Kuliah Fts Csp 27 Feb 2012

7/18/2019 Kuliah Fts Csp 27 Feb 2012

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FORMULASI TEKNOLOGISEDIAAN CAIR DAN SEMI

PADATKuliah tanggal 27 Februari

2!2



• Se"iaan #e$i%a"at ber#i&at' "a%at$ele(at %a"a %er$u(aan te$%at%e$a(aian "ala$ )a(tu *ang +u(u%la$a #ebelu$ #e"iaan "i+u+i,

• Ma+a$-$a+a$ #e"iaan #e$i %a"at'#ale%. %a#ta. +rea$. gel



• Perbe"aann*a /

• Sale% ' #e"iaan #e$i %a"at *ang ter"iri "ari(0$%0nen ba#i# *ang "a%at beru%a ba#i#

larut air 1%0lietilengli(0lPEG3. atau ba#i#berle$a(. #e%erti $in*a( $ineral. %etr0latu$

• Pa#ta' #e"iaan #e$i %a"at *ang $engan"ung

4at %a"at *ang ti"a( larut "ala$ (0n#entra#i*ang tinggi. 4at %a"at ter#ebut "a%atter"i#%er#i "ala$ %e$ba)an*a



• Kri$ ' #e"iaan #e$i%a"at "engan #i#te$ e$ul#i*ang ti"a( 5ernih. ti"a( te$bu# +aha*a.(0n#i#ten#in*a tergantung %a"a ti%e e$ul#in*a

• Gel ' #e"iaan #e$i %a"at *ang &a#e +airn*a "ibentu("ala$ $atri6 %0li$er tiga "i$en#i *ang $e$%un*aii(atan #i( atau (i$ia)i *ang tinggi

• C0nt0h %0li$ern*a' - %0li$er ala$ 1 g0$. traga(an.

%e(tin. agar. a#a$ alginat3. "an %0li$er#e$i#i#nteti( atau #inteti( 1$etil #elul0#a.(arb0(#i$etil#elul0#a. hi"r0(#i $etil #elul0#a.+arb0%0l3



Mengenal #tru(tur (ulit



Mengenal 5alur tran#%0rta#i 0bat$elalui (ulit 15alur e%i"er$al3



8alur a%%en"ageal



9ang %erlu "i%erhati(an "ala$&0r$ula#i #e"iaan t0%i(al

'

!, Kara(teri#ti( #i(0(i$ia bahan a(ti& *ang $eli%uti'

- (elarutan

- (0e#ien %arti#i 4at a(ti&. %erban"ingan (elarutan 0bat

"ala$ li%i" "iban"ing(an (elarutann*a "ala$ air 1l0g P#ebai(n*a !-:3. untu( #e"iaan t0%i(al. bahan-bahan"ala$ #e"iaan haru# "a%at ber%enetra#i (e "ala$ (ulit.%erlu "i%erhati(an #i&at 1li%0li#ita# (ulit3

- titi( leleh. #ebai(n*a (urang "ari 2 "era5at C.

- "era5at (ea#a$an 1%Ka3. a(an $e$%engaruhi 5u$lah 4ata(ti& *ang teri0n atau *ang a"a "ala$ bentu( $0le(ul3.berhubungan "engan ban*a(n*a 4at a(ti& *ang "a%at$ene$bu# $e$bran (ulit



2, Kara(teri#ri( #i( bahan a(ti& - )arna. bau. ra#a

- u(uran $0le(ul 1b0b0t $0le(ul. ; < Dalt0n3."an "i#tribu#i u(uran %arti(el

-"en#ita#

-=i#(0#ita#

:, Stabilita# (i$ia. #i(a. "an $i(r0bi0l0gi

>, T0(#i#ita# 4at a(ti&

<, "ata bi0&ar$a#i 1"i#0lu#i. ab#0rb#i. $etab0li#$e.bi0a=ailabilit*. )a(tu %aruh eli$ina#i3

?, Si&at bahan ta$bahan



Pr0#e# *ang ter5a"i 1%a"a%enggunaan #e"iaan t0%i(al3

• !, "i&u#i 4at a(ti& "ari &0r$ula atau#e"iaann*a $ene$bu# (ulit

• 2, 4at a(ti& ber%arti#i (e "ala$ (ulit$elalui #tartu$ (0rneu$



• Se#uai "engan %er#a$aan St0(e#-Ein#tein# %a"a %er#a$aan,

• R T

• D @ ,,,,,,,,,,,,,,,,,,,,,,,,,,,,

• ? B r N



• (eterangan ' D@ Di&u#ita# 1+$2 "t(-!3

• R@ K0n#tante ga# i"eal 1erg $0l-

!"era5at-!3

• T@ #uhu $utla( 1Kel=in3

• @ =i#(0#ita# 1"*ne +$-23

• R@ 5ari-5ari $0le(ul 1+$$0le(ul3

• N@ bilangan A=0ga"r0 1?.2 !2: $0le(ul$0l3

•



• Perlu "i%erhati(an '

• !, 5u$lah 4at a(ti& *ang a"a "ala$ &0r$ula.#e$a(in ban*a( a(an #e$a(in ban*a( %ula

*ang "a%at $en+a%ai #tratu$ (0rneu$.#a$%ai "i%er0leh (0n#entra#i 5enuh

• 2, P0larita# &0r$ula#i relati& terha"a%#tratu$ (0rneu$. *ang "ihara%(an *aitu

4at a(ti& "ala$ (0#$eti( lebih $u"ah larut"ala$ #tratu$ (0rneu$ "iban"ing(an "i"ala$ &0r$ulan*a



8eni# bahan Pe$ba)a

• !, a#i# hi"r0(arb0n – -#u(ar "i+u+i

– Da%at $engurangi %engua%an

(ele$ba%an %a"a (ulit

– C0nt0h %etr0latu$ 1$u"ah $en*ebar#aat "iguna(an "i (ulit. luna(3



• 2, ba#i# #era% – -"ibentu( "ari (0$bina#i hi"r0(arb0n

"engan #en*a)a *ang ber#i&at hi"r0l

1$i#al #en*a)a *ang $e$%un*ai gugu#%0lar. #e%erti #ul&at. (arb0(#il. hi"r0(#il.#ter0l. #0rbitan $0n0#tearat3

– 8i(a "i#entuh #ebenarn*a ti"a($en*era% air. ta%i "engan %enga"u(an."a%at $en*era% larutan air 1"a%at$e$bentu( e$ul#i air "ala$ $in*a(3



• :, a#i# *ang "a%at "i+u+i "engan air

– A"alah e$ul#i $in*a( "ala$ air 1(ri$3. =ani#hing(ri$

– Da%at "iguna(an %a"a lu(a *ang ba#ah. "engan#i#te$ e$ul#i $in*a( "ala$ air $e$%un*ai(e$a$%uan $en*era% +airan *ang "i(eluar(an0leh lu(a

– 8i(a "iguna(an "a%at $e$bentu( la%i#an ti%i#

#e$i%er$eabel 1#etelah air $engua% %a"ate$%at *ang "iguna(an3. ta%i (alau e$ul#i air"ala$ $in*a( "ari #e"iaan #e$i%a"at a(an$e$bentu( la%i#an hi"r0&0bi( %a"a (ulit,



• >, a#i# *ang larut "ala$ air 1ti"a($engan"ung le$a(3 – a#i# ter"iri "ari (0$bina#i

%0lietilengli(0l 1PEG3"engan M tinggi1%a"at3"an PEG "engan M ren"ah1+air3

–

Si&at "a%at larut "ala$ air (arena a"agugu# %0lar "an i(atan eter

– Ru$u# u$u$'

– HOCH2CH2OCH2JnCH2OH



Perhitungan "i#0lu#i #ale%

Kuliah Fts Csp 27 Feb 2012

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