Kim Solez Regenerative Medicine II when the wild west period will end

Regenerative Medicine Part II: When Will the Current

“Wild West” period End and What Should We Do In The

Meantime?Kim Solez, MD

Analogy between the start of clinical transplantation and the start of clinical regenerative medicine.

In transplantation a “wild west “ period between the first transplant in 1954 and advent of cyclosporine in 1983.

One might image with exponential change 30 years might become 3!

Moore’s Law Muted in Medicine! Might Take Longer for “Wild West” to End.

Regulatory oversight that is completely focused on compliance. Discourages risk-taking and innovation.

Health care doesn't have the same financial reward system. Facebook isn't about to pay $1 billion for the latest hot-ticket item in imaging and informatics.

Security always trumps information sharing, and so better, faster linkages are constrained because of security concerns, most of which are bogus.

Moore’s Law Muted in Medicine!

Difficult to Know Where to Draw Line in Sand. Twenty Cell Types in Kidney, Including Cells Making Renin and Renal Erythropoietic Factor. How Many Do We Need to Get Right and To What Extent?

We Do Not Need To Feel Embarrassed If Classification Reflects “Wild West”. Current Transplantation Classification Contains Old Entities Like Hyperacute Rejection and Perfusion Injury.

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Hyperacute Rejection is Similar to Regenerative Medicine Attempts with Vessels Lacking Endothelium, Both Types of Organs “Clot Like Crazy” n

I Wrote a Poem About All This, Or Rather A Poem Wrote Itself

The Discovery of Papilla As Likely Stem Cell Niche in Kidney Also Harkens Back to Older Times!

Papillary Necrosis Due To Analgesic Abuse was a Big Deal in the 60s and 70s but Now Has Disappeared.

High Point from Latest Cell Therapy Regenerative Medicine Society (CTRMS) Meeting

Khouloud Saliba and I Presented at TERMIS (Regenerative Medicine) Meeting in San Diego Dec. 11-14, 2016.

Met Astgik Petrosyan Who Has Written About the Many Additional Variables Which Will Add Complexity to New Banff Classification

Decellularized Renal Matrix and Regenerative Medicine of the Kidney: A Different Point of View Petrosyan Astgik, … and Perin Laura. Tissue Engineering Part B: Reviews. May 2016, 22(3): 183-192. 

A Step Towards Clinical Application of Acellular Matrix: A Clue from Macrophage Polarization. Petrosyan A, …Perin L. Matrix Biol. 2016 Aug 26. pii: S0945-053X(16)30133-0.

Astgik Petrosyan Variables Will Necessitate AI Approaches to New Banff Classification!

Originally we had mule deer poking their heads into the

meeting rooms. Now we have real data complexity but

outcome should be very good for patients. We’ve come a long

way!