Kevin Harris. .

Buruli UlcersKevin Harris

Buruli Ulcers are an Emerging Tropical Infectious Disease

http://reliefweb.int/sites/reliefweb.int/files/resources/map_1281.pdf

Buruli Ulcers are a Neglected Infectious Disease

* 15.6 Billion Dollars on HIV/AIDS Research in 2008

http://www.ncbi.nlm.nih.gov/books/NBK62528/

How do you get Buruli Ulcers?

http://www.thenational.ae/thenationalconversation/industry-insights/energy/a-boom-and-a-test-for-ghana

http://science.howstuffworks.com/environmental/life/zoology/insects-arachnids/mosquito.htm

M. Ulcerans Lives in the Skin and Subcutaneous Tissues

http://web.archive.org/web/20080612093735/http://training.seer.cancer.gov/ss_module14_melanoma/images/illu_skin01.jpg

M. Ulcerans Secretes a Necrotizing, Immunosuppressive Toxin

Mycolactone (A polyketide-derived macrolide toxin)

http://www.biomedcentral.com/1471-2164/9/462/figure/F3?highres=y

Mycolactone Promotes Apoptosis and Inhibits Immune Responses

http://www.sciencedirect.com/science/article/pii/S0092867411012839

Buruli Ulcers Vary Greatly in Severity

http://en.wikipedia.org/wiki/Buruli_ulcer

With Current Technologies Buruli Ulcers Can be Difficult to Diagnose

6-8 Weeks20-60% Effective

Immediate Results40% Effective

http://www.scientificamerican.com/blog/post.cfm?id=genetic-survey-finds-healthy-human-2009-05-28http://hscweb3.hsc.usf.edu/health/now/wp-content/GHIDR_Kyle_Microscope.jpg

With Current Technologies Buruli Ulcers Can be Difficult to Diagnose

Immediate Results90% EffectiveRequires Tissue Biopsies

Results Within 2 Days98% Effective

http://www.wisbiomed.com/ec/images/mix500-new.jpg

Antibiotics are the First Line Treatment for Buruli Ulcers

Binds 50s Subunit Binds 30s subunit

http://www.royce-pharma.com/rifampicin-150-capsule/

http://www.webmd.com/drugs/image.aspx?drugid=11249&drugname=Streptomycin+IM&title=STREPTOMYCIN+SULF+1+GM+VIAL&monoid=39822070602&cb=mywebmd

In Severe Cases Surgical Excision may be Necessary

Osteomyelitis

http://en.wikipedia.org/wiki/File:Healed_Buruli_ulcer_lesions.jpghttp://undernewskies.wordpress.com/2011/05/23/evil-ulcers/

Heat Therapy is a Possible Future Treatment

Sources

"Buruli Ulcer Disease." WHO. Web. 19 Mar. 2012. <http://www.who.int/mediacentre/factsheets/fs199/en/>.

"Buruli Ulcers." Wikipedia.org. Web. 12 Mar. 2012. <http://en.wikipedia.org/wiki/File:Healed_Buruli_ulcer_lesions.jpg>.

"Evil Ulcers." Undernewskies. Web. 19 Mar. 2012. <http://undernewskies.wordpress.com/2011/05/23/evil-ulcers/>.

Meyers, Wayne M., Walter M. Shelly, and Daniel H. Connor. "Heat Treatment of Mycobacterium Ulcerans Infections Without Surgical Excision." The American Journal of Tropical Medicine and Hygiene. Web. 12 Mar. 2012. <http://www.ajtmh.org.libproxy.lib.unc.edu/content/23/5/924.full.pdf+html>.

"Neglected Infectious Diseases." NCBI. U.S. National Library of Medicine. Web. 19 Mar. 2012. <http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=FIGURE A162. Share of NTD funding by disease, 2008.>.

Walsh, Douglas S., Françoise Portaels, and Wayne Meyers. "Buruli Ulcers: Advances in Understanding Mycobacterium Ulcerans Infection." Clinical Dermatology 29 (2011): 1-8. Print.