Left Ventricular Non-Compaction Associated With Patent Ductus Arteriosus Shih-Hung Hsiao, 1 Tao Yu Lee, 1 Guang-Yuan Mar, 1 Nan-Jing Peng, 2 Jyh-Seng Wang, 3 Ming-Ting Wu, 4 Kai-Sheng Hsieh, 5 Chun-Peng Liu 1 and Hung-Tin Chiang 1 Isolated left ventricular non-compaction (LVNC) is a rare congenital anomaly. It is characterized by numerous prominent ventricular trabecullations and deep intertrabecular recesses. The incidences of associated cardiovascular complication and congenital heart disease are high. It is associated with congestive heart failure, ventricular arrhythmia, embolic events, and distinctive facial dysmorphism. Familial tendency has also been reported. It is believed to represent an arrest in endomyocardial morphogenesis. The prognosis for patients is grim. The most common cause of death in these patients was sudden cardiac collapse. Many patients suffered from transient ischemic attacks, pulmonary embolisms, heart failure events, pulmonary edema episodes, cardiogenic shock and sustained ventricular tachycardia. Even asymptomatic patients were still at risk of unpredictable ventricular arrhythmia and sudden cardiac collapse. We report a 36-year-old female with patent ductus arteriosus (PDA) and an incidental finding of left ventricular non-compaction. As far as we know, this is the first report of left ventricular non-compaction associated with PDA. Key Word: Left ventricular non-compaction INTRODUCTION Isolated left ventricular non-compaction (LVNC) is a rare congenital anomaly. It is characterized by numer- ous prominent ventricular trabecullations and deep intertrabecular recesses. The incidence of cardiovascular complication is high. It is associated with congestive heart failure, ven- tricular arrhythmia, embolic events, and distinctive facial dysmorphism. Familial tendency has also been reported. It is believed to represent an arrest in endomyocardial morphogenesis. Previous investigators have viewed it as either persisting sinusoids or spongy myocardium. A study of 8 children published by Chin et al. 1 demonstrated the presence of a continuous layer of endothelium from the ventricular cavity into the recesses without coronary communication to the ventricular cav- ity. LVNC has also been associated with various con- genital heart diseases. The prognosis for patients is grim: according to a Mayo clinic report, 2 59% of patients with isolated ventricular noncompaction had died or had a heart transplant within 6 years of diagnosis. The most common cause of death in these patients was sudden car- diac collapse. Many patients suffered from transient ischemic attacks, pulmonary embolisms, heart failure events, pulmonary edema episodes, cardiogenic shock and sustained ventricular tachycardia. Even asymptom- atic patients were still at risk of unpredictable ventricular arrhythmia and sudden cardiac collapse. 3-9 We report a 36-year-old female with patent ductus arteriosus (PDA) and an incidental finding of left ven- 251 Acta Cardiol Sin 2004;20:251-5 Case Report Acta Cardiol Sin 2004;20:251-5 Received: April 7, 2004 Accepted: June 4, 2004 1 Division of Cardiology, 2 Division of Nuclear Medicine, 3 Division of Pathology, 4 Division of Radiology, and 5 Department of Pediatrics, Kaohsiung Veterans General Hospital, and National Yang-Ming University, School of Medicine, Taipei, Taiwan. Address correspondence and reprint requests to: Dr. Tao Yu Lee, Division of Cardiology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386, Da-Chung 1 st Road, Kaohsiung 813, Taiwan. Tel: 886-7-342-2121 ext. 2012; Fax: 886-7-346-4475; E-mail: [email protected]
5
Embed
Left Ventricular Non-Compaction Associated With … · Left Ventricular Non-Compaction Associated With Patent Ductus ... ECG showed basically nor-mal sinus rhythm with rare ventricular
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.