Alterations in skin blood flow at the fingertip of patients with
circulatory shock are related to disease severity and mortality
Mongkolpun et al.
Digital Supplementary Content
Figure S1. Thermostatic skin laser Doppler (SLD) probe
(Reference number 457, Perimed, Jarfalla, Sweden)
Figure S2. Lactate concentration (medians with 25th and 75th
percentiles) during the study period in survivors and non-survivors
(numbers of patients at each time point shown in brackets).
*p<0.05 vs survivors; ap<0.05 vs baseline in the same
group
Figure S3. Skin blood flow (medians with 25th and 75th
percentiles) at 37°C (SBF37) during the study period in survivors
and non-survivors. *p<0.05 vs survivors; ap<0.05 (vs 0 h in
the same group); bp<0.05 between the indicated times in the same
group; #p<0.05 vs healthy volunteers. APU: arbitrary perfusion
units
Figure S4. Finger temperature (medians with 25th and 75th
percentiles) during the study period in survivors and non-survivors
(numbers of patients at each time point shown in brackets).
*p<0.05 vs survivors
A
B
Figure S5A, S5B. Skin blood flow (SBF) and ∆SBF/∆T (medians with
25th and 75th percentiles) in patients with septic and with non
septic shock, ap<0.05 vs baseline in the same group; bp<0.05
between the indicated times in the same group
10
(A) (B)
(C) (D)
Figure S6A, S6B. Skin blood flow (SBF) and ∆SBF/∆T (medians with
25th and 75th percentiles) in septic shock survivors and
non-survivors; Figure S6C, S6D: SBF and ∆SBF/∆T in survivors and
non-survivors in non-septic shock, *p<0.05 vs survivors,
ap<0.05 vs baseline in the same group; bp<0.05 between the
indicated times in the same group
Figure S7. Peripheral perfusion index (PPI) (medians with 25th
and 75th percentiles) in survivors and non-survivors during the
study period. *p<0.05 vs survivors
Figure S8. Correlation between baseline cardiac index and skin
blood flow (SBF) in the 55 patients who had cardiac output
monitoring. APU: arbitrary perfusion units
Figure S9. The correlation between baseline norepinephrine dose
and SBF. APU: arbitrary perfusion units
Figure S10. Receiver operating characteristic (ROC) curves of
baseline parameters for prediction of mortality in patients with
septic shock. ScvO2: central venous oxygen saturation; CRT:
capillary refill time; SBF: skin blood flow; AUC: area under the
curve
Figure S11. Receiver operating characteristic (ROC) curves of
baseline parameters for prediction of mortality in patients with
non-septic shock. ScvO2: central venous oxygen saturation; CRT:
capillary refill time; SBF: skin blood flow; AUC: area under the
curve