ANTIBIOTIKA ANTIBIOTIKA Dr.I.B.NGURAH,M.For Dr.I.B.NGURAH,M.For BAGIAN FARMAKOLOGI FK BAGIAN FARMAKOLOGI FK UNUD UNUD
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8/18/2019 Lecture 11 Antibiotika pspdg unud
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ANTIBIOTIKAANTIBIOTIKA
Dr.I.B.NGURAH,M.ForDr.I.B.NGURAH,M.For
BAGIAN FARMAKOLOGI FKBAGIAN FARMAKOLOGI FKUNUDUNUD
8/18/2019 Lecture 11 Antibiotika pspdg unud
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PendahuluanPendahuluan
Fleming, peniillin, !"#$Fleming, peniillin, !"#$
!"%#!"%#
An&i'io&i(a 'er(em'ang pe)a&An&i'io&i(a 'er(em'ang pe)a&
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Ba(&erio)&a&i(Ba(&erio)&a&i(
Ba(&eri)idBa(&eri)id
Kadar ham'a& minimalKadar ham'a& minimal Po)& an&i'io&i e*e&Po)& an&i'io&i e*e&
+pe(&rum lua) on&oh- e&ra/lin0+pe(&rum lua) on&oh- e&ra/lin0
+pe(&rum )empi& on&oh+pe(&rum )empi& on&oher/&hrom/in0er/&hrom/in0
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ANTIBIOTIKAANTIBIOTIKA
PENICILLINPENICILLIN
B1N23L P1NI4ILLINB1N23L P1NI4ILLIN
B1N2AHIN1 P1NI4ILLIN GB1N2AHIN1 P1NI4ILLIN G
P1NI4ILLIN 5P1NI4ILLIN 5AMPI4ILLIN, AMO6I4ILLINAMPI4ILLIN, AMO6I4ILLIN
P1NI4ILLIN UNUK P+1UDOMONA+P1NI4ILLIN UNUK P+1UDOMONA+
KL1B+I1LA KL1B+I1LA PRO1U+PRO1U+
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4ARB1NI4ILLIN4ARB1NI4ILLIN
I4AR4ILLIN I4AR4ILLIN
P1NI4ILLIN AHAN P1NI+ILINA+1P1NI4ILLIN AHAN P1NI+ILINA+1
O6A4ILLINO6A4ILLIN
DI4LO6A4ILLINDI4LO6A4ILLIN
NAF4ILLINNAF4ILLIN
M1HI4ILLINM1HI4ILLIN
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MEKANISME KERJAMEKANISME KERJA
SPEKTRUMSPEKTRUM
RESISTENSIRESISTENSIESOESO
INDIKASI KLINIS,KONTRA INDIKASIINDIKASI KLINIS,KONTRA INDIKASI
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SULFONAMIDESULFONAMIDE
M1KANI+M1 K1R7AM1KANI+M1 K1R7A PABAPABA
+ULFONAMID1+ULFONAMID1
DIHIDROFOLADIHIDROFOLA
RIM1HOPRIM RIM1HOPRIM
1RAHIDROFOLA 1RAHIDROFOLA
+IN1+A RNA DAN DNA+IN1+A RNA DAN DNA
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MACAM-MACAM SULFONAMIDEMACAM-MACAM SULFONAMIDE
(LIHAT DIKTAT)(LIHAT DIKTAT)
FARMAKOKIN1IK FARMAKOKIN1IK
K1RN8I41RU+K1RN8I41RU+
1+O1+O INDIKA+I KLINI+INDIKA+I KLINI+
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CHLORAMPHENICOLCHLORAMPHENICOL
D1RI5AN3A HIAMPH1NI4OLD1RI5AN3A HIAMPH1NI4OL P1RB1DAAN D1NGAN 4HLORAMPH1NI4OLP1RB1DAAN D1NGAN 4HLORAMPH1NI4OL
FARMAKOKIN1IK FARMAKOKIN1IK
M1KANI+M1 K1R7AM1KANI+M1 K1R7A
+P1KRUM+P1KRUM
R1+I+1N+IR1+I+1N+I
1+O1+O
INDIKA+I KILINIK INDIKA+I KILINIK
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MACROLIDEMACROLIDE
ERYTHROMYCINERYTHROMYCIN
SPIRAMYCINSPIRAMYCIN
CHLARITHROMYCINCHLARITHROMYCIN AZITHROMYCINAZITHROMYCIN
ROXITHROMYCINROXITHROMYCIN
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FARMAKOKINETIKFARMAKOKINETIK
MEKANISME KERJAMEKANISME KERJA
SPEKTRUMSPEKTRUM RESISTENSIRESISTENSI
ESOESO
INDIKASI KLINIS, KONTRA INDIKASIINDIKASI KLINIS, KONTRA INDIKASI
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BEDA ERYTHROMYCINBEDA ERYTHROMYCIN
SPIRAMYCINSPIRAMYCIN
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TETRACYCLINTETRACYCLIN
FARMAKOKINETIK FARMAKOKINETIK MEKANISME KERJAMEKANISME KERJA SPEKTRUMSPEKTRUM
RESISTENSIRESISTENSI ESOESO INDIKASI KLINIK, KONTRA INDIKASIINDIKASI KLINIK, KONTRA INDIKASI
BEDA DENGAN DOXYCYCLIN,BEDA DENGAN DOXYCYCLIN,MINOCYCLINMINOCYCLIN
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Penggunaan an&i'io&i(a pada (ehamilanPenggunaan an&i'io&i(a pada (ehamilan
Peniillin, er/&hrom/in, ephalo)porinPeniillin, er/&hrom/in, ephalo)porin
Aminogl/o)ideAminogl/o)ide
+ul9onamide+ul9onamide
4hlorampheniol4hlorampheniol
:uinolone:uinolone
e&ra/lin e&ra/lin
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