Research Regenerative Medicine • Biomechanics (Billiar, Gaudette, Lee, Pins, Rolle, Troy, Wen) • Stem cell biology and engineering (Dominko, Gaudette, Jain, Page) • Tissue engineering (Billiar, Dominko, Gaudette, Jain, Peterson, Pins, Rolle, Wen) • Biomaterials (Billiar, Camesano, Gaudette, Jain, Peterson, Pins, Rolle) • Mechanobiology (Billiar, Wen, Lee) Medical Diagnostics • Biomedical instrumentation (Mendelson) • Telediagnostics (Mendelson) • Biosensors (Camesano, Iannacchione, Jain, Lambert, Mendelson, Zhou) • Signal processing (Flaherty, Mendelson) • Neutron tomography (Medich) • Mobile health (Mendelson) Bioinformatics and Computational Biology • Biostatistics, statistical genetics and genomics (Flaherty, Wu) • Biological and biomedical data mining (Albrecht, Flaherty, Lee, Ruiz) • Simulation of biological systems (Ryder, Troy) • Pharmacokinetic and pharmacodynamic modeling (Kaminski) • Computational cell biology (Lee) Bioreactors, Bioprocessing, Bioseparations • Bioreactors – tissue and plant (Billiar, Gaudette, Lambert, Rolle, Weathers) • Pichia, S. cerevisiae, E. coli expression systems (BioProcess Center, Rao) • Fermentation development and optimization (BioProcess Center, Rao) • Biofuels/bioenergy (Clark, Deskins, Rao, Timko, ompson, Weathers) Therapeutics Screening and Development • Delivery, nanomedicine, screening, testing (Camesano, Dittami, Duffy, Gericke, Jain, Kaminski, Rao, Stroe, Weathers, Zhou) • High throughput microfluidics (Albrecht, Srinivasan, Zhou) • Cancer Cell Biology (Dominko, Duffy, Gericke, Lee, Jain, Manning) Surface Science and Materials Chemistry • Surface functionalization and characterization (Grimm, Lambert, McDonald) Neuroscience and Neuroengineering • Degenerative disease/regenerative processes (Adams, Albrecht, Duffy, Jain, Lambert, Pins, Stroe) • Neuronal imaging and optogenetics (Albrecht, Srinivasan) • Neuronal cell biology (Albrecht, Lee, Srinivasan) • Developmental neuronal biology (Ryder) • Biomaterials for neuron applications (Jain, Zhou) • Behavioral biology (Albrecht, Duffy, Gegear, Matthews) • Traumatic brain injury and stroke (Jain) Biomedical Imaging and Spectroscopy • Fluorescence spectroscopy and lifetime methods (Connors, Gericke, Lambert) • Spectroscopic imaging (Lambert) • Time-resolved imaging (Lambert) • IR chemical imaging (Gericke) • Deconvolution imaging (Albrecht, Duffy, Manning, Vidali) • Atomic force microscopy (Camesano, Wen) • Total internal reflection/single molecule fluorescence microscopy (Gericke) • Confocal (Tuzel, Vidali, Lee, Manning) • MRI for diagnostics of traumatic brain injury (Jain) • Quantitative CT image analysis (Troy) • Quantitative live cell imaging (Lee, Manning, Vidali) Membrane and Matrix Biology • Extracellular matrix/cell wall biology (Billiar, Camesano, Duffy, Gericke, Politz, Rao, Rolle, Wen) • Lipid biochemistry, self-assembly (Duffy, Gericke, Iannacchione, MacDonald) • Membrane proteins (Arguello, Dempski, Dominko, Duffy, Gericke, Iannacchione, Jain, Kaminski, Page, Ryder, Stroe, Tuzel) • Protein structure/function and polymerization (Arguello, Dempski, Gericke, Kaminski, Iannacchione, Stroe, Vidali) Medicinal and Bioorganic Chemistry • Novel synthetic strategies for drug development (Burdette, Dittami, Emmert) • Synthesis of fluorescent/chromophoric molecules (Burdette) • Novel biomaterial synthesis (Burdette, MacDonald) Microbiology • Fungal pathogens (Rao) • Tuberculosis (Arguello, Shell) • Prokaryotic molecular genetics (Shell) WPI approaches life sciences research in a collaborative way, driven by a desire to solve important problems that often cross departmental boundaries. The Life Sciences and Bioengineering Center houses representatives from six academic departments and over 50 faculty members. LIFE SCIENCES & BIOENGINEERING