LA POLIFARMACOTERAPIA: STATO DELL’ARTE FEDERICO PEA ISTITUTO DI FARMACOLOGIA CLINICA PRESIDIO OSPEDALIERO UNIVERSITARIO SM MISERICORDIA ASUI UDINE Udine, 05 Dicembre 2017 GIORNATA REGIONALE DELLA SICUREZZA E QUALITA’ DELLE CURE 2017
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LA POLIFARMACOTERAPIA: STATO DELL’ARTE
FEDERICO PEA
ISTITUTO DI FARMACOLOGIA CLINICA
PRESIDIO OSPEDALIERO UNIVERSITARIO SM MISERICORDIA
ASUI UDINE
Udine, 05 Dicembre 2017
GIORNATA REGIONALE DELLA SICUREZZA E QUALITA’ DELLE CURE 2017
Istituto di Farmacologia Clinica - UniUD
Ippocrate (460 - 335 a.C.)
“PRIMUM NON NOCERE”
POLYTHERAPY AND THE RISK OF POTENTIALLY INAPPROPRIATE PRESCRIPTIONS (PIPS) AMONG ELDERLY AND VERY ELDERLY PATIENTS
IN THREE DIFFERENT SETTINGS OF THE FRIULI VENEZIA GIULIA REGION, ITALY Cojutti PG, Arnoldo L, Cattani G, Brusaferro S, Pea F
Pharmacoepidemiol Drug Safety 2016 Sep;25(9):1070-8.
PATIENTS’ CHARACTERISTICS
FACTORS ASSOCIATED AT MULTIVARIATE ANALYSIS WITH POTENTIALLY INAPPROPRIATE PRESCRIPTION (PIP)
POLYTHERAPY AND THE RISK OF POTENTIALLY INAPPROPRIATE PRESCRIPTIONS (PIPS) AMONG ELDERLY AND VERY ELDERLY PATIENTS
IN THREE DIFFERENT SETTINGS OF THE FRIULI VENEZIA GIULIA REGION, ITALY Cojutti PG, Arnoldo L, Cattani G, Brusaferro S, Pea F
Pharmacoepidemiol Drug Safety 2016 Sep;25(9):1070-8.
EXAMPLES OF POTENTIALLY INAPPROPRIATE PRESCRIPTIONS OUTSIDE OF THOSE CONTEMPLATED BY THE BEERS CRITERIA
POLYTHERAPY AND THE RISK OF POTENTIALLY INAPPROPRIATE PRESCRIPTIONS (PIPS) AMONG ELDERLY AND VERY ELDERLY PATIENTS
IN THREE DIFFERENT SETTINGS OF THE FRIULI VENEZIA GIULIA REGION, ITALY Cojutti PG, Arnoldo L, Cattani G, Brusaferro S, Pea F
Pharmacoepidemiol Drug Safety 2016 Sep;25(9):1070-8.
• Controindicazioni:
• Claritromicina
• Gemfibrozil
• Voriconazolo
• Posaconazolo
• Succo di pompelmo
• Non superare 20 mg/die con:
• Amlodipina
• Ranolazine
• Non superare 10 mg/die con:
• Amiodarone
• Verapamil
• Diltiazem
Interazioni farmacologiche
Simvastatina
• Controindicazioni relative:
• Claritromicina
• Gemfibrozil
• Amiodarone
• Verapamil
• Diltiazem
• Amlodipina
• Voriconazolo
• Posaconazolo
• Succo di pompelmo
Atorvastatina
Istituto di Farmacologia Clinica - UniUD
EXAMPLES OF POTENTIALLY INAPPROPRIATE PRESCRIPTIONS OUTSIDE OF THOSE CONTEMPLATED BY THE BEERS CRITERIA
POLYTHERAPY AND THE RISK OF POTENTIALLY INAPPROPRIATE PRESCRIPTIONS (PIPS) AMONG ELDERLY AND VERY ELDERLY PATIENTS
IN THREE DIFFERENT SETTINGS OF THE FRIULI VENEZIA GIULIA REGION, ITALY Cojutti PG, Arnoldo L, Cattani G, Brusaferro S, Pea F
Pharmacoepidemiol Drug Safety 2016 Sep;25(9):1070-8.
Algoritmo per la deprescrizione degli inibitori di pompa protonica (PPI)
Algoritmo per la deprescrizione delle benzodiazepine
Algoritmo per la deprescrizione degli antipsicotici
Algoritmo per la deprescrizione degli ipoglicemizzanti
Algoritmo per la deprescrizione degli inibitori di pompa protonica (PPI)
DISTRIBUTION (%) OF THE 10 DRUGS MOST FREQUENTLY PRESCRIBED IN THE DIFFERENT SETTINGS ACCORDING TO THE ATC CLASSIFICATION
POLYTHERAPY AND THE RISK OF POTENTIALLY INAPPROPRIATE PRESCRIPTIONS (PIPS) AMONG ELDERLY AND VERY ELDERLY PATIENTS
IN THREE DIFFERENT SETTINGS OF THE FRIULI VENEZIA GIULIA REGION, ITALY Cojutti PG, Arnoldo L, Cattani G, Brusaferro S, Pea F
Pharmacoepidemiol Drug Safety 2016 Sep;25(9):1070-8.
Institute of Clinical Pharmacology - UniUD
Institute of Clinical Pharmacology - UniUD
Algoritmo per la deprescrizione degli inibitori di pompa protonica (PPI)
Algoritmo per la deprescrizione delle benzodiazepine
Algoritmo per la deprescrizione degli antipsicotici
Algoritmo per la deprescrizione degli ipoglicemizzanti
Algoritmo per la deprescrizione delle benzodiazepine
DISTRIBUTION (%) OF THE 10 DRUGS MOST FREQUENTLY PRESCRIBED IN THE DIFFERENT SETTINGS ACCORDING TO THE ATC CLASSIFICATION
POLYTHERAPY AND THE RISK OF POTENTIALLY INAPPROPRIATE PRESCRIPTIONS (PIPS) AMONG ELDERLY AND VERY ELDERLY PATIENTS
IN THREE DIFFERENT SETTINGS OF THE FRIULI VENEZIA GIULIA REGION, ITALY Cojutti PG, Arnoldo L, Cattani G, Brusaferro S, Pea F
Pharmacoepidemiol Drug Safety 2016 Sep;25(9):1070-8.
Institute of Clinical Pharmacology - UniUD
Institute of Clinical Pharmacology - UniUD
Institute of Clinical Pharmacology & Toxicology – University Hospital of Udine
William Osler (1849 - 1919)
"One of the first duties of the physician is to educate
the masses not to take medicine"
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