Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH
Layer-Specific Attentional Modulation in Early Visual Areas Elizabeth A. Buffalo Laboratory of Neuropsychology National Institute of Mental Health, NIH.
Dec 13, 2015
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Layer-Specific Attentional Modulation in Early Visual Areas
Elizabeth A. BuffaloLaboratory of Neuropsychology
National Institute of Mental Health, NIH
Fries, Reynolds, Rorie, and Desimone (Science, 2001)
Attentional Modulation in Area V4
Unattended stimulus
Attended stimulus
V4
v2 v2
pp
V1V4
TETEO
V2
1°
RF
1°
RF
1°
RF
1°
RF
Resp
on
se/
Rew
ard
0.5-5.0s1.0s
Spatial Attention Task
fix
Electrode Path
Modified from Gegenfurtner, Kiper, and Levitt (1997)
Superficial Recording Deep Recording
Electrode Path
Modified from Gegenfurtner, Kiper, and Levitt (1997)
Attentional Modulation in Area V2Superficial Layers
Attentional Modulation in Area V2Deep Layers
Superficial Layers
Deep Layers
Area V1 Area V2
Superficial Layers Deep Layers
Cortical Circuitry
Feedforward intracortical connections V1 (II/III) to V2 (IV)
Cortical Circuitry
Feedforward intracortical connections V1 (II/III) to V2 (IV)
Feedback intracortical and subcortical connectionsV2 (VI) to V1 (VI)V1 (V) to SC,V1 (VI) to LGN,V2 (V) to SC, Pons, Striatum
Cortical Circuitry
V1
TE
V2
V4
TEO
pfc
Superficial LayersGamma-frequency synchronization:
Attention
Superior Colliculus, Striatum, Pons, LGN
V1
TE
V2
TEO
pfc
V1
TE
V2
V4
TEO
pfc
Superficial LayersGamma-frequency synchronization:
Attention
Deep LayersBeta-frequency synchronization:
???
Baker, Kilner, Pinches, and Lemon (1999)
Beta-frequency Oscillations
Synchronization correlated with behavioral response
Superficial Layers Deep Layers
Synchronization correlated with behavioral response
Superficial Layers Deep Layers
Superior Colliculus, Striatum, Pons, LGN
V1
TE
V2
TEO
pfc
V1
TE
V2
V4
TEO
pfc
Superficial LayersGamma-frequency synchronization:
Attention
Deep LayersBeta-frequency synchronization:
Motor response inhibition?
Superficial Layers: Coherence Across Time
Deep Layers: Coherence Across Time
Cortical Circuitry
LGN
Higher Cortical Areas
SC
Cortical Circuitry
LGN
Higher Cortical Areas
SC
Inhibitory Interneurons
Collaborators
Robert DesimonePascal FriesTim BuschmanDavid HeisterPartha Mitra
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