Liver slides

Liver

Additional images from: http://www.bu.edu/histology/

and http://w3.ouhsc.edu/histology

Portal Triad (+lymph!)

Portal Triad (+ lymph!)

Portal Triad

Portal Triad (+lymph!)

Portal Triad (+lymph!)

Cords and Sinuses

Central Vein

The Lobules3 modes of architecture

• Classic Lobule – a hexagon with a central vein in the middle and portal triad (hepatic artery, portal vein, bile duct) at boundary points.

• Portal Lobule – connects 3 adjacent central veins into a triangle; it follows bile drainage

• Liver acinus – diamond shaped and bordered by 2 central veins and portal triads.

Classic Lobule

Classic Lobule

Portal Lobule

Liver acinus

Three Lobules

1)CLASSIC 2)PORTAL 3) LIVERACINUS

Shape: Polygon Triangle EllipseCentral Vein: Central 3 tips 2 tips

Lymph

• Endothelium of Sinusoids is fenestrated• Space of Disse = place of exchange of

materials between blood and hepatocyte

Space of Disse

Space of Disse

Bile

-Made by hepatocytes

-Drained into Bile ducts

-Moves in opposite direction from blood to portal triad

-Nasty stuff – Caniculi are bounded by tight junctions

Bile Canaliculus

Bile Canaliculus

Bile Canaliculus

Bile Canaliculus:

• holds bile

• btwn hepatocytes

• tight junctions

• communicates with bile duct

• flows in opposite direction of blood

Space of Disse:

• holds lymph

• communicates with sinusoids via fenstrations and with Space of Moll and lymphatics

Bile Canaliculus:

• holds bile

• btwn hepatocytes

• bounded by tight junctions

• communicates with bile duct

• flows in the opposite direction to blood

Space of Disse:

• holds lymph

• communicates with sinusoids via fenstrations and with Space of Moll and lymphatics

• flows in the direction of blood

What is at the pointer?

Is it carrying blood/bile to/from hepatocytes?

Portal Vein

What is at the pointer?

Is it carrying blood/bile to/from hepatocytes?

Bile duct

It is carrying bile from the hepatocytes?

Other elements

Kupffer Cell

Kupffer Cell

Practice

Practice your Liver - Silver

Practice your Liver - Silver

Liver EM

Liver EM