LAXMI ORGANIC INDUSTRIES3.imimg.com/data3/EM/DW/MY-4381467/ethyl-chloroaceto... · 2020. 6. 4. · Nariman Point, Mumbai 400 021 Tel No. : +91 22 49104444 Fax No. : +91 22 22853752

Safety Data SheetAccording to 1907/2006/EC, Article 31

01 Identification of the substance/mixture and of the company/undertaking

LAXMI ORGANIC INDUSTRIES

Revision: 11.09.2014

Product details: Trade name: ethyl 4-chloroacetoacetate Pre-registration number: 17-2119897496-15-0000

Relevant identified uses of the substance or mixture and uses advised

against

Application of the substance / the preparation

Used as medicine and pesticide intermediates

02 Hazards Identification

Classification of the substance or mixture

Classification according to Regulation (EC) No 1272/2008 Classification according to Directive 67/548/EEC

or Directive 1999/45/EC

Acute Tox. 3 H301 Toxic if swallowed

GHS05 corrosion

Skin Corr. 1B H314 Causes severe skin burns and eye damage

GHS06 skull and crossbones

T: Toxic

R25: Toxic if swallowed

C: Corrosive

R35: Causes severe burns

Information concerning particular hazards for human

and environment: Not applicable

Manufacturer / Supplier

Laxmi Organic Industries Ltd.

Chandermukhi, 3rd Floor,

Nariman Point, Mumbai 400 021

Tel No. : +91 22 49104444

Fax No. : +91 22 22853752

Email :

Contact details of European importer

Laxmi Organic Industries (Europe) B.V. Burgemeester Feithplein 11, 2273 BZ Voorburg, The Netherlands

Tel No. : +31(0)70 20 40 600

Fax No. : +31 (0)70 20 40 604

Email :

Emergency telephone numbers:

+31 646159978 (for EU)

+91 7738092735 (for other regions)

Other Comments (e.g. language(s) of the phone service): English

[email protected]

[email protected]

Label elementsThe substance is classified and labelled according to the CLP regulation

Labelling according to Regulation (EC) No 1272/2008

Hazard pictograms:

GHS05 GHS06

SIGNAL WORD Danger

Hazard statements

H301 Toxic if swallowed.

H314 Causes severe skin burns and eye damage.

Precautionary statements

P301+P310 IF SWALLOWED: Immediately call a POISON

CENTER or doctor/physician

P303+P361+ IF ON SKIN (or hair): Remove/Take off immediately

P353 all contaminated clothing. Rinse skin with

water/shower.

P305+P351+ IF IN EYES: Rinse cautiously with water for several

P338 minutes. Remove contact lenses, if present and easy

to do. Continue rinsing

P310 Immediately call a POISON CENTER or doctor/

physician

P405 Store locked up.

P501 Dispose of contents/container in accordance with

local/regional/national/international regulations

Other Hazards:

Results of PBT and vPvB assessment

PBT : Not applicable

vPvB : Not applicable

03 Composition/Information on Ingredients

Chemical characterization: Substances

CAS No.: Description: ethyl 4-chloroacetoacetate

Identification number(s) Additional information:

EC number : 211-317-0 Molecular Formula : C6H9ClO3

Molecular Weight : 164.59

638-07-3

04 First Aid Measures 05 Firefighting Measures 06 Accidental Release Measures

General information:

Immediately remove any clothing soiled

by the product.

In case of irregular breathing or

respiratory arrest provide artificial

respiration.

After inhalation:

Supply fresh air. If required, provide

artificial respiration. Keep patient warm.

Consult doctor if symptoms persist.

In case of unconsciousness place patient

stably in side position for transportation.

After skin contact: Immediately wash

with water and soap and rinse thoroughly.

After eye contact: Rinse opened eye for

several minutes under running water.

Then consult a doctor.

After swallowing:

Do not induce vomiting; call for medical

help immediately.

Drink plenty of water and provide fresh

air. Call for a doctor immediately.

Information for doctor: Treat

symptomatically and supportively.

Most important symptoms and effects,

both acute and delayed:

No further relevant information available.

Indication of any immediate medical

attention and special treatment

needed:

No further relevant information available.

Extinguishing media

Suitable extinguishing agents:

CO2, powder or water spray. Fight

larger fires with water spray or alcohol

resistant foam.

Special hazards arising from the

substance or mixture:

May produce carbon mono-oxide and

carbon dioxide.

Advice for firefighters

Protective equipment: Wear self

contained breathing apparatus for fire

fighting if necessary.

Personal precautions, protective

equipment and emergency

procedures:

Wear protective equipment. Keep

unprotected persons away.

Environmental precautions: Do not

allow to enter sewers/ surface or ground

water.

Methods and material for containment

and cleaning up:

Use neutralizing agent.

Keep in suitable, closed containers for

disposal.

Dispose contaminated material as waste

according to item 13.

Reference to other sections:

See Section 7 for information on safe

handling.

See Section 8 for information on personal

protection equipment.

07 Handling and Storage

Handling

Precautions for safe handling

Ensure good ventilation/exhaustion at the workplace.

Information about fire - and explosion protection:

Keep ignition sources away - Do not smoke.

Conditions for safe storage, including any incompatibilities

Storage

Requirements to be met by storerooms and receptacles:

Store in a cool, dry, well-ventilated area away from incompatible substances.

Information about storage in one common storage facility:

Store away from strong acids, alkali or oxidizing agents.

Store away from reducing agents.

Further information about storage conditions:

Keep container tightly sealed.

Specific end use(s)

Used as medicine and pesticide intermediates.

08 Exposure Controls/ Personal Protection

Additional information about design of technical facilities:

Local exhaust ventilation required plus good work practise.

Safety shower. Eye fountain.

Control parameters

Ingredients with limit values that require monitoring at the workplace: Not required.

Exposure controls

Personal protective equipment:

General protective and hygienic measures:

Keep away from foodstuffs, beverages and feed.

Immediately remove all soiled and contaminated clothing

Wash hands before breaks and at the end of work.

Avoid contact with the eyes and skin.

Respiratory protection:

In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure

use self-contained respiratory protective device.

Protection of hands Eye Protection

The glove material has to be impermeable and resistant to

the product/ the substance/ the preparation. Selection of

the glove material on consideration of the penetration

times, rates of diffusion and the degradation.

Material of gloves

Butyl rubber, BR Nitrile rubber, NBR

The selection of the suitable gloves does not only depend

on the material, but also on further marks of quality and

varies from manufacturer to manufacturer.

Penetration time of glove material

Full Contact:

Glove material: Butyl rubber

Glove thickness: 0.7 mm

Breakthrough time: > 480 min

Splash Contact:

Glove material: Nitrile rubber

Glove thickness: 0.40 mm

Breakthrough time: > 30 min

Body protection:

Protective work clothing

Tightly sealed gogglesProtective gloves

09 Physical and Chemical Properties

Information on basic physical and chemical properties

General Information

Appearance:

Colour: Yellow

Odour: Characteristic

pH-value (10 g/l) at 20°C: 2.9

Change in condition

Melting point/Melting range: -8°C

Boiling point/Boiling range: 220°C (1.013 hPa)

Flash point: 106°C

Flammability (solid, gaseous): Not applicable.

Ignition temperature: 320°C

Danger of explosion: Product does not present an explosion hazard

Explosion limits:

Lower: 1.8 Vol %

Upper: Not determined.

Vapour pressure at 20°C: 0.1 hPa

Density at 20°C: 1.21 g/cm³

Solubility in / Miscibility with 47 g/l

water at 20°C:

Segregation coefficient (n-octanol/water): 0.05 log POW (calculated)

Viscosity:

Dynamic at 20°C: 4.72 mPas

Other information: No further relevant information available.

Form: Liquid

10 Stability and reactivity

Reactivity :

Chemical stability :

Thermal decomposition / conditions to be avoided :

No decomposition if used according to specifications.

Possibility of hazardous reactions :

Violent reactions possible with Strong oxidising agents, strong reducing agents, alkalines, acids

Conditions to avoid :

Extreme heat

Incompatible materials :

Strong oxidising agents, strong reducing agents, alkalines, acids

Hazardous decomposition products:

May produce carbon mono-oxide and/or carbon dioxide

11 Toxicological information

LD/ LC 50 values relevant for classification

Oral LD 50 150 mg/kg (mouse)

200 mg/kg (rat)

Primary irritant effect:

On the skin: Strong caustic effect on skin and mucous membranes.

On the eye: Strong caustic effect.

Sensitization: No sensitizing effects known

Additional toxicological information:

Swallowing will lead to a strong caustic effect on mouth and throat and to the danger of perforation of

esophagus and stomach.

CMR effects (carcinogenity, mutagenicity and toxicity for reproduction)

Not listed as a carcinogen by ACGIH, IARC, NIOSH, NTP, OSHA, or CA Prop 65

Mutagenicity: The substance was found to be non-mutagenic as per Ames test.

Information on toxicological effectsAcute Toxicity

12 Ecological Information

Toxicity

Acquatic toxicity:

Quantitative data on the ecological effect of this product are not available.

Persistence and degradability:

No further relevant information available.

Behaviour in environmental systems:

Bioaccumulative potential

Behaviour in environmental systems:

Bioaccumulation Estimates from Log Kow (BCFWIN v2.17):

Log BCF from regression-based method = 0.500 (BCF = 3.162)

log Kow used: 0.05 (estimated)

Mobility in soil

Soil Adsorption Coefficient (PCKOCWIN v1.66):

Koc : 10

Log Koc : 1.000

Additional ecological information:

General notes:

Water hazard class 3 (German Regulation) (Self-assessment): extremely hazardous for water.

Do not allow product to reach ground water, water course or sewage system, even in small quantities.

Must not reach sewage water or drainage ditch undiluted or unneutralized.

Danger to drinking water if even extremely small quantities leak into the ground.

Results of PBT and vPvB assessment :

PBT : Not applicable.

vPvB : Not applicable.

Other adverse effects : No further relevant information available

13 Disposal considerations

Waste treatment methods

Recommendation: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed

professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent

and burn in a chemical incinerator equipped with an afterburner and scrubber.

Uncleaned packaging:

Recommendation: Disposal must be made according to official regulations.

14 Transport Information

UN-Number:

ADR, IMDG, IATA: UN2922

UN proper shipping name :

ADR 2922 CORROSIVE LIQUID, TOXIC, N.O.S. (ethyl 4-chloroacetoacetate)

IMDG, IATA CORROSIVE LIQUID, TOXIC, N.O.S. (ethyl 4-chloroacetoacetate)

Transport hazard class(es)

ADR

Class: 8 Corrosive substances

Label: 8+6.1

IMDG, IATA

Class: 8 Corrosive substances

Label: 8+6.1

Packing group:

ADR, IMDG, IATA II

Environmental hazards

Marine pollutant: No

Special precautions for user: Warning: Corrosive substances

Danger code (Kemler): 886

EMS Number: F-A, S-B

Transport in bulk according to Annex II

of MARPOL73/78 and the IBC Code : Not applicable

Transport/Additional information:

ADR

Tunnel restriction code: E

UN "Model Regulation": UN2922, CORROSIVE LIQUID, TOXIC, N.O.S. (ethyl 4- chloroacetoacetate), 8 (6.1), II

15 Regulatory Information

Hazard pictograms Please refer section 2

Single word Danger

Hazard statements Please refer section 2

Precautionary statements Please refer section 2

Chemical safety assessment:

A Chemical Safety Assessment has not been carried out and shall be available at the time of REACH registration.

Safety, health and environmental regulations/legislation specific for the substance or mixtureLabelling according to regulation (EC) No 1272/2008

16 Other Information

Abbreviations and acronyms

ADR : Accord européen sur le transport des marchandises dangereuses par Route (European Agreement

concerning the International Carriage of Dangerous Goods by Road)

RID : Règlement international concernant le transport des marchandises dangereuses par chemin de fer

(Regulations Concerning the International Transport of Dangerous Goods by Rail)

IMDG : International Maritime Code for Dangerous Goods

IATA : International Air Transport Association

ICAO : International Civil Aviation Organization

GHS : Globally Harmonized System of Classification and Labelling of Chemicals

EINECS : European Inventory of Existing Commercial Chemical Substances

CAS : Chemical Abstracts Service (division of the American Chemical Society)

LC50 : Lethal concentration, 50 percent

LD50 : Lethal dose, 50 percent

This information is based on our present knowledge. However, this shall not constitute a guarantee for any specific

product features and shall not establish a legally valid contractual relationship.

.

REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL on classification,

labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/ EEC and

1999/45/EC, and amending Regulation (EC) No 1907/2006

Data is from MSDS of Merck KGaA

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tSKU=MDACHEM-818571&DocumentType=MSD&DocumentId=& DocumentSource=&

Country=GLOBAL&Channel=Merck- International-Site&Language=EN

Data is from MSDS of Sigma Aldrich (Product ID: Aldrich - 690295)

http://www.sigmaaldrich.com/MSDS/MSDS/

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*Data compared to the previous version altered.

Section 2 : Hazard Identification

Section 4 : First-aid measures

Section 6 : Accidental Release Measures

Section 7 : Handling and Storage

Section 8 : Exposure Controls / Personal Protection

Section 10 : Stability and Reactivity

Section 11 : Toxicological Information

Section 12 : Ecological Information

Section 13 : Disposal Considerations

Section 14 : Transport Information

Section 15 : Regulatory Information

Sources

Ethyl-4-chloroacetoacetate

(E4CAAE)

CAS No. 638-07-3

HS Code 2918 30 90

EINECS No. 211-317-0

Synonyms 4-Chloro-3-oxobutanoic Acid ethyl ester Ethyl 3-oxo-4-chlorobutanoate Ethyl 4-chloro-3-oxobutanoate Molecular Formula C6H9ClO3

Chemical Structure

Molecular Weight 164

Quality

Parameter Specification

Colour Colourless to yellowish

Consistency Clear Liquid

Moisture Content %, max 0.1

Purity (by GC), % area, min 98

Packaging Bulk Tankers, 200kg HMHDPE Drums Application Medicine and pesticide intermediate Country of Origin India

For further information please visit www.laxmiorganic.co.in or send an enquiry to [email protected]

Issue Date :14.10.2014