IV FLORENCE INTERNATIONAL SYMPOSIUM CARDIO 16_2019_Programma_Firenze UV(1).… · next generation sequencing gene testing, innovative pharmacological approaches and the subcutaneous

On advances in IV FLORENCE INTERNATIONAL SYMPOSIUM

MYOPATHIESCARDIO

2nd–3rd April2020

FLORENCEItaly

VENUE: PALAZZO DEI CONGRESSI – AUDITORIUM, FLORENCE

C O - O R G A N I Z E D B Y

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FROM THE SYMPOSIUM DIRECTORS

Dear colleagues,

It is a great pleasure to invite you to the “IV Florence International Symposium on Advances in Cardiomyopathies”, to be held in Florence on the 2nd and 3rd of April 2020. As in the previous editions held in 2008, 2012 and 2015, the course is designed to constantly promote close interaction between basic science and clinical practice, in an attempt to address the topic in a truly global fashion. Novel options such as next generation sequencing gene testing, innovative pharmacological approaches and the subcutaneous ICD will be discussed. It is hoped that the broad range of topics will attract the interest of a wide audience, including physicians, clinical researchers, cardiologists, pathologists, basic scientists, and young investigators. A wide and open discussion among all the participants is welcome.We hope that the Symposium will be extremely productive, providing with an opportunity to improve our understanding of this challenging area of expertise and to stimulate further research into the field.

We look forward to welcoming you in Florence next April.

Arrivederci a Firenze !!

Iacopo OlivottoFranco Cecchi

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SCIENTIFIC COMMITTEE:

Franco Cecchi Associate Professor of Cardiovascular Diseases,

University of Florence, Florence, IT

Department of Cardiovascular, Neural and Metabolic Sciences, IRCCS,

Istituto Auxologico Italiano, S.Luca Hospital, Milan, IT

Iacopo OlivottoAssociate Professor of Cardiovascular Diseases,

University of Florence, Cardiomyopathy Unit, Careggi University Hospital,

Florence, IT

CO-ORGANIZED BY:

FONDAZIONE INTERNAZIONALE MENARINICentro Direzionale Milanofiori

20089 Rozzano (Milan, Italy) Edificio L – Strada 6

Phone: +39 02 55308110 Fax: +39 02 55305739

E-mail: [email protected] Website:\\www.fondazione-menarini.it

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PRELIMINARY PROGRAMME

SESSION II - A NEW ERA FOR CARDIOMYOPATHIES

Chairmen:P. G. Camici (Milan, IT)C. Poggesi (Florence, IT)

11.15 a.m.11.35 a.m.

R. Bonow (Chicago USA)Evolving burden of Cardiomyopathies worldwide

11.35 a.m.11.55 a.m.

M. Pieroni (Arezzo, IT)A role for inflammation in genetic Cardiomyopathies?

11.55 a.m.12.15 p.m.

L. Carrier (Hamburg DE)Gene therapy 2020 update

12.15 p.m.12.35 p.m.

P. Elliott (London, UK)Drug development and trial design

12.35 p.m.12.55 p.m.

Discussion

12.55 p.m.02.00 p.m.

Lunch

DAY 1 - April 2nd 2020 - Morning08.30 a.m.09.00 a.m.

Registration

09.00 a.m.09.15 a.m.

Official opening: welcome by Scientific Directors F. Cecchi (Florence, IT), N. Marchionni (Florence, IT), I. Olivotto (Florence, IT)

SESSION I - GENOTYPES AND PHENOTYPES

Chairmen:E. Arbustini (Pavia, IT)J. Ware (London, UK)

09.15 a.m.09.35 a.m.

L. Montserrat (La Coruña, ES)A decade of next generation sequencing: challenges and opportunities

09.35 a.m.09.55 a.m.

F. Mazzarotto (Florence, IT)Distinguishing the true from the untrue: evaluating gene-disease associations

09.55 a.m.10.15 a.m.

J. Ware (London, UK)Crossing the boundaries of Mendelian disease: what’s on the other side

10.15 a.m.10.35 a.m.

C. Basso (Padua, IT)The pathologist in transition from genetics to phenotype

10.35 a.m.10.55 a.m.

Discussion

10.55 a.m.11.15 a.m.

Coffee Break

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SESSION IV - HYPERTROPHIC CARDIOMYOPATHY 2

Chairmen:M. Emdin (Pisa, IT)S. Favilli (Florence, IT)

04.00 p.m.04.20 p.m.

F. Cecchi (Florence, IT)The complex HCM patients: a clinical checklist

04.20 p.m.04.40 p.m.

I. Olivotto (Florence, IT)Risk stratification in adults and children

04.40 p.m.05.00 p.m.

S. M. Day (Philadelphia, USA)Big data and role of international registries

05.00 p.m.05.20 p.m.

L. Crotti (Milan, IT)Exploring the overlap between Cardiomyopathies and channellopathies

05.20 p.m.05.40 p.m.

Discussion

05.40 p.m.06.00 p.m.

R. Bonow (Chicago, USA)F. Cecchi (Florence, IT)Honor thy mentor: an interview with Barry J. Maron

06.00 p.m. Closing of the day

SESSION III - HYPERTROPHIC CARDIOMYOPATHY 1

Chairmen:A. Anastasakis (Athens, GR)G. Limongelli (Naples, IT)

02.00 p.m.02.20 p.m.

L. Salberg (New York, USA)What patients want

02.20 p.m.02.40 p.m.

R. Coppini (Florence, IT)Disopyramide: a translational reappraisal

02.40 p.m.03.00 p.m.

M. S. Maron (Boston, USA)Invasive management of LV obstruction

03.00 p.m.03.20 p.m.

S. Heitner (Portland, USA)Experience with direct myosin modulators

03.20 p.m.03.40 p.m.

Discussion

03.40 p.m.04.00 p.m.

Coffee Break

DAY 1 - April 2nd 2020 - Afternoon

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SESSION V - TREATING THE END STAGE CARDIOMYOPATHY PATIENT

Chairmen:M. G. Bongiorni (Pisa, IT)C. Di Mario (Florence, IT)

09.00 a.m.09.20 a.m.

G. Sinagra (Trieste, IT)Clinical spectrum of advanced heart failure in cardiomyopathies

09.20 a.m.09.40 a.m.

M. Frigerio (Milan, IT)Heart transplant in genetic diseases

09.40 a.m.10.00 a.m.

P. Della Bella (Milan, IT)Role of the electrophysiologist: Ventricular ablation versus implantation

10.00 a.m.10.20 a.m.

M. Yacoub (Aswan, EG)From LV assist device to regeneration

10.20 a.m.10.40 a.m.

Discussion

10.40 a.m.11.00 a.m.

Coffee Break

DAY 2 - April 3rd 2020 - Morning08.30 a.m.09.00 a.m.

Registration

SESSION VI - RARE CARDIOMYOPATHIES

Chairmen:E. Biagini (Bologna, IT)G. Limongelli (Naples, IT)

11.00 a.m.11.20 a.m.

E. Arbustini (Pavia, IT)The paradigm of Lamin A/C disease

11.20 a.m.11.40 a.m.

D. Corrado (Padua, IT)Risk stratification and management of left dominant arrhythmogenic Cardiomyopathy

11.40 a.m.12.00 p.m.

C. Rapezzi (Bologna, IT)TTR amyloidosis : which candidates for novel treatments

12.00 p.m.12.20 p.m.

M. Emdin (Pisa, IT)Novel approaches to AL amyloidosis

12.20 p.m.12.40 p.m.

Discussion

12.40 p.m.01.00 p.m.

Two best abstracts award and presentation

01.00 p.m.02.00 p.m.

Lunch

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SESSION VII - NEW CONCEPTS IN THE CLINICAL ARENA

Chairmen:G. Castelli (Florence, IT)E. Cerbai (Florence, IT)

02.00 p.m.02.20 p.m.

J. Moon (London, UK)Advances in CMR: a never ending story

02.20 p.m.02.40 p.m.

S. M. Day (Philadelphia, USA))Lifestyle issues: tailored exercise prescription in HCM patients

02.40 p.m.03.00 p.m.

N. Marchionni (Florence, IT)Ageing of the heart: a Cardiomyopathy?

03.00 p.m.03.20 p.m.

N. Maurizi (Florence, IT)Screening for cardiac diseases in the developing world

03.20 p.m.03.40 p.m.

Discussion

03.40 p.m.04.00 p.m.

Coffee break

SESSION VIII - THE CHALLENGE OF ATHLETES AND SPORTS RELATED DEATH

Chairmen:G. D. Aquaro (Pisa, IT)P. Elliott (London, UK)

04.20 p.m.04.40 p.m.

P. Zeppilli (Roma, IT)How to interpret the ugly ECGs

04.40 p.m.05.00 p.m.

C. Semsarian (Sydney, AUS)Genetic causes of unexplained sudden death

05.00 p.m.05.20 p.m.

M. Lombardi (Milan, IT)How to use imaging wisely in sports medicine

05.20 p.m.05.40 p.m.

Discussion

05.40 p.m.06.00 p.m.

Conclusions and final remarks

06.00 p.m. Closing of the Symposium

DAY 2 - April 3rd 2020 - Afternoon

04.00 p.m.04.20 p.m.

LECTUREB. J. Maron (Minneapolis, USA)Understanding and treating HCM: state-of-the-art after 50 years of clinical investigation

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FACULTY LIST

Aris Anastasakis (Athens, GR)

Giovanni Donato Aquaro (Pisa, IT)

Eloisa Arbustini (Pavia, IT)

Cristina Basso (Padua, IT)

Elena Biagini (Bologna, IT)

Maria Grazia Bongiorni (Pisa, IT)

Robert Bonow (Chicago, USA)

Paolo Guido Camici (Milan, IT)

Lucie Carrier (Hamburg, DE)

Gabriele Castelli (Florence, IT)

Franco Cecchi (Florence, IT)

Elisabetta Cerbai (Florence, IT)

Raffaele Coppini (Florence, IT)

Domenico Corrado (Padua, IT)

Lia Crotti (Milan, IT)

Sharlene Mary Day (Philadelphia, USA)

Paolo Della Bella (Milan, IT)

Carlo Di Mario (Florence, IT)

Perry Elliott (London, UK)

Michele Emdin (Pisa, IT)

Silvia Favilli (Florence, IT)

Maria Frigerio (Milan, IT)

Stephen Heitner (Portland, USA)

Giuseppe Limongelli (Naples, IT)

Massimo Lombardi (Milan, IT)

Niccolò Marchionni (Florence, IT)

Barry J. Maron (Minneapolis, USA)

Martin S. Maron (Boston, USA)

Niccolò Maurizi (Florence, IT)

Francesco Mazzarotto (Florence, IT)

Lorenzo Monserrat (La Coruña, ES)

James Moon (London, UK)

Iacopo Olivotto (Florence, IT)

Maurizio Pieroni (Arezzo, IT)

Corrado Poggesi (Florence, IT)

Claudio Rapezzi (Bologna, IT)

Lisa Salberg (New York, USA)

Christopher Semsarian (Sydney, AUS)

Gianfranco Sinagra (Trieste, IT)

James Ware (London, UK)

Magdi Yacoub (Aswan, EG)

Paolo Zeppilli (Roma, IT)

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GENERAL INFORMATION

CONGRESS VENUEFirenze Fiera, Palazzo dei Congressi – AuditoriumPiazza Adua, 1 - 50123 Florence, ITwww.firenzefiera.it

An exclusive area in one of the most beautiful places in the world - this is what theFirenze Fiera Congress & Exhibition Center offers to those who organise exhibitionsand congresses, as well as to the event attendees. The over 100,000 square metresavailable inside our center are actually located in the heart of Florence, between thecity historic centre and the boulevards, major traffic arteries built over the lay-out ofthe ancient city walls.

ARRIVING BY PLANEThe international airport of Firenze Peretola ‘Amerigo Vespucci’, is located in the north-west suburban area of Florence. There are many airlines arriving there and connecting the city to some of the most important European airports. The airport is only 6 km from the city cen-tre, which can be easily reached by taxi or with the Tramvia T2 Line from Peretola Airport to Firenze Santa Maria Novella train station(around 15 minutes).www.aeroporto.firenze.itwww.gestramvia.com/t2-vespucci

ARRIVING BY TRAINThe main central railway station of Santa Maria Novella (one of the most important railway junctions as well as an interchange point of Florence public transportation) is located just a few steps (2 minutes walk) from the main entrance of the congress exhibition area and from the reception of Firenze Fiera.www.trenitalia.com

ARRIVING BY CARFlorence is well connected to the main Italian cities through an efficient motorway network, whi-ch allows an easy access to the city centre, where the congress and exhibition centre is located.It is possible to park at the paying underground car park at Santa Maria Novella railway station.

GENERAL INFORMATION

SECRETARIAT DURING THE MEETING The Secretariat will be open at the following times: Thursday, April 2nd, from to 08:00 a.m. to 6:00 p.m. Friday, April 3rd, from to 08:00 a.m. to 6:00 p.m.

OFFICIAL LANGUAGE The official language of the Meeting will be English. Simultaneous translation will not be provided.

REGISTRATION The Meeting is free to attend. For more information and to register please visit the following website: www.en.fondazione-menarini.it and App Fondazione Menarini.

TECHNICAL FACILITIES Facilities will be available for computer presentations and overhead projections. A Slide Centre with PCs (Windows and Macintosh operating systems) will be available for Speakers to preview and finalize their presentations. Speakers are kindly requested to submit their presentations to the Slide Centre technicians at least one hour before their talks.

SLIDE CENTRE OPENING HOURS Thursday, April 2nd, from to 08:00 a.m. to 6:00 p.m. Friday, April 3rd, from to 08:00 a.m. to 6:00 p.m.

LUNCHES AND COFFEE BREAKS Lunches and coffee breaks will be served in the Meeting area, free of charge

Fondazione Internazionale Menarini Symposium n: 445

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NOTES

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NOTES

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NOTES

2nd–3rd April2020

FLORENCEItaly

C O - O R G A N I Z E D B Y

FONDAZIONE INTERNAZIONALE MENARINISYMPOSIA: N. 445