH

HOH

H3C NH

HN CH3

O

O

OH

OH

OOH OH

OH

OH

OHOOH

H3C

H3C

OO

O

CH3

CH3

H

CH3

CH3 CH3

OH

H

OH

H3C

H3C

O O

CH3 CH3 CH3

O

OH

Ca2

O

OH

OHHO

HO

S

O

OOH

HO

OH

OH

OH

HN

CH2COOHC

COOH

CH3

H2C

HOO

H H

H

OHH

OH

CH2OH

H

O

H

H CH2OH

HOH OHO

CH2OH

N

OH

OH

OH

OH

COOH

S (CH2)6 NCS

S (CH2)7 NCS

S (CH2)8 NCS

S (CH2)9 NCS

O

OH

OH

OCH3

OOH

HO

OOC C

OH

H

C

H

OH

C

OH

H

C

OH

H

COO

Ca

O

O

OH

OH

COCH3

OH

O

OH3C

HO

NH2.HCl

HN

O

NH

HO

OO

N N

N

N

N

OCH2

OCHCH3CH2

CH3

O

O

CH2

N

N

N

H

Cl

Cl

CF3

NO2HN

O

HO

NO2

OHO

O

OCH3

O

OH

CH3

H3C O

CH3

CH3

COOH

OH

HO

O

OH

O

OH

HO

HO

OH

OH

O

O

OH

O

OH

HO

HO

OH

O

OH

HO

HO

OH

OH

HO

O

OH

O

OH

HO

HO

O

OH

HO

OH

O

H

OH

CH3CH3 H

H

O CH3

CH3

CH3

O

OH

OH

OH

CH2O

OH

OH

OH

CH2OH

O

OH

O

OH

CH2OH

O

OH

OH

OH

CH2OH

O

O

H3C

H

CH3

CH3

H

OH

CH3CH3 H

H

O CH3

CH3

CH3

O

OH

OH

OH

CH2O

OH

OH

O

OH

O

OH

CH2OH

O

OH

OH

OH

CH2OH

O

O

H3C

H

CH3

CH3

OH

H

OH

CH3CH3 H

H

O CH3

CH3

CH3

O

OH

OH

OH

CH2O

OH

OH

O

OH

O

OH

CH2OH

O

OH

OH

OH

CH2OH

O

O

H3C

H

CH3

CH3

OH

OH

OO

OH

O

OH

CH2OH

O

OHOH

OH

CH2OH

OO

OH

OH

OH

CH2OOH

OH

O

HO

H

OH

CH3CH3 H

H

O CH3

CH3

CH3

O

OH

OH

OH

CH2

O

OH

O

OH

CH2OH

O

OH

OH

OH

CH2OH

HO

O

H3C

H

CH3

CH3

H

OH

CH3CH3 H

H

O CH3

CH3

CH3

O

OH

OH

OH

CH2HO

H3C

H

CH3

CH3

O

OH

O

OH

CH2OH

O

OH

O

OH

CH3

OH

H

OH

CH3CH3 H

H

O CH3

CH3

CH3

O

OH

OH

OH

CH2OH

HO

H3C

H

CH3

CH3O

H

O

HOOH

OH

CH2OH

H

OH

CH3CH3 H

H

HO CH3

CH3

CH3

HO

H3C

H

CH3

CH3

O

OH

O

OH

CH2OH

O

OH

O

OH

CH3

OH

HO

H3C

HO

CH3 CH3

OH

H

H CH3

H

CH3

OO

OH

OH

OH

HO

H

OH

CH3CH3 H

H

HO CH3

CH3

CH3

HO

H3C

H

CH3

CH3OH

H

OH

CH3CH3 H

H

HO CH3

CH3

CH3

HO

H3C

H

CH3

CH3

O

O

O

O

O

OH

O

OH

OH

OH

OH

O

OHOH

OH

H

OH

CH3CH3 H

H

O CH3

CH3

CH3

HO

H3C

H

CH3

CH3O

O

HO

HO

HO

OH

O

O

OH

OH

CH2OH

O

HOHO

H

OH

CH3CH3 H

H

HO

H3C

H

CH3

CH3

O

H

OH

CH3CH3 H

H

HO

CH3

H

CH3

CH3OH

O

H

OH

CH3CH3 H

H

HO

CH3

H

CH3

CH3

O

O

OH

O

OH

O

OH

CH2OH

O

OH

O

OH

CH3

OH

O

OH

OH

CH2HO

O OH

OCH3

OH

OH

HO

HO

O

NH2

N

N

O CH3O

Cl

O

OH

OH

OOH

HO

O

HOH2C

HO

HO

NH2

OH

HCl

HO

HO

H3C CH3

H O

OH

CH3

OH

OH

CH3H3C

HO

OH

H3C

N

OH

NH

O

N

CH3

H3CO

H3CO

O

CH3

O

O O

O

O

O

O

O

O

CH3

H

CH3

RH

CH3

H3C

OH

H

HO

H3C

OCH3

H

H3C

OCH3

H

H

H

OH

CH3

B1a R=CH2CH3

B1B R=CH3

O

N

SCH3

OH

OH

OH

CH

CH

CH3

NH

HO

O

CH3

H3C

N

N

NH

SNH

NH

H3C

O

O OO

O O

COONa

OH

OH

O

CH2OH

HN

HO

O OH

CH2OH

HO

O O

COONa

OH

OH

HO

O

CH3

O

HN CH3

On-1

N

CH3

HNS

NH2

Cl

OOO

II

I

NHO

O

OHN OH

HN OH

OH

OH

OH3C

OH

HO

HO

HN CH3

OH

CH3HCl

O

OOH

HO

OH

O

O

H

CH3

NH

O

CH3

O

H3CO

H3C

H3C

H3CO

OCONH2

H3CO

O

O

N

O

O

OH

OO

OHO

NC

N

CN

N

N

O

O

NH2

O

OH

HO

O

H2N

HO

HO

H2N

OH

H2N

OH HO

O

O

NH2

O

OH

HO

O

H2N

HO

HO

H2N

OH

H2N

NH2 HO

O

OOH

O

OH

O

CH2OH

OH

OH

OH

O

O OCH3

HOH2CO

H

HO

OHOH2C

HOHO OH

HN

CH3

HCl

H3C

COOHCH3CH3

HOCH3

HO

HO

CH3

CH3

OH

NH2

NH2

HO

O

CH3

CH3

CH3

H3C

H3C

H3C

CH3

CH3

H3C

H3C

Cl

Cl

NH

N

O

(CH2)4CH3

(CH2)4CH3

OO

Na

O

Cl N

HO

N

CH3

CH3

O

HCl

N

N

COOH

Cl Cl

HN N

O

Cl

NO

N

N

H3CO

F

F

OCH3

OCH3

2HCl

N

HN

O

Cl

CH3

ClHCl

NH

N

COOH

COOHO

2H2O

NH2

S S

CO2H

CO2H

O

O OH

H

OH3C

CH3

O

OO

OH

HO

OH

CH2OH

O

O

O

O

CH3

O

CH3O

OO

O

H3C CH3

NHN

OHN

N

NC

NC

H3C

O

H3COH

C CH

N

N N

O

CO2HF

.HCl . H2O

O

H3C

H

CH3

N

N

O COOHCl

.2HCl

N

N

S

H

NHH3C

O

O

O

N

OH

OCH3

H3C

OCH3

OH

OCH3

CH2OH

CH2OH

O

HO

HOH2C

H3CHN

O COOH

S

NH

HOCH3

O

H3C

CH3

OH

O

O

O

HO

N

N

CH3

O

N

N

Cl

Cl

O

CH3

O

HO

CH3

CH3

H3C

HO

OH

CH3

H

H

CH3

H3C

O

HN

HN

O

Br

OO

OCH3

H-Phe-Leu-Pro-His-Val-Phe-Ala-

Glu-Leu-Ser-Asp-Arg-Lys-Gly-

Phe-Val-Gln-Gly-Asn-Gly-Ala-Val-

Glu-Ala-Leu-His-Asp-Phe-Tyr-

Pro-Asp-Trp-Met-Asp-Phe-NH2

H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-

Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-

Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-

Gln-Asp-Ile-Met-Asn-Arg-Gln-Gln-

Gly-Glu-Arg-Asn-Gln-Glu-Gln-Gly-

Ala-Lys-Val-Arg-Leu-NH2

H-His-Ala-Asp-Ala-Ile-Phe-Thr-Ser-

Ser-Tyr-Arg-Arg-Ile-Leu-Gly-Gln-

Leu-Tyr-Ala-Arg-Lys-Leu-Leu-His-

Glu-Ile-Met-Asn-Arg-Gln-Gln-Gly-

Glu-Arg-Asn-Gln-Glu-Gln-Arg-Ser-

Arg-Phe-Asn-OH


Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-


Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-




Asn-Ser-Tyr-Arg-Lys-Ile-Leu-Gly-


Gln-Asp-Ile-Met-Asn-Arg-Gln-Gln-

Gly-Glu-Arg-Asn-Gln-Glu-Gln-Gly-

Ala-Lys-Val-Arg-Leu-NH2

H-His-Val-Asp-Ala-Ile-Phe-Thr-

Thr-Asn-Tyr-Arg-Lys-Leu-Leu-

Ser-Gln-Leu-Tyr-Ala-Arg-Lys-

Val-Ile-Gln-Asp-Ile-Met-Asn-Lys-

Gln-Gly-Glu-Arg-Ile-Gln-Glu-

Gln-Arg-Ala-Arg-Leu-Ser-OH


Leu-Ser-Pro-Glu-His-Gln-Lys-

Ala-Gln-Gln-Arg-Lys-Glu-Ser-


Gln-Pro- Arg


Leu-Ser-Pro-Glu-His-Gln-Arg-

Val-Gln-Gln-Arg-Lys-Glu-Ser-


Gln-Pro-Arg


Asp-Glu-Met-Asn-Thr-Ile-Leu-

Asp-Asn-Leu-Ala-Ala-Arg-Asp-

Phe-Ile-Asn-Trp-Leu-Ile-Gln-

Thr-Lys-Ile-Thr-Asp-Arg-OH


Asp-Glu-Met-Asn-Thr-Ile-Leu-

Asp-Asn-Leu-Ala-Thr-Arg-Asp-

Phe-Ile-Asn-Trp-Leu-Ile-Gln-

Thr-Lys-Ile-Thr-Asp-OH


Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-

Asn-Leu-Ala-Thr-Arg-Asp-Phe-Ile-

Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-

Thr-Asp-OH




Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-

OH

H-Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-

Tyr-Ala-Ala-Cys-Thr-Gly-Cys-OH


H-Gly-Ala-Tyr-OH

H-Gly-Phe-Arg-OH

H-Gly-Pro-Arg-OH

H-Gly-Gln-OH

H-Thr-Pro-Pro-Ala-Tyr-Arg-Pro-

Pro-Asn-Ala-Pro-Ile-Leu-OH

H-His-Ser-Asp-Ala-Ile-Phe-Thr-

Glu-Glu-Tyr-Ser-Lys-Leu-Leu-

Ala-Lys-Leu-Ala-Leu-Gln-Lys-

Tyr-Leu-Ala-Ser-Ile-Leu-Gly-Ser-

Arg-Thr-Ser-Pro-Pro-Pro-NH2



Lys-Leu-Ala-Leu-Gln-Lys-Tyr-Leu-

Glu-Ser-Ile-Leu-Gly-Ser-Ser-Thr-

Ser-Pro-Arg-Pro-Pro-Ser-Ser-OH



Lys-Leu-Ala-Leu-Gln-Lys-Tyr-

Leu-Glu-Ser-Ile-Leu-Gly-Ser-Ser-

Thr-Ser-Pro-Arg-Pro-Pro-Ser-OH

His-His-His-His-His-His

Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-

Leu-Arg-Pro-NHEt

His-Cys-Lys-Phe-Trp-Trp

Ser-Leu-Tyr-Asn-Thr-Val-Ala-

Thr-Leu

Ac-Ala-Arg-Val-Leu-Ala-Glu-

Ala-NH2

C67H124N18O15 Mol.Wt.: 1421.85H-Ile-Asn-Leu-Lys-Ala-Leu-

Ala-Ala-Leu-Ala-Lys-Ala-

Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2

C67H124N18O15 Mol.Wt.: 1421.85

H-Ile-Asn-Leu-Lys-Ala-Leu-


Leu-Leu-NH2 C67H124N18O15 Mol.Wt.: 1421.85H-Ile-Asn-Leu-Lys-Ala-Leu-


Leu-Leu-NH2



Leu-Leu-NH2



Leu-Leu-NH2

C67H124N18O15 Mol.Wt.: 1421.85

H-Ile-Asn-Leu-Lys-Ala-Leu-


Leu-Leu-NH2

C110H188N40O24S4 Mol.Wt.: 2583.27 C110H188N40O24S4 Mol.Wt.: 2583.27 C110H188N40O24S4 Mol.Wt.: 2583.27 C110H188N40O24S4 Mol.Wt.: 2583.27 C110H188N40O24S4 Mol.Wt.: 2583.27

NH

O

OH

HO

NH

NH2

O

H3C

S N

C

S

H-Ile-Leu-Pro-Trp-Lys-Trp-Pro-

Trp-Trp-Pro-Trp-Arg-Arg-NH2

H-Thr-Ser-Leu-Pro-Val-Gln-

Asp-Ser-Ser-Ser-Val-Pro-OH

H-Asp-Met-Ser-Ser-Asp-Leu-

Glu-Arg-Asp-His-Arg-Pro-His-

Val-Ser-Met-Pro-Gln-Asn-Ala-

Asn-OH


NH2

H-Leu-Arg-Arg-Ala-Ser-Leu-

Gly-OH

Met-Arg-Phe-Phe-Val

H-Lys-Gly-Asp-Ser-OH

H-Leu-Pro-Pro-Val-Ala-Ala-

Ser-Ser-Leu-Arg-Asn-Asp-OH

H-Ile-Ala-Arg-Arg-His-Pro-Tyr-

Phe-Leu-OH

H-Lys-Arg-Gln-His-Pro-Gly-OH

H-Tyr-Arg-OH

Ac-Leu-Glu-His-Asp-pNA

Val-Pro-Ile-Gln-Lys-Val-Gln-

Asp-Asp-Thr-Lys-Thr-Leu-Ile-

Lys-Thr-Ile-Val-Thr-Arg-Ile-

Asn-Asp-Ile-Ser-His-Thr-Gln-

Ser-Val-Ser-Ser-Lys-Gln-Lys

H-Ser-Cys-Ser-Leu-Pro-Gln-

Thr-Ser-Gly-Leu-Gln-Lys-Pro-

Glu-Ser-OH

H-Asp-Pro-Ala-Phe-Asn-Ser-Trp-

Gly-NH2

H-Gly-Ala-Ser-Phe-Tyr-Ser-Trp-

Gly-NH2

pGlu-Asp-Val-Asp-His-Val-Phe-

Leu-Arg-Phe-NH2

pGlu-His-Trp-Ser-Tyr-D-Leu-

Leu-Arg-Pro-NHEt

pGlu-Gly-Met-Ile-Gly-Thr-Leu-

Thr-Ser-Lys-Arg-Ile-Lys-Gln-NH2

Tyr-Gly-Gly-Phe

pGlu-Gln-Trp-Ala-Val-Gly-His-

Phe-Met-NH2


Arg-Pro-Gly-NH2


Gln-Pro-Gly-NH2

pGlu-His-Trp-Ser-Tyr-Gly-Trp-

Leu-Pro-Gly-NH2

pGlu-His-Trp-Ser-His-Asp-Trp-

Lys-Pro-Gly-NH2

Lys(Boc)-Leu-Lys(Boc)-OBzl


Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-

Gly-Phe-Ser-Pro-Phe-Arg-NH2

C[Cys-Tyr-Phe-Gln-Asn-Cys]-Pro-

Lys-Gly-NH2


Gly-Tyr-Leu-Leu-Gly-Pro-Pro-

Pro-Ala-Leu-Ala-Leu-Ala-NH2

Phe-Leu-Trp-Gly-Pro-Arg-Ala-

Leu-Val


Ser-Ala-Lys-Lys-Phe-Gly-Lys-


Asn-Ser-OH


Ser-Ala-Gly-Lys-Phe-Gly-Lys-


Lys-Ser-OH

H-Arg-Thr-Lys-Arg-Ser-Gly-Ser-

Val-Tyr-Glu-Pro-Leu-Lys-Ile-OH


Ala-Leu-Ala-Lys-Ala-Leu-Leu-

NH2


Ala-Leu-Ala-Lys-Arg-Leu-Leu-

NH2

H-Ile-Asn-Leu-Lys-Ala-Lys-Ala-

Ala-Leu-Ala-Lys-Lys-Leu-Leu-

NH2

H-Ile-Lys-Cys-Asn-Cys-Lys-Arg-

His-Val-Ile-Lys-Pro-His-Ile-Cys-

Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2


Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-

Leu-Ala-Lys-Lys-Ile-Leu-NH2

H-Ile-Asn-Trp-Lys-Gly-Ile-Ala-

Ala-Met-Ala-Lys-Lys-Leu-Leu-

NH2


Gly-Tyr-Leu-Leu-Gly-Pro-Gln-

Gln-Phe-Phe-Gly-Leu-Met-NH2

pGlu-Gly-Pro-Trp-Leu-Glu-Glu-

Glu-Glu-Glu-Ala-Tyr-Gly-Trp-

Met-Asp-Phe-NH2

pGlu-Arg-Pro-Pro-Met-Glu-Glu-

Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-

Asp-Phe-NH2

H-D-Ala-D-2-Nal-Ala-Trp-D-

Phe-Lys-NH2

H-His-D-Trp-Ala-Trp-D-Phe-Lys-

NH2

His-Ser-Gln-Gly-Thr-Phe-Thr-

Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-

Asp-Ser-Arg-Arg-Ala-Gln-Asp-

Phe-Val-Gln-Trp-Leu-Met-Asn-

Thr

H-Ala-Gln-Asp-Phe-Val-Gln-Trp-

Leu-Met-Asn-Thr-OH




Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

Glp-His-Tyr-Ser-Tyr-Gly-Leu-

Arg-Pro-Gly-NH2

Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-

Leu-Arg-Pro-AzaGly-NH2

H-Arg-Val-Thr-Ala-Ile-Glu-Lys-

Tyr-Leu-Gln-Asp-Gln-Ala-Arg-

Leu-Asn-Ser-Trp-Gly-Cys-Ala-

Phe-Arg-Gln-Val-Cys-OH


H-Phe-Gly-Phe-Leu-Pro-Ile-Tyr-

Arg-Arg-Pro-Ala-Ser-NH2

H-Tyr-Pro-Tyr-Asp-Val-Pro-Asp-

Tyr-Ala-OH

H-Trp-Gln-Pro-Pro-Arg-Ala-Arg-

Ile-OH

lle-lle-Ser-Ala-Val-Val-Gly-

lle-Leu

Leu-Leu-Asp-Ile-Asp-Glu-Thr-

Glu-Tyr

H-Asp-Ser-His-Ala-Lys-Arg-

His-His-Gly-Tyr-Lys-Arg-Lys-

Phe-His-Glu-Lys-His-His-Ser-

His-Arg-Gly-Tyr-OH

H-Ile-Leu-Lys-Glu-Pro-Val-His-

Gly-Val-OH

Trp-Gly

Thr-Asp-Thr-Ser-His-His-Asp-

Gln-Asp-His-Pro-Thr-Phe-Asn

Met-Ala-Pro-Arg-Gly-Phe-Ser-

Cys-Leu-Leu-Leu-Leu-Thr-Ser-

Glu-Ile-Asp-Leu-Pro-Val-Lys-

Arg-Arg-Ala


NH2

SO

NH2.HCl

N

O

O

O

O

O

OH

OH

H

O

O

N

O

H3CO

OH

CH3

HBr

COOH

OHHO

OH

H-Tyr-Ala-Glu-Gly-Thr-Phe-Ile-

Ser-Asp-Tyr-Ser-Ile-Ala-Met-

Asp-Lys-Ile-His-Gln-Gln-Asp-

Phe-Val-Asn-Trp-Leu-Leu-Ala-

Gln-Lys-Gly-Lys-Lys-Asn-Asp-

Trp-Lys-His-Asn-Ile-Thr-Gln-OH

Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-

Thr-Val-Leu-Thr-Lys-Met-Tyr-Pro-


His-Leu-Met-NH2

Ala-Pro-Val-Ser-Val-Gly-Gly-Gly-

Thr-Val-Leu-Ala-Lys-Met-Tyr-Pro-


His-Leu-Met-NH2

HO

OHO

CH3

Tyr-Ala-Asp-Ala-lle-Phe-Thr-Asn-

Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-

Leu-Ser-Ala-Arg-Lys-Leu-Leu-

Gln-Asp-lle-Met-Ser-Arg-Gln-Gln-



N

S

N NHO

O

.2HCl

His-Ser-Asp-Ala-lle-Phe-Thr-Gln-

Gln-Tyr-Ser-Lys-Leu-Leu-Ala-Lys-

Leu-Ala-Leu-Gln-Lys-Tyr-Leu-Ala-

Ser-lle-Leu-Gly-Ser-Arg-Thr-Ser-

Pro-Pro-Pro-NH2

Tyr-Pro-Trp-Thr-Gln-Arg-Phe

Thr-Pro-Pro-Ala-Tyr-Arg-Pro-Pro-

Asn-Ala-Pro-lle-Leu

His-D-2-Me-Trp-Ala-Trp-D-Phe-

Lys-NH2

O

H3C

O

H3C

OH

H3C

O

H3C

H3C

H3C

OH

H3C

O

H3C

O

H3C

CH3

O

O NH

S

O

HO

HO

CH3

O

O

CH3

HN

CH3

CH3

CH3

HCl

O

N

HN

NH

O

OCH3

N

N

O

HH

H H

HN

Cl

F

HO

O

H3C

N

O

O

NH2

HH3C

N

N

HN Cl

O

F

O

NHS

O

O

H3C

H2O

SOH

O

O

2

N

NN

Cl

Cl

H2N NH2

N

HN

O

O

N

O

F

N N

NH

O

O

CH3

HOO

O(CH2)5CH3

H

NN

HN

O

O

H3C

OHO

HO

H

NN

HN

O

O

H3C

OHO

H3CO

H

NN

OH3C

H3C

H3C

H3C

OH O

OOH

H3CO

H3CO

OCH3

CH3

COCH3

OCH3

O

OH

NH3C

CH3

CH3

O

OH

CH3

NH3C

CH3

NN

H3CO

HN

N

CH3

N

N

O

O

CH2OH

CH3

SSOH

O

OOO

CH3OH

H

O

OH

O

O

CH3

H3C CH3

HO

O

FOH

FHO

N

N

NH2

O

HCl

OH

OH

O

O

OC(CH2)18CH3

OH

O

O

OC(CH2)6CH2

OH

O

CH2

(CH2)4CH3

O

OH

OC(CH2)6CH2

O

CH2(CH2)6CH3

OC(CH2)14CH3

OH

O

O

O

OH

OC(CH2)16CH3

O

OHO

OH

O

OH

OH

OH

OOH

OH

OH


M1622 Mefenamic acid 10 gC15H15NO2 FW 241.29 [61-68-7] 50 gA NSAID that has antiproliferative activity against human colon cancer cells. 100 gHixson LJ, Alberts DS, Krutzsch M et al. Cancer Epidem. Bio Prev. 3:433-438 (1994).

M1626 Megestrol Acetate 250 mgC24H32O4 FW 384.51 [595-33-5] 1 gOrally active progestogen used in the treatment of advanced breast cancer. 5 gSbrams JS, Gutheil J, Aisner J. Oncology. 49 Suppl 2:12-7 (1992).

Sedlacek SM. Semin Oncol. 15:3-13 (1988).

M1826 Meglumine 100 gN-Methyl-D-glucamine 500 gC7H7NO5 FW 195.21 [6284-40-8] 1 kgAn antiprotozoal (leischmaniasis) agent.

Chapman WL Jr, Hanson WL, Alving CR et al. Am J Vet Res. 45:1028-30 (1984).

M1646 Melanin Concentrating Hormone,human,mouse,rat 0.5 mgMCH, human, mouse, rat 1 mgC105H160N30O26S4 FW 2386.8 2.5 mgAn orexigenic neuropeptide. It has been found to increase circulating adrenocorticotropic hormone, hippocampal nitric oxide and cGMP levels.Kennedy AR, Todd JF, Dhillo WS et al. J Neuroendocrinol. 15:268-72 (2003).

Varas M, Perez M, Monzon ME et al. Peptides. 23:2213-21 (2002).

M1647 Melanin Concentrating Hormone, salmon 0.5 mgMCH, salmon 1 mgC89H137N27O24S4 FW 2097.9 2.5 mg

M7528 α-Melanocyte stimulating hormone 1 mgC77H109N21O19S FW 1664.9 [581-05-5]An endogenous peptide that exerts an anti-inflammatory action by inhibtion of nitric oxide synthase-2.

Gupta AK, Diaz RA, Higham S et al. Kidney International. 57:2239-2248 (2000).

M7529 β-Melanocyte stimulating hormone, human 1 mgC118H174N34O35S FW 2660.9 [17908-57-5]The key ligand acting on melanocortin-4 receptors that play a part in the sensation of hunger.Harrold JA, Widdowson PS, Williams G. Peptides. 24:397-405 (2003).

M7530 [Nle4, D-Phe7] a-Melanocyte stimulating hormone 5 mgNDP-MSH, Melanotan I 25 mgC78H111N21O19 FW 1646.9

M7531 γ 1-Melanocyte stimulating hormone 1 mgC72H97N21O14S FW 1512.8

M7532 γ 3-Melanocyte stimulating hormone 1 mgC126H188N44O37S FW 2943.2

Asp-Phe-Asp-Met-Leu-Arg-

Cys-Met-Leu-Gly-Arg-Val-

Tyr-Arg-Pro-Cys-Trp-Gln-Val

(Cys7-Cys16)

Asp-Thr-Met-Arg-Cys-Met-Val-

Gly-Arg-Val-Tyr-Arg-Pro-Cys-

Trp-Glu-Val (Cys5-Cys14)

Ala-Glu-Lys-Lys-Asp-Glu-Gly-

Pro-Tyr-Arg-Met-Glu-His-Phe-

Arg-Trp-Gly-Ser-Pro-Pro-Lys-

Asp

Ac-Ser-Tyr-Ser-Met-Glu-His-

Phe-Arg-Trp-Gly-Lys-Pro-Val-

NH2

Ac-Ser-Tyr-Ser-Nle-Glu-His-D-

Phe-Arg-Trp-Gly-Lys-Pro-Val-

NH2

Tyr-Val-Met-Gly-His-Phe-Arg-

Trp-Asp-Arg-Phe-NH2

Tyr-Val-Met-Gly-His-Phe-Arg-

Trp-Asp-Arg-Phe-Gly-Arg-Arg-

Asn-Gly-Ser-Ser-Ser-Ser-Gly-

Val-Gly-Gly-Ala-Ala-Gln

HO

HN

CH3

OH

OH OH

OH

O

CH3

CH3

CH3

C

CH3

OCOCH3

O

HN

CH3

CH3

COOH


M1649 Melanoma-associated antigen peptide 1 mgMART-1(27-35), human 2 mgC37H67N9O11 FW 814.0 5 mg

M1648 Melanostatin, frog 0.5 mgC189H285N53O57S1 FW 4243.76 1 mgAn alpha melanocyte stimulating horomone isolated from frogs brains. 2.5 mgValentijin JA, Vaudry H, Kloas W, Cazin L J Physiol 1175: 185-195 (1994).

M1650 Melanotan II 5 mgMT-II 10 mgC50H69N15O9 FW 1024.2 [121062-08-6] 25 mgA non selective melanocortin receptor agonist. It has been shown to increase insulin sensitivity

and exert neuroprotective effects in rat.

Banno R, Arima H, Sato I et al. Peptides. 25:1279-86 (2004).

Ter Laak MP, Brakkee JH, Adan RA et al. Eur J Pharmacol. 462:179-83 (2003).

M1745 Melatonin 1 gN-acetyl-5-methoxytryptamine 5 gC13H16N2O2 FW 232.27 m.p. 116-1180C [73-31-4] 10 gA hormone of the pineal gland, has antiproliferative and chemopreventive activity. It induces apoptosis.

Eck-Enriquez K, Kiefer TL, Spriggs LL, Hill SM. Breast Cancer Res Treat. 61:229-39 (2000).

Teplitzky SR, Kiefer TL, Cheng Q et al. Cancer Lett. 168:155-63 (2001).

Kothari A, Borges A, Kothari L. Eur J Cancer Prev. 4:497-500 (1995).

M1744 Melittin 0.5 mgMellitin 1 mgC131H229N39O31 FW 2846.5 [20449-79-0] 2.5 mgA bee venom peptide that has been shown to inhibit viral infection development.

Lazarev VN, Stipkovits L, Biro J et al. Microbes Infect. 6:536-541 (2004).

M1644 Meloxicam 100 mgMetacam 500 mgC14H13N3O4S2 FW 351.41 [71125-38-7] 1 gA non-steroidal anti-inflammatory agent with high inhibitory action against the

inducible form of cyclo-oxygenase (COX-2). Found to inhibit the growth of

colorectal cancer cells in vitro.Noble S, Balfour JA. Drugs. 51:424-430 (1996).

Goldman AP, Williams CS, Sheng H et al. Carcinogenesis 19:2195-2199 (1998).

M1749 Memantine hydrochloride 25 mgC12H21N.HCl FW 215.77 [41100-52-1] 100 mgA non-competitive N-methyl-D-aspartate receptor antagonist.

Rammes G, Rupprecht R, Ferrari U et al. Neurosci. Letters. 306:81-84 (2001).

M1752 Men 10376 0.5 mgC57H68N12O10 FW 1081.25 1 mgAn NK2 antagonist. 2.5 mgMa QP, Woolf CJ. J Physiol 486: 769-777 (1995).

M1669 6-Mercaptopurine Monohydrate 1 g6-Purinethiol 5 gC5H4N4S.H2O FW 170.20 m.p. 313-3140C [6112-76-1] 25 gAn anti-inflammatory agent that has antitumor activity.Kela U, Vijayvargiya R. Biochem J. 193:799-803 (1981).

Bokkerink JP, Stet EH, De Abreu RA et al. Biochem Pharmacol. 45:1455-63 (1993).

N

NNH

N

SH

NH2

H3C

CH3

.HCl

Ala-Ala-Gly-Ile-Gly-Ile-Leu-

Thr-Val

H-Tyr-Pro-Ser-Lys-Pro-Asp-

Asn-Pro-Gly-Glu-Asp-Ala-Pro-

Ala-Glu-Asp-Met-Ala-Lys-Tyr-

Tyr-Ser-Ala-Leu-Arg-His-Tyr-

Ile-Asn-Leu-Ile-Thr-Arg-Gln-

Arg-Tyr-NH2

Ac-Nle-Asp-His-D-Phe-Arg-

Trp-Lys-NH2

(Lactam bridge Asp2-Lys7)

Gly-Ile-Gly-Ala-Val-Leu-Lys-

Val-Leu-Thr-Thr-Gly-Leu-Pro-

Ala-Leu-Ile-Ser-Trp-Ile-Lys-

Arg-Lys-Arg-Gln-Gln-NH2

H-Asp-Tyr-D-Trp-Val-D-Trp-

DTrp-Lys-NH2

SN

CH3

NH

S

NOH O

CH3

O O

HN

H3COHN

CH3

O


M1770 Meropenem 25 mgC17H25N3O5S FW 383.46 [96036-03-2] 100 mgAn antibiotic, effective against a wide range of bacteria, that has a low 500 mgtoxicity profile and no central nervous system toxicity.Cottagnoud P. Cell Mol Life Sci. 59:1928-33 (2002).

Kayser FH, Morenzoni G, Strassle A et al. J Antimicrob Chemother. 24 Suppl A:101-12 (1989).

Mesalamine (See 5-Aminosalicylic acid)Mesalazine

M1774 MESNA (2-Mercaptoethanesulfonate sodium) 5 gC2H5O3S2

. Na FW 164.18 [19767-45-4] 10 gA uroprotective agent used in combination with cancer chemotherapeutic drugs to 25 gdecrease urotoxicity. It was found to have antitumor activity against several cell lines.

In addition, it is used as an antimucolytic agent.Brock N. Recent Results Cancer Res. 74:270-8 (1980).

Blomgren H, Hallstrom M, Hillgren H. Methods Find Exp Clin Pharmacol. 12:691-7 (1990).

Tekeres M, Horvath A, Bardosi L, Kenyeres P. Clin Ther. 4:56-60 (1981).

M2076 Metformin Hydrochloride (See page 18 for more info) 25 g1,1-Dimethylbiguanide Hydrochloride 100 gC4H11N5

.HCl FW 165.62 [1115-70-4]An oral hyperglycemic drug utilized in the treatment of type 2 diabetes.

Decreases hepatitc glucose production, decreases intestinal absoption and increases insulin sensisivity. Tucker, G. T. British Journal of Clinical Pharmacology (1981), 12(2), 235-46.

M1976 Methimazole 10 gC4H6N2S FW 114.17 [60-56-0] 25 gAntithyroid compound used to treat Graves' hyperthyroidism. It was found to have antioxidant

property. It inhibits activation of the IFN-g-induced Janus kinase (JAK)/STAT signaling pathway

in FRTL-5 thyroid cells, which may account for its immunomodulatory effects.Kim H, Lee TH, Hwang YS et al. Mol. Pharm. 60:972-980 (2001).

M1676 Methotrexate 10 mgC20H22N8O5 FW 454.44 [59-05-2] 50 mgAntiinflammatory drug also used as antineoplastic agent. Inhibits dihydrofolate 100 mg reductase. 500 mgEckardt, JR Anticancer Drugs. 7 Suppl 2:41-6 (1996).

Fleisher M. Ther Drug Monit. 15:521-6 (1993).

M1678 2-Methoxy estradiol 5 mgC19H26O3 FW 302.41 [362-07-2] 10 mgThe compound 2-Methoxy estradiol has been shown to induce cell cycle arrest in 50 mgcarcinoma cells.

Zhou, N. et al. Acta. Pharmacol. Sin. 25:1515- 1520 (2004).

M1680 5-Methoxyindole 1 gC9H9NO FW 147.17 [1006-94-6] 5 g

M1677 11-Methoxyyangonin 5 mgC16H16O5 FW 288.30 10 mgA component of kava kava extract.

NH

H3CO

N

N

N

N

NH2

NH2

N

HNHOOC

OCOOH

CH3

N

O

S

H3C

COOH

H

OH

HCH3

NH

O

N

H3C

CH3

O

OCH3

OOH3C

OH3C

HSS

O

OO Na

N

N

CH3

SH

H2N NH

NH

N

NH

CH3

CH3

HCl

O

HO

H

OH

H H


M1776 α-Methylbenzyl isothiocyanate 5 gC9H9NS FW 163.24 [32393-32-1] 10 g

M1777 R(-)-α-Methylbenzyl isothiocyanate (D) 1 gC9H9NS FW 163.24 [a]20

D -21.16(neat) [24277-44-9] 5 gChiral agent. Used for the derivatization and separation of enantiomers. 10 gGal J, Sedman AJ. J Chromatography. 314:275-282 (1984).

Gal J, Desai DM, Meyer-Lehnert S. Chirality. 2:43-51 (1990).

M1778 S(+)-α-Methylbenzyl isothiocyanate (L) 1 gC9H9NS FW 163.24 [a]20D +28.14(neat) [24277-43-8] 5 gChiral derivatizing agent. 10 g

M1560 Methyl Caffeate (See page 10 for more information) 50 mgC10H10O4 FW 194.19 m.p. 163-1650

C [3843-74-1] 100 mgInhibitor of ornithine decarboxylase and protein tyrosine kinase. 500 mgRao V, Desai, D, Kaul B et al. Chem Biol Interactions. 84:277-290 (1992).

M1565 S-Methyl-L-Cysteine-S-oxide (See page 12 for more info) 100 mgC4H9NOsS FW 151.19 [6853-87-8] 250 mgAn analogue of alliin. 1 g

M1779 Methyldopa Sesquihydrate 1 gC10H13NO.

3/2H2O FW 238.24 [41372-08-1] 5 gAn adrenergic inhibiting agent is used in antihypertensive treatment. 10 gFrohlich ED. Arch Intern Med. 140:954-9 (1980).

M1780 Methylhesperidin 5 gC29H36O15 FW 624.59 [11013-97-1] 25 gA vasodilating agent.

Kikuchi K. Hirata M. Imai Y. Aramaki Y. Jpn J Pharmacol. 16:224-5 (1966).

Chen QM, Feng GH, Chung Kuo, Yao Li. Hsueh Pao. 8:344-8 (1987).

M1877 Methylprednisolone 100 mgC22H30O5 FW 374.47 [83-43-2] 500 mgApoptosis inducer, used in the treatment of lupus nephritis. Found to inhibit 1 g human small cell lung cancer cell growth.

Wang J, Lia H, Chen X, Chung Hua et al. Chinese Journal of Internal Medicine. 36:79-82 (1997).

Yamaguchi S, Ohsaki Y, Nishigaki Y et al. Int J Oncol. 15:1185-90 (1999).

M1979 Methyl Salicylate 250 mLC8H8O3 FW 152.15 [119-36-8] 500 mLAn anticoagulant in acts by interruption of the vitamin K1-epoxide cycle. 1 LPark BK, Leck JB. J Pharm Pharmacol. 33:25-8 (1981).

CCH3

HO

CH3

O

OH

CH3

O

CH2OH

COOH

H2N CH3

HO

HO

OH

OCH3

O

O

HO

OO O

O

O

O

CH3

CH3

CH3

HO

OH

HOOH

OH

HO

O

3/2H2O

H

H C

O

OCH3

HO

HO

S OH

O

NH2O

C

NCS

H3C H

C

H

H3C NCS

CHNCS

CH3


M1875 S-(N-Methylsulfinylbutylthiocarbamoyl)-glutathione 5 mg(See page 8 for more information) 10 mgC16H28N4O7S3 FW 484.61 25 mgSulforaphane glutathione conjugate

M1975 S-(N-Methylthiocarbamoyl)-L-cysteine 10 mgC5H10N2O2S2 FW 194.28 25 mgA cysteine conjugate of benzyl isothiocyanate. 100 mg

M1679 Methysticin 5 mgC15H14O5 FW 274.27 [495-85-2] 10 mgOne of the main components in kava kava extract. It has anxiolytic effect and neuroprotective property.Smith KK, Dharmaratne HR, Feltenstein MW. Psychopharmacologia. 155:86-90 (2001).

Backhauss C, Krieglstein J. Eur J Pharmacol. 215:265-9 (1992).

M1879 Metoprolol Tartrate 5 g(C15H25NO3)2

.C4H6O6 FW 684.82 [56392-17-7] 25 gb1-Adrenergic blocker.

Prakash A, Markham A. Drugs. 60:647-678 (2000).

M1977 Metronidazole 5 gC6H9N3O3 FW 171.15 [443-48-1] 25 gA nitroimidazole antibiotic that has activity against protozoans and most 100 g Gram-negative and Gram-positive anaerobic bacteria. It is a potential radiosensitizer

for cancer treatment.

Freeman CD, Klutman NE, Lamp KC. Drugs. 54:679-708 (1997).

Acharya DK. Indian J Med Sci. 48:111-6 (1994).

M1685 Mevastatin 10 mg C23H34O5 FW 390.51 m.p. 1520C [73573-88-3] 50 mg

Antitumor agent. Inhibits isoprenoid biosynthesis and reduces

plasma cholesterol levels by the inhibition of HMG-CoA reductase.

It arrests cells in the G1 phase.

Quesney-Huneeus V, Galick HA, Siperstein MD. J Biol Chem. 258:378-385 (1983).

Endo A, J. Lipid Res. 33:1569-1582 (1992).

M1687 Mevinolin (See page 26 for more information) 50 mgLovastatin (For Sodium Salt, please inquire) 100 mgC24H36O5 FW 404.54 [75330-75-5] 500 mgInhibitor of cholesterol biosynthesis rate controlling enzyme, HMG-CoA reductase.

Alberts AW, Chen J, Kuron G et al. Proc Natl Acad Sci. USA. 77:3957-3961 (1980).

Tobert JA, Bell GD, Birtwell J. et al. J Clin Investigation. 69:913-919 (1982).

M1746 Melphalan 100 mgC13H18Cl2N2O2 FW 305.20 [148-82-3] 250 mgIs a chemotherapy drug used to treat multiple myeloma and ovarian cancer. 1 gPhenylamine derivative of mechorethamine.

Palumbo, A. Blood (2008), 112(8), 3107-3114.

M2460 MGP-pNA 1 mgC18H25N5O5S FW 423.4 10 mg

H3C

CH3

OH3C

O

CH3

O

O

HO

H

H

H

CH3

OH3C

O

CH3

O

O

HO

H

H

H

N

NO2N CH3

OH

Met-Gly-Pro-pNA

O

O

OHHN

2

HO

O

OH

OH

OH

O

O NH

OH

O

SNH

NH2

OH

OOHN

S

S

O

NH2

S

O

OHNH

S

OO

O

O

O

NH2

N

O

HO

Cl

Cl


M3309 Miconazole (See page 16 for more information) 1 gC18H14Cl4N2O FW 416.14 [22916-47-8] 5 gAn antifungal agent with good aromatase inhibitory activity, found 25 gto be an effective chemopreventive agent in a rat mammary cancer model.

Lubert RA, Steele VE, Etyo I et al. Int. J. Cancer 72:95-101 (1997).

M3310 Miconazole Nitrate 1 gC18H14Cl4N2O.HNO3 FW 479.15 [22832-87-7] 5 gAn antifungal agent, was found to inhibit platelet cyclooxygenase. 25 gIshikawa S, Manabe S, Wada O. Biochem Pharmacol. 35:1787-92 (1986).

Sweeny WT. Vet Med Small Anim Clin. 70:1438-40 (1975).

Microcystins (See page 31 for more information)Microcystins are cyclic hybrid non-ribosomal peptide toxins isolated from various cyanobacteria. Microcystins inhibit eukaryotic protein phosphatases PP1 and PP2a and areselectively transported to the liver resulting in acute liver failure and tumor promotion.Sold by LKT under license from the manufacturer, MARBIONC.Carmichael, W. W. et al. Toxicon (1988) 26, 971–973MacKintosh, C. et al. FEBS Lett. (1990) 264, 187–192

M3408 Microcystin LR, desmethyl 25 µgC48H72N10O12 FW 981.20 [120011-66-7]

M3410 Microcystin (N-methyl-L)R 25 µgC50H76N10O12 FW 1009.30 [169789-55-3]

Microginins (See page 31 for more information)Microginins are a class of small, linear non-ribosomal peptides isolated from various cyanobacteria, primarily Microcystis aeruginosa. The microginins act as inhibitors against zinc metalloproteases such as angiotensin-converting enzyme1 and leucine aminopeptidase.Sold by LKT under license from the manufacturer, MARBIONC.Okino, T. et al. Tetrahedron Lett. (1993) 34, 501–504Ishida, K. et al. Tetrahedron (1997) 53, 10281–10288

M3208 Microginin 527 50 µgC25H41N3O7S FW 527.67 [1135249-50-1]

M3210 Microginin 690 50 µgC34H50N4O9S FW 690.85 [958961-34-7]

M3212 Microginin 704 50 µgC35H52N4O9S FW 704.87

M3308 Microginin 527 methyl ester 50 µgC26H43N3O7S FW 541.70

O Cl

N

N

Cl

Cl

Cl

O Cl

N

N

Cl

Cl

Cl

ON

OH

O

N

HN

OH

NH2 O

O

SO

OH

O

NH2

OH

N

O

O

HN

NH

O

O

OH

OH

SOHO

NH2

OH

N

O

O

HN

NH

O

O

OH

OH

SOO

NH2

OH

N

O

O

HN

O

O

OH

SO

O

HNN

NH

NH HNHN

HN

O

OHO O

ONH

H2N

NH O

OHO

O

O

O

O

HNN

NH

NH NHN

HN

O

OHO O

ONH

H2N

NH O

OHO

O

O

O


M3312 Microginin 690 methyl ester 50 µgC35H52N4O9S FW 704.87

M3219 MIF-1 Tyr 5 mgC22H33N5O5 FW 447.54 [77133-61-0] 10 mgA brain peptide that functions as an opiate antagonist in the reduction of contraction. 25 mgZedina JE, Kastin AJ, Kersh D, Wyatt A. Life Sci. 51: 869-85 (1991).

M3220 Tyr-W-MIF-1 5 mgC27H32N6O5 FW 520.59 [44450-13-5] 10 mg

25 mg

M3321 Mifepristone 100 mgRU486 500 mgC29H35NO2 FW 429.59 [84371-65-3] 1 gA glucocorticoid receptor antagonist. It is an effective late post-coital contraceptive and inhibitor of chemical carcinogenesis.Ashok PW, Wagaarachchi PT, Flett GM, Templeton A. Hum Reprod. 16:72-75 (2001).

Rocereto TF, Saul HM, Aikins JA Jr. Paulson J. Gynecol Oncol. 77:429-32 (2000).

Kanradt MC, Mohideen N, Vaughan AT. ibid. 77:177-82 (2000).

M3344 Milrinone 10 mgC12H9N3O FW 211.22 [78415-72-2] 50 mgA selective phosphodiesterase 3 inhibitor known to effect left ventricular 100 mgrelaxation by inhibiting the breakdown of cAMP in association with an acceleration

of sarcoplasmic reticulum Ca(2+)-ATP activity and Ca(2+) uptake. It inhibits platelet aggregation and induces disaggregation.Alousi AA, Canter JM, Montenaro MJ et al. J Cardiovasc Pharmacol. 5:792-803 (1983).Yano M, Kohno M, Ohkusa T et al. Am J Physiol-Heart Circ Physiol 279:H1898-H1905 (2000).Kikura M, Kazama T, Ikeda T, Sato S. Platelets 11:446-458 (2000).

M3353 Minocycline Hydrochloride 100 mgC23H27N3O7

.HCl FW 493.94 [13614-98-7] 250 mgA tetracycline derivative with antimicrobial activity. It was found to inhibit 500 mginducible NO synthase expression and augment cyclooxygenase (COX)-2 expression

and PGE2 production. Used to treat rheumatoid arthritis. It inhibits angiogenesis.

Patel RN, Attur MG, Dave MN et al. J Immunol. 163:3459-67 (1999).

Jackson CG, Williams HJ. Drugs. 56:337-44 (1998).

Gilbertson-Beadling S, Powers EA, Stamp-Cole M et al. Cancer Chemother Pharmacol. 36:418-24 (1995).

M3453 Minoxidil 100 mgC9H15N5O FW 209.25 [38304-91-5] 500 mgA vasodilator that has alpha 2-adrenoceptor agonist activity in addition to 1 gpotassium-channel-opening activity. It was found also to have alopecia preventive property.

Meisheri KD, Cipkus LA, Taylor CJ. J Pharmacol Exp Ther. 245:751-60 (1988).

Sharma N, Mehta AA, Santani DD, Goyal RK. J Pharm Pharmacol. 49:935-7 (1997).

Hussein AM. Int J Dermatol. 34:470-3 (1995).

M3368 Mirtazapine 10 mgC17H19N3 FW 265.35 [61337-67-5] 50 mgis a bisbenzylisoquinolinium based neuromuscular blocker or muscle relaxant. 250 mgPendeville, P. E., European Journal of Anaesthesiology (2007), 24(6), 546-550.

N

NN NH2

NH2

O

HN

CH3

NO

NC

H-Tyr-Pro-Leu-Gly-NH2

H-Tyr-Pro-Trp-Gly-NH2

N

N

N

N

OH O OH O

NH2

O

OHH H

N

OH

N

CH3

H

H

HOH

CCCH3

O

NH2

OH

N

O

O

HN

NH

O

O

O

OH

SOHO


M3476 Mithramycin 1 mg C52H76O25 FW 1084.47 [18378-89-7] 5 mgA drug used in chemotherapy that inhibits RNA and protein synthesis. 10 mgRay R, Snyder R C, Thomas S, Koller C A, Miller D M J Clin Invest. 83: 2003–2007 (1989).

M3577 Mitiglinide Calcium 100 mg2(C19H24NO3)Ca FW 668.88 [145375-43-5] 250 mgMitiglinide is thought to stimulate insulin secretion by closing the 1 gATP-sensitive K(+) K(ATP) channels in pancreatic beta-cells.Sorbera, L. A., Drugs of the Future (2000), 25(10), 1034-1042.

M3377 Mitomycin C 1 mgC15H18N4O5 FW 334.33 [50-07-7] 5 mgAntineoplastic agent. It inhibits DNA synthesis and induces apoptosis. 10 mgTomasz M et al. Science. 235:1204 (1995)

Merlo GR et al. J. Cell Biol. 128:1185 (1995).

M3378 MitoPTTM 25 TestsMitochondrial Membrane Permeability Transition Detection Kit 100 Tests

M3576 Mitotane (See page 24 for more information) 100 mgC14H10Cl4 FW 320.04 [53-19-0] 500 mgAn adrenal cyto-toxic agent used to treat adrenocartical tumors. 1 gLuton JP, Cerdas S, Billaud L et. al. New England Journal of Medicine 322:1195-1201 (1999).

M3379 Mitoxantrone Dihydrochloride 50 mgC22H28N4O6

.2HCl FW 517.41 [70476-82-3] 100 mgA cytostatic anthraquinone derivative. An antitumor agent that interacts with 500 mg DNA by intercallation.

Faulds D, Balfour JA, Chrisp P, Langtry HD. Drugs 41:400 (1991).

M3584 Mivacurium 25 mgC56H80N2O14Cl2 FW 1100.18 [106861-44-3] 100 mgA bisbenzylisoquinolinium based neuromuscular blocker or muscle relaxant 500 mgKanyamibwa,D. Methods and Findings in Experimental and Clinical Pharmacology(2008),30(3),187-191.

M3598 Mizoribine Hydrobromide 10 mgC9H14BrN3O6 FW 340.13 [50924-49-7] 25 mgIs an immunosuppressant drug. First isolated from the mold Eupenicillium 100 mgbrefeldimium antibiotic and cytotoxic effectsNakajo, A. Journal of the American Society of Nephrology (2007), 18(9), 2554-2564.

M5727 Moguisteine 100 mgC16H21NO5S FW 339.41 [119637-67-1] 250 mgAn anti-tussive with similar properties to codeine. 1 gMorita, K. European Journal of Pharmacology (2000), 395(2), 161-164.

M5746 Molsidomine 500 mgC9H14N4O4 FW 242.23 [25717-80-0] 1 gAn orally active vasodilator that requires hepatic metabolism for activity.

Molla A et al. J. Virol. 67:4688 (1993).

OOHOH

H3C

O

O

OH

CH3

OH

OCH3

H

O

O

O

O

O O

H3C

OH

H3C

OH

CH3

OH

OHH3C

O

HO

O

O

CH3

OH

OH

Cl

Cl

Cl

Cl

O

N

N

OH3C

O

NO

N

N

OMe

MeO

MeO

O

O

O

O N

OMe

OMe

OMe

OMe

OMe

O N

HO OH

HO

N

OH

O

NH2

HBr

S

N

O

O

EtO

O

OMe

NHCH2CH2NHCH2CH2OH

NHCH2CH2NHCH2CH2OH

O

O

OH

OH

N

OO O

H

H

Ca2+

O

O

N

NH2

H3C

CH2OCNH2

NH

OCH3

H

H

O


M5752 Monastrol 1 mgC14H16N2O3S FW 292.35 [254753-54-3] 5 mgA cell-permeable small molecule inhibitor of the mitotic kinesin Eg5. It arrests

cells in mitosis with monoastral spindles.

Kapoor TM, Mayer TU, Coughlin ML et al. J Cell Biol. 150:975-88 (2000).

Leizerman I, Avunie-Masala R, Elkabets M et al. Cell Mol Life Sci. 61:2060-70 (2004).

M5753 Monensin Sodium Salt 500 mgC36H61O11

.Na FW 692.86 [22373-78-0] 1 gA Na+/H+ exchanger found to induce apoptosis in HL-60 cells. 5 gZhu WH, Loh TT. Biochem Biophys Acta. 1269:122-8 (1995).

M5853 Moniliformin 1 mgC4H2O3 FW 98.06 [31876-38-7]Is a mycotoxin formed in many cereals.

Vestoi, M. Critical Reviews in Food Science and Nutrition (2008), 48(1), 21-49.

M5756 Montelukast Sodium 10 mgC35H36ClNO3S.Na FW 609.17 [151767-02-1] 25 mgA cysteinyl leukotriene receptor antagonist with anti-inflammatory effects. 100 mg In rat colitis it has been shown to increase prostaglandin E(2) production and decrease

the cyclogenase-2 protein expression.

Holma R, Salmenpera P, Riutta A et al. Eur J Pharmacol. 429:309-18 (2001).

Schmitt-Grohe S, Eickmeier O, Schubert R et al. Ann Allergy Asthma Immunol. 89:599-605 (2002).

M5876 Mostesanib (See page 29 for more information) 5 mgC22H23N5O FW 373.45 [453562-69-1] 10 mgA small molecule antagonist of vascular endothelial growth factor receptors 1, 2 25 mgand 3 (“VEGFR1-3”), platelet-derived growth factor receptor (“PDGFR”) and stem

cell factor receptor (“c-kit”).

Kruser TJ, Wheeler DL, Armstrong EA, et al. Clin Cancer Res. 2010 May 27

M5675 Motilin, canine 0.5 mgC120H194N36O34 FW 2685.1 [85490-53-5] 1 mg

2.5 mg

M5776 Motilin, porcine 0.5 mgC120H188N34O35S FW 2699.1 [52906-92-0] 1 mgA peptide that plays a major role in the stimulation of smooth muscles in the 2.5 mg gastrointestinal tract.Kitazawa T, Taneike T, Ohga A. Peptides. 16:1243-1252 (1995).

M5794 Moxifloxacin Hydrochloride (See page 16 for more info) 100 mgC21H24FN3O4

.HCl FW 437.89 [186826-86-8] 500 mgAn 8-methoxy-fluoroquinolone antibacterial agent. 1 gNightingale CH. Pharmacotherapy. 20:245-56 (2000).

M8007 Mubritinb, free base 5 mgC25H23F3N4O2 FW 468.47 [366017-09-6] 25 mgA protein kinase inhibitor. It inhibits HER2, human epidermal growth factor receptor 100 mg2 tyrosine kinase.

Nagasawa J, Mizokami A, Koshida K, et al Int. J Urol 13:587-92 (2006).

Sugita S, Kawashima H, Tanaka T, et al Oncol Rep. 11:1273-1279 (2004).

HO

HN

NH

S

O

O

H-Phe-Val-Pro-Ile-Phe-Thr-

His-Ser-Glu-Leu-Gln-Lys-Ile-

Arg-Glu-Lys-Glu-Arg-Asn-

Lys-Gly-Gln-OH

Phe-Val-Pro-Ile-Phe-Thr-Tyr-

Gly-Glu-Leu-Gln-Arg-Met-

Gln-Glu-Lys-Glu-Arg-Asn-

Lys-Gly-Gln

O

O OH

N N

O

CO2HF

OHN

H

HH3C

.HCl

O O

OO

O

O

O

HO H

O

HH

HO

OH

H

H

Na

N

NH

N

O

NH

HN

O

N

O

N N

N

F

FF

NCl

CH3

H3C

HO

S COOH

Na


M9608 Myclobutanil 5 gC15H17ClN4 FW 288.78 [88671-89-0] 10 gA fungicide that inhibits ergosterol biosynthesis. 50 gQuinn JA et al. Pestic. Sci. 17:357 (1986).

M9710 Mycophenolic acid (See page 26 for more information) 50 mgC17H20O6 FW 320.34 [24280-93-1] 250 mgAn immunosuppressive drug used to prevent organ rejection.

Ginzler EM, Dooley MA, Aranow C, Kim MY, et al. New England Journal of Medicine. 353: 2219-2229 (2005).

M9643 Myelin Basic Protein (1-11), human 1 mgC52H88N22O17 FW 1293.42 [106128-98-7] 2 mg

5 mg

M9644 Myelin Basic Protein (87-99), guinea pig, human 1 mgC74H114N20O17 FW 1555.8 2 mg

5 mg

M9646 Myelin Basic Protein (68-82), guinea pig 1 mgC71H113N23O28 FW 1736.8 2 mg

5 mg

M9645 Myelin Oligodendrocyte Glycoprotein (35-55), rat 1 mgMOG (35-55) 2 mgC118H177N35O29S FW 2582.0 [163913-87-9] 5 mg

M9356 Myomodulin 1 mgC36H67N11O8S2 FW 846.13 [110570-93-9] 2 mgA neuropeptide that inhibits the electrophysiological effects of sensory neurons. 5 mgCritz SD, Baxter D. A. Byrne J.H. Journal of Neurophysiology 66: 1912-1926 (1991).

M9367 Myricetin 10 mgC15H10O8 FW 318.2 [529-44-2] 25 mgA common flavonol in plants, which inhibits the human P-form phenolsulfotransferase.

Eaton EA, Walle UK, Lewis AJ et al. Drug Metab Disp. 24:232-237 (1997).

M9634 Myriocin 1 mgC21H39NO6 FW 401.54 [35891-70-4] 5 mgAlso known as antibiotic ISP-1, thermozymodcidin is an atypical amino acid 10 mgderived from fungi. A very potent inhibitor of serine palmtoyl transferase. Possesses immunosuppressant activity and is 10X more potent than cyclosporine.Ciesek, S. Journal of Infectious Diseases (2008), 198(7), 1091-1093

M9368 Myristicin 100 mgC11H12O3 FW 192.21 d 1.1437 [607-91-0] 500 mgNatural product isolated from parsley oil. Inducer of glutathione S-transferase 1 g enzymes and inhibitor of chemical carcinogenesis.Zheng G-q, Kenney PM, Lam LKT. J. Agri. Food Chem. 40:107-110 (1992).

Zheng G-q, Kenney PM. Zhang J, Lam LKT. Carcinogenesis. 13:1921-23 (1992).

N0205 Nabumetone 5 gC15H16O2 FW 228.29 [42924-53-8] 25 gA non-steroidal anti-inflammatory drug. Works by inhibiting cyclooxygenase,

an enzyme responsible for making prostaglandins which are mediators of inflammation.

It also has chemopreventive effect on chemically induced mammary carcinogenesis in rats.

Matsunga K, Yoshimi N, Yamada Y et al. Jpn J Cancer Res. 89:496-501 (1998).

O

O

OCH3

CH2

O

OOH

HO

OH

OH

OH

OH

H-Tyr-Gly-Ser-Leu-Pro-Gln-

Lys-Ser-Gln-Arg-Ser-Gln-

Asp-Glu-Asn-OH

Ac-Ala-Ser-Gln-Lys-Arg-Pro-

Ser-Gln-Arg-His-Gly-OH

Met-Glu-Val-Gly-Trp-Tyr-Arg-

Ser-Pro-Phe-Ser-Arg-Val-Val-

His-Leu-Tyr-Arg-Asn-Gly-Lys

H-Tyr-Gly-Ser-Leu-Pro-Gln-

Lys-Ser-Gln-Arg-Ser-Gln-Asp-

Glu-Asn-OH

H-Pro-Met-Ser-Met-Leu-

Arg-Leu-NH2

CH3

O

H3CO

H3C

OH

ONH2

OHO

OH

HO

O

OHO

CH3

OMe

CH3

OH

O

H3C

Cl

CN

NN

N


N0114 Nadifloxacin (See page 16 for more information) 25 mgC19H21FN2O4 FW 360.38 [124858-35-1] 100 mgA fluoroquinolone antibacterial agent. It was found to inhibit the generation of 500 mg O2- and OH radicals by neutrophils.Ishikawa H, Tabusa F, Miyamoto H et al. Chem Pharm Bull 37:2103-2108 (1989).

Akamatsu H, Sasaki H, Kurokawa I et al. J Int. Med Res. 23:19-26 (1995).

N0123 Naftopidil 25 mgC24H28N2O3 FW 392.49 [57149-07-2] 100 mgAn anti-hypertension drug. 500 mgKanda, H. International Journal of Cancer (2007), Volume Date 2008, 122(2), 444-451.

N0262 Naphazoline Hydrochloride 25 gC14H14N2

.HCl FW 246.74 [550-99-2] 100 gNaphazoline produces inotropic effects via a-adrenoceptor stimulation.

Endoh M, Schumann HJ. Naunyn Schmiedebergs Arch Pharmacol. 287:377-89 (1975).

N0263 Naphazoline Nitrate 10 gC14H14N2

.HNO3 FW 273.29 [5144-52-5] 25 g100 g

N0161 β-Naphthoflavone 1 g5, 6 -Benzoflavone 5 gC19H12O2 FW 272.3 [6051-87-2]An inducer of cytochrome P450 enzyme system. Protects chemical-induced carcinogenesis

by enhancing the detoxification of carcinogens.

Callander RD, Mackay JM, Clay P. Mutagenesis. 10:517-22 (1995).

Anderson LM, Seetharam S. Cancer Res. 45:6384-9 (1985).

N0160 NAP 0.5 mgC36H60N10O12 FW 824.94 [211439-12-2] 1 mg

2.5 mg

N0163 2-(1,8-Naphthyridin-2-ly)phenol 500 mg2-NP 1 gC14H10N2O FW 222.24 [65182-56-1] 5 gIt was shown to enhance IFN-g ability to inhibit the proliferation of human breast.

cancer and fibrosarcoma cells.

Lynch RA, Etchin J, Battle TE, Frank DA Cancer Res. 67: 1254-1261 (2007).

N0061 D-Naproxen 5 gC14H14O3 FW 230.26 m.p. 155-1580C [22204-53-1] [a]66.80 25 gA non-steroidal anti-inflammatory agent found to significantly inhibit NNK 50 gactivation in lung tissues.

Bouchard L, Castonguay A. Drug Metab. Disp. 21: 293-298 (1993).

N0062 D,L-Naproxen 10 gC14H14O3 FW 230.26 m.p. 152-1540C [22204-53-1] 25 gA non-steroidal anti-inflammatory agent found to significantly 100 ginhibit NNK activation in lung tissues.

Bouchard L, Castonguay A. Drug Metab. Disp. 21: 293-298 (1993).

N

N

HCl

N

N

HNO3

O

O

N

CH3

F

N

HO

O

OH

O

H3CO

OH

O

CH3

H3CO

OH

O

CH3

N N

HO

H-Asn-Ala-Pro-Val-Ser-Ile-Pro-

Gln-OH

OH

O N

N

H3CO


N0068 Naringenin 5 gC15H12O5 FW 272.25 [480-41-1] 10 gThe aglycone of naringin, a dietary flavonoid found in grapefruit 25 gjuice. An effective anti-oxidant and antimutagen.

Guengerich FP, Kim DH. Carcinogenesis. 11:2275-2279 (1990).

Calomme M, Pieters L, Vlietinck A, Berghe D. Planta Med. 62:222-226 (1996).

N0069 Naringin 25 gC27H32O14 FW 580.53 [10236-47-2] 100 gA citrus bioflavonoid found to inhibit cytochrome P450 monooxygenase activity

in mouse liver. It prevents toxin-induced cytoskeletal disruption and apoptotic liver

cell death. In addition, it was found to have hypocholesterolemic effect by inhibiting

HMG-CoA reductase and ACAT activities.Ueng YF, Chang YL, Oda Y et al. Life Sci. 65:2591-2602 (1999).

Blankson H, Grotterod EM, Seglen PO. Cell Death Diff. 7:739-746 (2000).

Shin YW, Nok SH, Jeong TS et al. Int. J. Vit. Nutr. Res. 69:341-347 (1999).

N0075 Natamycin 25 mgPimaricin 50 mgC33H47NO13 FW 665.73 [7681-93-8] 100 mgA polyene antifungal compound, shown to potentiate bleomycin activity against murine tumors.

Komiyama K, Umezawa I, Kuwano M et al. Gann. 74:602-6 (1983).

Brothers AM, Wyatt RD. Avian Dis. 44:490-7 (2000).

N0212 Nedaplatin 10 mgC2H8N2O3Pt FW 303.18 [95734-82-0] 25 mgA platinum complex that has potent antineoplatic activity. 50 mgYamada H, Uchida N, Maekawa R, Yoshioka T. Cancer Lett. 172:17-25 (2001).

Uchida N, Takeda Y, Kasai H. Anticancer Res. 18:3375-9 (1998).

N1822 Nefazodone Hydrochloride 1 gC25H32ClN5O2

.HCl FW 506.48 [82752-99-6] 5 gAn antidepressant acts by modifying serotonin transmission. It also exhibits 25 ganalgesic effect in mice.

Eison AS, Eison MS, Torrente JR et al. Psychopharmacol Bull. 26:311-5 (1990).

Pick CG, Paul D, Eison MS. Pasternak GW. Eur J Pharmacol. 211:375-81 (1992).

Owens MJ, Ieni JR, Knight DL et al. Life Sci. 57:PL373-80 (1995).

N1721 Nefiracetam 100 mgC14H18N2O2 FW 246.3 [77191-36-7] 250 mgIs a nootropic drug of the racetam family used in the treatment of Alzheimer’s 1 g disease and other diseases related to learning and memory deficits.

Moriguchi, S. Molecular Pharmacology (2007), 71(2), 580-587.

Moriguchi, S. Journal of Neurochemistry (2008), 106(3), 1092-1103

N1744 Nelarabine 10 mgC11H15N5O5 FW 297.26 [121032-29-9] 25 mgA chemotherapy drug used in T-cell acute lymphoblastic leukemia. 100 mgBuie LW, Epstein SS, Lindley CM. Clin Ther. 29:1887-99 (2007).

Pt

O

O

H3N

H3N

O

O

O O

H

OH H

COOH

O

H3C

OH

OH

H

O

O

OH

OH NH2

CH3

CH3

H3C

HN

O

NO

O

OH

OOH

OO

OHO

OH

OH O

OHOH

CH3

HO

ON N

N

N

N Cl

HCl

O

N

NH2N N

N

OMe

O

HO

HO OH

OOH

HO O

OH


N1755 Neomycin sulfate 1 gC23H46N6O13

.3H2SO4 FW 908.9 [1405-10-3] 5 gAntibacterial produced by Streptomyces fradiae. 10 gTaborsky I, Nezval J, Smekal E, Janisch R. J Hyg Epidemiol Microbiol Immunol. 25 g 11:359-67 (1967). 100 gMacdonald RH, Beck M. Clin Exp Dermatol. 8:249-58 (1983).

N1656 Neopterin 10 mgC9H11N5O4 FW 253.21 [670-65-5]A prognostic marker for the progression of immunodefeciency.

Prommegger R, Winder B, Murr C et al. Ann Thorac Surg. 70:1861-4 (2000).

N1858 Neosolaniol 1 mgC19H26O8 FW 382.40 [36519-25-2] 5 mgA highly toxic trichothecene mycotoxin.

Janse van Rensburg DF, Thiel PG, Jaskiewicz K. Food Chem Toxicol. 1987 Oct;25(10):767-71.

N1757 Neostigmine Bromide 250 mgProstigmine 1 gC12H19BrN2O2 FW 303.20 [114-80-7]An acetylcholine esterase inhibitor. It has protective effects against gastric carcinogenesis.

It also may provide analgesia in patients with pain arising from neoplasia.

Tatsuta M, Iishi H, Baba M, Taniguchi H. Int J Cancer. 51:767-71 (1992).

Klamt JG, Dos Reis MP, Barbier neto J, Prado WA. Pain. 66:389-91 (1996).

N1769 Nerolidol 5 gC15H26O FW 222.37 [7212-44-4] 25 gIt has inhibitory effects on carcinogenesis of the large bowel.Warttenberg LW. Carcinogenesis. 12:151-2 (1991).

N1873 Nesiritide Acetate (BNP-32) Please inquireC143H244N50O42S4 FW 3464.1 [11447-18-0]Nesiritide is a sterile, purified preparation of a new drug class, human B-type natriuretic

peptide (hBNP), and is manufactured from E. coli using recombinant DNA technology.

Sun Z, Chen J, Yao H, Liu L, Wang J, Zhang J, Liu JN. Protein Expr Purif. 43:26-32 (2005).

N1976 Netilmicin Sulfate 5 mg1-N-Ethylsisomicin 10 mg(C21H41N5O7)2

.5H2SO4 FW 1441.56 [56391-57-2] 25 mgA aminoglycoside antibiotic. It is a semisynthetic derivative of gentamycin.

Scuderi AC, Paladino GM, Marino C et al. Cornea. 22:468-72 (2003).

Adelman RD, Conzelman G, Spangler W et al. Curr Probl Clin Biochem. 9:166-82 (1979).

N1977 Neurokinin A (4-10) 1 mgC34H54N8O10S FW 766.92 [97559-35-8] 2 mgA selective NK1 receptor agonist against tachykinin receptors. 5 mgTeixeira RM, Santos AR, Ribeiro SJ, Calixto JB, Rae GA, DeLima TC. Eur J Pharmacology 311: 7-14 (1996).

N1978 Neurokinin B 1 mgC55H79N13O14S2 FW 1210.45 [86933-75-7] 2 mgA peptide thought to be responsible for pre-eclampsia in women. 5 mgPage NM, Woods RJ, Gardiner SM, Lomthaisong K, Gladwell RT, Butlin DJ, Manyonda IT, Lowry PJ. Nature 405: 797-800 (2000).

N(CH3)3

OOCN(CH3)2

Br

OH

O

O

NH2

H2N

O

H2N

HO

HO

O

HN CH3

NH

H3C OH

CH3

2

5H2SO4

HN

N N

N

H2N

OH

OH

OH

O

H-Ser-Pro-Lys-Met-Val-Gln-Gly-

Ser-Gly-Cys-Phe-Gly-Arg-Lys-

Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-

Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-

Arg-His-OH (Cys10-Cys26)

H-Asp-Ser-Phe-Val-Gly-Leu-Met-

NH2

H-Asp-Ser-Phe-Val-Gly-Leu-Met-

NH2

O

O

O

O

O

O

CH2NH2

HO

HO

H2N

NH2

NH2

HO

H

OH

HHHOH2C

H

H2N

R2 R1

HO

HO H2SO4

Neomycin BR1=H, R2=CH2NH2

Neomycin CR1=CH2NH2, R2=H

O

HO

O

O

O

O

OH

HH

O


N1979 Neuromedin 1 mgC38H63N7O8 FW 745.97 [102577-25-3] 2 mg

5 mg

N1980 Neuromedin B, porcine 1 mgC52H73N15O12S FW 1132.3 [87096-84-2] 2 mgNeuromedin B and C are bombesin-like peptides. They have various 5 mg physiological effects, including regulation of exocrine and endocrine secretions, smooth muscle contraction, feeding, blood pressure, blood glucose, body temperature and cell growth.Ohki-Hamazaki H. Prog Neurobiol. 62:297-312 (2000).

N1981 Neuromedin C, porcine GRP (18-27) 1 mgC50H73N17O11S FW 1120.3 [81608-30-2]

N1982 Neuromedin U, rat 1 mgC124H180N34O31 FW 2643.03 [117505-80-3] 2 mgA neuropeptide which affects smooth muscle. It was first isolated from porcine spinal cord 5 mgHoward AD Et Al. Nature 406: 70-4 (2000).

N1984 Neuropeptide FF F-8-F-NH2 5 mgC54H76N14O10 FW 1081.3 [99566-27-5] 10 mg

25 mg

N1985 Neuropeptide K, porcine 5 mgC175H284N52O52S FW 5980.6 10 mgIsolated from porcine spinal cord. It was shown to exert control over neural 25 mgtransmission.Tatemoto K, Lundberg JM, Jornvall H, Mutt V. Biochem Biophys Res Commun 128: 947-53 (1985).

N1983 Neuropeptide Y (3-36), human 0.5 mgC175H269N53O54S FW 4011.48 1 mgA neuropeptide thought to be associated with food intake. 2.5 mgBatterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE,

Low MJ, Ghatei MA, Cone RD, Bloom SR. Nature 418: 650-4 (2002).

N1987 Neuropeptide Y (13-36), human 0.5 mgC134H207N41O36S FW 3000.46 1 mg

2.5 mg

N1986 Neuropeptide Y, human, rat 5 mgC189H285N55O57S FW 4271.7 10 mg

25 mg

N1988 γ-Neuropeptide, rabbit 0.5 mgC99H158N34O29S FW 2320.64 [114882-65-4] 1 mgWhen injected into the heart of a rabbit, a decrease in blood flow was induced. 2.5 mgAllen JM, Bircham PM, Edwards AV, Tatemoto K, Bloom SR. Regul Peptide 6: 247-53 (1983).

N1989 Neurotensin 1 mgC78H122N21O20 FW 1672.9 [39379-15-2] 2 mgA gut regulatory peptide that exerts a wide range of biological actions on 5 mg gastrointestinal tissues. It has been shown to potentiate the proliferative effects of

insulin on IMR90 human fibroblasts.Scarpa RC, Carraway RE, Cochrane DE. Peptides. 25:1159-69 (2004).

Assimakopoulos SF, Vagianos CE, Zervoudakis G et al. Regul Pept. 120:185-93 (2004).

H-Tyr-Lys-Val-Asn-Glu-Tyr-Gln-

Gly-Pro-Val-Ala-Pro-Ser-Gly-

Gly-Phe-Phe-Leu-Phe-Arg-Pro-

Arg-Asn-NH2

Phe-Leu-Phe-Gln-Pro-Gln-Arg-

Phe-NH2

H-Asp-Ala-Gly-His-Gly-Gln-

Ile-Ser-His-Lys-Arg-His-Lys-

Thr-Asp-Ser-Phe-Val-Gly-

Leu-Met-NH2

pGlu-Leu-Tyr-Glu-Asn-Lys-

Pro-Arg-Arg-Pro-Tyr-Ile-Leu

H-Lys-Ile-Pro-Tyr-Ile-Leu-OH

Gly-Asn-Leu-Trp-Ala-Thr-Gly-

His-Phe-Met-NH2

Gly-Asn-Leu-Trp-Ala-Thr-Gly-

His-Phe-Met-NH2

Asp-Ala-Asp-Ser-Ser-Ile-Glu-

Lys-Gln-Val-Ala-Leu-Leu-Lys-

Ala-Leu-Tyr-Gly-His-Gly-Gln-

Ile-Ser-His-Lys-Arg-His-Lys-

Thr-Asp-Ser-Phe-Val-Gly-Leu-

Met-NH2

H-Pro-Ala-Glu-Asp-Met-Ala-Arg-

Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-

Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-

Tyr-NH2

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-

Pro-Gly-Glu-Asp-Ala-Pro-Ala-

Glu-Asp-Met-Ala-Arg-Tyr-Tyr-

Ser-Ala-Leu-Arg-His-Tyr-Ile-

Asn-Leu-Ile-Thr-Arg-Gln-Arg-

Tyr-NH2

H-Pro-Ala-Glu-Asp-Met-Ala-Arg-

Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-

Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-

Tyr-NH2


N1990 [Gln4] Neurotensin 1 mgC78H122N22O19 FW 1671.9 [61445-54-3] 2 mg

5 mg

N1991 [D-Trp11] Neurotensin 5 mgC80H122N22O19 FW 1696.0 [75644-95-0] 10 mg

25 mg

N1992 Neurotensin (1-11) 1 mgC66H99N19O18 FW 1446.66 [74032-89-6] 2 mg

5 mg

N1993 Neurotensin (9-13) 5 mgC32H52N8O7 FW 660.82 10 mg

25 mg

N1994 Neurotensin, frog 0.5 mgC70H115N23O17 FW 1550.84 1 mg

2.5 mg

N1995 Neurotensin, guinea pig 1 mgC76H119N21O21 FW 1662.92 2 mg

5 mg

N3301 Niacin 10 gC6H5NO2 FW 123.11 [59-67-6] 50 gA water-soluble vitamin of the B complex occurring in various animal and plant tissues.

Jacob RA, Swendseid ME, McKee RW, et al. J. Nutr. 119:591-598 (1989).

N3208 Nicardipine 1 gC26H29N3O6 FW 479.52 [55985-32-5] 5 gNicardipine is a calcium channel blocker. 25 gJapelj, I., et al. Eur. J. Pharmacol. 369: 43-47 (1999).

Thellung, S., et al. Neurobiol. Dis. 7: 299-309 (2000).

N3310 Nicotinamide 50 gC6H6N2O FW 122.12 [98-92-0]A naturally occurring vitamin that is a protease inhibitor. Topical nicotinamide has demonstrated

preventive activity against photo carcinogenesis in mice by elevating skin nicotinamide-adenine

dinucleotide (NAD) content. It also has protective effects against lung and pancreatic

carcinogenesis.

Gensler HL, Williams T, Huang AC, Jacobson EL. Nutr Cancer. 34:36-41 (1999).

Nikonova TV, Draudin-Krylenko VA, Bukin Iu V, Turusov VS. Eksp Onkol. 10:17-9 (1998).

Pour PM, Lawson T. J Natl Cancer Inst. 73:767-70 (1984).

N3213 Nidulal 0.5 mgC15H16O5 FW 276.28A natural product isolated from Nidula candida. It induces differentaition of human HL-60

promyelocytic leukemia cells, and preferentially activates the transcription factor complexAP-1-mediated expression of secreted alkaline phosphatase in COS-7 cells.

Erkel G, Necker U, Anke T et al. J Antibiot (Tokyo) 49:1189-95 (1996).

N

NH2

O

pGlu-Leu-Tyr-Gln-Asn-Lys-Pro-

Arg-Arg-Pro-Tyr-Ile-Leu-OH

pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-

Arg-Arg-Pro-D-Trp-Ile-Leu-OH

pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-

Arg-Arg-Pro-Tyr-OH

H-Arg-Pro-Tyr-Ile-Leu-OH

H-pGlu-Ser-His-Ile-Ser-Lys-

Ala-Arg-Arg-Pro-Tyr-Ile-Leu-

NH2

H-pGlu-Leu-Tyr-Glu-Asn-Lys-

Ser-Arg-Arg-Pro-Tyr-Ile-Leu-

OH

O OO

OO

N

OH

O

HN

CO2Me

O

ON

O2N


N3228 Nifedipine 1 g4-(2'nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine 5 gC17H18N2O6 FW 346.3 [21829-25-4] 25 gCa+2 channel blocker, induces apoptosis in human glioblastoma cells.Miller RJ. Science. 235:46 (1987).

N3422 Nifekalant Hydrochloride 10 mgC19H27N5O5

.HCl FW 441.91 [130656-51-8] 25 mgA class III antiarrhythmic drug. It has been shown to be effective against ventricular tachyarrhythmias by inhibiting HERG channels in a voltage-dependent and frequency-dependent manner.Kushida S, Ogura T, Komuro I et al. Eur J Pharmacol. 457:19-27 (2002).

Shiga T, Matsuda N, Fuda Y et al. J Cardiol. 39:159-64 (2002).

N3322 Niflumic acid (See page 17 for more information) 10 gC13H9F3N2O2 FW 282.22 [4394-00-7] 25 gA NSAID, found to be a potent anion channel blocker.

White MM, Aylwin M. Mol. Pharm. 37:720-724 (1990).

N3323 Nifuratel 10 gC10H11N3O5S FW 285.28 [4936-47-4] 25 gNifuratel appears to have a broad antibacterial spectrum of action and is effective 100 gagainst Chlamydia trachomatis and Mycoplasma spp. as well as fungal infections

from Candida spp.Grüneberg RN, Leakey A. Br. Med. J. 2:908-910 (1976).

N3520 Nifursol 25 gSalfuride 100 gC12H7N5O9 FW 365.21 [16915-70-1]An antibiotic used as a feed additive.Callait MP, Granier C, Chauve C et al. Poult Sci. 81:1122-7 (2002).

Kowalski P, Oledzka I, Lamparczyk H. J Pharm Biomed Anal. 32:937-47 (2003).

N3225 Nigericin 1 mgC40H67O11Na FW 747.0 [28643-80-3] 5 mgA potassium ionophore, found to induce cell death and promote the maturation 10 mg and release of IL-1beta in lipopolysaccharide primed monocytes and macrophages.

It also enhances rapamycin action.Fang A, Wong GK, Demain AL. J Antibiot (Tokyo). 53:158-62 (2000).

Hentze H, Lin XY, Choi MS et al. Cell Death Differ. 10:956-68 (2003).

N3346 Nilotinib (See page 24 for more information) 10 mgC28H22F3N7O FW 529.52 [641571-10-0] 25 mgTyrosine kinase inhibitor used in the treatment of drug resistant myelogenous 100 mg leukemia with promising results often resulting in full recovery of white blood cell count. Day, E. European Journal of Pharmacology (2008), 599(1-3), 44-53.

Tiribelli, M. Leukemia Research (2009), 33(1), 174-177.

N3450 Nimesulide (See page 17 for more information) 5 gC13H12N2O5S FW 308.31 [51803-78-2] 10 gInhibits prostaglandin synthetase (COX-2 inhibitor), and has anti-inflammatory 25 gactivity. It induces apoptosis and inhibits carcinogenesis.

Huskisson EC. Clin Exp Rheumatol. 19:S21-5 (2001).

Kitayama W, Denda A, Okajima E. Carcinogenesis. 20:2305-10 (1999).

Hida T, Kozaki K, Muramatsu H. Clin Cancer Res. 6:2006-11 (2000).

Nakatsugi S, Ohta T, Kawamori T. Jpn J Cancer Res. 91:886-92 (2000).

O

NHSO2CH3

NO2

O O-

O O

O O O

OMe

HHH

H

H

OH

HOOH

Na+

N

NHN

N

OH

NO2

O

H3C

O

CH3

.HCl

NH

OO

O O

NO2

H3C CH3

N

COOH

HN CH3

NHN

O

N

CH3

NH

N N

N

H3C

FFF

HO

O2N NO2

HN

NO

OO2N

S

O

N N

O NO2O


N3448 Nimodipine 500 mgC21H26N2O7 FW 418.44 [66085-59-4] 1 gA calcium channel antagonist. 5 gGupta MC, Garg SK, Das BP, Bhargava VK. Indian J Physiol Pharmacol. 47:347-51 (2003).

N3452 Nimustine Hydrochloride 100 mg1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitrosourea,ACNU 500 mgC9H13ClN6O2

.HCl FW 309.16 [55661-38-6] 1 gDNA cross-linker used to treat malignant glioma.

Kono K, Takahashi JA, Ueba T. J. Neuro-Oncol. 56:101-108 (2002).

9-Nitro-20(S)-Camptothecin (See Camptothecin, 9-nitro-20(S))

N3278 7-Nitroindazole 500 mgC7H5N3O2 FW 163.14 [2942-42-9] 1 gA neuronal nitric oxide synthase (nNOS) inhibitor. It enhances amphetamine- 5 gevoked release, and kainic acid induced cholinergic neurotoxicity in the rat striatum.

Guevara BH, Cespedes GC, Cubeddu LX. Cell Mol Neurobiol. 22:827-34 (2002).

Nowak P, Brus R, Oswiecimska J et al. J Physiol Pharmacol. 53:251-63 (2002).

N3276 Nitroso(acetoxymethyl)methylamine 10 mgC4H8N2O3 FW 132.12 [56856-83-8] 50 mgStable derivative of dimethylnitrosoamine metabolite, a potent carcinogen. 100 mgFrank N, Janzowski C, Wiessler M. Biochem. Pharm. 29:383-7 (1980).

Rice JSR, Wenk JM, Roller ML, Keefer LK. J. Nalt. Cancer Inst. 58:1531-35 (1977).

N3378 S-Nitrosoglutathione 5 mgC10H16N4O7S FW 336.32 [57564-91-7] 10 mgAn antioxidant that annihilates free radicals and promotes neuro protection 25 mg via its c-GMP independent nitrosylation actions. It is also reported that

S-nitrosoglutathione induces apoptosis in human adenocarcinoma cells in the presence of Cu and Ni ions.

Chiueh CC, Rauhala P. Free Radic Res. 31:641-50 (1999)

Ho Y S, Liu H L, Duh J S et al. Molecular Carcinogenesis. 26:201-11 (1999).

N3584 Nivalenol 1 mgC15H20O7 FW 312.32 [23282-20-4] 5 mgNivalenol is a type - B trichothecene mycotoxin, produced by molds such as

Fusarium cerealis, Fusarium graminearum. It is an apoptosis inducer, inhibits protein

synthesis and nucleic acid synthesis in vitro.Cao PH, Cao JL, Cao LM, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26:313-315 (2010).Dewa Y, Kemmochi S, Kawai M, et al. Exp. Toxicol. Pathol. 63: 17-24 (2011).

N3496 Nizatidine 5 gC12H21N5O2S2 FW 331.46 [76963-41-2] 10 gA H2-receptor antagonist, found to be a potent inhibitor of gastric acid secretion.

Lin TM, Evans DC, Warrick MW et al. J Pharmacol Exp Ther. 239:406-10 (1986).

Abdel-Rahman SM, Johnson FK, Connor JD et al. J Pediatr Gastroenterol Nutr. 38:442-51 (2004).

N5605 Nobiletin 25 mgC21H22O8 FW 402.39 [478-01-3] 100 mgA flavonoid isolated from citrus peels like in tangerine.

Whitman SC, Kurowska EM, Manthey JA, et al. Atherosclerosis 178:25-32 (2005).

HOOCHN

NH

COOH

O

O

NH2H

S

N

O

N

S

N

CH3

H3C

S

NH

HN

NO2

CH3

H3C O

O

N

NO

CH3

N

N

NO2H

N

NH3C

NH2

HN N

Cl

O

N

OHCl

HN CH3H3C

NO2

OOCH3

OH3C

OOCH3

O

O O

H

HO

OH

H

HO

HO

OO

O

O

O O

O

O


N5210 Nociceptin 1 mgOrphanin FQ

C79H129N27O22 FW 1809.1 [170713-75-4]The endogenous ligand for the opioid-receptor-like receptor 1. It mediates essential functions in

the central and peripheral nervous systems.

Li N, Wei SY, Yu LC et al. Brain Res. 1025:67-74 (2004).

N5211 Nocistatin 0.5 mgC32H56N10O12 FW 772.86 1 mg

2.5 mg

N5409 Nocodazole 10 mgC14H11N3O3S FW 301.32 [31430-18-9] 50 mgMicrotubule inhibitor. Karbowski M, Spodnik JH, Teranishi Ma et al. J Cell Sci. 114:281-291 (2001).

Samson F, Donoso JA, Heller-Bettinger I et al. J Pharmacol Exp Ther. 208:411-7 (1979).

N5550 Nomilin 25 mgC28H34O9 FW 514.56 m.p. 257-2610C [1063-77-0] 100 mgNomilin is a natural product isolated from grapefruit seed. It is an inducer of 500 mgPhase II detoxifying enzymes and inhibitor of chemcially induced carcinogenesis.

Maier V P, Hasegawa S, Bennett, R. D, Echols L.C. In: Citrus Nutrition and

Quality, ed. by S. Nagy and J. A. Attaway, ACS Symposium Series 143, ACS, Washington, D.C. pp 63-81 (1980).

Lam LKT, Hasegawa S. Nutr. Cancer. 12:43-47 (1989).

Miller EG, Fanous R, Rivera-Hidalgo F et al. Carcinogenesis. 10:1535-1537 (1989).

N5652 Nonactin 1 mgC40H64O12 FW 736.93 [6833-84-7] 5 mgA selective ionophore used in the determination of ammonium ions. 10 mgKarakus E, Pekyardimci S, Kilic E. Artif Cells Blood Substit Immobil Biotechnol. 34:523-34 (2006).

N5655 Nonoxynol, n=9 50 gC33H60O10 FW 616.82 [26027-38-3] 100 gPolyoxynol nonylpheyl ether, a surfactant used as a vaginal contraceptive and condom luricant.

Van damme L. AIDS Read. 10:552-4. (2000).

Sonnenschein C, Soto AM. J Steroid Biochem Mol Biol. 65:143-50 (1998).

Noradrenaline (See Norepinephrine)

N5669 Nordihydroguaiaretic acid 500 mgC18H22O4 FW 302.36 [500-38-9] 1 gA naturally ocurring antioxidant and potent lipoxygenase inhibitor 5 gwith antipromoter activity.

Nakadate T, Yamamoto S, Iseki H et al. Gann. 73:841-843 (1982).

N5766 Norepinephrine bitartrate 500 mgC8H11NO3

.C4H6O6.H2O FW 337.28 [69815-49-2] 1 g

Norepinephrine activates protein kinases Erk1/2. It is cytotoxic to human promyelocytic

leukemic HL-60 cells.Lindquist JM, Fredriksson JM, Rehnmark S et al. J Biol Chem. 275:22670-7 (2000).

Kawase M, Motohashi N, Kurihara T et al. Anticancer Res. 18:1069-74 (1998).

OH

OH

HO

HO H3C CH3

C9H19 (OCH2CH2)9OH

O

O

O

CH3

O

O

CH3

H H

H3C

O

H3C

CH3

O

O

CH3

H HO

O

O

CH3

O

CH3

HH

H H

H-Glu-Gln-Lys-Gln-Leu-Gln-OH

Phe-Gly-Gly-Phe-Thr-Gly-Ala-

Arg-Lys-Ser-Ala-Arg-Lys-Leu-

Ala-Asn-Gln

NH

O

O

S NH

N O

OH

OH

HONH2

O

HO

OH

O

OH

HO

H2O

O

O

OOH

H

O

O

H

O

O

O


N5767 Norethindrone 250 mg Norethisterone 1 gC20H26O2 FW 298.42 [68-22-4] 5 gA synthetic progestin that possesses antiestrogenic effects. It is progestational in low dose and antiestrogenic in high dose. It has also been shown to cause a time-dependent loss of cytochrome P-450 when incubated in vitro with rat liver microsomal fractions and NADPH-generating systems.White IN, Muller-Eberhard U. Biochem J. 166:57-64 (1997).

Tamaya T, Ishihara S, Motoyama T et al. Nippon Naibunpi Gakkai Zasshi. 51:1033-42 (1975).

Norethisterone (See Norethindrone)

N5768 Norfloxacin (See page 16 for more information) 10 gC16H18FN3O3 FW 319.33 m.p. 227-2280C [70458-96-7] 50 gA fluorosquinolone antibacterial.

N5769 Norfloxacin Nicotinate 10 gC16H18FN3O3C6H5NO2 FW 442.44 [118803-81-9] 50 g

Norgestrel (See Levonorgestrel)

N5778 Notoginsenoside R1 5 mgC47H80O17 FW 919.10 [80418-24-2] 10 mgActive ingredient isolated from Panax notoginseng. It induces tissue-type 25 mg plasminogen activator synthesis in cultured human umbilical vein endothelial cells

Zhang W, Wojta J, Binder BR. Arterio Throm. 14:1040-1046 (1994).

N6020 NPF 1 mgC51H80N15O19P FW 768.79 2 mg

5 mg

N6076 N(p-Tosyl)-GPR-pNA 100 mgC26H34N8O7S FW 602.0

N7604 NTB (Naltriben) 0.5 mgC50H65N11O11S2 FW 1060.29 1 mgAn opoid antagonist that has been shown to suppress alcohol intake in rats. 2.5 mgKrishnan-Sarin S, Portoghese PS, Li TK, Frohlich JC. Pharmcol Biochem Behav 52: 153-9 (1995).

N9874 Nystatin 500 KUC47H75NO17 FW 926.09 [1400-61-9] 1 MUAn antifungal drug. 5 MUPatton LL, Bonito AJ, Shugars DA. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 92:170-9 (2001).

O0829 Ochratoxin A 1 mgC20H18ClNO6 FW 403.81 m.p. 1690C [303-47-9] 5 mgA toxic fungal metabolite and carcinogen. Inhibits phosphorylase

and mitochondrial respiration in rat liver.

Applegate KL, Chipley JR. Adv. Appl. Microbiol.16:97-109 (1973).

Meisner H, Chan S. Biochemistry. 13:2795-2800 (1974).

O

CH3

H3C

HO

H3C

O HO OH OH OH O

COOH

OH

OH

O

OCH3

OH

NH2OH

OH

N

COOH

O

F

N

CH3

HN

N

COOH

N

O

CO2H

CH2CH3

F

N

HN

N(p-Tosyl)-Gly-Pro-Arg-pNA

H-Lys-Arg-Ser-Tyr(PO3H2)-Glu-

Glu-His-Ile-Pro-OH

H-D-Phe-Cys-Tyr-D-Trp-Orn-

Thr-Pen-Thr-NH2(Cys2-Pen7)

O

Cl

OOHO

N

CO2H

H

CH3

O

H H

CH3

OH

H H

CH

HOH

CH3CH3 H

H

O CH3

CH3

CH3

HOH3C

H

CH3

CH3O

O

HO

HOHO

OH

OO

OH

OH

CH2OH

O

HOHO


O0978 Octaneuropeptide 1 mgC41H74N12O11 FW 911.1

O0977 Octopamine HCl 1 gC8H11NO2

.HCl FW 189.64 [770-05-8] 5 gOctopamine is a neuromodulator that occurs naturally in nervous tissues in 25 gmany species of animals.

Goaillard JM, Schulz DJ, Kilman VL et al. J Neurosci. 24:7063-73 (2004).

Roeder T, Seifert M, Kahler C et al. Arch Insect Biochem Physiol. 54:1-13 (2003).

O1078 Octreotide Acetate 1 mgSandostatin 5 x 1 mgC49H66N10O10S2

.2C2H4O2 FW 1139.36 [79517-01-4]Somatostatin analogue with antiproliferative effect. It is able to inhibit angiogenesis induced by hepatocellular carcinoma in vivo, and Akt/PKB and telomerase activity of SGC7901 cells.

Stockmann F, Creutzfeldt WZ. Gastroenterol. 26:665-75 (1988).

Jia WD, Ku GL, Sun HC et al. Hepatobiliary Pancreat Dis Int. 2:404-9 (2003).

Gao S, Yu BP, Li Y et al. World J Gastroenterol. 9:2362-5 (2003).

O1176 n-Octyl Caffeate (See page 10 for more info) 5 mg Caffeic acid n-octyl ester, 3,4-dihydroxycinnamic acid n-octyl ester. 25 mgC17H24O4 FW 292.37Antioxidant and supressor of iNOS. Induces apoptosis in human leukemia U937 cells.

Etzenhouser B et al. Bioorg. Med. Chem. 9:199 (2001).

Hsiao G et al. Biochem. Pharmacol. 65:1383 (2003).

Ujibe M et al. Biol. Pharm. Bull. 28:2338 (2005).

O1177 n-Octyl-3,4-Dimethylcaffeate (See page 10 for more info) 5 mg3,4-Dimethylcaffeic acid n-octyl ester; 3,4-dimethoxycinnamic acid n-octyl ester 25 mgC19H28O4 FW 320.42Derivative of n-octyl-caffeate.

O1178 n-Octyl-3-methylcaffeate (See page 10 for more info) 5 mg3-Methylcaffeic acid n-octyl ester;4-Hydroxy-3-methoxycinnamic acid n-octyl ester 25 mgC18H26O4 FW 306.40Derivative of n-octyl-caffeate.

O1179 n-Octyl-4-methylcaffeate (See page 10 for more info) 5 mg4-Methylcaffeic acid n-octyl ester; 3-Hydroxy-4-methoxycinnamic acid n-octyl ester 25 mgC18H26O4 FW 306.40Derivative of n-octyl-caffeate.

O2144 Ofloxacin 5 gC18H20FN3O4 FW 361.37 m.p. 250-2570C [82419-36-1] 10 gA broad spectrum, fluorinated antibacterial quinolone. 50 gSiebert G et al. Eur. J. Clin. Microbiol. 2:548 (1983).

O2146 R-(+)-Ofloxacin Hemihydrate 1 mgC18H20FN3O4 FW 361.37 [100986-86-5] 5 mgThe optically active form of ofloxacin. 10 mg

N

N

H3C

N

O

F

O

COOH

COOH

H

N

O

CO2HF

N

N

H3C

O

CH3

H3C OH

OH

NH-Cys-Thr-Lys-Trp-D-Phe-Cys-Phe-D

HO

NH2

OH

.HCl

OH

OH

O

OH3C(H2C)7

OCH3

OCH3

O

OH3C(H2C)7

OCH3

OH

O

OH3C(H2C)7

OH

OCH3

O

OH3C(H2C)7

Arg-Pro-Gly-Leu-Leu-Asp-Leu-

Lys


O2145 Ofloxacin Hydrochloride (See page 16 for more info) 5 gC18H20FN3O4

.HCl FW 397.94 [82419-36-1] 10 g50 g

O4101 Okadaic Acid (See page 22 for more information) 25 µgC44H68O13 FW 805.00 [78111-17-8] 50 µgNon-phorbol type tumor promoter. It is also a potent inhibitor 100 µgof protein phosphatases in numerous cell types. 1 mgSuganuma M et al. Proc. Natl. Acad. Sci. USA 85:1768-1771 (1988).

Cohen P et al. Trends Biochem. Sci. 15: 98-102 (1990).

O4102 Okadaic Acid Ammonium Salt (See page 22 for info) 25 µgC44H67O13

.NH4 FW 822.04 [155716-06-6] 100 µgAmmonium salt form of okadaic acid, with somewhat greater stability after it 1 mgis put into organic solvents.

O4200 Okadaic acid C8 diol ester (See page 22 for more info) 50 µgC52H80O14 FW 929.30The C8 diol ester of okadaic acid is itself a fragment of a precursor to okadaic acid

produced by Prorocentrum lima. Sold by LKT under license from the manufacurer, MARBIONC.

Hu, T. et al. J. Nat. Prod. (1992) 55, 1631.

O4202 Okadaic acid methyl ester (See page 22 for more info) 100 µgC45H70O13 FW 819.10Esters of okadaic acid are inactive in vitro against protein phosphatasesSold by LKT under license from the manufacurer, MARBIONC.Nishiwaki, S. et al. Carcinogenesis (1990) 11, 1837–1841.

O4104 Okadaic Acid Sodium Salt (See page 22 for more info) 25 µgC44H67O13

.Na FW 827.0 [209266-80-8] 100 µgSodium salt form of okadaic acid, with somewhat greater stability after 1 mgit is put into organic solvents.

O4204 Okadaol 100 µgC44H70O12 FW 791.10Okadaol is derived from okadaic acid by reduction of the carboxyl group and is inactive against protein phosphatases. Sold by LKT under license from the manufacurer, MARBIONC.Nishiwaki, S. et al. Carcinogenesis (1990) 11, 1837–1841.

O4402 Olaparib (See page 30 for more information) 5 mgC24H23FN4O3 FW 434.47 [763113-22-0] 10 mgA potent orally active inhibitor of PARP [Poly(adenosine diphosphate-ribose) 25 mgpolymerase]-1 and PARP-2.

KA Menear et al. J. Med. Chem. 51:6581–6591 (2008).

S Vasiliou et al. Olaparib. Drugs of the Future. 34(2), 101 (2009).

O4417 Oleanolic Acid 100 mgC30H48O3 FW 456.71 [508-02-1] 500 mgIs a naturally occurring triterpenoid found in Phytolacca Americana and garlic. 1 g Exhibits strong anti-HIV activity. Mechanism of action is the induction of iNOS and of Cyclooxygenase 2.Sultana, N. Journal of Enzyme Inhibition and Medicinal Chemistry (2008), 23(6), 739-756.

Rodriguez-Rodriguez, R. British Journal of Pharmacology (2008), 155(4), 535-546. H3C CH3

CH3H3C

HO

CH3 CH3 H

OH

O

H

H CH3

COONa

O

O

O

O

O

O

O

H3C

OH

H

OH

H

HHO

CH3

HOH

H3C

H

CH3

CH2

H3C

COONH4

O

O

O

O

O

O

O

H3C

OH

H

OH

H

HHO

CH3

HOH

H3C

H

CH3

CH2

H3C

COOH

O

O

O

O

O

O

O

H3C

OH

H

OH

H

HHO

CH3

HOH

H3C

H

CH3

CH2

H3C

N

COOH

O

F

N

NH3C

OCH3

O

O

OH

O

O

OO

O

OH

O

O

OHHH

H

H

H

H

H

OH

HO

O

O

OH

O

O

OO

O

OH

O

O

OHHH

H

H

H

H

H

OH

O

O

OH

O

O

OO

O

OH

HO

OHHH

H

H

H

H

H

OH

HN

N

O

O

N

N

O

F


O4533 Oligomycins 1 mg [1404-19-9] 5 mgA mixture of mostly oligomycins A, B and C. Has antibiotic properties. 10 mgInhibits membrane bound mitochondrial ATPase and phosphoryl group transfer.

Nagamune H et al. Biochim. Biophys. Acta 1141:231-237 (1993).

O4531 Oligomycin A 1 mgC45H74O11 FW 791.06 [579-13-5] 5 mgA macrolide antibiotic isolated from Streptomyces diastatochromogenes that inhibits

membrane bound mitochondrial ATPase.Tettamanti G, Malagoli D, Marchesini E, et. al. Cell Tissue Res. 326:179-86 (2006).Roberton AM, Holloway CT, Knight IG, Beechey RB. Biochem J. 108:445-56 (1968).

O4532 Oligomycin B 1 mgC45H72O12 FW 805.05 [11050-94-5] 5 mgA macrolide antibiotic isolated from Streptomyces diastatochromogenes that inhibits

membrane bound mitochondrial ATPase.

Prouty WF, Thompson RM, Schnoes HK, et al. Biochem Biophys Res Commun. 44:619-27 (1971).

von Glehn M, Norrestam R, Kierkegaard P, et al. FEBS Lett. 20:267-269 (1972).

O4556 Olomoucine 5 mgC15H18N6O FW 298.34 [101622-51-0] 25 mgPotent selective and competitive inhibitor of cyclin-dependent kinases. 100 mgVesely J et al. Eur J Biochem. 224:771-86 (1994).

O4672 Olsalazine Sodium 25 mgC14H8N2Na2O6 FW 346.2 [6054-98-4] 100 mgA medicine used in the treatment of ulcerative colitis converted to 5-amino- 250 mgsalicylic acid in the colon.

Hao, Junming. Shijie Huaren Xiaohua Zazhi (2005), 13(19), 2392-2394.

O4578 Oltipraz 250 mgC8H6N2S3 FW 226.34 [64224-21-1] 500 mgAn antischistosomiasis drug found to inhibit carcinogenesis. It is effective 1 g against several chemically induced tumor models. Its mechanism of action is

believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding.

Bueding E, Dolan P, Leroy JP. Res Commun Chem Pathol Pharmacol. 37:293-303 (1982).

Wattenberg LW, Bueding E. Carcinogenesis. 7:1379-81 (1986).

Kensler T, Styczynski P, Groopman J et al. J Cell Biochem Suppl. 16I:167-72 (1992).

O4917 Omeprazole (See page 27 for more information) 1 gC17H19N3O3S FW 345.42 [73590-58-6] 5 gA proton pump inhibitor. 10 gFaiss S, Scherubl H, Riecken EO, Wiedenmann B. Recent Results Cancer Res. 142:193-207 (1996).

O5212 Ondansetron HCl dihydrate 100 mgC18H29N3O.HCl.2H2O FW 365.86 [99614-01-4] 500 mgA serotonin-3 (5-HT3) receptor antagonists, used to prevent radiosurgery-induced nausea and

vomiting and modulation of alcohol intoxiccation.

Seynaeve C, Verweij J, de Mulder PH. Anticancer Drugs. 2:343-55 (1991).

Swift RM, Davidson D, Whelihan W, Kuznetsov O. Biol Psychiatry. 40:514-21 (1996).

N

N N

N

NH

HO

NH

CH3

N

N

SS

S

CH3

HN

NOH3C

S

O

CH2 N

H3C

OCH3

CH3

N

O

N N

HClH2O2

OH

HO

O

O

OH

O

O

HO

O OH

H

H

OH

H

OH

HO

O

O

OH

O

O

HO

O OH

H

H

OH

H

O

OH

R

OHO O

OH

O

O

O

OR

R

OHR

R

N

N

O

O

HO

Na OH

O

O

Na


O6132 Opioid receptor antagonist Ac-RFMWMK-NH2 1 mgC44H66N12O7S2 FW 939.2

O6805 Orbifloxacin 100 mgC19H20F3N3O3 FW 395.38 [113617-63-3] 500 mgOrbifloxacin is a fluoroquinolone antibiotic that is active against some gram positive 5 gand gram negative bacteria.

Ganiere JP, Medaille C and Etore F Res Vet Sci. 77:67-71 (2004).

O7116 Orexin-B, human 1 mgHypocretin-2

C123H212N44O35S FW 2899.4A hypothalamic neuropeptide encoded by a single mRNA transcript that stimulates food intake.Lee JH, Bang E, Chae KJ et al. Eur J Biochem. 266:831-9 (1999).

O6953 Ornidazole 5 gTiberal, Madelen 50 gC7H10ClN3O3 FW 219.63 [16773-42-5]Used to treat some protozoan infections.Khrianin AA, Reshetnikov OV Antibiot Khimioter. 51:18-21 (2006).

O7053 L-Ornithine Hydrochloride 10 gC5H12N2O2

.HCl FW 168.62 [3184-13-2] 25 gA nonprotein amino acid. It is used in the body in the biosynthesis of L-arginine, 100 gL-proline and polyamines. 1 kgBarbul A. J Parenter Enteral Nutr. 10:227-238 (1986).

Wasaki K, Mano K, Ishihara M et al. Biochem Int. 14:971-976 (1987).

Orphanin FQ (See Nociceptin)

O7218 Oseltamivir Phosphate 10 mgC16H31N2O8P FW 410.4 [204255-11-8] 25 mgAn oral anti-viral drug for the treatment of uncomplicated influenza one year 100 mgor older. Approved by the FDA to treat type A or B influenza.

Rayner, C. R. Journal of Clinical Pharmacology (2008), 48(8), 935-947.

Johnson, D. S. Art of Drug Synthesis (2007), 95-114.

O7377 Osthole 250 mgC15H16O3 FW 244.29 [484-12-8] 1 gA coumarin isolated from Cnidium monnieri (L.) Cusson. It is an antiplatelet 5 g agent that inhibits phosphoinositide breakdown. It also prevents anti-Fas

antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway.

Teng CM, Ko FN, Wang JP et al. J Pharm Pharmacol. 43:667-9 (1991).

Okamoto T, Kawasaki T, Hino O. Biochem Pharmacol. 65:677-81 (2003).

O8503 OVA(323-339) 5 mgC74H120N26O25 FW 1773.9

O8500 Ovalbumin(257-264) antigen peptide 1 mgC45H74N10O13 FW 963.2

O O

CH3H3C

H3CO

HO NH2

O

NH2

N

N

O2N CH3

OH

Cl

Ac-Arg-Phe-Met-Trp-Met-Lys-

NH2

Arg-Ser-Gly-Pro-Pro-Gly-Leu-

Gln-Gly-Arg-Leu-Gln-Arg-Leu-

Leu-Gln-Ala-Ser-Gly-Asn-His-

Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

Ile-Ser-Gln-Ala-Val-His-Ala-Ala-

His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-

Arg

Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu

O

O

CH3

H2N

NH

OCH3

CH3

H3C

O

HOP

O

OHOH

N N

NH

OO

HO

F

F

F


O9302 Oxacillin Sodium Monohydrate 1 gC19H18N3NaO5S.H2O FW 441.44 [7240-38-2] 5 gA member of the penicillin class of antibiotics. 25 gKirby WM, Rosenfeld LS, Brodie J. JAMA. 181:739-44 (1962).

O9201 Oxaliplatin 5 mgC8H14N2O4Pt FW 397.29 [61825-94-3] 25 mgA novel platinum analogue which has wide spectrum anti-cancer activity. It is 100 mg found to be more active against human melanoma cell lines, and has better

biochemical, pharmacological and cytotoxic properties than cisplatin and carboplatin.

Cassidy J. Int J Clin Pract. 54:399-402 (2000).

Mohammed MQ, Retsas S. Anticancer Drugs. 11:859-63 (2000).

O9210 Oxcarbazepine 1 gC15H12N2O2 FW 252.27 [28721-07-5] 5 gA second-generation antiepileptic drug. It inhibits CYP2C19 and induces 25 gCYP3A4 and CYP3A5 systems. Studies suggest that the anticonvulsant

activity of oxcarbazepine is mediated via the blocking of neuronal ion channels.

Carrazana E, Mikoshiba I. J Pain Symptom Manage. 25:S31-5 (2003).

Bang L, Goa K. Paediatr Drugs. 5:557-73 (2003).

O9322 Oxfendazole 10 gC15H13N3O3S FW 315.35 [53716-50-0] 25 gAn anthelmintic agent. 100 gCorwin RM. Am J Vet Res. 38:465-7 (1977).

O9334 Oxibendazole 5 gC12H15N3O3 FW 249.27 [20559-55-1] 10 gAn anthelmintic agent. It has been shown to be effective in killing Trichinella 25 gspiralis in mice, and histotrophic larvea and adult parasites in calves.

Karunakaran CS, Denham DA. J Parasitol. 66:929-32 (1980).

Theodorides VJ, DiCuollo CJ, Nawalinski T et al. Am J Vet Res. 38:809-14 (1977).

O9234 Oxiconazole Nitrate 1 gC18H14Cl4N4O4 FW 492.15 [64211-46-7] 5 gAn antifungal agent. 25 gPolak A. Arzneimittelforschung. 32:17-24 (1982).

O9256 16-Oxocafestol 25 mgC18H24O2 FW 284.40 m.p. 168-1720C [108664-99-8] 50 mgSynthetic derivative of cafestol. 100 mg

500 mg

O9257 16-Oxokahweol 10 mgC19H22O2 FW 282.39 m.p. 180-1830C [108664-99-9] 25 mgSynthetic derivative of kahweol. 50 mg

100 mg

N

O

O NH2

O

O

O

O

Cl

Cl

ON

N

N

Cl

Cl

HNO3

N

HN

O

NHCOCH3

O

H3C

S N

HN

O

NH

H3CO

O

NH2

NH2O

OO

O

Pt

N

S

H H

NH

COONa

CH3

CH3ON

O CH3

O


O9458 Oxolinic acid 5 gC13H11NO5 FW 261.23 [14698-29-4] 25 gA quinolone antibiotic agent that inhibits the enzyme DNA gyrase. Also may act as

a dopamine reuptake inhibitor.

DiCarlo, F.J., et al. Arch. Biochem. Biophys. 127: 503-511 (1968).

O9596 Oxybutynin HCl 250 mgC22H31NO3

.HCl FW 393.95 [1508-65-2] 1 gIt competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic

acetylcholine receptor.

Tupker RA, Harmsze AM, Deneer VH (2006). Arch Dermatol 142 (8): 1065–6.

O9398 Oxymetazoline Hydrochloride 5 gC16H24N2O.HCl FW 296.84 [2315-02-8] 25 gAn α-adrenoceptor stimulant.

Sanders J, Miller DD, Patil PN. J Pharmacol Exp Ther. 195:362-71 (1975).

O9396 Oxytetracycline 10 gC22H24N2O9 FW 460.43 [79-57-2] 50 gAn antibiotic. It impairs mitochondrial protein synthesis resulting in 100 gproliferation arrest in s.c. and Zajdela tumor cells. Zajdela mitochondrial tumor

cells cease dividing after a few generations, which is preceded by reduction of cytochrome c oxidase

activity of the tumor cells.

van den Bogert C, Dontje BH, Wybenga JJ et al. Cancer Res. 41:1943-7 (1981).

Kroon AM, Dontje BH, Van den Bogert C. Cancer Res. 43:2247-51 (1983)

O9397 Oxytetracycline Hydrochloride 10 gC22H24N2O9

.HCl FW 496.93 [2058-46-0] 50 g100 g

O9497 Oxytocin 5 mgC43H66N12O12S2 FW 1007.2 [50-56-6] 25 mgOxytocin has shown the ability to induce contractions and milk production in rats 100 mgPederson C, Prange Ar. PNAS 76(12); 6661-6665 (1979) 1 g

O9702 Ozagrel HCl 10 mgC13H13ClN2O2 FW 264.71 [82571-53-7] 25 mgAn antiplatelet agent working as a thromboxane A2 synthesis inhibitor. 100 mgLoo MH, Egan D, Vaughan ED, Marion D, Felsen D, Weisman S (March 1987). J. Urol. 137 (3): 571–6.

P0001 P1 0.5 mgC39H63N11O13 FW 894.0 1 mg

2.5 mg

P0013 P7C3 5 mgC21H18Br2N2O FW 474.2 [301353-96-8] 25 mgExerts proneurogenic activity by protecting newborn neurons from apoptosis.

Prolonged administration to aged rats impedes neuronal death and preserves

cognitive capacity.Peiper AA, et al Cell 2010 142:39.

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-

Leu-Gly-NH2


H-Gly-Ser-Phe-Leu-Val-Arg-

Glu-Ser-OH

OH O OH O

NH2

OHH H

OH NCH3HO

CH3H3C

OHO

OH O OH O

NH2

OHH H

OH NCH3HO

CH3H3C

OHO

.HCL

OH

NH

N

HCl

NN

O

OH

HCl

NH

OH

N

Br Br

N O

O

O

HO

O

ON

CH3

CH3OH

O

HCl


P0055 P55-TNFR 1 mgC57H95N15O22 FW 1342.48 2 mg

5 mg

P0075 P75-TNFR 1 mgC53H85N15O156S1 FW 1204.42 2 mg

5 mg

P0005 PACAP (1-27), human, ovine, rat 0.5 mgC142H224N40O39S1 FW 3147.68 [127317-03-7] 1 mg

2.5 mg

P0006 PACAP (1-38), human, ovine, rat 0.5 mgC203H331N63O53S1 FW 4534.36 [124123-15-5] 1 mg

2.5 mg

P0007 PACAP (6-27), human, ovine, rat 0.5 mgC203H331N63O65S FW 4534.4 1 mg

2.5 mg

P0008 PACAP(6-38), human, ovine, rat 0.5 mgPituitary adenylate cyclase activating peptide 1 mgC203H331N63O65S FW 4534.4 [137061-48-4] 2.5 mgA hypothalamic peptide that affects anterior pituitary cell function. It also plays

a key role in the embryogenesis of brain, protection of brain nerve cells from

ischemia-induced death, injuring and apoptosis.

Chepurnov SA, Chepurnova NE, Ponomarenko AA et al. Usp Fiziol Nauk. 30:3-20 (1999).

Arbogast LA, Voogt JL. Brain Res. 655:17-24 (1994).

P0009 PACAP 38, frog 0.5 mgC204H333N63O53S FW 4548.38 1 mg

2.5 mg

P0010 PACAP-Related Peptide (PRP), human 0.5 mgC139H229N41O42 FW 3146.62 1 mg

2.5 mg

P0011 PACAP-Related Peptide (PRP), rat 0.5 mgC148H242N42O45S1 FW 3361.9 1 mg

2.5 mg

H-Ser-Met-Ala-Pro-Gly-Ala-

Val-His-Leu-Pro-Gln-Pro-OH

H-His-Ser-Asp-Gly-Ile-Phe-

Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-

Arg-Lys-Gln-Met-Ala-Val-Lys-

Lys-Tyr-Leu-Ala-Ala-Val-Leu-

NH2

H-His-Ser-Asp-Gly-Ile-Phe-

Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-

Arg-Lys-Gln-Met-Ala-Val-Lys-

Lys-Tyr-Leu-Ala-Ala-Val-Leu-

Gly-Lys-Arg-Tyr-Lys-Gln-Arg-

Val-Lys-Asn-Lys-NH2

H-Leu-Pro-Gln-Ile-Glu-Asn-

Val-Lys-Gly-Thr-Glu-Asp-OH

His-Ser-Asp-Gly-Ile-Phe-Thr-

Ap-Ser-Tyr-Ser-Arg-Tyr-Arg-

Lys-Gln-Met-Ala-Val-Lys-Lys-

Tyr-Leu-Ala-Ala-Val-Leu-Gly-

Lys-Arg-Tyr-Lys-Gln-Arg-Val-

Lys-Asn-Lys-NH2

H-Phe-Thr-Asp-Ser-Tyr-Ser-

Arg-Tyr-Arg-Lys-Gln-Met-Ala-

Val-Lys-Lys-Tyr-Leu-Ala-Ala-

Val-Leu-NH2

H-Asp-Val-Ala-His-Glu-Ile-Leu-

Asn-Glu-Ala-Tyr-Arg-Lys-Val-

Leu-Asp-Gln-Leu-Ser-Ala-Arg-

Lys-Tyr-Leu-Gln-Ser-Met-Val-

Ala-OH

H-Asp-Val-Ala-His-Gly-Ile-Leu-

Asn-Glu-Ala-Tyr-Arg-Lys-Val-

Leu-Asp-Gln-Leu-Ser-Ala-Gly-

Lys-His-Leu-Gln-Ser-Leu-Val-

Ala-OH

H-His-Ser-Asp-Gly-Ile-Phe-Thr-

Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-


Tyr-Leu-Ala-Ala-Val-Leu-Gly-

Lys-Arg-Tyr-Lys-Gln-Arg-Ile-

Lys-Asn-Lys-NH2


P0092 Paclitaxel, (Natural), 99% (See page 6 for more info) 1 mgC47H51NO14 FW 853.91 m.p. 213-2160C [33069-62-4] 5 mgNatural diterpenoid isolated from the stem bark of the Pacific yew tree 25 mg(Taxus brevifolia Nutt.). It promotes the assembly of stable microtubules and inhibits 100 mgthe disassembly process of microtubules to tubulin.

Wani MC, Taylor HL, Wall ME et al. J. Am. Chem. Soc. 93:2325 (1971).

SuffnessM,CordellGA.Antitumor Alkaloids.In:TheAlkaloids.ChemistryandPharmacology,Brossi

Ed.; Acad Pr: N Y, Vol. XXV, pp. 3-355 (1985).

Manfredi JJ, Horwitz SB. Pharmacol. Ther. 25:83 (1984).

P0093 Paclitaxel (Semi-synthetic) 5 mgC47H31NO14 FW 853.9 25 mgA natural diterpenoid originally isolated from the stem bark of Taxus brevifolia. 100 mg It promotes the assembly of stable microtubules and inhibits the disassembly process of microtubules to tubulin by calcium ions and by low temperature. Taxol was shown to have activity against cancers, such as P388 and L1210 leukemia, B16 melanoma, WM-256 carcinosarcoma, Sarcoma 180, Lewis lung tumor, and several xenografts of human tumors

including MX-1 mammary, LX-1 l

Wani, M. C., Taylor, H. L., Wall, M. E., Coggon, P., McPhail, A. T. J. Am. Chem. Soc. 93:2325 (1971).

P0218 Paeoniflorin 1 mgC23H28O11 FW 480.46 [23180-57-6] 5 mgPaeoniflorin is a glycoside isolated from the root of Paeonia lactiflora. It has 10 mgbeen used as an anticonvulsant and has hypoglycemic effect. It reverses guanethidine-

induced hypotension by activating the central adenosine A1 receptors in the brain. Abel-Hafez AA, Meselgy MR, Nakamura N et al.Chem.Pharm.Bull (Tokyo).46:1486-1487 (1998).

Hsu FL, Lai CW, Cheng JT. Planta Med. 63:323-325 (1997).

Cheng JT, Wang CJ, Hsu FL. Clin. Ecp. Pharmacol Physiol. 26:815-816 (1999).

P0219 Paeonol 1 gC9H10O3 FW 166.17 [552-41-0] 5 gActive ingredient isolated from Paeonia suffruticosa Andr. Its pharmacologic

functions include anti-inflammatory, antiaggregatory, and anti-ischemia reperfusion damage and anti-lipid peroxidation effects.Harada M, Yamashita A, Aburada M. J Pharm Soc Japan 92:750-756 (1972).

Hirai A, Terano T, Hamazaki T et al. Throm Res. 31:29-40 (1983).

Zhang WG, Zhang ZS. Acta Pharm Sinica 29:145-148 (1994).

P0144 Paliperidone 25 mgC23H27FN4O3 FW 426.48 [144598-75-4] 100 mgIt is indicated in the treatment of schizophrenia, as well as manic and mixed 500 mgepisodes occurring in conjunction with Bipolar I Disorder, and depression.

Narasimhan, M. Expert Review of Clinical Pharmacology (2008), 1(6), 737-744.

Marino, J. Pharmacotherapy (2008), 28(10), 1283-1298.

P0245 Palmatine Chloride Hydrate 1 gC21H22NO4

.Cl.xH2O FW 387.86 [171869-95-7] 5 gPalmatine is a protoberberine alkaloid isolated from medicinal herbs such as 10 g Coptis chinensis Franch. It is a selective toposomerase I and II poison. The sedative

effect of palmatine is related to its ability to inhibit dopamine biosynthesis.

Palmatine is a vasodilator that reduces [Ca2+].Sanders MM, Liu AA, Li TK et al. Biochem. Pharmacol. 56:1157-1166 (1998).

Pilch DS, Yu C, Makhey D et al. Biochemistry. 36:12542-12553 (1997).

Shin JS, Kim EI, Kai M, Lee MK. Neurochem. Res. 25:363-368 (2000).

Hsieh MT, Su SH, Tsai HY et al. Jpn. J.Pharmacol. 61:1-5 (1993).

Chang YL, Usami S, Hsieh MT, Jiang MJ. Life Sci. 64:597-606 (1999).

N

H3CO

H3CO

Cl

OCH3

OCH3

xH2O

O

HO

O

N

O

N

N

N

O

OH

F

H O

OH

O

H

H

OHH

OH

CH2OH

H

O

O

HC

CH3

OH

H2

COC

O

O

OH

O CH3

O

H

OH

OO

O

O

OH

NH

O OCH3

O

O

3'2'

1'

19

17 20

18

1612

15

14

13

11 10 9

87 6

54

3

21

O

OH

O CH3

O

H

OH

OO

O

O

OH

NH

O OCH3

O

O

3'2'

1'

19

17 20

18

1612

15

14

13

11 10 9

87 6

54

3

21


P0145 Palmitoyl-D,L-carnitine Chloride 100 mgC23H45NO4

.HCl FW 436.07 [6865-14-1] 500 mgA specific protein kinase C inhibitor. It inhibits 12-O-tetra decanoyl-phorbol-13-acetate (TPA)

enhanced transformation in BALB/3T3 cells.

Semba M, Ini N. Toxicol Lett. 51:7-12 (1990).

P0146 Palmitoyl-L-carnitine Chloride 5 mgC23H45NO4

.HCl FW 436.1 [18877-64-0] 10 mgProtein kinase inhibitor.

Butler AP, Mar PK, McDonald FF, Ramsay RL. Exp Cell Res. 194:56-61 (1991).

P0049 Pamidronate Disodium 10 mgC3H9NNa2O7P2

.5H2O FW 369.11 [109552-15-0] 50 mgCalcium metabolism regulator. 100 mgMan Z, Otero AB, Rendo P et al. Lancet. 335:663 (1990).

Fitton A, McTavish D. Drugs. 41:289-318 (1991).

P0253 Panaxadiol 5 mgC30H52O3 FW 460.74 [19666-76-3] 10 mgSapogenin isolated from Panax ginseng. 25 mg

P0254 Panaxatriol 5 mgC30H52O4 FW 476.73 [32791-84-7] 10 mgSapogenin isolated from Panax ginseng. 25 mg

P0350 Pancreatic Polypeptide, avian 0.5 mgC190H283N53O58 FW 4237.69 [58591-52-9] 1 mg

2.5 mg

P0351 Pancreatic Polypeptide, rat 0.5 mgC195H298N58O57S FW 4398.9 [90419-12-8] 1 mgA gut hormone released from the pancreas in response to ingestion of food. It 2.5 mghas been found to cause a sustained decrease in both appetite and food intake.

Batterham RL, Le Roux CW, Cohen MA et al. J Clin Endocrinol Metab. 88:3989-92 (2003).

P0353 Pancreatic Polypeptide, human 0.5 mgC185H287N53O54S2 FW 4181.7 [75976-10-2] 1 mg

2.5 mg

P0352 Pancreastatin, porcine 0.5 mgC214H330N68O76S FW 5103.4 1 mgA regulatory peptide with a general inhibitory effect on secretion. Inhibits 2.5 mgDNA and protein synthesis by producing NO in HTC rat hepatoma cells, and modulates insulin signaling in rat.Gonzalez-Yanes C, Sanchez-Margalet V. Diabetes. 49:1288-94 (2000).

Sanchez-Margalet V, Gonzalez-Yanes C, Najib S. J Hepatol. 35:80-5 (2001).

H

OH

CH3CH3 H

H

HO

CH3

H

CH3

CH3 OH

O

H

OH

CH3CH3 H

H

HO

H3C

H

CH3

CH3

O

H2N

HO

P

OOH

ONa

P

O ONa

OH

5H2O

Gly-Trp-Pro-Gln-Ala-Pro-Ala-

Met-Asp-Gly-Ala-Gly-Lys-Thr-

Gly-Ala-Glu-Glu-Ala-Gln-Pro-

Pro-Glu-Gly-Lys-Gly-Ala-Arg-

Glu-His-Ser-Arg-Gln-Glu-Glu-

Glu-Glu-Glu-Thr-Ala-Gly-Ala-

Pro-Gln-Gly-Leu-Phe-Arg-Gly-

NH2

H-Gly-Pro-Ser-Gln-Pro-Thr-Tyr-

Pro-Gly-Asp-Asp-Ala-Pro-Val-

Glu-Asp-Leu-Ile-Arg-Phe-Tyr-

Asp-Asn-Leu-Gln-Gln-Tyr-Leu-

Asn-Val-Val-Thr-Arg-His-Arg-

Tyr-NH2

H-Ala-Pro-Leu-Glu-Pro-Val-

Tyr-Pro-Gly-Asp-Asn-Ala-Thr-

Pro-Glu-Gln-Met-Ala-Gln-Tyr-

Ala-Ala-Asp-Leu-Arg-Arg-Tyr-

Ile-Asn-Met-Leu-Thr-Arg-Pro-

Arg-Tyr-NH2

Ala-Pro-Leu-Glu-Pro-Met-Tyr-Pro-

Gly-Asp-Tyr-Ala-Thr-His-Glu-Gln-

Arg-Ala-Gln-Tyr-Glu-Thr-Gln-Leu-

Arg-Arg-Tyr-Ile-Asn-Thr-Leu-Thr-

Arg-Pro-Arg-Tyr-NH2

N

O

OH

O

O

Cl

13

N

O

OH

O

O

Cl

13


P0252 Pancuronium Bromide (See page 21 for more info) 10 mgC35H60Br2N2O4 FW 732.67 [15500-66-0] 50 mgA muscle relaxant which acts as a competitive acetycholine antagonist on 100 mgneuromuscular junctions. 250 mgStankov-Jovanovic, V. Analytical and Bioanalytical Chemistry (2006), 385(8), 1462-1469.

Delogu, G. Acta Anaesthesiologica Scandinavica (2003), 47(9), 1138-1144.

P0255 Pantoprazole (See page 27 for more information) 100 mgC16H15F2N3O4S FW 383.37 [102625-70-7] 500 mgA proton pump inhibitor. Inhibits vesicular gastric H+/K(+)-ATPase under acid 1 gtransporting conditions by accumulating in the acid space generated by the pump.

It has an inhibitory effect on acid secretion. Krusekopf S, Roots I, Hildebrandt AG et al. Xenobiotica. 33:107-18 (2003).

Shin JM, Besancon M, Simon A et al. Biochim Biophys Acta. 1148:223-33 (1993).

P0256 Pantoprazole Sodium 1 gC16H14F2N3NaO4S. 3/2H2O FW 432.37 [138786-67-1] 5 gAntiulcerative. 25 g

P0260 Papain Inhibitor 5 mgC19H29N7O6 FW 451.49 [70195-20-9] 10 mg

25 mg

P0268 Parasin I 0.5 mgC82H154N34O24 FW 2000.36 1 mg

2.5 mg

P0269 Parathyroid Hormone (1-34), bovine 0.5 mgTeriparatide 1 mgC183H288N54O50S2 FW 4108.7 [12583-68-5] 2.5 mgA hormone shown to increase bone mass in a variety of animals and humans with osteoporosis.

Frolik CA, Black EC, Cain RL et al. Bone. 33:372-9 (2003).

P0370 Paromomycin Sulfate 1 gC23H45N5O14

.H2SO4 FW 713.71 [1263-89-4] 5 gA aminoglycoside antibiotic. 25 gKonno T, Takahashi T, Muto A et al. Nucleic Acids Res Suppl. (3):235-6 (2003).

Lando D, Cousin MA, Ojasoo T et al. Eur J Biochem. 66:597-606 (1976).

P0297 Paroxetine Hydrochloride 100 mgC19H20FNO3

.HCl.1/2H2O FW 374.84 [110429-35-1] 500 mgA potent selective 5-hydroxytryptamine reuptake inhibitor used as a treament of 1 gmajor depression.

Johnson AM. Int. Clin. Psych. 6:Suppl 4:5-24 (1992).

P0270 Parthenolide 25 mgC15H20O3 FW 248.32 [20554-84-1] 100 mgSesquiterpene lactone and active ingredient of feverfew. Anti-inflammatory 250 mgagent. Induces apoptosis and cell necrosis. Suppresses NF-kappaB activity.

Pozarowski P et al Cytometry 54:118-124 (2003).

Wen J et al J. Biol. Chem. 277:38954-38964 (2002).

O

ONH2

OH

H2N

O

O

OH

HO

HO

HO

OHO

O

NH2

HO

H2N

HO

NH2

. H2SO4

HN

F

O

O

O

.HCl.1/2H2O

N

HN

N

OF

F

O

H3CO

OCH3

O

O

H2CH

H O

H3C

CH3

H-Gly-Gly-Tyr-Arg-OH

H-Lys-Gly-Arg-Gly-Lys-Gln-

Gly-Gly-Lys-Val-Arg-Ala-Lys-

Ala-Lys-Thr-Arg-Ser-Ser-OH

Ala-Val-Ser-Glu-Ile-Gln-Phe-

Met-His-Asn-Leu-Gly-Lys-His-

Leu-Ser-Ser-Met-Glu-Arg-Val-

Glu-Trp-Leu-Arg-Lys-Lys-Leu-

Gln-Asp-Val-His-Asn-Phe

N

O

CH3O

CH3

H

H

H

CH3

H

O

CH3

O

N

CH3

H3C

2Br

N

NS

N

H3CO

OCH3

OF

F

O

Na

3/2 H2O


P0278 Patulin 1 mgClavacin, clavatin, penicidin 5 mgC7H6O4 FW 154.12 [149-29-1] 10 mgProduced by a number of fungi species of Aspergillus and Penicillium. It has anti-bacterial, carcinogenic and mutagenic activities. Birkinshaw M et. Al. Lancet 245:625 (1943).

Dickens Brit. Med. Bull. 20:96 (1964).

P0392 Paxilline 5 mgC27H33NO4 FW 435.56 [57186-25-1] 10 mgA tremorgenic indole alkaloid that selectively blocks

high-conductance Ca2+-activated K+-channels.

Sanchez M et al Neuropharmacology 35:963 (1996).

Young C et al Curr. Genet. 33:368 (1998).

P0397 Pazopanib (See page 29 for more information) 5 mgC21H23N7O2S FW 437.53 [444731-52-6] 25 mgA potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1,

VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and

inhibits angiogenesis.Sleijfer S, Ray-Coquard I, Papai Z, et al. J. Clin. Oncol. 27:3126-3132 (2009).

P0398 Pazufloxacin Mesylate (See page 16 for more info) 500 mgC16H15FN2O4

.CH3SO3H FW 414.41 [163680-77-1] 1 gA fluoroquinolone antimicrobial agent. It has a broad spectrum of activity 5 gand potent activity against gram-positive and gram-negative bacteria.

Fukuoka Y, Ikeda Y, Yamashiro Y et al. Antimicrob Agents Chemother. 37:384-92 (1993).

Muratani T, Inoue M, Mitsuhashi S. Antimicrob Agents Chemother. 36:2293-303 (1992).

P1200 PD184352 5 mgC17H14ClF2IN2O2 FW 478.66 [212631-79-3] 25 mgA potent and selective inhibitor of MEK, a key component of the Mitogen activated 100 mgprotein kinase (MAPK) cascade. It has been found to induce apoptosis, has

antiproliferative and antitumor activities.

Pohl, G., et al. Cancer Res. 65: 1994-2000 (2005)

RR Mattingly et al. J. Pharmacol. Exp. Ther. 2006, 316, 456-465.

D Liu et al. J. Clin. Endocrinol. & Meta. 2007, 92 (12), 4686-4695.

P1202 PD325901 5 mgC16H14F3IN2O4 FW 482.19 [391210-10-9] 25 mgA potent inhibitor of MEK, a key component of the Mitogen activated protein kinase 100 mg(MAPK) cascade. It has been found to inhibit tumor cell growth, has antiangiogenic

and antiproliferative activities.

Barret, S.D., Bridges, A.J., Dudley, D.T., et al. Bioorg Med Chem Lett 18: 6501-6504 (2008).

Ciuffreda L, Del Bufalo D, Desideri M, et al. Neoplasia, 11:720-731, (2009).

P1622 Pefloxacine Mesylate 5 g Pefloxacine Methansulfonate dihydrate 25 gC17H20FN3O3

.CH3SO3H.2H2O FW 465.50 [149676-40-4] 100 gA fluoroquinolone antimicrobial agent. It was found to inhibit cell growth of normal hematopoietic progenitor cells and leukemic cell lines. Kondo H, Sakamoto F, Kawakami K, Tsukamoto G. J Med Chem. 31:221-5 (1988).

Somekh E, Douer D, Shaked N, Rubinstein E. J Pharmacol Exp Ther. 248:415-8 (1989).

N

N

H3C

N

F

O

COOH

CSO3H

2H2O

CH3

O

O

OH

O

HN

S

N

N

NH2

O

O

N

N

N

HN

O

CH3

CH3

OH

O

H3C

OH

H3C

HN

F

F

NH

O

O

Cl I

NH

F

F

I

F

NH

O

O OH

OH

N

OCH3

F

O

COOH

H2N

CH3SO3H


P1849 Pemetrexed 100 mgC20H19N5Na2O6 FW 471.37 [150399-23-8] 250 mgIs a chemotherapy drug used for the treatment of pleural mesothelioma as well 1 gas non-small cell lung cancer.Hanauske, Axel-R, European Journal of Cancer (2008), 44(16), 2444-2452

P1754 Penciclovir 100 mgC10H15N5O3 FW 253.26 [39809-25-1] 500 mgNucleoside analog that blocks DNA replication. 1 gShaw T, Amor P, Civitico G, Boyd M, Locarnini S. Antimicrob Agents Chemother. 38:719-23 (1994).

Earnshaw DL, Bacon TH, Darlison SJ et al. Antimicrob Agents Chemother. 36:2747-57 (1992).

P1753 Penicillamine 1 gC5H11NO2S FW 149.21 [52-67-5] 5 gExogenous NOS modulator, found to inhibit urease activity. 25 gChen JX, Berry LC, Tanner M, et al. J Cell Physiol.186:116-23 (2001).

Sissons CH, Yakub S. Oral Microbiol Immunol. 15:317-324 (2000).

P1854 Penicillic acid 5 mgC8H10O4 FW 170.16 [90-65-3] 10 mgAnibiotic mycotoxin produced by various strains of Penicillium and Aspergillu. 50 mgIt has been found in corn and tabacco. Induces DNA single-strand breaks.Keblys M, Bernhoft A, Hofer CC, Morrison E, Larsen HJ, Flaoyen A Mycopathologia 158:317-24 (2004)

P1852 Penicillin G procaine 10 gC29H38N4O6S.H2O FW 588.73 [6130-64-9] 25 gSemisynthetic antibiotic. 100 g

P1853 Penicillin V Potassium 10 gC16H17KN2O5S FW 388.48 [132-98-9] 25 gA bactericidal against penicillin-susceptible microorganisms during the stage of 100 g active multiplication. It produces its effect by inhibiting biosynthesis of cell-wall mucopeptide.Spitzer TQ. Harris BA. South Med J. 70:41-2 (1977).

Bolme P, Eriksson M. Acta Paediatr Scand. 65:253-6 (1976).

P1952 Penitrem A 1 mgTremortin A 5 mgC37H44ClNO6 FW 634.20 [12627-35-9]A tremorgenic indole alkaloid. Inhibits high-conductance Ca2+-activated K+ channels.

Knaus HG Biochemistry 33:5819-5828 (1994).

P1955 Pentagastrin 1 mgC37H50N7O9S1 FW 768.79 [5531-95-2] 2 mg

5 mg

P1755 Pentoxifylline 10 gC13H18N4O3 FW 278.31 [6493-05-6] 50 gA vasodilator that has potential as radiation sensitizer. It is capable of 100 gstimulating drug induced apoptosis in leukemic cells.Johnson FE, Harrison BR, McKirgan LW et al. Int J Oncol. 13:801-5 (1998).

P1764 Pep-1 0.5 mgC37H50N7O9S1 FW 768.79 1 mg

2.5 mg

NH

N

S

O

CH3

CH3

COOH

HHO

ON CH3

H2N

OCH3

OHN

N

S

H H

O

O

CH3

CH3

COO K

HN

N N

N

H2N

O

OH

OH

COOHH3C

H3C

SH

NH2

Boc-beta-Ala-Trp-Met-Asp-Phe-

NH2

H-Lys-Glu-Thr-Trp-Trp-Glu-

Thr-Trp-Trp-Thr-Glu-Trp-Ser-

Gln-Pro-Lys-Lys-Lys-Arg-Lys-

Val-OH

N

N

N

N

CH3

CH3

O

O

H3C

O

H2C

NH

O

H

OH

Cl

O

H3C

CH3

OH

H

OOH

HCH2

CH3

CH3H3C

O

OH

O

H3CO

H2C CH3

O

NH

NH

HN

NH2N

O

O

ONa

ONaO


P1765 Peptide Standard 1 0.5 mgC98H144N25O26S2 FW 2152.52 1 mg

2.5 mg

P1766 Peptide B, bovine 0.5 mgC163H239N39O53S2 FW 3657.08 1 mg

2.5 mg

P1767 Peptide F, bovine 1 mgC163H239N39O53S2 FW 3657.08 2 mg

5 mg

P1760 Peptide T 1 mgC35H55N9O16 FW 857.86 [106362-32-7]A potent HIV cell entry inhibitor. Acts by blocking chemokine-5 receptors (CCR5).

Polianova MT, Ruscetti FW, Pert CB et al. Peptides. 24(7): 1093-1098 (2003).

P1763 Peptide YY, human 1 mgC194H295N55O57 FW 4309.8 [118997-30-1] 2 mgAn appetite inhibiting protein secreted by the intestine. 5 mgButler MG, Bittel DC, Talebizadeh Z. J Ped Endocrinology. 17(9):1177-1184 (2002).

P1762 Peptide YY, porcine 1 mgC190H288N54O57 FW 4240.7 [81858-94-8] 2 mg

5 mg

P1768 Peptide YY(3-36), PYY, human 0.5 mgC180H279N53O54 FW 4049.55 [123583-37-9] 1 mg

2.5 mg

P1761 Pepstatin 5 mgC34H63N5O9 FW 685.89 [26305-03-3] 25 mgAn inhibitor of acid proteases isolated from streptomyces. It has been shown to 100 mg induce contractile effects on rat aorta rings.Petrescu G, Costuleanu M, Slatineanu SM et al. Rev Med Chir Soc Med Nat Iasi. 106:741-5 (2002).

Guyene TT, Devaux C, Menard J et al. J Clin Endocrinol Metab. 43:1301-6 (1976).

P1770 Perillyl Alcohol 10 gC10H16O FW 152.23 [18457-55-1] 50 gA monoterpene derived from Lavender, that induces apoptosis in colon tumor cells. Inhibits

mammary cancer by inducing hepatocyte phase II enzymes, glutathione-S-transferase.Reddy BS, Wang CX, Samaha H et al. Cancer Res. 57:420-425 (1997).

Gould MN. Environ Health Perspect. 105 (Suppl 4):977-979 (1997).

P1869 Perindopril Erbumine (See page 25 for more information) 100 mgC19H32N2O5

. C4H11N FW 441.60 [107133-36-8] 250 mgA potent angiotensin converting enzyme inhibitor used for antihypertensive 1 gtherapy. Yamamoto Y, Oiwa K, Hayashi M, Ohara T, Muranishi M. Hypertens Res. 28:571-8 (2005).

Ajayi AA, Lees KR, Reid JL. Eur J Clin Pharmacol. 30: 177-82 (1986).

H3CHN

NH

HN

NH

HN

CH3 O

H3C CH3

O

O

CH3

CH3

O

O

OH CH3

CH3

COOH

CH3

OH

H3C CH3

H-Cys-Pro-Asp-Phe-Gly-His-

Ile-Ala-Met-Glu-Leu-Ser-Val-

Arg-Thr-Trp-Lys-Tyr-OH

Ala-Ser-Thr-Thr-Thr-Asn-Tyr-

Thr

Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-

Gly-Glu-Asp-Ala-Ser-Pro-Glu-

Glu-eu-Asn-Arg-Tyr-Tyr-Ala-Ser-

Leu-Arg-His-Tyr-Leu-Asn-Leu-

Val-Thr-Arg-Gln-Arg-Tyr-NH2

Tyr-Pro-Ala-Lys-Pro-Glu-Ala-Pro-

Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-

Leu-Ser-Arg-Tyr-Tyr-Ala-Ser-Leu-

Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-

Arg-Gln-Arg-Tyr-NH2

H-Tyr-Gly-Gly-Phe-Met-Lys-Lys-

Met-Asp-Glu-Leu-Tyr-Pro-Leu-

Glu-Val-Glu-Glu-Glu-Ala-Asn-

Gly-Gly-Glu-Val-Leu-Gly-Lys-

Arg-Tyr-Gly-Gly-Phe-Met-OH

H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-

Glu-Asp-Ala-Ser-Pro-Glu-Glu-

Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-

Leu-Arg-His-Tyr-Leu-Asn-Leu-

Val-Thr-Arg-Gln-Arg-Tyr-NH2

H-Cys-Pro-Asp-Phe-Gly-His-Ile-

Ala-Met-Glu-Leu-Ser-Val-Arg-

Thr-Trp-Lys-Tyr-OH

N

ONH

H

H

O O

O

OH

NH2

CH2OH


P2445 PGLa 1 mgC88H162N26O22S FW 1968.5 [102068-15-5]An antimicrobial peptide isolated from frog skin, which exerts its activity by permeabilizingbacterial membranes.da Silva A Jr, Teschke O. Biochim Biophys Acta. 1643:95-103 (2003).

Wieprecht T, Apostolov O, Beyermann M et al. Biochemistry. 39:442-52 (2000).

P2303 Phallacidin 1 mgC37H50N8O13S FW 846.91 [26645-35-2] 5 mgA actin filament stabilizer isolated from Amanita phalloides. It differs fromPhalloidin in that it contains a carboxy group for coupling reactions.Papakonstanti EA, Stournaras C. Mol Biol Cell. 15:1273-86 (2004).

Sampson K, Pickett-Heaps JD. Protoplasma. 217:166-76 (2001).

P2304 Phalloidin 1 mgC35H48N8O11S FW 788.87 [17466-45-4] 5 mgAn actin filament stabilizer isolated from Amanita phalloides.

Dubin M, Maurice M, Feldmann G et al. Gastroenterology. 75:450-5 (1978).

Thamilselvan V, Basson MD. Gastroenterology. 126:8-18 (2004).

P2400 Phenethyl caffeate (See page 10 for more information) 50 mgCaffeic acid phenethyl ester, CAPE 100 mgC17H16O4 FW 284.31 [104594-70-9] 500 mgActive ingredient of honeybee hive products, propolis. Cytotoxic agent against

cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase.

Grunberger D, Banerjee R, Eisinger K et al. Experientia 44:230-232 (1988).

Rao CV, Desai D, Kaul B, Amin S et al. Chem. Biol. Interactions 84:277-290 (1992).

P2410 Phenethyl dimethyl caffeate (See page 10 for more info) 50 mgC19H20O4 FW 312.37 M.P. 97-980C [14551-14-0] 100 mgInhibitor of ornithine decarboxylase and protein tyrosine kinase. 500 mgRao CV, Desai D, Kaul B et al. Chem. Biol. Interactions 84:277-290 (1992).

P2502 Phenethyl glucosinolate potassium salt, 97% 5 mgC15H19NO9S2K FW 460.55 [499-30-9] 10 mgOne of the numerous glucosinolates widely distributed in cruciferus vegetables. 100 mgSynthetic potassium salt of gluconasturtiin.

P2508 Phenethyl isothiocyanate, 98% (See page 8 for info) 5 g2-Isothiocyanatoethylbenzene 10 gC9H9NS FW 163.24, b.p.113oC/1mm [2257-09-2] d. 1.094 50 gInhibitor of NNK-induced lung tumorigenesis.Jiao D, Smith TJ, Yang CS et al. Carcinogenesis. 11:2143-2147 (1997).

Phenethyl isothiocyanate N-acetyl-L-cysteine conjugateSee N-acetyl-S-(N'-phenethylthiocarbamoyl)-L-cysteine

P2512 S-(N-Phenethylthiocarbamoyl)-L-cysteine 10 mgC12H16N2O2S2 FW 284.40 25 mgA cysteine conjugate of phenethyl isothiocyanate. 100 mg

CH2CH2 C

S

NOSO3K

O

OH

OHHO

HO

(CH2)2NCS

Gly-Met-Ala-Ser-Lys-Ala-Gly-

Ala-Ile-Ala-Gly-Lys-Ile-Ala-Lys-

Val-Ala-Leu-Lys-Ala-Leu-NH2

NH

H2C

HC C

HN C

HC

NH

HC

C

NH

O

S

CH2

CH

HN C CH

C

OH

H3C CH2OH

CH3

O

OHC CH3

OH

C

O

HN

N

C

NH

CH

C

OH

CH2

O

H3C

OO

O

O

HO

HO

O

O

O

O

NH2

S

O

OHNH

S

NH

S

H2CCH

HN

HC C

HN CH C

NH

C

OO

H3C

CH2

NH

O

O

HC

C

NH

CH

O

C CH2OH

OH

H3C

N C

O

CH

H2C

OH

HN C

HC

HC

OH

COOHO

CH3

CH3


P2514 S-(N-Phenylbutylthiocarbamoyl)-glutathione 5 mg(See page 8 for more information) 10 mgC21H30N4O6S2 FW 498.62 25 mgA glutathione conjugate of phenylbutyl isothiocyanate.

P2516 S-(N-Phenylbutylthiocarbamoyl)-L-cysteine 10 mgC14H20N2O2S2 FW 312.45 25 mgA cysteine conjugate of phenylbutyl isothiocyanate. 100 mg

P2522 S-(N-Phenylthiocarbamoyl)-glutathione 5 mg(See page 8 for more information) 10 mgC17H22N4O6S2 FW 442.51 25 mgA glutathione conjugate of phenyl isothiocyanate.

P2817 Phentolamine Hydrochloride 50 mgC17H19N3O.HCl FW 317.81 [73-05-2] 100 mgα-Adrenergic blocker. 500 mgMeier R et al. Proc Soc Exp Biol Med 71:70 (1949).

P2818 Phentolamine mesylate 50 mgC17H19N3O.CH3SO3H FW 377.46 [65-28-1] 100 mgα-Adrenergic blocker. Used to treat male erectile dysfunction. 500 mgMcMahon CG. Int J Impot Res. 8:233-6 (1996).

P2919 L-Phenylalaninol 1 g(S)-(-)-2-Amino-3-phenyl-1-propanol 5 gC9H13NO FW 151.21 [3182-95-4] 25 gIt inhibits ulcer formaiton by the reduction of gastric acid secretion.

Hashizume H, Miyamae T, Morikawa T, Hagiwara M. Chem Pharm Bull (Tokyo). 40:3113-4 (1992).

P2810 Phenylbutazone 25 gC19H20N2O2 FW 308.37 [50-33-9] 100 gA non steroidal anti-inflammatory drug (NSAID). Several lines of evidence suggest that NSAID

may be effective in preventing colorectal cancer. Phenylbutazone lowers the incidence of pancreatic

carcinoma in experimental animals treated with N-nitrosobis (2-oxopropyl) amine.

Hixson LJ, Alberts DS, Krutzsch et al. Cancer Epidemiol Biomarkers Prev. 3:433-8 (1994).

Takahashi M, Furukawa F, Toyoda K et al. Carcinogenesis. 11:393-5 (1990).

P2510 4-Phenylbutyl isothiocyanate (See page 8 for more info) 1 gC11H13NS FW 191.31 [61499-10-3] d. 1.006 5 gA synthetic phenyl alkyl isothiocyanate that has been found to induce Phase II 10 gdetoxifying enzymes. It also inhibits chemically induced carcinogenesis.Morse M A, Eklind K I, Amin SG et al. Carcinogenesis. 10:1757-1759 (1989).

Wilkinson JT, Morse .A et al. Carcinogenesis 16:1011-1015 (1995).

P2815 Phenylbutyrate 1 g4-Phenylbutyric acid sodium salt 5 gC10H11O2 FW 186.18 [1716-12-7] 25 gAn aromatic fatty acid that induces cytostasis, differentiation and apoptosis in primary myeloid leukemic cells, human prostate cancer cell lines and human colon carcinoma cells. It also has chemopreventive effects against chemically induced colon carcinogenesis in experimental animals.Digiuseppe JA, Weng LJ, Yu KH et al. Leukemia. 13:1243-53 (1999).

Ng AY, BAles W, Veltri RW. Anls Quant Cyto Histol. 22:45-54 (2000).

Huang Y, Horvath CM, Waxman S. Cancer Res. 60:3200-6 (2000).

Wargovich MJ, Jimenez A, Mc kee K et al. Carcinogenesis. 21:1149-55 (2000).

O

O

Na +

H2N OH

CH3

N

OH

CH3SO3H

N

NH

NN

O

O

CH3

N

N

HN

OH

HCl

O NH

OH

O

SNH

NH2

OH

OOHN

S

NH2

S

O

OHNH

S

O NH

OH

O

SNH

NH2

OH

OOHN

S

(CH2)4NCS


P1917 Phenylethyl 3-methylcaffeate 50 mgC18H18O4 FW 298.33 [71835-85-3] 100 mgIt has chemopreventive property against chemically induced colon 500 mgcarcinogenesis,and enhances apoptosis in azoxymethane induced colon tumors.

Rao CV, Desai O, Rivenson A et al. Cancer Res. 55: 2310-5 1 (1995).

Samaha HS, Kelloff G J, Steele V et al. Cancer Res. 57:1301-5 (1997).

P2918 Phenylethyl 4-methylcaffeate 25 mgC18H18O4 FW 298.33 50 mg

250 mg

P2819 6-Phenyl-hexa-3,5-dien-2-one 5 mgC12H12O FW 172.22 [4173-44-8] 10 mgA minor component of kava kava extract.

P2922 Phenylhexyl isothiocyanate (See page 8 for info) 100 mgC13H17NS FW 219.35 [133920-06-6] 250 mgChemopreventive agent in mouse lung. Found to enhance colon and esophageal 500 mgtumorigenesis in the rat.

Morse MA, Eklind KI, Hecht SS. et al. Cancer Res. 51:1846-50 (1991).

Rao CV, Rivenson A, Simi B et al. Cancer Res. 55:4311-8 (1995).

Stoner GD, Siglin JC, Morse MA et al. Carcinogenesis. 16:2473-6 (1995).

P2513 Phenyl isothiocyanate 50 gPhenyl mustard oil, PITC 100 gC7H5NS FW 135.19 b.p. 2210C [103-72-0] d. 1.130Inhibitor of NNK-induced lung tumorigenesis.Jiao D, Smith TJ, Yang CS et al. Carcinogenesis. 11:2143-2147 (1997).

P2515 3-Phenylpropyl isothiocyanate (See page 8 for info) 5 gC10H11NS FW 177.27 [2627-27-2] d. 1.070 10 gSynthetic phenyl isothiocyanate that has been found to induce Phase II detoxifying enzymes. It also inhibits chemically induced carcinogenesis.Morse M A, Eklind K I, Amin SG et al. Carcinogenesis. 10:1757-1759 (1989).

Benson AM, Barretto PB. Cancer Res. 45:4219-4223 (1985).

Sparnins VL, Chuan J, Wattenberg LW. Cancer Res. 42:1205-1207 (1982).

Morse MA, Amin SG, Hecht SS, Chung FL. Cancer Res 49:2894-2897 (1989).

Wilkinson JT, Mors MA, Kresty LA, Stoner GD. Carcinogenesis. 16:1011-1015 (1995).

P2816 S-(N-3-Phenylpropylthiocarbamoyl)-L-cysteine 100 mgC13H18N2O2S2 FW 298.42 m.p. 202-2080C [137915-13-0] 500 mg(See page 8 for more information) 1 gCysteine conjugate of phenylpropyl isothiocyanate.

P2832 PHI, porcine 1 mgC136H216N36O40 FW 2995.39 [80458-29-3]Peptide hisitidine isoleucine has been shown to induce an anorexigenic response in rats.

It also plays a critical role in the generation of circadian oscillations.

P2833 PHI, rat 0.5 mg

C136H216N36O41 FW 3011.45 [96849-38-6] 1 mg2.5 mg

NH

C

S

C

S

NH2

OH

O

(CH2)3

His-Ala-Asp-Gly-Val-Phe-Thr-

Ser-Asp-Phe-Ser-Arg-Leu-Leu-

Gly-Gln-Leu-Ser-Ala-Lys-Lys-

Tyr-Leu-Glu-Ser-Leu-Ile-NH2

H-His-Ala-Asp-Gly-Val-Phe-

Thr-Ser-Asp-Tyr-Ser-Arg-Leu-

Leu-Gly-Gln-Ile-Ser-Ala-Lys-

Lys-Tyr-Leu-Glu-Ser-Leu-Ile-

NH2

(CH2)6NCS

NCS

(CH2)3NCS

O

O

O

HO

O

O

O

O

HO


P2845 Phleomycin 5 mgC51H75N17O21S2 FW 1326.38 [11006-33-0] 25 mgA glycopeptide antibiotic from the bleomycin family. It catalyzes double- 100 mgstrand breaks in DNA.He CH, Masson JY, Ramotar D. Can J Microbiol. 42:1263-6 (1996).

Nakada D, Shimomura T, Matsumoto K et al. Nucleic Acids Res. 31:1715-24 (2003).

P2856 Phorbol-12,13-dibutyrate 1 mgC30H46O8 FW 504.61 [37558-16-0] 5 mgPKC activator.

Less potent than TPA.

P2857 Phorbol-12-myristate-13-acetate 1 mg12-Tetradecanoyl phorbol 13-acetate, TPA 5 mgC36H56O8 FW 616.83 [16561-29-8]A very potent promoter of carcinogenesis. Binds to and activates protein kinase C.

Blumberg PM. Crit. Rev. Toxicol. 8:153-197 (1980).

P2858 4-α-Phorbol-12-myristate-13-acetate 1 mgC36H56O8 FW 616.83 [63597-44-4] 5 mgAn inactive negative control for TPA.

Van Duuren BL, Tseng SS, Segal A et al. Cancer Res. 39:2644-2646 (1979).

P2859 Phosphate Acceptor Peptide 1 mgC41H74N16O11 FW 967.15 2 mg

5 mg

P2992 Phyllolitorin 0.5 mgC49H69N11O11S1 FW 1020.24 [87734-77-8] 1 mg

2.5 mg

P2993 Phyllomedusin 1 mgC52H82N16O13S1 FW 1171.41 [26145-48-2] 2 mg

5 mg

P2994 Physalaemin 1 mgC56H84N14O16S1 FW 1265.48 [2507-24-6] 2 mg

5 mg

P2995 Physcion 10 mgC16H12O5 FW 284.26 [521-61-9] 25 mgA anthraquinone isolated from Rheum emodi with antifungal and 100 mgantitumor activity.

Agarwal SK, Singh SS, Verma S et al. J Ethnopharmacol. 72:43-6 (2000).

Kuo YC, Sun CM, Ou JC et al. Life Sci. 61:2335-44 (1997).

P2997 Phytic Acid, 40-50 wt% aqueous solution 100 mlInositol hexaphosphate 500 mlC6H18O24P6 FW 660.04 [83-86-3]A constituent of wheat bran shown to have antineoplastic action in colon

carcinogenesis. Inhibits cell proliferation and increases cell differentiation.

Sakamoto K, Venkatraman G, Shamsuddin AM. Carcinogenesis 14:1815-1819 (1993).

H-Arg-Arg-Lys-Ala-Ser-Gly-

Pro-Pro-Val-OH

pGlu-Asn-Pro-Asn-Arg-Phe-

Ile-Gly-Leu-Met-NH2

pGlu-Leu-Trp-Ala-Val-Gly-Ser-

Phe-Met-NH2

pGlu-Ala-Asp-Pro-Asn-Lys-Phe-

Tyr-Gly-Leu-Met-NH2

OHOOH

O

H3C OCH3

CH2OH

HO

H

O

H3C

O

H

OH

H3C

O

H

CH3

CH3

O

C13H27O

CH3

O

H

H

OH

H

CH3

H

CH3

HO

HO

H

O

CH2OH

H

OC3H7

C3H7

O

CH3

H3C

N N

H2N

CH3

HNH2N

O

NH2

O

NH2

HN

O

NH

O CH3 CH3 HN

OO CH3

NH

O

OH

ON

NH

N

S

N S

H2N OO

O

HO

HO

H3C

HO

O

OH

HOOH

OH

H2N O

OO

O

O

O O

R

R

R

R

R

R

R = PO3H2

O

H

H

OH

H

CH3

H

CH3

HO

H

O

H

O

CH2OH

H

OC3H7

C3H7

O

CH3

H3C


P3209 Piceatannol 5 mgC14H12O4 FW 244.24 [10083-24-6] 25 mgA naturally occurring resveratrol analog. Inhibits nonreceptor

kinases Syk and Lyk. Stimulates Sirt1.

CJ Seow et al Eur. J. Pharmacol. 2002 443:189.

KT Howitz et al Nature 2003 425:191.

Piceid (See Polydatin)

P3210 Picoplatin 5 mgC6H7N.Pt.Cl2

.NH3 FW 376.15 [181630-15-9] 10 mgA new generation organic platinum analog with an extended spectrum of 25 mgantineoplastic activity. Designed to overcome platinum drug resistance, picoplatin

alkylates DNA, forming both inter- and intra-strand cross-linkages, resulting in inhibition

of DNA replication and transcription, and the induction of apoptosis.

Tang CH, Parham C, Shocron E, et al. Cancer Chemother. Pharmacol. 67:1389-1400 (2011).

P3313 Pidotimod 1 gC9H12N2O4S FW 244.27 [121808-62-6] 5 gA biological response modifier. It inhibits apoptosis induced by several agents, 10 g including genistein.

Migliorati G, Nicoletti I, Riccardi C. Arzneimittelforschung. 44:1421-4 (1994).

Gourgiotis D, Padaopoulos NG, Bossios A et al. J Asthma. 41:285-7 (2004).

Pimaricin (See Natamycin)

P3348 Pimecrolimus 5 mgC43H68ClNO11 FW 810.45 [137071-32-0] 25 mgBelongs to the ascomycin class of macrolactam immunosuppressives, acting by the

inhibition of T-cell activation by the calcineurin pathway and inhibition of the release

of numerous inflammatory cytokines, thereby preventing the cascade of immune and

inflammatory signals.

Allen BR, Lakhanpaul M, Morris A, et al. Arch Dis Child 88 (11):969–973 (2003).

P6954 Pioglitazone Hydrochloride (See page 18 for info) 100 mgC19H20N2O3S.HCl FW 392.91 [112529-15-4] 500 mgOrally active antihyperglycemic agent effective as treatment of non-insulin- 1 gdependent diabetes mellitus. It inhibits cholesterol absorption and shows

anti-inflammatory and anti-arterioscleortic effects.

Ikeda H, Taketomi S, Sugiyama Y et al. Arzneimittel-Forschung 40:156-162 (1990).

Colca JR, Dailey CF, Palazuk BJ et al. Diabetes 40:1669-1674 (1991).

Ishibashi M, Egashira K, Hiasa K et al. Hypertension. 40:687-693 (2002).

P3462 Piperacillin 1 gC23H27N5O7S FW 517.56 [61477-96-1] 5 gA semisynthetic penicillin with broad spectrum of antimicrobial activity. 10 gJones RN, Thornsberry C, Barry AL et al. J Antibiot (Tokyo). 30:1107-14 (1977).

P3463 Piperacillin sodium 1 gC23H26N5NaO7S FW 539.54 [59703-84-3] 5 g

10 gN

S

H H

NH

COONa

CH3

CH3O

OHNN

O

NO

O

H3C

N

S

H H

NH

COOH

CH3

CH3O

OHNN

O

NO

O

H3C

N O

NH

SO

O

.HCl

HNO

N

S

O COOH

O

O

N

O

O

O

O

O

OH HOH

H

O

Cl

OH

HO

OH

OH

OH

Pt

Cl

Cl

NH3

N


P3465 Piperine (See page 5 for more information) 1 gC17H19NO3 FW 285.34 [94-62-2] 5 gAn alkaloid from black pepper. It shows chemopreventive, cytotoxic, anti-inflammatory,

and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by modulating

lipid peroxidation and augmenting antioxidant defense system.

Sunila ES, Kuttan G. J Ethnopharmacol. 90:339-46 (2004).

Selvendiran K, Senthilnathan P, Magesh V et al. Phytomedicine. 11:85-9 (2004).

Mittal R, Gupta RL. Methods Find Exp Clin Pharmacol. 22:271-4 (2000).

P3568 Pirarubicin 5 mgC32H37NO12 FW 627.64 [72496-41-4] 10 mgAn analogue of the anthracycline anti-neoplastic doxorubicin. Pirarubicin 25 mg intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication.Kudo K. J. Clin. Oncol. 25(34):5442-7 (2007).

P3269 Piroxicam 1 gC14H11N3O4S FW 317.32 m.p. 198-2000C [36322-90-4] 5 gA non-steroidal anti-inflammatory agent proven to be an effective 10 gchemopreventive in colon and urinary bladder carcinogenesis models.Reddy BS. Prev.Med. 25:48-50 (1996).

Okajima E, Ozono S, Endo T et al. Jpn. J. Cancer Res. 88:543-552 (1997).

P3576 Pitavastatin Calcium 10 mgC50H46F2N2O8Ca FW 880.98 [147526-32-7] 25 mgLike the other statins, it is an inhibitor of HMG-CoA reductase, the enzyme that 100 mg catalyses the first step of cholesterol synthesis.

Yamazaki, H., Journal of Atherosclerosis and Thrombosis (2006), 13(6), 295-307.

P3592 Pixantrone Dimaleate 10 mgC25H27N5O10 FW 557.51 [144510-96-3] 25 mgA synthetic anthracene-9,10-dione that has ant-itumor activity. It is also considered 100 mga promising immunosuppressant agent for treatment of multiple sclerosis.

Zwelling LA, Mayes J, Altschuler E, et al Biochem Pharmacol 46:265-71 (1993).

Cavaletti G, Cavalletti E, Crippa L, et al. J Neuroimmunol 151:55-56 (2004).

P3597 Pizotyline malate 1 gPizotifen malate 5 gC19H21NS.C4H6O5 FW 429.54 [5189-11-7] 10 gA serotonin receptor antagonist used as an antimigraine. It has shown venoconstrictor activity in vivo.Muller-Schweinitzer E. J Cardiovasc Pharmacol. 8:805-10 (1986).

Cleland PG, Barnes D, Elrington GM et al. Eur Neurol. 38:31-8 (1997).

P4008 PKC412 1 mgMidostaurin; 4'-N-Benzoyl staurosporine 5 mgC35H30N4O4 FW 570.64 [120685-11-2]Tyrosine kinase inhibitor being studied in the treatment of cancer. Cell permeable

inhibitor of protein kinases, including protein kinase C.Moellgard, L. Cancer Chemotherapy and Pharmacology (2008), 62(3), 439-448.

P4403 Plasminogen Activator Inhibitor 1 (PAI-1) 0.5 mgC27H47N9O9S FW 673.79 1 mg

2.5 mg

P4560 PLP (139-151) 1 mgProteolipid protein 5 mgC72H104N20O17 FW 1521.7

H-Ala-Arg-Met-Ala-Pro-Glu-

OH

His-Ser-Leu-Gly-Lys-Trp-Leu-

Gly-His-Pro-Asp-Lys-Phe

N N

NH

O

O

NCH3

O

H3C

CH3H

CH3

O

S

N

CH3

.C4H6O5

SN

H

OO

CONH

N

OH

O

OOCH3

OH

OOH

OH

OH

O

O

O

NH2

CH3

O

O

ON

O

N

OH OH

F

O

O

2

Ca2+

N

O

O

NH

NH

H2N

H2N

OHOO

OHOHOO

OH


P5712 Podophyllotoxin 50 mgC22H22O8 FW 414.41 m.p. 114-1180C [518-28-5] 100 mgAn antineoplastic agent that inhibits microtubule assembly. 500 mgRoach MC et al. J. Biol. Chem. 260:3015 (1985).

P5845 Polydatin 250 mgResveratrol 3-b-mono-D-glucoside, Piceid 1 gC20H22O8 FW 390.38 [65914-17-2]A natural product from Polygonum cuspidatum, found to posses prophylactic and therapeutic

effects. Polydatin has been shown to inhibit ICAM-1 expression in endothelial cells stimulated by lipopolysaccharide.Zhao KS, Jin C, Huang X et al. Clin Hemorheol Microcirc. 29:211-7 (2003).

Shu SY, Wang XY, Ling ZY et al. Chin J Traumatol. 7:239-43 (2004).

P5878 Potassium canrenoate 1 gCanrenoic acid potassium salt 5 gC22H29KO4 FW 396.56 [2181-04-6] 25 gAn aldosterone antagonist, antiarrhythmic and diuretic drug. It has been found to produce genotoxic effects in cultured rat and human cells.Martelli A, Mattioli F, Carrozzino R et al. Mutagenesis.14:463-72 (1999).

Marchetti G, Vitolo E, Di Francesco GF et al. Arch Int Pharmacodyn Ther. 266:250-63 (1983).

P5885 Povidone iodine 50 gFW 364.94 [25655-41-8] 100 gA topical antiseptic.

Flynn J. Br J Community Nurs. 8:S36-42 (2003).

P6232 PP1 5 mgC16H19N5 FW 281.36 [172889-26-8] 25 mgPotent and selective inhibitor of Src family tyrosine kinases. Cell permeable.

JH Hanke et al J. Biol. Chem 271:695 (1996).

P6901 Pramipexole Dihydrochloride 10 mgC10H17N3S.2HCl.H2O FW 302.26 [191217-81-9] 25 mgIs a medication for treating Parkinson’s disease and restless leg syndrome. 100 mgA non-ergoline dopamine agonist. Arbouw, M. E. L. European Journal of Clinical Pharmacology (2008), 64(10), 1021-1026.

P6802 Pranoprofen 100 mgC15H13NO3 FW 255.27 [52549-17-4] 250 mgA non-steroidal antiinflammatory drug inhibits platelet aggregation. 1 gGoto, K. Mikashima, H., Terasawa, M.et al J. Pharm Soc. Japan 97:1211-1215 (1977).

P6903 Prasugrel 100 mgC20H20FNO3S FW 373.44 [150322-43-3] 250 mgIs a member of the thienopyridine class of ADP receptor inhibitors 1 gBaker WL, White CM. American Journal of Cardiovascular Drugs 9 (4): 213-229 (2009).

P6800 Pravastatin Lactone 10 mgC23H34O6 FW 406.51 [85956-22-5] 50 mgPravastatin lactone is an antihyper- lipoproteinemic. 100 mgO'Neil, M. (ed.) The Merck Index, 13th ed. Merck & Co. Inc. Whitehouse Station, NJ 2001.

H

O

H

CH3

OH3C

CH3H

OH

O

HO

O

N O

COOH

CH3

N

CH

O

H2

C

n

OH

O

HH

HCH3

CH3

O

OK

OH

CC

H

H

OH

OO

CH2OH

OH

OH

OH

O

OO

O

OH

OCH3

H3CO OCH3

H3C

O

O

S

NO

H

F

N

NN

N

NH2

N

S

NH2

HN

2HCl H2O


P6801 Pravastatin Sodium (See page 26 for more information) 10 mgC23H35NaO7 FW 446.51 [81131-70-6] 50 mgBiologically active metabolite of mevastatin, HMG-CoA reductase inhibitor. 100 mg

Raasch RH. DICP. 25:388-394 (1991).

Egashira K, Hirooka Y, Kai H et al. Circulation. 89:2519-24 (1994).

P7103 Praziquantel 1 gC19H24N2O2 FW 312.41 [55268-74-1] 5 gAn anthelmintic that is highly effective against all Schistosoma species. 25 gPearson RD, Guerrant RL. Ann. Internal Med. 99:195-198 (1983).

P6818 Prednisolone 1 gC21H28O5 FW 360.4 [50-24-8] 5 gA glucocorticoid with anti-inflammatory and immuno-suppressive activity in 10 g rabbits. It induces apoptosis in colon cancer cell lines and eosinophils. Research results show that predinisolone in combination with TNP-470 may be a very effective drugfor angiosarcoma treatment.Meng RD, El-Deiry WS. Exp Cell Res. 262: 154-169 (2001).

Fan GK, Itoh T, Imanaka Met al. J Allergy Clin Immunol.106: 551-8 (2000).

Ma G, Masuzawa M, Hamada Y et al. J Dermatol Scie. 24:126-33 (2000).

P7012 Prednisolone sodium phosphate 5 gC21H27Na2O8P FW 484.39 [125-02-0] 10 gWater soluble form of prednisolone. 25 g

P7020 Prednisone 1 gC21H26O5 FW 358.43 [53-03-2] 5 gAn anti-inflammatory adrenocortical steroid used to treat Crohn's disease. It 25 g reduces intestinal permeability, mucosal TNF-a production and levels of NF-kB expression.

Wild GE, Waschke KA, Bitton A, Thomson AB. Aliment Pharmacol Ther. 18:309-17 (2003).

P7021 Prednisone Acetate 1 gC23H28O6 FW 400.46 [125-10-0] 5 g

25 g

P7023 Pregnenolone (See page 21 for more information) 5 g5-Pregnen-3b-ol-20-one 25 gC21H32O2 FW 316.48 [145-13-1] 100 gAn endogenous neurosteroid inhibits GABA-gated chloride currents by enhancing receptordesensitization. It modulates NMDA receptors resulting in delayed apoptotic retinal cell death. It stimulates prostate LNCaP cell proliferation through binding to the mutated androgen receptor.Shen W, Mennerick S, Covey DF, Zorumski CF. J Neurosci. 20:3571-9 (2000).

Cascio C, Guarneri R, Russo D et al. J Neurochem. 74:2380-91(2000).

Grigoryev DN, Long BJ, Njar VC, Brodie AH. J Steroid Biochem Mol Biol. 75:1-10 (2000).

P7022 Pressinoic Acid 1 mgC33H42N8O10S2 FW 774.08 [35748-51-7] 2 mg

5 mg

H

NaOOC

HO

H

CH3

OH3C

CH3H

OH

O

HO

O

CH3

HOCH3

C O

CH2OH

OH

N

N

O

O

O

CH3

O

CH3

C O

CH2OCOCH3

OH

HH

H

O

CH3

OH3C

HH

H

OH

OOH

Gly-Met-Ala-Ser-Lys-Ala-Gly-

Ala-Ile-Ala-Gly-Lys-Ile-Ala-Lys-

Val-Ala-Leu-Lys-Ala-Leu-NH2

OH

CH3

CH3C

O

CH3

O

CH3

HOCH3

C O

OH

O P

O

ONa

ONa


P7033 Primaquine phosphate 5 gC15H21N3O.2H3PO4 FW 455.29 [63-45-6] 10 gAn antimalarial drug with genotoxicity (Ames test) and 50 gcardiotoxicity (inhibitor of cardiac Na+ current).Chatterjee T, Muhkopadhyay A, Khan KA, Giri AK. Mutagenesis. 13:619-24 (1998).

Orta-Salazar G, Bouchard RA, Morales-Salgado F et al. Br J Pharmacol. 135 :751-63 (2002).

P7034 Prion Peptide (106-126), human 1 mgC80H138N26O24S2 FW 1912.28 [148439-49-0] 2 mg

5 mg

P6858 Procarbazine Hydrochloride 100 mgC12H19N3O.HCl FW 257.76 [366-70-1] 500 mgAntineoplastic agent. 1 gNewell D, Gescher A, Harland S et al. Cancer Chemother Pharmacol. 19:91-102 (1987).

P7056 Procaterol Hydrochloride 10 mgC16H22N2O3

.HCl FW 326.82 [59828-07-8] 25 mgA vasodialator used for the long term treatment of asthma. It is also a specific 100 mg and very potent B2 antagonist.

Yu, T.-W. Drug Development and Industrial Pharmacy (2006), 32(6), 651-660.

P6859 Proctolin 1 mgC30H48N8O8 FW 648.77 [57966-42-4] 2 mg

5 mg

P6854 Progesterone 5 gC21H30O2 FW 314.47 [57-83-0] 25 gA steroid hormone secreted by the corpus luteum. Maintains pregnancy, 100 gprevents ovulation.Sivaraman L, Medina D. J Mammary Gland Biol Neoplasia. 7:77-92 (2002).

P6850 Prolactin-Releasing Peptide (1-31), human 1 mgPrRP-31, human

C160H252N56O42S FW 3664.2

P6852 Propafenone Hydrochloride 1 gC21H27NO3

.HCl FW 377.91 [34183-22-7] 5 gAntiarrhythmic agent that has little or no beta-blocking property. It appears to to inhibit Ca++

inward current.Muller-Peltzer H, Greger G, Neugebauer G, Hollmann M. Eur J Clin Pharmacol. 25:831-3 (1983).

Harder DR, Belardinelli L. Experientia. 36:1082-3 (1980).

P6956 Prostaglandin E1 1 mgPGE1 5 mgC20H34O5 FW 354.48 [745-65-3] 10 mgOne of the primary prostaglandins, used as a vasodilator.Weir EK, Reeves JT, Grover RF. Prostaglandins. 10:623-31 (1975).

P6959 Prothionamide 1 gC9H12N2S FW 180.27 [14222-60-7] 5 gAn antibacterial used against Mycobacterium tuberculosis. 25 gUrbanczik R. Chemotherapy. 26:276-81 (1980).

O

HO

COOH

CH3

OH

N

S NH2

CH3

H-Lys-Thr-Asn-Met-Lys-His-

Met-Ala-Gly-Ala-Ala-Ala-Ala-

Gly-Ala-Val-Val-Gly-Gly-Leu-

Gly-OH

H-Arg-Tyr-Leu-Pro-Thr-OH

Ser-Arg-Thr-His-Arg-His-Ser-

Met-Glu-Ile-Arg-Thr-Pro-Asp-

Ile-Asn-Pro-Ala-Trp-Tyr-Ala-

Ser-Arg-Gly-Ile-Arg-Pro-Val-

Gly-Arg-Phe-NH2

O

NH

CH3

OH

O

.HCl

O

CH3

CH3

C O

CH3

H

H H

NH

O

OH

OH

NH

H3C

CH3

H3C

HCl

HN

NH

H3C

NH

CH3

O CH3

N

HNNH2

O

P

OH

OH

OH

O

2


P6857 Protocatechuic Acid 25 g3,4-Dihydroxybenzoic acid 50 gC7H6O4 FW 154.12 m.p. 200-2020C [99-50-3] 100 gA phenolic acid antioxidant present in fruits, vegetables and nuts.Found to be an efficacious chemopreventive agent in several carcinogenesis models.

Tanaka T, Kojima T, Kawamori T, Mori H. Cancer. 75:1433-1439 (1995).

P7060 Protocatechuic acid ethyl ester 5 gC9H10O4 FW 182.17 [3943-89-3] 25 gAn alkyl protocatechuate antioxidant found to display antioxidant, cardioprotective, 100 gneuroprotective, and anti microbial activity.

Raphael J, Rivo J, Beeri V, et al. Anesthesiology, 101: A717 (2004).

Roman M, Iveta H, Vladimir F et al. Czech J. Food Sci., 28: 275–279 (2010).

P7058 Protocatechuic Aldehyde 10 gC7H6O3 FW 138.12 [139-85-5] 25 gInduces apoptosis of human leukemia cells, as well as malignant HSG1 cells taken 100 g from human oral cavities.

Babich H, Sedletcaia A, Kenigsberg B (November 2002). Pharmacol. Toxicol. 91 (5): 245–253

P7057 Protodioscin 5 mgC50H82O22 FW 1049.19 [55056-80-9] 25 mgA steroidal saponin found in tribulus terrestris and other plants. It has been found to

trigger the release of nitric oxide in corpus cavernosum tissue and also produce

statistically significant increases in hormonal levels.

Adaikan PG, Gauthaman K, Prasad RN, Ng SC. Annals of the Academy of Medicine Singapore. 2000 Jan;29(1):22-6.

Gauthaman K, Ganesan AP. Phytomedicine. 2008 Jan;15(1-2):44-54.

P6957 Protopanaxadiol 5 mgC30H52O3 FW 460.73 [7755-01-3] 10 mgSame type saponins enhance axonal and dendritic formation activity. 25 mgIt was shown to possess characteristic effects on the proliferation of human leukemia cells.Popovich DG, Kitts DD. Arch Biochem Biophys. 406:1-8 (2002).

Tohda C, Matsumoto N, Zoo K, Meselhy MR, Komatsu K. Jpn J Pharmacol. 90:254-62 (2002).

P6958 Protopanaxatriol 5 mgC30H52O4 FW 476.73 [34080-08-5] 10 mgProtopanaxatriol may be an inhibitor of the uptake of glucose. 25 mgHan, H.; Park, S.; Koh, H., et al. Kidney Blodd Press. Res. 22: 114-120 (1999).

P7059 Proxymetacaine Hydrochloride 100 mgC16H26N2O3

.HCl FW 330.85 [5875-06-9] 250 mgis a local anesthetic that is used to numb the surface of a body part. 1 gPeyman G A; The British journal of ophthalmology (1994), 78(2), 138-41.

P7082 Prulifloxacin 25 mgC21H20FN3O6S FW 461.46 [123447-62-1] 100 mgA quinoline carboxilic acid antibioterial prodrug with activities against a variety 500 mgof Gram-positive and -negative bacteria. Shown to be an effective treatment for

urinary tract and respiratory tract infections.Matera MG. Pulm Pharmacol Ther. 19 (Suppl 1): 20-9 (2006).

Prats G, Rossi V, Salvatori E, Mirelis B. Expert Rev Anti Infect Ther. 4:27-41 (2006).

NS

N

N

CH3

O

O

O

F

O

OH

O

CH3

H

OH

CH3CH3 H

H

HO CH3

CH3

CH3

HO

H3CH

CH3

CH3 OH

CO2H

OH

HO

OH

OH

O H

OH H

H H

H

H OH

O

O

HO

HO

OHOH

O

O

OH

O

O

HOO

OH

HO

HO

O

OH

HO OH

H

OH

CH3CH3 H

H

HO CH3

CH3

CH3

HO

H3C

H

CH3

CH3

O

O

N

H2N

O

HCl

OH

HO

O

O


P7318 Pseudo ginsenoside F11 5 mgC48H82O19 FW 963.15 [69883-00-0] 10 mgA componet of Panax quinquefolium L. 25 mgAntagonized the memory dysfunction induced by scopolamine.

Li Z, Guo YY, Wu CF, Li X, Wang JH. J Pharm Pharmacol. 51:435-40 (1999).

P7219 Pseudolaric Acid B 1 mgC23H28O8 FW 432.46 [82508-31-4] 5 mgPseudolaric acid B (PAB) is a diterpene acid isolated from the bark of P. kaempferi,

a traditional Chinese medicinal plant.

Li, M., Miao, Z., Tan, W., et al. Clin Cancer Res 10 8266-8274 (2004).

P7358 Psoralen (Ficusin) (See page 32 for more info) 10 mgC11H6O3 FW 186.16 [66-97-7] 25 mgA furocoumarin found in several species of plant. Potent photosensitizing agent 100 mgknown to cause lethal and mutagenic effects in a wide range of organisms.

Ashwood-Smith MJ, Poulton GA, Barker M, et al. Nature 285:407-409 (1980).

P7359 Psoralidin 10 mgC20H16O5 FW 336.34 [18642-23-4] 25 mgProtein kinase Akt plays an important role in cell proliferation and survival in many 100 mgcancers, including prostate cancer. Inhibits apoptosis and promotes angiogenesis in

most cell types.

Raj Kumar,Cancer Prevention Research 2, 234, March 1, 2009.

P7628 pTH-Related Protein (1-34) (human, rat) 0.5 mgC180H287N57O48 FW 4017.65 [112540-82-6] 1 mg

2.5 mg

P8117 Puerarin, 99% 5 mgC21H20O9 FW 416.38 [3681-99-0] 10 mgA flavonoid derivative from the traditional oriental medicine, Ge-gen. 25 mgPurarin has potential antioxidant activity and impairs CYP catalyzed

drug metabolism. It's metabolite calycosin has cytotoxic activity.

Guerra MC, Speroni E, Broccoli M et al. Life Sci. 67: 2997-3006 (2000).

Kim DH, Yu Ku, Bae EA, Han M. J. Biol Pharm Bull. 21: 628-30 (1998).

P8118 Puerarin, 96% 100 mgC21H20O9 FW 416.38 [3681-99-0] 500 mg

1 g

P8168 Puromycin 10 mgC22H29N7O5 FW 471.51 [53-79-2] 25 mgAntibiotic substance produced by the soil actinomycete Streptomyces alboniger. 100 mgInhibitor of chemical carcinogenesis

Bonano E, Ruzittu M, Carla EC et al. Eur J Histochem. 44:237-46 (2000).

Huang P, Sandoval A, Van Den Neste E, Keating M J, Plunkett W. Leukemia. 14:1405-13 (2000).

H

OH

CH3CH3 H

H

HO

CH3

H

CH3

CH3

O

O

OH

O

OH

O

OH

CH2OH

O

OH

O

OH

CH3

OH

O

OH

OH

CH2HO

O

H OH

H

H

HOH

HO

HOO

O

OH

HO

O

H OH

H

H

HOH

HO

HOO

O

OH

HO

H-Ala-Val-Ser-Glu-His-Gln-

Leu-Leu-His-Asp-Lys-Gly-Lys-

Ser-Ile-Gln-Asp-Leu-Arg-Arg-

Arg-Phe-Phe-Leu-His-His-Leu-

Ile-Ala-Glu-Ile-His-Thr-Ala-OH

O OO

O

O OH

O

HO

O

O

O

O

OH

O

O

O

HO

N

N N

N

N(CH3)2

O

OHNH

HH

HH

O

H2NMeO


P8167 Puromycin aminonucleoside 25 mgStylomycin aminonucleoside 100 mgC12H18N6O3 FW 294.31 [58-60-6]Puromycin derivative that has antibiotic and antineoplastic properties, can cause nephrosis. Marshall CB, Pippin JW, Krofft RD, Shankland SJ Kidney Int. 70:1962-73 (2006).

Egashira Y, Nagaki S, Sanada H Int. J. Vitam. Nutr. Res. 76:28-33 (2006).

P8169 Purpurin 5 gC14H8O5 FW 256.21 m.p. 253-2560C [81-54-9] 25 gA xanthine oxidase inhibitor, which inhibits azoxymethane-induced

aberrant crypt foci in the rat.

Wargovich MJ, Chen CD, Jimenez A et al. Cancer Epidemiol. Biomarkers Prev 5:355-360 (1996).

Sheu SY, Chiang HC. Anticancer Res. 17:3293-3297 (1997).

P8270 Purvalanol A 1 mgC19H25ClN6O FW 388.89 [212844-53-6] 5 mgArrests cell cycle progression and induces apoptosis by inhibition of cyclin-dependent kinases.

Has shown antiviral and anticancer activity in several studies.

Wang L, Deng L, Wu K et al. Mol Cell Biochem. 237:137-153 (2002).

Villerbu N, Gaben AM, Redeuilh H et al. Int J Cancer. 97:761-769 (2002).

Kudoh A, Daikoku T, Sugaya Y. J Virol. 78:105-115 (2004).

Gray NS, Wodicka L, Thunnissen et al. Science. 281:533-538 (1998).

P8382 Puupehenone (See page 22 for more information) 1 mgC15H18O3 FW 246.30 5 mgMarine natural product isolated from sponges of the genus Hyrtios. Potential for

anticancer and antiinfective activity.

Zjawiony JK, Bartyzel P, Hamann MT. J. Nat. Prod. 61:1502-1508 (1998).

P9668 Pyrantel Pamoate 5 gC11H14N2S.C23H16O6 FW 594.69 [22204-24-6] 10 gAn anthelmintic. 50 gDesowitz RS, Bell T, Williams J, Cardines R, Tamarua M. Am J Trop Med Hyg. 19:775-8 (1970).

P9671 Pyrazinamide 10 gC5H5N3O FW 123.11 [98-96-4] 25 gAn antibacterial used in tuberculosis therapy often in combination with 100 grifampicin.Zhang Y, Mitchison D. Int J Tuberc Lung Dis. 7:6-21 (2003).

P6977 Pyr-Gly-Arg-pNA 1 mgC19H26N8O6 FW 462.5 10 mg

P9869 Pyridoxine Hydrochloride 25 gC8H12ClNO3 FW 205.64 [58-56-0] 100 g

A 4-methanol derivative of Vitamin B6.

P9767 Pyriproxyfen 5 gC20H19NO3 FW 321.37 [95737-68-1] 25 gA larvicidal agent that mimics juvenile hormone. Shown to prevent maturation 100 gof many species of insect.

Abo-Elghar GE, El-Shiekh AE, El-Sayed FM el al. Pest Manag Sci. 60:95-102 (2004).

Estrada JG, Mulla MS. J Am Mosquito Control Assoc. 2:314-320 (1986).

N O

CH3

O

O

Cl NH

N

NNH

N

N

H3C CH3

HO

CH3H3C

S

N

N

H3C

.C23H16O6

O

O

OH

OH

OH

N

NN

N

N

O

OHNH2

HO

CH3H3C

Pyr-Gly-Arg-pNA

N

HO

OH

OH

CH3

.HCl

N

N

NH2

O

O

O

O


P9768 Pyronaridine Tetraphosphate 100 mgC29H32ClN5O2

.4H3PO4 FW 900.1 [76748-86-2] 250 mgA widely used antimalarial agent that has been found to significantly enhance the 1 g antitumor activity of doxorubicin against multidrug-resistant cancers K562/A02 and MCF-7/ADR.Qi J, Wang S, Liu G et al. Biochem Bioph Res Comm. 319: 1124-1131 (2004).

Fu S, Bjorkman A, Wahlin B. Brit J Clin Pharmacol. 22: 93-96 (1986).

P9770 Pyrrolostatin 100 µgC15H21NO2 FW 247.33 [144314-68-1] 1 mgInhibits lipid peroxidation by scavenging free radicals.Kato S, Shindo K, Kawai H et al. J Antibiotics. 46:892-899 (1993).

Q4370 Q-K-R-P-S-Q-R-S-K-Y-L 1 mgC60H103N21O17 FW 1390.62 2 mg

5 mg

Q8016 Quercetin Dihydrate (See page 14 for more info) 25 gC15H10O7

.2H2O FW 338.26 [6151-25-3] 100 gA common flavonol, which inhibits lipoxygenase and ornithine decarboxylase induction. 500 gNakadate T, Aizu E, Yamamoto S, Kato R. Prostaglandins. 30:357-368 (1985).

Q8019 Quetiapine Fumarate 1 g2(C21H25N3O2S).C4H4O4 FW 883.09 [111974-72-2] 5 gIs a psychotropic agent belonging to a chemical class, the dibenzothiapines. 25 gUsed in the treatement of dementia related psychosis. It is proposed that the mechanism of action is through a dopamine type 2 and serotonin type 2 receptor. Cortese, L. Journal of Clinical Psychopharmacology (2008), 28(1), 69-73.

Q8133 Quinacrine Dihydrochloride Dihydrate 10 gC23H30ClN3O.2HCl.2H2O FW 508.92 [6151-30-0] 25 gA phospholipase A2 inhibitor. Showed synergistic inhibition of of prostate

cancer cells when used in combination with paclitaxel or lovastatin.de Souza PL, Castillo M, Myers CE. Br J Cancer. 75:1593-600 (1997).

Q8134 Quinapril Hydrochloride 100 mgC25H30N2O5

.HCl FW 474.99 [82586-55-8] 500 mgA firmly established and well tolerated angiotensin-converting enzyme inhibitor. 1 gIt attenuates the myocardial infarction induced rise in cardiac cytokine expression.Clinical trials show that quinapril prevents restenosis after coronary stenting in patients with angiotensin-coverting enzyme D allele.Warnica JW, Gilst WV, Baillot R, Johnstone D, Block P et al. Can J Cardiol. 18:1191-200 (2002).

We GC, Siroi MG, QuR, Liu P, Roulea JL. Cardiovasc Drugs Ther. 16:29-36 (2002).

Culy CR, Jarvis B. Drugs. 62:339-85 (2002).

Q8135 Quinestrol 100 mgEston, Estrovis, Plestrovis 250 mgC25H32O2 FW 364.52 [152-43-2] 1 gIt is used in estrogen replacement therapy.

Mann V, Huber C, Kogianni G, Collins F, Noble B Bone. 40:674-684 (2006).

R0105 Rabeprazole Sodium (See page 27 for more information) 10 mgC18H20N3O3S.Na FW 381.42 [117976-90-6] 25 mgA proton pump/ATP-ase inhibitor. 100 mgFuruta T, Shirai N, Sugimoto M et al. Pharmacogenomics. 5:181-202 (2004).

CH3

NH

HOOC

CH3 CH3

N

N OCH3

HN

Cl

OH

N

N

.4H3PO4

O

OOH

HO

OH

OH

OH

NCl

O

HN

N

2HCl

2H2O

H-Gln-Lys-Arg-Pro-Ser-Gln-

Arg-Ser-Lys-Tyr-Leu-OH

O

OH

HH

H

CH3

CH

NH

N

OCH3

H3C O

O

COOH

.HCl

N

N

S

O N

O O

Na

N

S

N

N

O

OH

OHO

O

2

HO


R0109 Racecadotril 100 mgC21H23NO4S FW 385.48 [81110-73-8] 500 mgA potent enkephalinase inhibitor exhibits selective antisecretory activity. 1 gPrimi MP, Bueno L, Baumer P et al. Ali. Pharm Ther. 13 suppl6:3-7 (1999).

Racemethorphan (See Dextromethorphan Hydrobromide)

R0110 Ractopamine HCl 1 g C18H23NO3

.HCl FW 337.84 [90274-24-1] 5 gAn adrenergic beta-Agonistsagonist with effects of increasing muscle mass and

decreasing body fat in rodents and lifestock.

Page et. al. Domest Anim Endocrinol. 26:23-31 (2004).

R0212 Radicicol 1 mgMonorden 5 mgC18H17ClO6 FW 364.78 [12772-54-5]Macrolactone antibiotic from several fungi. It has antifungal activity. It is a tyrosine kinase inhibitor, cell differentiation modulator, and has antiangiogenic activity.Shimada et al. J. Antibiot. 48:824 (1995).

Pillay et al. Cell Growth Differ. 7:1487 (1996).

Oikawa et al. Eur J Pharmacol. 241:221 (1993).

R0243 Raloxifene Hydrochloride 250 mgC28H27NO4S.HCl FW 510.05 [82640-04-8] 500 mgA selective estrogen receptor modulator (SERM. It is effective for the prevention 1 gof postmenopausal osteoporosis. It has been found to have caner chemopreventive activity in laboratory animals and antiproliferative effecs in human breast cancer.Anzano MA, Peer CW, Smith JM et al. J Natl Cancer Inst. 88:123-5 (1996).

Dowsett M, Bundred NJ, Decensi A et al. Cancer Epidemiol Biomarkers Prev. 10:961-6 (2001).

Seeman E. J Bone Miner Metab. 19:65-75 (2001).

R0245 Raltitrexed 10 mgC21H22N4O6S FW 458.49 [112887-68-0] 25 mgAn antimetabolite drug used in cancer chemotherapy which is an inhibitor 100 mgof thymidylate synthase.Liao, Zhi-Yong, Cancer Research (2005), 65(11), 4844-4851.

R0248 Ramatroban 10 mgC21H21FN2O4S FW 416.47 [116649-85-5] 25 mgA thromboxane receptor antagonist, a CRTH2 antagonist. It is indicated for the 100 mgtreatment of coronary artery disease. It has also been used for the treatment of asthma.

Sugimoto H, Shichijo M, Iino T, et al. (April 2003). J. Pharmacol. Exp. Ther. 305 (1): 347–52.

R0348 Ramelteon 10 mgC16H21NO2 FW 259.34 [196597-26-9] 25 mgIs the first in a new class of sleep agents that selectively binds to the MT1 and MT2 100 mgreceptors in the suprachiasmatic nucleus (SCN), instead of binding to GABA A receptors.

Owen RT. Drugs Today 42:255-263 (2006).

R0249 Ramipril (See page 25 for more information) 500 mgC23H32N2O5 FW 416.51 [87333-19-5] 1 gAn angiotensin-converting enzyme (ACE) inhibitor. 5 gRamipril is a prodrug of the active metabolite ramiprilat which is formed upon absorption.

Warner GT, Perry CM. Am J Cardiovasc Drugs. 3:113-6 (2003).

N O

S

O

HO

OH

HCl

NH

N

CH3 H

HO

OOH3C HOOC

O

OCl

OH

HO

OOCH3

H

N

OHO

NH

S

O O

F

N

HN

O

NS

O

NH

CO2H

HO2C

HN

O

O

O

HN

O

O

S CH3

O

HO

HN

OH

OH

CH3

HCl


R0349 Ramosetron 10 mgC17H17N3O FW 279.34 [132036-88-5] 25 mgIs a serotonin 5HT3 receptor antagonist for the treatment of nausea and vomiting 100 mg in post-operative situationsLee, H.-J. European Journal of Anaesthesiology (2008), 25(9), 756-762. Matsueda, Kei. Scandinavian Journal of Gastroenterology (2008), 43(10), 1202-1211.

R0250 Ranatensin 1 mgC61H85N16O13S FW 1281.5 [29451-71-6] 2 mgA frog skin peptide that interferes with nociception by action on the D2 receptor. 5 mgZhu HZ, Ji XQ, Wu SX et al. Chung Kuo Yao Li Hseuh Pao. 12(4):291-293 (1991).

R0251 Ranatensin R 1 mgC90H134N30O24S FW 2052.3 [70572-93-9] 2 mg

5 mg

R0253 Ranitidine hydrochloride 1 gC13H23ClN4O3S FW 350.86 [66357-59-3] 5 gA histamine H2-receptor antagonist used in the treatment of gastrointestinal

lesions due to excessive gastric acid secretion.

Grant SM, Langtry HD, Brogden RN. Drugs. 37:801-70 (1989).

Boyd EJ, Wilson JA, Wormsley KG. J Clin Gastroenterol. 5 Suppl 1:133-41 (1983).

R0154 Ranolazine Dihydrochloride 100 mgC24H33N3O4

.2HCl FW 500.47 [95635-56-6] 500 mgA novel metabolic modulator and membrane stabilizer. It is an antiischaemic and 1 gantianginal agent. Shifts myocardial energy metabolism away from free fatty acids

and toward glucose as the substrate for production of adenosine triphosphate.Schofielf RS, Hill JA. Expert Opin Investig Drugs. 11:117-23 (2002).

McCormack JG, Barr RL, Wolff AA et al. Circulation. 93:135-42 (1996).

Lodge JP, Lam FT, Perry SL et al. Transplantation. 50:755-9 (1990).

R0161 Rapamycin 1 mgC51H79NO13 FW 914.17 [53123-88-9] 10 mgAn antifungal antibiotic that has immunosuppressive activity. It blocks 25 mgcytokine-mediated signal transduction pathways.

Singh K, Sun S. Vezina C. J Antibiot (Tokyo). 32:630-45 (1979).

Sehgal SN. Ther Drug Monit. 17:660-5 (1995).

R0272 Rasagiline 25 mgC12H13N FW 171.24 [136236-51-6] 100 mgRasagiline is an irreversible inhibitor of monoamine oxidase used as a 250 mg monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases.

It is selective for MAO type B over type A by a factor of fourteen.

Zhu, W. Journal of Neurochemistry (2008), 105(5), 1970-1978.

R1806 Rebamipide 1 gC19H15ClN2O4 FW 370.79 [90098-04-7] 5 gAn antiulcer agent that enhances mucosal resistance. It increases endogenous 25 g prostaglandin in gastric mucosa, and also scavenges oxygen-derived free radicals

and inhibits their production.

Otsubo K. Morita S. Uchida M et al. Chem Pharm Bull. 39:2906-9 (1991).

Iinuma S. Naito Y. Yoshikawa T et al. Dig Dis Sci. 43:35S-39S (1998).

O

S

NH

NH

NO2

N

.HCl

N

O

O

O

H

O

OH

OCH3

H

CH3

H

O

H3C

H3C

OH

OH3CO

CH3

CH3

CH3

H3CO

H

H3COH

O

Ser-Asn-Thr-Ala-Leu-Arg-Arg-

Tyr-Asn-Gln-Trp-Ala-Thr-Gly-

His-Phe-Met-NH2

pGlu-Val-Pro-Gln-Trp-Ala-Val-

Gly-His-Phe-Met-NH2

NH

NH

Cl

O

COOH

O

OCH3

O N

N

OH3C

HN

CH3

OH

2HCl

N

H3C

O

N

NH

HN


R2711 Recombinant HCV-Core antigens 100 µg(See page 30 for more information) 1 mg

R2712 Recombinant HCV-NS3 antigens 100 µg

(See page 30 for more information) 1 mg

R2713 Recombinant HCV-NS4 antigens 100 µg(See page 30 for more information) 1 mg

R2714 Recombinant HCV-NS5 antigens 100 µg(See page 30 for more information) 1 mg

R2811 Recombinant HIV-1 gp-41 100 µg(See page 30 for more information) 1 mg

R2812 Recombinant HIV-1 gp-120 100 µg(See page 30 for more information) 1 mg

R2815 Recombinant HIV-1"O"group consensus 100 µg


R2816 Recombinant HIV-2 gp36 100 µg


R2710 Recombinant Multi-epitope Chimeric 100 µg

HCV antigen 1 mg(Core, NS3, NS4, NS5)

(See page 30 for more information)

R2810 Recombinant Multi-epitope Chimeric 100 µg

HIV antigen-1 1 mg(gp41, "O"IDR, gp36)

(See page 30 for more information)

R3010 Recombinant Tp-chimeric protein 100 µg

(TpN15, TpN17, TpN44.5, TpN47) 1 mg(See page 30 for more information)

R3011 Recombinant TpN 15 protein 100 µg




R3013 Recombinant TpN 44.50 protein 100 µg





R1752 Renin Inhibitor Peptide 5 mgC52H73N13O9 FW 1024.24 10 mg

25 mg

R1860 Repaglinide 100 mgC27H36N2O4 FW 452.59 [135062-02-1] 250 mgPotent short-acting insulin secretagogue that acts by closing ATP-sensitive potassium 1 g(KATP) channels in the plasma membrane of the pancreatic beta cell. It represents

a new class of insulin secretagogues, structurally unrelated to sulphonylureas, which

were developed for the treatment of type 2 diabetes.

Hansen, A.M., et al., Diabetes 51, 2789-2795, (2002)

R1774 Resiniferatoxin 1 mgC37H40O9 FW 628.73 [57444-62-9] 5 mgNatrual product isolated from Euphorbia poisonii. RTX is an irritant to skin 10 mg and mucous membranes, but not a tumor promoter. It is an extremely potent

capsaicin analog that stimulates, with subsequent desensitization of specific subpopulations,

sensory receptors.

Hergenhahn M, Kusumoto S, Hecker EJ. Cancer Res. Clin.Oncol. 108:98-109 (1984).

Szallasi A, Blumber PM, Life Sci. 47:1399-1408 (1990).

Dray A, Biochem. Pharm. 44:611-615 (1992).

R1775 Resiniferonol-9,13,14-orthophenyl acetate (ROPA) 1 mgC28H32O6 FW 464.56 [57852-42-3] 5 mgROPA is a hydrolysis product of resiniferatoxin. 10 mgROPA retains its strong skin irritant property.

It is used to reconstitute either resiniferatoxin or tinyatoxin.Jang M, Cai L, Udeani GO et al. Science, 275:218-220 (1997).

Carbo N, Costelli P, Baccino FM, Lopez-Soriano FJ. Biochem Ciophys Res Commun. 254:739-43 (1999).

Gautam SC, Xu YX, Dumaguin M et al. Bone Marrow Transplant. 25:639-45 (2000).

R1776 Resveratrol (See page 13 for more information) 100 mgC14H12O3 FW 228.24 [501-36-0] 500 mgAn antioxidant found in grapes, shown to have significant chemopreventive activity.

Jang M, Cai L, Udeani GO et al. Science. 275:218-220 (1997).

Carbo N, Costelli P, Baccino FM, Lopez-Soriano FJ. Biochem Ciophys Res Commun. 254:739-43 (1999).

Gautam SC, Xu YX, Dumaguin M et al. Bone Marrow Transplant. 25:639-45 (2000).

R1977 Retigabine 10 mgC16H18FN3O2 FW 303.33 [150812-12-7] 25 mgUnder development as a novel anticonvulsant agent. Its acts as a neuronal 100 mgKCNQ/Kv7 potassium channel opener, a mechanism of action completely different

from those of presently marketed antiepileptics.

Rundfeldt C. Eur. J. Pharmacol. 336: 243–249 (1997).

Main MJ, Cryan JE, Dupere JR, et al. Mol. Pharmacol. 58:253–262 (2000).

R1978 Retigabine Dihydrochloride 10 mgC16H18FN3O2

.2H2O FW 376.25 [150812-13-8] 25 mgA KCNQ/Kv7 potassium channel activator. It may also act as a GABA enhancer. 100 mgCzuczwar, P., et al. Pharmacol Rep. 62: 211-219 (2010).

HO

OH

OH

H-His-Pro-Phe-His-Leu-D-Leu-

Val-Tyr-NH2

HN

H2N NH

O

O

F

HN

H2N

O

ONH

F

2HCl

O

CO2HO

NH

N

OO

HO

O

C

H2C

H

O

H

CH2OH

OO

HO

OC

H2C

O

CH2

CH2OCO

OH

OCH3

H H


R1777 9-cis-Retinoic acid 1 mgC20H28O2 FW 300.44 m.p. 189-1900C [5300-03-8] 5 mgA vitamin A analog that inhibits cell proliferation and induces cell differentiation. 25 mgKelloff GJ, Crowell JA, Hawk ET et al. J. Cell. Biochem Suppl. 26:54-71 (1996).

Zheng Y, Kramer PM, Olson G et al. Carcinogenesis. 18:2119-2125 (1997).

R1779 13-cis-Retinoic acid 100 mgC20H28O2 FW 300.44 m.p. 174-1750C [4759-48-2] 250 mgA vitamin A analog that inhibits cell proliferation and induces cell differentiation. 500 mgKelloff GJ, Crowell JA, Hawk ET et al. J. Cell. Biochem Suppl. 26:54-71 (1996).

R1780 trans-Retinoic acid 500 mgC20H28O2 FW 300.44 m.p. 180-1810C [302-79-4] 1 gThe active metabolite of vitamin A. A potential chemopreventive against skin, 5 gcolon, and mammary tumors.M Leid, Kastner P, Chambon P. Trends Biochem. Sci. 17:427-33 (1992).

Athar M, Agarwal R, Wang ZY et al. Carcinogenesis. 12:2325-9 (1991).

Stopera SA, Bird RP. Int. J. Cancer. 53:798-803 (1993).

Toma S, Isnardi L, Raffo P et al. Int. J. Cancer. 70:619-27 (1997).

R1876 all-trans-Retinol 100 mgVitamin A 250 mgC20H30O FW 286.45 m.p. 63-640C [11103-57-4] 500 mgInhibits cell proliferation and induces cell differentiation.

Kelloff GJ, Boone CW, Crowell JA et al. Cancer Epidemiol. Biomarkers Prev. 3:85-98 (1994).

R1878 Retinyl acetate 5 gC22H32O2 FW 328.49 m.p. 57-580C [127-47-9] 25 gA vitamin A analog that inhibits cell proliferation and induces cell differentiation. 100 gA chemopreventive against rat mammary tumors.Grubbs CJ, Eto I, Juliana MM et al. Anticancer Res. 10:661-666 (1990).

R1879 Retinyl palmitate 25 gC36H60O2 FW 524.86 [79-81-2] 100 gA vitamin A analog that inhibits cell proliferation and induces

cell differentiation. Effective in lung cancer chemoprevention.

Pastorino U, Soresi E, Clerici, M et al. Acta Oncol. 27:773-782 (1988).

R1985 Reveromycin A 100 µgC36H52O11 FW 660.79 [134615-37-5] 5 x 10 µgAn inhibitor of eukaryotic cell growth. Shown to have a strong antitumor effect against

human ovarian carcinoma BG-1.

Takahashi H, Yamashita Y, Takaoka H. Oncol Res. 9:7-11 (1997).

Osada H. Curr Med Chem. 10:727-732, (2003).

R2112 RFDS 5 mgC22H33N7O8 FW 523.5

R2353 R-F-NH2 5 mgC15H24N6O2 FW 320.4 [34388-59-5] 10 mg

25 mg

CH2OH

O

CCH2OCH3

O

CCH2O (CH2)14CH3

CO2H

O

O

O

OH

CH3H3C

HO

OH

O

O

OH3C

CH3

OH

O

H3C

Arg-Phe-Asp-Ser

H-Arg-Phe-NH2

OHO

CO2H


R2369 RFRP-1, human 0.5 mgC67H101N19O14S FW 1428.73 1 mg

2.5 mg

R2512 RGD 5 mgC12H22N6O6 FW 346.3 [99896-85-2] 10 mgAntineoplastic agent. 25 mg

R2510 RGD-4C 1 mgC42H60N14O16S4 FW 1145.29 2 mg

5 mg

R2511 R-G-D-C 5 mgC15H26N7O7S1 FW 448.48 10 mg

25 mg

R2513 RGDS 5 mgC15H27N7O8 FW 433.4 [91037-65-9]Platelet aggregation inhibitor.

R2514 RGDV 5 mgC17H31N7O7 FW 445.5 [93674-99-8] 10 mgThe 4-residue sequence found at the cell-adhesive region of the peptide vitronectin. 25 mgLin HB, Garcia-Echeverria C, Asakura S et al. Biomaterials. 13:905-914 (1992).

R2516 R-G-E-S 0.5 mgC16H29N7O8 FW 447.45 [93674-97-6] 1 mgA tetrapeptide structurally similar to RGDS. RGDS is a synthetic peptide that 2.5 mg represents the fibroblast binding site of fibronectin. RGES is often used in fibro

blast binding experiments.

Pasula R, Wisniowski P, Martin WJ 2nd. Infect Immun. 70:1287-92 (2002).

R2599 R-G-Y-S-L-G 1 mgC28H45N9O9 FW 651.73 [110590-63-1] 2 mgA synthetic peptide that represents the active site of a protein kinase. 5 mgPattanaik A, Gowda DC, Urry DW. Biochem Biophys Res Commun. 178:539-45 (1991).

R2917 Rhein 100 mgC15H8O6 FW 284.22 [478-43-3] 500 mgInduces apoptosis in cancer cell lines and inhibits transforming growth 1 gfactor beta1 induced plasminogen activator inhibitor-1 in endothelial cells.

Zhu J, Liu Z, Huang H, Chen Z, Li L. Chin Med J (Engl).116:354-9 (2003).

Huang YH, Zhen YS. Yao Xue Xue Bao. 36:334-8 (2001).

R3205 Ribavirin 50 mgC8H12N4O5 FW 244.21 [36791-04-5] 100 mgSynthetic broad-spectrum antiviral nucleoside found to have antitumor activity 500 mg on L1210 leukemia in mice. It regulates signal transduction in human ovarian cancer cells.

Li W, Shen F, Weber G. Oncol Res. 11:243-7 (1999).

Jolley WB, Chu WT, Salter JM. Ann N Y Acad Sci. 284:585-90 (1977).

O

OH OH

CH3HO

N

N

N

CONH2

H H

H H

Arg-Gly-Asp-Val

H-Arg-Gly-Glu-Ser-OH

Asp-Cys-Phe-Cys-Gly-OH

(Cys2-Cys10 , Cys4-Cys8)

H-Met-Pro-His-Ser-Phe-Ala-

Asn-Leu-Pro-Leu-Arg-Phe-NH2

Arg-Gly-Asp

H-Arg-Gly-Asp-Cys-OH

Arg-Gly-Asp-Ser

H-Arg-Gly-Tyr-Ser-Leu-Gly-OH

O

O

OHOH

COOH


R3206 Riboflavin 25 gC17H20N4O6 FW 376.36 [83-88-5] 100 gRiboflavin deficiency causes formation of single strand breaks in nuclear DNA,

increases carcinogen-DNA binding and decreases hepatic glutathione content. All of

this can be reversed by riboflavin supplementation.

Webster RP, Gawde MD, Bhattacharya RK. Cancer Lett. 98:129-35 (1996).

Pangrekar J, Krishnaswamy K, Jagadeesan V. Food Chem Toxicol. 31:745-50 (1993).

Chiao CH, Chung Hua Chung Liu Tsa Chih.11:92-4 (1989).

R3310 Ricobendazole 10 gAlbendazole sulfoxide 25 gC12H15N3O3S FW 281.33 [54029-12-8] 100 gActive metabolite of albendazole, an anthelmintic.Castillo JA, Palomo-Canales J, Garcia JJ et al. Drug Dev Ind Pharm. 25:1241-8 (1999).

R3312 Ridaifen A Dihydrochloride 25 mgC30H40Cl2N2O2 FW 531.56 100 mgRidaifen A showed cytotoxicity on HL-60 human promyelocytic leukemia cells 250 mgRidaifen A also induced apoptosis in Jurkat cells.

Shiina, Isamu; Ikekita, Masahiko; Matsunaga, Taichi; Nagahara, Norimune. Jpn. Kokai Tokkyo Koho (2006).

R3220 Rifampin 1 gRifampicin 5 gC43H58N4O12 FW 822.94 [13292-46-1] 25 gAn antibacterial from 3-formyl rifamycin SV.

Maggi et al. Chemotherapia. 11:285 (1966).

R3221 Rifamycin SV-3 formyl 1 gC38H47NO13 FW 725.78 [13292-22-3] 5 gA derivative of rifamycins found to interact with biological membranes. It causes 10 g a change in permeability to K+ and H+ in the mitochondrial membrane.

Inouye B, Uchinomi Y, Wachi T, Utsumi K. J Antibiot (Tokyo). 30:494-9 (1977).

R3222 Rifamycin SV-Sodium 1 gC37H46NNaO12 FW 719.75 [14897-39-3] 5 gAn antimicrobial agent, inhibits DNA polymerase.

Furesz S, Arioli V, Pallanza R. Antimicrob Agents Chemother. 5:770-7 (1965).

Frolova LY, Meldrays YA, Kochkina LL et al. Nucleic Acids Res. 4:523-38 (1977).

R3321 Rifaximin 500 mgC43H51N3O11 FW 785.88 [80621-81-4] 1 gA rifamycin derivative. It is a non-absorbable broad-spectrum antibiotic that 5 g possesses in vitro activity against a wide range of bacteria. It acts by inhibiting

bacterial ribonucleic (RNA) synthesis.

Prasad ES, Wenman WM. Diagn Microbiol Infect Dis. 16:135-6 (1993).

Gillis JC, Brogden RN. Drugs. 49:467-84 (1995).

R3224 Rigin 5 mgC18H32N8O6 FW 456.51 [77727-17-4] 10 mgTuftsin-like tetrapeptide that stimulates phagocytosis activity. Rigin 25 mgdemonstrates high stress-protective activity in neuroendocrine and immune systems

in rats. It stimulates release of interleukin-1 and tumor necrosis factor from mouse peritoneal

macrophages and from human monocytes.

Rocchi R, Biondi L, Filira F, Tzehoval E, Dagan S, Fridkin M.Int J Pept Protein Res. 37:161-6 (1991).

Klusha VE, Mutsenietse RK, Svirskis ShV, Zalitis GM, Liepa IR. Biull Eksp Biol Med. 104:186-7 (1987).

N

NO

NH

OHO

CH3

O

CH3

OH

CH3

HO

OH

CH3

CH3O

H3C

O

O

H3CO

CH3

CH3

CH3

N

HN

H3CH2CH2CS

NHCOCH3

O

O

ONa

O

O

O

OH O

NH

OHOH

O

O

O

HO

OH

O

O

O

OH O

NH

OHOH

O

O

O

HO

CH

O

N

N

NOH

O

O

O

OH O

NH

OHOH

O

O

O

HO

N

N

NH

NH3C

H3C

O

O

H2C CH

CH CH2OH

OH OH

CH

OH

H-Gly-Gln-Pro-Arg-OH

H3C

O

O

N

CH3

CH3

N

CH3

CH3

2HCl


R3249 Rimantadine Hydrochloride 25 mg

C12H21N.HCl FW 215.76 [1501-84-4] 50 mgUsed for influenza A treatment and prevention.

Tominack RL, Hayden FG. Infect Dis Clin North Am. 1:459-78 (1987).

R3347 Riluzole 25 mgRilutek 250 mgC8H5F3N2OS FW 234.19 [1744-22-5] 500 mgHas anticonvulsant activity and inhibits glutamate release. Has been used to treatamyotrophic lateral sclerosis.Mantz, et al Anesthesiology 76:844 (1992).

van Kan HJ, Groeneveld GJ, Kalmijn S, Spieksma M, van den Berg LH, Guchelaar HJ Br. J. Clin. Pharmacol. 59:310-3 (2005).

R3373 Risedronate sodium hydrate 100 mgC7H10NO7P2Na 2.5H2O FW 350.13 [115436-72-1]

A pyridinyl biphosphonate. It inhibits osteoclast-mediated bone resorption.

Boiser S, Ferreras M, Peyruchaud O, Magnetto S. Cancer Res. 60:2949-54 (2000).

Goa KL, Balfour JA. Drugs Aging. 13:83-91 (1998).

R3374 Risedronic acid 100 mg

C7H11NO7P2 FW 283.11 [105462-24-6]A biophosphonate that displays potent inhibition of bone resorption. Shown to prevent

bone metastases in rats.

Muhlbauer RC, Bauss F, Schenk R. J Bone Miner Res. 6:1003-1011 (1994).

R3475 Risperidone 100 mg

C23H27FN4O2 FW 410.48 [106266-06-2] 250 mg

Is an atypical anti-psychotic used for the treatment of schizophrenic and bipolar 1 gdisorders. A typical neuroleptic, it is a strong dopamine antagonist with a high

affinity for D2 dopaminergic receptors.

Vehof, J. Journal of Clinical Psychopharmacology (2008), 28(6), 625-630.

R3477 Ritodrine 250 mg

Ritodrina, Ritodrinium 1 gC17H21NO3

.HCl FW 323.81 [23239-51-2] 5 gAdrenergic b2-agonist that relaxes uterine muscle. It is used to stop premature labor.Bassett JM, Symonds ME Am. J. Physiol. 275:R112-R119 (1998).

R3577 Ritonavir 100 mgC37H48N6O5S2 FW 720.95 [155213-67-5] 250 mgA novel protease inhibitor, for human immunodeficiency virus (HIV). 1 gSanjay RC, Bauer J, Deming K, et al. Org. Proc. Res. Dev. 4:413-417 (2000).

R3584 Rivaroxaban 1 mgC19H18ClN3O5S FW 435.88 [366789-02-8] 5 mgAn oral anticoagulant 25 mgRoehrig S, Straub A, Pohlmann J, et al. J. Med. Chem. 48:5900-5908 (2005).

CH3

NH2

HCl

OH

CH3

HN

OHHO HCl

NO

N

F

N

N

O

CH3

S

N

NH2

F3CO

N

HO PO3H2

PO3H2

N

HO PO3H

PO3H2Na

2.5H2O

NH

OH

HN

O

O

N

S

O

NH

O

NN

S

O

N

N

OO

O

HN

O

S

Cl


R3586 Rivastigmine Hydrogen Tartrate 100 mg

C18H28N2O8 FW 400.42 [129101-54-8] 250 mg

is a parasympathomimetic or cholinergic agent for the treatment of mild to 1 g moderate dementia of the Alzheimer’s type and Parkinson's disease.

Winblad, Bengt, Expert Opinion on Drug Delivery (2008), 5(12), 1377-1386

R5611 Rocuronium Bromide 10 mg

C32H35BrN2O4 FW 609.68 [119302-91-9] 25 mg

an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used 100 mg in modern anesthesia to facilitate endotraceal intubation.Auer, U. Veterinary Journal (2007), 173(2), 422-427.

R5722 Rofecoxib (See page 17 for more information) 100 mgC17H14O4S FW 314.36 [162011-90-7] 250 mgA cyclooxygenase-2 inhibitor (COX-2) that is used as an anti-inflammatory 1 gcompound.

Catella-Lawson, F. et al. J. Pharmacol. Exp. Ther. 289: 735 (1999).

R5661 Ropinirole Hydrochloride 25 mg

C16H24N2O.HCl FW 296.84 [91374-20-8] 100 mgA dopamine receptor agonist commonly used to treat Parkinson disease and 500 mg restless legs sydrome.

Gallagher G Jr, Lavanchy PG, Webster CA et al. J Med Chem. 28:1533-1536 (1985).

Anonymous, Health News. 10:2 (2004).

R5772 Rosiglitazone Maleate (See page 18 for more info) 500 mgC18H19N3O3S. C4H4O4 FW 473.51 [155141-29-0] 1 gA thiazolidinedione antidiabetic agent. It is a potent insulin sensitizing agent and a 5 gperoxisome proliferator-activated receptor-γ (PPAR-γ ) agonist. It was found to have hepatoxicity.

McMorran M. Vu D. CMAJ. 165:82-3, 86-7 (2001).

Parks DJ. Tomkinson NC. Villeneuve MS. et al. Bioorg Med Chem Lett. 8:3657-8 (1998).

Knock GA. Mishra SK. Aaronson PI. Eur J Pharmacol. 368:103-9 (1999).

R5773 Rosiglitazone 500 mgC18H19N3O3S FW 357.43 [122320-73-4] 1 gRosiglitazone stimulates AMP-activated protein kinase. 5 gFryer, LG., Parbu-Patel, A., Carling, D. J Biol. Chem. 277:25226-25232 (2002).

R5874 Rosmarinic Acid 10 mgC18H16O8 FW 360.31 [20283-92-5] 25 mgNatural product isolated from rosemary, sweet basal and perilla. It has 100 mg anti-inflammatory activity and inhibits the proliferation of murine mesangial cells.

Makino T, Ono T, Muso E et al. Nephrol Dial Transplant. 15:1140-5 (2000).

Englberger W, Hadding U, Etschenberg E et al. Int J Immunopharmacol. 10:729-37 (1988).

R5974 Rosuvastatin Calcium 25 mg2(C22H28FN3O6S) Ca2+ FW 1001.14 [147098-20-2] 100 mgRosuvastatin is a synthetic enantiomer that has demonstrated reduction of low-density 250 mglipoprotein cholesterol (LDL-C).

Davidson MH. Expert Opin Investig Drugs. 2002 Jan;11(1):125-41.

O

O

HO

HO

OH

OH

COOHH

HN

O

N

H3C

H3C

HCl

NN

HO

CH3

CH3O

H3C

O

O

H2C

Br

O

O

N

CH3

CH3

CH3

NCH3H3C

HO

O

OH

O

OH

OH

N

N NS

HO

HO

O

O

O

O

F

2

Ca2+

N

NO O N

H

S

O

CH3

.C4H4O4

N

NO O N

H

S

O

CH3

O

O

SH3C

OO


R5878 Rotenone 1 gC23H22O6 FW 394.41 [83-79-4] 5 gRotenone is an odorless chemical that is used as a broad-spectrum insecticide, 25 gpiscicide, and pesticide. It occurs naturally in the roots and stems of several plants

such as the jicama vine plant.Tanner CM, Kamel F, Ross GW, et al. Environ. Health Perspect. 119:866-872 (2011).

R5894 Roxatidine Acetate Hydrochloride 100 mg

C19H28N2O4.HCl FW 384.90 [93793-83-0] 500 mg

A histamine H2-receptor antagonist used in ulcer treatment. 1 gFound to inhibit platelet function in vitro.

Brandstatter G, Marks IN, Lanza F et al. Clin Ther. 17:467-478 (1995).

Nakamura K, Kariyazono H, Shinkawa, T et al. Human Exptal Tox. 18: 487-492 (1999).

R5992 Roxithromycin 1 gC41H76N2O15 FW 837.05 [80214-83-1] 5 gAn antibiotic with a wide antibacterial spectrum against oral pathogens and an 10 gimmunomodulatory effect. It has also been shown to increase neutrophil apoptosis,

reduce tumor size of B16BL6 melanoma, and inhibit pulmonary metastasis of B16BL6 cells.

Yatsunami J, Tsuruta N, Fukuno Y et al. Clin Exp Metastasis. 17:119-24 (1999).

Oyama T, Sakuta T, Matsushita K et al. J Periodontal. 71:1546-53 (2000).

R6871 RR-SRC 5 mgC64H106N22O21 FW 1519.7 10 mgA tyrosine kinase-specific substrate often used in experiments to determine 25 mgTyr kinase activity.

Shen SS, Kinsey WH, Lee SJ. Dev Growth Differ. 41: 345-55 (1999).

R6873 R-S-R 1 mgC15H31N9O5 FW 417.5 2 mg

5 mg

R8206 Rubescensin A 25 mgOridonin 100 mgC20H28O6 FW 364.43 [28957-04-2] 500 mgA diterpene isolated from the leaves of Rabdosia rubescens Hora. It appears to have

antitumor activity in cell culture studies.

Li XT, Lin C, Li PY. Chinese J Oncology. 8:184-186 (1986).

Fuji K, Node M, Sai M et al. Chem Pharmaceut Bull. 37:1472-1476 (1989).

R8207 β-Rubromycin 1 mgC27H20O12 FW 536.44 [27267-70-5] 5 mgA quinone antibiotic agent. Found to inhibit reverse transcrisptase from HIV-1 to a greater

degree than it inhibits cellular DNA polymerase alpha.

Goldman ME, Salituro GS, Bowen JA et al. Mol Pharmacol. 38:20-25 (1990).

R8122 Rufloxacin Hydrochloride 25 mgC17H18FN3O3S.HCl FW 399.87 [106017-08-7] 100 mgA fluoroquinolone antibacterial that shows photosensitizing properties toward 500 mgbiological substrates. It inhibits B-cell differentiation in human mononuclear cells.

Gollapudi S, Perumal V, Thadepalli H, J Antimicrob Chemother. 29:669-76 (1992).

Condorelli G. De Guidi G, Giuffrida S et al. Photochem Photobiol. 70:280-6 (1999).

N

COOH

O

F

N

N

H3C

S

HCl

OH

OH

H

H

OH

O

OH

O

OCH3

H3CO

OH O

O

O O

O

O

COOCH3

HO

H3C O

HN O

N

O

O

.HCl

H-Arg-Ser-Arg-OH

H-Arg-Arg-Leu-Ile-Glu-Asp-

Ala-Glu-Tyr-Ala-Ala-Arg-Gly-

OH

O

CH3O

CH3

H3COH

OH

H3C

N

CH3

H3C

CH3

O

O OOCH3

O

OH3C

OHCH3

OCH3O

HOCH3

N CH3

H3COH

O

O

O

H

H

O

O

O


R8178 Rutaecarpine 10 mgRutecarpine 25 mgC18H13N3O FW 287.32 [84-26-4] 100 mgAn alkaloid isolated from the chinese herb Evodia rutaecarpa. It has vasorelaxing effect and

inhibits platelet aggregation and COX-2. It is a selective inhibitor of cytochrome P450 1A.

Chiou WF, Chou CJ, Liao JF et al. Europ J Pharm. 257:59-66 (1994).

Sheu JR, Hung WC, Lee YM, Yen MH. Europ J Pharm. 318:469-475 (1996).

Moon TC, Murakami M, Kudo I et al. Inflam Res. 48:621-625 (1999).

Ueng, YF., Jan, WC., Lin, LC. et al Drug Metab. Disp. 30:349-353 (2002).

R8179 Rutaecarpine (Synthetic) 100 mgC18H13N3O FW 287.32 [84-26-4] 250 mgSynthetic versioin of Rutaecarpine. 1 g

R8076 Rutin Hydrate 50 gC27H30O16 FW 610.52 [153-18-4] 100 gA glycoside of quercetin. Inhibits the initiation and promotion 500 gstages of carcinogenesis, and enhances detoxification. An effective

inhibitor of carcinogen-induced aberrant crypt foci in the rat colon.

Elangovan V, Sekar N, Govindasamy S. Cancer Lett. 87:107-113 (1994).

Wargovich MJ, Chen CD, Jimenez A et al. Cancer Epidimiol. Biomarkers Prev. 5:355-360 (1996).

S0006 S6-1 1 mgC39H75N17O11 FW 958.14 [93674-74-9] 2 mgA sythetic octapeptide that represents the phosphorylated region of the S6 protein. 5 mgHecht LB, Straus DS. Endocrinology. 119: 470-80 (1986).

S0132 Saikosaponin A 1 mgC42H68O13 FW 780.98 [20874-52-6] m.p. 225-2320C 5 mgThe saikosaponins have potent anti-inflammatory activity on mouse ear edema induced by the tumor promoter, phorbol myristate acetate. In cell culture studies, they have been found to induce differentiation without growth inhibition and apoptosis in B16 melanoma cells. Zong Z, Fujikawa-Yamamoto K, Ota T et al. Cell Struct Funct. 23:265-272 (1998).

Bermejo BP, Abad Martinez MJ, Silvan Sen AM et al. Life Sci. 63:1147-1156 (1998).

Zong Z, Fujikawa-Yamamoto K, Tanino M et al. Biochem Biophys Res Commun. 219:480-485 (1996).

Ohtsuka M, Fukuda K, Yano H, Kohiro M. Jpn J Cancer Res. 86:1131-1135 (1995).

Qian L, Murakami T, Kimura Y et al. Pathol Int. 45:207-214 (1995).

S0032 Saikosaponin B1 1 mgC42H68O13 FW 780.98 [58558-08-0] 5 mgSaidosaponin B1 induces PGE2 release in C6 rat glioma cells. In cultured fibroblasts saikosaponin B1 suppresses the blockage of signal transduction after binding of EGF resulting in growth stimulation.Kyo R, Nakahata N, Kodama Y et al. Biol Pharm Bull. 22:1385-7 (1999).

Nishiyama T, Horii I, Nakayama Y et al. Matrix. 10:412-9 (1990).

S0033 Saikosaponin B2 1 mgC42H68O13 FW 780.98 5 mgSaikosaponin B2 inhibits the proliferation of B16 melanoma cells in culture by induction

of apoptosis. The inhibition is a result of G1 phase accumulation.Zong Z, Fujikawa-Yamamoto K, Tanino M, et al. Biochem Biophys Res Commun. 219:480-5 (1996).

S0133 Saikosaponin C 1 mgC48H78O17 FW 927.12 m.p. 202-10oC [58558-08-0] 5 mgSaikosaponin C was found to have inhibiting activity in hepatitis B virus DNA replicaiton.Chiang LC, Ng LT, Liu LT et al. Planta Med. 69:705-9 (2003).

N

N

NH

O

H-Arg-Arg-Leu-Ser-Ser-Leu-

Arg-Ala-OH

O

O

O

HO

OH CH3

HOH2C

HO

HO

HO

O

H3C

CH3 CH3

OH

CH2OH

H3C

CH2OH

CH3

CH3

H O

OH H

H

OHH

OH

CH2OH

H

OH O

H H

H

OHH

O

CH3

H

O

H3C

CH3 CH3

OH

H

CH3

CH3

H

CH2OH

H3C

O

O

O

O

HO

OH CH3

HOH2C

HO

HO

HO

O

H3C

CH3 CH3

OH

CH2OH

H3C

CH2OH

CH3

CH3

OH O

H H

H

OHOH

H

H

CH3

H O

O H

H

OHH

OH

CH2

H

O

H3C

CH3 CH3

OH

H

CH3

CH3

H

CH3

H3C

O

H O

OH H

H

OHH

OH

CH2OH

H

O

O

OOH

l-ORutinosy

OH

OH

OH

N

N

NH

O


S0134 Saikosaponin D 1 mgC42H68O13 FW 780.98 [20874-52-6] m.p. 212-8oC 5 mgSaikosaponin D was found to stimulate corticotropin-releasing factor (CRF) gene expression and

CRF release. It also increases adrenocorticotropin release.

Dobashi I, Tozawa F, Horiba N et al. Neurosci Lett. 197:235-238 (1995).

S0044 Salbutamol free base 25 mgAlbuterol 50 mgC13H21NO3 FW 239.31 [18559-94-9] 100 mgA beta-adrenoceptor agonist. 500 mgChurch MK, Hiroi J. Br J Pharmacol. 90:421-9 (1987).

S0045 Salbutamol sulfate 25 mgAlbuterol sulfate 50 mg(C13H21NO3)2

.H2SO4 FW 576.7 [51022-70-9] 100 mgA beta-adrenoceptor agonist. 500 mgChurch MK, Hiroi J. Br J Pharmacol. 90:421-9 (1987).

S0048 Salicin 5 gC13H18O7 FW 286.28 [138-52-3] 25 gAn analgesic and antipyretic. Reported to have antileukemic activity. Smith ID, Temple DM, Shearman RP. Prostaglandins. 10:41-57 (1975).

El-Shemy HA, Aboul-Enein AM, Aboul-Enein MI et al. J Biochem Mol Biol. 36: 387-389 (2003).

S0049 Salmon Calcitonin Acetate Please inquireC145H240N44O48S2 FW 3431.9 [47931-85-1]Salmon calcitonin acetate positively influences bone mass density due to its inhibiting effect on osteoclast activity. For the treatment of osteoporosis, paget’s disease, hypercalcemia, reflex sympathetic dystrophy (algodistrophy or Sudeck’s disease).

Kopaliani M. Georgian Med News. 121: 38-42 (2005).

S0244 Salsalate 25 g

C14H10O5 FW 2589.23 [552-94-3] 100 gSalsalate is a non-steroidal anti-inflammatory drug (NSAID). Salsalate is in a class

of drugs called salicylates. Salsalate may work by inhibiting the production of and release of prostaglandins.

Gupta, S. K. AIDS (2008), 22(5), 653-655.

S0046 Salsolidine 25 mgC12H17NO2 FW 207.27 [493-48-1] 100 mgA tetrahydroisoquinolone that is a steroselective competitive inhibitor of the enzyme monoamine oxidase.

It is also a competitive inhibitor of catechol-O-methyltransferase.Bembenek ME, Abell CW, Chrisey LA et al. J Med Chem. 33:147-52 (1990).

Dostert P, Strolin Benedetti M, Dordain G. J Neural Transm. 74:61-74 (1988).

Sanft K, Thomas H. Z Naturforsch [C]. 44:173-6 (1989).

S0047 Salsoline 25 mgC11H15NO2 FW 193.24 [89-31-6] 100 mgSalsoline, a tetrahydroisoquinolone, is an active metabolite of dopamine. It inhibits cholinesterase activity.Sallstrom Baum S, Hill R, Kiianmaa K, Rommelspacher H. Alcohol. 1:165-9 (1999).

Maizel EB, Rozengart EV, Khakimov IuP et al. Biokhimiia. 43:1150-6 (1978).

NH

HO

H3CO

CH3

NH

H3CO

H3CO

CH3

HN

HO

HO

OH

.H2SO4

2

c[Cys-Ser-Asn-Leu-Ser-Thr-

Cys]-Val-Leu-Gly-Lys-Leu-Ser-

Gln-Glu-Leu-His-Lys-Leu-Gln-

Thr-Tyr-Pro-Arg-Thr-Asn-Thr-

Gly-Ser-Gly-Thr-Pro-NH2

OH

O ! -D-glucose

O

O

CO2HOH

H O

OH H

H

OHH

OH

CH2OH

H

OH O

H H

H

OHH

O

CH3

H

O

HOCH2

CH3 CH3

OH

H

CH3

CH3

H

CH3

H3C

O

HN

HO

HO

OH


S0200 SAMs Peptide 0.5 mgC74H131N29O18S2 FW 1779.18 [125911-68-4] 1 mgA synthetic peptide often used to determine AMP-activated protein kinase activity. 2.5 mgKishimoto A, Ogura T, Esumi H. Mol Biotechnol. 32: 17-21 (2006).

S0053 α-Santonin 5 gC15H18O3 FW 246.30 [481-06-1] 10 gAn anthelmintic shown to have antiinflammatory, antipyretic and analgesic 25 gactivity comparable to those of the NSAID, diclofenac sodium.

Al-Harbi MM, Ourreshi S, Ahmed MM et al. Japanese J Pharmacol. 64:135-139 (1994).

S0168 Saracatinib 1 mgC27H32ClN5O5 FW 542.03 5 mgHighly selective dual inhibitor of the Src and ABL kinases. Potentially useful for 25 mgdiseases characterized by increased bone resorption.

Hannon RA, Clack G, Rimmer M, et al. J. Bone Miner. Res. 25:463-71 (2010).

S0170 Sarafloxacin Hydrochloride 5 gC20H17F2N3O3

.HCl FW 421.83 [91296-87-6] 10 gA fluoroquinolone antibacterial agent found to be effective against 25 gMycobacterium tuberculosis.

Chu DT, Fernandes PB, Claiborne AK et al. J Med Chem. 28:1558-64 (1985).

Berlin OG, Young LS, Bruckner DA. J Antimicrob Chemother. 19:611-5 (1987).

S0171 Sarafotoxin 6c 0.5 mgC103H147N27O37S5 FW 2515.8 [121695-87-2] 1 mgA selective endothelin subtype B receptor agonist that induces muscle contractions. 2.5 mgFellner SK, Arendshorst W. Am J Physiol Renal Physiol. 292: F175-84 (2007).

S0368 Sarcophine (See page 22 for more information) 10 mgC20H28O3 FW 316.43 [55038-27-2]

It is a cembranoid marine natural product that is reposted to possess cancer chemopreventive properties.

Sarcophine was found to be an effective inhibitor of JB6 cell transformation.

Sawant, S. S.; Youssef, D. T. A.; Reiland, J.; Ferniz, M.; Marchetti, D.; El Sayed, M. D. J. Nat. Prod. 69:1010-1013 (2006).

El Sayed,K. A.;Hamann,M.T.;Waddling,C.A.;Jensen,C.;Lee,S.K.; Dunstan,C. A.; Pezzuto,J.M. J.Org.Chem.63:7449-7455(1998).

Katsuyama,I.;Fahmy,H.;Zjawiony,J.K.;Khalifa,S.I.;Kilada,R.W.;Konoshima,T.;Takasaki,M.;Tokuda,H.J.Nat.Prod.65:1809-1814(2002).

Sawant, S. S.; Sylvester, P. W.; Avery, M. A.; Desai, P.; Youssef, D. T. A.; El Sayed, K. A. J. Nat. Prod. 67:2017-2023 (2004).

2-epi-16-deoxysarcophine (See Deoxysarcophine, 2-epi-16-)

S0278 Satraplatin 5 mgC10H22Cl2N2O4Pt FW 500.28 [129580-63-8] 10 mgAn orally active novel platinum IV anticancer agent. It shows 50 mgpromise against lung cancer and ovarian cancer.

Bengtson EM, Rigas JR. Drugs. 58 Suppl 3:57-69 (1999).

Piccart MJ, Lamb H. Vermorken JB. Ann Oncol. 12:1195-203 (2001).

S0381 Sauvagine 0.5 mgC202H347N56O63S FW 4599.4 [74434-59-6] 1 mgA frog skin peptide that has been shown to inhibit production of prolactin. 2.5 mgFalaschi P, D'Urso R, Negri L et al. Endicrinology. 111: 693-695 (1982).

O

O

CH3

O

CH3

CH3

HN

N N

F

O

COOH

F

.HCl

Pt

O

O

Cl

Cl

H3N

NH2

O

CH3

CH3

O

H-Cys-Thr-Cys-Asn-Asp-Met-

Thr-Asp-Glu-Glu-Cys-Leu-Asn-

Phe-Cys-His-Gln-Asp-Val-Ile-

Trp-OH


pGlu-Gly-Pro-Pro-Ile-Ser-Ile-

Asp-Leu-Ser-Leu-Glu-Leu-Leu-

Arg-Lys-Met-Ile-Glu-Ile-Glu-

Lys-Gln-Glu-Lys-Glu-Lys-Gln-

Gln-Ala-Ala-Asn-Asn-Arg-Leu-

Leu-Leu-Asp-Thr-Ile-NH2

H-His-Met-Arg-Ser-Ala-Met-

Ser-Gly-Leu-His-Leu-Val-Lys-

Arg-Arg-OH

O

O

CH3

CH3

CH3

O

CH3

N

N

HNO

ON

N

O

O

Cl

O


S0830 R(+) Schisandrin A 5 mgR(+) Schizandrin A; R(+) deoxyschisandrin A; R(+) deoxyschizandrin A 10 mgC24H32O6 FW 416.51 m.p. 117-1180C [61281-38-7][a]D:+1100 (C=1.15, CHCl3)

S0831 S(-) Schisandrin B 5 mgS(-) Schizandrin B; S(-)-schisandrin; S(-) wuwei zi su; gomisin N 10 mgC23H28O6 FW 400.47 m.p. 100-1020C [61281-37-6][a]D:-510 (c=0.15, CHCl3)Schisandrin B shows antioxidant activity which may be responsible for its hepatic protecting activity.

It also increases glutathione level and Dt-diaphorase enzyme activity.

Lee IS, Lee HK, Dat NT. Planta Med. 69:63-4 (2003).

Chen DF, Zhang SX, Xie L et al. Bioorg Med Chem. 5:1715-23 (1997).

Ip SP, Yiu HY, Ko KM. Mol Cell Biochem. 208:151-5 (2000).

S0930 Schisantherin A 5 mgSchizantherin A; Gomisin C; Wuweizi ester A 10 mgC30H32O9 FW 536.57 m.p. 116-1180C [58546-56-8][a]D:-190.90 (c=0.995, CHCl3)A lignan from Schisandra chinensis. It has shown a positive effect in lowering the serum

glutamic-pyruvic transaminase level of patients suffering from chronic viral hepatitis.

Liu CS, Fang SD, Huang MF. Sci Sin. 21:483-502 (1978).

S1058 Scopolamine N-butylbromide 1 gHyoscine butylbromide 5 gC21H30BrNO4 FW 440.38 [149-64-4]An antispasmodic agent.

Ayre-Smith G. Acta Radiol Diagn (Stockh). 17:701-13 (1976).

S1059 Scopolamine Hydrobromide 1 gC17H21NO4

.HBr.3H2O FW 438.32 [114-49-8] 5 gAn anticholinergic agent. 25 gDe Souza H, Palermo-Neto J. Gen Pharmacol. 16:533-6 (1985).

S1060 SCPA 1 mgSmall cardioactive peptide A 2 mgC59H92N18O12S FW 1277.57 [98035-79-1] 5 mgA neuropeptide that modulates neuromuscular synapsis in Aplysia.

Fox LE, Lloyd PE. J Neurophysiol. 83:1567-79 (2000).

S1061 SCPB 1 mgSmall cardioactive peptide B 2 mgC52H80N14O11S2 FW 1141.43 [84746-43-0] 5 mgAn antagonistic inhibitor of cAMP-dependent Cl- current in sensory neurons of Aplysia via activation of protein kinase A.

Buttner N, Siegelbaum SA. J Neurophysiol. 90: 586-98 (2003).

S1069 Scriptaid 1 mgC18H18N2O4 FW 326.35 5 mgAn inhibitor of histone deacetylase found to decrease tumor growth. Shown to disrupt

the intracellular protein aggregate transport associated with ALS.Keen JC, Yan L, Mack KM et al. Breast Cancer Res Tr. 81:177-186 (2003).

Corcoran LJ, Mitchison TJ, Liu Q. Curr Biol. 14:488-492 (2004).

CH3

CH3

H3CO

H3CO

H3CO

H3CO

H3CO

H3CO

CH3

CH3

H3CO

H3CO

H3CO

H3CO

O

O

OH

CH3

CH3

H3CO

H3CO

H3CO

H3CO

O

O

O

O

H-Ala-Arg-Pro-Gly-Tyr-Leu-

Ala-Phe-Pro-Arg-Met-NH2

H-Met-Asn-Tyr-Leu-Ala-Phe-

Pro-Arg-Met-NH2

N

HN

OH

OO

O

N

O

O

CH3

OH

O

HBr.3H2O

NCH3

H3C

O

O

OH

O

BrH


S1343 Ac-S-D-K-P 5 mgC20H33N5O9 FW 487.51 [120081-14-3] 10 mgA synthetic hemopeptide shown to inhibit hematopoietic proliferation in 25 mg stem cells.Dai G, Huang C, Li Y, Pi YH, Wang BH. Cell Biol Int. 30: 514-20 (2006).

S1810 Secnidazole 5 gC7H11N3O3 FW 185.18 [3366-95-8] 10 gAn antimicrobial used as amoebecide and trichomonacide. 25 gBenazet F, Guillaume L. Bull Soc Pathol Exot Filiales. 69:309-19 (1976).

Gillis JC, Wiseman LR. Drugs. 51:621-38 (1996).

S1604 Secretin Acetate Please inquire

C130H220N44O41 FW 3055.41 [10813-74-8]

S1605 Secretin, human 1 mgC130H220N44O40 FW 3039.4 [108153-74-8] 2 mgSecretin is a polypeptide gastrointestinal hormone. It stimulates exocrine 5 mg pancreatic secretion.Chey WY, Chang TM. J Gastroenterol. 38:1025-35 (2003).

Konturek SJ, Thor P, Dembinski A et al. Gastroenterology. 68:1527-35 (1975).

S1606 Secretin, porcine 5 mgC130H220N44O41 FW 3055.4 [17034-35-4] 10 mg

25 mg

S1607 Secretin, rat 0.5 mgC129H216N42O42 FW 3027.42 [121028-49-7] 1 mg

2.5 mg

S1609 Securinine (See page 21 for more information) 500 mgC13H15NO2 FW 217.26 [5610-40-2] 1 gA g-aminobutyric acid (GABA) receptor antagonist. Recently, it was found to induce apoptosis in human leukemia HL-60 cells.Beutler JA, Karbon EW, Brubaker AN et al. Brain Res. 330:135-40 (1985).

Dong NZ, Gu ZL, Chou WH, Kwok CY. Chung Kuo Yao Li Hsueh Pao. 20:267-70 (1999).

S1612 Sedanolide 100 mg (3-Butyl-3a,4,5,6-tetrahydro-1(3H)-isobenzofuranone) 500 mgC12H18O2 FW 194.27 m.p. 30-310C [6415-59-4] 1 gNatural product isolated from celery seed oil. Inducer of glutathione S-transferase

enzyme system. Inhibitor of chemically induced carcinogenesis.

Zheng G-q, Kenney, PM, Lam LKT. Nutr. Cancer. 19:77-86 (1993).

S1843 L-Selectin 1 mgC62H105N16O18S2 FW 1426.75 [126880-86-2] 2 mgA glycoprotein receptor that mediates lymphocyte rolling in high 5 mgendothlial venules.Sperandio M, Frommhold D, Babushkina I and Ellies LG et. al. Eur J Immunol. 36: 3207-15 (2006).

NCH3

N

CH3

OH

O2N

O

CH3

O

H-His-Ser-Asp-Gly-Thr-Phe-Thr-

Ser-Glu-Leu-Ser-Arg-Leu-Gln-

Asp-Ser-Ala-Arg-Leu-Gln-Arg-

Leu-Leu-Gln-Gly-Leu-Val-NH2

His-Ser-Asp-Gly-Thr-Phe-Thr-

Ser-Glu-Leu-Ser-Arg-Leu-Arg-



His-Ser-Asp-Gly-Thr-Phe-Thr-


Glu-Gly-Ala-Arg-Leu-Gln-Arg-


H-Cys-Gln-Lys-Leu-Asp-Lys-

Ser-Phe-Ser-Met-Ile-Lys-OH

H-His-Ser-Asp-Gly-Thr-Phe-Thr-




Ac-Ser-Asp-Lys-Pro-OH

N

OO

H


S1845 L-(+)-Selenomethionine (See page 12 for more info) 10 mg2-Amino-4-(methylseleno)butanoic acid 25 mgC5H11NO2Se FW 196.11 m.p. 2650C [3211-76-5] 100 mgInhibitor of 2-acetylaminofluorene-induced hepatocarcinogenesis.

Mukherjee B, Ghosh S, Chatterjee M. J Exp Ther Oncol. 14:209-217 (1996).

S1848 Se-methylseleno-L-cysteine (See page 12 for more info) 100 mg2-Amino-3-methylselenyl propionic acid 250 mgC4H9NO2Se FW 182.08 [26046-90-2]

Inhibitor of DMBA-induced mammary tumors.

Ip C, Ganther HE. Carcinogenesis. 7:1167-1170 (1992).

S1968 Seratrodast 25 mgC22H26O4 FW 354.44 [112665-43-7] 100 mgIs a thromboxane receptor antagonist used primarily in the treatment of asthma. 250 mgFukuoka, T. Journal of Asthma (2003), 40(3), 257-264

S1969 Sermorelin Acetate Please inquireC149H246N44O42S FW 3358.03 [86168-78-7]Secretin stimulates the secretion of bicarbonate by the pancreas and inhibits the production of gastrin and acid production in the stomach. It also potentiates the release of digestive enzymes

from the pancreas triggered by cholecystokinin. Diagnosis of pancreatic dysfunctionand the presence of a gastrinoma treating. For the treatment of autism-not yet approved applications.

S1971 Sertraline HCl 500 mgC17H17Cl2N. HCl FW 342.70 [79559-97-0] 1 gSertraline Hydrochloride is a selective serotonin reuptake inhibitor (SSRI) used as 5 gan antidepressant.

Owens MJ, Morgan WN, Plott SJ, et al. J. Pharmacol. Exp. Ther. 283:1305-1322 (1997).

S1970 Serum Thymic Factor 1 mgC33H54N12O15 FW 858.89 [63958-90-7] 2 mgA thymic peptide hormone that induces the formation of E rosettes. 5 mgIncefy GS, Mertelsmann R, Yata K, Dardenne M, Bach JF, Good RA. Haematologia (Budap). 13: 203-11 (1980).

S2044 S-F-L-L-R 1 mgC30H50N8O7 FW 634.78 2 mgA protease-activated receptor 1 agonist peptide that exhibits cell 5 mgproliferation effects.Hirota Y, Osuga Y, Hirata T and Yoshino O et. al. J Clin Endocrinol Metab. 90: 3673-9 (2005).

S3033 Shikimic acid 1 gC7H10O5 FW 174.15 [138-59-0] 5 gAn antimicrobial agent with antagonistic effects. It inhibits rapamycin biosynthesis in Streptomyces hygroscopicus.Ma Y, Xu QP, Sun JN et al. Chung Kuo Yao Li Hsueh Pao. 20:701-4 (1999).

Fang A, Demain AL. Folia Microbiol (Praha). 40:607-10 (1995).

S3313 Sildenafil Citrate 50 mgC28H38N6O11S FW 666.70 [171599-83-0] 250 mgA phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction and 1 gpulmonary arterial hypertension. It has also been found useful for the prevention and

treatment of altitude sickness.

Richalet JP, Gratadour P, Robach P, et al. Am. J. Respir. Crit. Care Med. 171: 275–81 (2005).

COOHHO

HO

OH

NH2

Se

O

HO

CH3

HO

O

NH2

Se

CH3

pGlu-Ala-Lys-Ser-Gln-Gly-Gly-

Ser-Asn-OH

Tyr-Ala-Asp-Ala-Ile-Phe-Thr-

Asn-Ser-Tyr-Arg-Lys-Val-Leu-

Gly-Gln-Leu-Ser-Ala-Arg-Lys-

Leu-Leu-Gln-Asp-Ile-Met-Ser-

Arg-NH2

H-Ser-Phe-Leu-Leu-Arg-OH

O

O

H3C

H3C

CH3

O

OH

H

HHN

Cl

Cl

HCl

N

N

N

N

O

SN

NO

OO

HO2C

HO CO2H

CO2H


S3346 Silodosin 25 mgC25H32F3N3O4 FW 495.53 [160970-54-7] 100 mgA potent and highly selective antagonist of human alpha 1a-adrenoceptor. 500 mgShibata K, Flglar R, Horie K, et al. Mol Pharmacol 48:250-8 (1995).

S3343 Silybin 500 mgC25H22O10 FW 482.44 [22888-70-6] 1 gThe major component of silymarin, a group of polyphenolic flavonoids derived 5 g from milk thistle (Silybum marianum) that has anti-inflammatory, cytoprotective and

anti-carcinogenic effects . It is reported that Silybin has protective effect against skin cancer and inhibits mitogen-activated protein kinase.Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB. J Immunol. 163:6800-9 (1999).

Zi X, Agarwal R, Biochem Biophys Res Commun. 263:528-36 (1999).

S3345 Silymarin (See page 14 for more information) 10 gC25H22O10 FW 482.44 [65666-07-1] 50 gFlavanoid antioxidant isolated from milk thistle that is effective chemopreventive agents.Steele VE, Kelloff GJ, Wilkinson BP, Arnold JT. Cancer Res. 50:2068-2074 (1990).

Zi X, Mukhtar H, Agarwal R. Biochem Biophys Res Commun. 239:334-9 (1997).

S3449 Simvastatin (See page 26 for more information) 50 mgSynvinolin 100 mgC25H38O5 FW 418.57 m.p. 135-1380C [79902-63-9] 500 mgA potent HMG-CoA reductase inhibitor and hypocholesterolemic agent. Inhibits

cell proliferation of human glioma cells and of acute myeloid leukemia cells.

Anti-carcinogenic during the promotion phase of radiation-induced mammary tumors.Inano H, Suzuki K, Onoda M. Wakabayashi K Carcinogenesis. 18:1723-7 (1997).

Kikuchi T, Nagata Y, Abe T. J Neurooncol. 34:233-9 (1997).

Lishner M, Bar-Sef A, Elis A, Fabian I. J Investig Med. 49:319-24 (2001).

Mol, MJ et al. Lancet. 2:936 (1986).

S3351 Sincalide (CCK-8) 0.5 mgC49H62N10O16S3 FW 1143.29 [25126-32-3] 1 mgSincalide corresponds to the C-terminal octapeptide of cholecystokinin (CCK) which acts on

receptors within the gallbladder wall causing it to contract.

S3353 Sinomenine HCl 10 gC19H23NO4

.HCl FW 365.86 [6080-33-7] m.p. 1620C 25 gSinomenine is an alkaloid isolated from the Chinese medicinal plant 50 gSinomenium acutum. It has immunomodulating and anti-inflammatory activities.

Its anti-arthritic property is related to the antiproliferative effects on synovial fibroblasts

and lymphocytes. Other antirheumatic mechanisms are attributed to its ability to decrease

PGE2 and leukotriene C4 synthesis, and inhibit NO production.Vieregge B, Resch K, Kaever V. Planta Med. 65:80-82 (1999).

Liu L, Buchner E, Beitze D et al. Int J Immunopharmacol. 18:529-43 (1996).

Candinas D, Mark W, Kaever V et al. Transplantation. 62:1855-1860 (1996).

Liu L, Resch K, Kaever V. Int J Immunopharmacol. 16:685-691 (1994).

Liu L. Riese J, Resch K, Kaever V. Arzneimittelforsching. 44:1223-1226 (1994).

S3476 Sitagliptin Phosphate Monohydrate 10 mgC16H15F6N5O .H3PO4 .H2O FW 523.32 [654671-77-9] 25 mgSitagliptin is a competitive inhibitor of the enzyme dipeptidyl peptidase (DPD-4) 100 mgand is used as an orally active antihyperglycemic agent.

Kim, D., et al.: J. Med. Chem. 48, 141 (2005)

OH

HOH

OH

HOO

O

O

H

CH2OH

H

OH

OCH3

OO

O

OCH3

OH

OOH

HO

H

H

OH

H

H

CH2OH

Asp-Tyr(SO3H)-Met-Gly-Trp-Met-

Asp-Phe-NH2

HO

O

OHO

O

OCH3

O

HN

HO

OH3C

CH3

.HCl

H2N

OHN

O

O

N

HO

F F

F

F

F

F

N

ONH2

NN

N

FF

F

H2O H3PO4


S3584 Sivelestat Sodium Tetrahydrate 5 mgC20H21N2O7S.Na.4H2O FW 528.51 [201677-61-4] 25 mgIs an inhibitor of human neutrophil elastase.

Kawabata K, Suzuki M, Sugitani M, Imaki K, Toda M, Miyamoto T (June 1991).

Biochem. Biophys. Res. Commun. 177 (2): 814–20.

S3585 SIVmac239-1 1 mgC65H115N21O23S1 FW 1590.83 2 mgA pathogenic molecular clone of simian immunodeficiency virus (SIV). 5 mgLuciw PA, Pratt-Lowe E, Shaw KE, Levy JA, Cheng-Mayer C. Proc Natl Acad Sci U S A. 92: 7490-4 (1995).

S3586 SIVmac239-2 1 mgC70H123N19O25 FW 1630.87 2 mg

5 mg

S5200 SNA 1 1 mgSNA 1 is a four chain lectin isolated from the bark of the common elder. It is a ribosome-inactivating protein with low activity on mammalian ribosomes.Broekaert WF et al. Biochem J. 221:163 (1984).

VanDamme EJM et al. Eur J Biochem. 235:128 (1996).

SB5776 Snake venom - Bothrops alternatus (urutu) 100 mgKnown for myotoxic activity. Bothroalternin isolated from

the venom is a new thrombin inhibitor.Arruda EZ, Silva NM, Moraes RA, Melo PA. Braz Jmed Biol Res. 35:723-726 (2002).

Castro HC, Dutra DL, Oliveira-Carvalho AL, Zingali RB. Toxicon 36:1903-12 (1998).

SB5778 Snake venom - Bothrops neuwiedi diporous 100 mg

SC7056 Snake venom - Crotalus durissus terrificus 100 mgA potent neurotoxin. Crotoxin (CT), a phospholipase A2 (PLA2) derivedfrom the venom is a heterodimeric protein. PLA2 is found to have anti-proliferative activity.Hawgood BJ. Toxicon 39:1277-82 (2001).

Donato NJ, Martin CA, Perez M, Newman RA, Vidal JC, Etcheverry M. Biochem Pharmacol. 51:1535-43 (1996).

S5746 Solanesol 50 mgC45H74O FW 631.07 [13190-97-1] 100 mgA trisesquiterpene alcohol present in tobacco leaf. It is a possible 500 mgprecusor of polycyclic aromatic hydrocarbons.Severson RF, Ellington JJ, Schlotzhauer PF et al. J Chromatogr. 139:269-82 (1977).

S5745 [Tyr1] Somatostatin 1 mgC82H108N18O20S2 FW 1730.01 [59481-23-1] 2 mg

5 mg

S5747 [Tyr11] Somatostatin 1 mgC76H102N18O20S2 FW 1651.91 [59481-27-5] 2 mg

5 mg

S5749 Somatostatin-14 5 mgC76H104N18O19S2 FW 1637.92 [51110-01-1]] 10 mgGrowth hormone-release inhibiting factor. It affects cell proliferation. 25 mgInduces apoptosis in MCF-7 human breast cancer cells.Patel YC. Front Neuroendocrinol. 20:157-98 (1999).

Hocker M. Wiedenmann B. Ital J Gastroenteril. 31 Suppl 2:S139-42 (1999).

Thangaraju M, Sharma K, Liu D et al. Cancer Res. 59:1649-54 (1999).

HO

CH3 CH3CH3 CH3

CH3

H3C CH3

CH3 CH3 CH3

H-Tyr-Gly-Cys-Lys-Asn-Phe-

Phe-Trp-Lys-Thr-Phe-Thr-Ser-

Cys-OH

(Cys3-Cys14)

H-Ala-Gly-Cys-Lys-Asn-Phe-

Phe-Trp-Lys-Thr-Tyr-Thr-Ser-

Cys-OH

(Cys3-Cys14)

H-Met-Gly-Val-Arg-Asn-Ser-

Val-Leu-Ser-Gly-Lys-Lys-Ala-

Asp-Glu-OH

H-Asn-Ser-Val-Leu-Ser-Gly-

Lys-Lys-Ala-Asp-Glu-Leu-Glu-

Lys-Ile-OH

Ala-Gly-Cys-Lys-Asn-Phe-Phe-

Trp-Cys-Ser-Thr-Phe-Thr-Lys

(Cys3-Cys14, Phe7-Thr10)

OHN

O

OHN

S

O

O

O

O

NaH2O

4


S5751 Somatostatin-25 0.5 mgC127H191N37O34S3 FW 2876.36 [76461-17-1] 1 mg

2.5 mg

S5750 Somatostatin-28 1 mgC137H207N41O39S3 FW 3148.6 [75037-27-3]

S5752 Somatostatin-28 (1-12) 1 mgC49H81N17O19S1 FW 1244.36 [81286-16-0] 2 mg

5 mg

S5753 Somatostatin-28 (1-14) 1 mgC61H105N23O21S FW 1528.72 [79243-10-0] 2 mg

5 mg

S5754 Somatostatin Acetate Please inquireC76H104N18O19S2 FW 1637.88 [378916-34-6]

S5868 Sorafenib (See page 29 for more information) 25 mgC21H16ClF3N4O3 FW 464.82 [284461-73-0] 100 mgSorafenib is a small molecular inhibitor of several protein kinases. Protein kinases are overactive in many of the molecular pathways that cause cells to become cancerous.Yang, F. Molecular Cancer Therapeutics (2008), 7(11), 3519-3526.

S5869 Sorafenib Tosylate 25 mgC21H16ClF3N4O3

. C7H8O3S FW 637.03 [475207-59-1] 100 mg

A Tyrosine protein kinase inhibitor (VEGFR and PDGFR). It is used for the 250 mgtreatment of kidney and liver cancers.

Wilhelm SM, et. al. Molecular Cancer Therapeutics 7 (10): 3129–40.

S5976 Sotalol HCl 25 mgC12H20N2O3S. HCl FW 308.82 [959-24-0] 100 mgIs a hypertension and cardiac arrhythmias. Inhibits the potassium channels in 250 mg the heart. The L-form of this compound is also a beta blocker. de Graaf, C. Journal of Medicinal Chemistry (2008), 51(20), 6620.

S6000 Sparfloxacin (See page 16 for more information) 500 mgC19H22F2N4O3 FW 392.40 [110871-86-8] 1 gA fluoroquniolone antibacterial, acts on DNA gyrase.

Piddock LJ, Zhu M. Antimicrob Agents Chemother. 35:2423-7 (1991).

S6018 Spectinomycin hydrochloride 5 gC14H24N2O7

.2HCl.5H2O FW 495.25 [22189-32-8] 25 gA broad-spectrum aminocyclitol antibiotic that is highly effective in the treatment of gonorrhea.

It has shown neuromuscular blocking activity by a predominant action on acetylcholine release.

Singh YN, Marshall IG, Harvey AL. Clin Exp Pharmacol Physiol. 6:159-65 (1979).

Holloway WJ. Med Clin North Am. 66:169-73 (1982).

O

O OHN

HO

NH

H

OH

OH

O

Ser-Ala-Asn-Ser-Asn-Pro-Ala-

Met-Ala-Pro-Arg-Glu-Arg-Lys-

Ala-Gly-Cys-Lys-Asn-Phe-Phe-

Trp-Lys-Thr-Phe-Thr-Ser-Cys


H-Ser-Ala-Asn-Ser-Asn-Pro-

Ala-Met-Ala-Pro-Arg-Glu-OH

H-Ser-Ala-Asn-Ser-Asn-Pro-

Ala-Met-Ala-Pro-Arg-Glu-Arg-

Lys-OH

H-Ser-Asn-Pro-Ala-Met-Ala-

Pro-Arg-Glu-Arg-Lys-Ala-Gly-

Cys-Lys-Asn-Phe-Phe-Trp-

Lys-Thr-Phe-Thr-Ser-Cys-OH

(Cys14-Cys25)

Ala-Gly-c[Cys-Lys-Asn-Phe-Phe-

Trp-Lys-Thr-Phe-Thr-Ser-Cys]

Cl

FFF

HN

HN

OO

NHN

O

CH3

N N

O

CO2HF

F

NH2

HN

CH3

H3C

HN CH3

OH

CH3H3C

SNH

O O

HCl

NH

NH

OO

N

O

NH

CF3

Cl

S OH

O

O


S6019 Speract 1 mgC38H57N11O14 FW 891.94 [76901-59-2] 2 mgA peptide associated with eggs of sea urchin, Lytechinus pictus. It has been 5 mgshown ot bind to the plasma membrane receptor of spermatozoa and stimulate sperm respiration.

Repaske DR, Garbers DL. J Biol Chem. 258: 6025-9 (1983).

S6129 D-Sphingosine 5 mgC18H37NO2 FW 299.49 [123-78-4] 25 mgIt induces apoptosis by inhibiting protein kinase. It is also reported to cause inhibition

of adrenaline stimulated cyclic AMP accumulation, permeation of cells and making them leaky

to ATP, inhibition of adrenaline-stimulated adenylate cyclase inhibition of cyclic AMP.

Souktani R, Berdeaux A, Ghaleh B et al. Am J Physiol cell Physiol. 2797:C158-65 (2000).

Ju TZ, Chen HL, Gu JX, Qin H. Glycoconj J. 12:767-72 (1995).

Johnson JA, Clark RB. Biochem J. 268:507-11 (1990).

S6131 Sphingosine, N, N-dimethyl 5 mgC20H41NO2 FW 327.5 [119567-63-4]A general modulator of protein kinases. Inhibites protein kinase C and stimulates src kinase; induces apoptosis in human leukemia HL-60 cells. Igarashi Y et al. J Biol Chem. 265:5385 (1990).

S6130 Sphingosine 1-phosphate 1 mgC18H38NO5P FW 379.47 [26993-30-6]Ligand for a family of specific G-protein that regulates a wide variety of important cellular functions,

including vascular maturation, angiogenesis, apoptosis, cell growth, survival, cytoskeletal rearrangement and cell motility by divergent pathways.Spiegel S, Milstien S. Biochem Soc trans. 31:1216-9 (2003).

S6134 Spinorphin, bovine 5 mgC45H64N8O10 FW 877.06 [137201-62-8] 10 mgAn endogenous factor that exhibits inhibitory effects on enkephalin-degrading 25 mg enzymes.Yamamoto Y, Ono H, Ueda A, Shimamura M, Nishimura K, Hazato T. Curr Protein Pept Sci. 3: 587-99 (2002).

S6232 Spiramycin 1 gFW 842.05 [8025-81-8] 5 gA macrolide antibiotic. It has been shown to decrease the replication index of humanlymphocytes.

Rencuzogullari E, Ila HB, Topatkas M et al. Teratogenesis Carcinogenesis Mutagenesis. 22:51-58 (2002).

S6234 Spiramycin Embonate 1 gC23H16O6

. Unspecified FW 1231.43 [67724-08-7] 5 g

S6233 Spiramycin Hexanedioate 1 gSpiramycin Adipate 5 g[11034-40-5]

S6168 Spirapril Hydrochloride 100 mgC22H30N2O5S2 FW 466.61 [83647-97-6] 250 mgSelectively suppresses the renin-angiotensin-aldosterone system; inhibits ACE, 1 g prevents conversion of angiotensin I to angiotensin II; results in dilation of arterial and venous vessels.Smith, Elizabeth M. Journal of Medicinal Chemistry (1989), 32(7), 1600-6.

CH2OH

N(CH3)2

OH

(CH2)12CH3

O

O

ORH3C

H3CO

O

CH3

CH

O

N

CH3

CH3CH3

O

O O

N CH3

H3C

CH3

O

O

OH

CH3

OH

CH3

HO

Spiramycin I R = HSpiramycin II R = COCH3Spiramycin III R = COCH2CH3

O

O

ORH3C

H3CO

O

CH3

CH

O

N

CH3

CH3CH3

O

O O

N CH3

H3C

CH3

O

O

OH

CH3

OH

CH3

HO

, C6H10O4

Adipic spiramycin I R = HAdipic spiramycin II R = COCH3Adipic spiramycin III R = COCH2CH3

O

O

ORH3C

H3CO

O

CH3

CH

O

N+

CH3CH3

O

O O

N+ CH3

CH3

O

O

OH

CH3

OHCH3

HO

Spiramycin I Embonate R = HSpiramycin II Embonate R = COCH3Spiramycin III Embonate R = COCH2CH3

H H

H

H

H

O

-O

HO

HO

-O

OH

H

H

HH

H

H

CH3

H

CH3H

(H2C)12H3C

OH

NH2

OH

H-Gly-Phe-Asp-Leu-Asn-Gly-

Gly-Gly-Val-Gly-OH

H-Leu-Val-Val-Tyr-Pro-Trp-

Thr-OH

S

SN

O

HN

CO2EtCO2H

C C(H2C)12H3CHC CHCH2O

OHNH2

H

H

P OH

O

OH


S6235 Spironolactone 1 gC24H32O4S FW 416.57 [52-01-7] 5 gAn aldosterone antagonist. It directly interferes with the biosynthesis of

aldosterone in bovine and certain human adrenal cortical tissue.

Cheng SC, Suzuki K, Sadee W et al. Endocrinology. 99:1097-106 (1976).

Bendtzen K, Hansen PR, Rieneck K. Clin Exp Immunol. 134:151-8 (2003).

S7080 SR Poly Caspases Assay Kit 25 TestsSR-VAD-FMK 100 Tests

S7081 SR Caspases 3 and 7 Assay Kit 25 TestsSR-DEVD-FMK 100 Tests

S7082 SR Caspase 9 Assay Kit 25 TestsSR-LEHD-FMK 100 Tests

S7083 SR-101-Phe-CMK FLISPTM Assay Kit 25 TestsSFCK 100 Tests

S7084 SR-101-Leu-CMK FLISPTM Assay Kit 25 TestsSLCK 100 Tests

S7701 Stanozolol 1 gC21H32N2O FW 328.49 [10418-03-8] 5 gAn anabolic-androgenic steroid, induces apoptotic cell death in adult rat ventricular myocytes.

Zaugg M. Jamali NZ. Lucchinetti E. et al J Cell Physiol. 187:90-5 (2001).

S7600 Staurosporine 1 mgC28H26N4O3 FW 466.5 [62996-74-1] 5 mgA protein kinase C inhibitor that induces apoptosis in many cell types. Experimental results

obtained in a cell-free assay suggest that cytoplasmic proteins directly modulated by staurosporine

may be involved in signaling the induction of DNA fragmentation and apoptosis.

Romanova D, Novotny L, Sedlak J et al. Neoplasma. 45: 204-9. (1998).

Zhang H, Hoang T, Saeed B, Ng SC. Prostate. 29:69-76 (1996).

Bertrand R, Solary E, O'connor P et al. Exp Cel Res. 211:314-21 (1994).

S7603 Stavudine 100 mgC10H12N2O4 FW 224.21 [3056-17-5] 250 mgIs a nucleoside analog reverse transcriptase inhibitor active against HIV. 1 gStavudine triposphate inhibits HIV reverse transcriptase and terminates DNA synthesis.

Liu, Lian Jin. Bulletin of the Korean Chemical Society (2008), 29(9), 1723-1728.

Byakika-Kibwika, P. Journal of Antimicrobial Chemotherapy (2008), 62(5), 1113-1117.

S7717 Sterigmatocystin 1 mgC18H12O6 FW 324.28 [10048-13-2] 5 mgMycotoxin produced by strains of the common molds. Induces sister chromatid 10 mgexchanges in bone marrow cells of mice. It causes necrosis of the liver and kidney

and has an inhibitory effect on orotic acid incorporation into nuclear RNA.

Curry PT et al. Mutat. Res. 137:111 (1984).

Terao K Acta Pathol. Jpn. 23:647-53 (1973).

Nel W, Pretorius HE Biochem. Pharmacol. 19:957-9 (1970).

O

H H

H

H3CO

O

CH3

SCH3

O

O OH

O

OCH3O

O

O

HN

NO

O

CH3

HO

CH3

CH3

H

H H

CH3

H

N

NH

OH

NH

O

N

N

O

H

HN

O


S7769 Streptomycin sulfate 25 g(C21H39N7O12)2

.3H2SO4 FW 1457.39 [3810-74-0] 50 gAn aminosugar containing antibiotic from Streptomyces griseus. It was the 100 g first antibiotic used for the treatment of tuberculosis. Its mechanism of action is the inhibition of ribosome protein synthesis.Kornder JD. Med Hypotheses. 58:34-46 (2002).

S7870 Streptozocin 50 mgStreptozotocin; N-(methyl-nitrosocarbamoyl)-a-D-glucosamine 100 mgC8H15N3O7 FW 265.22 [18883-66-4] 500 mgAn antitumor agent, used primarily for the treatment of pancreatic cancers. DuPriest RW Jr., Huntington MC, Massey WH et al. Cancer. 35:358-367 (1975).

S7871 Stresscopin, human 0.5 mgC195H326N56O53S2 FW 4367.24 [352020-03-2] 1 mgA neuropeptide with high affinity for type 2 corticotropin-releasing factor 2.5 mgreceptor. It is a potent regulator of cardiovascular functions.Nazarloo HP, Buttrick PM, Saadat H, Dunn AJ. Curr Protein Pept Sci. 7: 229-39 (2006).

S7872 Stresscopin-Related Peptide, human 0.5 mgC205H358N68O57 FW 4687.56 [348626-74-4] 1 mgA type 2 corticotropin-releasing factor receptor agonist. 2.5 mgGardiner SM, March JE, Kemp PA, Bennett T. J Pharmacol Exp Ther. 321: 221-6 (2007).

S7970 Strontium Ranelate 1 gC12H6N2O8SSr2 FW 513.49 [135459-87-9] 5 gA medication for osteoporosis. It is unusual in the sense that it both increases

deposition of new bone osteoblasts and reduces the resorption of bone by osteoclasts. It is therefore promoted as a "dual action bone agent" (DABA).Fuchs, R. K. Osteoporosis International (2008), 19(9), 1331-1341.

S8005 Substance P 5 mgC63H98N18O13S1 FW 1347.66 [33507-63-0] 10 mgA neurotransmitter peptide that is distributed in sensory nerve fibers, bone, 25 mgand bone-related tissue. It is involved in pain signal transmission and modulates the function of inflammatory and immune responses.Michalski CW, Autschbach F, and Selvaggi F et. al. Am J Surg. 193: 476-81 (2007).

Corcoran KE, Patel N, Rameshwar P. J Immunol. 178: 2075-82 (2007).

Monnikes H, van der Voort IR, and Wollenberg B et. al. Digestion 71:111-23 (2005).

S8006 Substance P (1-4) 1 mgC22H40N8O5 FW 496.6 [69355-89-1] 2 mg

5 mg


5 mg


5 mg

S8009 Substance P (7-11) 1 mgC31H44N6O5S1 FW 612.8 [51165-05-0] 2 mg

5 mg

NH

OH

OH

O

HN

HO

CH3

OH

CHOO

OH OO

NHCH3

OH

CH2OH

NH2

H2N

NH

NH

O

HO

HN N

O

N

CH3

O

OH

OH

OH

H-Thr-Lys-Phe-Thr-Leu-Ser-

Leu-Asp-Val-Pro-Thr-Asn-Ile-

Met-Asn-Leu-Leu-Phe-Asn-Ile-

Ala-Lys-Ala-Lys-Asn-Leu-Arg-

Ala-Gln-Ala-Ala-Ala-Asn-Ala-

His-Leu-Met-Ala-Gln-Ile-NH2

H-His-Pro-Gly-Ser-Arg-Ile-Val-

Leu-Ser-Leu-Asp-Val-Pro-Ile-

Gly-Leu-Leu-Gln-Ile-Leu-Leu-

Glu-Gln-Ala-Arg-Ala-Arg-Ala-

Ala-Arg-Glu-Gln-Ala-Thr-Thr-

Asn-Ala-Arg-Ile-Leu-Ala-Arg-

Val-NH2

H-Arg-Pro-Lys-Pro-Gln-Gln-

Phe-Phe-Gly-Leu-Met-NH2

H-Arg-Pro-Lys-Pro-OH


Phe-OH


Phe-Phe-Gly-OH

H-Phe-Phe-Gly-Leu-Met-NH2

S

N

O

O

N

O

O

O

O

Sr2+

O

OSr2+


S8010 [Nle11] Substance P 1 mgC64H100N18O13 FW 1329.62 [57462-42-7] 2 mg

5 mg

S8011 [Pro9] Substance P 0.5 mgC66H102N18O13S1 FW 1387.73 [104486-69-3] 1 mg

2.5 mg

S8012 [Sar9] Substance P 1 mgC64H100N18O13S FW 1361.61 [77128-75-7] 2 mg

5 mg

S8013 [Tyr8] Substance P 1 mgC63H98N18O14S1 FW 1363.66 [55614-10-3] 2 mg

5 mg

S8014 Substance P, Free Acid 5 mgC63H97N17O14S FW 1348.65 [71977-09-8] 10 mg

25 mg

S7908 Suc-APA-pNA 100 mgC21H27N5O8 FW 477.5 1g

S7909 Suc-LEPF-pNA 1 mgC35H44N6O11 FW 724.7 10 mg

S8110 Sucralfate 1 gSucrose Octasulfate-Aluminum Complex FW 974.73 5 gC12H30Al8O51S8

. [Al(OH)3]x.(H2O)y x=8 to 10; y=22 to 3 [54182-58-0]

Is an oral gastrointestinal medicationi primarily used for the treatment of gastroesophageal reflux disease and stress orders. The mechanism of action involves the complex binding to hydrochloric acid in the stomach and forms a paste-like .

substance which provides protection to the stomach lining

Du, Y. Digestive Diseases and Sciences (2008), 53(11), 2886-2895.

S7910 Suc-RGPF-pNA 1 mgC32H41N9O9 FW 695.7 10 mg

Sucrose Octasulfate-Aluminum Complex (See Sucralfate)

S7911 Suc-SDPF-pNA 1 mgC31H36N6O12 FW 684.6 10 mg

S8244 Sulbactam 500 mgC8H11NO5S FW 233.24 [68373-14-8] 1 gA beta-lactamase inhibitor that has similar characteristics as ampicillin. 5 gOften used in combination with other antibiotics.

Wexler HM, Molitoris E, Finegold SM. Antimicrob Agents Chemother. 35:1219-24 (1991).

Foulds G, Stankewich JP, Marshall DC et al. Antimicrob Agents Chemother. 2:692-9 (1983).


Phe-Phe-Pro-Leu-Met-NH2


Phe-Phe-Gly-Leu-Nle-NH2


Phe-Phe-Sar-Leu-Met-NH2


Phe-Tyr-Gly-Leu-Met-NH2


Phe-Phe-Gly-Leu-Met-OH

Suc-Ala-Pro-Ala-pNA

Suc-Leu-Glu-Pro-Phe-pNA

Suc-Arg-Gly-Pro-Phe-pNA

Suc-Ser-Asp-Pro-Phe-pNA

N

S

O

O

OOH

O

O

O O

O

S

OAl(OH)2

O

O

OS

(HO)2AlO

O

O

O

S(HO)2AlO

O

O

O

S

(HO)2AlO

O

O

O

S

OAl(OH)2

O

O

O

S

OAl(OH)2

O O

O

SOAl(OH)2O

O

O

S

(HO)2AlO

O

O

[Al(OH)3]x(H2O)y

x = 8 to 10

y = 22 to 31


S8243 Sulbactam sodium salt 500 mgC8H10NNaO5S FW 255.22 [69388-84-7] 1 g

5 g

S8245 Sulfadiazine 50 gC10H10N4O2S FW 250.28 [68-35-9] 100 gAnti-microbial agent. Its chlorambucil derivative is found to be a potent 500 g antitumor agent.

Huang Z, Yang G, Lin Z, Huang J. Bioorg Med Chem Lett 11:1099-103 (2001).

S8246 Sulfadimethoxine 10 gC12H14N4O4S FW 310.33 [122-11-2] 25 gA sulfonamide antibiotic. 100 gFish JG, Morgan DW, Horton CR. Vet Med Small Anim Clin. 60:1201-3 (1965).

S8144 Sulfadoxine 10 gC12H14N4O4S FW 310.33 [2447-57-6] 25 gAn antibacterial agent. 100 gBohni E, Fust B, Rieder J. Chemotherapy. 14:195-226 (1969).

S8248 Sulfamethoxazole 10 gC10H11N3O3S FW 253.28 [723-46-6] 25 gAn antimicrobial. Used in conjunction with trimethoprim as the first-line 100 g treatment for P. carinii pneumonia.Kovacs JA, Gill VJ, Meshnick S et al. JAMA. 286: 2450-2460 (2001).

Rodriguez MR, Pizzorno MT, Albonico SM. J Pharm Sci. 66:121-123 (1977).

S8247 Sulfasalazine 10 gC18H14N4O5S FW 398.39 [599-79-1] 50 gIt is a disease-modifying antirheumatic drug (DMARD) that inhibits extracelluar 100 g release of proinflammatory secretory phospholipase A2. It was found to induce neutrophil apoptosis and regulate human B cell function.

Pruzanski W, Stefanski E, Vadas P, Ramamurthy NS. Biochem Pharm. 53:1901-1907 (1997).

Akahoshi T, Namai R, Sekiyama N et al. J Leuk Biol. 62:817-826 (1997).

Hirohata S, Ohshima N, Yanagida T, Aramaki K. Int Immunopharm. 2:631-640 (2002).

S8251 Sulfluramid 500 mgC10H6F17NO2S FW 527.20 [4151-50-2] 1 gA delayed-action insecticide. 5 gReid BL, Bennett GW, Barcay SJ. J Econ Entomol. 83:148-152 (1990).

S8044 R,S-Sulforaphane (See pages 7-8 for more information) 25 mg1-Isothiocyanato-4-(methylsulfinyl)-butane, D,L-sulforaphane 50 mgC6H11NOS2 FW 177.29 b.p. 125-1350C (0.01mm) [4478-93-7] 100 mgd=1.183 500 mgSulforaphane is a Phase II enzyme inducer present in brocolli. It was found to

inhibit chemically induced mammary tumor formation in rats. R,S-sulforaphane is a synthetic compound.Zhang Y, Talalay P, Cho CG, Posner GH. Proc Natl Acad Sci USA. 89:2399-2403 (1992).

Zhang Y, Kensler TW, Cho CG et al. Proc Natl Acad Sci USA. 91:3147-3150 (1994).

O

SN C SH3C

F3C(F2C)7 S

O

O

N

H

CH3

NHN

S N N

COOH

OHO O

H2N

SNH

OO ON

CH3

H2N SO2NH N

N

OCH3H3CO

H2N SO2NH N

N

OCH3

OCH3

H2N SO2NH

N

N

S

N

CH3

CH3

O

H

COONa

OO


S8045 S-Sulforaphane (See pages 7-8 for more information) 5 mg(+)1-Isothiocyanato-4S-(methylsulfinyl)-butane, D-sulforaphane 10 mgC6H11NOS2 FW 177.29 b.p. 125-1350C (0.01 mm)

S8046 R-Sulforaphane (See pages 7-8 for more information) 10 mg(-)1-Isothiocyanato-4R-(methylsulfinyl)-butane, L-sulforaphane 25 mgC6H11NOS2 FW 177.29 [142825-10-3] 50 mg[a]22

D -73.1 +/-0/40 (c=1, CHCl3) b.p. 125-1350C (0.01mm)Chiral natural product from broccoli. Inducer of phase II enzymes.Zhang Y, Talalay P, Cho C-G, Posner GH. Proc Natl Acad Sci USA. 89:2399-2403 (1992).

S8049 S-Sulforaphene 10 mg(-)4-Isothiocyanato-4S-(methylsulfinyl)-1-butene, L-sulforaphene 25 mgC6H9NOS2 FW 175.27 [592-95-0] [a]D-99.60 50 mgChiral natural product from radish.

S8145 Sulindac (See page 18 for more information) 5 gC20H17FO3S FW 356.42 [38194-50-2] 25 gNon-steroidal anti-inflammatory agent. Has undergone clinical trials as a chemopreventive.Kelloff GJ, Boone CW, Crowell JA et al. Cancer Epidemiol, Biomarkers Prev. 3:85-98 (1994).

S8147 Sulindac sulfide (See page 18 for more information) 25 mgC20H17FO2S FW 340.42 [32004-67-4] 100 mgAn active metabolite of Sulindac. Inhibits cyclooxygenase, but induces 500 mg apoptosis by a cyclooxygenase-independent mechanism.Meade EA, Smith WL, DeWitt DL. J Biol Chem. 268:6610-6614 (1993).

Piazza GA, Rahm AL, Krutzsch et al. Cancer Res. 55:3110-3116 (1995).

S8146 Sulindac sulfone (See page 18 for more information) 50 mgC20H17FO4S FW 372.41 [59864-04-9] 250 mgA metabolite of Sulindac, found to inhibit rat colon and mammary 500 mgcarcinogenesis without reducing prostaglandin levels.Piazza GA, Alberts DS, Hixson LJ et al. Cancer Res. 57:2909-2915 (1997).

Thompson HJ, Jiang C, Lu J et al. Cancer Res. 57:267-271 (1997).

S8151 Sumatriptan Succinate 100 mgC14H21N3O2S.C4H6O4 FW 372.4 [103628-48-4] 250 mgAntimigrane. 1 g

S8253 Sunitinib Malate (See page 29 for more information) 25 mgSutent 100 mgC26H33FN4O7 FW 532.56 [341031-54-7]Inhibitor of VEGF and PDGF tyrosine kinase.Sosman JA, Puzanov I, Atkins MB Clin. Cancer Res. 13:764s-769s (2007).

S8169 Suramin hexasodium salt 50 mgC51H34N6O23S6Na6 FW 1429.19 [129-46-4] 250 mgAn antitumor and antiparasitic compound. Uncouples G-proteins from receptors.

A potent inhibitor of melanoma heparanase and tumor cell metastasis.

Huang RR, Dehaven RN, Cheung AH et al. Mol Pharmacol. 37:304-310 (1990).

Nakajima M, DeChavigny A, Johnson CE et al. J BiolChem. 266:9661-9666 (1991).

Na+ -

O3S

Na+ -O3S

SO3-Na

+

NH C

O

NH

CH3

CO

NH

O

SO3-

Na+

SO3- Na

+

Na+-

O3S

NHC

O

NH

H3C

C O

NH

CH2CO2H

F

H

S

OCH3

O

CH3

H3CS

F

CH2CO2H

H

CH3

S

NH

H3C

O O

HN

N

CH3

CH3

N C S

S

H3C

O

N C S

S

H3C

O

N C S

S

H3C

O

HN

O

F

HN

CH3

CH3

O

NH

N CH3

CH3

OH O

OH

OH

O

CH3

CH2COOH

F

H

S

O

H3C


S8098 SU-1498 5 mgC25H30N2O2 FW 390.5 25 mgInhibits the VEGF receptor tyrosine kinase. Inhibits vascular permeability and

angiogenesis in cellular and animal models. Cell permeable.

Buguslawski G, McGlynn PW, Harvey KA, et al. J. Biolog. Chem. 279:5716-5724 (2004).

S9753 Synephrine 1 g1-[4-Hydroxyphenyl]-2-[methyl-amino]ethanol 5 gC9H13NO2 FW 167.21 [94-07-5] 10 gA biogenic amine present in herbal products and citrus juices. It has antidepressant-like effects by stimulating a1-adrenoceptors in mice.

Hurlbut JA, Carr JR, Singleton ER et al. J Aoac Int. 81:1121-1127 (1998).

Cancalon PF. J Aoac Int. 82:95-106 (1999).

Song DK, Suh HW, Jung JS et al. Neurosci Lett. 214:107-110 (1996).

Brown CM, McGrath JC, Midgley JM. Br J Pharmacol. 3:417-429 (1988).

S9754 Syntide 2 1 mgC68H122N20O18 FW 1507.85 [108334-68-5] 2 mgA synthetic substrate for Ca2+ calmodulin-dependent protein kinase II 5 mgColavizza M, Hervagault JF. Biochimie. 84: 605-10 (2002).

S9775 Systemin 0.5 mgC85H144N26O28S FW 2010.32 [137181-56-7] 1 mgA polypeptide induces the expression of proteinase inhibitor gene in (tomato). 2.5 mgWasternack C, Stenzel I and Hause B et. al. J Plant Physiol. 163: 297-306 (2006).

T0003 T2 Tetraol 1 mgC15H22O6 FW 298.33 [34114-99-3] 5 mgA type A trichothecene mycotoxin.

T0002 T2 Toxin 1 mgInsariotoxin, T2 Trichothecene 5 mgC24H34O9 FW 466.52 [21259-20-1] 10 mgA potent trichothecene group mycotoxin. It elicits a severe inflammatory

reaction in animals and has teratogenic effects.Rocha O, Anasari K, Doohan FM Food Addit. Contam. 22:369-78 (2005).

T0004 T2 Triol 1 mgC20H30O7 FW 382.45 [97373-21-2] 5 mgA type A trichothecene mycotoxin, and a T-2 toxin derivative.

T0008 Tacrolimus 1 mgFK506 5 mgC44H69NO12 FW 804.02 [104987-11-3] 25 mgAn immunosuppressant commonly used in transplant operations to prevent graft-versus-host disease.

Sawada S, Suzuki G, Kawase Y et al. J Immunol. 139:1797-1803 (1987).

T0249 Tamibarotene 10 mgC22H25NO3 FW 351.44 [94497-51-5] 50 mgAn orally active, synthetic retinoid, developed to overcome all-trans retinoic acid

(ATRA) resistance, with potential antineoplastic activity.

Tamibarotene: AM 80, retinobenzoic acid, Tamibaro. Drugs in R&D 5 (6): 359–62. 2004.

N

O

O

O

O

H3C

O

CH3

OH

O

OH

H3C

OCH3

H3C

H3C

OCH3

H3CO

HO

CH2

HN

CH3

HO

OH

H-Pro-Leu-Ala-Arg-Thr-Leu-

Ser-Val-Ala-Gly-Leu-Pro-Gly-

Lys-Lys-OH

H-Ala-Val-Gln-Ser-Lys-Pro-

Pro-Ser-Lys-Arg-Asp-Pro-

Pro-Lys-Met-Gln-Thr-Asp-OH

CH3

O

O CH3

CH3

O

HO

O

O

CH3

O

CH3 O

O CH3

O

HO

H

HO

H

OH

O

OH

NH

O

O

OH

O

OO

H

OH

OHHO

O

H

NH

O

CNHO


T0250 Tamoxifen Citrate (See page 10 for more information) 500 mgC26H29NO.C6H8O7 FW 563.6 [54965-24-1] 1 gAntiestrogenic compound. It inhibits carcinogenesis and induces apoptosis in 5 gcancer cell lines.Ueo H, Matsuoka H, Honda M et al. Cancer Lett. 71:19-24 (1993).

Moon RC, Kelloff GJ, Detrisac CJ et al. Anticancer Res. 12:1147-53 (1992).

Cadieux, R. Post Graduate Medicine. 106:6 (1999).

T0251 Tamsulosin Hydrochloride 10 mgC20H28N2O5S.HCl FW 444.98 m.p. 280-2900 [106463-17-6] 25 mgAn a1-adrenoceptor antagonist used to treat benign prostatic hypertrophy. 100 mgTakenaka T, Fujikura T, Honda K et al. Yakugaku Zasshi. 115:773-89 (1995).

T0152 Tandutinib 1 mgC31H42N6O4 FW 562.70 [387867-13-2] 5 mgA piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic 25 mg activity. Tandutinib inhibits the autophosphorylation of FLT3 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases,

thereby inhibiting cellular proliferation and inducing apoptosis.Brownlow, N. Leukemia (2008), 22(7), 1452-1453.

DeAngelo, D. Blood (2006), 108(12), 3674-3681.

T0153 Tanshinone I 10 mgC18H12O3 FW 276.29 [568-73-0] 25 mgTanshinones are pigments isolated from the herbal medicine Salvia miltiorrhiza 100 mgBUNGE. Tanshinone I was found to have cytotoxicity against human macrophages and IFN-g production in KLH-primed lymph node cells.Li ZT, Yang BJ, Ma GE. Acta Pharm Sinica. 26:209-213 (1991).

Ryu SY, Lee CO, Choi SU, Planta Medica. 63:339-342 (1997).

Kang BY, Chung SW, Kim SH et. al. Immunopharm. 49:355-361 (2000).

T0154 Tanshinone IIA 10 mgC19H18O3 FW 294.34 [568-72-9] m.p. 198-2000C 25 mgTanshinone IIA is one of the active ingredients isolated from the roots of the 100 mg Chinese medicinal plant, Salvia miltiorrhiza B. Tanshinones are cytoxic to various

human cancer cell lines. Dihydrotanshinones and others have anti-allergic activity in in vitro studies.

Sato M, Sato T, Ose Y et al. Mutat Res. 265:149-154 (1992).

Wu WL, Chang WL, Chen CF. Am J Chin Med. 19:207-216 (1991).

Ryu SY, Lee CO, Choi SU. Planta Med. 63:339-342 (1997).

Ryu SY. Oak MH, Kim KM. Planta Med. 65:654-655 (1999).

T0076 TAT 0.5 mgC64H119N33O13 FW 1558.88 1 mgA transcriptional transactivator protein essetial for HIV-1 viral replication. 2.5 mg It also stimulates the transcription of intergratded provirus.Liou L, Herrmann CH, Rice AP. J Virol. 76: 10579-10587 (2002).

T0077 TAT 2-4 0.5 mgC132H240N66O29 FW 3215.81 1 mg

2.5 mg

T0081 Taurine 50 g2-Aminoethanesulfonic acid 100 gC2H7NO3S FW 125.15 m.p. 3000C [107-35-7]Inhibits diethylnitrosamine and phenobarbital-induced heptocarcinogenesis.Okamoto, K., Sugie, S., Ohnishi, M et al. Jpn J Cancer Res. 87:30-36 (1996).

CH3CH2C C OCH2CH2NCH3

CH3

.C6H8O7

SH2N

O O

H3COCH3

HN

O

OH3CHCl

O

H3C CH3

O

OCH3

H2N

S

O

O

OH

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-

Gln-Arg-Arg-Arg-Gly-Tyr-Gly-

Arg-Lys-Lys-Arg-Arg-Gln-Arg-

Arg-Arg-Gly-OH

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-

Gln-Arg-Arg-Arg-NH2

N N

N

N

O

HN

OOMe

ON

O

O

O


Taxanes: (Taxol (See Paclitaxel)

T0093 2'-Acetyltaxol 5 mgC49H53O15 FW 895.95 [92950-40-8] 10 mg

25 mg

T0094 2',7-bis Acetyltaxol 5 mgC51H55NO16 FW 938.0 10 mg

25 mg

T0109 13-Acetyl-9-Dihydrobaccatin-III 5 mgC33H44O12 FW 630.68 [142203-65-4] 10 mg

25 mg

T0092 1-Hydroxy Baccatin I 5 mgC32H44O13 FW 636.88 10 mg

25 mg

T0095 Baccatin III 5 mgC31H39O11 FW 586.63 [27548-93-2] 10 mg

25 mg

T0117 Benzyl Analog of Taxol 1 mgC48H53NO14 FW 867.93 5 mg

T0096 Cephalomannine 5 mgC45H53NO14 FW 831.91 [71610-00-9] 10 mg

25 mg

T0118 7-epi-Cephalomannine 5 mgC45H53NO14 FW 831.9 10 mg

25 mg

T0099 10-Deacetylbaccatin-III 5 mgC29H36NO10 FW 544.59 [32981-86-5] 10 mg

25 mg

T0100 10-Deacetyl taxol 5 mgC45H49NO13 FW 811.87 [78432-77-6] 10 mg

25 mg

O

OH

O CH3

O

H

OH

OO

O

O

O

NH

O OCH3

O

O

O

CCH3

O

O CH3

O

H

OH

OO

O

O

O

NH

O OCH3

O

OO

CCH3

O

CCH3

O

OH

O

OH

OH

O

O

O

O

O O

O

O

OHO

OAc OAc

AcO OAcH

Ac

AcO

O

OH

O CH3

O

H

OH

OO

HO

OCH3

O

O

O

OH

O CH3

O

HOH

OO

O

O

OH

NH

O OH3C

O

O

O

OH

O CH3

O

H

OH

OO

O

O

OH

NH

O OCH3

O

O

O

OH

O CH3

O

H

OH

OO

O

O

OH

NH

O OCH3

O

O

O

OH

O CH3

O

H

OH

OO

HO

HO O

O

OH

O CH3

O

H

OH

OO

O

O

OH

NH

O HO O


T0101 7-epi-10-Deacetyltaxol 5 mgC45H49NO13 FW 811.87 [78454-17-8] 10 mg

25 mg

T0097 10-Deacetyltaxol-B (10-Deacetylcephalomannine) 5 mgC43H51NO13 FW 789.86 10 mg

25 mg

T0098 10-Deacetyltaxol-C 5 mgC44H55NO13 FW 805.91 10 mg

25 mg

T0108 10-Deacetyl-7-xylosyltaxol, 90% 5 mgC51H60NO17 FW 959.02 10 mg

25 mg

T0116 2",3"-Dihydrocephalomannine 5 mgC45H55NO14 FW 833.92 10 mg

25 mg

T0102 7-epi-Taxol 5 mgC47H51NO14 FW 853.91 [105454-04-4] 10 mg

25 mg

T0115 Taxol side chain acid 5 mgC16H15NO4 FW 285.29 10 mg

25 mg

T0103 Taxol-side chain diol 5 mgC16H17NO3 FW 271.34 10 mg

25 mg

T0104 Taxol-side chain methyl ester 5 mgC17H18NO4 FW 299.32 10 mg

25 mg

T0119 Taxol-side chain β-lactam 5 mg(3R,4S) -3-(acetyloxy)-2-oxo-4-phenyl-1-azetidinecarboxylic acid 10 mg1,1-dimethylethyl ester 25 mgC16H19NO5 FW 305.33 [161183-22-8]Intermediate for the semi-synthesis of various taxanes.

OH

NH

OH

O

O

O

OH

O CH3

O

H

OH

OO

O

O

OH

NH

O OCH3

O

O

O

OH

O CH3

O

H

OH

OO

O

O

OH

NH

O OCH3

O

O

O

O CH3

O

HOH

OO

O

O

OH

NH

OHO

OOO

HO

OH

OH

O

OH

O CH3

O

H

OH

OO

O

O

OH

NH

O HO O

O

OH

O CH3

O

H

OH

OO

O

O

OH

NH

OHO

O

NH

OCH3

OO

OH

NH

OCH3

OO

OH

N

AcO O

O

O

O

OH

O CH3

O

HOH

OO

O

O

OH

NH

O HO O


T0105 Taxol C 5 mgC47H57NO14 FW 859.95 [153415-45-3] 10 mg

25 mg

T0090 7-(triethylsilyl)-Baccatin III 5 mgC37H52O11Si FW 700.89 10 mgIntermediate for the semi-synthesis of various taxanes. 25 mg

T0091 7-(triethylsilyl)-10-deacetyl Baccatin III 5 mgC35H50O10Si FW 658.85 10 mgIntermediate for the semi-synthesis of various taxanes. 25 mg

T0106 Xylosyltaxol, 90% 5 mgFW 980.10 10 mg

25 mg

T0107 Xylosyltaxol C, 90% 5 mgFW 980.10 10 mg

25 mg

T0110 Taxanes Standards Mixture 500 µlA mixture of 13 different taxanes at a concentration of 50 µg/ml in

methanol and 0.1% acetic acid.

10-deacetylbaccatin III, Baccatin III, 10 deacetyl-7-xylosyltaxol B, Taxinine M,

10 deacetyl 7 zylosyltaxol, 10 deacetyl 7 xylosyltaxol C, 10 deaceytltaxol,

7-Xylosyltaxol, Cephalomannine, 10-deacetyl-7-epitaxol, Paclitaxel,

Taxol C, 7-epi taxol.

T0114 Taxinine M 5 mgC35H42O14 FW 686.70 10 mg

25 mg

T0298 Tazobactam 100 mgFree acid 500 mgC10H12N4O5S FW 300.29 [89786-04-9] 1 gA beta-lactamase inhibitor antibacterial.Bryson HM, Brogden RN. Drugs. 47:506-35 (1994).

HO OSi(CH2CH3)3

O

OH

HO

O

O

HO

O

CH3

O

N

N

N

N

O

H

COOH

CH3

S

OO

OSi(CH2CH3)3

O

OHHO

O

O

HO

O

CH3

O

OO

H3C

OAc

HH

O

CH3

O

OH3C

O

AcOO

O

O

OOH

HO

O

O CH3

O

HOH

OO

O

O

OH

NHC6H11

O OH3C

O

OOO

HO

OH

OH

O

O CH3

O

HOH

OO

O

O

OH

NH

O OH3C

O

OOO

HO

OH

OH

O

OH

O CH3

O

HOH

OO

O

O

OH

NHC6H11

O OH3C

O

O


T0299 Tazobactam sodium 100 mgC10H11N4NaO5S FW 322.274 [89785-84-2] 500 mgA beta-lactamase inhibitor antibacterial. 1 gBryson HM, Brogden RN. Drugs. 47:506-35 (1994).

T1298 TDZD-8 5 mgC10H10N2O2S FW 222.26 [327036-89-5] 25 mgAn inhibitor of glycogen synthase kinase-3 (GSK3) beta, which was found to be a key intermediate

in apoptotic signaling associated with neurodegenerative diseases such as Parkinsons'.Chen G, Bower KA, Ma C et al. FASEB J. 18:1162-1164 (2004).

Barry FA, Graham GJ, Fry MJ et al. FEBS letters. 553:173-178 (2003).

T1605 Tebuconazole (See page 16 for more information) 5 gC16H22ClNO3O FW 307.82 [107534-96-3] 10 gIs a triazole fungicide used agriculturally to treat plant pathogenic fungi. It is 100 glisted as a potential carcinogen by the EPA.

Zhang, S. Faming Zhuanli Shenqing Gongkai Shuomingshu (2008),

Tegafur (See Ftorafur)

T1733 Teicoplanin 100 mgC78H77Cl2N9O31 FW 1707.39 [61036-62-2] 250 mgIs an antibiotic used to treat serious infections caused by Gram-positive bacteria. 1 gBabul N, Pasko M. Drug Intell Clin Pharm. 22: 218-226 (1988).

Campoli-Richards DM, et al. Drugs. 40: 449-486 (1990).

T1844 Telbivudine 100 mgC10H14N2O5 FW 242.23 [3424-98-4] 250 mgA nucleoside analogue used in the treatment of hepatitis B infection as a specific 1 ginhibitor for virus replication. Antiviral.

Han, S.-H.B., et al.: Expert Opin. Invest. Drugs, 14, 511 (2005)

T1644 Telmisartan 50 mgC33H30N4O2 FW 514.62 [144701-48-4] 100mgA nonpeptide angiotensin II receptor antagonist which inhibits the 500 mgangiotensin II AT1 receptor.

McClellan KJ, Markham A. Drugs. 56:1039-44 (1998).

T1750 Temocapril Hydrochloride (See page 25 for more info) 10 mgC23H28N2O5S2

.HCl FW 513.07 [110221-44-8] 25 mgIs an ACE inhibitor (angiotensin converting enzyme). Pro-drug that is converted 100 mgin vivo to treat hypertension.

Shionoiri, H. Cardiac Practice (1995), 6(4), 487-94.

T1849 Temozolomide 25 mgC6H6N6O2 FW 194.15 [85622-93-1] 100 mgAn alkylating antitumor agent that has antiangiogenic activity 500 mgand induces apoptosis in cell cultures.

Tisdale MJ. Biochem Pharmacol. 36:457-62 (1987).

Kurzen H, Schmitt S, Naher H, Mohler T. Anticancer Drugs. 14:515-22 (2003).

Gunther W, Pawlak E, Damasceno R et al. Br J Cancer. 88:463-9 (2003).

N

NN

N

N

NH2

O

O

CH3

NN

SO

H3C

O

N

N N

N

COOH

CH3

CH3

CH3

N

S

O

H OO

O

OH

CH3

N

N

N

Na

O OH3C

NH

S

NO OH

O

S

HCl

Cl

HO CH3

H3C CH3

N

N

N

O

HO O

HO

NH

HO

O O

OO

O

RN

OHHO

OH

Cl

NH

O

HN

O

HO O

HO

HO

OH

OH

O

HN

O

NH

O

NH OHN O

OHO

HO

NH2

OH

HO

Cl

N

NH

O

O

O

HO

OH


T1754 Tenatoprazole 100 mgC16H18N4O3S FW 346.41 [113712-98-4] 500 mgA proton pump inhibitor. 1 g Nakamura T, Nippon Rinsho. 60 Suppl. 2:650-4 (2002).

T1652 Teniposide 25 mgC32H32O13S FW 656.67 [29767-20-2] 100 mgA derivative of the cytotoxic natural product, epipodophyllotoxin, acts on 500 mgtopoisomerase II that results in DNA strand breaks.

Ross W, Rowe T, Glisson B, Yalowich J, Liu L. Cancer Res. 44:5857-60 (1984).

T1854 Tenofovir Monohydrate 100 mgC9H14N5O4P.H2O FW 305.23 [206184-49-8] 250 mgAn antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors 1 g(nRTIs), which block reverse transcriptase, an enzyme crucial to viral production

in HIV-infected people.

Cihlar, T., et al. Antiviral Res. 54: 37-45 (2002).

T1855 Tentoxin 1 mgC22H30N4O4 FW 414.50 [28540-82-1] 5 mgCyclic peptide from fungus Alternaria.

He F, Samra HS, Johnson EA, Degner NR, McCarty RE, Richter ML. Biochemistry. 2008 Jan 15;47(2):836-44.

T1654 Tenoxicam 250 mgC13H11N3O4S2 FW 337.38 [59804-37-4] 1 gNonsteroidal anti-inflammmatory, analgesic agent.Found to have antitumor effects. 5 gGiordano V, Giordano M, Knackfuss IG et al. Injury 34:85-94 (2003).

Sakusabe N, Okada K, Sato K et al. Jpn J Cancer Res. 90:1146-51 (1999).

T1952 Tenuazonic acid 1 mgC10H15NO3 FW 197.23 [610-88-8] 5 mgA metabolite found in a strain of the fungus Alternaria tenuis Auct. which functions

as an antibiotic with antiviral and antineoplastic properties, and may also act as a mycotoxin.

Chen, S., et al. Biochim. Biophys. Acta. 1767: 306-318 (2007).

T1670 Terazosin Hydrochloride dihydrate 50 mgC19H25N5O4

.HCl.2H2O FW 423.93 [70024-40-7] 250 mgAn a1-selective blocker. Its inhibitory effect on prostate tumor growth may be 1 gthe result of antiangiogenic activity.

Kyncl JJ. J Clin Pharmacol. 33:878-83 (1993).

Pan SL, Guh JH, Huang YW et al. J Urol. 169:724-9 (2003).

T1672 Terbinafine Hydrochloride 1 gC21H25N.HCl FW 327.90 [78628-80-5] 5 gAn antimicrobial agent. It was recently found to have anticancer 10 gproperties in human cancer cell lines.Lee WS. Chen RJ. Wang YJ et al Int J Cancer. 106:125-37 (2003).

Petranyi G, Ryder NS, Stutz A. Science. 224:1239-41 (1984).

T1674 Terbutaline 1 gC12H19NO3 FW 225.28 [23031-25-6] 5 gA beta-adrenoceptor agonist used to treat asthma and premature labor.

Aldridge JE, Meyer A, Seidler FJ, Slotkin TA. Toxicol Appl Pharmacol. 203:132-44 (2005).

HO

OH

HN

C(CH3)3

OH

N

CH3

CH3

H3C

CH3

HCl

NS

S

HN

CH3

NOOH

OO

S

O

OO

OO

O

HOOH

O

H3CO

OH

OCH3

O

N

NO

O

NH2

N

N

O

O

H2OHCl2

N

N N

N

NH2

O P

OOH

OH

H2O

N

OHN

O

NON

HO

HN

O

HO

O

N N

NH

SH3CON

H3C OCH3

CH3

O


T1675 Teriparatide Acetate Please inquireC181H291N55O51S2 FW 4117.72 [52232-67-4]A synthetic peptide that consists the 1-34 amino acid fragment of human parathyroid hormone. It stimulates new bone formation, repairs structural defects and reduces risks of fractures in postmenauposal women with severe osteoporosis. Yodfat Y. Harefuah. 146:134-9, 164 (2007).

T1673 Terlipressin Acetate 1 mgC52H74N16O15S2 FW 1227.37 [14636-12-5] 5 mgIn humans, the anabolic effects of teriparatide are manifest as an increase in skeletal mass,

an increase in markers of bone formation and resorption, and an increase in bone strength.

T1677 Tetracycline 10 gC22H24N2O8 FW 444.43 [60-54-8] 25 gIt is used in the treatment of chronic inflammatory cells. Tetracycline derivatives 100 g induce apoptosis in osteoclasts, Jurkat T lymphocyte cells and in cultured monocytes and macrophages.Bettany JT, Peet NM, Wolowacz RG et al. Bone. 27:75-80 (2000).

Liu J, Kuszynski CA, Baxter BT. Biochem Biophys Res Commun. 260:562-7 (1999).

Bettany JT, Wolowacz RG. Adv dent Res. 12: 136-43 (1998).

T1679 Tetracycline Hydrochloride 1 gC22H24N2O8

.HCl FW 480.90 [64-75-5] 5 gAntimicrobial agent. Tetracycline-controlled antisense bcl-2 expression induce 25 g apoptosis in human neuroblastoma cell line SK-N_MC.Atrasheuskaya AV, Fredeking TM, Ignatyev GM. Clin Exp Immunol. 131:148-154 (2003).

Guan J, Chen J, Zhao H. Zhonghua Bing Li Xue Za Zhi. 31:135-139 (2002).

T1776 D-Tetrahydropalmatine 25 mgC21H25NO4 FW 355.43 100 mgInhibits dopamine and serotonin uptake of synaptosomes in the rat brain by blocking 500 mgdopaminergic neurons.

T1676 L-Tetrahydropalmatine 100 mgC21H25NO4 FW 355.43 [483-14-7] 500 mgAn alkaloid found in the plants of the Carydalis species. It depletes neurotransmitters

such as dopamine, noradrenaline and serotonin.

Liu GQ, Algeri S, Garattini S. Arch Int Pharmacodyn Ther. 258:39-50 (1982).

Lin MT, Chueh FY, Hsieh MT, Chen CF. Clin Exp Pharmacol Physiol. 23:738-42 (1996).

T1678 D,L-Tetrahydropalmatine 100 mgC21H25NO4 FW 355.43 [10097-84-4] 500 mgAn alkaloid found in the plants of the Carydalis species. It depletes neurotransmitters such as dopamine, noradrenaline and serotonin.

Liu GQ, Algeri S, Garattini S. Arch Int Pharmacodyn Ther. 258:39-50 (1982).

Lin MT, Chueh FY, Hsieh MT, Chen CF. Clin Exp Pharmacol Physiol. 23:738-42 (1996).

T1777 Tetrandrine 100 mgC38H42N2O6 FW 622.75 [518-34-3] 500 mgA bisbenzylisoquinoline alkaloid, purified from chinese medicinal herb. It acts as 1 g an immuno suppressant and a Ca+2 channel blocker. Tetrandrine also induces apoptotic cell death in human leukemic U397 and human leukemic HL-60 cells.

Lai YL, Chen YJ, Wu TY et al. Anticancer Drugs. 9:77-81 (1998).

Dong Y, Yang MM, Kwan CY. Life Sci. 60:135-40 (1997).

Ser-Val-Ser-Glu-Ile-Gln-Leu-

Met-His-Asn-Leu-Gly-Lys-His-

Leu-Asn-Ser-Met-Glu-Arg-Val-

Glu-Trp-Leu-Arg-Lys-Lys-Leu-

Gln-Asp-Val-His-Asn-Phe-OH

Gly-Gly-Gly-c[Cys-Tyr-Phe-Gln-

Asn-Cys]-Pro-Lys-Gly-NH2

OH O OH O

OH

CONH2

HO CH3 HN(CH3)2

OH

.HCl

OH O OH O

OH

CONH2

HO CH3 HN(CH3)2

OH

NO

O

O

O

H

NO

O

O

O

N

H3C

OCH3

OCH3

OCH3

N

H3CO

O CH3

O

N

O

O

O

O


T2800 Thalidomide 100 mgC13H10N2O4 FW 258.23 [50-35-1] 250 mgHighly teratogenic compound associated with fetal abnormalities. Recently 500 mg found to have antiangiogenic and antitumor activities.Fratta ID et al. Toxicol Appl Pharmacol 7:268 (1965).

D'Amato J, Loughnan MS, Flynn E, Folkman J. Proc Natl Acad Sci USA. 91:4082-5 (1994).

Eisen T, Boshoff C, Mak I et al. Br J Cancer. 82:812-7 (2000).

T2801 Thapsigargin 1 mgC34H50O12 FW 650.75 [67526-95-8] 5 mgA cell permeable intracellular calcium releaser and tumor promoter.

Hakii H, Fujiki H, Suganuma M et al. J. Cancer Res. Clin. Oncol 111:177-181 (1986).

Takemura H, Hughes AR, Thastrup O, Putney JW. J. Biol. Chem. 264:12266-12271 (1989).

T2816 L-Theanine 1 gN g-Ethyl L-glutamine, L-glutamic acid g-(ethylamide) 5 gC7H14N2O3 FW 174.19 [3081-61-6] 25 gOne of the components of green tea. It was found to decrease the blood pressure of spontaneously hypertensive rats. It modulates the activity of several antitumor drugs.Yokogoshi, H, Kat Y, Sagesaka YM et al. Biosci Biotech Biochem. 59:615-618 (1995).

Sugiyama T, Sadzuka Y, Nagasawa K et al. J Cancer Res. 90:775-780 (1999).

T2817 Theophylline 100 gC7H8N4O2 FW 180.16 [58-55-9] 250 gAn inhibitor of cyclic phosphodiesterase. Found to decrease incidence and multiplicity of tumors in the brain, spinal cord, peripheral nerves, and kidneys.Alexandrov VA, Bespalov VG, Petrov AS et al. Carcinogenesis. 17:1935-1939 (1996).

T2930 Thiabendazole 10 gC10H7N3S FW 201.25 [148-79-8] 100 gA widely used fungicide and antihelminthal agent. Mediates Cytochrome 500 g P450 1A1 induction.Ogunsusi RA. Res Vet Sci. 25:251-252 (1978).

lemaire G, Delescluse C, Pralavorio M et al. Life Sci. 74:2265-2278 (2004).

Thiamazole (See Methimazole)

T2932 Thiamphenicol Glycinate HCl 1 gC14H18Cl2N2O6S.HCl FW 449.70 [2611-61-2] 5 gUsed in the treatment of respiratory infections. 25 gFerrari V. Sex Transm Dis. 11:336-9 (1984).

T2934 Thiamphenicol Palmitate 5 gC28H45Cl2NO6S FW 594.63 [52628-58-7] 25 gNon-carcinogenic synthetic ester of thiamphenicol.

Della Bella D, Veronese M, Marca G, Franceschinis R. Arzneimittelforschung. 24:836-9 (1974).

T2935 Thiamphenicol 1 gC12H15Cl2NO5S FW 356.22 [15318-45-3] 5 gThiamphenicol is used as an antibacterial reagent. 25 gO'Neil, M. (ed.) The Merck Index, 13th Ed. Merck & Co, Inc. Whitehouse Station, NJ 2001.

CH3N

NO

O

N

H

N

CH3

N

NH

O

O

O

O

SO2CH3

CH

CH2 O C(CH2)14CH3

O

OH

HCHN C C

HCl

ClO

SO2CH3

CH

CH2 O O CH2

CHOH

CH2OH

OH

H2CHN C C

HCl

ClO

. HCl

N

HN

S

N

NH

OH

O O

NH2

H2CH3C

O

OH O

OH

O

OH

OO

OO

O

O

SO

O

OH

NH

HO

O

Cl Cl


T2528 S-(N-Thienylmethylthiocarbamoyl)-L-cysteine 10 mgC9H12N2O2S3 FW 276.40 25 mgA cysteine conjugate of thienyl isothiocyanate. 100 mg

T3031 Thienylbutyl Isothiocyanate 25 mgC9H11NS2 FW 197.32 50 mg(See page 18 for more information) 100 mgA bifunctional inhibitor of lung and colon carcinogenesis. 500 mgLam LKT, Kenney P, Bergstrom CP, Lam SH. Proc. Am. Assoc. Cancer Res. 40: 57 (1999).

T3032 Thienyldecyl Isothiocyanate 25 mgC15H23NS2 FW 281.48 50 mg(See page 18 for more information) 100 mgAn analog of thienylbutyl isothiocyanate. 500 mg

T3033 Thienyldodecyl Isothiocyanate 25 mgC17H27NS2 FW 309.54 50 mg(See page 18 for more information) 100 mgAn analog of thienylbutyl isothiocyanate. 500 mg

T3034 Thienylethyl Isothiocyanate 25 mgC7H7NS2 FW 169.27 50 mg(See page 18 for more information) 100 mgAn analog of thienylbutyl isothiocyanate. 500 mg

T3035 Thienylheptyl Isothiocyanate 10 mgC12H17NS2 FW 239.40 25 mg(See page 18 for more information) 50 mgAn analog of thienylbutyl isothiocyanate. 100 mg

T3036 Thienylhexyl Isothiocyanate 25 mgC11H15NS2 FW 225.38 50 mg(See page 21 for more information) 100 mgAn analog of thienylbutyl isothiocyanate. 500 mg

T3037 Thienylmethyl Isothiocyanate 100 mgC6H5NS2 FW 155.24 500 mg(See page 18 for more information) 1 gAn analog of thienylbutyl isothiocyanate.

T3038 Thienylnonanyl Isothiocyanate 25 mgC14H21NS2 FW 267.46 50 mg(See page 18 for more information) 100 mgAn analog of thienylbutyl isothiocyanate. 500 mg

S (CH2)4NCS

S (CH2)10NCS

S (CH2)12NCS

S (CH2)2NCS

S (CH2)7NCS

S (CH2)6NCS

S CH2NCS

S (CH2)9NCS

NH2

S

O

OHNH

S

S


T3039 Thienyloctyl Isothiocyanate 25 mgC13H19NS2 FW 253.43 50 mg(See page 18 for more information) 100 mgAn analog of thienylbutyl isothiocyanate. 500 mg

T3040 Thienylpentyl Isothiocyanate 25 mgC10H13NS2 FW 211.35 50 mg(See page 18 for more information) 100 mgAn analog of thienylbutyl isothiocyanate. 500 mg

T3041 Thienylpropyl Isothiocyanate 25 mgC8H9NS2 FW 183.30 50 mg(See page 18 for more information) 100 mgAn analog of thienylbutyl isothiocyanate. 500 mg

T3133 Thioctic Acid 5 gC8H14O2S2 FW 206.33 [1077-28-7] 10 gGrowth factor for bacteria; prosthetic group, coenzyme or substrate in plants and 25 ganimals. Occurs naturally in the (d) conformation. It has antioxidant and neuroprotecitve effects.Packer L, Tritschler HJ, Wessel K. Free Radic Biol Med. 22:359-78 (1997).

T2833 1-Thio-β-D-glucose tetraacetate 250 mgC14H20O9S FW 364.4 [19879-84-6] 1 g

T2835 6-Thioguanine (See page 30 for more information) 250 mgC5H5N5S Mol. Wt: 167.19 [154-42-7] 500 mgA chemotherapy drug that demonstrates anti-neoplastic, immunosuppressive 1 gand anti-cancer activities. 6-Thioguanine is often used to treat inflammatory diseases and leukemia.Karran P. Br Med Bull 79-80: 153-70 (2006).

Sartorelli AC, Booth BA. Cancer Res. 25: 1393-40 (1965).

T2834 Thiolutin 1 mgC8H8N2O2S2 FW 228.29 [87-11-6] 5 mgA sulfur containing antibiotic which is a potent inhibitor of RNA polmerase. 10 mg Inhibits adhesion of human umbilical vein endothelial cells and thereby suppresses

tumor cell induced angiogenesisKebaara, B. W. Genome (2006), 49(8), 894-899.

T2936 Thioridazine Hydrochloride 5 gC21H26N2S2

.HCl FW 407.04 [130-61-0] 25 gIs a piperidine antipsychotic

Robertson A, MacDonald C Pharmacol. Biochem. Behav. 21 (1): 97–101 (1984).

T3134 Thiostrepton 1 gC72H85N19O18S5 FW 1664.89 [1393-48-2] 5 gIsolated from Streptomyces sp. It is highly active against gram-positive bacteria.

Gonzalez RL Jr, Chu S, Puglisi JD. Nucleic Acids Res. 12:2091-2097 (2007).

García-Marcos A, Morreale A, Guarinos E, et al. Nucleic Acids Res. 35:7109-7117 (2007).

Jonker HR, Ilin S, Grimm SK, et al. Nucleic Acids Res. 35:441-454 (2007).

N

NNH

N

SH

H2N

S (CH2)8NCS

S (CH2)5NCS

S (CH2)3NCS

S S

COOH

H

O

OAc

OAc

AcO

SH

AcO

SS

N

H3C

O

HN

O

CH3

S

N

N

S

HCl

NH

OHN O

ONH

O

N

OH

OH

O

O

N

S

N

HN

NHO

NH

N

S

S

NO

NH

HN

S

N

O

OHN

HO OH

NH

O

NH2

O

HN O

N

S

HO


T2933 4-Thiouridine 5 mgC9H12N2O5S FW 260.27 m.p. 141-1430C [13957-31-8] 25 mgThionucleobase, used as antisense agent. 100 mgTesta SM, Disney MD, Turner DH, Kierzek R. Biochemistry 38:16655-62 (1999). 250 mg

T2970 Thrombin Receptor Agonist 1 mgC81H118N20O23 FW 1739.96 [137339-65-2] 2 mgA synthetic peptide that mimics the effects of thrombin, activates proteaase 5 mgactivated receptor-1 in wounds of mice.Strukova SM, Dugina TN, and Chistov IV et. al.Clin Appl Thromb Hemost. 7: 325-9 (2001).

T3185 Thymidine 1 gC10H14N2O5 FW 242.23 [50-89-5] 5 gA pyrimidine deoxynucleoside, also known as deoxymythidine, or the DNA 10 gnucleoside T.

Reichard P, Estborn B. J. Biol. Chem. 188:839-846 (1951).

T3093 Thymopentin 5 mgC30H49N9O9 FW 679.8 10 mgA synthetic peptide corresponding to the 32-36 amino acid fragment of 25 mgthymopoietin. It exhibits biological fuctions like the natural hormone including T-cells differentiation and immune systems regulation.Onoue S, Liu B, Nemoto Y, Hirose M, Yajima T. Anal Sci. 22:1531-5 (2006).

T3094 Thymopentin Acetate (TP-5) 10 mgC30H49N9O9

.CH3.COOH FW 679.80 [62558-55-0] 50 mgA synthetic immunomodulating pentapeptide, found to increase the number of 1 gcells undergoing apoptosis in irradiated cells and selectively bind to apoptotic cells.Gonser S, Crompton NE, Folkers G et al. Mutat Res. 558:19-26 (2004).Gonser S, Weber E, Folkers G. Pharm Acta Helv. 73:265-73 (1999).

T3096 Thymosin α-1 10 mgC129H215N33O55 FW 3108.3 [62304-98-7] 50 mgAn immunomodulating thymic peptide that has been used for the treatment of 1g chronic hepatitis B viral infection. It has been shown to activate tumor-associated

macrophages to a tumoricidal state in a murine model.

Shrivastava P, Singh SM, Singh N. J Biomed Sci. 11:623-30 (2004).Li CL, Zhang T, Saibara T et al. Int Immunopharmacol. 2:39-46 (2002).

T3097 Thymosin α-1 Acetate Please inquireC129H215N33O55 FW 3108.3 [62304-98-7]Thymosin a1 has immunoregulatory properties enhancing immune functions. For the treatment of hepatitis B and C.

T3098 Thymosin β-4 Acetate Please inquireC212H350N56O78S FW 4963.49 [77591-33-4]An actin-sequestering peptide that modulates inflammation and healing in different tissues.

It plays a major role in angiogenesis and tumor metastasis.

Moon HS, Even-Ram S, Kleinman HK, Cha HJ. Exp Cell Res. 312: 3425-31 (2006).Larsson LI, Holck S. Hum Pathol. 38: 114-9 (2007).

N

HN

O

OHOH

HOCH2

S

O

H-Ser-Phe-Leu-Leu-Arg-Asn-

Pro-Asn-Asp-Lys-Tyr-Glu-Pro-

Phe-OH

H-Arg-Lys-Asp-Val-Tyr-OH

Arg-Lys-Asp-Val-Tyr

Ac-Ser-Asp-Ala-Ala-Val-Asp-

Thr-Ser-Ser-Glu-Ile-Thr-Thr-

Lys-Asp-Leu-Lys-Glu-Lys-Lys-

Glu-Val-Val-Glu-Glu-Ala-Glu-

Asn

Ac-Ser-Asp-Ala-Ala-Val-Asp-

Thr-Ser-Ser-Glu-Ile-Thr-Thr-

Lys-Asp-Leu-Lys-Glu-Lys-Lys-

Glu-Val-Val-Glu-Glu-Ala-Glu-

Asn

Ac-Ser-Asp-Lys-Pro-Asp-Met-

Ala-Glu-Ile-Glu-Lys-Phe-Asp-

Lys-Ser-Lys-Leu-Lys-Lys-Thr-

Glu-Thr-Gln-Glu-Lys-Asn-Pro-

Leu-Pro-Ser-Lys-Glu-Thr-Ile-

Glu-Gln-Glu-Lys-Gln-Ala-Gly-

Glu-Ser-OH

HN

N

O

O

OHO

HO


T3099 Thymus Factor 1 mgC33H57N13O15 FW 875.9 2 mgA thymic peptide hormone. 5 mg

T3100 Thyrotropin-Releasing Hormone (TRH) 5 mgC16H23NO FW 363.4 10 mgThe final precursor for TRH formation. It signals through a G protein-coupled 25 mg receptor.Laakkonen L, Li W, Perlman JH, and Guarnieri F. et. al.Mol Pharmacol. 49: 1092-6 (1996).

T3197 L-Thyroxine Sodium Salt Pentahydrate 1 g

C15H10I4NNaO4.5H2O FW 888.93 [6106-07-6] 5 g

A thyroid hormone involved in controlling the rate of metabolic processes.

Udupa, A. Indian Journal of Experimental Biology (1976), 14(1), 14-18.

T3101 TRH, Free Acid 5 mgC16H21N5O5 FW 363.4 10 mg

25 mg

T3305 Tibolone 100 mgC21H28O2 FW 312.45 [5630-53-5] 500 mgA synthetic normethyl testosterone derivative used in the prevention of 1 gpostmenopausal osteoporosis. It is capable of inducing apoptosis in breast cancer cell lines.

Coope J. Br Med J. 281:456-7 (1980).

Kandouz M, Lombet A, Perrot JY et al. J Steroid Biochem Mol Biol. 69:463-71 (1999).

T3310 Ticlopidine Hydrochloride 1 gC14H14ClNS.HCl FW 300.25 [53885-35-1] 5 gA platelet aggregation inhibitor capable of inducing apoptosis in various cancer 25 g cell lines. Its effects on platelet aggregation may be the result of inhibition of VEGF.Chen WH, Yin HL, Chang YY et al. Kaohsiung J Med Sci. 13:589-97 (1997).

Ma L, Elliott SN, Cirino G et al. Proc Natl Acad Sci U S A. 98:6470-5 (2001).

T3324 Tigecycline (See page 32 for more information) 100 mgC29H39N5O8 FW 585.65 [220620-09-7] 250 mgIs a glycylcycline antibiotic. Tigecycline is bacteriostatic and is a protein synthesis 1 g inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry

of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation.

Rose W, Rybak M (2006). "Tigecycline: first of a new class of antimicrobial agents.". Pharmacotherapy 26 (8): 1099–110.

T3350 Timolol Maleate 100 mgC13H24N4S.C4H4O4 FW 432.50 [26921-17-5] 250 mgA b-adrenergic receptor selective antagonist used as a antiglaucoma agent. 1 gHall RA, Robson RD, Share NN. Arch Int Pharmacodyn Ther. 213:251-63 (1975).

Feghali JG, Kaufman PL, Radius RL et al. Acta Ophthalmol (Copenh). 66:180-6 (1988).

T3454 Tinidazole 100 gC8H13N3O4S FW 247.27 [19387-91-8] 250 gA synthetic imidazole derivative used in antiprotozoal treatment.

Sawyer PR, Brogden RN, Pinder RM et al. Drugs. 11:423-40 (1976).

H-pGlu-His-Pro-NH2

H-Gln-Ala-Lys-Ser-Gln-Gly-

Gly-Ser-Asn-OH

pGlu-His-Pro-OH

N N

S

N O NH

C(CH3)3

O

OH

N

NS CH3

NO2

CH3

OO

N

Cl S .HCl

O

H

CH3

OH

H H

CH

CH3

OI

I

HO I

I

ONa

O

NH2H

5H2O

N

OH O OH O

OH

O

NH2

NH

OHN

OH

NH


T3357 Tioconazole (See page 16 for more information) 1 gC16H13Cl3N2OS FW 387.71 [65899-73-2] 5 gAntifungal agent. Potent inhibitor of cytochrome-P450. 25 gSomchit MN, Reezal I, Nur IE, Mutalib AR. J Ethnopharmacol. 84:1-4 (2003).

Alvarez J, Montero M, Garcia-Sancho J. J Biol Chem. 267:11789-11793 (1992).

Tioguanine (See Thioguanine)

T3468 Tirapazamine 10 mgC7H6N4O2 FW 178.15 [27314-97-2] 25 mgAn experimental anticancer drug that is activated to a toxic radical only at very low 100 mglevels of oxygen (hypoxia). Such levels are common in human solid tumors, a

phenomenon known as tumor hypoxia.

Denny WA (2004). "Prospects for hypoxia-activated anticancer drugs". Curr Med Chem Anti-Canc Agents 4 (5): 395–9

T5604 Tobramycin (free base) 25 mgC18H37N5O9 FW 467.51 [32986-56-4] 100 mgUsed in the treatment of respiratory infection and cystic fibrosis. 500 mgBrogden RN, Pinder RM, Sawyer PR. Drugs. 12:166-200 (1976).

T5605 Tobramycin Sulfate 100 mg(C18H37N5O9)2

.5H2SO4 FW 1425.45 [79645-27-5] 500 mgUsed in the treatment of respiratory infection and cystic fibrosis. 1 gBrogden RN, Pinder RM, Sawyer PR. Drugs. 12:166-200 (1976).

T5846 Tolfenamic Acid 5 gC14H12ClNO2 FW 261.70 [13710-19-5] 25 gNon steroidal anti-inflammatory agent. Found to inhibit COX-2 isoenzymes in 50 gdogs. Analgesic property is due to activation of Ca2+-activated K+ channels.

Kay-Mugford P, Benn SJ, LaMarre J, Conlon P. Am J Vet Res. 61:802-810 (2000).

Li L, Vaali K Vapaatalo H, Kankaanranta H. Eur J Pharmacaol. 383:169-176 (1999).

T5944 Tolmetin Sodium 1 gC15H14NNaO3

.2H2O FW 315.30 [64490-92-2] 5 gAnti-inflammatory, antirheumatic agent. 25 gLewis JR. JAMA 237:1260-1261 (1997).

T5946 Toltrazuril 1 gC18H14F3N3O4S FW 425.38 [69004-03-1] 5 gAn anticoccidial agent. Its mode of action appears to be a reduction of redox 10 g enzymes such as succinate-cytochrome C reductase and NADH oxidase and fumarate oxidase.Harder A, Haberkorn A, Parasitol Res. 76:8-12 (1989).

T5847 Tolvaptan 25 mgC26H25ClN2O3 FW 448.94 [150683-30-0] 100 mgA potent human vasopressin V2-receptor antagonist. It increases serum sodium 500 mgconcentration in patients with euvolemic or hypervolemic hyponatremia.

Yamamura Y, Nakamura S, Itoh S, et al. J. Pharmacol Exp Ther. 287:860-7 (1998).

Schrier RW, Gross P, Gheorghiade M, et. al N Engl J Med 355:2099-112 (2006).

HN N

N

O

CH3

OO

CH3

O

SCF3

HN

CH3

Cl

COOH

O

N

S

N

Cl

Cl

Cl

N

NN

NH2

O

O

NCOONa

O CH3

H3C

2H2O

O

O

OOH

H2N

OH

H2NH2C

H2N

OH

HOH2C

H2N OH

O

NH2

.5H2SO4

O

O

OOH

H2N

OH

H2NH2C

H2N

OH

HOH2C

H2N OH

O

NH2

N

HO

O

HN

O

Cl


Tomoxetine Hydrochloride (See Atomoxetine Hydrochloride)

T5761 Topotecan Hydrochloride 1 mgC23H23N3O5

.HCl FW 459.91 [119413-54-6] 5 mgTopoisomerase I inhibitor that is a water soluble semisynthetic camptothecin derivative.

Rothenberg ML. Ann Oncol. 8:837-55 (1997).

T5769 Toremifene 500 mgC26H28ClNO FW 405.96 [89778-26-7] 1 gA chlorinated tamoxifen analogue. It competes with estradiol for estrogen 5 g receptors and has growth inhibitory effects on MCF-7 breast cancer cells. It causes growth inhibition of estrogen-sensitive breast cancer cells by inducing some cells to undergo apoptosis and by inhibiting other cells from entering mitosis.

Maenpaa JU, Ala-Fossi SL. Drugs Aging. 11:261-70 (1997).

Warri AM, Huovinen RL, Laine AM et al. J Natl Cancer Inst. 85:1412-8 (1993).

T5672 Tosufloxacin Tosylate 100 mgC19H15F3N4O3

.C7H8O3S FW 576.55 [115964-29-9] 500 mgAntimicrobial agent. 1 gMori S, Ohashi K, Akiyama H, Kansenshogaku Zasshi. 68:872-8 (1994).

T5677 Total Cell Death Assay Kit 125 TestsDistinguishes apoptosis from necrosis, leading to a more accurate assessment 250 Testsof cytolytic activity.

T5996 Tozasertib 25 mgC23H28N8OS FW 464.59 [639089-54-6] 100 mgTozasertib (VX680) is an Aurora kinase inhibitor found to suppress tumor growth. 250 mgHarrington EA, Bebbington D, Moore J, et al. Nat. Med. 10, 262-267 (2004).

Fei F, Stoddart S, Groffen J, Heisterkamp N. Mol. Cancer Ther. 9, 1318-1327 (2010).

T6802 Tramadol Hydrochloride 500 mgC16H25NO2

.HCl FW 299.84 [22204-88-2] 1 gAn analgesic, acts by inhibiting type 3 muocarinic receptors function via 5 g quinuclidinyl benzilate binding sites. It activates the mu and kappa opioid receptors.

Shiga Y, Minami K, Shiraishi M et al. Anesth Analg. 95:1269-73 (2002).

Sun HL, Zheng JW, Wang K et al. Life Sci. 72:1221-30 (2003).

T6803 Trandolapril (See page 25 for more information) 100 mgC24H34N2O5 FW 430.54 [87679-37-6] 250 mgIs an ACE inhibitor used to treat high blood pressure, it may also be used to treat 500 mg other conditions.Nakou, E. Expert Opinion on Pharmacotherapy (2008), 9(10), 1629-1639.

T6811 Tranexamic acid 5 gC8H15NO2 FW 157.21 [1197-18-8] 10 gAn antifibrinolytic agent. Inhibits plasmin-induced fibrinolysis by 50 gbinding plasmin.Iwamoto M. Thrombosis et Diathesis Haemorrhagica. 33:573-585 (1975).

Wellington K, Wagstaff AJ. Drugs. 63:1417-1433 (2003).

H3CO

H

OH

N

H3C CH3

HCl

N N

O

F

N

F

F

COOH

H2N

N

N

O

HO

N(CH2)

O

OOH

HCl

H3C

H

COOH

HH2N

H2CH2CCl

OCH2CH2N

CH3

CH3

N

CO2H

H

H

O

HN

CO2Et

NNH

HN

N

N S

NH

O

N

N


T6902 Tranilast 50 mgC18H17NO5 FW 327.34 [53902-12-8] 100 mgAnti-allergic agent with antiasthmatic property. It was found to have 500 mg antiangiogenic and antitumor activity.

Garcia Mesa M. Allergol Immunopathol (Madr). 18:53-6 (1990).

Yatsunami J, Aoki S, Fukuno Y. Int J Oncol. 17:1151-6 (2000).

Isaji M, Miyata H, Ajisawa Y et al. Br J Pharmacol. 122:1061-6 (1997).

T6903 Tranylcypromine Hydrochloride 250 mgtrans-2-phenylcyclopropylamine hydrochloride 1 gC9H11N.HCl FW 169.66 [1986-47-6]A monoamine oxidase (MAO) inhibitor. It reduces MAO catalyzed conversion of N-acetyl-1,6-diaminohexane(NAD-AH) to 6-acetamidohexanoic acid (AcHA), enhances cell differentiation induced by hexmethylene bisacetamide (HMBA) and its metabolite NAD-AH.

Snyder SW, Egorin MJ, Zuhowski EG et al. Cancer Commun. 2:231-6 (1990).

Tretinoin (See trans-Retinoic acid)

T7132 Triacetyl Resveratrol 10 mgC20H18O6 FW 354.35 [42206-94-0] 25 mgA resveratrol prodrug. One approach to increasing the half life of resveratrol in vivo 100 mgis acetylation of the phenolic OH groups. Deacetylation presumably takes place in vivo

or in intact cells via the action of intracellular esterases. P. Torres, et al. J. Agric. Food Chem. 58, 807 (2010)

T6834 Triacsin C 1 mgC11H17N3O FW 207.27 [76896-80-5] 5 mgA long-chain fatty acid acyl-CoA synthetase inhibitor demostrating vasodilating activities.Madusa et. al. J Lipid Res. 47: 87-98 (2006).

Hartman EJ, Omura S, Laposata M. Prostaglandins. 37: 655-71 (1989)

T6830 Triadimefon 5 gC14H16ClN3O2 FW 293.75 [43121-43-3] 10 gBayleton, a widely used fungicide. P450 inhibitor, induces brassinosteroid 25 g deficiency in plants.Asami T, Mizutani M, Shimada Y et al. Biochem J. 369:71-76 (2003).

T6831 Triadimenol 10 gC14H18ClN3O2 FW 295.76 [55219-65-3] 25 gTriazole-type fungicide. Identified as weak estrogen receptor agonists. 100 gVinggaard AM, Breinholt V, Larsen JC. Food Addit Contam. 16:533-542 (1999).

T7032 Triamcinolone 50 mgC21H27FO6 FW 394.43 [124-94-7] 250 mgGlucocorticoid capable of sustaining neuromuscular transmission during 1 g early motor nerve degeneration. Triamcinolone is also known to induce 5 gapoptosis in T lymphocytes.Hall ED, Riker WF, Baker T. Exp Neurol. 79:488-96 (1983).

Perrin-Wolff M, Bertoglio J, Bressac B et al. Biochem Pharmacol. 50:103-10 (1995).

Cl

OC(CH3)3

OH

N

N

N

NH2.HCl

Cl

OC(CH3)3

O

N

N

N

NNH

N

O

NH

O O

O

O

OH

CH3

CH3

H

F H

OH

O

HO

OH

OH

O

O

O

O

O

O

O


T6832 Triamcinolone acetonide 50 mgC24H31FO6 FW 343.50 [76-25-5] 250 mgAn antiinflammatory steroid inhibits the IgE-dependent release of histamine 1 g by human basophils and the growth of NEL-M1 human melanoma cells. 5 gSchleimer RP, MacGlashan DW Jr et al. J Immunol. 129:1632-6 (1982).

DiSorbo DM. Cancer Res. 46:3964-8 (1986).

T7044 Triamcinolone Acetonide Acetate 50 mgC26H33FO7 FW 476.53 250 mgA corticosteroid that induces chondrocyte apoptosis in an experimental arthritis 1 gmodel. 5 gNakazawa F, Matsuno H, Yudoh K et al. Clin Exp Rheumatol. 20:773-81 (2002).

T6933 Trichostatin A 1 mgC17H22N2O3 FW 302.37 [58880-19-6] 5 mgA histone deacetylase inhibitor. It induces apoptotic cell death in cancer cells. It induces pro-apoptotic genes like ID1, ID2, ID3, down regulates the anti-apoptotic genes,Hsp 27 and Bcl-xL and induces activities of calcium/ calmodulin dependent kinase II and protein kinase C, which have been assigned pro-apoptotic function.Suzuki T, Yokozaki H, Kuniyasu H et al. Int J cancer. 88:992-7 (2000).

Eickhoff B, Germeroth L, Stahl C et al. J Biol Chem. 381:1127-32 (2000).

T6932 Triflumizole (See page 16 for more information) 5 gC15H15ClF3N3O FW 345.75 [68694-11-1] 10 gA pesticide suspected by the EPA to be a cancer causing agent. 100 gDe Resende, G. Ciencia e Agrotecnologia (1996), 20(2), 168-172.

T7031 Triflumuron 10 gC15H10ClF3N2O3 FW 358.70 [64628-44-0] 25 gA chitin biosynthesis inhibitor. It has been shown to inhibit uridine 100 g incorporation into RNA.Klitschka GE, Mayer RT, Droleskey RE et al. Toxicol. 39: 307-315 (1986).

T7033 Trifluoperazine HCl 5 gC21H24F3N3S.2HCl FW 480.43 [440-17-5] 10 gA phenothiazine class calmodulin antagonist which is known for its inhibition 25 gof DNA synthesis and cell proliferation activities. It is shown to stimulate Egr-1 gene experession by modulating Ras/MEK/ERK and activation of the E1K-1 pathway in human fibrosarcoma HT1080 cells. Trifluoperazine also induces apoptosis in human cholangiocarcinoma cells in vitro, probably acting via the Fas system.Shin SY, Kim SY, Kim JH et al. J Biol Chem. (2000).

Pan G, Vickers SM, Pickens A et al. Am J Pathol. 155:193-203 (1999).

T6934 Trimebutine maleate 1 gC22H29NO5

.C4H4O4 FW 503.54 [34140-59-5] 5 gGastrointestinal antispasmotic.

Yamada K, Iizuka M, Takaiti O. Jpn J Pharmacol. 33:301-8 (1983).

T6935 Trimebutine base 10 gC22H29NO5 FW 387.47 [39133-31-8] 50 gAn opioid receptor agonist.

Luttecke K. J Int Med Res. 6:86-88 (1978).Kountouras J, Chatzopoulos D, Zavos C et al. Hepato-Gastroenterology. 49:193-197 (2002).

H3CO

H3CO

OCH3

O

N CH3

H3C

H3C

O

H3CO

H3CO

OCH3

O

N CH2

H3C

H3C

O

C4H4O4

S

N

CH2CH2CH2

CF3

N N CH3

NH

NH

ClOCF3

OO

Cl

FFF

N

O

CH3

N

N

NH

OH

N

H3C

CH3

O

CH3 CH3

O

CH3

CH3

H

F H

O

O

HO

OH

O

OCH3

CH3

CH3

CH3

H

F H

O

O

HO

O

O

OCH3

CH3

C

O

CH3


T7133 Trimetazidine 250 mgC14H22N2O3 FW 266.34 [5011-34-7] 1 gA vasodilator shown to exert a marked anti-ischemic effect on patients with left 5 gventricle dysfunction and moderate heart failure.

Tepliakov et. al. Klin Med (Mosk). 82: 57-62 (2004).

T7034 Trimethoprim 5 gC14H18N4O3 FW 290.32 [738-70-5] 25 gAntimicrobial agent. Trimethoprim-sulfamethoxazole (TMP-SMX) is widely used 100 g to treat urinary and respiratory tract infections and for prophylaxis and treatment of

P carinii infection. TMP-SMX combination may be used for patients with beta-lactam intolerance.

Cunha BA. Postgrad Med. 101:68-70 (1997).

Safdar A, Armstrong D. Clin Microbiol. 41:483-485 (2003).

T8134 trans-3,4',5-Trimethoxy-stilbene 100 mgC17H18O3 FW 270.32 [22255-22-7] 250 mgAnalog of resveratrol. Displays powerful antiangiogenic activity. Inhibits endothelial 1 gcell proliferation, sprouting, collagen gel invasion and morphogenesis; ID50=0.3-3µM.

Induces microtubule disassembly and tubulin depolymerization. Inhibits antigen-induced

release of TNF-α in RBL-2H3 cells. Acts as potent antagonist of AHR.

M.H. Pan, et al.; Mol. Carcinog. 47, 184 (2008).

M. Belleri, et al.; Mol. Pharmacol. 67, 1451 (2005).

T7035 Triptolide 1 mgC20H24O6 FW 360.40 [38748-32-2] 5 mgA diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium

wilfordi. It has inhibitory activity on breast, stomach, and leukemia HL-60 cells. Triptolide induces

apoptosis in tumor cells by blocking NF-KB activation and sensitizing tumor cells for TNF-a induced

programmed cell death.

Wei YS, Adachi I. Chung Kuo Yao Li Hsueh Pao. 12:406-10 (1991).

Chang WT, Kang JJ, Lee KY et al. J Biol Chem. 276:2221-7 (2001).

T7037 Triptorelin Acetate 10 mgC64H82N18O13 FW 1311.46 [140194-24-7] 25 mgA gonadotropin releasing hormone (GnRH) agonist. 100 mgWeiss JM, Polack S, Treeck O, Diedrich K, Ortmann O. Endocrine. 30:139-44 (2006).

T7036 Triptorelin, [DTrp6]-LH-RH, Amide 10 mg C64H83N18O13 FW 1311.5 [57773-63-4] 25 mgA GnRH agaonist shown to inhibit estradiol-induced cancer cell proliferation.

Grundker C, Gunthert AR, Hellriegel M et al. Eur J Endocrinol. 151(5):619-628 (2004).

T7135 Triticonazole (See page 16 for more information) 5 gC17H20ClN3O FW 317.81 [131983-72-7] 10 gA pesticide suspected by the EPA of being a carcinogen. 100 gBoerjesson, E. Journal of Environmental Quality (2003), 32(4), 1258-1261.

T7056 Troglitazone 10 mgC24H27NO5S FW 441.54 [97322-87-7] 50 mgA novel antidiabetic agent. It is found to exert significant cell cycle arrest and 100 mg apoptosis in hepatocellular carcinoma cell lines. It has a unique property of

selectively inducing EGR-1 gene independent of PPARg. Potential preventive agent for colon carcinogenesis.

Fugiwara T, Horikoshi H. Life Sci. 67:2405-16 (2000).

Osawa E et al. Gastroenterology. 124:361-367 (2003).

Baek SJ, Wilson LC, His LC, Eling TE. J Biol Chem. 278:5845-53 (2003).

pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-

Arg-Pro-Gly-NH2

Glp-His-Trp-Ser-Tyr-D-Trp-Leu-

Arg-Pro-Gly-NH2

O

CH3

CH3

H3C

HO

CH3

CH2O CH2

NH

S O

O

H

ClHO

CH3

H3C

NN

N

O

O

CH3

O

OH

O

CH3

CH3

OH

N

N

OCH3

H3CO

H3CO

NH2

NH2

N

HN

OCH3

OCH3

H3CO

O

O

O


T7158 Tropicamide 100 mgC17H20N2O2 FW 284.35 [1508-75-4] 500 mgA specific muscarinic (M4) antagonist. 1 gBlessel K W et al. Anal Profiles Drug Subs. 3:565-80 (1974).

T7156 Tropisetron Hydrochloride 10 mgC17H20N2O2

.HCl FW 320.82 [105826-92-4] 50 mgA 5-hydroxytryptamine 3 receptor antagonist. Found to be a potent and selective 100 mgpartial agonist at a7 nicotinic receptors.

Tonini M, Candura SM Onori L et al. Life Sci. 50:PL173-8 (1992).

T7197 Tryprostatin A 0.5 mgC22H29N3O3 FW 383.48An antimitotic agent that interferes with the interaction between tubulin and microtubular

association protein.Osada H. Current Med Chem. 10:727-732 (2003).

T7676 HT-2 Toxin 1 mgC22H32O8 FW 424.48 [26934-87-2] 5 mgA semi-synthetic mycotoxin derived from T2 toxin.

Yoshizawa T, Kohno H, Ikeda K, et al. Biosci Biotechnol Biochem. 68:2076-85 (2004).

T8004 Tubeimoside I 10 mgC63H98O29 FW 1319.43 [102040-03-9] 25 mgA triterpenoid saponin isolated from tubers of bolbostemma paniculatum, 100 mgFranquet, a traditional Chinese medicine "Tu-Bei-Mu". Used as anti-tumor agent,

induces cell cycle arrest and apoptosis.

Yang P, Yu Tx, Ma RD et al. Ai Zheng. 21:346-350 (2002).

T8020 Tuftsin 5 mgC21H40N8O6 FW 500.60 10 mgAn endogeneous peptide that is known to have immunogenic activity against 25 mg tumors and pathogens by potentiating monocytes, macrophages, and polymorphonuclear leukocytes.

Gupta CM, Haq W. Methods Enzymol. 391: 291-304 (2005).

T8145 Tulobuterol 1 gC12H18ClNO FW 227.73 [41570-61-0] 5 gA beta-adrenoreceptor agonist used in the treatment of moderate to severe asthma.

Yoshihara S, Yamada Y, Abe T, Arisaka O. Ann Allergy Asthma Immunol. 96: 879-80-(2006).Nishiyama et. al. Clin Exp Pharmacol Physiol. 33:1016-21 (2006).

T8153 Tunicamycin 1 mgC40H66N4O16 Avg. FW 840.0 [11089-65-9] 5 mgA glucosamine-containing pryrimidine nucleotide and an inhibitor of 10 mg glucosaminyl-1-phosphate transferase. It induces apoptosis in cultured brain neurons, Melanoma and SV40- transformed cells by inhibiting N-linked glycosylation.Lin TY, Wang SM, Fu WM, Chen YH, Yin HS. J Cell Biochem. 74:638-47 (1999).

Dricu A, Carlberg M, Wang M, Larsson O. Cancer Res. 57:543-8 (1997).

T9945 Tylosin tartrate 1 gC46H77NO17

.C4H4O6 FW 1066.2 [1405-54-5] 5 gA macrolide antibiotic used in animal feed. 10 gKnothe H. Infection. 5:183-7 (1977).

HN

N

O

O

O

H

HO

O

O

O

OHOHCH2OH

OH

HO

CH3CONH

OH

HO

NH

(CH2)8-11CH(CH3)2

O

H

HO

O

H

H H

OH

O

H O

OH

HO

HO

O

O

HO

HOO

O

OOH

OO

OH

HOHO

O

OO

O

HO

OH HO

O

OH

HN

CH3

H3C

H3C

Cl

H-Thr-Lys-Pro-Arg-OH

O

O

O

CH3

H3C

OH

CH3

O

H3C

OO

O

O

HO

H3C

OCH3OCH3

HO

N CH3

H3C

OOH

CH3OH

CH3

CH3

O

O

OH

O

OH

HO

HO

.

HN

N

NH

CH3

OCH3

H3CO

OH

H

N

O

CH3

O

HN

HCl

N

OH CH3N

O

O

O

OO

O

H

O

OH

H

OH


T9946 Tylosin phosphate 1 gC46H77NO17

.H3PO4 FW 1014.11 [1405-53-4] 5 g10 g

T9974 [Asp371] Tyrosinase (369-377), human 1 mg C42H66N10O16S2 FW 1031.2 [9002-10-2]

T9968 Tyrphostin A25 5 mgC10H6N2O3 FW 202.17 [118409-58-8] 25 mgProtein tyrosine kinase inhibitor.

Gazit, A. et al. J Med Chem. 32:2344-52 (1989).

T9969 Tyrphostin AG490 5 mgC17H14N2O3 FW 294.31 [134036-52-5] 10 mgA selectrive PDGF receptor autophosphorylation inhibitor. 25 mgKovalenko M et al. Cancer Res. 54:6106-6114 (1994).

Levitsky A, Gazit A. Science. 267:1782-1788 (1995).

T9970 Tyrphostin AG1295 1 mgC16H14N2 FW 234.30 [71897-07-9] 5 mgA specific and potent JAK-2 protein tyrosine kinase inhibitor. Found also to inhibit

EGF receptor autophosphorylation and induce apoptosis.

Levitzki A. Biochem. Pharmacol. 40:913-918 (1990).

Gazit A et al. J Med Chem. 34:1896-1907 (1991).

De Vos J et al. Br J Haematol. 109:823-828 (2000).

U0618 Ubenimex 10 mgBestatin 50 mgC16H24N2O4 FW 308.37 [58970-76-6] 100 mgUbenimex is an antitumor agent effective against murine syngeneic tumors including mouse

colon 26 and C1498 leukemia. It was found to be active against MNNG-induced rat tumor

by oral administration. It also inhibits leucine aminopeptidase and aminopeptidase B in cell

membrane, in addition to modulating PKC in K562 cells and inducing apoptosis.

Sekine K, Fujii H, Abe F. Leukemia. 13:729-34 (1999).

Tsukagoshi S. Gan To Kagaku Ryoho. 14:2385-91 (1987).

Ebihara K, Abe F, Yamashita T et al. J Antibiot. 39:966-70 (1986).

U5232 Uniconazole (See page 16 for more information) 5 gC15H18ClN3O FW 291.78 [83657-22-1] 10 gTriazole plant growth inhibitor that suppresses the gibberelin and sterol 100 g biosynthesis. The pesticide is suspected of being a carcinogen.

Uniconazole P; pesticide tolerances. Federal Register (2008), 73(173), 51732-51736.

U5233 Universal TT epitope P2 (830-844) 1 mgC80H129N19O23 FW 1725.03 2 mgAddition of this peptide to vaccines enhances the efficacy of the immune 5 mgresponse to malaria prophylaxis.Fryauff DJ, Mouzin E and Church LW. et. al.Vaccine. 17: 59-63 (1999).

U6118 Uperolein 1 mgC57H79N13O16S FW 1234.42 2 mgA physalaemin-like endecapeptide that is selective for Neurokinin 1 receptor. 5 mgDike A, Cowsik SM. J Struct Biol. 156: 442-52 (2006).

Tyr-Met-Asp-Gly-Thr-Met-Ser-

Gln-Val

Cl

NN

N

HO

CH3H3CCH3

NH

CH3

O COOH CH3NH2

OH

O

O

O

CH3

H3C

OH

CH3

O

H3C

OO

O

O

HO

H3C

OCH3OCH3

HO

N CH3

H3C

OOH

CH3OH

CH3

CH3

O

H3C

H3C N

N

CN

CNHO

HO

OH

CN

HO

HO

NH

O

Gln-Tyr-Ile-Lys-Ala-Asn-Ser-

Lys-Phe-Ile-Gly-Ile-Thr-Glu-

Leu

pGlu-Pro-Asp-Pro-Asn-Ala-

Phe-Tyr-Gly-Leu-Met-NH2


U6901 Uracil 10 gC4H4N2O2 FW 112.09 [66-22-8] 25 gUsed in the treatment of metastatic colorectal cancer and hormone refractory 100 gprostate cancer.

Lin JK, Fan FS, Yen CC et al. Jpn J Clin Oncol. 30:510-4 (2000).

Nishimura K, Nomomura N, Ono Y et al. Oncology. 60:49-54 (2001).

U6801 Urapidil 500 mgC20H29N5O3 FW 387.48 [34661-75-1] 1 gAn a1-adrenergic antagonist. In addition, it has high affinity and selectivity for 5 gcentral 5-hydroxytryptamine binding sites and inhibits platelet aggregation.

Klemm K, Prusse W, Kruger U. Arzneimittelforschung. 27:1895-7 (1977).

Doods HN, Boddeke HW, Kalkman HO et al. J Cardiovasc Pharmacol. 11:432-7 (1988).

Storck J, Ochs JG, Kirsten R. Int J Clin Pharmacol Ther Toxicol. 28:303-8 (1990).

U6802 Urapidil hydrochloride 500 mgC20H29N5O3

.HCl FW 423.93 [64887-14-5] 1 g5 g

U6854 Urocortin, human 0.5 mgC204H337N63O64 FW 4696.3 [171543-83-2] 1 mgA CRF-related peptide involved in the relaxation of pulmonary arteries. 2.5 mgLau CW, Chan YC, Yao X. Eur J Pharmacol. 488:169-172 (2004).

U6855 Urocortin, rat 0.5 mgC206H338N62O64 FW 4707.37 1 mg

2.5 mg

U6856 Urocortin II, human 0.5 mgC194H338N63O54S1 FW 4449.31 1 mgA selective CRF receptor type 2 agonist that enhances contractility of ventricular 2.5 mg mycocytes in rabbit.Yang LZ, Kockskamper J, Heinzel FR. et. al. Cardiovasc Res. 69: 402-11 (2006).

U6858 Urocortin II, mouse 0.5 mgC187H320N56O50 FW 4152.98 1 mg

2.5 mg

U6859 Urocortin III, human 0.5 mgC185H307N53O50S2 FW 4137.96 1 mgA selective CRF receptor type 2 agonist that exhibits bronchorelaxant and 2.5 mganti-inflammatory activities.

Moffatt JD, Lever R, Page CP. FASEB J. 20:1877-9 (2006).

U6860 Urocortin III, mouse 0.5 mgC186H312N52O52S2 FW 4173.01 1 mg

2.5 mg

H-Asp-Asn-Pro-Ser-Leu-Ser-

Ile-Asp-Leu-Thr-Phe-His-Leu-

Leu-Arg-Thr-Leu-Leu-Glu-Leu-

Ala-Arg-Thr-Gln-Ser-Gln-Arg-

Glu-Arg-Ala-Glu-Gln-Asn-Arg-

Ile-Ile-Phe-Asp-Ser-Val-NH2

H-Asp-Asp-Pro-Pro-Leu-Ser-

Ile-Asp-Leu-Thr-Phe-His-Leu-

Leu-Arg-Thr-Leu-Leu-Glu-Leu-

Ala-Arg-Thr-Gln-Ser-Gln-Arg-

Glu-Arg-Ala-Glu-Gln-Asn-Arg-

Ile-Ile-Phe-Asp-Ser-Val-NH2

H-Ile-Val-Leu-Ser-Leu-Asp-

Val-Pro-Ile-Gly-Leu-Leu-Gln-

Ile-Leu-Leu-Glu-Gln-Ala-Arg-

Ala-Arg-Ala-Ala-Arg-Glu-Gln-

Ala-Thr-Thr-Asn-Ala-Arg-Ile-

Leu-Ala-Arg-Val-Gly-His-Cys-

NH2

H-Val-Ile-Leu-Ser-Leu-Asp-

Val-Pro-Ile-Gly-Leu-Leu-Arg-

Ile-Leu-Leu-Glu-Gln-Ala-Arg-

Tyr-Lys-Ala-Ala-Arg-Asn-Gln-

Ala-Ala-Thr-Asn-Ala-Gln-Ile-

Leu-Ala-His-Val-NH2

H-Phe-Thr-Leu-Ser-Leu-Asp-

Val-Pro-Thr-Asn-Ile-Met-Asn-

Leu-Leu-Phe-Asn-Ile-Ala-Lys-

Ala-Lys-Asn-Leu-Arg-Ala-Gln-

Ala-Ala-Ala-Asn-Ala-His-Leu-

Met-Ala-Gln-Ile-NH2

H-Phe-Thr-Leu-Ser-Leu-Asp-

Val-Pro-Thr-Asn-Ile-Met-Asn-

Ile-Leu-Phe-Asn-Ile-Asp-Lys-

Ala-Lys-Asn-Leu-Arg-Ala-Lys-

Ala-Ala-Ala-Asn-Ala-Gln-Leu-

Met-Ala-Gln-Ile-NH2

OCH3

N

N

HN

N

N

CH3

O

H3C

O

HCl

NH

HN O

O

OCH3

N

N

HN

N

N

CH3

O

CH3

O


U6857 Urodilatin CCC/ANP-95-126 1 mgC145H234N52O44S3 FW 3506.0 [115966-23-9]A renal natriuretic peptide that has been shown to possess a vasodilatory effect in pulmonary

circulation.Schermuly RT, Weissman N, Enke B et al. Am J Respir Cell Mol Biol. 25:219-225 (2001).

U6956 Uroguanylin, human 0.5 mgC64H102N18O26S4 FW 1667.89 1 mgAn endogenous ligand that binds and stimulates intestinal guanylate cyclase-C. 2.5 mgWhitaker TL, Steinbrecher KA, Copeland NG, Gilbert DJ, Jenkins NA, Cohen MB. Genomics. 45: 348-54 (1997).

U6957 Urotensin I 0.5 mgC210H340N62O67S2 FW 4869.55 1 mgA neuroprotective that increase the survival rate of central and peripheral 2.5 mgneuronons by activation of cAMP-dependent pathways.

Facci L,StevensDA,Pangallo M, Franceschini D, Skaper SD, Strijbos PJ. Neuropharmacology. 45: 623-36 (2003).

Marshall WS, Bern HA. Gen Comp Endocrinol. 43: 484-91 (1981).

U6958 Urotensin II (Frog) 0.5 mgC69H96N16O19S2 FW 1517.76 1 mgA neuropeptide that inhibits the active chloride transport of teleost fish. 2.5 mgMarshall WS, Bern HA. Gen Comp Endocrinol. 43: 484-91 (1981).

U6959 Urotensin II, human 0.5 mgC64H85N13O18S2 FW 1388.6 1 mg

2.5 mg

U6873 Ursodeoxycholic acid 1 gC24H40O4 FW 392.57 m.p. 203-2040C [128-13-2] 5 gA bile acid with significant chemopreventive activity in the colon.

Wali RK, Frawley BP, Hartmann S et al. Cancer Res. 55:5257-5264 (1995).

U7354 Usnic acid 5 gC18H16O7 FW 344.32 [125-46-2] 25 gAn antimicrobial, antitumor and enzyme inhibiting agent. Shown to uncouple oxidative

phosphorylation in mouse-liver mitochondria. Induces necrosis in certain cells.

Abo-Khatwa AN, al-Robai AA, al-Jawhari DA. Natural Toxins. 4:96-102 (1996).

Han D, Matsumaru K, Kettori D, Kaplowiz N. Biochem Pharm. 67:439-451 (2004).

V0045 Valacyclovir Hydrochloride 50 mgC13H20N6O4

.HCl FW 360.80 [124832-27-5] 100 mgL-valine ester of acyclovir that increases oral absorption before conversion to 500 mgacyclovir.

Ormrod D, Scott LJ, Perry CM. Drugs. 59:839-63 (2000).

O

OH

H3C

HO

O

H3C

O

H3C

O

O

CH3

H-Thr-Ala-Pro-Arg-Ser-Leu-

Arg-Arg-Ser-Ser-Cys-Phe-Gly-

Gly-Arg-Met-Asp-Arg-Ile-Gly-

Ala-Gln-Ser-Gly-Leu-Gly-Cys-

Asn-Ser-Phe-Arg-Tyr-OH


H-Asn-Asp-Asp-Cys-Glu-Leu-

Cys-Val-Asn-Val-Ala-Cys-Thr-

Gly-Cys-Leu-OH


H-Asn-Asp-Asp-Pro-Pro-Ile-

Ser-Ile-Asp-Leu-Thr-Phe-His-

Leu-Leu-Arg-Asn-Met-Ile-Glu-

Met-Ala-Arg-Ile-Glu-Asn-Glu-

Arg-Glu-Gln-Ala-Gly-Leu-Asn-

Arg-Lys-Tyr-Leu-Asp-Glu-Val-

NH2

H-Ala-Gly-Asn-Leu-Ser-Glu-Cys-

Phe-Trp-Lys-Tyr-Cys-Val-OH


H-Glu-Thr-Pro-Asp-Cys-Phe-

Lys-Tyr-Cys-Val-OH


HOHOH

CO2H

HN

N N

N

O

H2N

OO

O

NH2

HCl


V0245 Valdecoxib (See page 17 for more information) 5 mgC16H14N2O3S FW 314.36 [181695-72-7] 10 mgA prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis 25 mg and it is classified as an NSAID.

Roumie, Christianne L. Stroke (2008), 39(7), 2037-2045.

V0244 Valganciclovir Hydrochloride 25 mgC14H22N6O5 FW 354.36 [175865-59-5] 50 mgValganciclovir is the L-valyl ester of ganciclovir, a prodrug that is rapidly converted 100 mgto ganciclovir by esterases.

Segarra-Newnham M, Salazer MI, Pharmacotherapy 22:1124-8 (2002).

V0145 Valinomycin 5 mgC54H90N6O18 FW 1111.32 [2001-95-8] 10 mgA potassium ionophore that is well known to cause the collapse of the 25 mgmitochondrial membrane potential, which precedes cytoplasmic acidification,

cysteine-active-site protease activation, DNA fragmentation and apoptotic cell death.

Inai Y, Yabuki M, Kanno T et al. Cell Struct Funct. 22:555-63 (1997).

Furlong IJ, Lopez Mediavilla C, Ascaso R et al. Cell Death Differ. 5:214-21 (1998).

V0147 Valproic Acid Sodium Salt (See page 21 for more info) 10 gC8H15NaO2 FW 166.19 [1069-66-5] 25 gClinically used anti-convulsant and mood stabilizing drug. Used for epilepsy, 100 g bipolar disorders. It is also used in the treatment of migraine headaches.

Mechanism of action is believed to be through the GABA neurotransmission pathways.

Quenby, S. M. European Journal of Obstetrics & Gynecology and Reproductive Biology (2008),137(1), 31-36.

V0146 Valsartan 1 gC24H29N5O3 FW 435.52 [137862-53-4] 5 gNonpeptide angiotensin II AT1-receptor antagonist. 25 gMerck Index, 13rd ed. Merk & Co., Inc. Whithouse Station, NJ.349, (2001).

V0252 Vancomycin Hydrochloride (See page 32 for more info) 100 mgC66H75Cl2N9O24

.HCl FW 1485.73 [1404-93-9] 250 mgA glycopeptide antibiotic that is commonly used for treatment of methicillin 1 gresistant bacteria. It has been shown to inhibit glucose 6-phosphate dehydrogenase in vitro.

Beydemir S, Kulacoglu DN, Ciftci M, Kfrevioglu OI. Eur J Ophthal. 13:155-161 (2004).

Homer P, Peyman GA, Koziol J, Sanders D. Acta Ophthal. 53:311-320 (1975).

V0352 Vandetanib (See pages 24 and 29 for more information) 5 mgC22H24BrFN4O2 FW 475.35 [443913-73-3] 25 mgAn antagonist of the vascular endothelial growth factor receptor (VEGFR) and the 100 mgepidermal growth factor receptor (EGFR). It is a tyrosine kinase inhibitor.

Prueitt, R., et al.: Int. J. Cancer, 120, 796 (2007)

V0153 Vanilloid Receptor Subtype 1 (VR1) 1 mgC75H117N18O28S2 FW 1783.0 2 mgA heat-gated ion channel that mediates responses fo sensory neurons. 5 mgCaterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D. Nature 398: 436-41 (1999).

H-Cys-Glu-Asp-Ala-Glu-Val-

Phe-Lys-Asp-Ser-Met-Val-Pro-

Gly-Glu-Lys-OH

HO OH

HN

OHN

O

O

H

NH

HO

OCl

HOOC

H

H

H

NH

HN

O

O

O

H

NH2O

H

OH

O Cl

NH

H3C

CH3

O

OH

H

HN

CH3

H

O

OH

O

O

NH2

CH3H3C

HO

OH

HO

.HCl

ONa

O

NO

S

H2N

O

O

CH3

HN

O

NH

O

NH

O

O

NH

O

NH

O

NH

O

O

O

O

O

O

O

O

O

O

O

O

CH(CH3)2

CH3

(H3C)2HC

CH(CH3)2

CH(CH3)2

CH(CH3)2

H3C

CH(CH3)2

(H3C)2HC

CH(CH3)2

(H3C)2HC

CH3

N

N

O

N

O

HN

F

Br

NH

NN

N

NOO

OH

N

HN

N

N

O

H2N

O

OH

OO

H2N


V0160 RC-160 (Vapreotide) 0.5 mgC57H70N12O9S2 FW 1131.4 [103222-11-3] 1 mgAn octapeptide derivative of somatostatin (SRIF) capable of inhbiting growth 2.5 mg in OV-1063 humanepithelial cancer cells.Yano T, Radulovic S, Osuga Y et al. Oncology. 59 suppl 1:45-49 (2000)

V0269 Vardenafil Dihydrochloride 10 mgC23H32N6O4S 2HCl FW 561.52 [224789-15-5] 25 mgVardenafil is a PDE5 inhibitor. 100 mgKim NN, Huang YH, Goldstein I, et al. Life Sci. 69: 2249-56 (2001).

Bischoff E, Niewoehner U Haning H, et al. J. Urol. 165:1316-8 (2001).

V0369 Varenicline Tartrate 10 mgC13H13N3

.C4H6O6 FW 361.35 [375815-87-5] 25 mgA nicotinic receptor partial agonist. Varenicline is a partial agonist of the α4β2 100 mgsubtype of the nicotinic acetylcholine receptor. In addition it acts on α3β4 and weakly

on α3β2 and α6-containing receptors. A full agonism was displayed on α7-receptors.

Mihalak KB, Carroll FI, Luetje CW Mol. Pharmacol. 70 (3): 801–5 (2006).

V0273 Vasoactive Intestinal peptide (VIP) 0.5 mgC57H70N12O9S FW 3325.7 [40077-57-4] 1 mgA neuropeptide that exhibits anti-inflamatory properties by inducing regulatory 2.5 mgdendritic cells.

Gonzalez-Rey E, Delgado M. Gastroenterology. 131: 199-811 (2006).

V3360 VIP, guinea pig 0.5 mgVasoactive Intestinal peptide, guinea pig 1 mgC147H239N43O42S2 FW 3344.93 2.5 mg

V0274 [Lys8] Vasopressin 1 mgC46H65N13O12S2 FW 1056.24 2 mgA neurohypophyseal peptide that mediates central and peripheral antidiuretic 5 mg effects as a result of modifying four different G protein receptors.Pena A, Murat B, Trueba M et. al. J Med Chem. 50: 835-47 (2007).

V0275 [Arg8] Vasotocin 1 mgC43H67N15O12S2 FW 1050.23 2 mgA neuropeptide hormone that controls water and salt metabolism. 5 mgLeake RD, Weitzman RE. Clin Perinatol. 6: 65-85 (1979).

V0376 Vatalanib Dihydrochloride 5 mgC20H15ClN4

.2HCl FW 419.73 [212141-54-3] 10 mgProtein Kinase inhibitor under research for the treatment of solid tumors. 25 mgScott, E. N. Drugs of the Future (2007), 32(7), 607-613.

V1810 Vecuronium Bromide 10 mgC34H57BrN2O4 FW 637.74 [50700-72-6] 50 mgA nonpolarizing neuromuscular relaxant. 100 mgMarshall IG, Agoston S, Booij LH et al. Br J Anaesth. 52 Suppl 1:11S-19S (1980).

N

CH3 H

CH3

N

O

O

H

H H

H3C

H3C

O

O

CH3

Br

D-Phe-Cys-Tyr-D-Trp-Lys-Val-

Cys-Trp-NH2

His-Ser-Asp-Ala-Val-Phe-Thr-

Asp-Asn-Tyr-Thr-Arg-Leu-Arg-


Tyr-Leu-Asn-Ser-Ile-Leu-Asn-

NH2

H-Cys-Tyr-Ile-Gln-Asn-Cys-

Pro-Arg-Gly-NH2


H-Cys-Tyr-Ile-Gln-Asn-Cys-

Pro-Arg-Gly-NH2


H-His-Ser-Asp-Ala-Leu-Phe-

Thr-Asp-Thr-Tyr-Thr-Arg-Leu-

Arg-Lys-Gln-Met-Ala-Met-Lys-

Lys-Tyr-Leu-Asn-Ser-Val-Leu-

Asn-NH2

N

N

HN

N

Cl

2HCl

N

N

HN

HO

O

OH

OOH

OH

N

NS

O

NN

HNNO O

O

2HCl


V1745 Veliparib (See page 30 for more information) 5 mgC13H16N4O FW 244.29 [912444-00-9]A potent inhibitor of both PARP-1 and PARP-2. It inhibits DNA repair and potentiates

cytotoxic agents such as cisplatin and cyclophosphamide.

CK Donawho et al. Clin. Cancer Res. 13:2728 (2007).

Liu SK et al. Radiother Oncol. 88:258-268 (2008).

V1854 Venlafaxine Hydrochloride 500 mgC17H27NO2

.HCl FW 313.87 [99300-78-4] 1 gA heterocyclic antidepressant inhibits the re-uptake of serotonin, norepinephrine, 5 g and dopamine.

Morton WA, Sonne SC, Verga MA. Ann Pharmacother. 29:387-95 (1995).

V1769 (±)Verapamil Hydrochloride 1 gC27N38N2O4

.HCl FW 491.07 [152-11-4] 5 gA calcium channel blocker with chemopreventive character. Verapamil was found to inhibit

carcinogen-induced aberrant crypt foci formation, mammary carcinogenesis, and pancreatic

carcinogenesis.

Wargovich MJ, Jimenez A, Mckee K et al. Carcinogenesis. 21:1149-55 (2000).

Soybir G, Koksoy F, Koyuncu H et al. Breast Cancer Res Treat. 50:193-9 (1998).

Nakaizumi A, Uehara H, Baba M et al. Cancer Lett. 105:23-7 9 (1996).

V1868 Veratramine 1 mgC27H39NO2 FW 409.60 [60-70-8] 5 mgUseful as a signal transduction inhibitor for treating tumors

Imamura, L., et al.: J. Trad. Med., 12, 129

V1870 Verruculogen 1 mgC27H33N3O7 FW 511.57 [12771-72-1] 5 mgA tremorgenic neurochemical produced by various soil fungi.

Paterson D, Shreeve B, Robberts B, MacDonald S, Appl Environ Microbiol. 42: 916-7 (1981).

Norris P, Smith C, De Belleroche J, Bradford H, Mantle P, Thomas A, Penny R. J Neurochem. 34: 33-42 (1980).

V1872 Vesicular Stomatitis Virus peptide 1 mgC44H66N12O12 FW 955.09 2 mgA antigenic peptide of vesicular stomatitis virus binds to H-2Kb antigens. 5 mgShibata K, Imarai M, van Bleek GM et. al. Proc Natl Acad Sci U S A. 89: 3135-9 (1992).

V3212 Vidarabine 100 mgC10H13N5O4 FW 267.24 [5536-17-4] 500 mgAnti-leukemic agent. 1 gHonma Y, Nitsu N. Leuk Lymphoma. 399:57-66 (2000).

V3345 Vildagliptin 10 mgC17H25N3O2 FW 303.40 [274901-16-5] 25 mgInhibits the inactivation of GLP-1[2][3] and GIP[3] by DPP-4, allowing GLP-1 and 100 mgGIP to potentiate the secretion of insulin in the beta cells and suppress glucagon release

by the alpha cells of the islets of Langerhans in the pancreas.

Ahren B, Landin-Olsson M, Jansson PA, et al. J Clin Endocrinol Metab. 2004 May;89(5):2078-84.

C(CH2)3NCH2CH2

CH3O

CH3O

CN

CH(CH3)2

CH3

OCH3

OCH3

HCl

Arg-Gly-Tyr-Val-Tyr-Gln-Gly-

Leu

HO

N

NN

N

NH2

O

HOH

HOH

HH

NN

NH3CO

OHOH

O

CH3O

H3CCH3

OO

CH3

H3CO

N

CH2

H3COH

HCl

HN

N

N

O

OH

NH

N

HN

H2N O

NH

OH

OH


V3253 Vinblastine sulfate 5 mgC46H59N4O9

.HSO4 FW 909.05 m.p. 2670C [143-67-9] 10 mgA vinca alkaloid isolated from Vinca rosea (periwinkle). It is an antimitotic agent 25 mgwhich binds to tubulin. Clinically used as an antitumor agent.

Gorman M et al. J Amer Chem Soc. 81:4745 (1959).

Mareel MM, De Brabander MJ. J Natl Cancer Inst. 61:787-92 (1978).

V5254 Vincristine sulfate 5 mgC46H56N4O10

.H2SO4 FW 923.05 m.p. >3000C [2068-78-2] 10 mgAn antimitotic agent which binds to tubulin. Clinically used as an antitumor agent. Induces apoptosis.

Mareel MM, Storme GA, De Bruyne GK, Van Cauwenberge RM. Eur J Cancer Clin Oncol. 18:199-210 (1982).

Harmon BV, Takano YS, Winterford CM, Potten CS. Cell Prolif. 25:523-36 (1992).

V3354 Vindesine sulfate 1 mgC43H55N5O7

.H2SO4 FW 852.02 [59917-39-4] 5 mgVindesine, a vinca alkaloid derived from vinblastine. Potentially useful against a 10 mg variety of solid and hematological malignancies. More often used in combination

regimens with cisplatin and ifosfamide.

Dancey J, Steward WP. Anticancer Drugs. 6:625-636 (1995).

Kodani T, Ueoka H, Kiura K et al. Lung Cancer. 36:313-319 (2002).

V3355 Vindoline 25 mgC25H32N2O6 FW 456.53 [2182-14-1] 100 mgMonomeric vinca-alkaloid, forms lower portion of the lead anti-tumor agents, 500 mgvinblastine and vincristine. Found to exhibit reciprocal cross-resistance to vincristine and vinblastine.

Fahy J. Curr Pharm Des. 7:1181-1197 (2001).

Inaba M, Nagashima K. Jpn J Cancer Res. 77:197-204 (1986).

V3454 Vinleurosine sulfate 10 mgC46H56N4O9

.H2O4S FW 907.04 [54081-68-4] 25 mgAn antineoplastic agent. 100 mgGailani S D, Cancer chemotherapy reports. Part 1 (1966), 50(1), 95-103

V3251 Vinorelbine base 1 mgC45H54N4O8 FW 778.93 [71486-22-1] 5 mgMember of vinca-alkaloid. It is used in the treatment of anthracycline-resistent 25 mg advanced breast cancer and recommended for the treatment of bronchial cancer.

Brown RE, Hutton J, Burrell A. Pharmacoeconomics. 19:1091-1102 (2001).

Ribet JP, Zalavari P, Commenges G et al. Ann Pharm Fr. 55:20-34 (1997).

V3252 Vinorelbine Ditartrate 1 mgC45H54N4O8

.2C4H6O6 FW 1079.10 [125317-39-7] 5 mgA chemotherapeutic agent effective against a number of solid tumors including non- 25 mgsmall-cell carcinoma, advanced prostatic carcinoma, breast cancer, head and neck cancer, and

Hodgkin's lymphoma. It induces apoptosis and caspase-3 (CPP32) expression in leukemia and lymphoma cells.Goa KL, Faulds D. Drugs Aging. 5:200-34 (1994).

Jones SF, Burris HA 3rd. Ann Pharmacother. 30:501-6 (1996).

Toh HC, Sun L, Koh CH, Aw SE. Leuk Lymphoma. 31:195-208 (1998).

N

N

H3C

H3CO

OH

HOH

NH2

O

H

CH3

N

NH

CH3

OH

OCH3

O

H2SO4

NH2

OH

N

N

CHHO

O

H

O

N

HSO4

CH3

CH3

CH3O

O

H3C

H

CH3

O

CH3

O

O

O

NH2

OH

N

N

CH3

HO

O

H

O

N

HSO4

CH3

CH3

CH3O

O

H3C

CH3

O

CH3

O

O

N H OH

CO2Me

OAc

HHN

NH

MeO2C

NO

MeO

S

O

O

HO OH

NH

N

N

N

CH3OH COOCH3

OCOCH3

CH2CH3

CH2CH3

H3CO

H3CO

O

H

H

H.2C4H6O6

NH

N

N

N

CH3OH COOCH3

OCOCH3

CH2CH3

CH2CH3

H3CO

H3CO

O

H

H

H

N

N

OH3C

H3CHHO

O

H

HCH3

CH3

OOCH3O


Vitamin A (See all trans-Retinol)

Vitamin B6 (See Pyridoxine HCl)

V3378 Vitamin B12 500 mgC63H88CoN14O14P FW 1355.37 [68-19-9] 1 gAlso known as methylcobalamin/cobalamine. Prevents chronic diseases, 5 g including cancer, coronary heart disease, and osteoporosis.

Fairfield KM, Fletcher RH. JAMA. 287:3116-31126 (2002).

Ames BN, Wakimoto P. Nat Rev Cancer. 2:694-704 (2002).

V3476 Vitamin D2 1 gC28H44O FW 396.65 [50-14-6] 5 gOne of the vitamin D family. It is used in the treatment of refractory rickets (vitamin D resistant

rickets), familial hypophosphatemia and hypoparathyroidism. It also has a strong inhibitory effect against bladder tumor promotion by sodium saccharin and induces cell differentiation in leukemia cells.

Yazawa Y, Yokota M, Sugiyama K, Biol Pharm Bull. 23:1298-302 (2000).

Yen A, Blue J, Forbes M. In vitro cell dev Biol. 27A:518-20 (1991).

Vitamin D3 (See Cholecalciferol)

V3276 Vitamin E, Natural 100 gD-a-Tocopherol [10191-41-0] 250 gIt has been claimed that _-tocopherol is the most important lipid-soluble

antioxidant, and that it protects cell membranes from oxidation by reacting with

lipid radicals produced in the lipid peroxidation chain reaction

Marzani, B. Journal of Nutrition (2008), 138(11), 2205-2211.

Armagan, A. Basic & Clinical Pharmacology & Toxicology (2008), 103(2), 166-170.

V3277 Vitamin E 100 gD,L-a-Tocopherol 250 gC29H50O2 FW 430.7 [10191-41-0]An antioxidant and anticarcinogen toward a variety of cancers.

Wattenberg LW. Cancer Res. 45:1-8 (1985).

V3479 Vitamin K3 10 g2-Methyl-1,4-naphthoquinone, menadione 25 gC11H8O2 FW 172.18 [58-27-5]Induces apoptosis in various cultured cells including leukemia cells. It has been shown that vitamin K exerts anti-tumor activity by inhibiting cdk1 activity and over expressing the c-myc gene to induce apoptotic cell death. Another hypothesis based on investigation done on the mode of actions of vitamin K suggests that VK3 induces apoptosis by promoting the generation of intracellular reactive oxygen intermediates and Fas/APO-1 expression.

Nishimaki J, Miyazawak, Yaguchi M et al. Leukemia. 13:1399-405 (1999).

Wu FY, Sun TP. Eur J Cancer. 35:1388-93 (1999).

Sun LK, Yoshii Y, Miyagi K. J Neurooncol. 47:31-8 (2000).

V5725 Voglibose 10 mgC10H21NO7 FW 267.28 [83480-29-9] 25 mgAn alpha-Glucosidase inhibitor. 100 mgMoritoh et al. J.Pharmacol.Exp.Ther. 329 669 (2009).

O

O

CH3

CH3

CH3

H3C

CH2

H

H

CH3

HO

CH3

O

CH3

H3C

OH

CH3

N N

NN

Co

H3CH3C

NH2

O

NH2

O

CH3

CH3

NH2

O

CH3

H3C

NH

O

OP

O

H2N

H2N

H2N

O

O

O

H3C

O

O

O HON

N CH3

CH3

HO

CN

H3CH3C

HO

OH

NH

HO OH

HO

OH

OH

O

HO


V5886 Voriconazole 100 mgC16H14F3N5O FW 349.31 [137234-62-9] 250 mgIs a triazole antifungal medication that is generally used to treat serious, invasive 1 gfungal infections.

Herbrecht R, Denning D, Patterson T, et al. N Engl J Med 347 (6): 408–15 (2002).

V5734 Vorinostat (See page 30 for more information) 100 mgC14H20N2O3 FW 264.32 [149647-78-9] 250 mgVorinostat is a member of a larger class of compounds that inhibit histone 1 gdeacetylases (HDAC). Histone deacetylase inhibitors (HDI) have a broad

spectrum of epigenetic activities.

Archin NM, Espeseth A, Parker D, et al. AIDS Res Hum Retroviruses 25: 207–12 (2009)

W0269 Warfarin 1 gC19H16O4 FW 308.33 [81-81-2] 10 gUsed for preventing thrombosis and embolism. A synthetic derivative of 25 g coumarin. Decreases blood coagulation by inhibiting vitamin K epoxide reductase.

Foerch, C. Stroke (2008), 39(12), 3397-3404.

W0270 Warfarin Sodium 1 gC19H15NaO4 FW 330.31 [129-06-6] 10 gUsed for preventing thrombosis and embolism. A synthetic derivative of 25 gcoumarin. Decreases blood coagulation by inhibiting vitamin K epoxide reductase.

Foerch, C. Stroke (2008), 39(12), 3397-3404.

W2933 WHI-P131 50 mgC16H15N3O3

. HCl FW 333.77 [202475-60-3] 250 mgJAK3 inhibitor. Inhibits human glioblastoma cell adhesion and invasion.

Increases survival in a mouse ALS model.

RK Narla et al Clin. Cancer Res. 4:2463 (1998).

VN Trieu et al Biochem. Biophys. Res. Commun. 267:22 (2000).

W3576 Withaferin A 1 mgC28H38O6 FW 470.6 [5119-48-2] 5 mgAn anti-cancer compound present in the roots and leaves of Withonia somnifera.

Displays marked tumor inhibiting activity. A novel angiogenesis inhibitor found in medicinal plants.

Mandal, C. Apoptosis (2008), 13(12), 1450-1464.

Oh, Jung Hwa. Apoptosis (2008), 13(12), 1494-1504.

W4096 W-K-Y-M-V-M-NH2 0.5 mgC41H61N9O7S2 FW 856.13 1 mgA formyl peptide receptor-like 1 ligand, induces superoxide production by 2.5 mghuman neutrophils.

Lee HY, Jo SH, Lee C, Baek SH, Bae YS. Biochem Pharmacol. 72: 860-8 (2006).

W5726 Wogonin (See page 15 for more information) 5 mg5,7-Dihydroxy-8-methoxyflavone 10 mgC16H12O5 FW 248.26 [632-85-9] 25 mgA flavanoid compound that exhibits cell apoptotic and cytotoxic effects in Bel-7402 cells.

This compound also demostrates anti-inflammatory and anti-cancer activities.

Yu JQ, Liu HB, Tian DZ, Liu YW, Lei JC, Zou GL. Hepatol Res. 37: 68-76 (2007).

Tai MC, Tsang SY, Chang LY, Xue H. CNS Drug Rev. 11:141-50 (2005).

H-Trp-Lys-Tyr-Met-Val-Met-

NH2

O

OOH

HO

OCH3

O O

O

CH3

ONa

O O

OH

CH3

O

H3C

OH

O

OHO

CH3

CH3

O

OH3C

F

N

N

N

N N

F

F

OH

HN

O

O

NH

OH

N

N

HN

OH

O

O

HCl


W5769 Wortmannin 1 mgC23H24O8 FW 428.43 [19545-26-7] 5 mgAn inhibitor of PI3-K and DNA-dependent protein kinase, which is known to mediate DNA double

strand break repair. It induces apoptosis and also sensitizes cells to ionizing radiation.

Boulton S, Kyle S, Yalcintepe L, Durkacz BW. Carcinogenesis. 17: 2285 -90 (1996).

Ng SSW, Tsao MS, Chow S, Hedley DW. Cancer Res. 60: 5451-5 (2000).

Kubota N, Okada S, Inada T, Ohnishi K, Ohnishi T. Cancer Lett. 161:141-7 (2000).

X1752 Xenin 0.5 mgC139H224N38O32S1 FW 2971.63 1 mgAn amphibian xenopsin-related peptide that stimulates exocrine pancreatic 2.5 mg secretion.

Feurle GE, Hamscher G, Kusiek R, Meyer HE, Metzger JW. J Biol Chem. 267: 22305-9 (1991).

Hamscher G, Meyer HE, Metzger JW, Feurle GE. Peptides. 16: 791-7 (1995).

X1753 Xenopsin 1 mgC47H73N13O10 FW 980.19 2 mg

5 mg

X1854 p-Xyleneselenocyanate, 99% (See page 12 for more info) 100 mg1,4-Phenylenebismethyleneselenocyanate, p-XSC 250 mgC10H8N2Se2 FW 314.10 m.p. 1560C [85539-83-9] 500 mgA synthetic organoselenium chemopreventive agent.

Found to inhibit chemically induced carcinogenesis in the mammary glands, colon and lung of laboratory animals.Tanaka T, Makita H, Kawabata K et al. Cancer Res. 57:3644-3648 (1997).

Prokopczyk B, Amin S, Desai DH et al. Carcinogenesis. 9:1855-1857 (1997).

Y0052 Yangonin 5 mgC15H14O4 FW 258.27 [500-62-9] 10 mgOne of the major components of kava extract reported to have

binding affinities to CNS receptors.

Dinh LD, Simmen U, Bueter KB. Planta Med. 67:306-11 (2001).

Z0146 Z-Ala-Ala-Leu-pNA 100 mgC26H33N5O7 FW 527.6 [61043-33-2] 250 mg

Zalcitabine (See 2',3'-Dideoxycytidine)

Z0252 Zanamivir 25 mgC12H20N4O7 FW 332.31 [139110-80-8] 100 mgAn influenza viral neuraminidase inhibitor. 250 mgMonto, A.S., et al.: J. Am. Med. Assoc., 282, 31 (1999),

Z1216 Z-D-E-V-D-AMC 5 mgAc-Asp-Glu-Val-Asp-7-amino-4-methylcoumarin 10 mgC36H41N5O14 FW 767.0 25 mgA fluorogenic peptide substrate used to determine caspase activties.

Haviv R, Lindenboim L, Li H, Yuan J, Stein R. J Neurosci Res. 50: 69-80 (1997).

CH2SeCN

CH2SeCN

O

O

O

OO

CH3

CH3

C

CH3OCH2

CH3OO

H-Met-Leu-Thr-Lys-Phe-Glu-

Thr-Lys-Ser-Ala-Arg-Val-Lys-

Gly-Leu-Ser-Phe-His-Pro-

Lys-Arg-Pro-Trp-Ile-Leu-OH

pGlu-Gly-Lys-Arg-Pro-Trp-Ile-

Leu-OH

Z-Ala-Ala-Leu-pNA

Z-Asp-Glu-Val-Asp-AMC

O

OCH3

O

OH3C

O

CO2H

NH

H2N

NH

H

OH

HOOH

NH

O


Z2268 Z-F-R-AMC 10 mgC33H36N6O6 FW 621.58 20 mgA peptide substrate used to experimentally determine cathepsin B and L activities. 50 mgLi Y. et. al. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 16: 101-4 (1998).

Z6269 Z-Pro-D-Leu 10 mgC19H26N2O5 FW 362.4 20 mgA synthetic peptide derived from the c-terminus fragment of oxytocin. It is an 50 mgeffective inhibitor of tolerance to and dependence on morphine in mice.

Kovacs GL, Acsai L, Tihanyi A, Faludi M, Telegdy G. Pharmacol Biochem Behav. 18: 345-9 (1983).

Z1602 Zearalenone 1 mgC18H22O5 FW 318.36 [17924-92-4] 5 mgAn estrogenic mycotoxin produced by genus Fusarium found in cerea grains. 10 mgZearalenone induced apoptosis and proliferation in granusola cells from cycling mare ovaries.Tiemann U, Danicke S. Food Addit Contam. 24: 306-14 (2007).

Minervini F, Giannoccaro A, Fornelli F. et. al. Reprod Biol Endocrinol. 4: 62 (2006).

Z1970 Zerumbone 10 mgC15H22O FW 218.33 [471-05-6] 50 mgA sesquiterpene phytochemical from ginger. It has been shown to suppress free radical generation, work as an anti-inflammatory, and suppress cancer cell proliferation.Kirana C, McIntosh GH, Record IR, et al. Nutr Cancer. 45:218-225 (2003).

Zidovudine (See 3'-Azido-3'-deoxythymidine (AZT))

Z3444 Zileuton 100 mgC11H12N2O2S FW 236.29 [111406-87-2] 250 mgIs an active oral inhibitor of the enzyme 5-lipoxygenase, which forms leukotrienes 1 gfrom arachidonic acidLu P, Schrag ML, Slaughter DE, Raab CE, Shou M, Rodrigues AD (November 2003).

Drug Metabolism and Disposition 31 (11): 1352–60.

Z3463 Ziprasidone 500 mgC21H21ClN4OS FW 412.94 [146939-27-7] 1 gAn anti-psycotic that blocks dopamine and serotonin receptors. It also inhibits the 5 gre-uptake of serotonin and norepinephrine by nerves in the brain like some anti-depressant drugs. Bench, C.J., et al.: Psychopharmacology, 112, 308 (1993)Goldstein, J.M., et al.: Exp. Opin. Invest. Drugs, 4, 291 (1995)

Z5645 Zoledronate Disodium 10 mgC5H8N2Na2O7P2 4H2O FW 390.13 [165800-07-7] 25 mgZoledronic acid is used as an antiresorptive agent in bone. 100 mgGreen, J. et al. J. Bone Min. Res. 9:745 (1994).

Z5744 Zoledronic acid (See page 27 for more information) 10 mgC5H10N2O7P2 FW 272.09 [118072-93-8] 25 mgA potent bone resorption inhibitor. May improve osteosarcoma treatments when 100 mg administered with anticancer agents.Schortinghuis J, Witjes MJ, Spijkervet KL, de Visscher JG. Ned Tijdschr Geneeskd. 151:314-8 (2007).

Horie N et. al.Br J Cancer. 96: 255-61 (2007).

Z5653 Zonisamide (See page 20 for more information) 10 mgC8H8N2O3S FW 212.23 [68291-97-4] 25 mgA new-generation antiepileptic drug (AED) with applications as an 100 mgantinocireceptive agent.Sakaue A, Honda M, Tanabe M, Ono H. J Pharm Sci. 95:181-8 (2004).

Low PA, James S, Peschel T et al. J Neur. 251:1043-9 (2004).

N

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Drug Discovery Kits

A Drug Discovery Kit Can be Used For... - Immediate assay - Activity screening - Standard references - Finding new uses for known compounds

Groups of biologically active spe-cialty chemicals placed in 96-well plates or 8-well strips in equimolar solution. Drug Discovery Kits can be used directly in your screening assay, diluted to suitable concentrations and/or added to pre-grown cells.

Benefits:• Brings a known concentration and

volume of materials to the researcher for quick activity screening.

• Saves time in sample preparation.• Saves money because the potential

activity can be determined before large monetary investments in chemical purchases are made.

• Can be customized by columns to fit the needs of the researcher

• Because only a small sample is provided, waste disposal is minimized.

The purpose of this product is to provide you with small samples of many of our specialty chemicals at a price that is affordable. Our delivery system is 100 microliters of a 1mM solution dissolved in 100% DMSO. These 96 well plates can then be used directly to test your research system, they can be diluted for a variety of concentration trials or they can be added to cells that have been grown in another location.

Drug Discovery Kits are...


See all of our kits on the following pages...


The following materials can be ordered as a part of the Drug Discovery Kit. Please select from the following groupings to be included in your plate.

Anti-Angiogenic Agents (AA) Antimicrobials (AM) Antineoplastics (AN) Apoptosis Inducers and Inhibitors (AP) Cancer Chemopreventive Agents (CP) Coffee Compounds (CF) Cyclovirs (CL) Natural Products (NP) NSAIDs (NA) Signal Transduction Reagents (ST) Taxol Derivatives (TT) Non-Categorized Chemicals (XX)

AA100 AA101 AA102 AA103 Paclitaxel Fluorouracil Tranilast Medroxyprogesterone 17-acetateCisplatin Ganciclovir Amiloride MifepristoneCyclophosphamide Glucosamine Dexamethasone BusulfanCyclosporin Hydroxyurea Forskolin ColchicineDacarbazine Indomethacin Curcumin SimvastatinDoxorubicin Carboplatin Oxaliplatin FlurbiprofenChalcone Clindamycin Palmitate Thalidomide Ipriflavone

Cyclohexamide N-4-(Hydroxyphenyl) retinamide

AA104 AA105 AA106 AA107 Corticosterone Nifidepine Somatostatin Acetylsalicylic Acid/ AspirinDoxycycline Mitomycin C Tetracycline AtorvastatinTamoxifen Citrate Genestein Omeprazole LovastatinHydrocortisone Penicillamine Aprotinin Pravastatin sodiumQuinacrine Pentoxifylline Tunicamycin Levamisole HClCaptopril Daidzein Ursodeoxycholic Acid GenisteinSuramin Wortmannin Prednisolone Minocycline HCl

Chlormadinone acetate

AA108 AA109 AA110 AM100Carmustine Cyclosporin A Camptothecin CarbadoxDifluoromethylornithine Cyclosporin C Camptothecin, 7-ethyl-10-hydroxy CefaclorEpigallocatechin gallate Cyclosporin D Camptothecin, 10-hydroxy Cefoperazone acidN-(4-Hydroxyphenyl) retinamide Cyclosporin H Camptothecin, 9-nitro-20(S) Cefoperazone sodiumLisinopril Docetaxel Irinotecan Cefotaxime acidVincristine Paclitaxel Topotecan Cefotaxime sodiumThalidomide Tetrandrine Radicicol CeftazidimeLavendustin A Tretinoin (trans-Retinoic acid) Staurosporine Chloramphenicol

AM101 AM102 AM103 AM104Acetylsalicylic acid/ Aspirin Levofloxacin HCl Cinoxacin Atropine sulfate4-Aminosalicylic acid Lincomycin HCl monohydrate Ciprofloxacin Bambuterol HCl4-Aminosalicylic acid sodium dihydrate Lomefloxacin HCl Clindamycin HCl Loperamide HClClobetasol Propionate Nadifloxacin Clinafloxacin HCl Losartan PotassiumDiflunisal Norfloxacin Enoxacin Sarafloxacin HCl6-Mercaptopurine monohydrate Ofloxacin Enrofloxacin SparfloxacinMethotrexate Pazufloxacin Fleroxacin TosufloxacinPaenol Rufloxacin Gatifloxacin Sulfadoxine

AM105 AM106 AM107 AM108 Bifonazole Miconazole Ampicillin trihydrate Bleomycin A5 HClClimbazole Miconazole nitrate Oxacillin sodium monohydrate Bleomycin sulfateFlubendazole Oxiconazole nitrate Penicillin G procraine CepharanthineFluconazole Oxfendazole Penicillin V potassium Mitomycin CItraconazole Oxibendazole Piperacillin Spectinomycin HClMebendazol Tioconazole Piperacillin sodium Tobramycin free baseMetronidazole Secnidazole Ethacridine lacate monohydrate Nifursol

Praziquantel Erythromycin thiocyanate

Drug Discovery Kits

The standard volume is 100 µl per well.


AM109 AM110 AM111 AM112 Daunorubicin HCl Acemetacin Arbutin FlorfenicolDemeclocycline Indomethacin Baicalin FurosemideDoxorubicin HCl Actinomycin D Curcumin AmitrazDoxycycline HCl Azithromycin Diosmin Cromolyn sodiumDoxycycline monohydrate Andrographolide, dehydro- Honokiol CyromazineOxytetracycline HCl Andrographolide, deoxy- Magnolol MeloxicamTetracycline Puromycin Rosmarinic acid TenoxicamTetracycline HCl Nystatin Shikimic acid Famciclovir

AM113 AM114 AM115 AM116Closantel Caerulomycin A Neomycin sulfate Betamethasone 21-phosphate sodium salt

Diclofenac sodium salt Clarithromycin Rapamycin Chlorpheniramine maleatePyrantel Pamoate Brefeldin A Ribavirin Fluocinolone acetonideα-Santonin Geldanamycin Rifampin HydrocortisoneProthionamide Gentamycin Rifamycin SV-3 formyl Tolfenamic acidPyrazinamide Ikarugamycin Rifamycin SV-Sodium CycloheximideRimantadine HCl Minocycline HCl Rifaximin TrimethoprimAtenolol Roxithromycin Tylosin tartrate

AM117 AM118 AM119 AM121 Nabumetone Fenbufen Allyl disulfide Bafilomycin B1Nimesulide Flurbiprofen Amantadine HCl Paromomycin Sulfate (50%DMSO)Colistin sulphate Ibuprofen Pefloxacine mesylate β-RubromycinTolmetin sodium S(+) Ibuprofen Suramin hexasodium salt SpiramycinTriamcinolone acetonide Ketoprofen Terbinafine HCl Spiramycin EmbonateScopolamine hydrobromide Amprolium HCl Primaquine Phosphate Spiramycin Hexanedioate Thiamphenicol Glycinate HCl Idoxuridine Modafinil Vancomycin HClEtoposide Povidone iodine

AM122 AM123 AM124 AM125Amoxicillin Anisomycin Carnosol ArtemetherAmphotericin B Erythromycin Cyclosporin B Artesunate Aztreonam Erythromycin Ethylsuccinate Ethambutol Ebselen

Chartreusin Kanamycin A (50% DMSO) Metronidazole (50% DMSO) DiaveridineChloramphenicol levo Kanamycin B (50% DMSO) Lansoprazole Diaveridine HClChlortetracycline HCl Natamycin Sulbactam sodium salt Diminazene AceturateCloxacillin Sodium Physcion Sulfamethoxazole Pyronaridine TetraphosphateMeropenam Usnic acid

AM126 AN100 AN101 AN102Aphidicolin Actinomycin Calcitriol Calcium folinate, pentahydrateBlasticidin S HCl (50% DMSO) Puromycin Cholecalciferol/ Vitamin D3 MethotrexateCrotamiton Carmofur Vitamin E (tocopherol) FtorafurD-Cycloserine (50% DMSO) Mitoxantrone Vitamin A Cyclocytidine HClGanciclovir Canthaxanthin .5 mmol Vitamin K3 HydroxyureaKetoconazole Carnosic acid Biochanin A LomustineMethotrexate Lisinopril Genistein 6-Mercaptopurine monohydrateNigericin Tenoxicam

AN103 AN104 AN105 AN106Camptothecin Ifosfamide Daunorubicin HCl CorticosteroneCamptothecin, 7-ethyl-10-hydroxy Nocodazole Dihydrokainic acid HydrocortisoneCamptothecin, 10-hydroxy Suramin hexasodium salt Doxorubicin HCl Medroxyprogesterone 17-acetateCatharanthine base Vinblastine sulfate Doxycycline Monohydrate Megestrol acetateCatharanthine sulfate Vincristine sulfate Doxycycline HCl MethylprednisoloneCatharanthine tartrate Vindesine sulfate Epirubicin MifepristoneIrinotecan Vindoline Tetracycline PrednisoloneTopotecan Vinorelbine base Etoposide Prednisolone Na phosphate in 50% DMSO

AN107 AN108 AN109 AN110 Carboplatin Levamisole HCl Podophyllotoxin ExemestaneNedaplatin Palmatine Teniposide FlutamideOxaliplatin Cyclophosphamide DL-Homocysteine thiolactone HCl Tamoxifen citrateSatraplatin Harringtonin Hydroquinone ToremifeneAcemetacin Hexamethonium bromide hydrate Uracil DocetaxelKaempferol Homoharringtonin Procarbazine HCl Ibandronate .5 mmol 50% DMSOMeloxicam Sulfadiazine Puerarin QuinacrineCatechin Chlorambucil Troglitazone Paclitaxel, (Taxol)


AN111 AN112 AN113 AN114 trans-Anethole Adenine Alloxan monohydrate Copper bis-3,5-diisopropylsalicylate

18 β-Glycyrrhetinic acid Bestatine HCl Caerulomycin A Lavendustin AGlycyrrhizic acid Busulfan Gallic acid Phorbol-12-myristate-13-acetatePerillyl alcohol Colchicine Melphalan Tamsulosin HClD-Limonene Mevastatin Phenethyl caffeate Terazosin HClTriptolide Simvastatin Allopurinol ThalidomideTubeimoside I .1 mmol Vidarabine Difluoromethylornithine TranilastRubescensin A Norepinephrine Ketoconazole Acivicin

AN115 AN116 AN117 AN118Altretamine 3-Aminobenzamide Cytarabine AlfacalcidolDanazol Aphidicolin Doxifluridine 4-DemethylepipodophyllotoxinHydroquinone Mitomycin C Floxuridine AlfacalcidolIonomycin Nimustine Ribavirin LonidamineMESNA Trichostatin A Zalcitabine StreptozocinMiconazole Trifluoperazine Hypocrellin A ToremifeneTheophylline Bleomycin A5 HCl Hypocrellin B Usnic Acid5-Fluorouracil Bleomycin sulfate Captopril

AN119 AN120 AP100 AP101 DL-Aminoglutethimide Amygdalin Adenine Bestatine HydrochlorideBicalutamide N-acetyl-L-cysteine 3-Aminobenzamide 1,4-BenzoquinoneDiflubenzuron Diflubenzuron 6-Aminonicotinamide Bleomycin A5 hydrochloridePurvalonol A Matrine Ascorbic acid Brefeldin AScriptaid β-Rubromycin Bafilomycin A1 n-Butyric acidToremifene Streptozocin Baicalin Phenethyl caffeatep-Xyleneselenocyanate Tryprostatin A Wortmanin Acivicin

Baccatin III

AP102 AP103 AP104 AP105 Biochanin A 3,3'-Diindolylmethane Colchicine Fumonisin B1Cerulenin Disulfiram Concanavalin A (DMSO/ Tris Buffer) GalactosamineChenodeoxycholic acid Etoposide Copper bis-3,5-diisopropylsalicylate GenisteinChlorambucil Farnesol Corticosterone Epigallocatechin gallateChlorpromazine 5-Fluorouracil Cyproterone Acetate Hexamethylene bisacetamideChloroadenosine Flurbiprofen Cycloheximide Hydroxyphenyl retinamideClofibrate Flavanone Demecolcine Atorvastatin

Tunicamycin Diethylstilbestrol Ibuprofen

AP106 AP107 AP108 AP109 Ionomycin 6-Mercaptopurine monohydrate Piroxicam StaurosporineKaempferol Methylprednisolone Prednisolone Sulindac, sulfideKetoprofen Nifidepine Puromycin Tamoxifen citrateValinomycin Nocodazole Somatostatin TetracyclineLevonorgestrel Pentoxifylline D-Sphingosine TetrandrineCurcumin Perillyl Alcohol Sphingosine-1-phosphate ToremifeneLomustine Camptothecin Sphingosine N,N-dimethyl Trichostatin ALevamisole HCl Monensin Trifluoperazine

AP110 AP111 AP112 AP113 Hydrocortisone Aphidicolin Gallic acid Saikosaponin AMifepristone Chelerythrine chloride Honokiol Saikosaponin B1Potassium Canrenoate Clomiphene citrate Geniposide Saikosaponin B2Prednisolone Na phosphate in 50% DMSO Daunorubicin HCl Geranylgeraniol Saikosaponin CTriamcinolone Doxorubicin HCl Sulfasalazine Saikosaponin DTriamcinolone Acetonide DL, 1'-Acetoxychavicol acetate N-(4-Hydroxyphenyl) retinamide TroglitazoneTriamcinolone Acetonide acetate Bestatine HCl Chloramphenicol Tubeimoside I .1 mmolFinasteride Vinblastine sulfate Naringin Cyclophosphamide

AP114 AP115 AP116 AP117 Hexamethonium bromide hydrate Benzalkonium bromide Clodronate disodium in 50% DMSO CarmustineCalcimycin Stanozolol Phenethyl isothiocyanate TemozolomideMitomycin C Anethole-trithione Phenylbutyl isothiocyanate (-)Epicatechin gallateValinomycin Amlodipine Phenylhexyl isothiocyanate DocetaxelCyclosporin A Amlodipine besylate Phenylpropyl isothiocyanate Vincristine sulfateCyclosporin C Formoterol Fumarate Auraptene 2-HydroxyflutamideCyclosporin D Methimazole Imiquimod 5-FluorouracilCyclosporin H S-Nitrosoglutathione Ticlopidine HCl Acetylsalicyclic acid/Aspirin


AP118 AP119 AP120 AP121 Allyl disulfide Alsterpaullone Arvanil Daunorubicin HClIrinotecan Dihydro-artemisinin Bicalutamide Doxorubicin HClLovastatin Blasticidin S HCl (50% DMSO) Chloramphenicol levo EbselenSimvastatin Cyclosporin B Haloperidol 5-FluorouracilAtorvastatin Kenpaullone Monastrol S-NitrosoglutathioneNimesulide Lonidamine Polydatin PidotimodSecurinine Orlistat Purvalonol A Phorbol-12-myristate-13-acetateAmiodarone HCl

AP122 AP123 CF100 CF101 17-AAG 3-Aminobenzamide Kahweol stearate Kahweol eicosanateN-acetyl-L-cysteine Anisomycin Cafestol stearate Butyric acid sodium saltBetamethasone Camptothecin Kahweol acetate SteriosideCiglitazone Etoposide Cafestol acetate β-NaphthoflavoneDiflubenzuron Huperzine A Cafestol Kahweol LinoleateNidulal Kaempferol Kahweol CaffeinePiperine Pepstatin A Cafestol palmitate 16-OxocafestolVerapamil Scriptaid Caffeic acid 16-Oxokahweol

CL100 CP100 CP101 CP102 Famciclovir R,S-Sulforaphane Thienylethyl isothiocyanate Thienylbutyl isothiocyanateGliclazide R-Sulforaphane Thienylheptyl isothiocyanate Thienyldecyl isothiocyanatePenciclovir S-Sulforaphene Thienylhexyl isothiocyanate Thienyldodecyl isothiocyanateValaciclovir 3-Phenylpropylisothiocyanate Thienylmethyl isothiocyanate Benzyl thiocyanateAcyclovir Phenethyl isothiocyanate Thienylnonanyl isothiocyanate p-XyleneselenocyanateDideoxycytidine 4-Phenylbutylisothiocyanate Thienyloctyl isothiocyanate Benzyl selenocyanateDoxifluridine Phenyl isothiocyanate Thienylpentyl isothiocyanate Taurine Ribavirin Benzyl isothiocyanate Thienylpropyl isothiocyanate Cysteamine hydrochloride

CP103 CP105 CP106 CP107 L Alliin Carbenoxolone Dehydroepiandosterone AlyssinAllyl disulfide Suramin Diclofenac, sodium salt Alyssin sulfoneDiallyl sulfide Theophylline Difluoromethylornithine ErucinDiallyl trisulfide Chlorophyllin 3,3'-Diindolylmethane ErysolinL-Deoxyalliin Chrysin trans-Anethole IberinDipropyldisulfide Biochanin A Chloramphenicol IberverinDipropylsulfide Allopurinol D,L-alpha-Lipoic acid Cheirolin1-Thio-β-D-glucose tetraacetate Melatonin 2-n-Butylthiophene Berteroin

CP108 CP109 CP110 CP111 Acetylsalicylic acid Silymarin Nordihydroguaiaretic Acid Retinol acetate Etoposide Piroxicam Ursodeoxycholic Acid 9-cis Retinoic acidIndole-3-carbinol hydrate Meloxicam Ferulic acid 13-cis Retinoic acid2-5-Dimethylthiopene Miconazole Gallic acid trans Retinoic acid2-n-Octylfuran S-(N-3-Phenylpropylthiocarbamoyl)-L-cysteine Brassinin Retinol2-n-Dodecylfuran Se-methylselenocysteine Phytic Acid Retinyl acetate2-n-Heptylfuran N-Acetyl-L-cysteine Protocatechuic acid Retinyl palmitate2-n-Hexylfuran S-(N-Benzylthiocarbamoyl)-L-cysteine Purpurin N-(4-Carbethoxyphenyl)retinamide

CP112 CP113 CP114 CP115 Methyl caffeate Bergenin Epicatechin 4-Thiouridine3, 4 Dimethyl caffeate 10-hydroxy Camptothecin Epigallocatechin gallate Ftorafur 3, 4 Dimethyl caffeate Andrographolide Catechin 99% Daunorubicin HClCaffeic acid L(+)Selenomethionine Epigallocatechin gallate DextromethorphanPhenethyl caffeate Se-methylseleno-L-cysteine Daidzein Diclazuril3,4 Dimethyl caffeate Benzyl selenocyanate Hesperetin Enrofloxacinβ-Carotene p-Xyleneselenocyanate Green tea polyphenols Vitamin ECanthaxanthin Quinacrine Epicatechin gallate Vitamin D2

CP116 CP120 CP121 CP122 S-Hexylglutathione Calcium folinate Ifosfamide L-Lysine in 50% DMSODL-Homocysteine thiolactone HCl Carnosic acid Ipriflavone 7-Methyl-6-mercaptopurineHomoharringtonin Thiamphenicol Palmitate Bilobalide 9-Methyl-6-mercaptopurineN-(4-Hydroxyphenyl)retinamide Thiamphenicol Glycinate Ketoconazole Megestrol AcetateHypocrellin A Ciprofloxacin Levonorgestrel 6-Mercaptopurine monohydrate Hypocrellin B Clindamycin hydrochloride Lomustine MethotrexateIdoxuridine Clindamycin phosphate Lycopene MESNA Ketotifen Fumarate Coumestrol Trimebutine Maleate α-Methylbenzyl isothiocyanate


CP123 CP124 CP125 CP126 Bleomycin sulfate R(-)-α-Methylbenzyl isothiocyanate Naproxen Bestatine HydrochlorideBrassinin S(+)-α-Methylbenzyl isothiocyanate Nigrin 1,4-Benzoquinone5-Bromo-2'-deoxyuridine Metoprolol Nitroso(acetoxymethyl)methylamine Berberine hydrochloride hydrateNeomycin sulfate Mitoxantrone Clindamycin HCl Bis(3,5-dibromosalicyl) fumarate3-tert-Butyl-5-methoxy-1, 2-quinone Molsidomine Norfloxacin Bis(3,5-dibromosalicyl) succinaten-Butyric acid Myricetin Ochratoxin A Bis(salicyl) fumarateButyric Acid Sodium Salt Hydroquinone Pamidronate Disodium Bisazir Bleomycin A5 HCl Sulbactam Palmatine

CP127 CP128 CP129 CP130 N-Acetyl-L-Cysteine 4-Aminophenylphosphate monosodium Selenomethionine Phenylbutyl isothiocyanateActinomycin / Dactinomycin Artemisinin (Qinghaosu) Penciclovir CurcuminAflatoxin B1 11H-Benzo[a]fluorene Thienyloctyl isothiocyanate IndomethacinCyclosporin A Celecoxib Thalidomide ProgesteroneL(+)Alliin S-(N-Benzylthiocarbamoyl)-L-cysteine Thapsigarin ResiniferatoxinAlloxan Monohydrate L-(+)-Selenomethionine Theophylline ROPAAlbendazol Thioctic Acid Thiamphenicol Palmitate Rimantadine HClRisedronate Tobramycin Sulfate in 50% DMSO Lorglumide Rutin

CP131 CP132 CP133 CP134 Actinomycin Methotrexate 11H-Benzo[a]fluorene NabumetoneLevamisole 4-Aminophenylphosphate Megestrol acetate NeostigmineLevonorgestrel Aminoglutethimide Chlorpromazine Trimebutine MaleateLeuprolide Antipain Chymostatin CholecalciferolCarboplatin Artemisinin Chloroadenosine HomoharringtoninCalcimycin L(+)Ascorbic Acid Rimantadine HCl TunicamycinCaffeine Biopterin Lactulose Uracil3-Aminobenzamide Brefeldin A Danazol Verapamil

CP135 CP136 CP137 CP138 2-tert-Butyl-4-hydroxyanisole Toremifene Cromolyn Sodium Cyclohexamide3-tert-Butyl-4-hydroxyanisole Tranilast Curcumin Cytarabine4-tert-Butyl-5-methoxy-catechol Tranylcypromine Harringtonin Geranylgeraniol3-tert-Butyl-5-methoxy-1, 2-quinone Trichostatin A Disulfiram Acyclovir4-tert-Butyl-5-methoxy-1, 2-quinone Roscovitine Diphenhydramine Clindamycin HCl2,5-Di-tert-butyl-4-hydroxyanisole Sphingosine Doxycycline EsculetinButylated Hydroxyanisole Sphingosine-1-phosphate S-Hexylglutathione EsculinButylated hydroxytoluene Melphalan Ethoxyquin

CP139 CP140 CP141 CP142 Camptothecin Fluocinolone Acetonide Hydroxyurea NerolidolCamptothecin, 10-hydroxy Folic Acid Glycyrrhetinic Acid TetracyclineIrinotecan Ftorafur Palmitoyl-DL-carnitine S-NitrosoglutathioneTopotecan Ganciclovir Palmitoyl-L-carnitine NimesulideIsorhamnetin Glucaric Acid Idoxuridine NonoxynolKainic Acid Puromycin Inositol NorepinephrineOxaliplatin Phenylbutazone Ionomycin 1-Thio-β-D-glucose tetraacetateDL-Homocysteine thiolactone HCl Phenylbutyrate Isopropyl Thiogalactoside Riboflavin

CP143 CP144 CP145 CP146 Sulindac 9-cis Retinoic acid 4'-Bromoflavone AurapteneSulindac sulfide Calcitriol Bezafibrate GeniposideSulindac sulfone D-Limonene Honokiol LimoninSedanolide Nicotinamide Magnolol Naringenin3-tert-Butyl-5-methoxy-catechol trans-Retinoic acid Flutamide Nomilin6-Aminocaproic acid in 50% DMSO Vitamin A Ifosfamide Anethole-trithioneChlorogenic acid Vitamin B12 Tanshinones I OltiprazMethylprednisolone Tanshinones IIA DL-1'-Acetoxychavicol acetate

CP147 CP148 CP149 CP150 Chalcone 18 b-Glycyrrhetinic acid Dexamethasone AmpiroxicamDiosmin Carveol Exemestane DiflunisalGenistein Perillyl alcohol Medroxyprogesterone 17-acetate FlurbiprofenHesperidin Rubescensin A Melatonin IbuprofenIcariin Tubeimoside I .1 mmol Tamoxifen citrate S(+) IbuprofenKaempferol Ascorbyl palmitate Lisinopril KetoprofenQuercetin dihydrate Troglitazone Coumarin Mefenamic acidSilybin Tenoxicam


CP151 NA100 NA101 NA102 β-Naphthoflavone Flurbiprofen Diclofenac FenoprofenEllagic acid Ketoprofen Diflunisal IbuprofenPhenethyl glucosinolate Piroxicam D-Naproxen S(+) IbuprofenResveratrol Indomethacin DL-Naproxen FlurbiprofenD-Naproxen Sulindac Flufenamic acid KetoprofenD,L-Naproxen Sulindac sulfone Mefenamic acid TenoxicamTranilast Sulindac sulfide Phenylbutazone NabumetoneTheophylline D,L-Naproxen Sulfasalazine Meloxicam

NA103 NA105 NP100 NP101 Acemetacin Anisodamine Artemisinin (Qinghaosu) BrassininAcetyl salicyclic acid Dantrolene Sodium Ascorbic acid CafestolFenbufen Desloratadine Bergenin Cafestol palmitateNiflumic acid 4-Dimethylaminopyridine Berberine HCl hydrate CamptothecinNimesulide Letrozole Biochanin A Carnosic acidTolfenamic acid Matrine Bleomycin sulfate CatechinTolmetin sodium Salicin Thioctic Acid Chalcone 97%

NP102 NP103 NP104 NP105 Chrysin Epigallocatechin gallate Ginsenosides Phytic AcidL-Deoxyalliin Epirubicin Ginkgolic acid Protocatechuic acidDiallyl sulfide, 97% Etoposide Ginkgolide A PuerarinDiallyl trisulfide Farnesol Ginkgolide B Quercetin dihydrateDipropyl sulfide Flavanone Ginkgolide C ResiniferatoxinDiosmin Folic Acid Ginkgolides RiboflavinDoxorubicin Hydrochloride Folinic Acid in 50% DMSO Indole-3-carbinol hydrate Rosmarinic AcidEllagic acid Galactosamine Bilobalide Sedanolide

NP106 NP107 NP108 NP109 Silybin Ginsenoside F1 Ginsenoside Re PanaxatriolSinomenine Ginsenoside F2 Ginsenoside Rg1 PanaxadiolL-Sulforaphane, 96% Ginsenoside F3 Ginsenoside Rg2 ProtopanaxadiolSynephrine Ginsenoside Rb1 Ginsenoside Rg3 ProtopanaxatriolTanshinone IIA Ginsenoside Rb2 Ginsenoside Rh1 Pseudoginsenoside F11Vinblastine sulfate Ginsenoside Rb3 Ginsenoside Rh2 Schisantherin AVincristine sulfate Ginsenoside Rc Ginsenoside X R(+) Schisandrin A

Ginsenoside Rd Notoginsenoside R1 S(-) Schisandrin B

NP110 NP112 NP113 NP114 Cryptotanshinone 5,6-Dehydrokawain Auraptene 1-Isothiocyanato-7-(methylsulfinyl)-heptane

Dihydrotanshinone 7,8-Dihydrokawain Kawain AlyssinHonokiol Dihydromethysticin D-Limonene Benzyl isothiocyanateMagnolol Kahweol Limonin IberinTanshinones I Kahweol palmitate Limonin glucoside Phenethyl isothiocyanateTanshinones IIA Methoxyyangonin Naringin R,S-SulforaphaneEuphorbiasteroid Methysticin Naringenin S-SulforaphaneAsiatic acid Paeonol Nomilin S-Sulforaphene

NP115 NP116 NP117 NP118Catharanthine base Aconitine Daidzein BaicalinCatharanthine sulfate Caffeic acid Genistein Canthaxanthin .5 mmolCatharanthine tartrate Cepharanthine Icariin CapsaicinColchicine D,L-Tetrahydropalmatine sulfate Luteolin CapsanthinVindesine sulfate Staurosporine Myricetin Lycopene .5 mmolVindoline Teniposide Paeoniflorin Green Tea PolyphenolsHarringtonin Kainic Acid Silymarin Glucaric acidHomoharringtonin 18 β-Glycyrrhetinic acid

NP119 NP120 NP121 NP122 Aristolochic acid A Allyl disulfide Madecassic acid IsorhamnetinAristolochic acid C Brefeldin A Myristicin Kaempferol7-Hydroxyaristolochic acid A Caffeine Paclitaxel, (Taxol) ResveratrolAndrographolide Vitamin B12 Perillyl alcohol Rutin HydrateAndrographolide, dehydro- Hypocrellin A Rubescensin A Nordihydroguiaretic acidAndrographolide, deoxy- Hypocrellin B Saikosaponin A Geniposideα-Santonin Triptolide Saikosaponin C Phenethyl caffeateCarveol Glycyrrhizic acid Saikosaponin D Phenethyl glucosinolate


NP123 NP124 NP125 NP126Actinomycin Anisomycin Erythromycin Amastatin HClBleomycin A5 Bafilomycin B1 Erythromycin Ethylsuccinate Artemether Caerulomycin A Kanamycin A (50% DMSO) Paromomycin Sulphate (50% DMSO) ArtesuanateColistin Sulphate Kanamycin B (50% DMSO) β-Rubromycin CarnosolIkarugamycin Kendomycin Spiramycin ChartreusinPodophyllotoxin Natamycin Spiramycin Embronate Huperzine AAsiaticoside Spiramycin Spiramycin Hexanedioate Pepstatin APhorbol-12-myristate-13 acetate Polydatin

NP127 ST100 ST101 ST102 Amygdalin Simvastatin Phorbol 12,13-dibutyrate Chelerythrne ChlorideMatrine Pravastatin Phorbol 12-Myristate 13- Acetate ForskolinNidulal Mevinolin 4α-Phorbol 12-myristate 13-acetate H7Phallacidin Pravastatin Roscovitine H8Phalloidin Mevastatin Thapsigargin H89Piperine Simvastatin Tyrphostin A25 Lavendustin ASalicin Fluvastatin Calyculin A Okadaic Acid

Tyrphostin AG490 Ceramide C16

ST103 ST104 ST105 ST106 Ginkgolide A L-Carnitine HCl Lappaconitine GABAGinkgolide B L-Carnitine tartrate Nefazodone Palmitoyl-DL-carnitine chlorideGinkgolide C L-Cystine Tramadol HCl Palmitoyl-L-carnitine chlorideGinkgolide AB N-Acetyl-L-Cysteine Matrine RibavirinLeflunomide Naphazoline HCl Flufenamic acid StaurosporineLisinopril Oxymetazoline HCl Irsogladine maleate GlimepirideDaunorubicin HCl Lagochiline Pantoprazole GlipizideEpirubicin HCl Estradiol Ivermectin

ST107 ST108 ST109 ST110 Prednisone D-Sphingosine 7-Nitroindazole (-) EpinephrinePrednisone acetate Sphingosine 1-phosphate Biopterin Chenodeoxycholic acidResiniferatoxin Suramin hexasodium salt D,L-1'-Acetoxychavicol acetate Copper bis-3,5-diisopropylsalicylateResiniferonil-9,13,14-orthophenyl Saikosaponin A Galanthamine hydrobromide ImiquimodMemantine HCl Saikosaponin B1 Isatin MagnololNimodipine Saikosaponin B2 Salsoline OlomoucineFluoxetine HCl Saikosaponin C Ochratoxin A Trichostatin A

Saikosaponin D Rapamycin Etoposide

ST111 ST112 ST113 ST114 Anisomycin Anisodamine Amastatin HCl 17-AAGArvanil Citalopram HBr Ambroxol HCl D-Cycloserine (50% DMSO)Blasticidin S HCl (50% DMSO) Clozapine Caffeine FluphenazineEbselen Huperzine A Dantrolene Sodium Hydroxyzine DiHClHaloperidol Octopamine HCl Kenpaullone LevosimendenNigericin Pyriproxyfen Scriptaid Octopamine HClOsthole Ropinirole TDZD-8 Pizotyline malate

TT100 TT101 TT102 XX100 Baccatin III 2'-Acetyltaxol Taxol C 11,12-DimethoxydihydrokawainPaclitaxel Taxol side chain Methyl Ester Xylosyltaxol C 11-Methoxyyangonin7-epi-Taxol Baccatin I 1-hydroxy Xylosyltaxol Dihydromyristicin2'-Acetyltaxol 10-Deacetylbaccatin-III 10-Deactyl taxol Flavokawain ACephalomannine 7-epi-10-Deacetyltaxol 10-Deactyl-7-xylosyltaxol Flavokawain B13-Acetyl-9-dihydrobaccatin-III Taxol side chain Diol 10-Deactyltaxol B 1-ITC-6-(methylsulfenyl)-hexane7-epi-10-Deacetyltaxol Paclitaxel 10-Deactyltaxol C 1-ITC-6-(methylsulfinyl)-hexane

2',7-bis Acetyltaxol Acarbose

XX101 XX102 XX103 XX104 Levodopa Carbimazole 17α-Hydroxyprogesterone Levofloxacin free baseMethyldopa Fenbendazole 6-Phenyl-hex-3,5-dien-2-one Moxifloxacin HCl4'-Demethylepipodophyllotoxin Letrozole Azaperone Norfloxacin nicotinateAminophylline anhydrous Pantoprazole sodium β-Ecdysone Ofloxacin HClDoxofylline Ricobendazole Buspirone HCl IndapamideRaloxifene HCl Tenatoprazole Canrenone FormononetinSulfadimethoxine Tinidazole Ceftriaxone sodium GabapentinTazobactum Venlafaxine HCl Idebenone Pravastatin lactone


XX105 XX106 XX107 XX108 5-Methoxyindole Norethindrone 2',3'-Dideoxyinosine L-(+) Lysine monohydrate 50% DMSODipyridamole Spironolactone Anabasine HCl L-Arginine in 50% DMSOAcipimox Tibolone Azelastine HCl L-Arginine monohydrochlorideTelmisartan Zopiclone Bromhexine HCl L-Glutamine in 50% DMSO5-Aminosalicylic acid Dibenzoylmethane Carbamazepine L-Ornithine HClBenzo[a]pyrene Formestane Tropicamide L-TheanineOxytetracycline Ondansetron HCl Rebamipide Loratadine

Fenoldopam mesylate Glycidamide Naphazoline nitrate

XX109 XX110 XX111 XX112 Desoxypeganine HCl Adenosine Triphosphate disodium Carvedilol RacecadotrilDopamine HCl Aniracetam Clopidogrel sulfate RamiprilFamotidine Paroxetine HCl Clopidol ToltrazurilGlucosamine HCl Salsolidine Iohexol UradipilTranylcypromine Sibutramine HCl monohydrate L-Alaninol Uradipil HClHypoxanthine Vinorelbine tartrate L-Phenylalaninol Timolol maleatePhentolamine mesylate Ranitidine HCl Salbutamol free base TriadimenolPhentolamine HCl Roxatidine acetate HCl Salbutamol sulphate Vecuronium bromide

XX113 XX114 XX115 XX116 Enalapril Biotin Estriol AbamectinEnalapril maleate Doxazosin mesylate Estrone CuelureEnalaprilat Guaifenesin Ethisterone Emamectin B1 BenzoateFlumazenil Heparin sodium in 50% DMSO Etidronate disodium in 50% DMSO EprinomectinGemfibrozil Methylhesperidin Tropisetron HCl Emamectin B1 BenzoateMinoxidil Tylosin phosphate Baclofen SulfluramidMyclobutanil Tylosin tartrate Atracurium besylate ThiabendazoleQuinapril HCl Aspartame

XX117 Forchlorfenuron IsoniazidNeopterineNizatidineRisedronic acidTrimebutine baseTriflumuron


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CategorizedSpecialty

Chemicals

888-558-5227

The following are lists of ourspecialty chemicals which have categorized

according current research

AngiogenesisA0099A1865A4944A5228A5230A6017A6132A6234A6979A6982A4944C0275C3250D1693D3221D3322D4802D5709D5898E6234F8048H9611I7074L0107L1682L3374M1613M3353O1078P3348R0212T1670T1849T1854T2800T7134V0376W3576

A-779AeroplysininAmlexanoxAngiogeninAngiostatinApelin-13, human, bovineApicidinApigeninDihydroartemisininArtesunateAmlexanoxCastanospermineCimetidineDexamethasoneDifluoromethylornithineDiflunisal17-DMAGDocetaxelDoxycycline MonohydrateEpigallocatechin gallateFumagillinHydrocortisoneIrsogladine maleateLactacystinLevamisole HydrochlorideLisinoprilMedroxyprogesterone 17-Acetate Minocycline HClOctreotide AcetatePimecrolimusRadiciolTerazosin Hydrochloride DihydrateTemozolomideTenofovir MonohydateThalidomidetrans-3,4’,5-Trimethoxy-stilbeneVatalanib DihydrochlorideWithaferin A


AntimicrobialsA0977A0978A1096A1318 A3212 A4400 A4443A4444 A4606A4675A4678A4802A5033A5034A5039A5056A5057A5130A5132A5160A5162A5373A6229A6264A6804A6970A6982A7208A7333A9834A9978B0025B0026B0108B0109B1545B1668B1769B1874B3203B3320B3577B4402B4517B4518B6816B6935B8278C0016C0168C0246C0267C0268C0275C0476C1609C1620C1624C1627C1629C1630

Actinomycin / DactinomycinActinoninAcycloguanosine/AcyclovirAdenine3’-Azido-3’-deoxythymidineAlamethicinL(+)Alliin / 3-(2-Propenylsulfinyl) alanineL(±) AlliinAlbendazoleAlternariolAlternariol-9-methyl etherAmantadine Hydrochloride4-Aminosalicylic acid4-Aminosalicylic acid sodium dihydrateAmitrazAmorolfine HydrochlorideAmoxicillinAmphotericin BAmikacin DisulfateAmpicillin TrihydrateAmprolium HydrochlorideAnisomycinAphidicolinApramycinArbutinArtemetherArtesunateAscomycinAsiaticosideAzithromycinAztreonamBafilomycin A1 Bafilomycin B1BactenecinBakuchiolBenzalkonium BromideBerteroin, 97%BergeninBestatin HClBiapenemBifonazoleBitertanolBlasticidin S HClBleomycin A5 HClBleomycin sulfateBrefeldin A BrivudineButoconazole NitrateCaerulomycin ACarbadoxCalcimycinCarnosolCarbadoxCastanospermineCB-THCecropin BCeftiofur HClCefuroxime Sodium SaltCefaclor, MonohydrateCefoperazone acidCefoperazone Sodium

C1632C1633C1635C1637C1869C1878C2803C2844C2845C2950C2951C2969C2970C3208C3262C3263C4502C4510C4532C4533C4534C4535C4656C4657C4756C4758C5647C6956C7097C9610C9611C9612C9613C9614C9615C9670C9863D0182D0353D1748D1768D3223D3320D3330D3353D5794D5869D5897D5898E0073E5358E5369E5576E6235E6259E6470E6994E6995E6996E7228E7230

Cefotoxime AcidCefotaxime sodiumCeftazidimeCeftriaxone sodiumCeruleninCetrimideChartreusinChloramphenicolChloramphenicol LevoChloroquine phosphateChlortetracycline HClChromomycin A3ChrysophanolCiclopirox OlamineCiprofloxacinCiprofloxacin HClClarithromycinClimbazoleClindamycin HClClindamycin phosphateClindamycin Palmitate HClClinafloxacin HClClopidolClotrimazoleCloxacillin sodiumClosantelColistin sulphateCrotamitonCryptotanshinoneD-CylcoserineCyclosporin ACyclosporin C Cyclosporin D Cyclosporin H Cyclosporin B CyromazineCyproconazoleDaunorubicin HCl / DaunomycinDanofloxacinDemeclocycline HClDermaseptin IDifloxacin HClDifenoconazoleDihydrotanshinoneDiminazene AceturateDoxorubicin HClDoripenem HydrateDoxycycline HyclateDoxycycline MonohydrateEbselenEnoxacinEnrofloxacinEntecavirEpirubicin HClEpoxiconazoleEprinomectinErythromycinErythromycin EthylsuccinateErythromycin thiocyanateEthacridine Lactate MonohydrateEthambutol


AntimicrobialsE8419F0048F1650F1854F1895F4556F4679F4682F4881F4883F5873F5874F8048F8272G0145G0152G0278G1646G1658G1849G4434G4796H1992H3273H5654H9662H9715H9861I1257I4000I4934I5034I5215I5313I7341I7870I8616K0053K0054K1653L0209L0254L0350L1761L1785L1786L3453L3454L5749L5862M0125M0255M1605M1770M1826M1977M3309M3310M3353M3598M5753

EverolimusFamciclovir FenbendazoleFenticonazoleFexofenadine HydrochlorideFlorfenicolFlubendazoleFluconazoleFlumequine SodiumFlutriafolFoscarnet sodiumFosfomycin CalciumFumagillinFusarenon XGallic acid / 3,4,5-Trihydroxybenzoic acidGanciclovir GatifloxacinGeldanamycinGentamycin sulfateGemifloxacin MesylateGliotoxinGlycerol MonolaurateHexaconazoleHistatin 5HonokiolHypocrellin BHydroxyureaHypericinIdoxuridine / (+)-5-Iodo-2’-deoxyuridineIkarugamycinImipenemImiquimodIndolicidinIndinavir SulfateIsoniazidItraconazoleIvermectinKanamycin AKanamycin BKendomycinLactoferrin, BovineLansoprazoleLamivudineLeptomycin BLevofloxacin Free BaseLevofloxacin HClLinezolidLincomycin HClLomefloxacin HClLopinavirMagnololManzamine AMebendazolMeropenem Sodium CarbonateMeglumineMetronidazoleMiconazole. Miconazole NitrateMinocycline HClMizoribine HydrobromideMonensin Sodium

M5794M9608M9710N0075N0114N1656N1755N1976N3323N3520N5768N5769N9874O2144O2145O2146O4417O4531O4532O4533O4578O6805O6953O7218O9234O9302O9322O9334O9396O9397O9458P0268P0278P0370P0398P1622P1852P1853P2445P2845P2995P3462P3463P5885P6959P7033P7082P7103P7358P7359P9668P9671P9767R0161R2710R2711R2712R2713R2714R2810R2811

Moxifloxacin HClMyclobutanilMycophenolic acidNatamycinNadifloxacinD(+)-NeopterinNeomycin SulfateNetilmicin SulfateNifuratelNifursolNorfloxacinNorfloxacin NicotinateNystatinOfloxacinOfloxacin HClR-(+)-OfloxacinOleanolic acidOligomycin AOligomycin BOligomycinOltiprazOrbifloxacinOrnidazoleOseltamivir PhosphateOxiconazole NitrateOxacillin Sodium MonohydrateOxfendazoleOxibendazoleOxytetracyclineOxytetracycline HClOxolinic AcidParasin IPatulinParomomycin SulphatePazufloxacin MesylatePefloxacine MesylatePenicillin G ProcainePenicillin V PotassiumPGLaPhleomycinPhyscionPiperacillin Piperacillin sodium Povidone iodineProthionamidePrimaquine phosphatePrulifloxacinPraziquantelPsoralen (Ficusin)PsoralidinPyrantel PamoatePyrazinamidePyriproxyfenRapamycinRecombinant Mutli-epitope Chimeric HCV antigenRecombinant HCV-Core antigensRecombinant HCV-NS3 antigensRecombinant HCV-NS4 antigensRecomvinant HCV-NS5 antigensRecombinant Multi-epitope Chimeric HIV antigen 1Recombinant HIV-1gp-41


AntimicrobialsR2812R2813R2814R2815R2816R3010R3011R3012R3013R3014R3220R3221R3222R3249R3310R3321R3577R5878R5992R8122R8207S0053S0170S1810S3033S6000S6018S6232S6233S6234S7769S8144S8169S8248T1672T1679T1844T2932T2935T3134T3324T3357T5672T7034T9945U7354V0145V0244V5886Z0252

Recombinant HIV-1gp-120Recombinant HIV-1p24Recombinant HIV-1p31Recombinant HIV-1”O” group consensusRecombinant HIB-2 gp36Recombinant Tp-chimeric proteinRecombinant TpN 15 proteinRecombinant TpN 17 proteinRecombinant TpN44.50 proteinRecombinant TpN 47 proteinRifampinRifamycin SV-3 formylRifamycin SV monosodium saltRimantadine HClRicobendazoleRifaximinRitonavirRotenoneRoxithromycinRufloxacin HClb-Rubromycina-SantoninSarafloxacin HClSecnidazoleShikimic acidSparfloxacinSpectinomycin HClSpiramycinSpiramycin HexanedioateSpiramycin EmbonateStreptomycin sulfateSulfadoxineSuramin hexasodium saltSulfamethoxazoleTerbinafine HClTetracycline HClTelbivudineThiamphenicol Glycinate HydrochlorideThiamphenicolThiostreptonTigecyclineTioconazoleTosufloxacin TosylateTrimethoprimTylosin tartrateUsnic acidValinomycinValganciclovir HydrochlorideVoriconazoleZanamivir


Antineoplastics/AntitumorA0025A0817A0820A0823A0902A0910A0917A0934A0978A1865A4402A4438A4445A4521A4578A4940A5072A5130A5193A5230A5302A6368A6823A6970A6978A6979A7460A7658A9602A9603B0025B1853B1855B1870B1874B1898B3209B3210B4517B4518B5871B6816B6856B6998B7973B8071B8072B8075C0147C0150C0152C0154C0155C0156C0171C0173C0174C0221C0260C0266C0277

17-AAGD,L-1’-Acetoxychavicol AcetateN-Acetyl-S-(N’-benzylthiocarbamoyl)-L-cysteineN-Acetyl-S-(N’-methylthiocarbamoyl)-L-cysteineN-Acetyl-S-(N’-phenylhexyllthiocarbamoyl)-L-cysteineN-Acetyl-S-(N’-phenylthiocarbamoyl)-L-cysteine1’ S-1’-Acetoxychavicol AcetateAcivicinActinoninAeroplysininL-AlaninolAllatostatin IAllopurinolAlfacalcidolAltretamine6-AminonicotinamideAmsacrineAmphotericin BAmygdalinAngiostatinAnastrozoleAprepitantArgatrobanArtemetherArtemisinin (Qinghaosu)DihydroartemisininAsparaginaseAtorvastatinAzacitidine5-Aza-2’-deoxycytidine (Decitabine)Balfilomycin A11,4-BenzoquinoneO6-BenzylguanineBerberine HCl hydrateBestatin HClBezafibrateBicalutamideR-BicalutamideBleomycin A5 HClBleomycin sulfateBortezomibBrefeldin A5-Bromo-2’-deoxyuridineBryostatin 1Busulfan / 1,4-Butanediol dimethanesulfonate3-tert-Butyl-4-hydroxyanisole, 99%3-tert-Butyl-5-methoxy-catechol4-tert-Butyl-5-methoxy-1,2-quinoneCalcium folinate, pentahydrateCamptothecinCamptothecin, 9-aminoCamptothecin, 7-ethyl-10-hydroxy (SN-38)Camptothecin, 10-hydroxyCamptothecin, 9-nitro-20(S)CarboplatinCarmustineCarmofurCaffeineCapsanthinCapsaicin, naturalCatechins, 90%

C0344C0346C0368C0376C0377C0378C1613C1648C1649C1650C1869C1876C2803C2942C2946C2949C2950C2969C3250C3260C3374C4557C4646C5773C5782C5968C9673C9709C9710D0010D0011D0182D0253D0375D1749D1859D1849D3221D3228D3232D3261D3262D3304D3362D4802D5692D5794D5992D6958E0813E5456E5477E6235E6846E7310E7329E7378E7556E7668F0268F1655

Calphostin CCalyculin ACarveolCatharanthine baseCatharanthine sulfateCatharanthine tartrateCediraniba-Cembrenediolb-Cembrenediolb-Cembrenediol Methyl EsterCeruleninCetirizine DihydrochlorideChartreusinMechlorethamine HClChlorambucilChlorpheniramine MaleateChloroquine phosphateChromomycin A3CimetidineCiprofibrateCisplatinClofibrateClofarabineCortistatin-14CoumarinCordycepinCysteamine HClCycloheximideCyclopamin3H-1,2-dithiole-3-thioneDacarbazineDaunorubicin HClDanazolDasatinib MonohydrateDemecolcine2-Deoxy-D-Glucose4’-DemethylepipodophyllotoxinDifluoromethylornithineDihydromyristicin3,3’-DiindolylmethaneDipropyl disulfideDipropyl sulfideDibenzoylmethane, 98%Dipyridamole17-DMAGDoxifluridineDoxorubicin HClDoxapram Hydrochloride HydrateDroloxifene citrateEcdysteroneEnocitabineEntinostatEpirubicin HClErlotinib MonohydrochlorideEsculinEthoxyquinEstroneEtodolacEtretinateFarnesolFenoprofen


Antineoplastics/AntitumorF3454F4480F4501F4557F4582F4781F4782E5477F5745F5976E7578E7579F7657F8048F8147G0152G0181G0182G1646G1650G1721G3351G3352G3353G3354G3355G3356G3357G3358G3359G3454G3455G3456G3457G3458G3459G3460G3461G3552G3553G3554G3556G3557G3558G4597G5857G6802H0169H1862H5750H9611H9615H9618H9715H9718H9814H9815H9861I0502I1257I1400

Fingolimod HCl5-FlurorouracilFlavanoneFloxuridineFluocinolone AcetonideFludarabineFludarabine PhosphateEntinostatFolic AcidFotemustineEstramustineEstramustine Phosphate SodiumFtorafurFumagillinFulvestrantGanciclovirGastrin Releasing Peptide, humanGastrin Releasing Peptide, porcineGeldanamycinGeniposideGefitinibGinkgolic acids MixtureGinkgolic acid (13:0)Ginkgolic acidGinkgolide AGinkgolide BGinkgolide ABGinkgolide CGinkgolidesGinkgolide JGinsenoside Rb1Ginsenoside RcGinsenoside RdGinsenoside ReGinsenoside Rg1Ginsenoside Rg2Ginsenoside F1Ginsenoside F220(S)-Ginsenoside Rg3Ginsenoside Rb2Ginsenoside Rb320(R)-Ginsenoside Rg3Ginsenoside Rh120(R)-Ginsenoside Rh218 b-Glycyrrhetinic AcidGossypol-acetic AcidGranisetron HClHarringtoninHeptaplatinHomoharringtoninHydrocortisone17a-Hydroxyprogesterone CaproateHydroquinoneHydroxyurea2-Hydroxy-flutamide25-Hydroxyvitamin D225-Hydroxyvitamin D3HypericinIbandronateIdoxuridineIdarubicin HCl

I2056I5354I5753I7357K1653K1676K7602L0109L0211L0360L1682L1761L1878L3374L5648L5658L5750M0374M1560M1613M1626M1669M1676M1685M1746M1774M1875M1878M1975M2076M3377M3379M3476M3576M5876M9710N0068N0075N0163N0212N1744N3452N5409N5669N5778O1078O4402O4417O4578O9201O9702P0397P1200P1202P2508P2512P2513P2514P2516P2522P2816

IfosfamideInaparibIonomycin calciumIsorhamnetinKendomycinKetoconazoleKT5823LactalbuminLactuloseLapatinib DiosylateLevamisole HClLeptomycin BLetrozoleLisinoprilLomustineLonidamineLomeguatribMasitinibMethyl caffeateMedroxyprogesterone 17-acetateMegestrol Acetate6-Mercaptopurine monohydrateMethotrexateMevastatinMelphalanMESNAS-(N-Methylsulfinylbutylthiocarbamoyl)-glutathione16-O-MethylkahweolS-(N-Methylthiocarbamoyl)-L-cysteineMetformin HydrochlorideMitomycin CMitoxantrone DihydrochlorideMithramycinMitotaneMotesanibMycophenolic acidNaringeninNaringin2-(1,8-Naphthyridin-2-ly)phenolNedaplatinNelarabineNimustine HClNocodazoleNordihydroguaiaretic acidNotoginsenoside R1Octreotide AcetateOlaparibOleanolic acidOltiprazOxaliplatinOzagrel HydrochloridePazopanibPD184352PD325901Phenethyl isothiocyanateS-(N-Phenethylthiocarbamoyl)-L-CysteinePhenyl isothiocyanateS-(N-Phenylbutylthiocarbamoyl)-GlutathioneS-(N-Phenylbutylthiocarbamoyl)-L-CysteineS-(N-Phenylthiocarbamoyl)-GlutathioneS-(N-3-Phenylpropylthiocarbamoyl)-L-cysteine


Antineoplastics/AntitumorP2919P2922P2995P2997P3348P3568P3592P5712P6801P6858P7020P7021P7318P7359P8167P8382P9768R0248R1776R1985R2512R3205R3312R8206S0278S1069S3449S6130S7870S8147S8169S8245T0090T0091T0093T0094T0096T0097T0098T0099T0100T0101T0102T0103T0104T0105T0106T0107T0108T0110T0114T0115T0116T0119T0152T0153T0154T0249T1652T1654T1670

L-PhenylalaninolPhenylhexyl isothiocyanatePhyscionPhytic AcidPimecrolimusPiraubicinPixantrone DimaleatePodophyllotoxinPravastatin SodiumProcarbazine HClPrednisonePrednisone AcetatePseudoginsenoside F11PsoralidinPuromycin aminonucleosidePuupehenonePyronaridine TetraphosphateRamatrobanResveratrolReveromycin ARGDRibavirinRidaifen DihydrochlorideRubescensin ASatraplatinScriptaidSimvastatinSphingosine-1-phosphateStreptozocinSulindac sulfideSuramin hexasodium saltSulfadiazine7-(triethylsilyl)-Baccatin III7-(triethylsilyl)-10-deacetyl Baccatin III2’-Acetyltaxol2’,7-bis AcetyltaxolCephalomannine10-Deacetyltaxol-B10-Deacetyltaxol-C10-Deacetylbaccatin-III10-Deacetyltaxol7-epi-10-Deacetyltaxol7-epi-TaxolTaxol-side chain diolTaxol-side chain methyl esterTaxol CXylosyltaxol, 90%Xylosyltaxol C, 90%10-Deacetyl-7-xylosyltaxol, 90%Taxane Standard MixtureTaxinine MTaxol side chain acid2”,3”-DihydrocephalomannineTaxol-side chain b-lactamTandutinnibTanshinone ITanshinone IIATamibaroteneTeniposideTenoxicamTerazosin HCl Dihydrate

T1849T1952T2528T2800T2816T2817T2835T3468T5761T5769T7036T8004T8020U0618U7354V0160V1745V1868V3251V3252V3253V3345V3354V3355V3454V3479V5254V5734X1854

TemozolomideTenuazonic acidS-(N-Thienylmethylthiocarbamoyl)-L-CysteineThalidomideL-TheanineTheophylline6-ThioguanineTirapazamineTopotecan HClToremifene BaseTriptorelin, [DTrp6]-LH-RH, AmideTubeimoside ITuftsinUbenimexUsnic acidRC-160 (Vapreotide)VeliparibVeratramineVinorelbine baseVinorelbine DitartrateVinblastine sulfateVildagliptinVindesine sulfateVindolineVinleurosine sulfateVitamin K3Vincristine sulfateVorinostatp-Xyleneselenocyanate, 99%


AntioxidantsA7210A7309B1753B1769B1853B1898B3358B3458B7977B8070B8071B8073B8074B8174C0121C0168C0262C0263C0264C0265C0267C0269C2943C2944C2968C8069D0010D0255D3331D3420D3431D3575E0073E4444E6231E6232E6233E6234E6814E7309E7310E7329E7433F1669F4482F5770G0243G0245G4532H9611H9612I1418I7302L3561L8377L9609M1745M1976N0068N0069N0114

L(+)-Ascorbic acidAscorbyl palmitateBenfotiamineBergenin1,4-BenzoquinoneBezafibrateBiochanin ABiopterinButylated hydroxytoluene / BHT2-tert-Butyl-4-hydroxyanisole, 99%3-tert-Butyl-4-hydroxyanisole, 99%4-tert-Butyl-5-methoxy-catechol3-tert-Butyl-5-metoxy-1, 2-quinoneButylated HydroxyanisoleCaffeic acidCanthaxanthinL-CarnitineL-Carnitine HClL-Carnitine tartrateCarnosic acidCarnosolb-CaroteneChlorogenic acid (from Eucommia Bark)Chlorogenic acid (from Flos lonicerae)ChrysinCurcumin3H-1,2-dithiole-3-thioneDantrolene Sodiuma, b-Dihydryoresveratrol3,4 Difluorobenzocurcumin3,4-Dihydroxyphenyl Ethanol2,5-Di-tert-butyl-4-hydroxyanisoleEbselenEllagic acid(-)Epicatechin(-)Epicatechin gallate(-)EpigallocatechinEpigallocatechin gallateErdosteineEsculetinEsculinEthoxyquinEtidronate DisodiumFerulic acidFluvastatin SodiumFormononetin(-)-GallocatechinGallocatechin GallateGliclazideHydrocortisoneHydrocortisone 21-acetateIdebenoneIsatinD,L-a-Lipoic acid / D, L-Thioctic acidLuteolinLycopeneMelatoninMethimazoleNaringeninNaringinNadifloxacin

N0161N3378N5550N5669O1176O1177O1178O1179P3465P5845P6857P7060P8117P8118R1776R1806S1968S3345T7132V3276V3277

b-NaphthoflavoneS-NitrosoglutathioneNomilinNordihydroguaiaretic acidn-Octyl Caffeaten-Octyl-3,4-Dimethylcaffeatn-Octyl-3-methylcaffeaten-Octyl-4-methylcaffeatePiperinePolydatinProtocatechuic acidProtocatechuic Acid Ethyl mesterPuerarin, 99%Puerarin, 96%ResveratrolRebamipideSeratrodastSilymarinTriacetyl ResveratrolVitamin E, NaturalVitamin E / dl-a-Tocopherol


AntipsychoticsA2658A5234A7034C0247C0270C2947C3477C4757C4759F4584F4780F4783H0142H9714H9717I4659K1678L0349N1822P0144Q8019R1977R1978R3475S1971S9753T2936V0147V1854Z3463

AgomelatineAmisulprideAripiprazoleCalcineurin Autoinhibitory PeptideCarbamazepineChlorpromazine HClCitalopram HydrobromideClozapineClozapine N-oxideFluphenazineFluoxetine HClFluvoxamine MaleateHaloperidolL-5-HydroxytryptophanHydroxyzine DihydrochlorideIloperidoneKetanserinLamotrigineNefazodone HClPaliperidoneQuetiapine FumarateRetigabineRetigabine DihydrochlorideRisperidoneSertraline HydrochlorideSynephrineThioridazine HClValproic Acid Sodium SaltVenlafaxine HClZiprasidone


Apoptosis Detection/CaspasesA4930C9782D1627F0010F0011F0012F0014F0015F0016F0017F0018F0019F0020F0021F0022F0023F0024F3473M0115M0116M0117M0118M3378S7080S7081S7082S7083S7084T5677V3252Z1216

7-Amino-actinomycin DCytotoxicity Test KitDehydrocostus LactoneFAM FLICATM Poly Caspases Assay Kit FAM FLICATM Caspase 1 Assay KitFAM FLICATM Caspase 2 Assay KitFAM FLICATM Caspase 6 Assay KitFAM FLICATM Caspase 8 Assay KitFAM FLICATM Caspase 9 Assay KitFAM FLICATM Caspase 10 Assay KitFAM FLICATM Caspase 13 Assay KitFAM-Phe-CMK FLISPTM Assay KitFAM-Lys-CMK FLISPTM Assay KitFAM-Leu-CMK FLISPTM Assay KitFAM-Spacer-Phe-CMK FLISPTM Assay KitFAM-Spacer-Leu-CMK FLISPTM Assay KitFAM-Leu-DAP FLISPTM Assay KitFisetinMagic Red TM Caspases 3 & 7 Assay KitMagic Red TM Cathepsin B Assay KitMagic Red TM Cathepsin K Assay KitMagic Red TM Cathepsin L Assay KitMitoPTTM KitSR Poly Caspases Assay KitSR Caspases 3 & 7 Assay KitSR Caspases 9 Assay KitSR-101-Phe-CMK FLISPTM Assay KitSR-101-Leu-CMK FLISPTM Assay KitTotal Cell Death Assay KitVinorelbine DitartrateZ-D-E-V-D-AMC


Apoptosis InducersA0025A0817A0818A0819A0917A0934A1318A4440A4515A4577A4844A4845A4846A4847A4850A4940A5001A5037A5045A5373A5378A6132A6229A6234A7085B0025B0133B1545B1603B1853B1874B1876B1879B1979B3209B3210B4402B4517B6816B8275B8276C0150C0152C0154C0155C0156C0246C0344C0346C1867C1869C2818C2844C2845C2916C2946C2948C3210C3260C4402C4557

17-AAGD,L-1’-Acetoxychavicol acetate15-AcetoxyscirpenolAcetylsalicyclic acid/ Aspirin1’ S-1’-Acetoxychavicol AcetateAcivicinAdenineAllicinAlendronate Monosodium TrihydrateAlsterpaulloneAmylin (8-37), humanAmylin (8-37), ratAmylin (IAPP)(Feline))Amylin, humanAmylin, rat6-AminonicotinamideAminopterinAmiodarone HClAmlodipineAnisomycinAntimycin AApicidinAphidicolinApigeninArvanilBalfilomycin A1BaicalinBenzalkonium BromideBeauvericin1,4-BenzoquinoneBestatine Hydrochloride BetamethasoneBetamethasone ValerateBetulinic AcidBicalutamideR-BicalutamideBlasticidin S HClBleomycin A5 hydrochlorideBrefeldin An-Butyric acidButyric acid sodium saltCamptothecinCamptothecin, 9-aminoCamptothecin, 7-ethyl-10-hydroxy (SN-38)Camptothecin, 10-hydroxyCamptothecin, 9-nitro-20(S)CalcimycinCalphostin CCalyculin ACeramideCeruleninChelerythrine ChloramphenicolChloramphenicol LevoChenodeoxycholic acidChlorambucilChloroadenosineCiglitazoneCiprofibrateCladribineClofibrate

C4559C5645C5654C5771C5968C9609C9662C9709D0011D0182D1695D1749D3200D3218D3221D3232D3330D3374D3420D5709D5794E0813E6231E6232E6233E6234E6880E7657E7658E8657F0268F3473F4480F4501F4502F8149F8150G0144G1650G1652G1745G1869G3453G3558G4434H0142H1794H1892H5654H9613H9861I1400I5034I5315I5752I5753I6932I6933I7256I7356I7359

Clomiphene CitrateColchicine, 97%Concanavalin ACorticosteroneCordycepinCyclophosphamide Cyproterone AcetateCycloheximideDacarbazineDaunorubicin HydrochlorideDexamethasone Sodium PhosphateDemecolcineDiacetoxyscirpenolDiethylstilbestrolDifluoromethylornithine3,3’-DiindolylmethaneDihydrotanshinoneDisulfiram3,4 DifluorobenzocurcuminDocetaxelDoxorubicin HClEcdysterone(-)Epicatechin(-)Epicatechin gallate(-)EpigallocatechinEpigallocatechin gallateErucinEtoposideEtoposide PhosphateEvodiamineFarnesolFisetin5-FluorouracilFlavanoneFlavokawain AFumonisin B1Fumonisin B2GalactosamineGeniposideGenisteinGemcitabine HydrochlorideGeranylgeraniol20(S)-Ginsenoside Rh220(R)-Ginsenoside Rh2GliotoxinHaloperidolHexamethonium bromide hydrateHexamethylene bisacetamideHonokiolN-(4-Hydroxyphenyl)retinamideHypericinIdarubicin HClImiquimodIndomethacinIonomycin Free AcidIonomycin calciumIrinotecanIrinotecan HCl trihydrateIsobavachalconeIsopropyl Thiogalactoside1-Isothiocyanato-8-(methylsulfenyl)-octane


Apoptosis InducersI7447I7558K0117L0107L1682L1684L5648L5658L8377M0125M0172M1669M1877M3321M3377M5753N3225N3228N3378N3584O1176O1177O1178O1179P0092P0093P0270P1755P1770P2815P3210P6818P7012P7057P7058P7219P8168P8270R2917R5772R5773S0032S0033S1609S5749S6129S6130S6131S7600S7701S8147S8247T0091T0095T0109T0152T0250T1677T1679T1777T1849

1-Isothiocyanato-6-(methylsulfenyl)-hexane1-Isothiocyanato-9-(methylsulfenyl)-nonaneKaempferol, 95%LactacystinLevamisole HClLevonorgestrel LomustineLonidamineLuteolinMagnololMastoparan6-Mercaptopurine monohydrate MethylprednisoloneMifepristoneMitomycin CMonensin sodiumNigericin sodiumNifidepineS-NitrosoglutathioneNivalenoln-Octyl Caffeaten-Octyl-3,4-Dimethylcaffeaten-Octyl-3-methylcaffeaten-Octyl-4-methylcaffeatePaclitaxelPaclitaxel (Semi-synthetic)ParthenolidePentoxifyllinePerillyl AlcoholPhenylbutyratePicoplatinPrednisolonePrednisolone sodium phosphateProtodioscinProtocatechuic aldehydePseudolaric Acid BPuromycinPurvalanol ARheinRosiglitazone MaleateRosiglitazoneSaikosaponin B1Saikosaponin B2SecurinineSomatostatin-14D-SphingosineSphingosine-1-phosphateSphingosine, N,N-dimethylStaurosporineStanozololSulindac sulfideSulfasalazine7-(triethylsilyl)-10-deacetyl Baccatin IIIBaccatin III13-Acetyl-9-dihydrobaccatin-IIITandutinibTamoxifen citrateTetracyclineTetracycline HClTetrandrineTemozolomide

T3305T3310T5769T6933T7032T7033T7035T7044T7056T8004T8153U0618V0145V3252V3479W5726W5769Z1602Z1970

TiboloneTiclopidine HClToremifene BaseTrichostatin ATriamcinoloneTrifluoperazine HClTriptolideTriamcinolone Acetonide AcetateTroglitazoneTubeimoside ITunicamycinUbenimexValinomycinVinorelbine DitartrateVitamin K3WogoninWortmaninZearalenoneZerumbone


Apoptosis InhibitorsA4931A5044A5326B5753E0073F4583F4680G2868H1893H8162M1644M1676P0013P3313T3310

3-AminobenzamideAmlodipine besylateAniracetamBongkrekic acidEbselenFlupirtine MaleateFlutamideGhrelin, humanHexarelin(-)-Huperzine AMeloxicamMethotrexateP7C3PidotimodTiclopidine HCl


Biologically Active PeptidesA0099A0248A0249A0812A0825A0826A0832A0834A0960A0961A0962A0963A0964A0965A0966A0967A0968A0970A0971A1084A1097A1330A1331A1332A1333A1368A1369A1370A1371A2412A4369A4401A4438A4498A4844A4845A4846A4847A4848A4849A4850A4851A4852A4853A4854A5070A5225A5228A5272A5273A5275A5276A5277A5278A5279A5280A5281A5282A5283A5284A5285

A-779BAM-12PBAM-22PAc-D-EAc-GPK-pNAAc-GPK(Ac)-pNAAc-IEAR-pNAAc-IETD-pNAACTH (1-39), humanACTH (1-39), ratACTH (1-4)ACTH (1-10), humanACTH (1-13), humanACTH (1-14)ACTH (1-16), humanACTH (1-17), humanACTH (1-24), humanACTH (18-39), humanACTH (4-10), humanAc-VEID-pNAAc-YVAD-pNAAdipokinetic HormoneAdipokinetic Hormone, AKH, locustAdipokinetic Hormone II from LMAdipokinetic Hormone II from SGAdrenomedullin (1-52), humanAdrenomedullin (13-52), humanAdrenomedullin (22-52), humanAdrenorphinA-G-D-VA-K-R-R-R-L-S-S-L-R-AA-L-A-LAllatostatin IAlytesinAmylin (8-37), humanAmylin (8-37), ratAmylin (IAPP)(Feline)Amylin, humanAmyloid-b Protein (1-40)b-Amyloid (25-35)Amylin, ratb-Amyloid (1-40), ratb-Amyloid (1-40), Ultra Pure, TFAb-Amyloid (1-42), humanb-Amyloid Peptide (1-42), ratAngiotensin Acetatea-ANF (1-28), humanAngiogeninAngiotensin, Canine, RatAngiotensin Converting Enzyme InhibitorAngiotensin I [Des-Asp1-], humanAngiotensin I, humanAngiotensin II, humanAngiotensin III, humanAngiotensin II (1-4), humanAngiotensin II (3-8), humanAngiotensin II (4-8), humanAngiotensin II [Sar1 Ile8] Angiotensin II [Sar1]Angiotensin II, human [Val5][Ile7] Angiotensin III

A5287A5458A5460A5461A5476A5477A5479A6002A6017A6268A6827A7071A7072A7657A7669A7670A8071A8077B0000B0072B0108B3324B3346B5560B5561B5608B5609B5610B5611B5648B5649B6800B6802B6803B6804B6805B6806B6807B6808B6809B6810B6811B6812B6813B8010B8271C0140C0146C0148C0149C0151C0153C0172C0175C0243C0244C0245C0247C0248C0249C0250

Angiotensinogen (1-14), humanAnorexigenic PeptideANP (1-11), ratANP (1-30), frogAntagonist GAntide AcetateAntiestrogenApaminApelin-13, human, bovineAprotininArgpressin AcetateAtriopeptin II (rat, rabbit, mouse)Atriopeptin IIIAtosiban AcetateAtrial Natriuretic Peptide (1-28), ratAtriopeptin IAuriculin AAutocamtide 22B-(A)2B-(S)BactenecinBig Endothelin-1 (1-38), humanBrain injury-derived Neurotrophic Peptide (3)BNP (1-32), ratBNP (1-32), humanBoc-FAAGRK-AMCBoc-GRR-AMCBoc-PRR-AMCBoc-RRR-AMCBombesin[Tyr4] Bombesin Bradykinin triacetateBradykinin (1-3)Bradykinin (1-5)Bradykinin (1-6)Bradykinin (1-7)Bradykinin (2-9)Bradykinin [Des-Arg9]Bradykinin [Des-Pro2]Bradykinin [DPhe7]Bradykinin [Hyp3][Tyr8] Bradykinin Bradykinin Potentiator BBradykinin Potentiator CBuccalinBursinCalcitonin, eelCalcitonin, chickenCalcitonin, humanCalcitonin, salmona-Calcitonin gene Related Peptide, humanCalcitonin, ratCarbimazoleCarbetocin AcetateCalcitonin Gene Related Peptide (8-37), humana-Calcitonin Gene Related Peptide, chickenCalcitonin Gene Related Peptide, ratCalcineurin Autoinhibitory PeptideCalcineurin SubstrateCalcitonin Gene Related Peptide (8-37), ratCalcitonin Gene Related Peptide II, human


Biologically Active PeptidesC0251C0372C0374C0375C0379C0476C1600C1601C1609C1619C1621C1622C1623C1868C1879C2468C2971C4274C5196C5260C5646C5655C5656C5768C5770C5772C5773C5774C6018C6019C6916C6982C7098C7602C7618C7692C7693C7997C7998D0025D0044D0254D1643D1644D1767D1768D1769D1770D1775D1776D1777E2424E2542E4408E4416E4417E5210E5211E5212E5214E5215

Calcitonin Gene Related Peptide II, ratCasein Kinase 2 Assay Kitb-Casomorphin, humanCaspase 3, Substrate,ColorimetricCatch-Relaxing Peptide (CARP)CB-THCEA (605-613)CEA (605-613) analogueCecropin BCEF3CEF4CEF6CEF10CerebellinCetrorelix Acetateb-CGRP, humanChromostatin, bovineCKS-17C-Myc PeptideCNP-22, human, porcine, ratCollagen Binding Fragmenta-Conotoxin GIa-Conotoxin IMICorazoninCorticotropin Releasing Factor, bovineCorticotropin Releasing Factor, human, ratCortistatin-14Corticotropin Releasing Factor, ovineC-Peptide, dogsC-Peptide, humanCREBtideCrustacean Cardioactive Peptide, CCAPCrystallineCTAPC-telopeptideCTX IV (6-12)[Arg3,14] CTX IV (3-14)C-Type Natriuretic Peptide (1-22), humanC-Type Natriuretic Peptide, chickenDAGOD-Ala-D-AlaDansyl-Y-V-GDelta Sleep Inducing PeptideDeltorphin IDermenkephalinDermaseptin IDermorphinDermorphin AnalogDeslorelin AcetateDesmopressinDesmopressin AcetateEgg Laying Hormone of AplysiaMet-Enkephalin, amideElcatonin AcetateEledoisinEledoisin Related PeptideEndomorphin-1Endomorphin-2Endonuclease Antigenic Sitea-EndorphinAcetyl, a-Endorphin

E5216E5217E5218E5219E5220E5221E5222E5240E5241E5276E5277E6376E6993E6997E9416E9417E9418F3204F3205F3206F3207F3208F3209F4400F4420F4580F4856F4857F4858F4859F5869F5870F5871F5872G0000G0044G0096G0146G0147G0148G0175G0178G0179G0180G0181G0182G2368G2868G2869G2870G2871G2872G2873G2874G2968G2969G4479G4480G4481G4482G4483

a-Endorphin, camela-Endorphin, humana-Endorphin, ratEndothelin-1, humanEnfuvirtide (T-20)Endothelin-2, humanEndothelin-3, humanLeu-EnkephalinMet-EnkephalinEnterostatin, humanEnterostatin, porcine, ratEptifibatideErythromycin resistance peptide MRLFVErythropoietinExendin-3Exendin-4Exendin (9-39)Fibrinogen-binding PeptideFibrinogen g-chain dodecapeptideFibrinolysis Inhibiting FactorFibronectin CS-1 PeptideFibrinopeptide B, humanFibronectin-Binding ProteinFlag ProteinBoc-F-L-F-L-FFluM1 A2 (58-66)Fmoc-Lys(Boc)-Leu-Lys(Boc)FMRF amideFMRF-like peptide from SnailF-M-R-FN-Formyl-Met-Ala-SerN-Formyl-Met-Leu-PheN-Formyl Met-Leu-Phe-LysN-Formyl-Nle-Leu-Phe-Nle-Tyr-LysG250.A2GalantideG-A-YGalanin, humanGalanin, porcineGalanin, ratGastric Inhibitory Peptide (GIP), humanGastrin, chickenGastrin-1, ratGastrin I, humanGastrin Releasing Peptide, humanGastrin Releasing Peptide, porcineG-F-RGhrelin, humanGhrelin, ratGHRF (1-44), humanGHRF, bovineGHRF, mouseGHRF, ovineGHRF, ratGHRP-2GHRP-6Glucagon (19-29), humanGlucagon, humanGlucagon-Like Peptide I (7-36), amide, humanGlucagon-Like Peptide I (7-37); GLP-1 (7-37)Glucagon-Like Peptide II, human


Biologically Active PeptidesG4484G4485G5752G5772G6000G6368G6400G6803G6856G8103G8104H0100H0207H1643H1644H1645H1646H1648H1657H1661H1662H1663H1893H2876H2980H3272H3273H3274H3275H3276H3277H3278H8048I5215I5476K0144K0172K0276K1650K1674K2412K3352K4401K6864K9858L0248L0249L0250L0251L1628L1660L1661L1735L1881L1980L1981L1983L2876L3362L3577L8276

Glucagon-Like Peptide II, rat[Ala19] Glucagon-Like Peptide II, rat Gonadorelin AcetateGoserelin Acetategp38G-P-RG-QGranuliberin RGrowth Hormone Releasing Factor, HumanGuanylin, humanGuanylin, rat, mouseHA PeptideHBV core protein (128-140)HeloderminHelodorminHelospectin IHelospectin IIHemorphin-7Heparin-Binding PeptideHBV Core protein (128-140)HER2/neu (654-662) GP2HER2/neu (869-877)HexarelinH-Trp-Gly-OHHumanin (human)His TagHistatin 5HIV p17 Gag (77-85)HIV Integrase Protein Inhibitor(1)HIV Protease SubstrateHisterlin AcetateHIV RT (pol) A2.1 peptideHuman Follicular Conadotropin Releasing Peptide IndolicidinInterleukin-6 Receptor (partial)Kallikrein InhibitorKassininKatacalcinKemptideKetolide resistance Peptide MRFFVK-G-D-SKinetensinKL-1K-R-Q-H-P-GKyotorphinLaminin peptide YIGSRLaminin peptide YIGSR-NH2Laminin peptide SIKVAVLaminin peptide CDPGYIGSRAc-LEHD-PNALeptin (22-56), humanLeptin (116-130), mouseLevitideLeuprolide Acetate SaltLeucokinin ILeucokinin VIIILeucomyosuppresin (lms)LHRH-III, lampreyb-Lipotropin (61-64)LitorinLHRH

L8277L8278L9875L9880M0035M0040M0124M0126M0144M0172M0173M0224M0272M0273M0275M0276M1646M1647M1648M1649M1650M1744M1752M2460M3219M3220M5675M5776M7528M7529M7530M7531M7532M9356M9643M9644M9645M9646N0075N0160N1873N1977N1978N1979N1980N1981N1982N1983N1984N1985N1986N1987N1988N1989N1990N1991N1992N1993N1994N1995N5210

[Gln8] LH-RH, chickenLH-RH, salmonLys(Boc)-Leu-Lys(Boc)-ObzlLysipressin AcetateM35M40Magainin 1Magainin 2MalantideMastoparanMastoparan XMAGE-3 Antigen (271-279), humanMas7Mas8Mas17Mast Cell Degranulating PeptideMCH, human, mouse, ratMCH, salmonMelanostatin, frogMelanoma-associated antigen peptideMelanotan IIMelittin (Mellitin)Men 10376MGP-pNAMIF-1 TyrTyr-W-MIF-1Motilin, canineMotilin, porcinea-Melanocyte stimulating hormoneb-Melanocyte stimulating hormone, human[Nle4, D-Phe7] a-Melanocyte stimulating hormone g 1-Melanocyte stimulating hormoneg 3-Melanocyte stimulating hormoneMyomodulinMyelin Basic Protein (1-11), humanMyelin Basic Protein (87-99), guinea pig, humanMyelin Oligodendrocyte Glycoprotein (35-55), ratMyelin Basic Protein (68-82), guinea pigNatamycinNAPNesiritide Acetate (BNP-32)Neurokinin A (4-10)Neurokinin BNeuromedinNeuromedin B, porcineNeuromedin C, porcine GRP (18-27)Neuromedin U, ratNeruopeptide Y (3-36), humanNeuropeptide FF F-8-F-NH2Neuropeptide K, porcineNeuropeptide Y, human, ratNeuropeptide Y (13-36), humang-Neuropeptide, rabbitNeurotensin[Gln4] Neurotensin[D-Trp11]-NeurotensinNeurotensin (1-11)Neurotensin (9-13)Neurotensin, frogNeurotensin, guinea pigNociceptin


Biologically Active PeptidesN5211N6020N6076N7604O0978O1078O6132O7116O8500O8503O9497P0001P0005P0006P0007P0008P0009P0010P0011P0055P0075P0260P0268P0269P0350P0351P0352P0353P1760P1762P1763P1764P1765P1766P1767P1768P1955P2445P2832P2833P2845P2859P2992P2993P2994P4403P4560P6850P6859P6977P7022P7034P7628Q4370R0250R0251R1752R2112R2353R2369R2510

NocistatinNPFN(p-Tosyl)-GPR-pNANTB (Naltriben)OctaneuropeptideOctreotide AcetateOpioid receptor antagonistOrexin-B, humanOvalbumin (257-264) antigen peptideOVA (323-339)OxytocinP1PACAP (1-27), human, ovine, ratPACAP (1-38), human, ovine, ratPACAP (6-27), human, ovine, ratPACAP (6-38), human, ovine, ratPACAP 38, frogPACAP-Related Peptide, humanPACAP-Related Peptide, ratP55-TNFRP75-TNFRPapain InhibitorParasin IParathyroid Hormone (1-34), bovinePancreatic Polypeptide, avianPancreatic Polypeptide, ratPancreastatin, porcinePancreatic Polypeptide, humanPeptide TPeptide YY, porcinePeptide YY, humanPep-1Peptide Standard 1Peptide B, bovinePeptide F, bovinePeptide YY(3-36), PYY, humanPentagastrinPGLaPHI, porcinePHI, ratPleomycinPhosphate Acceptor PeptidePhyllolitorinPhyllomedusinPhysalaeminPlasminogen Activator Inhibitor 1PLP (139-151)Prolactin-Releasing Peptide (1-31), humanProctolinPyr-Gly-Arg-pNAPressinoic AcidPrion Peptide (106-126), humanpTH-Related Protein (1-34), human, ratQ-K-R-P-S-Q-R-S-K-Y-LRanatensinRanatensin RRenin Inhibitor PepideRFDSP-F-NH2RFRP-1, humanRGD-4C

R2511R2512R2513R2514R2516R2599R3224R6871R6873S0006S0049S0171S0200S0381S1060S1061S1343S1604S1605S1606S1607S1843S1969S1970S2044S3351S3585S3586S5745S5747S5749S5750S5751S5752S5753S6019S6134S7871S7872S7908S7909S7910S7911S8005S8006S8007S8008S8009S8010S8011S8012S8013S8014S9754S9775T0076T0077T1673T1675T2970T3093

R-G-D-CRGDRGDSRGDVR-G-E-SR-G-Y-S-L-GRiginRR-SRCR-S-RS6-1Salmon Calcitonin AcetateSarafotoxin 6cSAMs PeptideSauvagineSCPASCPBAc-S-D-K-PSecretin AcetateSecretin, humanSecretin, porcineSecretin, ratL-SelectinSermorelin AcetateSerum Thymic FactorS-F-L-L-RSincalide (CCK-8)SIVmac239-1SIVmac239-2[Tyr1] Somatostatin[Tyr11] SomatostatinSomatostatin-14Somatostatin-28Somatostatin-25Somatostatin-28 (1-12)Somatostatin-28 (1-14)SperactSpinorphin, bovineStresscopin, humanStresscopin-Related Peptide, humanSuc-APA-pNASuc-LEPF-pNASuc-RGPF-pNASuc-SDPF-pNASubstance PSubstance P (1-4)Substance P (1-7)Substance P (1-9)Substance P (7-11)[Nle11] Substance P[Pro9] Substance P[Sar9] Substance P[Tyr8] Substance PSubstance P, Free AcidSyntide 2SysteminTATTAT 2-4Terlipressin AcetateTeripatartide AcetateThrombin Receptor AgonistThymopentin


Biologically Active PeptidesT3094T3096T3097T3098T3099T3100T3101T7036T7037T8020T9974U5233U6118U6854U6855U6856U6857U6858U6859U6860U6956U6957U6958U6959V0153V0160V0252V0273V0274V0275V1872V3360W4096X1752X1753Z0146Z1216Z2268Z6269

Thymopentin Acetate (TP-5)Thymosin a-1Thymosin a-1 AcetateThymosin b-4 AcetateThymus FactorThyrotropin-Releasing Hormone (TRH)TRH, Free AcidTriptorelin, [DTrp6]-LH-RH, AmideTriptorelin AcetateTuftsin[Asp371] Tyrosinase(369-377), humanUniversal TT epitope P2 (830-844)UperoleinUrocortin, humanUrocortin, ratUrocortin II, humanUrodilatin CCC/ANP-95-126Urocortin II, mouseUrocortin III, humanUrocortin III, mouseUroguanylin, humanUrotensin IUrotensin II, frogUrotensin II, humanVanilloid Receptor Subtype 1RC-160 (Vapreotide)Vancomycin HClVasoactive Intestinal peptide[Lys8] Vasopressin[Arg8] VasotocinVesicular Stomatitis Virus peptideVIP, guinea pigW-K-Y-M-V-M-NH2XeninXenopsinZ-Ala-Ala-Leu-pNAZ-D-E-V-D-AMCZ-F-R-AMCZ-Pro-D-Leu


Carcinogens and Tumor PromotersA0501A1368A1369A1370A1371A2044A2046A2048A2050A2052A2054A4931A5039A5202A6932A6933A6934A7462B1652C0022C0029C2847C2965C4557C9662E6259G4535G4596H1894H9620I5072M9268O0829O4101O4102O4104O9398P0278P2856P2857P5878R8076S5746S8251T0081T2801U5232

AbamectinAdrenomedullin (1-52), humanAdrenomedullin (13-52), humanAdrenomedullin (22-52), humanAdrenorphinAflatoxin B1Aflatoxin B2Aflatoxin G1Aflatoxin G2Aflatoxin M1Aflatoxin M23-AminobenzamideAmitrazAnabasine HClAristolochic acid AAristolochic acid BAristolochic acid CAspartameBenzo[a]pyreneCafestol palmitateCafestol oleateChlormadinone AcetateChromium PicolinateClofibrateCyproterone AcetateEpoxiconazoleGlimepirideGlycidamideHexestrol7-Hydroxyaristolochic acid AImazalilMyristicinOchratoxin AOkadaic acidOkadaic acid, ammonium saltOkadaic acid, sodium saltOxymetazoline HClPatulinPhorbol-12, 13-dibutyratePhorbol-12-myristate-13-acetatePotassium canrenoateRutin HydrateSolanesolSulfuramidTaurineThapsigarginUniconazole


CardiovascularA0802A0819A0833A4523A5044A5045A5133A5230A7618A7658B3272B3275B3280C0253C0254C0365C1668C3446C4556C4558C4658C9779D0262D1621D3362D3447D5690E5200E5201E5202E6376E9816F1654F1745F1853F4482F5773F8270G1749H1658H9614I5414I6804I7259I7360I9804L0226L1884L3374L5751L5822L5873M0248M1685M1687M1779M1879M3368M3453M5746N0123

AcarboseAcetylsalicylic Acid / AspririnAcipimoxAlfuzosin HClAmlodipine besylateAmlodipineAmiloride HClAngiostatinAtenololAtorvastatinBis(3,5-dibromosalicyl) fumarateBis(3,5-dibromosalicyl) succinateBis(saclicyl) fumerateCandesatanCandesartan Celexetil EsterCarvedilolCerivastatin SodiumCilnidipineClofibric AcidClonidine HClClopidogrel SulfateCytisineDapiprazole HClDeferasiroxDipyridamoleDiltiazemDoxazosin MesylateEnalaprilatEnalapril MaleateEnalaprilEptifibatideEzetimibeFenoldopam mesylateFelodipineFenofibrateFluvastatin SodiumFosinopril SodiumFurosemideGemfibrozilHeparin sodiumHydrochlorothiazideIndapamideIrbesartanIsoproterenol HydrochlorideIsosorbide MononitrateIrbesartanLagochilineLevosimendanLisinoprilLomerizine HydrochlorideLofexidine HClLosartan potassiumManidipine HClMevastatinMevinolin / LovastatinMethyldopa sesquihydrateMetoprolol TartrateMirtazapineMinoxidilMolsidomineNaftopidil

N0262N0263N3208N3301N3422N3448P1869P3576P6800P6801Q8134R0154R0249R3374R3584R5974S0044S0045S0047S3313S3449S3476S6168S6235T1644T1670T1750T6803T7133U6801U6802U6854U6855U6856U6858U6859U6860V0146V1749W0269W0270

Naphazoline HClNaphazoline NitrateNicardipineNiacinNifekalant HydrochlorideNimodipinePerindoprilPitavastatin CalciumPravastatin LactonePravastatin SodiumQuinapril HClRanolazine DihydrochlorideRamiprilRisedronic acidRivaroxabanRosuvastatin CalciumSalbutamol Free BaseSalbutamol SulfateSalsolineSildenafil CitrateSimvastatinSitagliptin Phosphate MonohydrateSpiraprilSpironolactoneTelmisartanTerazosin HCl DihydrateTemocapril HClTrandolaprilTrimetazidineUrapidilUrapidil HClUrocortin, humanUrocortin, ratUrocortin II, humanUrocortin II, mouseUrocortin III, humanUrocortin III, mouseValsartanVerapamil HClWarfarinWarfarin Sodium


COX-2 InhibitorsC0267C0351C1644C3210E7556L5993L8248N0114N3322N3450R5722R5773R8179T5846V0245

CarnosolCarprofenCelecoxibCiglitazoneEtodolacLoxoprofenLumiracoxibNadifloxacinNiflumic acidMiesulideRofecoxibRosiglitazoneRutaecarpine (synthetic)Tolfenamic acidValdecoxib


FlavanoidsA6234B3358B6857C0278C2800C2968D0032D0033D3356D3357F3357F4501G4798G4799H1672H1673I0901I6068I7357K0117L8377M1780M9367N0068N0069N0161N5605Q8016S3353W5726

ApigeninBiochanin A4-BromoflavoneCatechin, 99%Chalcone 97%ChrysinDaidzeinDaidzinDiosmetinDiosminFisetinFlavononeGlyciteinGlycitinHesperetinHesperidinIcariinIpriflavoneIsorhamnetinKaempferol, 95%LureolinMethyl HesperidinMyricetinNaringeninNaringinbeta-NaphthoflavoneNobiletinQuercetin dihydrateSilybinWogonin


Natural ProductsA0919A0958A0977A1332A1333A4544A5130A5313A5314A6804A6932A6933A6934A6978A7332A7333A8070A9817B0025B0026B0109B0133B1753B1668B1769B1870B1874B1979B3345B3358B6801B6916B6917B6918B6919B7016B7017B7019B7116B7118B7119B8144C0020C0021C0027C0033C0150C0152C0154C0155C0156C0168C0255C0260C0265C0266C0267C0269C0275C0277C0278

Acetyl-L-carnitineAconitineActinomycinAdipokinetic Hormone II from LMAdipokinetic Hormone II from SGAllyl disulfideAmphotericin BAndrographolideAndrographolide, DehydroArbutinAristolochic acid AAristolochic Acid BAristolochic acid CArtemisinin (Qinghaosu)Asiatic acid, 95%AsiaticosideAurapteneAzelaic AcidBafilomycin A1Bafilomycin B1BakuchiolBaicalinBenfotiamineBerteroin, 97%BergeninBerberine HCl hydrateBestatin HClBetulinic Acid(-)-BilobalideBiochanin ABrassininBrevetoxin 1 (PbTx-1)Brevetoxin 2 (PbTx-2)Brevetoxin 3 (PbTx-3)Brevetoxin 3 Acetate (PbTx-3 Acetate)Brevetoxin 6 (PbTx-6)Brevetoxin 7 (PbTx-7)Brevetoxin 9 (PbTx-9)Brevetoxin 10 (PbTx-10)Brevetoxin 3-42-carboxylic acid (PbTx-COOH/BTX-5)b-Naphthoyl brevetoxinBulleyaconitine ACafestolCafestol acetateCafestol linoleateCafestol stearateCamptothecinCamptothecin, 9-aminoCamptothecin, 7-ethyl-10-hydroxy (SN-38)Camptotecin, 10-hydroxyCamptothecin, 9-nitro-20(S)CanthaxanthinCantharidinCapsanthinCarnosic acidCapsaicin, naturalCarnosolb-CaroteneCastanospermineCatechin, 90%Catechin, 99%

C0370C0376C0377C0378C1718C2800C2803C2816C2818C2943C2961C2968C2970C3479C5645C5654C5680C5782C6957C7097C8017C8069C9600C9602C9611C9612C9613C9614C9615C9710C9878C9879C9880C9881C9882D0032D0033D0363D0368D1627D1628D1644D1748D1757D1759D1760D1761D1768D1769D3201D3202D3227D3229D3230

D3231

D3304D3330D3331D3356

CarrageenanCatharanthine baseCatharanthine sulfateCatharanthine tartrateCepharanthineChalcone, 97%ChartreusinCheirolin, 97%ChelerythrineChlorogenic Acd (from Eucommia Bark)Chondroitin Sulfate, chickenChrysinChyrsophanolCitrinColchicineConcanavalin ACoumestrolCoumarinCroton OilCryptotanshinoneCuelureCurcuminCyanopeptolin 1007Cyanopeptolin 1041Cyclosporin ACyclosporin CCyclosporin DCyclosporin HCyclosporin BCyclopamineCytochalasin ACytochalasin BCytochalasin CCytochalasin DCytochalasin EDaidzeinDaidzinDaptomycinDeoxysarcophine, 2-epi-16-Dehydrocostus Lactone5,6-DehydrokawainDeltorphin IDemeclocycline HClL-DeoxyalliinDeoxynivalenolDeoxynivalenol, 3-Acetyl-Deoxynivalenol, 15-Acetyl-Dermaseptin IDermorphinDiallyl sulfide, 97%Diallyl trisulfideDihydromethysticin7,8-Dihydrokawain1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-hydroxy-3-phenyl-propan-1-one1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-hydroxy-3-(4-methoxy-phenyl)-propan-1-oneDibenzoylmethane, 98%Dihydrotanshinonea, b-DihydroresveratrolDiosmetin


Natural ProductsD3357D3429D3431D4802D5794D5897D5898D7992E0812E4444E5057E5369E6231E6232E6233E6234E6235E6825E6880E6896E7309E7657E8657F0268F1669F4501F4502F4503F4858F5668F5745F5766F8048F8149F8150G0144G0145G0243G0245G1650G1652G1853G3351G3352G3353G3354G3355G3356G3357G3358G3359G3453G3454G3455G3456G3457G3458G3459G3460G3461G3552

DiosminDihydrocytochalasin B3,4-Dihydroxyphenyl Ethanol17-DMAGDoxorubicin HydrochlorideDoxycycline HyclateDoxycycline MonohydrateDTX-4b-EcdysoneEllagic acidEmodinEnrofloxacin(-)Epicatechin(-)Epicatechin gallate(-)EpigallocatechinEpigallocatechin gallateEpirubicin HClErgosterolErucinErysolin, 97%EsculetinEtoposideEvodiamineFarnesolFerulic acidFlavanoneFlavokawain AFlavokawain BFMRF-like peptide from SnailForskolinFolic AcidForchlorfenuron (KT-30)FumagillinFumonisin B1Fumonisin B2GalactosamineGallic acid(-)-GallocatechinGallocatechin GallateGeniposideGenisteinGenipinGinkgolic acids MixtureGinkgolic acid (13:0)Ginkgolic acidGinkgolide AGinkgolide BGinkgolide ABGinkgolide CGinkgolidesGinkgolide J20(S)-Ginsenoside Rh2Ginsenoside Rb1Ginsenoside RcGinsenoside RdGinsenoside ReGinsenoside Rg1Ginsenoside Rg2Ginsenoside F1Ginsenoside F220(S)-Ginsenoside Rg3

G3553G3554G3556G3557G3558G4518G5874G6817G8225H0169H5654H5750H8162H9620H9662H9759H9861I0416I0418I0901I4961I4962I5213I7357I7359I7447I7456I7457I7458I7459I7557I7558I7658I7659K0030K0031K0032K0034K0036K0038K0040K0088K0117K0172K0282K1653L0060L0076L0109L0209L0211L0226L0284L1735L1980L1981L1983L2876L3250L3454L3550

Ginsenoside Rb2 Ginsenoside Rb3 20(R)-Ginsenoside Rg3Ginsenoside Rh120(R)-Ginnsenoside Rh2Glucaric acid, calcium saltGossypolGreen tea polyphenolsGuggulsteroneHarringtoninHonokiolHomoharringtoninHuperizine7-Hydroxyaristolochic acid AHypocrellin BHypaconitineHypericinIberin, 97%Iberverin, 97%IcariinImperatorinIsoimperatorinIndole-3-carbinol hydrateIsorhamnetin1-Isothiocyanato-8-(methylsulfenyl)-octane1-Isothiocyanato-6-(methylsulfenyl)-hexane1-Isothiocyanato-7-(methylsulfinyl)-heptane1-Isothiocyanato-6-(methylsulfinyl)-hexane1-Isothiocyanato-9-(methylsulfinyl)-nonane1-Isothiocyanato-8-(methylsulfinyl)-octane1-Isothiocyanato-6-(methylsulfonyl)-hexane1-Isothiocyanato-9-(methylsulfenyl)-nonane1-Isothiocyanato-9-(methylsulfonyl)-nonane1-Isothiocyanato-8-(methylsulfonyl)-octaneKahweolKahweol acetateKahweol palmitateKahweol eicosanateKahweol linoleateKahweol oleateKahweol stearateKawainKaempferol, 95%KassininKavalactones MixtureKendomycinLappaconitineLatrunculin ALactalbuminLactoferrin (Bovine)LactuloseLagochilineLavendustin ALevitideLeucokinin ILeucokinin VIIILeucomyosuppressin (lms)LHRH-III, LampreyD-LimoneneLincomycin HClLimonin


Natural ProductsL3551L8262L8276L8277L8278L8377L9609M0114M0125M0172M0278M1677M1679M1744M3208M3210M3212M3308M3312M3408M3410M3476M3598M5794M5853M9367M9368M9634M9710N0068N0069N1858N3213N5550N5669N5778O0829O0977O1176O1177O1178O1179O4101O4200O4202O4204O4417O6132O7377P0092P0218P0219P0245P0253P0254P0270P0278P0370P0392P1761P1770

Limonin glucosideLupinineLuteinizing Hormone Releasing Hormone[Gln8] LH-RH, chickenLH-RH, salmonLuteolinLycopeneMadecassic acidMagnololMastoparanMatrine11-MethoxyyangoninMethysticinMelittinMicroginin 527Microginin 690Microginin 704Microginin 527 methyl esterMicroginin 690 methyl esterMicrocystin LR, desmethylMicrocystin (N-methyl-L)RMithramycinMizoribine HydrobromideMoxifloxacin HClMoniliforminMyricetinMyristicinMyriocinMycophenolic acidNaringeninNariginNeosolaniolNidulalNomilinNordihydroguiaretic acidNotoginsenoside R1Ochratoxin AOctopamine HCln-Octyl Caffeaten-Octyl-3,4-Dimethylcaffeaten-Octyl-3-methylcaffeaten-Octyl-4-methylcaffeateOkadaic acidOkadaic acid C8 diol esterOkadaic acid methyl esterOkadaolOleanolic acidOpioid receptor antagonist Ac-RFMWMK-NH2OstholePaclitaxel, (Taxol)PaeoniflorinPaeonolPalmatine Chloride HydratePanaxadiolPanaxatriolParthenolidePatulinParomomycin SulphatePaxillinePepstatinPerillyl alcohol

P1852P1853P1854P1952P2303P2304P2400P2410P2445P2502P2508P2819P2845P2856P2858P2995P2997P3209P3462P3463P3465P4008P5712 P5845P6857P6957P6958P7219P7318P7358P7359P8117P8118P8167P8168P6869P9770P9869Q8016R1774R1775R1776R2917R5874R5878R8178R8206R8207S0046S0047S0132S0133S0134S0170S0368S0830S0831S0930S1058S1059S1609

Penicillin G procainePenicillin V PotassiumPenicillic acidPenitrem APhallacidinPhalloidinPhenethyl caffeatePhenethyl dimethyl caffeatePGLaPhenethyl glucosinolate potassium salt, 97%Phenethyl isothiocyanate6-Phenylhexa-3,5-dien-2-onePhleomycinPhorbol-12,13-dibutyrate4-a-Phorbol-12-myristate-13-acetatePhyscionPhytic AcidPiceatannolPiperacillinPiperacillin sodiumPiperinePKC412PodophyllotoxinPolydatinProtocatechuic acidProtopanaxadiolProtopanaxatriolPseudolaric Acid BPseudoginsenoside F11Psoralen (Ficusin)PsoralidinPuerarin, 99%Puerarin, 96%Puromycin aminonucleosidePuromycinPurpurinPyrrolostatinPyridoxine HClQuercetin dihydrateResiniferatoxinResiniferonol-9,13,14-orthophenyl acetateResveratrolRheinRosmarinic AcidRotenoneRutaecarpineRubescensin Ab-RubromycinSalsolidineSalsolineSaikosaponin ASaikosaponin CSaikosaponin DSarafloxacin HClSarcophineR(+) Schisandrin AS(-) Schisandrin BSchisantherin AScopolamine N-butylbromideScopolamine HydrobromideSecurinine


Natural ProductsS1612S3033S3343S3345S3353S5200S6000S6232S6233S6234S8045S8046S8049S9753T0002T0008T0091T0093T0094T0095T0096T0097T0098T0099T0100T0101T0102T0103T0104T0105T0106T0107T0108T0109T0110T0114T0115T0116T0117T0118T0153T0154T1676T1678T1733T1777T1855T2801T2816T2834T3133T5604T5605T6834T7035T7197T8004T9946U7354V0145V1870

SedanolideShikimic acidSilybin SilymarinSinomenine HClSNA 1SparfloxacinSpiramycinSpiramycin HexanedioateSpiramycin EmbonateS-Sulforaphane, 96%R-SulforaphaneS-SulforapheneSynephrineT2 ToxinTacrolimus7-(triethylsilyl)-10-deacetyl Baccatin III2’-Acetyltaxol2’,7-bis AcetyltaxolBaccatin IIICephalomannine10-Deacetyltaxol-B 10-Deacetyltaxol-C10-Deacetylbaccatin-III10-Deacetyl taxol7-epi-10-Deacetyltaxol7-epi-TaxolTaxol-side chain diolTaxol-side chain methyl esterTaxol CXylosyltaxolXylosyltaxol C10-Deacetyl-7-xylosyltaxol, 90%13-Acetyl-9-Dihydrobaccatin-IIITaxanes Standards MixtureTaxanine MTaxol side chain acid2”,3”-DihydrocephalomannineBenzyl Analog of Taxol7-epi-CephalomannineTanshinones ITanshinone IIAL-TetrahydropalmatineD,L-Tetrahydropalmatine sulfateTeicoplaninTetrandrineTentoxinThapsigarginL-TheanineThiolutinThioctic AcidTobramycin (free base)Tobramycin SulfateTriacsin CTriptolideTryprostatin ATubeimoside ITylosin phosphateUsnic AcidValinomycinVerruculogen

V3253V3355V5254W3576W5726Y0052

Vinblastine sulfateVindolineVincristine sulfateWithaferin AWogoninYangonin


Neuroactive AgentsA0958A4802A4803A4805A5059A5234A5235A5476A6002A6922A7656A7668A7672A9801B0110B0133B0150B3345B7058B8248B8261B8363C0151C0172C0221C0243C0244C0245C0249C0250C0251C0262C1868C2949C2957C3472C3576C4517C5770C5773C7602C9611C9612C9613C9614C9615C9660C9778C9779D0169D1628D1629D3230

D3231

D3348D8014E2424E4416E4417

AconitineAmantadine HClAmantadine SulfateAmastatin HClAmoxapineAmisulprideAmitriptyline HClAntagonist GApaminArformoterol TartrateAtomoxetine HClAtracurium besylateAtrropine SulfateAzaperoneBaclofenBaicalinBambuterol HCl(-)-BilobalideBrompheniramine MaleateBumetanideBupivacaineBupropion HCla-Calcitonin Gene Related Peptide, humanCarbimazoleCaffeineCalcitonin Gene Related Peptide (8-37),humana-Calcitonin Gene Related Peptide, chickenCalcitonin Gene Related Peptide, ratCalcitonin Gene Related Peptide (8-37), ratCalcitonin Gene Related Peptide II, humanCalcitonin Gene Related Peptide II, ratL-CarnitineCerebellinChlorpheniramine MaleateCholesterolCisatracurium BesylateCitreoviridin AClenbuterol HClCorticotropin Releasing Factor, bovineCortistatin-14CTAPCyclosporin ACyclosporin CCyclosporin DCyclosporin HCyclosporin BCypermethrinCytarabineCytisineDarifenacin5,6-DehydrokawainDehydroepiandrosterone / DHEA1-(2,4-Dihydroxy-6-methoxy-phenyl)- 3-hydroxy-3-phenyl-propan-1-one1-(2,4-Dihydroxy-6-methoxy-phenyl)- 3-hydroxy-3-(4-methoxy-phenyl)- propan-1-one11,12-DimethoxydihydrokawainDU-14Egg Laying Hormone of AplysiaEledoisinEledoisin Related Peptide

E4419E4902E6432F0150F4584F4681F4780G0044G3453G3454G3455G3456G3457G3458G3459G3460G3461G3552G3553G3556G3557G3558G4634H1794H9759K0088K0282K9858L0349L1782L5660L5751N3378N5778O0977O0978O5212O6132O7116O9210O9497O9596P0013P0144P0397P7318R0110R0348R0349R3477S1058S1059S1060S1061S7871S8005S8006S8007S8008S8009S8010

Eletriptan Free BaseEmamectin B1 BenzoateEpinephrine (-)FamotidineFluphenazineFlumazenilFluoxetine HClGalantide20(S)-Ginsenoside Rh2Ginsenoside Rb1Ginsenoside RcGinsenoside RdGinsenoside ReGinsenoside Rg1Ginsenoside Rg2Ginsenoside F1Ginsenoside F220(S)-Ginsenoside Rg3Ginsenoside Rb220(R)-Ginsenoside Rg3Ginsenoside Rh120(R)-Ginsenoside Rh2GlipizideHexamethonium bromide hydrateHypaconitineKawainKavalactones MixturesKyotorphinLamotrigineLevodopaLoperamide HClLomerizine HydrochlorideS-NitrosoglutathioneNotoginsenoside R1Octopamine HClOctaneuropeptideOndansetron HCl dihydrateOpioid receptor antagonist Ac-RFMWMK-NH2Orexin-B, humanOxcarbazepineOxytocinOxybutynin HydrochlorideP7C3PaliperidonePazopanibPseudoginsenoside F11Ractopamine HClRamelteonRamosetronRitodrineScopolamine N-butylbromideScopolamine HydrobromideSCPASCPBStresscopin, humanSubstance PSubstance P (1-4)Substance P (1-7)Substance P (1-9)Substance P (7-11)[Nle11] Substance P


Neuroactive AgentsS8011S8012S8013S8014S8151S9753T1674T1776T6802T7156T8145U6957U6958U6959V0153V0274V0275V1810V1854V1870Y0052Z5653

[Pro9] Substance P[Sar9] Substance P[Tyr8] Substance PSubstance P, Free AcidSumartriptan SuccinateSynephrineTerbutalineD-TetrahydropalmatineTramadol HClTropisetron HClTulobuterolUrotensin IUrotensin II, frogUrotensin II, humanVanilloid Receptor Subtype 1 (VR1)[Lys8] Vasopressin[Arg8] VasotocinVecuronium BromideVenlafaxine HClVerruculogenYangoninZonisamide


Neurodegenerative DiseasesA4802A4803A4844A4845A4846A4847A4848A4849A4850A4851A4852A4853A4854A5234C0367C3251C3477C4757C4759D5753E5202E5575E7376G0044G0048G0106G0146G0147G0148G0246H8162H9816I1418K0133K1776L1782M1678M1749N1721P6901R0272R3586R5661T1298V0147Z5653

Amantadine HClAmantadine SulfateAmylin (8-37), humanAmylin (8-37), ratAmylin (IAPP), felineAmylin, humanAmyloid-b Protein (1-40)b-Amyloid (25-35)Amylin, ratb-Amyloid (1-40), ratb-Amyloid (1-40), Ultra Pure, TFAb-Amyloid (1-42), humanb-Amyloid Peptide (1-42), ratAmisulprideS-(-)-Carbidopa monohydrateCinnarizineCitalopram HydrobromideClozapineClozapine N-oxideDonepezil HydrochlorideEnalaprilEntacaponeEstradiolGalantideGABA, Gamma-amino butyric acidGabapentinGalanin, humanGalanin, porcineGalanin, ratGalanthamine Hydrobromide(-)-Huperzine A2-Hydroxy EstradiolIdebenoneKainic acidKetotifen FumarateLevodopa2-Methoxy EstradiolMemantine HClNefiravetamPramipexole DihydrochlorideRasagilineRivastigmine Hydrogen TartrateRopinirole HClTDZD-8Valproic Acid Sodium SaltZonisamide


NSAIDsA0816A0819A1017A5161B1640C0351C1876C4659C6955D3209D3303D3322E0073E5057E6994E6995E6996E7556F1652F1655F4481F4483F4582G0145I0481I0482I5315K1677K1978L1780L1817L5870L5993L8248M0125M0278M1622M1644M1979N0061N0062N0205N3322N3450O4672P2810P3269P6802S0048S0244S8145S8146S8147S8247T0153T0154T1654T5846T5944V0245

AcemetacinAcetyl salicylic acidAceclofenacAmpiroxicamBenzydamine HClCarprofenCetirizine DihydrochlorideClobetasol PropionateCromolyn sodiumDiclofenac, Sodium SaltDiacereinDiflunisalEbselenEmodinErythromycinErythromycin EthylsuccinateErythromycin thiocyanateEtodolacFenbufenFenoprofenFlurbiprofenFlufenamic acidFluocinolone AcetonideGallic acidIbuprofenS(+) IbuprofenIndomethacinKetoprofenKetorolac TromethamineLevocetirizine DihydrochlorideLeflunomideLornoxicamLoxoprofenLumiracoxibMagnololMatrineMefenamic acidMeloxicamMethyl SalicylateD-NaproxenD,L-NaproxenNabumetoneNiflumic acid NimesulideOlsalazine SodiumPhenylbutazonePiroxicamPranoprofenSalicinSalsalateSulindacSulindac sulfoneSulindac sulfideSulfasalazineTanshinone ITanshinone IIATenoxicamTolfenamic acidTolmetin sodiumValdecoxib


Phase II Enzyme InducersA5217B6801C2816E4444E6896E7329I0416I0418I7456I7457I7458I7459I7557I7658I7659N5550O4578P1770P2510P2515S8044S8045S8046S8049

Trans-AnetholeBrassininCheirolin, 97%Ellagic acidErysolin, 97%EthoxyquinIberin, 97%Iberverin, 97%1-Isothiocyanato-7-(methylsulfinyl)-heptane1-Isothiocyanato-6-(methylsulfinyl)-hexane1-Isothiocyanato-9-(methylsulfinyl)-nonane1-Isothiocyanato-8-(methylsulfinyl)-octane1-Isothiocyanato-6-(methylsulfonyl)-hexane1-Isothiocyanato-9-(methylsulfonyl)-nonane 1-Isothiocyanato-8-(methylsulfonyl)-octaneNomilinOltiprazPerillyl Alcohol4-Phenylbutylisothiocyanate3-Phenylpropyl isothiocyanateR,S-SulforaphaneS-Sulforaphane, 96%R-SulforaphaneS-Sulforaphene


Signal TransductionA0101A0102A0960A0961A0962A0963A0964A0965A0966A0967A0968A0970A0971A1332A1333A4577A4806A5134A5170A5334A5373A5478A6017A6234A9435B0109B0110B3345B5874B6998B8274B8363C0121C0148C0149C0160C0248C0252C0255C0270C1613C2818C2916C2970C3251C3446C3477C4558C4657C4757C5662C8500C8501C8502D0010D0255D0375D1629D1644D1748D1749

A23187, 4 BromoA23187, Ca-MgACTH (1-39), humanACTH (1-39), ratACTH (1-4)ACTH (1-10), humanACTH (1-13), humanACTH (1-14)ACTH (1-16), humanACTH (1-17), humanACTH (1-24), humanACTH (18-39), humanACTH (4-10), humanAdipokinetic Hormone II from LMAdipokinetic Hormone II from SGAlsterpaulloneAmbroxolAminophylline AnhydrousAmrinoneAnisodamineAnisomycinAntipainApelin-13, human, bovineApigeninAxitinibBakuchiolBaclofen(-)-BilobalideBosutinibBryostatin 1Buspirone HClBupropion HClCaffeic acidCalcitonin, humanCalcitonin, salmonCanrenoneCalcineurin SubstrateCanertinib DihydrochlorideCantharidinCarbamazepineCediranibChelerythrine ChlorideChenodeoxycholic acidChrysophanolCinnarizineCilnidipineCitalopramClonidine HClClotrimazoleClozapineCopper bis-3,5-diisopropylsaliccylateCV-65CV-66CV-703-H-1,2-dithiole-3-thioneDantrolene sodiumDasatinib MonohydrateDehydroepiandosterone / DHEADeltorphin IDemeclocycline HClDemecolcine

D1769D1774D1776D1777D1792D1859D3212D3214D3219D3228D3301D3302D3303D3320D3328D3351D3355D3356D3362D3372D3374D3429D3447D3462D4873D5607D5692D5792D5868E2542E5057E5210E5211E5240E5241E5575E6432E6846E7376F0275F3454F4584F4780F5668F5868G0048G0104G0106G0246G1653G4479G4480G4481G4482G4483G4484G4485G4535G4634G4796H0001

DermorphinDesloratadineDesmopressinDesmopressin AcetateDextromethorphan2-Deoxy-D-glucose2’,3’-Dideoxycytidine2’,3’-DideoxyinosineDiflubenzuronDihydromyristicinDiaveridineDiaveridine HClDiacereinDifenoconazoleDihydrokainic acid4-DimethylaminopyridineDiosgeninDiosmetinDipryidamoleDisodium Cycloheptylaminomethylene diphosphateDisulfiramDihydrocytochalasin BDiltiazemDiphenhydramine HClDMSA (Meso-2,3-dimercaptosuccinic acid)Dobutamine HClDoxifluridineDoxofyllineDoramapimodMet-Enkephalin, amideEmodinEndomorphin-1Endomorphin-2Leu-EnkephalinMet-EnkephalinEntacapone(-)-EpinephrineErlotinib MonohydrochlorideEstradiolFasudil HClFingolimod HClFluphenazineFluoxetine hydrochlorideForskolinFormoterol FumerateGABAGabexate mesylateGabapentinGalanthamine HydrobromideGenistinGlucagon (18-29), humanGlucagon, humanGlucagon-Like Peptide I (7-36), amide, humanGlucagon-Like Peptide I (7-37); GLP-1 (7-37)Glucagon-Like Peptide II, humanGlucagon-Like Peptide II, rat[Ala19] Glucagon-Like Peptide II, ratGlimepirideGlipizideGlycerol MonolaurateH7


Signal TransductionH0002H0003H0142H1669H8162H9759I4802I7256K0021K0022K0023K1650K1655K1678K7600K7602L0360L1884L3374M0248M0374M1560M1749M1976M3344M3453M5752M5756M8007N0262N1822N3346N5766O4556O9398P0001P0005P0006P0007P0008P0009P0010P0011P0049P0145P0146P0218P0253P0254P0255P0256P0260P0397P1200P1202P1753P1754P1755P1764P1766P1869

H-8, dihydrochloride saltH89HaloperidolHerbimycin AHuperizineHypaconitineImatinib MesylateIsobavachalconeK252aK252bK252CKemptideKenpaulloneKetanserinKT5720KT5823Lapatinib DitosylateLevosimendamLisinoprilManidipine HClMasitinibMethyl caffeateMemantine hydrochlorideMethimazoleMilrinoneMinoxidilMonastrolMontelukast SodiumMubritinib, Free BaseNaphazoline HydrochlorideNefazodoneNilotinibNorepinephrine BitartrateOlomoucineOxymetazoline HydrochlorideP1PACAP (1-27), human, ovine, ratPACAP (1-38), human, ovine, ratPACAP (6-27), human, ovine, ratPACAP (6-38), human, ovine, ratPACAP 38, frogPACAP-Related Peptide (PRP), humanPACAP-Related Peptide (PRP), ratPamidronate DisodiumPalmitoyl-DL-carnitine Palmitoyl-L-carnitine chloridePaeoniflorinPanaxadiolPanaxatriolPantoprazolePantoprazole sodiumPapain InhibitorPazopanibPD184352PD325901PenicillaminePenciclovirPentoxifyllinePep-1Peptide B, bovinePerindopril

P1955P2857P2859P2997P3209P3597P4008P4403P5878P6232P6850P6852P6854P6954P7020P7021P7022P7023P7033P8168P8270P9869R0109R0161R0212R1777R1779R1876R1878R1879R3205R3347R3577R5661R6871S0032S0033S0047S0168S0200S1061S3346S3584S5868S5869S5976S6129S6130S6131S7600S8098S8253T0152T0251T1298T2936T3350T5996T6802T6935T9968

PentagastrinPhorbol 12-Myristate 10- AcetatePhosphate Acceptor PeptidePhytic AcidPiceatannolPizotifen malatePKC412Plasminogen Activator Inhibitor 1 (PAI-1)Potassium canrenoatePP1Prolactin-Releasing Peptide (1-31), humanPropafenone HClProgesteronePioglitazone HClPrednisonePrednisone AcetatePressinoic AcidPregnenolonePrimaquine phosphatePuromycinPurvalanol APyridoxine HClRacecadotrilRapamycinRadicicol9-cis-Retinoic acid13-cis-Retinoic acidall-trans-Retinol / Vitamin ARetinyl acetateRetinyl palmitateRibavirinRiluzoleRitonavirRopiniroleRR-SRCSaikosaponin B1Saikosaponin B2SalsolineSaracatinibSAMs PeptideSCPBSilodosinSivelestat Sodium TetrahydrateSorafenibSorafenib TosylateSotalolD-SphingosineSphingosine 1-phosphateSphinosine, N,N-dimethylStaurosporineSU-1498Sunitinib MalateTandutinibTamsulosin HClTDZD-8Thioridazine HClTimolol MaleateTozasertibTramadol HydrochlorideTrimebutine baseTyrophostin A25


T9969T9970V0352V0376V1868W2933W5769

Tyrophostin AG490Tyrophostin AG1295VandetanibVatalanib DihydrochlorideVeratramineWHI-P131Wortmannin


Signal Transduction

Snake VenomsCrotalidaeAgkistrodon contortrix contortrixAgkistrodon contortrix laticinctusAgkistrodon contortrix mokasenAgkistrodon contortrix pictigasterAgkistrodon piscivorous leucostomaAgkistrodon piscivorous piscivorousBothrops atroxBothrops leucurusBothrops moojeniCalloselasma rhodostomaCrotalus adamanteusCrotalus atroxCrotalus basiliscusCrotalus cerastesCrotalus durissus collineatusCrotalus durissus cumanensisCrotalus durissus durissus (fmr. C.d.dryinas)Crotalus durissus terrificus(Paraguay)Crotalus horridusCrotalus horridus (Type A neurotoxin)Crotalus molossus (Texas origin)Crotalus scutulatus scutulatusCrotalus simus culminatus (fmr. C. durissus culminatus)Crotalus simus simus (fmr. C. d. durissus)Crotalus viridis viridisProtobothrops flavoviridisSisturus catenatus tergeminus

HelodermatidaeHeloderma horridumHeloderma suspectum

ElapidaeAspidelaps scutatus scutatus Dendroaspis angusticeps Dendroaspis jamesoni kaimosae Dendroaspis polylepis Micrurus fulvius fulvius Naja annulifera Naja kaouthia (Suphan province) Naja kaouthia Naja melanoleuca Naja naja (India) Naja naja (Pakistan) Naja nigricollis nigricollis Naja nivea Naja oxiana Naja pallida Naja siamensis Ophiophagus HannahOxyuranus scutellatus scutellatusOxyuranus scutellatus canniPseudechis colletti

ViperidaeAtheris chlorechisBitis arietans Bitis gabonica gabonica Bitis gabonica rhonoceros Daboia (Vipera) russelli russelli Daboia (Vipera) palestinae Echis carinatus sochurekiEchis pyramidium


* All venoms are collected in a sterile manner and frozen at - 70 °C before lyophilization.

* Other venoms are available upon request. Please contact us for more information on other species.

Alphabetical IndexA................................................................................. 37A-779 ......................................................................... 37A23187, 4-Bromo .................................................... 37A23187, Ca-Mg ........................................................ 37A23187, Free acid .................................................... 3717-AAG ..................................................................... 37Abamectin ................................................................ 37Acarbose ................................................................... 37Ac-D-E ...................................................................... 37Aceclofenac .............................................................. 37Acemetacin ............................................................... 37D,L-1’-Acetoxychavicol Acetate ........................ 5, 381’S-1’-Acetoxychavicol Acetate .......................... 5, 3815-Acetoxyscirpenol ............................................... 38N-Acetyl-D-Leucine ............................................... 38Acetyl-L-carnitine ................................................... 38N-Acetyl-L-Cysteine ............................................... 38N-Acetyl-S-(N’-benzylthiocarbamoyl)- L-cysteine ........................................................ 38N-Acetyl-S-(N’-methylthiocarbamoyl)- L-cysteine ........................................................ 38N-Acetyl-S-(N’-phenethylthiocarbomoyl)- L-cysteine ........................................................ 38N-Acetyl-S-(N’-phenylhexylthiocarbamoyl)- L-cysteine ........................................................ 38N-Acetyl-S-(N’-phenylthiocarbamoyl)- L-cysteine ........................................................ 38Acetylsalicylic Acid / Aspirin................................. 38Ac-GPK (Ac)-pNA .................................................. 39Ac-GPK-pNA ........................................................... 39Ac-IEAR-pNA .......................................................... 39Ac-IETD-pNA ......................................................... 39Acipimox .................................................................. 39Acivicin ................................................................. 6, 39Aconitine ............................................................19, 39Acrinol ...................................................................... 39ACTH (1-39), human ............................................. 39ACTH (1-39), rat ..................................................... 39ACTH (1-4) .............................................................. 39ACTH (1-10), human ............................................. 39ACTH (1-13), human ............................................. 39ACTH (1-14) ............................................................ 40ACTH (1-16), human ............................................. 40ACTH (1-17), human ............................................. 40ACTH (1-24), human ............................................. 40ACTH (18-39), human ........................................... 40ACTH (4-10), human ............................................. 40Actinomycin D......................................................... 40Actinomycin D, 7-Amino ....................................... 40Actinonin .................................................................. 40Ac-VEID-pNA ......................................................... 40Acycloguanosine ...................................................... 40Acyclovir ................................................................... 40Ac-YVAD-pNA ........................................................ 40Adapalene ................................................................. 40

Adenine ..................................................................... 41Adenosine Triphosphate disodium ....................... 41Adipokinetic Hormone ........................................... 41Adipokinetic Hormone II from Locusta migratoria ........................................ 41Adipokinetic Hormone II from Schistocera gregaria ..................................................................... 41Adipokinetic Hormone, AKH, locust ................... 41Adrenomedullin (1-52), human ............................ 41Adrenomedullin (13-52), human .......................... 41Adrenomedullin (22-52), human .......................... 41Adrenorphin ............................................................ 41Adriamycin ............................................................... 41Aeroplysinin ............................................................. 42Aflatoxin B1........................................................22, 42Aflatoxin B2........................................................22, 42Aflatoxin G1 .......................................................22, 42Aflatoxin G2 .......................................................22, 42Aflatoxin M1 ......................................................22, 42Aflatoxin M2 ......................................................22, 42A-G-D-V ................................................................... 42Agomelatine ............................................................. 42A-K-R-R-R-L-S-S-L-R-A ........................................ 42A-L-A-L..................................................................... 43Alamethicin .............................................................. 43L-Alaninol ..........................................................19, 43Alarelin Acetate ....................................................... 43Albendazole .............................................................. 43Albendazole sulfoxide ............................................. 43Alendronate ........................................................27, 43Alfacalcidol ............................................................... 43Alfuzosin Hydrochloride ........................................ 43Allatostatin I ............................................................. 43Allicin ........................................................................ 44L(+) Alliin ................................................................ 44L(±) Alliin ................................................................ 44Allopurinol ............................................................... 44Alloxan Monohydrate ............................................. 44S-Allyl-L-cysteine .................................................... 44Allyl Disulfide ...................................................11, 44Alsterpaullone .......................................................... 44Alternariol ................................................................ 44Alternariol-9-methyl ether ..................................... 45Altretamine .............................................................. 45Alyssin sulfone, 97% ............................................... 45Alyssin, 97% ............................................................. 45Alytesin ..................................................................... 45Amantadine Hydrochloride ................................... 45Amantadine Sulfate ................................................. 45Amastatin Hydrochloride ..................................... 45L-(+)-Amethopterin Dihydrate ............................. 45Ambroxol Hydrochloride ...................................... 45Amifostine ................................................................ 46Amikacin Disulfate ................................................. 46Amiloride HCl ......................................................... 467-Amino-actinomycin D ........................................ 463-Aminobenzamide ................................................ 466-Aminocaproic acid .............................................. 46


DL-Aminoglutethimide .......................................... 466-Aminonicotinamide ............................................ 46Aminopterin............................................................. 474-Aminophenylphosphate monosodium salt, 98% ................................. 47Aminophylline Anhydrous .................................... 47Aminophylline Dihydrate ...................................... 474-Aminosalicylic acid ............................................. 475-Aminosalicylic acid ............................................. 474-Aminosalicylic acid sodium dihydrate ............. 47Amiodarone Hydrochloride .................................. 47Amisulpride.............................................................. 47Amitraz ..................................................................... 48Amitriptyline Hydrochloride ................................. 48Amlexanox ............................................................... 48Amlodipine .............................................................. 48Amlodipine besylate................................................ 48Amorolfin Hydrochloride ...................................... 48Amoxapine ............................................................... 48Amoxicillin .............................................................. 48Amphotericin B ...................................................... 48Ampicillin Trihydrate ............................................. 49Ampiroxicam ........................................................... 49Amprolium Hydrochloride .................................... 49Amrinone ................................................................. 49Amsacrine ................................................................ 49Amygdalin ............................................................... 49Amylin (8-37), human ............................................ 49Amylin (8-37), rat .................................................... 49Amylin (IAPP)(Feline) ........................................... 49Amylin, human ....................................................... 49Amylin, rat................................................................ 50b-Amyloid (1-40), rat.............................................. 50b-Amyloid (1-40), Ultra Pure, TFA ...................... 50b-Amyloid (1-42), human ...................................... 50b-Amyloid (25-35) ................................................. 50b-Amyloid Peptide (1-42), rat ............................... 50Amyloid-b Protein (1-40) ....................................... 50Anabasine hydrochloride ....................................... 50Anagrelide ................................................................ 50Anastrozole .............................................................. 50Andrographolide ..................................................... 50Andrographolide, dehydro- ................................... 51Andrographolide, deoxy- ....................................... 51Anethole-trithione .................................................. 51a-ANF(1-28), human ............................................. 51Angiogenin ............................................................... 51Angiostatin ............................................................... 51Angiotensin Acetate ................................................ 51Angiotensin, Canine, rat ......................................... 51Angiotensin Converting Enzyme Inhibitor ......... 51Angiotensin I [Des-Asp1-], human ...................... 51Angiotensin I, human ............................................ 52Angiotensin II (1-4), human .................................. 52Angiotensin II (3-8), human .................................. 52Angiotensin II (4-8), human .................................. 52Angiotensin II [Sar1 Ile8] ....................................... 52Angiotensin II [Sar1] .............................................. 52

Angiotensin II, human ........................................... 52Angiotensin II, human [Val5] ................................ 52Angiotensin III, human ......................................... 52[Ile7] Angiotensin III .............................................. 52Angiotensinogen (1-14), human ........................... 52Aniracetam .........................................................18, 52Anisodamine .....................................................21, 53Anisomycin .............................................................. 53Anorexigenic Peptide .............................................. 53ANP (1-11), rat ........................................................ 53ANP (1-30), frog ...................................................... 53Antagonist G ............................................................ 53Antide Acetate ......................................................... 53Antiestrogen ............................................................. 53Antimycin A ............................................................. 53Antipain .................................................................... 53Apamin ..................................................................... 53Apelin-13, human, bovine ...................................... 54Aphidicolin ............................................................... 54Apicidin .................................................................... 54Apigenin ................................................................... 54Apramycin ................................................................ 54Aprepitant ................................................................. 54Aprotinin .................................................................. 54Arbutin...................................................................... 54Arformoterol tartrate .............................................. 54Argatroban .............................................................. 54L-Arginine ................................................................ 55L-Arginine Monohydrochloride............................ 55Na,Na-Dimethyl-L-Arginine, Ammonium Salt ............................................ 55Ng,N’g-Dimethyl-L-Arginine, Ammonium Salt ............................................ 55Argpressin Acetate .................................................. 55Aripiprazole .............................................................. 55Aristolochic acid A .................................................. 55Aristolochic acid B .................................................. 55Aristolochic acid C .................................................. 55Artemether ............................................................... 55Artemisinin ............................................................. 56Dihydro-Artemisinin ............................................. 56Artesunate ............................................................... 56Arvanil ..................................................................... 56Ascomycin ................................................................ 56L(+)-Ascorbic acid ................................................. 56Ascorbyl Palmitate .................................................. 56Asiatic Acid .............................................................. 56Asiaticoside .............................................................. 57Asparaginase ............................................................ 57Aspartame ................................................................ 57Aspirin ...................................................................... 57Atenolol..................................................................... 57Atomoxetine Hydrochloride .................................. 57Atorvastatin Calcium Trihydrate.....................26, 57Atosiban Acetate ...................................................... 57Atracurium besylate ................................................ 57Atrial Natriuretic Peptide (1-28), rat .................... 58Atriopeptin I ............................................................ 58


Atriopeptin II (rat, rabbit, mouse) ........................ 58Atropine Sulfate ....................................................... 58Auraptene ................................................................. 58Auriculin A ............................................................... 58Axitinib ...............................................................29, 58Azacitidine................................................................ 585-Aza-2’-deoxycytidine (Decitabine) ................... 59Azaperone ................................................................. 59Azathioprine ............................................................ 59Azelaic acid............................................................... 59Azelastine hydrochloride ........................................ 593’-Azido-3’-deoxythymidine.................................. 59Azithromycin ........................................................... 59Aztreonam ............................................................... 59AZT .......................................................................... 59

B ................................................................................. 592B-(A) ....................................................................... 592B-(S) ........................................................................ 59Baclofen ..............................................................21, 60Bactenecin, bovine .................................................. 60Bafilomycin A1 ....................................................... 60Bafilomycin B1 ........................................................ 60Baicalin ...............................................................15, 60Bakuchiol .................................................................. 60BAM-12P .................................................................. 60BAM-22P .................................................................. 60Bambuterol Hydrochloride .................................... 60BCNU ....................................................................... 60Beauvericin ............................................................... 61Benfotiamine ............................................................ 61Benzalkonium Bromide .......................................... 61Benzo[a]pyrene ..................................................11, 61Benzimidazole .......................................................... 611,4-Benzoquinone ................................................... 61S-Benzoylthiamine O-monophosphate ................ 61Benzydamine Hydrochloride ................................. 61O6-Benzylguanine ................................................... 61Benzyl isothiocyanate ......................................... 8, 61Benzyl selenocyanate ........................................12, 62S-(N-Benzylthiocarbamoyl)-L-cysteine .......... 8, 62Benzyl thiocyanate, 97% ......................................... 62Berbamine Hydrochloride, 95% ............................ 62Berberine hydrochloride hydrate .......................... 62Bergenin .................................................................... 62Berteroin, 97% ......................................................... 62Bestatin Hydrochloride .......................................... 62Betamethasone ......................................................... 62Betamethasone valerate .......................................... 62Betamethasone 21-phosphate sodium salt ........... 62Betulinic acid ........................................................... 63Bezafibrate ................................................................ 63Biapenem .................................................................. 63Bicalutamide ....................................................... 3, 63R-Bicalutamide .................................................... 3, 63Bifonazole ................................................................. 63Big Endothelin-1 (1-38), human ........................... 63Bilobalide .................................................................. 63

Biochanin A .......................................................14, 63Biopterin ................................................................... 64Biotin ......................................................................... 64Bisacodyl ................................................................... 64Bisazir ........................................................................ 64Bis(3,5-dibromosalicyl) fumarate.......................... 64Bis(3,5-dibromosalicyl) succinate ......................... 64Bis(salicyl) fumarate ............................................... 64Bitertanol .................................................................. 64Blasticidin S Hydrochloride .................................. 64Bleomycin A5 Hydrochloride ............................ 3, 64Bleomycin sulfate ................................................ 3, 65BNP (1-32), human ................................................. 65BNP (1-32), rat ......................................................... 65Boc-F-L-F-L-F.......................................................... 65Boc-FAAGRK-AMC ............................................... 65Boc-GRR-AMC ....................................................... 65Boc-PRR-AMC ........................................................ 65Boc-RRR-AMC ........................................................ 65Bombesin .................................................................. 65[Tyr4] Bombesin ...................................................... 65Bongkrekic acid .................................................18, 65Bortezomib ............................................................... 65Bosutinib .................................................................. 66Bothrops alternatus ................................................. 66Bothrops neuwiedi diporus .................................... 66Bradykinin ................................................................ 66Bradykinin (1-3) ...................................................... 66Bradykinin (1-5) ...................................................... 66Bradykinin (1-6) ...................................................... 66Bradykinin (1-7) ...................................................... 66Bradykinin (2-9) ...................................................... 66Bradykinin [Des-Arg9] ........................................... 66Bradykinin [Des-Pro2] ........................................... 66Bradykinin [DPhe7] ................................................ 66Bradykinin [Hyp3] .................................................. 66[Tyr8] Bradykinin .................................................... 66Bradykinin Potentiator B ........................................ 66Bradykinin Potentiator C ....................................... 67Brain injury-derived Neurotrophic Peptide (3) .. 67Brassinin ............................................................11, 67Brefeldin A .............................................................. 67Brevetoxin 1 (PbTx-1) ......................................31, 67Brevetoxin 2 (PbTx-2) ......................................31, 67Brevetoxin 3 (PbTx-3) ......................................31, 67Brevetoxin 3 Acetate (PbTx-3 Acetate) ..........31, 67Brevetoxin 6 (PbTx-6) ......................................31, 67Brevetoxin 7 (PbTx-7) ......................................31, 67Brevetoxin 9 (PbTx-9) ......................................31, 67Brevetoxin 10 (PbTx-10) ..................................31, 68Brevetoxin 3-42-carboxylic acid (PbTx-COOH / BTX-5) .........................31, 68b-Naphthoyl brevetoxin ......................................... 68Brivudine .................................................................. 68Bromhexine Hydrochloride ................................... 685-Bromo-2’-deoxyuridine ...................................... 684’-Bromoflavone ...................................................... 68Brompheniramine Maleate .................................... 68


Bryostatin 1 .............................................................. 68Buccalin .................................................................... 68Budesonide ............................................................... 68Bulleyaconitine A ..............................................19, 69Bumetanide .............................................................. 69Bupivacaine Free Base ............................................. 69Bupivacaine Hydrochloride .................................. 69Bupropion Hydrochloride ...................................... 69Bursin ........................................................................ 69Buspirone Hydrochloride .................................21, 69Busulfan ................................................................... 69Butoconazole nitrate ............................................... 69Butylated Hydroxyanisole ...................................... 69Butylated hydroxytoluene (BHT) ......................... 702-tert-Butyl-4-hydroxyanisole, 99% ..................... 703-tert-Butyl-4-hydroxyanisole, 99% ..................... 703-tert-Butyl-5-methoxy-1, 2-quinone .................. 704-tert-Butyl-5-methoxy-1, 2-quinone .................. 703-tert-Butyl-5-methoxy-catechol .......................... 704-tert-Butyl-5-methoxy-catechol .......................... 702-n-Butylthiophene, 97% ....................................... 70n-Butyric acid .......................................................... 70Butyric acid sodium salt ......................................... 70

C ................................................................................. 71Caerulomycin A ....................................................... 71Calcifediol ................................................................. 71Cafestol .............................................................12, 71Cafestol acetate ........................................................ 71Cafestol eicosanate .................................................. 71Cafestol linoleate ..................................................... 71Cafestol oleate .......................................................... 71Cafestol palmitate .................................................... 71Cafestol stearate ....................................................... 71Caffeic acid ........................................................10, 71Caffeine .................................................................... 71Calcimycin ................................................................ 71Calcineurin Autoinhibitory Peptide ..................... 72Calcineurin Substrate .............................................. 72Calcitonin, chicken.................................................. 72Calcitonin, eel .......................................................... 72Calcitonin, human ................................................... 72Calcitonin, rat .......................................................... 72Calcitonin, salmon .................................................. 72a-Calcitonin gene Related Peptide (GRP), chicken ............................................... 72a-Calcitonin GRP, human ...................................... 72Calcitonin GRP, rat .................................................. 72Calcitonin GRP (8-37), human ............................. 72Calcitonin GRP (8-37), rat ..................................... 73Calcitonin GRP II, human ..................................... 73Calcitonin GRP II, rat ............................................. 73Calcitriol ................................................................... 73Calcium folinate, pentahydrate.............................. 73Calphostin C ............................................................ 73Calyculin A ............................................................... 73Camptothecin .......................................................... 73Camptothecin, 9-Amino ........................................ 73

Camptothecin, 7-ethyl-10-hydroxy ...................... 74Camptothecin, 10-hydroxy .................................... 74Camptothecin, 9-nitro-20(S) ................................. 74Candesartan ............................................................. 74Candesartan Celexetil Ester ................................... 74Canrenoic acid potassium salt ............................... 74Canertinib Dihydrochloride .................................. 74Canrenone ................................................................ 74Cantharidin .............................................................. 74Canthaxanthin ......................................................... 74Capecitabine ............................................................. 75Capsanthin ............................................................... 75Capsaicin, natural ................................................ 5, 75Captopril ................................................................... 75Carbadox .................................................................. 75Carbamazepine ........................................................ 75Carbenoxolone. ...................................................... 75N-(4-Carbethoxyphenyl)retinamide .................... 75Carbetocin Acetate .................................................. 75S-(-)-Carbidopa monohydrate ............................... 75Carbimazole ............................................................. 76Carboplatin .......................................................... 4, 76Carmofur .................................................................. 76Carmustine .......................................................... 4, 76L-Carnitine .............................................................. 76L-Carnitine HCI ..................................................... 76L-Carnitine tartrate ................................................ 76Carnosic acid, 90 % ................................................. 76Carnosol ................................................................... 76b-Carotene ................................................................ 77Carprofen............................................................29, 77Carrageenan Sodium .............................................. 77Carvedilol ................................................................. 77Carveol ...................................................................... 77Casein Kinase 2 Assay Kit ...................................... 77b-Casomorphin, human ......................................... 77Caspase 3, Substrate, Colorimetric ....................... 77Castanospermine ..................................................... 77Catch-Relaxing Peptide (CARP) ........................... 78Catechin, 90 % ......................................................... 78Catechin, 99 % ......................................................... 78Catharanthine base.................................................. 78Catharanthine sulfate .............................................. 78Catharanthine tartrate ............................................ 78CB-TH ...................................................................... 78CCNU ....................................................................... 78CEA (605-613) ......................................................... 78CEA (605-613) analogue ........................................ 78Cecropin B ................................................................ 78Cediranib ............................................................29, 79CEF3 .......................................................................... 79CEF4 .......................................................................... 79CEF6 .......................................................................... 79CEF10 ........................................................................ 79Cefaclor ..................................................................... 79Cefoperazone Acid .................................................. 79Cefoperazone Sodium ............................................ 79Cefotaxime Acid ...................................................... 79


Cefotaxime Sodium................................................. 80Ceftazidime .............................................................. 80Ceftiofur hydrochloride .......................................... 80Ceftriaxone Sodium ................................................ 80Cefuroxime Sodium Salt ........................................ 80a-Cembrenediol ...................................................... 80b-Cembrenediol....................................................... 80b-Cembrenediol methyl ester ................................ 80Cepharanthine, 98% ................................................ 81Ceramide-C16 .......................................................... 81Cerebellin ................................................................. 81Cerivastatin .............................................................. 81Cerulenin .................................................................. 81Cetirizine .................................................................. 81Cetrimide .................................................................. 81Cetrorelix Acetate .................................................... 81b-CGRP, human ...................................................... 82Chalcone 97% ...................................................14, 82Chartreusin .............................................................. 82Cheirolin, 98% ......................................................... 82Chelerythrine Chloride .......................................... 82Chenodeoxycholic Acid .......................................... 82Chlorambucil ........................................................... 82Chloramphenicol ..................................................... 82Chloramphenicol Levo ........................................... 82Chlormadinone Acetate ........................................ 83Chlormethine ........................................................... 83Chloroadenosine ..................................................... 83Chlorogenic Acid ..................................................... 83Chlorogenic acid (from Eucommia Bark)............ 83Chlorophyllin ........................................................... 83Chloroquine Phosphate .......................................... 83Chlorpheniramine Maleate .................................... 83Chlorpromazine....................................................... 84Chlortetracycline Hydrochloride .......................... 84Cholecalciferol ......................................................... 84Cholesterol ............................................................... 84Cholinesterase & Apoptosis Assay ........................ 84Chondroitin sulfate, bovine ................................... 84Chondroitin sulfate, chicken .................................. 84Chromium picolinate .............................................. 84Chromomycin A3 .................................................... 85Chromostatin, bovine ............................................. 85Chrysin ..............................................................14, 85Chrysophanol ......................................................... 85Chymostatin ............................................................. 85Ciclopirox Olamine ................................................. 85Ciglitazone ..........................................................18, 85Cilnidipine ................................................................ 85Cilostazol .................................................................. 86Cimetidine ................................................................ 85Cinnarizine ............................................................... 86Ciprofibrate .............................................................. 86Ciprofloxacin ......................................................16, 86Ciprofloxacin Hydrochloride ...........................16, 86Cisatracurium Besylate ........................................... 86Cisplatin ..........................................................4, 26, 86Citalopram Hydrobromide ..............................18, 87

Citreoviridin A ......................................................... 87Citrinin ..................................................................... 87L-Citrulline ............................................................... 87CKS-17 ...................................................................... 87Cladribine ................................................................. 87Clarithromycin ........................................................ 87Clenbuterol Hydrochloride ..............................24, 87Climbazole ................................................................ 87Clinafloxacin Hydrochloride ................................. 88Clindamycin Hydrochloride .................................. 88Clindamycin Palmitate HCl .................................. 88Clindamycin Phosphate .......................................... 88Clobetasol Propionate ............................................. 88Clodronate Disodium ............................................. 88Clofarabine ............................................................... 88Clofibrate .................................................................. 88Clofibric acid ............................................................ 88Clomiphene Citrate ................................................. 89Clonidine HCl .......................................................... 89Clopidogrel Sulfate .................................................. 89Clopidol .................................................................... 89Closantel Sodium .................................................... 89Clotrimazole ............................................................. 89Cloxacillin sodium .................................................. 89Clozapine .................................................................. 89Clozapine N-Oxide ................................................. 90C-Myc Peptide ......................................................... 90CNP-22,human, porcine, rat .................................. 90Colchicine, 97 % ...................................................... 90Colistin sulphate ...................................................... 90Collagen Binding Fragment ................................... 90Concanavalin A ....................................................... 90a-Conotoxin GI ....................................................... 90a-Conotoxin IMI .................................................... 90Copper bis-3,5-diisopropylsalicylate .................... 91Corazonin ................................................................. 91Cordycepin ............................................................... 91Corticosterone ......................................................... 91Corticotropin Releasing Factor, bovine ................ 91Corticotropin-Releasing Factor, human, rat ........ 91Corticotropin Releasing Factor, ovine .................. 91Cortistatin-14, (rat) ................................................. 91Coumarin ................................................................. 92Coumestrol ............................................................... 92C-Peptide, dogs ........................................................ 92C-Peptide, human ................................................... 92CREBtide .................................................................. 92Cromolyn sodium ................................................... 92Crotamiton ............................................................... 92Croton Oil ................................................................ 92Crotalus durissus terrificus .................................... 92Crustacean Cardioactive Peptide, CCAP .............................................................. 92Crytotanshinone ...................................................... 92Crystalline ................................................................ 93CTAP ......................................................................... 93C-telopeptide ........................................................... 93CTX IV (6-12) ......................................................... 93


[Arg3,14] CTX IV (3-14) ....................................... 93C-Type Natriuretic Peptide (1-22), human .......... 93C-Type Natriuretic Peptide, chicken..................... 93Cuelure ...................................................................... 93Curcumin ...........................................................10, 93CV-65 ........................................................................ 93CV-66 ........................................................................ 93CV-70 ........................................................................ 94Cyanopeptolin 1007 (“CYP 1007”) .................31, 94Cyanopeptolin 1041 (“CYP 1041”) .................31, 94Cyclocytidine hydrochloride ................................. 94Cycloheximide, ≥96% ............................................. 94Cyclopamine ............................................................ 94Cyclophosphamide monohydrate .................... 4, 94Cyclopiazonic acid .................................................. 94D-Cycloserine ......................................................... 95Cyclosporin A ....................................................19, 95Cyclosporin B ........................................................... 95Cyclosporin C ......................................................... 95Cyclosporin D .......................................................... 95Cyclosporin H ......................................................... 95Cyclovirobuxine D ................................................. 95Cypermethrin .......................................................... 95Cyproconazole ...................................................16, 95Cyproterone Acetate ............................................... 96Cyromazine .............................................................. 96Cysteamine hydrochloride ..................................... 96L-Cystine .................................................................. 96Cytarabine ................................................................ 96Cytisine ..................................................................... 96Cytochalasin A ......................................................... 96Cytochalasin B ......................................................... 96Cytochalasin C ......................................................... 97Cytochalasin D......................................................... 97Cytochalasin E ......................................................... 97Cytotoxicity Test Kit ................................................ 97

D ................................................................................ 97Dacarbazine .............................................................. 97DAGO ....................................................................... 97Daidzein ..............................................................14, 97Daidzin...................................................................... 97D-Ala-D-Ala ............................................................ 97Danazol ..................................................................... 97Danofloxacin ............................................................ 98Dansyl-Y-V-G .......................................................... 98Dantrolene sodium ................................................. 98Dapiprazole Hydrochloride ................................... 98Daptomycin .............................................................. 98Darifenacin Hydrobromide ..............................21, 98Dasatinib Monohydrate .......................................... 98Daunorubicin Hydrochloride ................................ 98Deferasirox ............................................................... 98Deflazacort ............................................................... 99Dehydrocostus Lactone .......................................... 99Dehydroepiandosterone ......................................... 995,6-Dehydrokawain ................................................. 99Delta Sleep Inducing Peptide ................................. 99

Deltorphin 1 ............................................................. 99Demeclocycline Hydrochloride ............................. 99Demecolcine............................................................. 994’-Demethylepipodophyllotoxin ........................... 99L-Deoxyalliin ........................................................ 1002-Deoxy-D-glucose ............................................... 100Deoxynivalenol ...................................................... 100Deoxynivalenol, 3-Acetyl- .................................... 100Deoxynivalenol, 15-acetyl-................................... 100Dermaseptin I ........................................................ 100Dermenkephalin .................................................... 100Dermorphin .......................................................... 100Dermorphin Analog ............................................. 101Desloratadine ........................................................ 101Deslorelin Acetate ................................................. 101Desmopressin ........................................................ 101Desmopressin Acetate ........................................... 101Desoxypeganine hydrochloride .......................... 101Dexamethasone ..................................................... 101Dexamethasone Acetate ....................................... 101Dexamethasone Sodium Phosphate ................... 101Dexibuprofen ......................................................... 101Dextromethorphan Hydrobromide .................... 102Diacetoxyscirpenol ................................................ 102Diacerein ................................................................ 102Diallyl disulfide ...................................................... 102Diallyl sulfide, 97% .........................................11, 102Diallyl trisulfide ..............................................11, 102Diaveridine ............................................................ 102Diaveridine HCI ................................................... 102Dibenzoylmethane ................................................ 1032,5-Di-tert-butyl-4-hydroxyanisole .................... 103Diclazuril ......................................................... 103Diclofenac, Sodium Salt ........................................ 103Didanosine ............................................................ 1032’,3’-Dideoxycytidine ............................................ 1032’,3’-Dideoxyinosine .............................................. 103Diethylstilbestrol ................................................... 103Difenoconazole ................................................16, 103Difloxacin .........................................................16, 104Diflubenzuron ........................................................ 104Diflunisal ................................................................ 1043,4 Difluorobenzocurcumin................................. 104Difluoromethylornithine ...................................... 104Dihydrocytochalasin B ......................................... 104Dihydrokainic acid ................................................ 1047,8-Dihydrokawain ................................................ 104Dihydromethysticin .............................................. 105Dihydromyristicin ................................................. 105a,b-Dihydroresveratrol ........................................ 105Dihydrotanshinone ............................................... 1051-(2,4-Dihydroxy-6-methoxy-phenyl)-3-hydroxy-3-(4-methoxy-phenyl)-propan-1-one................. 1051-(2,4-Dihydroxy-6-methoxy-phenyl)-3-hydroxy-3-phenyl-propan-1-one ........................................ 1053,4-Dihydroxyphenyl Ethanol ............................. 1053,3’-Diindolylmethane ...................................11, 105Diltiazem ................................................................ 105


11,12-Dimethoxydihydrokawain......................... 1064-Dimethylaminopyridine ................................... 1061,1-Dimethylbiguanide Hydrochloride .............. 106Diminazene Aceturate .......................................... 106Diosgenin ............................................................... 106Diosmetin ............................................................... 106Diosmin .................................................................. 106Diphenhydramine hydrochloride ....................... 106Dipropyl disulfide .................................................. 106Dipropyl sulfide ...............................................11, 107Dipyridamole ......................................................... 107Disodium Cycloheptylaminomethylene diphosphate .................................................. 107Disulfiram ............................................................... 1073H-1,2-dithiole-3-thione ...................................... 10717-DMAG ............................................................... 107DMSA (Meso-2,3-dimercaptosuccinic acid) ..... 107Dobutamine Hydrochloride................................. 107Docetaxel ................................................................ 1082-n-Dodecylfuran .................................................. 108Dolasetron .............................................................. 108Domperidone ......................................................... 108Donepezil hydrochloride ...................................... 108Dopamine Hydrochloride .................................... 108Doramapimod ........................................................ 108Doripenem hydrate ............................................... 108Doxapram Hydrochloride Hydrate ..................... 108Doxazosin Mesylate .............................................. 109Doxifluridine ......................................................... 109Doxofylline ............................................................ 109Doxorubicin Hydrochloride ................................ 109Doxycycline Hyclate .............................................. 109Doxycycline Monohydrate ................................... 109Droloxifene ............................................................. 109Droloxifene citrate ................................................. 110DTX-4 ..................................................................... 110DU-14 ..................................................................... 110

E ............................................................................... 110Ebastine................................................................... 110Ebselen ................................................................... 110b-Ecdysone ............................................................. 110Ecdysterone ............................................................ 110Egg Laying Hormone of Aplysia .......................... 110Elcatonin Acetate ................................................... 111Eledoisin ................................................................. 111Eledoisin Related Peptide ..................................... 111Eletriptan Free Base .............................................. 111Ellagic acid.............................................................. 111Emamectin B1 Benzoate ....................................... 111Emodin ................................................................... 111Enalapril ...........................................................25, 111Enalapril Maleate ................................................... 111Enalaprilat .............................................................. 112Endomorphin-1 ..................................................... 112Endomorphin-2 ..................................................... 112Endonuclease Antigenic Site ................................ 112a-Endorphin .......................................................... 112

Acetyl, a-Endorphin .............................................. 112a-Endorphin, camel .............................................. 112a-Endorphin, human............................................ 112a-Endorphin, rat ................................................... 112Endothelin-1, human ............................................ 112Endothelin-2, human ............................................ 112Endothelin-3, human ............................................ 113Enfuvirtide (T-20) ................................................. 113Leu-Enkephalin ..................................................... 113Met-Enkephalin ..................................................... 113Met-Enkephalin, amide ........................................ 113Enocitabine ............................................................. 113Enoxacin ................................................................. 113Enoxolone ............................................................... 113Enrofloxacin .....................................................16, 113Entacapone ............................................................. 113Entecavir ................................................................. 113Enterostatin, human .............................................. 114Enterostatin, porcine, rat ...................................... 114Entinostat .........................................................30, 114(-)Epicatechin ........................................................ 114(-)Epicatechin gallate ............................................ 114(-)Epigallocatechin ..........................................14, 114Epigallocatechin gallate ....................................... 114(-)-Epinephrine ...................................................... 114Epirubicin Hydrochloride .................................... 114Epoxiconazole ..................................................16, 115Eprinomectin ......................................................... 115Eptifibatide ............................................................. 115(+-) Equol ............................................................... 115Erdosteine ............................................................... 115Ergosterol ................................................................ 115Erlotinib Hydrochloride .................................24, 115Erucin ...................................................................... 115Erysolin ................................................................... 116Erythromycin ........................................................ 116Erythromycin Ethylsuccinate ............................... 116Erythromycin Thiocyanate ................................... 116Erythromycin resistance peptide MRLFV ......... 116Erythropoietin ....................................................... 116Esculetin ................................................................. 116Esculin .................................................................... 116Esomeprazole potassium ................................27, 116Estradiol .................................................................. 117Estramustine .......................................................... 117Estramustine phosphate sodium ......................... 117Estriol ...................................................................... 117Estrone .................................................................... 117Ethacridine Lactate Monohydrate ....................... 117Ethambutol ............................................................. 117Ethisterone.............................................................. 117Ethoxyquin ............................................................. 11817-a-Ethynylestradiol ........................................... 118Etidronate Disodium ............................................ 118Etodolac ............................................................17, 118Etoposide ..........................................................15, 118Etoposide Phosphate ............................................. 118Etretinate ................................................................ 118


Everolimus .............................................................. 118Evodiamine ............................................................ 119Exemestane ............................................................. 119Exendin-3 ............................................................... 119Exendin-4 ............................................................... 119Exendin (9-39) ....................................................... 119Ezetimibe ................................................................ 119

F ............................................................................... 119FAM FLICA™: ......................................................... 119 Poly Caspases Assay Kit ..................................... 119 Caspase 1 Assay Kit .......................................... 119 Caspase 2 Assay Kit .......................................... 119 Caspase 6 Assay Kit .......................................... 119 Caspase 8 Assay Kit .......................................... 119 Caspase 9 Assay Kit .......................................... 120 Caspase 10 Assay Kit ........................................ 120 Caspase 13 Assay Kit ........................................ 120FAM-Phe-CMK FLISP™ Assay Kit ...................... 120FAM-Lys-CMK FLISP™ Assay Kit ....................... 120FAM-Leu-CMK FLISP™ Assay Kit ...................... 120FAM-Spacer-Phe-CMK FLISP™ Assay Kit ......... 120FAM-Spacer-Leu-CMK FLISP™ Assay Kit ......... 120FAM-Leu-DAP FLISP™ Assay Kit ....................... 120Famciclovir ............................................................. 120Famotidine ............................................................. 120Farnesol ................................................................... 120Fasudil Hydrochloride ....................................31, 121Febuxostat............................................................... 121Felodipine ............................................................... 121Fenbendazole ......................................................... 121Fenbufen ................................................................. 121Fenofibrate .............................................................. 121Fenoldopam mesylate ........................................... 121Fenoprofen ............................................................. 121Fenretinide ............................................................. 121Fenticonazole ......................................................... 121Ferulic acid .......................................................10, 122Ferulic Acid Methyl Ester ..................................... 122Fexofenadine Hydrochloride ............................... 122Fibrinogen-binding Peptide ................................. 122Fibrinogen gamma-chain dodecapeptide .......... 122Fibrinolysis Inhibiting Factor .............................. 122Fibrinopeptide B, human ..................................... 122Fibronectin-Binding Protein................................ 122Fibronectin CS-1 Peptide ..................................... 122Finasteride .............................................................. 122Fingolimod Hydrochloride .................................. 122Fisetin ...................................................................... 123FK506 ...................................................................... 123Flag Peptide ............................................................ 123Flavanone................................................................ 123Flavokawain A........................................................ 123Flavokawain B ........................................................ 123Fleroxacin ............................................................... 123Florfenicol .............................................................. 123Floxuridine ............................................................. 123Flubendazole .......................................................... 123

Fluconazole ......................................................16, 123Fludarabine............................................................. 124Fludarabine Phosphate ......................................... 124Flufenamic acid ................................................17, 124FluM1 A2 (58-66) .................................................. 124Flumazenil .............................................................. 124Flumequine Sodium .............................................. 124Fluocinolone Acetonide........................................ 1245-Fluorouracil ........................................................ 124Fluoxetine hydrochloride ...............................20, 124Fluophenazine ........................................................ 125Flupirtine Maleate ...........................................18, 125Flurbiprofen .......................................................... 125Flutamide ............................................................3, 125Fluticasone Propionate ......................................... 125Flutriafol ................................................................. 125Fluvastatin sodium .........................................26, 125Fluvoxamine Maleate ............................................ 125Fmoc-Lys(Boc)-Leu-Lys(Boc) ............................ 125F-M-R-F .................................................................. 125FMRF amide ......................................................... 126FMRF-like peptide from Snail ............................. 126Folic Acid ................................................................ 126Folinic Acid Calcium Salt (Leucovorin) ............. 126Forchlorfenuron (KT-30) ..................................... 126Formestane ............................................................. 126Formononetin ..................................................14, 126Formoterol Fumarate ............................................ 126N-Formyl-Met-Ala-Ser ......................................... 126N-Formyl-Met-Leu-Phe ....................................... 126N-Formyl-Met-Leu-Phe-Lys ................................ 127N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys ................. 127Forskolin ................................................................. 127Foscarnet Sodium .................................................. 127Fosfomycin Calcium ............................................. 127Fosinopril sodium ................................................. 127Fotemustene ........................................................... 127Ftorafur ................................................................... 127Fulvestrant .............................................................. 127Fumagillin .............................................................. 127Fumonisin B1 ......................................................... 128Fumonisin B2 ......................................................... 128Furosemide ............................................................. 128Fusarenon X ........................................................... 128

G .............................................................................. 128G250.A2 .................................................................. 128g-amino butyric acid, GABA ............................... 128Gabapentin .......................................................21, 128Gabexate mesylate ................................................. 128Galactosamine hydrochloride .............................. 128Galanin, human ..................................................... 128Galanin, porcine .................................................... 129Galanin, rat ............................................................. 129Galanthamine Hydrobromide ............................. 129Galantide ................................................................ 129Gallic acid ............................................................... 129(-)-Gallocatechin ................................................... 129


Gallocatechin Gallate ............................................ 129Ganciclovir ............................................................ 129Gastric Inhibitory Peptide (GIP), human .......... 129Gastrin I, human .................................................. 129Gastrin, chicken ..................................................... 130Gastrin-1, rat .......................................................... 130Gastrin Releasing Peptide, human ...................... 130Gastrin Releasing Peptide, procine ..................... 130Gatifloxacin ......................................................16, 130G-A-Y ...................................................................... 130Gefitinib ............................................................24, 130Geldanamycin ........................................................ 130Gemcitabine Hydrochloride ............................5, 130Gemfibrozil ............................................................ 130Genipin ................................................................... 131Geniposide ............................................................. 131Genistein ..........................................................14, 131Genistin .................................................................. 131Gentamycin sulfate ................................................ 131Geranylgeraniol ..................................................... 131Gestrinone .............................................................. 131G-F-R ...................................................................... 131Ghrelin, human...................................................... 131Ghrelin, rat ............................................................. 132GHRF (1-44), human ............................................ 132GHRF, rat ................................................................ 133GHRF, bovine ......................................................... 132GHRF, ovine ........................................................... 132GHRF, mouse ......................................................... 132GHRP-2 .................................................................. 132GHRP-6 .................................................................. 132Ginkgolic acid (13:0) ............................................. 132Ginkgolic acid (15:1) ............................................. 132Ginkgolic acids Mixture ....................................... 132Ginkgolide A ......................................................... 133Ginkgolide B ......................................................... 133Ginkgolide AB ...................................................... 133Ginkgolide C ......................................................... 133Ginkgolide J ............................................................ 133Ginkgolides ........................................................... 133Ginsenoside F1 ..................................................9, 133Ginsenoside F2 ..................................................9, 134Ginsenoside F3 ..................................................9, 134Ginsenoside Rb1 ................................................9, 134Ginsenoside Rb2 ................................................9, 134Ginsenoside Rb3 ................................................9, 134Ginsenoside Rc ..................................................9, 134Ginsenoside Rd ..................................................9, 134Ginsenoside Re ..................................................9, 134Ginsenoside Rg1 ................................................9, 135Ginsenoside Rg2 ................................................9, 13520(S)-Ginsenoside Rg3 .....................................9, 135Ginsenoside Rg3 ................................................9, 135Ginsenoside Rh1 ................................................9, 135Ginsenoside Rh2 ................................................9, 13520(R)-Ginsenoside Rh2 ....................................9, 135Notoginsenoside R1 ......................................136, 188Pseudoginsenoside F11 .................................136, 211

Gliclazide ............................................................... 136Glimepiride ........................................................... 136Gliotoxin ................................................................. 137Glipizide ...........................................................21, 137Glucagon, human .................................................. 137Glucagon (19-29), human .................................... 137Glucagon-Like Peptide I (7-36), amide, human .............................................. 137GLP-1 (7-37) .......................................................... 137GLP II, human ....................................................... 137GLP II, rat ............................................................... 137[Ala19] GLP II, rat ................................................ 137Glucaric acid, calcium salt .................................... 138Glucoraphanin Potassium Salt ............................. 138Glucoraphenin Potassium Salt ............................. 138Glucosamine hydrochloride................................. 138Glucosamine sulfate .............................................. 138L-Glutamine ........................................................... 138Glycerol Monolaurate ........................................... 138Glycidamide ........................................................... 138Glycitein .................................................................. 138Glycitin ................................................................... 13918 b-Glycyrrhetinic Acid ..................................... 139Glycyrrhizic acid, ammonium salt, trihydrate .. 139Gonadorelin Acetate ............................................. 139Goserelin Acetate................................................... 139Gossypol ................................................................. 139Gossypol-acetic acid ............................................. 139gp38 ......................................................................... 139G-P-R ...................................................................... 139G-Q .......................................................................... 140Granistetron ........................................................... 140Granuliberin R ....................................................... 140Green tea polyphenols .......................................... 140Growth Hormone Releasing Factorr, Human ... 140Guaifenesin............................................................. 140Guanylin, human ................................................... 140Guanylin, rat, mouse ............................................. 140Guggulsterone ........................................................ 140

H .............................................................................. 140H7 ............................................................................ 140H8 ............................................................................ 141H89 .......................................................................... 141HA Peptide ............................................................. 141Haloperidol ......................................................21, 141Harringtonin .......................................................... 141HBV core protein (128-140) ................................ 141Helodermin ............................................................ 141Helodormin ............................................................ 141Helospectin I .......................................................... 141Helospectin II ........................................................ 142Hemorphin-7 ......................................................... 142Heparin Sodium .................................................... 142Heparin-Binding Peptide ..................................... 142Hepatitis B Virus core protein (128-140) ........... 142Heptaplatin ............................................................. 1422-n-Heptylfuran .................................................... 142


HER2/neu (869-877) ............................................. 142HER2/neu(654-662) GP2 ..................................... 142Herbimycin A......................................................... 142Hesperetin .............................................................. 142Hesperidin .............................................................. 143Hexaconazole ......................................................... 143Hexamethonium bromide hydrate ...................... 143Hexamethylene Biscetamide ................................ 143Hexarelin ................................................................ 143Hexestrol ................................................................. 143S-Hexylglutoathione ............................................. 143His Tag .................................................................... 143Histatin 5 ................................................................ 143Histrelin Acetate .................................................... 144HIV p17 Gag (77-85) ............................................ 144HIV Integrase Protein Inhibitor (1) .................... 144HIV Protease Substrate ......................................... 144HIV RT (pol) A2.1 peptide .................................. 144HMG (Human Menopausa Gonadotropins) ..... 144Homoharringtonin ................................................ 144Honokiol ................................................................. 144H-Trp-Gly-OH ...................................................... 144Human Follicular Gonadotropin Releasing Peptide ......................................... 144Humanin, human .................................................. 145Huperzine A .....................................................18, 145Hyaluronic Acid Sodium salt ............................... 145Hydrochlorothiazide ............................................. 145Hydrocortisone ...................................................... 145Hydrocortisone 21-acetate ................................... 145Hydroquinone ........................................................ 1457-Hydroxyaristolochic Acid A ............................. 14520-Hydroxyecdysone ............................................ 14617 a-Hydroxyprogesterone Caproate ................. 1462-Hydroxy-Flutamide ........................................... 146N-(4-Hydroxyphenyl)retinamide ........................ 146(Z)-4-Hydroxytamoxifen ................................10, 146(E)-4-Hydroxytamoxifen ................................10, 146(E,Z)-4-Hydroxytamoxifen ............................10, 1465-Hydroxy-L-tryptophan ..................................... 1463-Hydroxytyrosol .................................................. 146Hydroxyurea........................................................... 14625-Hydroxyvitamin D2 ........................................ 14725-Hydroxyvitamin D3 ........................................ 147Hydroxyzine Dihydrochloride ............................. 1472-Hydroxy Estradiol .............................................. 147Hyoscine Butyl Bromide ....................................... 147Hypaconitine ....................................................19, 147Hypericin ................................................................ 147Hypocrellin B ........................................................ 147Hypoxanthine ....................................................... 147

I ................................................................................ 148Ibandronate ............................................................ 148Iberin ....................................................................... 148Iberverin ................................................................. 148Ibudilast .................................................................. 148Ibuprofen ............................................................... 148

S(+) Ibuprofen ....................................................... 148Icariin ................................................................15, 148Idarubicin Hydrochloride .................................... 148Idebenone ............................................................... 149Idoxuridine ............................................................. 149Ifosfamide ............................................................. 149Ikarugamycin ......................................................... 149Iloperidone ............................................................. 149Imatinib mesylate ............................................24, 149Imazalil ................................................................... 149Imipenem ............................................................... 149Imiquimod ............................................................. 150Imperatorin ............................................................ 150Isoimperatorin ....................................................... 150Incadronate ............................................................ 150Indapamide ............................................................ 150Indinavir Sulfate .................................................... 150Indole-3-carbinol .............................................11, 150Indolicidin .............................................................. 150Indomethacin ......................................................... 150Iniparib .............................................................30, 151Inositol .................................................................... 151Inositol hexaphosphate ......................................... 151Interleukin-6 Receptor (partial) .......................... 151Iohexol .................................................................... 151Ionomycin free acid ............................................... 151Ionomycin (Calcium Salt) .................................... 151Ipriflavone ............................................................. 151Irbesartan................................................................ 151Irinotecan ............................................................... 152Irinotecan Hydrochloride Trihydrate ................. 152Irsogladine Maleate ............................................. 152Isatin ...................................................................... 152Isobavachalcone ..................................................... 152Isoniazid ................................................................. 152Isopropyl Thiogalactoside .................................... 153Isoproterenol Hydrochloride ............................... 153Isorhamnetin .......................................................... 153Isoquinolinesulfonyl-2-methylpiperazine .......... 153Isosorbide Mononitrate ........................................ 1531-Isothiocyanato-7-(methylsulfenyl)-heptane .. 1531-Isothiocyanato-6-(methylsulfenyl)-hexane .... 1531-Isothiocyanato-9-(methylsulfenyl)-nonane ... 1531-Isothiocyanato-8-(methylsulfenyl)-octane ..... 1531-Isothiocyanato-7-(methylsulfinyl)-heptane ... 1531-Isothiocyanato-6-(methylsulfinyl)-hexane ..... 1541-Isothiocyanato-9-(methylsulfinyl)-nonane .... 1541-Isothiocyanato-8-(methylsulfinyl)-octane ..... 1541-Isothiocyanato-7-(methylsulfonyl)-heptane .. 1541-Isothiocyanato-6-(methylsulfonyl)-hexane .... 1541-Isothicyanato-9-(methylsulfonyl)-nonane ..... 1541-Isothicyanato-8-(methylsulfonyl)-octane ....... 154Isotretinoin ............................................................. 154Itopride Hydrochloride ...................................21, 154Itraconazole ......................................................16, 154Ivermectin ........................................................21, 155


K ............................................................................... 155K252A ...............................................................23, 155K252B ................................................................23, 155K252C ..................................................................... 155KT5720 .............................................................23, 155KT5823 .............................................................23, 155Kaempferol, 95% .................................................... 155Kahweol ............................................................12, 156Kahweol acetate ..................................................... 156Kahweol eicosanate ............................................... 156Kahweol linoleate .................................................. 156Kahweol oleate ....................................................... 156Kahweol palmitate ................................................. 156Kahweol stearate .................................................... 156Kainic Acid ............................................................. 156Kallikrein Inhibitor ............................................... 156Kanamycin A .......................................................... 156Kanamycin B .......................................................... 157Kassinin .................................................................. 157Katacalcin ............................................................... 157Kavalactones Mixture ........................................... 157Kawain .................................................................... 157Kemptide ................................................................ 157Kendomycin ........................................................... 157Kenpaullone ........................................................... 157Ketanserin .............................................................. 157Ketoconazole ....................................................16, 158Ketolide resistance Peptide MRFFV ................... 158Ketoprofen .............................................................. 158Ketorolac Tromethamine...................................... 158Ketotifen Fumerate ............................................... 158Kinetensin .............................................................. 158KL-1 ......................................................................... 158K-R-Q-H-P-G ........................................................ 158Kyotorphin ............................................................. 159

L ............................................................................... 159Lactacystin .............................................................. 159Lactalbumin ........................................................... 159Lactoferrin (Bovine) ............................................. 159Lactulose ................................................................. 159Lagochiline ............................................................. 159Laminin peptide YIGSR ....................................... 159Laminin peptide YIGSR-NH2 ............................. 159Laminin peptide SIKVAV ..................................... 159Laminin peptide CDPGYIGSR............................ 159Lamivudine ............................................................ 160Lamotrigine ............................................................ 160Lansoprazole ....................................................27, 160Lapatinib Ditosylate .............................................. 160Lappaconitine ..................................................19, 160Latrunculin A ...................................................22, 160Lavendustin A ........................................................ 160Leflunomide ........................................................... 161Ac-LEHD-PNA ...................................................... 161Leptin (22-56), human .......................................... 161Leptin (116-130), mouse ...................................... 161Leptomycin B ......................................................... 161

Letrozole ................................................................. 161Leucokinin I ........................................................... 161Leucokinin VIII ..................................................... 161Leucomyosuppressin (1ms) ................................. 161Leucovorin Calcium .............................................. 162Leuprolide Acetate Salt ......................................... 162Levamisole Hydrochloride ................................... 162Levetiracetam ......................................................... 162Levitide ................................................................... 162Levocetirizine Dihydrochloride .......................... 162Levodopa ................................................................ 162Levofloxacin Hydrochloride ..........................16, 162Levonorgestrel ....................................................... 162Levosimendan ....................................................... 163Levothyroxine Sodium ......................................... 163D-Limonene ........................................................... 163Limonin ................................................................. 163Limonin Glucoside ................................................ 163Lincomycin Hydrochloride .................................. 163Linezolid ................................................................. 163D,L-a-Lipoic acid .................................................. 163b-Lipotropin (61-64) ............................................. 164Lisinopril ..........................................................25, 164Litorin ..................................................................... 164Lofexidine Hydrochloride .................................... 164Lomefloxacin Hydrochloride ............................... 164Lomeguatrib ........................................................... 164Lomerizine Hydrochloride ................................... 164Lomustine ............................................................. 164Lonidamine ........................................................... 164Loperamide Hydrochloride ................................ 165Lopinavir ................................................................ 165Loratadine ............................................................. 165Lorglumide Sodium .............................................. 165Lornoxicam ............................................................ 165Losartan Potassium ............................................... 165Lovastatin .........................................................26, 165Loxoprofen ............................................................. 165Lumaricoxib .....................................................17, 166Lupinine .................................................................. 166Luteinizing Hormone Releasing Hormone ........ 166LH-RH, salmon ..................................................... 166[Gln8] LH-RH, chicken ........................................ 166Luteinizing Hormone Releasing Hormone-III, Lamprey ............................... 166Luteolin ................................................................... 166Lycopene .........................................................13, 166Lys(Boc)-Leu-Lys(Boc)-Obzl .............................. 166L-(+)Lysine Monohydrate .................................... 167Lysipressin Acetate ................................................ 167

M .............................................................................. 167M35 ......................................................................... 167M40 ......................................................................... 167Madecassic acid ..................................................... 167Magainin 1 .............................................................. 167Magainin 2 .............................................................. 167MAGE-3 Antigen (271-279), human .................. 167


Magic Red TM Caspases 3 & 7 Assay Kit ........... 167Magic Red TM Cathepsin B Assay Kit ............... 167Magic Red TM Cathepsin K Assay Kit ............... 168Magic Red TM Cathepsin L Assay Kit ................ 168Magnolol ................................................................. 168Malantide ................................................................ 168Manidipine Hydrochloride .................................. 168Manzamine A ...................................................22, 168Maprotiline Hydrochloride .................................. 168Mas7 ........................................................................ 168Mas8 ........................................................................ 168Mas17 ...................................................................... 169Masitinib ................................................................. 169Mast Cell Degranulating Peptide ........................ 169Mastoparan ............................................................. 169Mastoparan X ......................................................... 169Matrine ................................................................... 169Mebendazol ............................................................ 169Mecamylamine Hydrochloride ............................ 169Medoxyprogesterone 17-Acetate ......................... 169Mefenamic acid ...................................................... 170Megestrol Acetate ................................................. 170Meglumine ............................................................. 170Melanin Concentrating Hormone, human, mouse, rat ....................................... 170Melanin Concentrating Hormone, salmon ........ 170a-Melanocyte stimulating hormone ................... 170b-Melanocyte stimulating hormone, human ..... 170[Nle4,D-Phe7] a-Melanocyte, stimulating hormone................................... 170g 1-Melanocyte stimulating hormone ................. 170g 3-Melanocyte stimulating hormone ................. 170Melanoma-associated antigen peptide MART-1(27-35), human ............................ 171Melanostatin, frog ................................................. 171Melanotan II ........................................................... 171Melatonin ............................................................... 171Melittin ................................................................... 171Meloxicam .............................................................. 171Memantine hydrochloride ................................... 171Men 10376 .............................................................. 1716-Mercaptopurine Monohydrate ......................... 171Meropenem ............................................................ 172Mesalamine ............................................................ 172MESNA (2-Mercaptoethanesulfonic Acid) ........ 172Metformin Hydrochloride .............................18, 172Methimazole .......................................................... 172Methotrexate .......................................................... 1722-Methoxy estradiol .............................................. 1725-Methoxyindole ................................................... 17211-Methoxyyangonin ............................................ 172a -Methylbenzyl isothiocyanate .......................... 173R (-) a-Methylbenzyl isothiocyanate (D) ........... 173S (+) a-Methylbenzyl isothiocyanate (L) ............ 173Methyl Caffeate ................................................10, 173S-Methyl-L-Cysteine-S-Oxide ............................. 173Methyldopa Sesquihydrate ................................... 173Methylhesperidin .................................................. 173

Methylprednisolone .............................................. 173Methyl Salicylate .................................................... 173S-(N-Methylsulfinylbutylthiocarbamoyl)- glutathione ................................................8, 174S-(N-Methylthiocarbamoyl)-L-cysteine ............. 174Methysticin ............................................................. 174Metoprolol Tartrate ............................................. 174Metronidazole ........................................................ 174Mevastatin .............................................................. 174Mevinolin ............................................................... 174Melphalan ............................................................... 174MGP-pNA .............................................................. 174Miconazole. ....................................................16, 175Miconazole Nitrate ................................................ 175Microcystin LR, desmethyl (“Asp3-MCLR”) ....31, 175Microcystin (N-methyl-L)R (“MC(N-Me)LR”) ..... 175Microginin 527 ...................................................... 175Microginin 690 ...................................................... 175Microginin 704 ...................................................... 175Microginin 527 methyl ester ................................ 175Microginin 690 methyl ester ................................ 176MIF-1 Tyr ............................................................... 176Tyr-W-MIF-1 ......................................................... 176Mifepristone ........................................................... 176Milrinone ................................................................ 176Minocycline Hydrochloride ................................. 176Minoxidil ................................................................ 176Mirtazapine ............................................................ 176Mithramycin .......................................................... 177Mitiglinide Calcium .............................................. 177Mitomycin C .......................................................... 177MitoPT™ Kit ........................................................... 177Mitotane .................................................................. 177Mitoxantrone Dihydrochloride ........................... 177Mivacurium ............................................................ 177Mizoribine Hydrobromide ................................... 177Moguisteine ............................................................ 177Molsidomine .......................................................... 177Monastrol ............................................................... 178Monensin Sodium Salt .......................................... 178Moniliformin ......................................................... 178Montelukast Sodium ............................................. 178Motesanib .........................................................21, 178Motilin, canine ....................................................... 178Motilin, porcine ..................................................... 178Moxifloxacin Hydrochloride ..........................16, 178Mubritinib, Free base ............................................ 178Myclobutanil .......................................................... 179Mycophenolic acid ..........................................26, 179Myelin basic Protein (1-11), human ................... 179Myelin Basic Protein (87-99), guinea pig, human ....................................... 179Myelin Basic Protein (68-82), guinea pig ........... 179Myelin Oligodendrocyte Glycoprotein (35-55), rat ............................ 179Myomodulin .......................................................... 179Myricetin ................................................................ 179Myriocin ................................................................. 179


Myristicin ............................................................... 179

N .............................................................................. 179Nabumetone ........................................................... 179Nadifloxacin .....................................................16, 180Naftopidil ................................................................ 180Naphazoline Hydrochloride ................................. 180Naphazoline Nitrate .............................................. 180b-Naphthoflavone .................................................. 180NAP ......................................................................... 1802-(1,8-Naphthyridin-2-ly)phenol ........................ 180D-Naproxen............................................................ 180D,L-Naproxen ........................................................ 180Naringenin ............................................................. 181Naringin .................................................................. 181Natamycin .............................................................. 181Nedaplatin .............................................................. 181Nefazodone Hydrochloride .................................. 181Nefiracetam ............................................................ 181Nelarabine .............................................................. 181Neomycin sulfate ................................................... 182Neopterin ................................................................ 182Neosolaniol............................................................. 182Neostigmine Bromide ........................................... 182Nerolidol ................................................................. 182Nesiritide Acetate (BNP-32) ................................ 182Netilmicin Sulfate .................................................. 182Neurokinin A (4-10) ............................................. 182Neurokinin B.......................................................... 182Neuromedin ........................................................... 183Neuromedin B, porcine ........................................ 183Neuromedin C, porcine GRP (18-27) ................ 183Neuromedin U, rat ................................................ 183Neuropeptide FF F-8-F-NH2 ............................... 183Neuropeptide K, porcine ...................................... 183Neuropeptide Y (3-36), human ........................... 183Neuropeptide Y (13-36), human ......................... 183Neuropeptide Y, human, rat ................................. 183g-Neuropeptide, rabbit .......................................... 183Neurotensin ............................................................ 183[Gln4] Neurotensin ............................................... 184[D-Trp11]-Neurotensin ........................................ 184Neurotensin (1-11) ................................................ 184Neurotensin (9-13) ................................................ 184Neurotensin (frog) ................................................ 184Neurotensin, guinea pig........................................ 184Niacin ...................................................................... 184Nicardipine ............................................................. 184Nicotinamide ......................................................... 184Nidulal .................................................................... 184Nifidepine ............................................................... 185Nifekalant Hydrochloride .................................... 185Niflumic acid ....................................................17, 185Nifuratel .................................................................. 185Nifursol ................................................................... 185Nigericin ................................................................. 185Nilotinib ............................................................24, 185Nimesulide .......................................................17, 185

Nimodipine ............................................................ 186Nimustine Hydrochloride .................................... 1867-Nitroindazole ...................................................... 186Nitroso(acetoxymethyl)methylamine ................. 186S-Nitrosoglutathione ............................................. 186Nivalenol ................................................................. 186Nizatidine ............................................................... 186Nobiletin ................................................................. 186Nociceptin .............................................................. 187Nocistatin ............................................................... 187Nocodazole ............................................................. 187Nomilin .................................................................. 187Nonactin ................................................................. 187Nonoxynol, n=9 ..................................................... 187Noradrenaline ........................................................ 187Nordihydroguaiaretic acid ................................... 187Norepinephrine bitartrate .................................... 187Norethindrone ....................................................... 188Norethisterone ....................................................... 188Norfloxacin .......................................................16, 188Norfloxacin Nicotinate ......................................... 188Norgestrel ............................................................... 188NPF.......................................................................... 188N(p-Tosyl)-GPR-pNA .......................................... 188NTB (Naltriben) .................................................... 188Nystatin ................................................................... 188

O .............................................................................. 188Ochratoxin A ......................................................... 188Octaneuropeptide .................................................. 189Octopamine HCI ................................................... 189Octreotide Acetate ................................................. 189n-Octyl Caffeate ...............................................10, 189n-Octyl-3,4-Dimethylcaffeate .............................. 189n-Octyl-3-methylcaffeate ..................................... 189n-Octyl-4-methylcaffeate ..................................... 189Ofloxacin ................................................................ 189R-(+)-Ofloxacin ..................................................... 189Ofloxacin Hydrochloride................................16, 190Okadaic Acid ....................................................22, 190Okadaic Acid Ammonium Salt .....................22, 190Okadaic acid C8 diol ester ..............................22, 190Okadaic acid methyl ester ..............................22, 190Okadaic Acid Sodium Salt..............................22, 190Okadaol ................................................................... 190Olaparib ............................................................30, 190Oleanolic Acid ....................................................... 190Oligomycin ............................................................. 191Oligomycin A ......................................................... 191Oligomycin B ......................................................... 191Olomoucine ............................................................ 191Olsalazine Sodium................................................. 191Oltipraz ................................................................... 191Omeprazole ......................................................27, 191Ondansetron .......................................................... 191Opioid receptor antagonist Ac-RFMWMK-NKH2 ................................ 192Orbifloxacin ........................................................... 192


Orexin-B, human ................................................... 192Ornidazole .............................................................. 192L-Ornithine Hydrochloride ................................. 192Orphanin FQ .......................................................... 192Oseltamivir phosphate .......................................... 192Osthole .................................................................... 192OVA(323-339)........................................................ 192Ovalbumin(257-264) antigen peptide ................ 192Oxacillin Sodium Monohydrate .......................... 193Oxaliplatin .............................................................. 193Oxcarbazepine ....................................................... 193Oxfendazole ........................................................... 193Oxibendazole ......................................................... 193Oxiconazole Nitrate .............................................. 19316-Oxocafestol ....................................................... 19316-Oxokahweol ...................................................... 193Oxolinic acid .......................................................... 194Oxybutynin HCl .................................................... 194Oxymetazoline Hydrochloride ............................ 194Oxytetracycline ...................................................... 194Oxytetracycline Hydrochloride ........................... 194Oxytocin ................................................................. 194Ozagrel HCl ............................................................ 194

P ............................................................................... 194P1 ............................................................................. 194P7C3 ........................................................................ 194P55-TNFR .............................................................. 195P75-TNFR .............................................................. 195PACAP (1-27), human, ovine, rat ....................... 195PACAP (1-38), human, ovine, rat ....................... 195PACAP (6-27), human, ovine, rat ....................... 195PACAP (6-38), human, ovine, rat ...................... 195PACAP 38, frog ...................................................... 195PACAP-Related Peptide (PRP), human ............. 195PACAP-Related Peptide (PRP), rat ..................... 195Paclitaxel, Natural (Taxol), 99% ......................... 196Paclitaxel, Semi-Synthetic .................................... 196Paeoniflorin ............................................................ 196Paeonol ................................................................... 196Paliperidone ........................................................... 196Palmatine Chloride Hydrate ................................ 196Palmitoyl-D,L-carnitine chloride ........................ 197Palmitoyl-L-carnitine chloride ............................ 197Pamidronate Disodium ....................................... 197Panaxadiol .............................................................. 197Panaxatriol .............................................................. 197Pancreatic Polypeptide, avian .............................. 197Pancreatic Polypeptide, rat ................................... 197Pancreatic Polypeptide, human ........................... 197Pancreastatin, porcine ........................................... 197Pancuronium Bromide ......................................... 198Pantoprazole ........................................................... 198Pantoprazole Sodium ............................................ 198Papain Inhibitor ..................................................... 198Parasin I .................................................................. 198Parathyroid Hormone (1-34), bovine ................. 198Paromomycin Sulfate ............................................ 198

Paroxetine Hydrochloride .................................... 198Parthenolide ........................................................... 198Patulin ..................................................................... 199Paxilline .................................................................. 199Pazopanib .........................................................29, 199Pazufloxacin Mesylate .....................................16, 199PD184352 ............................................................... 199PD325901 ............................................................... 199Pefloxacine Mesylate ............................................. 199Pemtrexed ............................................................... 200Penciclovir .............................................................. 200Penicillamine .......................................................... 200Penicillic acid ......................................................... 200Penicillin G procaine............................................. 200Penicillin V Potassium .......................................... 200Penitrem A ............................................................. 200Pentagastrin ............................................................ 200Pentoxifylline ......................................................... 200Pep-1 ....................................................................... 200Peptide Standard .................................................... 201Peptide B, bovine ................................................... 201Peptide F, bovine .................................................... 201Peptide T ................................................................. 201Peptide YY, human ................................................ 201Peptide YY, porcine ............................................... 201Peptide YY(3-36), PYY, human ........................... 201Pepstatin ................................................................. 201Perillyl Alcohol ...................................................... 201Perindopril .......................................................25, 201PGLa ........................................................................ 202Phallacidin .............................................................. 202Phalloidin ............................................................... 202Phenethyl caffeate ...........................................10, 202Phenethyl dimethyl caffeate ...........................10, 202Phenethyl glucosinolate potassium salt, 97% .... 202Phenethyl isothiocyanate, 98% ........................8, 202Phenethyl isothiocyanate N-acetyl-L-cysteine conjugate ................... 202S-(N-Phenethylthiocarbamoyl)-L-cysteine ...8, 202S-(N-Phenylbutylthiocarbamoyl)-glutathione .. 203S-(N-Phenylbutylthiocarbamoyl)-L-cysteine .8,203S-(N-Phenylthiocarbamoyl)-glutathione ........... 203Phentolamine Hydrochloride .............................. 203Phentolamine mesylate ......................................... 203L-Phenylalaninol ................................................... 203Phenylbutazone ..................................................... 2034-Phenylbutyl isothiocyanate .........................8, 203Phenylbutyrate ....................................................... 203Phenylethyl 3-methylcaffeate .............................. 204Phenylethyl 4-methylcaffeate ............................... 2046-Phenyl-hexa-3,5-dien-2-one ............................ 204Phenylhexyl isothiocyanate .................................. 204Phenyl isothiocyanate ........................................... 2043-Phenylpropyl isothiocyanate ........................8, 204S-(N-3-Phenylpropylthiocarbamoyl)- L-cysteine ...................................................... 204PHI, porcine ........................................................... 204PHI, rat ................................................................... 204


Phleomycin ............................................................. 205Phorbol-12,13-dibutyrate ..................................... 205Phorbol-12-myristate-13-acetate ........................ 2054-a-Phorbol-12-myristate-13-acetate ................ 205Phosphate Acceptor Peptide ................................ 205Phyllolitorin ........................................................... 205Phyllomedusin ....................................................... 205Physalaemin ........................................................... 205Physcion .................................................................. 205Phytic Acid, 40-50 wt% aqueous solution .......... 205Piceatannol ............................................................. 206Piceid ....................................................................... 206Picoplatin ................................................................ 206Pidotimod ............................................................... 206Pimaricin ................................................................ 206Pimecrolimus ......................................................... 206Pioglitazone hydrochloride ............................18, 206Piperacillin ............................................................. 206Piperacillin sodium ............................................... 206Piperine ...............................................................5, 207Pirarubicin .............................................................. 207Piroxicam ............................................................... 207Pitavastatin ............................................................. 207Pixantrone Dimaleate ........................................... 207Pizotyline malate .................................................. 207PKC412 ................................................................... 207Plasminogen Activator Inhibitor 1 (PAI-1) ....... 207PLP (139-151) ....................................................... 207Podophyllotoxin .................................................... 208Polydatin ................................................................. 208Potassium canrenoate ........................................... 208Povidone iodine ..................................................... 208PP1........................................................................... 208Pramipexole ........................................................... 208Pranoprofen............................................................ 208Prasugrel ................................................................. 208Pravastatin Lactone ............................................... 208Pravastatin Sodium ........................................26, 209Praziquantel............................................................ 209Prednisolone .......................................................... 209Prednisolone sodium phosphate ......................... 209Prednisone .............................................................. 209Prednisone Acetate ................................................ 209Pregnenolone ...................................................21, 209Pressinoic Acid ...................................................... 209Primaquine phosphate .......................................... 210Prion Peptide (106-126), human ......................... 210Procarbazine Hydrochloride ................................ 210Procaterol Hydrochloride ..................................... 210Proctolin ................................................................. 210Progesterone ........................................................... 210Prolactin-Releasing Peptide (1-31), human ....... 210Propafenone Hydrochloride ................................ 210Prostaglandin E1.................................................... 210Prothionamide ....................................................... 210Protocatechuic Acid .............................................. 211Protocatechuic acid ethyl ester ............................ 211Protocatechuic aldehyde ....................................... 211

Protodioscin ........................................................... 211Protopanaxadiol..................................................... 211Protopanaxatriol .................................................... 211Proxymetacaine Hydrochloride........................... 211Prulifloxacin ........................................................... 211Pseudolaric Acid B ................................................ 212Psoralen (Ficusin)............................................32, 212Psoralidin ................................................................ 212pTH-Related Protein (1-34) (human, rat) ......... 212Puerarin, 96% ......................................................... 212Puerarin, 99% ......................................................... 212Puromycin .............................................................. 212Puromycin aminonucleoside ............................... 213Purpurin ................................................................. 213Purvalanol A .......................................................... 213Puupehenone ...................................................22, 213Pyrantel Pamoate ................................................... 213Pyrazinamide ......................................................... 213Pyr-Gly-Arg-pNA.................................................. 213Pyridoxine Hydrochloride ................................... 213Pyriproxyfen ........................................................... 213Pyronaridine Tetraphosphate .............................. 214Pyrrolostatin........................................................... 214

Q .............................................................................. 214Q-K-R-P-S-Q-R-S-K-Y-L ..................................... 214Quercetin Dihydrate .....................................14, 214Quetiapine Fumarate ............................................ 214Quinacrine Dihydrochloride Dihydrate ............. 214Quinapril hydrochloride ...................................... 214Quinestrol ............................................................... 214

R ............................................................................... 214Rabeprazole ......................................................27, 214Racecadotril ........................................................... 215Racemethorphan ................................................... 215Ractopamine .......................................................... 215Radicicol ................................................................. 215Raloxifene Hydrochloride .................................... 215Raltitrexed .............................................................. 215Ramatroban ............................................................ 215Ramelteon ............................................................... 215Ramipril ............................................................25, 215Ramosetron ............................................................ 216Ranatensin .............................................................. 216Ranatensin R .......................................................... 216Ranitidene Hydrochloride.................................... 216Ranolazine Dihydrochloride ................................ 216Rapamycin .............................................................. 216Rasagiline ............................................................... 216Rebamipide............................................................. 216Recombinant HCV-Core antigens ...................... 217Recombinant HCV-NS3 antigens ....................... 217Recombinant HCV-NS4 antigens ....................... 217Recombinant HCV-NS5 antigens ....................... 217Recombinant HIV-1 gp-41 ................................... 217Recombinant HIV-1 gp-120................................. 217Recombinant HIV-1 ‘O’group consensus ........... 217


Recombinant HIV-2 gp36 .................................... 217Recombinant Multi-epitope Chimeric HCV antigen. .............................. 217Recombinant Multi-epitope Chimeric HIV antigen ................................ 217Recombinant Tp-chimeric protein ...................... 217Recombinant TpN 15 protein .............................. 217Recombinant TpN 17 protein .............................. 217Recombinant TpN 44.50 protein ......................... 217Recombinant TpN 47 protein .............................. 218Renin Inhibitor Peptide ........................................ 218Repaglinide ............................................................. 218Resiniferatoxin ....................................................... 218Resiniferonol-9,13,14-orthophenyl acetate (ROPA) ........................................... 218Resveratrol .......................................................13, 218Retigabine ............................................................... 218Retigabine Dihydrochloride ................................. 2189-cis-Retinoic acid ................................................. 21913-cis-Retinoic acid ............................................... 219trans-Retinoic acid ................................................ 219all-trans-Retinol ..................................................... 219Retinyl acetate ...................................................... 219Retinyl palmitate ................................................... 219Reveromycin A ...................................................... 219RFDS. ...................................................................... 219R-F-NH2 ................................................................. 219RFRP-1 (Human) .................................................. 220RGD. ........................................................................ 220RGD-4C .................................................................. 220R-G-D-C ................................................................. 220RGDS. ..................................................................... 220RGDV. ..................................................................... 220R-G-E-S ................................................................... 220R-G-Y-S-L-G .......................................................... 220Rhein. ...................................................................... 220Ribavirin ................................................................. 220Riboflavin ............................................................... 221Ricobendazole ........................................................ 221Ridaifen A Dihydrochloride ................................ 221Rifampin ................................................................. 221Rifamycin SV-3 formyl ......................................... 221Rifamycin SV-Sodium .......................................... 221Rifaximin ................................................................ 221Rigin ........................................................................ 221Rimantadine Hydrochloride ................................ 222Riluzole ................................................................... 222Risedronate sodium .............................................. 222Risedronic acid ...................................................... 222Risperidone ............................................................ 222Ritodrine ................................................................. 222Ritonavir ................................................................. 222Rivaroxaban............................................................ 222Rivastigmine Hydrogen Tartrate ......................... 223Rocuronium Bromide ........................................... 223Rofecoxib ..........................................................17, 223Ropinirole Hydrochloride .................................... 223Rosiglitazone Maleate ........................................... 223

Rosiglitazone ....................................................18, 223Rosmarinic Acid .................................................... 223Rosuvastatin ........................................................... 223Rotenone ................................................................. 224Roxatidine Acetate Hydrochloride ...................... 224Roxithromycin ....................................................... 224RR-SRC ................................................................... 224R-S-R ....................................................................... 224Rubescensin A........................................................ 224b-Rubromycin ........................................................ 224Rufloxacin Hydrochloride .................................... 224Rutaecarpine .......................................................... 225Rutaecarpine (synthetic) ...................................... 225Rutin Hydrate ........................................................ 225

S ............................................................................... 225S6-1 .......................................................................... 225Saikosaponin A ...................................................... 225Saikosaponin B1 .................................................... 225Saikosaponin B2 .................................................... 225Saikosaponin C ...................................................... 225Saikosaponin D ...................................................... 226Salbutamol free base.............................................. 226Salbutamol sulfate ................................................. 226Salicin ...................................................................... 226Salmon Calcitonin Acetate ................................... 226Salsalate ................................................................... 226Salsolidine ............................................................ 226Salsoline ............................................................... 226SAMs peptide ......................................................... 227a-Santonin ............................................................. 227Saracatinib .............................................................. 227Sarafloxacin Hydrochloride ................................. 227Sarafotoxin 6c......................................................... 227Sarcophine ........................................................22, 227Satraplatin ............................................................... 227Sauvagine ................................................................ 227R(+) Schisandrin A ............................................... 228S(-) Schisandrin B ................................................. 228Schisantherin A ..................................................... 228Scopolamine N-butylbromide ............................. 228Scopolamine Hydrobromide ................................ 228SCPA ....................................................................... 228SCPB........................................................................ 228Scriptaid .................................................................. 228Ac-S-D-K-P ............................................................ 229Secnidazole ............................................................. 229Secretin Acetate ..................................................... 229Secretin, human ..................................................... 229Secretin, porcine .................................................... 229Secretin, rat............................................................. 229Securinine .........................................................21, 229Sedanolide .............................................................. 229L-Selectin ................................................................ 229L-(+)-Selenomethionine ................................12, 230Se-methylseleno-L-cysteine ................................ 230Seratrodast .............................................................. 230Sermorelin Acetate ................................................ 230


Sertraline HCl ........................................................ 230Serum Thymic Factor ............................................ 230S-F-L-L-R ................................................................ 230Shikimic acid ......................................................... 230Sildenafil Citrate .................................................... 230Silodosin ................................................................. 231Silybin ..................................................................... 231Silymarin...........................................................14, 231Simvastatin ......................................................26, 231Sincalide (CCK-8) ................................................. 231Sinomenine............................................................. 231Sitagliptin Phosphate Monohydrate .................... 231Sivelestat Sodium Tetrahydrate ........................... 232SIVmac239-1 .......................................................... 232SIVmac239-2 .......................................................... 232SNA 1 ...................................................................... 232Snake venom -Bothrops alternatus (urutu) ....... 232Snake venom-Bothrops neuwiedi diporous ....... 232Snake venom - Crotalus durissus terrificus ....... 232Solanesol ................................................................. 232[Tyr1] Somatostatin .............................................. 232[Tyr11] Somatostatin ............................................ 232Somatostatin-14 ..................................................... 232Somatostatin-25 ..................................................... 233Somatostatin-28 ..................................................... 233Somatostatin-28 (1-12) ......................................... 233Somatostatin-28 (1-14) ......................................... 233Somatostatin Acetate............................................. 233Sorafenib ...........................................................29, 233Sorafenib Tosylate.................................................. 233Sotalol ..................................................................... 233Sparfloxacin ......................................................16, 233Spectinomycin Hydrochloride ............................. 233Speract ..................................................................... 234D-Sphingosine ....................................................... 234Sphingosine, N,N-dimethyl ................................ 234Sphingosine 1-phosphate ..................................... 234Spinorphin, bovine ................................................ 234Spiramycin .............................................................. 234Spiramycin Embonate ........................................... 234Spiramycin Hexanedioate ..................................... 234Spirapril .................................................................. 234Spironolactone ....................................................... 235Spironolactone ....................................................... 235SR Poly Caspases Assay Kit .................................. 235SR Caspases 3 & 7 Assay Kit ................................ 235SR Caspase 9 Assay Kit ........................................ 235SR -101-Phe-CMK FLISP TM Assay Kit ............ 235SR -101-Leu-CMK FLISP TM Assay Kit ............ 235Stanozolol ............................................................... 235Staurosporine ........................................................ 235Stavudine ................................................................ 235Sterigmatocystin .................................................... 235Streptomycin sulfate ............................................. 236Streptozocin .......................................................... 236Stresscopin, human ............................................... 236Stresscopin-Related Peptide, human .................. 236Strontium Ranelate ................................................ 236

Substance P ............................................................. 236Substance P (1-4) ................................................... 236Substance P (1-7) ................................................... 236Substance P (1-9) ................................................... 236Substance P (7-11) ................................................. 236[Nle11] Substance P .............................................. 237[Pro9] Substance P ................................................ 237[Sar9] Substance P ................................................. 237[Tyr8] Substance P ................................................ 237Substance P, Free Acid .......................................... 237Suc-APA-pNA ........................................................ 237Suc-LEPF-pNA ...................................................... 237Sucralfate ................................................................ 237Suc-RGPF-pNA ..................................................... 237Sucrose Octasulfate-Aluminum Complex ......... 237Suc-SDPF-pNA ...................................................... 237Sulbactam ............................................................... 237Sulbactam sodium salt .......................................... 238Sulfadiazine ............................................................ 238Sulfadimethoxine ................................................... 238Sulfadoxine ............................................................. 238Sulfamethoxazole ................................................... 238Sulfasalazine ........................................................... 238Sulfluramid ............................................................. 238R, S-Sulforaphane ..............................................7, 238S-Sulforaphane ...................................................8, 239R-Sulforaphane .................................................8, 239S-Sulforaphene ...................................................8, 239Sulindac ............................................................18, 239Sulindac sulfide ...................................................... 239Sulindac sulfone ..................................................... 239Sumatriptan Succinate .......................................... 239Sunitinib Malate ..............................................29, 239Suramin hexasodium salt ..................................... 239SU-1498 .................................................................. 240Synephrine .............................................................. 240Syntide 2 ................................................................. 240Systemin .................................................................. 240

T ............................................................................... 240T2 Tetraol ............................................................... 240T2 Toxin .................................................................. 240T2 Triol ................................................................... 240Tacrolimus .............................................................. 240Tamibarotene ......................................................... 240Tamoxifen Citrate ............................................10, 241Tamsulosin Hydrochloride .................................. 241Tandutinib .............................................................. 241Tanshinones I ......................................................... 241Tanshinones IIA ..................................................... 241TAT .......................................................................... 241TAT 2-4 ................................................................... 241Taurine .................................................................... 241Taxanes.................................................................... 2422’-Acetyltaxol ......................................................... 2422’,7-bis Acetyltaxol ................................................. 24213-Acetyl-9-Dihydrobaccatin-III ........................ 2421-Hydroxy Baccatin I ............................................ 242


Baccatin III ............................................................. 242Benzyl Analog of Taxol ......................................... 242Cephalomannine ................................................... 2427-epi-Cephalomannine ......................................... 24210-Deacetylbaccatin-III ........................................ 24210-Deacetyl taxol ................................................... 2427-epi-10-Deacetyltaxol ......................................... 24310-Deacetyltaxol-B (10-Deacetylcephalomannine) .................. 24310-Deacetyltaxol-C ............................................... 24310-Deacetyl-7-xylosyltaxol, 90% ......................... 2432”,3”-Dihydrocephalomannine ............................ 2437-epi-Taxol ............................................................. 243Taxol-side chain acid ............................................. 243Taxol-side chain diol ............................................. 243Taxol-side chain methyl ester .............................. 243Taxol-side chain b-lactam .................................... 243Taxol C .................................................................... 2447-(triethylsilyl)-Baccatin III ................................. 2447-(triethylsilyl)-10-deacetyl Baccatin III ............ 244Xylosyltaxol, 90% ................................................... 244Xylosyltaxol C, 90% ............................................... 244Taxanes Standards Mixture .................................. 244Taxanine M ............................................................. 244Tazobactam ............................................................ 244Tazobactam sodium .............................................. 245TDZD-8 .................................................................. 245Tebuconazole....................................................16, 245Tegafur .................................................................... 245Teicoplanin ............................................................. 245Telbivudine ............................................................. 245Telmisartan ............................................................. 245Temocapril Hydrochloride .............................25, 245Temozolomide ....................................................... 245Tenatoprazole monosodium ................................ 246Teniposide .............................................................. 246Tenofovir Monohydrate ........................................ 246Tentoxin .................................................................. 246Tenoxicam .............................................................. 246Tenuazonic acid ..................................................... 246Terazosin Hydrochloride dihydrate .................... 246Terbinafine Hydrochloride ................................... 246Terbutaline ............................................................. 246Teriparatide Acetate .............................................. 247Terlipressin Acetate ............................................... 247Tetracycline ............................................................ 247Tetracycline hydrochloride .................................. 247D-Tetrahydropalmatine ........................................ 247L-Tetrahydropalmatine ......................................... 247D,L-Tetrahydropalmatine sulfate ........................ 247Tetrandrine ............................................................. 247Thalidomide ........................................................... 248Thapsigarin ............................................................. 248L-Theanine ............................................................. 248Theophylline ........................................................... 248Thiabendazole ........................................................ 248Thiamazole ............................................................. 248Thiamphenicol Glycinate HCl ............................. 248

Thiamphenicol Palmitate ..................................... 248Thiamphenicol ....................................................... 248S-(N-Thienylmethylthiocarbamoyl)- L-cysteine ...................................................... 249Thienylbutyl Isothiocyanate ................................. 249Thienyldecyl Isothiocyanate ................................ 249Thienyldodecyl Isothiocyanate ............................ 249Thienylethyl Isothiocyanate ................................. 249Thienylheptyl Isothiocyanate ............................... 249Thienylhexyl Isothiocyanate ................................ 249Thienylmethyl Isothiocyanate .............................. 249Thienylnonanyl Isothiocyanate ........................... 249Thienyloctyl Isothiocyanate ................................. 250Thienylpentyl Isothiocyanate ............................... 250Thienylpropyl Isothiocyanate .............................. 250Thioctic Acid ......................................................... 2501-Thio-b-D-glucose tetraacetate ......................... 2506-Thioguanine ........................................................ 250Thiolutin ................................................................. 250Thioridazine Hydrochloride ................................ 250Thiostrepton ........................................................... 2504-Thiouridine ......................................................... 251Thrombin Receptor Agonist ................................ 251Thymidine .............................................................. 251Thymopentin .......................................................... 251Thymopentin Acetate (TP-5) ............................... 251Thymosin a-1......................................................... 251Thymosin a-1 Acetate .......................................... 251Thymosin b-4 Acetate ........................................... 251Thymus Factor ....................................................... 252Thyrotropin-Releasing Hormone (TRH) ........... 252L-Thyroxine Sodium Salt Pentahydrate .............. 252TRH, Free Acid ...................................................... 252Tibolone .................................................................. 252Ticlopidine Hydrochloride ................................... 252Tigecycline ........................................................32, 252Timolol Maleate ..................................................... 252Tinidazole ............................................................... 252Tioconazole ......................................................16, 253Tioguanine ............................................................. 253Tirapazamine ......................................................... 253Tobramycin (free base) ......................................... 253Tobramycin Sulfate ................................................ 253Tolfenamic Acid ..................................................... 253Tolmetin Sodium ................................................... 253Toltrazuril ............................................................... 253Tolvaptan ................................................................ 253Tomoxetine Hydrochloride .................................. 254Topotecan Hydrochloride .................................... 254Toremifene.............................................................. 254Tosulfloxacin Tosylate ........................................... 254Total Cell Death Assay Kit.................................... 254Tozasertib ............................................................... 254Tramadol Hydrochloride ...................................... 254Trandolapril ......................................................25, 254Tranexamic acid ..................................................... 254Tranilast .................................................................. 255Tranylcypromine Hydrochloride ........................ 255


Tretinoin ................................................................. 255Triacetyl Resveratrol ............................................. 255Triacsin C ............................................................... 255Triadimefon ............................................................ 255Triadimenol ............................................................ 255Triamcinolone ........................................................ 255Triamcinolone acetonide ...................................... 256Triamcinolone Acetonide Acetate ....................... 256Trichostatin A ........................................................ 256Triflumizole ......................................................16, 256Triflumuron ............................................................ 256Trifluoperazine ....................................................... 256Trimebutine maleate ............................................. 256Trimebutine base ................................................... 256Trimetazidine ......................................................... 257Trimethoprim ........................................................ 257trans-3,4’,5-Trimethoxy-stilbene ......................... 257Triptolide ................................................................ 257Triptorelin Acetate ................................................. 257Triptorelin, [DTrp6]-LH-RH, Amide ................. 257Triticonazole.....................................................16, 257Troglitazone............................................................ 257Tropicamide ........................................................... 258Tropisetron Hydrochloride .................................. 258Tryprostatin A ........................................................ 258HT-2 Toxin ............................................................. 258Tubeimoside I ........................................................ 258Tuftsin ..................................................................... 258Tulobuterol ............................................................. 258Tunicamycin ........................................................... 258Tylosin tartrate ....................................................... 258Tylosin phosphate .................................................. 259[Asp371] Tyrosinase (369-377), human ............. 259Tyrphostin A25 ...................................................... 259Tyrphostin AG490 ................................................. 259Tyrphostin AG1295 ............................................... 259

U .............................................................................. 259Ubenimex ............................................................... 259Uniconazole ......................................................16, 259Universal TT epitope P2 (830-844) ..................... 259Uperolein ................................................................ 259Uracil ....................................................................... 260Urapidil ................................................................... 260Urapidil hydrochloride ......................................... 260Urocortin, human .................................................. 260Urocortin, rat ......................................................... 260Urocortin II, human .............................................. 260Urocortin II, mouse .............................................. 260Urocortin III, human ............................................ 260Urocortin III, mouse ............................................. 260Urodilatin CCC/ANP-95-126 .............................. 261Uroguanylin, human ............................................. 261Urotensin I.............................................................. 261Urotensin II (frog) ................................................. 261Urotensin Ii, human .............................................. 261Ursodeoxycholic acid ............................................ 261Usnic acid ............................................................... 261

V .............................................................................. 261Valaciclovir Hydrochloride .................................. 261Valdecoxib ........................................................17, 262Valganciclovir Hydrochloride .............................. 262Valinomycin ........................................................... 262Valproic Acid Sodium Salt .............................17, 262Valsartan ................................................................. 262Vancomycin Hydrochloride ...........................32, 262Vandetanib .................................................24, 29, 262Vanilloid Receptor Subtype 1 (VR1) ................... 262RC-160 (Vapreotide) ............................................. 263Vardenafil Dihydrochloirde ................................. 263Varenicline Tartrate ............................................... 263Vasoactive Intestinal peptide (VIP) .................... 263VIP, guinea pig ....................................................... 263[Lys8] Vasopressin ................................................. 263[Arg8] Vasotocin ................................................... 263Vatalanib Dihydrochloride ................................... 263Vecuronium Bromide ........................................... 263Veliparib ............................................................30, 264Venlafaxine Hydrochloride .................................. 264(±)Verapamil Hydrochloride ............................... 264Veratramine ............................................................ 264Verruculogen.......................................................... 264Vesicular Stomatitis Virus peptide ...................... 264Vidarabine .............................................................. 264Vildagliptin ............................................................. 264Vinblastine sulfate ................................................. 265Vincristine sulfate .................................................. 265Vindesine sulfate.................................................... 265Vindoline ................................................................ 265Vinleurosine sulfate ............................................... 265Vinorelbine base .................................................... 265Vinorelbine Ditartrate ........................................... 265Vitamin A ............................................................... 266Vitamin B6 ............................................................. 266Vitamin B12 ........................................................... 266Vitamin D2 ............................................................. 266Vitamin D3 ............................................................. 266Vitamin E, natural ................................................. 266Vitamin E ................................................................ 266Vitamin K3 ............................................................. 266Voglibose ................................................................ 266Voriconazole........................................................... 267Vorinostat .........................................................30, 267

W ............................................................................. 267Warfarin .................................................................. 267Warfarin Sodium ................................................... 267WHI-P131 .............................................................. 267Withaferin A .......................................................... 267W-K-Y-M-V-M-NH2............................................ 267Wogonin ...........................................................15, 267Wortmannin ........................................................... 268

X ............................................................................... 268Xenin ....................................................................... 268Xenopsin ................................................................. 268


p-Xyleneselenocyanate, 99% ..........................12, 268

Y ............................................................................... 268Yangonin ................................................................. 268

Z ............................................................................... 268Z-Ala-Ala-Leu-pNA ............................................. 268Zalcitabine .............................................................. 268Zanamivir ............................................................... 268Z-D-E-V-D-AMC.................................................. 268Z-F-R-AMC ............................................................ 269Z-Pro-D-Leu .......................................................... 269Zearalenone ............................................................ 269Zerumbone ............................................................. 269Zidovudine ............................................................. 269Zileuton................................................................... 269Ziprasidone ............................................................ 269Zoledronate Disodium.......................................... 269Zoledronic acid ................................................27, 269Zonisamide .......................................................20, 269


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Bertec Enterprises Co., Ltd. 6F No. 800 Jungjeng Road Junghe City, Taipei 235, Taiwan Tel: 886-2-2228-1324 Fax: 886-2-228-1111 Web: www.bertec.com.tw Email: [email protected]

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QWBio Room 505 Building 2 QingYuanXiLi, QingHe Haidian District, Beijing 100192, China Tel: 86-10-5987-0940 Fax: 86-10-5987-0942 Web: www.qwbio.com Email: [email protected]

Sapphire Bioscience Pty., Ltd. 126 Cope Street Waterloo, NSW 2017, Australia Tel: 61-2-9698-2022 Fax: 61-2-9698-1022 Web: www.sapphirebioscience.com Email: [email protected]

Sungwoo Life Science Co., Ltd. Samsung Bld. 4th Floor, 560-5 Uijeongbu 2Dong Uijeongbu-City Kyeonggi-Do, 480-849, South Korea Tel: 82-2-985-7471 Fax: 82-31-876-9149 Web: www.sungwools.com Email: [email protected]

Shigematsu & Co., Ltd. 2-5 Awaji-machi 2 chome, Chuo-ku Osaka 541-0047, Japan Tel: +81-6-6231-6146 Fax: +81-6-6231-6149 Web: www.shigematsu-bio.com Email: [email protected]

Antiangiogenic CompoundsAntimicrobialsApoptosis InducersBiologically Active PeptidesCancer Chemopreventive AgentsChemotherapeuticsDrug Discovery KitsNatural ProductsSignal Transduction Chemicals

LKT Laboratories, Inc.

Specialty Chem

icals For Life Science Research 2012-2014

LKT Laboratories, Inc.545 Phalen Blvd.St. Paul, MN 55130-5303

Tel: 651-644-8424Toll Free Tel: 888-558-5227Fax: 651-644-8357Toll Free Fax: 888-558-7329Web: www.lktlabs.com

Shenzhen Minn Bolin Bio-Tech Co., Ltd.A-22J, Xinhe-Aiqinju Building,No. 303, Shenhui RoadBuji, Longgang District,Shenzhen 518112, ChinaTel: 86-755-2510-6053Fax: 86-755-2510-6053Web: www.mbolin-lktlabs.com/cnEmail: [email protected]

International Distributors:(more distributors listed on the inside back cover)

Wako Pure Chemical Ind. Ltd.1-2, Doshomachi 3-ChomeChuo-Ku, Osaka 540-8964, JapanTel: +81-6-6203-3741Fax: +81-6-6201-5964Web: www.wako-chem.co.jpEmail: [email protected]

Biomol GmbHWaidmannstr. 3522769 Hamburg, GermanyTel: +49-40-85 32 600Fax: +49-40-85 32 60 22Web: www.biomol.deEmail: [email protected]

2012-2014 Catalog

LKT Laboratories, Inc. - Sapphire Bioscience

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