the live session will start at 18:15 hours C.E.T. Welcome! you are part of a growing community of people interested in our educational programmes online. As of the 11 th of July 2013 this is the 285 th e-session that is offered to 5,xxx registered users who have viewed 24,xxx e-sessions since January 2008 Please note that this activity is CME accredited . At the end of the presentation, by closing the webcast window, you will be directed to the CME evaluation and multiple-choice test.
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Lifestyle modification and prevention of breast cancer
I made this e-grandroud presentation at the European School of Oncology on Thursday 11 July 2013. The recorded session is available on their web site. Thanks for watching.
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Transcript
the live session will start at 18:15 hours C.E.T.
Welcome!you are part of a growing community of people interested in our
educational programmes online.
As of the 11th of July 2013 this is the 285th e-session that is offered to 5,xxx registered users who have viewed 24,xxx e-sessions
since January 2008
Please note that this activity is CME accredited.
At the end of the presentation, by closing the webcast window, you will be directed to the CME evaluation and multiple-choice test.
Expert: Dr. Abdul Basit,
University Hospital of North Staffordshire, Stoke-on-Trent, United Kingdom
Discussant: Dr. Fatima Cardoso,
Champalimaud Cancer Center, Lisbon, Portugal
e-grandround
Lifestyle modification and prevention of breast cancer
Lifestyle modification and prevention of breast cancer
Abdul BasitUniversity Hospital of North Staffordshire
Stoke-on-Trent
United Kingdom
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How Does Breast Cancer Develop ?
A multistep process taking many years in most cases
Cell Proliferation
Oestrogen Hormone breast cell division
Cancer causing agents bind more strongly to maturing cells of girls and young women.
From the Cornell University Program on Breast Cancerand Environmental Risk Factors in New York State 1997
How Does Breast Cancer Develop ?
Puberty – First pregnancy
After first full term pregnancy, breast cells are mature and are less sensitive to DNA
damage.
Breast feeding further reduces the
breast cells’ sensitivity to mutations
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Dysplasia: Cells proliferate too much and look abnormal in
shape and orientation.
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How does the breast cancer develop ?Prof. Michael Baum University College , London
ERAromatase 8
OtherMesothelioma
Cervix Liver
Multiple myeloma Brain with CNS
Oral Ovary
Leukaemias Uterus
Pancreas Stomach
Oesophagus Kidney
Bladder
Malignant melanoma
N-H-LProstate
Colorectal Lung
Breast
0 10,000 20,000 30,000 40,000 50,000
Male Female
Number of new cases
Figure 1.1: The 20 most commonly diagnosed cancers (excluding non-melanoma skin cancer), UK, 2007
The largest group of survivors are those of breast cancer9
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Your views are important!Remember that you can ask questions and send comments at
any time.
Breast cancer is not the number one killerCause of Death in Females 2009
0
5000
10000
15000
20000
25000
30000
35000
IHD
CVA
Denen
tia
Influ
enza
Lung C
ance
r
Chronic
lower
Res
piratry
Breas
t Can
cer
Nu
mb
er
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15% decrease (42-27/100,000)
Life time risk of 1:8
47,700 new cancers per annum (2008) < 50yrs 20% 50-70yrs 50% only 33% are Screen
University Hospital of North Staffordshire 2008-0913
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12 Things you must know before you can plan treatment for breast cancer
Age at DiagnosisTumour Size
(1)Tumour Grade (2) Tumour Type
Lymph Node Status (3)
Lympho-vascular Invasion
(Nottingham Prognostic Index)
Margins of clearanceImmunohistochemistry -3 (IHC-3) ER PgR Her2
Menopausal status Health performance status
Presentation source Screening / Symptomatic
1,2,3 = Nottingham Prognostic Index (NPI)
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Life events associated with breast cancer
AgeSex – Female
RaceAge at Menarche
Age at first live birthMultiparity – Nulliparity
Breast Feeding
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Life events associated with breast cancer (Cont)
Contraceptive Pill
Diet – Exposure to Oestrogens
Alcohol
Lack of exercise
Age at Menopause
Hormone Replacement Therapy
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Ductal Cancer (Ductal Carcinoma of
no special Type)
Lobular Cancer
80 %
10 %
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Breast cancer risk factors that are difficult to modify
Age
Race
Age at menarche
Age at menopause
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Your views are important!Remember that you can ask questions and send comments at
any time.
Recommended lifestyle modifications
Diet
Having first child under 30
Alcohol
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Before After
Reduce intake of Animal sourced fat
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Thousands of women die from breast cancer caused by drinking: researchThe risk of developing breast cancer from drinking even small amounts of alcohol is being ignored by women with thousands now needlessly dying every year.
Thousands of women die from breast cancer caused by drinking: research
Telegraph.co.uk
The risk of developing breast cancer from drinking even small amounts of alcohol is being ignored by women with thousands now needlessly dying every year.