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Kuliah KlarifikasiNursing Care of Patients withHIV/AIDS
Kuswantoro Rusca Putra, S.Kp.,M.Kep
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Anatomic of The Immune System
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Physiology of The Immune System
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Understanding The Immune System
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HIV Antibody Tests
Enzyme-linked immunosorbent assay (ELISA)
test
Western blot testComplete Blood Cell Count/Lymphocyte Count
CD4+ (410 - 1590 sel/ul)
CD8+ (190 - 1140 sel/ul)
Viral Load Testing
100.000 copies/mlhigh risk for AIDS
Laboratory Testing & Diagnostic
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Five Goals of ART
Decrease the amount of virus in theblood.
Support and help the immune system.
Improve quality of life.
Reduce HIV-related illness and death.
Possibly reduce transmission of HIV to
others.
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Nucleoside (and nucleotide) reversetranscriptase inhibitors (NRTIs):
NTRIs inhibit the transcription (change) of
viral RNA into DNA, thereby interfering withviral replication.
Non-nucleoside reverse transcriptase
inhibitors (NNRTIs):
NNRTIs also inhibit the transcription of viralRNA into DNA, but they are chemically
different than NRTIs.
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Protease inhibitors (PIs):
PIs block protease, an enzyme that HIV
requires for replication.
Fusion inhibitors:
Fusion inhibitors disrupt the interaction
between the HIV virus and the cell surface,
preventing the fusion of the HIV virus to the
cell.
These drugs are not widely available and
cannot be taken by mouth.
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ARV drugs
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Medications for HIV Infection
Medication Class Action
Nonnucleoside reversetranscriptase inhibitors
(NNRTIs)
Block active site of HIV reversetranscriptase
Nucleoside/Nucleotide
Reverse
Transcriptase Inhibitors(NRTIs)
Inhibit production of reverse transcriptase
and viral replication
Protease Inhibitors (PIs) Bind to active site of HIV protease enzyme,
which cuts reproduced HIV strands.Interrupt
formation of mature viral particles and
reduceviral replication. Rapid resistance
development if not taken as directed
Fusion Inhibitors Blocks HIV-1 fusion with the CD4+cell
membrane to prevent cell entry
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Cairan
Estimasi rata-rata tubuh orang dewasa akankehilangan 2.5 L cairan per harinya :
Sekitar 1.5 L cairan tubuh keluar melalui urin,
500 ml melalui keluarnya keringat, 400 ml keluar dalam bentuk uap air melalui
proses respirasi (pernafasan) dan
100 ml keluar bersama dengan feces (tinja).
Sehingga berdasarkan estimasi ini, konsumsi
antara 8-10 gelas (1 gelas 240 ml)
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Macro Mineral
Kalsium (Ca)
Fosfor (P)
Magnesium (Mg)
Sulfur (S) Kalium (K)
Klorida (Cl)
Natrium (Na)
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Micro Mineral
Kromium (Cr)
Tembaga (Cu)
Fluoride (F)
Yodium (I) Besi (Fe)
Mangan (Mn)
Silisium (Si) Seng (Zn))
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Natrium (Na)
Minimum kebutuhan untuk orangdewasa berkisar antara 1.3-1.6 gr/hari
(ekivalen dengan 3.3-4.0 gr
NaCl/hari). konsentrasi berkisar antara 135-145
mmol/L. Io
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Kalium (K)
Konsentrasi antara 3.5-5.0 mmol /L.
Kebutuhan minimum kalium
diperkirakan sebesar 782 mg/hari
Konsentrasi total kalium di dalamtubuh diperkirakan sebanyak 2g/kg
berat badan. Nam
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Klorida (Cl)
Dalam jaringan tubuh diperkirakansebanyak 1.1 g/ Kg berat badan
Konsentrasi antara 98-106 mmol / L
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The Cycle of Malnutrition & Infection
in the context of HIV/AIDS
I l i Eff t f S ifi
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Immunologic Effects of Specific
Micronutrient Deficiences
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Body Mass Indeks
BMI =
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Kategori BMI
Kurus Kekurangan BB Berat < 17
Kekurangan BB
Ringan
17 18,4
Normal 18,5 - 25
Gemuk Kelebihan BB Ringan > 25 - 27
Kelebihan BB Berat > 27
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Cara Menghitung Kebutuhan
Kalori BB Idaman x Keb. Kalori BB IdamanAktivitas Ringan Sedang Berat
Gemuk 25 30 35
Normal 30 35 40
Kurus 35 40 40 - 50
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Nursing Diagnosis
Risk for infection related to decreasedimmune function
Impaired gas exchange related to respiratory
infection Acute or chronic pain related to neuropathy,
cancer, infection, or dyspnea
Fatigue related to HIV infection and/or side
effects of treatments
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Diarrhea
DEFINITION: Passage of loose, unformed stools
Related factors Infectious processes,medications
SubjectiveAbdominal pain
Urgency, cramping
Objective
Hyperactive bowel sounds
At least three loose liquid stools per day
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DESIRED OUTCOMES/EVALUATION
CRITERIA
Client Will (Include Specific Time Frame)
Reestablish and maintain normal pattern of
bowel functioning.
Verbalize understanding of causative factorsand rationale for treatment regimen.
Demonstrate appropriate behavior to assist
with resolution of causative factors (e.g.,
proper food preparation or avoidance ofirritating foods).
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risk for deficient Fluid VolumeDEFINITION: At risk for experiencing vascular, cellular, or intracellular
dehydration
RISK FACTORS
Excessive losses through normal
routes (e.g., diarrhea)
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DESIRED OUTCOMES/EVALUATION
CRITERIA
Client Will (Include Specific Time Frame)
Maintain fluid volume at a functional level
as evidenced by individually adequate
urinary output with normal specific gravity,stable vital signs, moist mucous
membranes, good skin turgor, and prompt
capillary refill
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Client/Caregiver Will (Include Specific TimeFrame)
Identify individual risk factors and appropriate
interventions.
Demonstrate behaviors or lifestyle changes to
prevent development offluid volume deficit.
DESIRED OUTCOMES/EVALUATION
CRITERIA
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risk for Electrolyte ImbalanceDEFINITION: At risk for change in serum electrolyte levels that may
compromise health.
RISK FACTORS
Fluid imbalance (e.g., dehydration,
water intoxication); diarrhea; vomiting
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DESIRED OUTCOMES/EVALUATION
CRITERIA
Client Will (Include Specific Time Frame) Display laboratory results within normal
range for individual.
Be free of complications resulting fromelectrolyte imbalance.
Identify individual risks and engage in
appropriate behaviors or lifestyle changes
to prevent or reduce frequency ofelectrolyte imbalances.
imbalanced Nutrition: less than body
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imbalanced Nutrition: less than body
requirementsDEFINITION: Intake of nutrients insufficient to meet metabolic
needs
RELATED FACTORS
Inability to ingest or digest food; inability to
absorb nutrients
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SubjectiveReported food intake less than RDAs
(recommended daily allowances); lack of
food Lack of interest in food; aversion to
eating; reported altered taste sensation;
perceived inability to digest food
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Objective Loss of weight with adequate food intake
Hyperactive bowel sounds; diarrhea
Poor muscle tone
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Objective [Abnormal laboratory studies (e.g., decreased
albumin, total proteins; iron deficiency;
electrolyte imbalances)]
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DESIRED OUTCOMES/EVALUATION
CRITERIA
Client Will (Include Specific Time Frame) Demonstrate progressive weight gain
toward goal.
Display normalization of laboratory valuesand be free of signs of malnutrition
Verbalize understanding of causative
factors when known and necessary
interventions. Demonstrate behaviors, lifestyle changes to
regain or maintain appropriate weight.
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risk for InfectionDEFINITION: At increased risk for being invaded by pathogenic
organisms
RISK FACTORS Inadequate primary defenses (broken skin,
traumatized tissue, decrease in ciliary
action,stasis of body fluids, change in pH
secretions, altered peristalsis)
Inadequate secondary defenses (e.g.,
decreased hemoglobin, leukopenia,
suppressed inflammatory response) Inadequate acquired immunity;
immunosuppression
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Client Will (Include Specific Time Frame) Verbalize understanding of individual
causative or risk factor(s).
Identify interventions to prevent or reducerisk of infection.
Demonstrate techniques, lifestyle changes
to promote safe environment.
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FatigueDEFINITION: An overwhelming sustained sense of exhaustion and
decreased capacity for physical and mental work at usual level
SubjectiveVerbalization of an unremitting or overwhelming
lack of energy; inability to maintain usual
routines or level of physical activity
Perceived need for additional energy to
accomplish routine tasks; increase in rest
requirements
Tired; inability to restore energy even after sleep
Feelings of guilt for not keeping up with
responsibilities
Increase in physical complaints
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Objective Lethargic; listless; drowsy; lack of
energy
Decreased performance,
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Client Will (Include Specific Time Frame) Report improved sense of energy.
Identify basis of fatigue and individual areas
of control. Perform activities of daily living (ADLs) and
participate in desired activities at level of
ability.
Participate in recommended treatmentprogram.
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Activity IntoleranceDEFINITION: Insufficient physiological or psychological energy to endure or
complete required or desired daily activities
SubjectiveVerbal report of fatigue, weakness
Exertional discomfort, dyspnea
[Verbalizes no desire for and/or lack of interest inactivity]
Objective
Abnormal heart rate or blood pressure responseto activity
Electrocardiographic changes reflecting
arrhythmias or ischemia [Pallor, cyanosis]
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Client Will (Include Specific Time Frame) Identify negative factors affecting activity
tolerance and eliminate or reduce their effects
when possible.
Use identified techniques to enhance activity
tolerance.
Participate in necessary/desired activities.
Report measurable increase in activity tolerance. Demonstrate a decrease in physiological signs of
intolerance (e.g., pulse, respirations, and blood
pressure remain within clients usual range).
ne ec ve am y erapeu c eg men
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y p gManagementDEFINITION: Pattern of regulating and integrating into family processes a
programfor treatment of illness and the sequelae of illness that is
unsatisfactory for meeting specific health goals
Subjective Verbalizes difficulty with therapeutic regimen
Verbalizes desire to manage the illness
Objective
Inappropriate family activities for meeting
health goals
Acceleration of illness symptoms of a family
member
Failure to take action to reduce risk factors;