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J. Med., 65: 584-592, 1978.19) Rettig, P.J.: Campylobacter infections in
human beings. J. Pediatrics, 94: 855-864, 1979.
276 感染症学雑誌 第60巻 第3号
Two Cases of Campylobacter fetus Meningitis
Yube IIDA,Kunihiko SUNAGA,Keigo MAEHARA,Yuruko OKAMOTO & Kojiro YASUNAGAInternal Medicine Kansai Medical University
Keiko NISHIURA
Second Medicine Kansai Medical UniversityKenji SHIMOSHIKIRYO
Department of Clinical Laboratory
Two cases of Campylobacter fetus Meningitis without underlying diseases were reported. Case 1.A-42-year-old man had high fever and headache in December,1977.He was treated by personal physician,but he complained nausea, vomiting and tinnis.He was admitted to the Kansai Medical University on
January 17,1978.The CSF findings showed that initial pressure was 190mm H2O,cell count was960/3mm3(all lymphocyte),protein level was 130mg/dl,glucose level was 37mg/dl,and tryptophan testwas positive.He was treated with Isoniazide,Streptomycin and Rifampicin for suspected tuberclousmeningitis.But Campylobacter fetus subsp.fetus(C.fetus)was isolated from CSF.It was sensitive to ABPC,MINO,TC,CP,and aminoglycosides.We used MINO 200 mg/day for 6 weeks.The patient wasdischarged as recovered in March,1978.Stool and blood culture were negative for C.fetus.The patientdid not have a history contact with animals.The infection route was not detected.Case 2.A-30-year-oldman admitted on November,15,1983 because high fever and headache.Two weeks earlier he ate raw
beef liver with his friend.His conciousness was clear but neck stiffness was present.The CSF findingsshowed that turbirity was positive,initial pressure was 170mm H2O,cell count was 129mg/dl,and
glucose level was 65mg/dl.We found gram-negative spinal rods in gram stain,and C.fetus was isolatedfrom CSF.Rokitamycin 1200 mg/day was orally administered,but fever and headahe continued.CSFand serum levels of Rokitamycin(300 mg orally administered)were measured.Serum peak level was0.625,ug/ml at 2 hours,but CSF levels were lower than measurable level.It was sensitive to AB PC,MINO,EM,TC,and aminoglycosides.We used AB PC 12g/day intravenously and TOB 5mg/day in-trathecally twice a week for 4 weeks.He was discharged as recovered on January,1984.He ate raw beefliver,but his blood and stool culture for C.fetus were negative. And stool culture for C.fetus of his friendwas negative.