Safety The ImSAIDs® are comprised of natural amino acids that have demonstrated no toxicity or immune suppression in numerous animal studies, including dogs, cats, and a variety of other species ImSAIDs® - Cellular Modulation in vivo and in vitro results have shown the ImSAIDs® to help support the following: reduce granulocyte acvaon and chemotaxis diminish oxidave burst capacity and the producon of reacve oxygen species aenuate the effects of endotoxin, and reduce allergic & anaphylacc reacons (type I hypersensivity and IgE-mediated reacons) Additional References on ImSAIDs® Immunopharmacology Mathison R, et al. Modulaon of neutrophil funcon by the tripepde feG. BMC Immunol. 2003 Mar 4;4:3. 2003 Mathison R, et al. Regulaon of leukocyte adhesion to heart by the tripepdes feG and feG(NH2). Can J Physiol Pharmacol . 2001 Sep; 79(9):785-92. Mathison RD and Davison JS. The Tripepde feG Regulates the Producon of Intracellular Reacve Oxygen Species by Neutrophils. J Inflamm (Lond). 2006 Jun 15;3(1):9 Mathison R, Davison JS, Befus AD. Neuroendocrine regulaon of inflammaon and ssue repair by submandibular gland factors. Immunol Today.1994 Nov;15(11):527-32. Mathison RD, et al. The tripepde feG inhibits leukocyte adhesion. J Inflamm (Lond). 2008 May 20;5:6. Mathison R, Davison JS. Molecular characteriscs of the tripepde feG accounng for different biological acvies. Proc West Pharmacol Soc . 2007;50:101-4. Mathison RD, et al.. A pepde from the submandibular glands modulates inflammatory responses. Int Arch Allergy Immunol . 1997 May-Jul;113(1-3):337-8. Mathison RD, et al. Submandibular glands: novel structures parcipang in thermoregulatory responses. Can J Physiol Pharmacol. 1997 May; 75(5):407-13. leukoSTAT™ ( ImSAIDs® Enabled) leukoSTAT™ contains the ImSAIDs®; patented amino acid complexes that maintain systemic health, by aiding in the reducon of leukocyte acvaon and chemotaxis. ImSAIDs® are Not COX/LOX inhibitors or steroids, but naturally occuring amino acid complexes that nature designed to posively influence the immune system, including leukocytes. leukoSTAT™ Product & Ordering IMULAN has developed a highly palatable, chewable tablet for dogs and cats. The small, 625mg chewable tablet can be used when only small amounts of material can be given orally. leukoSTAT™ is available in 30 and 120 count boles. To purchase LeukoSTAT™; please go to www.IMULAN.com and set up an account. You may also contact IMULAN at info@ imulan.com IMULAN BioTherapeucs 4221 Mitchell Avenue St. Joseph, MO 64507 www.IMULAN.com 480-248-2176 . Immuno-Nutrional Technology ALL Inflammation is Regulated by Leukocytes