January 27, 2009 4 th BVDV Symposium –BVDV Variability: Impact on Virulence, Host Range, and Control Bovine Viral Diarrhea Virus (BVDV) Research Needs.

January 27, 20094th BVDV Symposium –

BVDV Variability: Impact on Virulence, Host Range,

and Control

Bovine Viral Diarrhea Virus (BVDV) Research Needs and Coordinating Efforts of NCBA, AABP, AVC, and

USAHA

BVDV Research Priorities: Input NCBA BVD Research Subcommittee

2008NCBA BVD Working Group 2008Academy of Veterinary Consultants:

BVDV committeeAABP BVDV committee2008 USAHA Infectious Diseases of

Cattle Committee

Priority ItemKnowledge GapApproachDeliverable

BVDV Research Priorities1. Assessment of the Economic Impact of BVDV

in Beef Production Operations2. Design and Evaluation of Surveillance/Control

Programs3. Surveillance, Identification, and

Determination of Significance of Emerging BVDV Subtypes

4. Development and Critical Evaluation of Diagnostic Tests

5. Critical Evaluation of Current Vaccines6. Development of Innovative New BVDV

Vaccines7. Investigate the Pathogenesis of BVDV in

Cattle Based on Disease Predisposition and Genetics

BVDV Research PrioritiesAssessment of Economic Impact of

BVD in Beef Production Operations General economic impact of BVDTransmission dynamics of PI

(Persistently Infected) and TI (Transiently Infected) BVD cattle in production enterprises in relation to economic cost

Morbidity and mortality rate of TI and PI calves in relation to economic cost

Design and Evaluation of Surveillance Programs

Surveillance strategies for early detection of PI BVDV incursion in BVDV negative beef breeding herds and support for herd disease freedom claims

Testing strategies at the ranch, dairy, auction market or feedyard to economically detect positive individuals and herds and to control herd introduction risk

Management strategies for biosecurity and biocontainment to control impact of PI cattle

Role of wildlife as reservoir of exposure and infection for cattle

Surveillance, Identification, and Determination of Significance of

Emerging BVDV Subtypes

Detection and confirmation of new BVDV subtypes in the U.S.

Determine if differences among BVDV subtypes affect diagnostic and vaccine performance.

Development and Critical Evaluation of Diagnostic

Tests

Validation of diagnostic tests available in the U.S.

Innovative test development

Critical Evaluation of Current Vaccines

Fetal protection challenge studies for all USDA licensed vaccines

Effective models for acute challenge for the postnatal susceptible calf

Duration of immunity after BVDV vaccination

Development of Innovative New BVDV Vaccines

Novel vaccinesMarker vaccinesAdjuvants

Investigate the Pathogenesis of BVDV in Cattle Based on Disease

Predisposition and Genetics

Genetics for infectious disease resistance/susceptibility relating to BVDV

Critical Issues Facing BVDV Programs and Various Groups Definition and agreement on goals of

control and eradicationAdequate funding at federal- state levels

Private and corporate , producer organizations

Collaborative research teams Unified voice on control programs to the

producersNumerous groups already involved

Potential of a national committee with range of participants