Joint Epigenetics & Immunology Symposium “Epigenetics of immunity: mechanisms and therapeutic opportunities” Jonathan Epstein, PhD University of Pennsylvania Ellen Rothenberg, PhD Caltech Cornelis Murre, PhD University of California, San Diego Daniel De Carvalho, PhD University of Toronto Alexander Rudensky, PhD Memorial Sloan Kettering Cancer Center DATE: February 27, 2020 9:00AM -5:30PM LOCATION: RUBENSTEIN AUDITORIUM, SMILOW CENTER FOR TRANSLATIONAL RESEARCH, 3400 CIVIC CENTER BLVD., PHILADELPHIA, PA 19104 Funding for the Symposium has been provided by: The Penn Institute for Immunology, The Penn Epigenetics Institute & the Immunobiology of Normal and Neoplastic Lymphocytes Training Grant Featured Keynotes: There will be a Panel Discussion immediately following with scientific editors from Immunity, Cell, and Nature Immunology…. SPEAKERS Illustration of a functional T cell (background) and an exhausted T cell (foreground). When responding to chronic infection or cancer, T cells become exhausted and lose many of their core functions. This process involves a fundamental “rewiring” of the cellular regulation of gene expression. Thus, exhausted T cells likely represent a distinct cell lineage. See pages 1104, 1160, and 1165.Illustration: Valerie Altounian/Science