Outcomes of Liver Transplant for Biliary Atresia: A Ten Year Single Centre Experience Dr Yentl van Heerden; Dr Andrew Grieve, Professor Jerome Loveland For Paediatric Hepatobiliary and Liver Transplant Symposium University of the Witwatersrand 10-12 November 2017
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Liver Transplant for Biliary Atresia: A ten year single ... of Liver Transplant for... · •Complications: conflicting reports on the complication rates when comparing transplant
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Outcomes of Liver Transplant for Biliary Atresia: A Ten Year Single
Centre Experience Dr Yentl van Heerden; Dr Andrew Grieve, Professor Jerome Loveland
For Paediatric Hepatobiliary and Liver Transplant Symposium
University of the Witwatersrand
10-12 November 2017
Introduction
• Biliary Atresia is the most common indication for liver transplantation in the paediatric population1
• 60-80% of patients require liver transplant despite Kasai-portoenterostomy2,3
• Paradox: Earlier on in life (smaller patients, younger patients) with more severe grade of liver dysfunction
1.Esquivel C.O.; Iwatsuki S. et al. (1987) Indications for pediatric liver transplantation. Pediatrics. 111(6): 1039-1045
2.Laurent J, Gauthier F, Bernard O, Hadchouel M, Odivre M, Alagille D (1990) Gastroenterology 99: 1793±179
3.Lopez-Santamaria M, Gamez M, Murcia J, Diez-Pardo J,Diaz M, Leal N, et al. Long-term follow-up of patients with biliary atresia successfully treated with hepatic portoenterostomy.The importance of sequential treatment.Pediatr Surg Int
1998;13:327-330.
University of Witwatersrand – Wits Donald Gordon Medical Centre