Lipids • Hydrophobic vs. hydrophilic – For something to be soluble in water (and therefore hydrophilic) it must have a charge – Triglycerides don’t have any charges (hence the name neutral lipids) – Phospholipids have charge from the phosphate group so they have a hydrophilic end and a hydrophobic end Copyright 2005 Wadsworth Group, a division of Thomson Learning
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Lipids Hydrophobic vs. hydrophilic –For something to be soluble in water (and therefore hydrophilic) it must have a charge –Triglycerides don’t have any.
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Lipids• Hydrophobic vs. hydrophilic
– For something to be soluble in water (and therefore hydrophilic) it must have a charge
– Triglycerides don’t have any charges (hence the name neutral lipids)
– Phospholipids have charge from the phosphate group so they have a hydrophilic end and a hydrophobic end
Copyright 2005 Wadsworth Group, a division of Thomson LearningCopyright 2005 Wadsworth Group, a division of Thomson Learning
Phospholipids
Copyright 2005 Wadsworth Group, a division of Thomson LearningCopyright 2005 Wadsworth Group, a division of Thomson Learning
Phospholipids
Copyright 2005 Wadsworth Group, a division of Thomson LearningCopyright 2005 Wadsworth Group, a division of Thomson Learning
Hydrophilic (Charged) “Head”Including Glycerol part and charge from Phosphate and Nitrogen
Hydrophobic “Tails”
Phospholipids
Copyright 2005 Wadsworth Group, a division of Thomson LearningCopyright 2005 Wadsworth Group, a division of Thomson Learning
Phospholipids• Phospholipids in foods
– Lecithin – Found in eggs, liver,
soybean, wheat germ and peanuts
• Roles of phospholipids– Plasma membrane– Emulsifiers
Copyright 2005 Wadsworth Group, a division of Thomson LearningCopyright 2005 Wadsworth Group, a division of Thomson Learning
Copyright 2005 Wadsworth Group, a division of Thomson LearningCopyright 2005 Wadsworth Group, a division of Thomson Learning
Lipid Transport Animation
Lipid Transport• Lipoproteins and health
– LDL vs. HDL
Copyright 2005 Wadsworth Group, a division of Thomson LearningCopyright 2005 Wadsworth Group, a division of Thomson Learning
Why are fats absorbed through the lymphatic system?
• To answer this lets go back to the fat absorption process in the enterocytes– The fats are absorbed in either as fatty acids or
monoglycerides– Then they are remade into triglycerides– (But remember fats started off as triglycerides
to begin with)– So why remake triglycerides?
– High concentrations of free fatty acids near the inner side of the cell membrane can be toxic to the cells
– Sodium-free fatty acids and soaps are used to dissolve oils on your skin
– Imagine what that would do cell membranes!– So inside the enterocytes the fatty acids are ferried
around by fatty acid binding proteins combined to form triglycerides which then coalesce together with cholesterol and proteins and form chylomicrons
• Chylomicrons belong to a group of compounds referred to as lipoproteins.
They all contain a core of lipids and a shell of protein, cholesterol and phospholipids. This outer shell acts as an emulsifier, allowing the lipid it is carrying to be transported in a water-based fluid such as blood or lymph
• The proteins associated with the chylomicrons direct the uptake and breakdown of the chylomicrons in tissues
• Chylomicrons are very large particles (Remember they can be visualized by electron microscopy)
• They average between 100-500 nm in diameter
• Because of their size they are excluded from entering the blood
• The lymph capillary cells also cannot allow chylomicrons is but..
• Lymphatic capillaries function in a slightly different way to bring lymph in.
Chylomicrons are big and reflect enough light that after a fatty meal you can see them in plasma (blood without the red blood cells). The tube on the left is without chylomicrons and the one on the right has chylomicrons in it. The pinkish material is a collection of chylomicrons.