Jean-Louis Lanoë Social sciences coordinator Elfe A French Birth Cohort Study
Apr 01, 2015
Jean-Louis LanoëSocial sciences coordinator
Elfe
A French Birth Cohort Study
ELFE” is an acronym for “Étude Longitudinale Française depuis l’Enfance” (French Longitudinal Study since Childhood)
The core methodology of the project is : enrolment and long-term follow-up of a nationally representative cohort of 20,000 children born in 2011
National Partnership
INSTITUT DE VEILLE SANITAIRE
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The scientific objectives and methods of Elfe
The pilot surveys
Education, socialisation and family in the project
- the 'socialisation-education‘ focus group
- the 'school’ focus group
In this communication we present and discuss :
The objectives of the project cover the fields of Social Sciences, Public Health and Environmental Health
Main line: Child Development
Situation at birth (perinatal data) and future health (behavior, nutrition, diseases, accidents…)
Context and interactions: familial, social, economic, physical environment
Physical and cognitive development of the child, educational course, access to work
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Main topics
Social Sciences
• Demographics• Socialization-
Education• Economy-
precariousness
Health- environment
• Chemical exposure• Physical exposure• Environmental
contamination
Cross-disciplinary themes
• Perinatal period • Growth
• Respiratory diseases
• Nutrition
• Psychomotor development • Cancer
Health
• Accidents & trauma• Use of health-care• Infectious diseases
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• School
Methodological aspects (1)
A nationally representative sample of children (births)
All children born in France on 6 specific days of 2011 (April, June, September and December)
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The sample of children to be included in the Elfe cohort :
A two stage random stratified plan with a comprehensive drawing in the second stage.
- first : selection of a stratified sample of maternities (primary units),
- second : inclusion of all births (secondary units) occurring the predetermined days of the survey.
Methodological aspects (2)
542 maternities identified in metropolitan France (after updating for mergers, deletions or creations in the last list available -2008 -).
Sample design was set in order to investigate around 40 500 births :
- an estimated participation of maternities of 90 % and
- 55% of mothers accepting their children to be included in the cohort 20 000 children in the cohort
Methodological aspects (3)
The 542 maternities were classified in 5 strata of equal size (quintiles), constructed on the number of births occurring in the year 2008.
Within each stratum the maternities were sort by :
- region (5 large regions),
- technical level of the maternity (3 levels)
- legal status (2 status).
Methodological aspects (4)
A variable proportion of maternities (100% of the
largest , 25 % of the smallest) was drawn in each stratum (implicit stratification)
total number of births in the sample equals 40 400,
- 342 out 542 maternities were drawn (63%)
- the rate between extreme initial weights is 4.15.
Methodological aspects (5)
Data Collection Plan at different ages (1)
14 ²²² 20 years
6 years
5 years(el. sch.)
3 years
2 years1 year
8 weeks
Birth
Pregnancy
Interview + med files, midwivesBiological samples, midwives
Tel Interview
Tel Interview + m.d questionnaires
Face-to-face Interview +m.d questionnaires
Tel. Interview
Tel interview + school evaluation
Passive longitudinal follow-up from:
School follow-up,DEP, Ministry of education (5 y+)
Environmental data/GIS (InVS)
Medical Data (use of data from Medical System: SNIIRAM)
Insee Demographic Panel (EDP)
Face to face Interview Phys exam+ Psych.tests, Blood Sample (nurse)
At birth in the maternity :
- a 20’ questionnaire + information from medical files
- Biological samples (maternal urines, milk, blood, hair and cord blood)
2 months after birth :
- Phone interview (1hour)
- Daily records on nutrition
- Environmental sensors (dust)
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sData Collection Plan at different ages (2)
Others steps :- Phone interviews at 1 year, 2 years (with records from
physician interview)
- Face to face interview at home at 3 years with biological samples of the child (urines) and environmental sensors (dust)
- Phone interviews at 5 years
- Medical examination at 6 years
Access to other sources :- Those of the Demographic panel (Census data, vital statistics)- Geo-matching with external data on air pollution, quality of water- Family Allowances - Social security system (RNIIAM, PMSI)- Data on children living outside their family (institutions, other families)
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Data Collection Plan at different ages (3)
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Pilots studies
Test acceptability, feasibility and relevance of the national survey
Two waves : children born in all maternities of : Bourgogne and Picardie on 2, 3 and 4 April 2007 and Isère, Loire, Savoie, Ardèche et Seine-Saint-Denis les 1, 2, 3 et 4 october 2007
74 maternity units surveyed : 900 expected births
Tracking in the pilot survey (1)
In the maternity unit- 915 births but 834 with inclusion criteria
- 447 women accepted the study and have correct adress
- Sucess rate = 54%
Causes of failure- 50% refusal (10% from the father)
- 22% due to language difficulties
- 12% due to failure to make contact (mother leaves maternity unit)
- 9% due to child health status
- 3% due to mother health status
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Biological samples collection (pilot)
Tracking in the pilot survey (2)
At 2 months : interview (home face to face interview)
- 447 with corrected adress sent to Insee
- 384 women were interviewed (and 352 fathers)
- Attrition = 6,9%
- 86% mothers and 79% fathers accepted
- 7% mothers and 11% fathers refused- 5% of mothers and 6% of fathers could not be contacted
by phone
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Tracking in the pilot survey (3)
At 1 year
- 419 with corrected adress sent to pollster
- 343 women were interviewed- Attrition = 6,7 %
At 2 years
- 390 with corrected adress sent to pollster
- 318 women were interviewed
- Attrition = 7 %
- 3 years survey is ongoing
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Education, socialisation and family in the project (1)
The focus group ‘Socialization-education’ main topics :
Family relations : rites, relation parent-child
Division of domestic labor
Worldview of parents : religion, politics, justice, relationship to the social environment, perception of social order, religious education
Caring for the child : childcare for children, school- family relationship
Learning : the first links, educational practices motor development, language, behavior, motor fonction, child learning
Children’s corner : fun activities, relationship to the body
Education, socialisation and family in the project (2)
The focus group ‘Socialization-education’ : Forthcoming projects
- Juvenile delinquency in college : long-term project (social morality, embedding socio geographic determinants)
- The accommodation of the child during her first year: short-term project
- The child and his family: short-term project (siblings and extended family in the context of blended families)
- Separation of parents and economic well-being of children: medium and long term projects:
- Child and family, family relationships over time : long-term project
Education, socialisation and family in the project (3)
The focus group ‘Socialization-education’ : Forthcoming projects
-Living conditions, family practices and school achievement in CP: medium-term project (integrate childcare and cultural practices)
- Production of identities and gender inequality
- Working mothers and family arrangements (work, income, childcare, marital)
Education, socialisation and family in the project (4)
The focus group ‘School’ :
- responsible for the construction of protocols on the course and school performance in link or not with the Ministry of Education.
- A mixed group "Education-socialization" and "development".
- Investigation and evaluation might be done in the year 2016-2017 by the Department of Education on the older Children in Kindergarten
- problem would be to find the ‘Elfe children’ among those who would be evaluated (20 000 /800 000) + limited choice concerning the types of questionnaires
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Education, socialisation and family in the project (4)
The focus group ‘School’ :
- If no evaluation by the department of education : need to identify schools where children are educate
- Tests would be passed in two sequences of 20 minutes each to cover areas such as :
- the mastery of language (oral, written)
- numerical skills
- reasoning, cognitive activities
- fine motor skills, physical activities
- school behavior, school readiness, ability to learn (questionnaire for teachers)
Jean-Louis Lanoë
Thank you for your attention
Gracias por su atención
Legal issues in France (1)
• The collection of a large amount of data on the same individual requires a strict policy for protecting the privacy of these data
• Each set of data will be stored separately, with a specific identifier
• All databases will be strictly anonymous. A third party will keep the links between the name of a participant and his identifiers in the data files. The data files and the identification file will be kept by separate institutions
• Access to data will be authorized by a special Committee, and under conditions preventing all possibilities of ‘indirect identification’
• The technical conditions of this access are not yet decided (local or distant access to a unique server...)
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Legal issues in France (2)
• Specific to Elfe controls: The Scientific Committee and The Group on ethics
• National controls:
- CNIS (National Council for Statistical Information)
- CNIL (National Data Protection Authority)
- CCTIRS (National Committee for the Treatment of Data in Research on Health)
- CPP (Local Committee for the protection of individuals in case of biological samples)
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Nathalia Baltzinger
Cohort maintenance on the pilot study
Cohort maintenance
Main objectives
Tested strategy
First results
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Main objectives
Minimise sample attrition due to failure to locate families
Encourage members to stay in the cohort
To reach these objectives, the ideas were :
- to keep in touch with the families in-between waves
- to be quartely (or four times a year) present
- to commit the members by giving them information about the study
- but to avoid being too intrusive
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Strategy tested on the pilot (1)
A cohort maintenance’s strategy mainly based on :
Informative documents
Greeting card policy
Gift policy
Email surveys
Pilot family group
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Strategy tested on the pilot (2)
Informative documents (1/4)• Printed documents
• Leaflet• This document is given at the
hospital at the end of the first interview
• It shortly presents the study (main objectives, schedule, etc.)
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Strategy tested on the pilot (3)
Informative documents (2/4)
• Printed documents
• Elfe Infos• A newsletter sent home twice a
year• Its purposes :
• explaining the study• presenting the major
results• reminding the families
of the next interviews37
Strategy tested on the pilot (4)
Informative documents (3/4)
• Printed documents
• Mails or letters announcing interviews
Before each wave, a letter is sent
home with the major details of the interview
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Strategy tested on the pilot (5)Informative documents (4/4)
What about our web policy ?
For the pilot study : a rather « shy » web policy• December 2009 : 65 % of french people were
Internet users
For the national study : a specific web policy • In the next few years we will develop an internet
policy with specific messages and blogs
- for the families
- for the children (when they will be able to use Internet)
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Strategy tested on the pilot (6)
Greeting card policy (1/3)
• Birthday cards
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Strategy tested on the pilot (7)
Greeting card policy (2/3)
• New year’s cards (printed and electronic)
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Strategy tested on the pilot (8)
Greeting card policy (3/3)
• Postage-paid cards for families to give us their new address
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Strategy tested on the pilot (9)
Gift policy• As most studies in France, Elfe is a non-paid study.
No financial incentive can be given.• Our purpose was just to give families something to
thank them for their participation• Our problem was to find something :
• related to study• neutral• useful• nice looking• not bad for the children’s health• lasting
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Strategy tested on the pilot (10)
Gift policy
What we tested on the pilot cohort :• 2 months survey : a magnet branded with our
study’s logo• 1 year survey : an embroidered bib• 2 year survey : a pop up flap book• 3 year survey : a smaller cheaper book
What is planned for the national cohort :• Giving the baby a small organic cotton blanket
which hopfully will become his or her « blankie »
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Strategy tested on the pilot (11)
@mail survey• check the adresses (e-mail and mail)• check the families’ understanding of Elfe• check their opinion on our methodology• engage the respondent sufficiently so that he
or she wants to stay in our cohort
Main results• 167 mothers ad 130 fathers received the
survey • 78 mothers and 36 fathers answered• 74 % (mothers and fathers) declared that they
had not understood Elfe's objectives45
Strategy tested on the pilot (11)
Pilot family group
• check their opinion on :• our methodology• our questions• our communication policy
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First results
It turned out that :
families don’t like to be too « sought after »
two thirds of the families who quit the study said it was because the survey was too much « time consuming »
the postage-paid card was returned by only 11 families (VS 391 sent)
families really appreciated our gifts, the greeting cards and the newsletter we sent them
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Conclusion and questions
This policy will help us for the cohort maintenance and the creation of a membership feeling
Some events or actions we did not test (meetings, blog or Internet forum, etc) will certainly be useful
We are very interested in your ideas and suggestions, so please feel free to share them with us
Is it possible to get in touch with people in charge of communication in your study ?
If you have any questions, Stéphanie and I will be pleased to answer them.
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La collecte biologique dans ELFE – Etude nationale
Présentation EFS – 02/04/2010 Page 49
Concerne:• 10 000 couples mère-enfant(s)
• Certaines maternités Taille +++ : > 500 naissances/an
Proximité géographique centre EFS (partenariat)
Se déroule:• En 2 étapes:
Accouchement (J0)
En suite de couche (J1-J3)
Organisation générale de la collecte nationale
Page 50Présentation EFS – 02/04/2010
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Some questions to answer…
In the field of Health • What are the exposure levels to physical (noise…),
chemical (tobacco smoke, pesticides…) and biological (allergens…) factors during pregnancy and early childhood and what are their long term consequences?
• What are the early origins of obesity?
In the field of Social Sciences• What are the effects of Poverty and Social Policies on
families and children?• What are the consequences of Family composition
(blended families, single parent families…), events (divorces and second marriages…) and constraints (employment of the mother, long distance commuting…) on children development and life?
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…
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Jean-Louis Lanoë, 1 des 4 coordinateurs scientifiques du projet Elfe
- Deux médecins, chacun à mi temps, se partagent la coordination scientifique du domaine santé :
• Corinne Bois, médecin de PMI dans les Hauts de Seine, et
• Marie Noëlle Dufourg, pédiatre, à l’hôpital Antoine Béclère à Clamart.
- Ilias Kavouras, spécialiste de la chimie de l’environnement nous à rejoint il y a un peu plus de 6 mois depuis l’université de la Vegas. Coordination du domaine ‘environnement’ ; il remplace Stéphanie Van Dentorren, rappelée à l’Institut de Veille Sanitaire
…
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Enfin moi même, économiste, chercheur à l’Inserm
- Intégration dans l’équipe il y a maintenant presque deux ans
- coordination sciences sociales du projet après Claudine Pirus.
…
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Le travail de coordination scientifique dans le projet Elfe.
-faire émerger des programmes de recherche cohérents sur les diverses thématiques propres à chaque domaine.
- nécessité en amont d’une large concertation avec les équipes de recherche
- négociations et des arbitrages ‘intra thèmes’ et ‘inter domaines’ sur la place des uns et des autres
Une tâche pas toujours facile !!
à permettre que les programmes de recherche puissent trouver concrètement la ‘substance’ dont ils ont besoin, donc :
- que les enquêtes soient possibles,
- qu’elles se réalisent dans de bonnes conditions et
- que les données collectées soient de qualité.
En ces matières ce sont les services de l’Ined qui jouent un rôle majeur par leur expertise et leur compétence.
Le travail de coordination scientifique consiste aussi
- service des enquêtes pour tout ce qui concerne la finalisation des questionnaires et les relations avec les prestataires à l’occasion des enquêtes pilotes,
- service de méthodologie statistique (échantillonnage, pondérations),
- service juridique pour tout ce qui relève des appels d’offres à prestataires et de la constitution des dossiers pour la CNIL, Le CCTIRS
- service des ressources humaines pour principalement pour les embauches liées au projet.