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Key topic summary• Classification of Pesticides• Organophosphorous PesticidesGeneral structure, mechanism of action, clinical signs, treatment.
Organophosphates vs. Carbomates
• OrganochlorinesExamples, mechanism of action, clinical signs, treatment
• HerbicidesExamples, mechanism of action, clinical signs, treatment
• Fungicides and FumigantsExamples, toxic effects
PESTICIDES
Alexander V. Lyubimov, M.D., Ph.D.
DirectorToxicology Research Laboratory
Department of PharmacologyUniversity of Illinois at Chicago
Pesticide is a substance or mixture of substances intended for preventing, destroying, repelling, or mitigating any pest (US EPA).
Pest includes harmful, destructive, or troublesome animals, plants, or microorganisms.
APPLICATORS ONLY?
Are there ANY other populations
(besides occupationally exposed) who can be poisoned by
PESTICIDES?
HOW WE CAN SURVIVE IT?
NO-EFFECT-LEVEL (NOEL) in animals
is used to determine:Residue Tolerance Limits
maximum safe levels of pesticide in food
PESTICIDES CLASSIFICATION1.Insecticides
1.1 Organophosphates (most are actually thiophosphates)1.2 Carbamates1.3 Organochlorines1.4 Botanical compounds