Lecture 4: FMOs (continued) & Arrow Pushing (the beginning) Announcements: Problem Set 1 comments: • Average: 67% (too low for a review of undergrad organic!) ◦ Please review your problem set and learn/remember any concepts you are missing ◦ Answer Key posted online ◦ Problem Set 2 due now • NSF GRFP panel tomorrow, 1pm, Smith 140 • Today's Organic Journal Club: Dr. Shane Plunkett (postdoc in my lab): PhD summary • Monday: Biochem Colloquium, 4pm, 101 BRL • Prof. Brian McNaughton, Colorado State "Strategies & Tactics for Biologics Dicovery" Today: FMOs, continued from last time • Heteroatoms ◦ Substituent effects ◦ 12-Step Program for Arrow Pushers • 3 Universal Effects that Govern Reactivity & Structure • Arrow-pushing topic: Polar Reactions under Basic Conditions • Alkyl Electrophiles: Substitution & Elimination ◦ Addition to Electrophilic π-Bonds: Carbonyls & Conjugate Additions ◦ Hard-Soft Acid-Base Theory (HSAB) ‣ Substitution at sp2 carbons: Carbonyls & Aryl ◦