ISSX Newsletter | Issue 3, 2013

ISSX President’s Message: See You in Toronto!

Volume 32 Issue 3, 2013

I’m keeping the President’s message for the newsletter short and sweet for this issue. Why you ask? Simply because I’m going to see you in Toronto in just a few weeks! ISSX has a great tradition of organizing an international meeting every three years with regional meetings in North America, Europe, and Asia-Pacific in between. ISSX leadership

felt that Toronto, Canada was a great location for the 10th International Meeting because 1) our 7th International Meeting in Vancouver, Canada in 2004 was the most attended ISSX meeting to date; 2) there is easy access to Toronto for international travelers; 3) our headquarters hotel, the Westin Harbour Castle, is a great hotel and conference center with great amenities; and 4) the superb support by Meeting Organizing Committee (MOC) Chair Denis Grant, at the University of Toronto along with his entire committee. By now you have reviewed the fantastic program Denis and his MOC created for this meeting. I hope you agree that the quality of the science that will be presented is reason enough to attend. But if it isn’t, our Wednesday, October 2 party at the Hockey Hall of Fame will probably be enough to

tip you over the edge. There are many things you can do to support ISSX, but your active participation in the meetings has the most impact. So if you haven’t yet registered please reconsider because I would love to see you in Toronto!

Bill J. SmithISSX President

By Bill J. Smith, ISSX President

Read all about the 10th International ISSX Meeting on page 3

ISSX President’s Message

Book Review: Natural Products Isolation

Upcoming Meetings

10th International ISSX Meeting Announcement

New Members

Nominate a Colleague for the 5th Asia Pacific ISSX Meeting Awards

IN THIS ISSUE1 2 10

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Toronto, Ontario, Canada • September 29 - October 3, 2013

International

NATURAL PRODUCTS ISOLATIONMethods and ProtocolsEditors: Satyajit D. Sarker and Lutfun NaharHumana Press, Springer-Verlag GmbH, Germany.564pp, ISBN 978-1-61779-623-4, 2012

The wealth of natural products available from our surroundings is phenomenal and, from a numerical standpoint, we have only just begun to rummage through this vast resource. The exploitation of natural products as materia medica for treatment of various disorders probably dates back to man’s origins and has been improved upon over the ensuing centuries, albeit with countless false claims made and countless false avenues pursued. Within our modern scientific age there has been a revival of interest in natural products with attention paid to their biological activity and its refinement by chemical modification. As declared in the introductory chapter, such natural products offer, “…templates for the development of novel scaffolds of drugs.” (page 1). Unfortunately, the separation of these desired products, as a starting point, from the biochemical matrices presented by living tissues is a major and unenviable task for the researcher.

As the editors state in their preface, “Techniques for extraction and isolation of natural products… […]…have evolved over the years, and

particularly over the last couple of decades…” (page vii) and that this volume is designed to provide, “…a number of ‘hands on’ approaches and ‘step-by-step’ protocols to help natural products researchers follow and implement these protocols in their own research” (page vii). As may be expected, this book comes under the area entitled, “Springer Protocols,” being part of the “Methods in Molecular Biology” series (No. 864), and is now in its third edition. This impression has been carefully revised and contains twenty chapters, some of which are new to this edition. Most other chapters have been expanded, restructured and modernized to enhance their appeal and helpfulness in applying available methodologies and techniques to those involved in the field of natural product extraction.

After an opening commentary and an essay on initial bulk extraction, the following chapters discuss various extraction methods including, accelerated solvent extraction, microwave-assisted extraction, planar chromatography, low-pressure column chromatography, ion-exchange methods, countercurrent chromatography, high performance liquid chromatography, preparative gas chromatography, and several hyphenated techniques. This section is followed by articles addressing plant secondary metabolites, marine products, microbial products, saponins

and phenolic compounds, with the tome culminating in discussions of scaling up natural product isolation, their follow-up and their role in modern drug discovery programmes.

The 31 authors involved have produced some interesting and informative works. The layout is easy to read with many figures and references enhancing the volume. Good quality paper, firm binding and overall solid construction ensure that this book will remain functional for many years. This is strongly recommended for those involved in this area of natural product research, and that probably means most of us from time to time.

Reviewed bySteve MitchellFaculty of MedicineImperial College LondonLondon SW7 2AZ, UK

Book ordering information:Humana PressSpringer-Verlag GmbHTiergartenstrasse 1769121 HeidelbergGermanyWeb: http://www.springer.comFax: +49 (0)6221-487-8366

Book Review

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UPCOMING MEETINGS

10th International ISSX Meeting

The Westin Harbour Castle HotelToronto, Ontario, Canada

September 29–October 3, 2013MOC Chair: Denis Grant

5th Asia Pacific ISSX Meeting

Tianjin, ChinaMay 9–12, 2014

MOC Chairs: Zhuohan Hu, John O. Miners

29th JSSX and 19th North American ISSX Meeting

Hilton San FranciscoSan Francisco, California, USA

October 19–23, 2014MOC Chairs:

Tetsuya Terasaki, Eric Johnson

20th North American ISSX Meeting

Hilton Orlando Bonnet CreekOrlando, Florida, USAOctober 18–22, 2015

MOC Chairs: Hartmut Derendorf, Stephen Schmidt

Announcement Reminder

Why You Should Attend the 10th International ISSX Meeting

This meeting will bring together individuals who are actively working on drug/ xenobiotic research in diverse fields including basic and clinical pharmacology and therapeutics, toxicology, oncology, endocrinology, physiology, biochemistry, medicinal chemistry, molecular and structural biology, and genetics. If you work in the fields of toxicology, pharmacy, or molecular biology or if you study xenobiotics, you can’t afford to miss the 10th International ISSX Meeting.

• Learn the latest information in this dynamic and specialized field through our Short Course program, a variety of timely scientific symposia, and topical keynote and plenary sessions.

• Expand your knowledge of drug metabolism and disposition by learning from our outstanding faculty assembled from leading experts in the field worldwide.

• Scientific meetings organized by ISSX offer numerous outstanding scientific sessions and many opportunities for substantive conversations with scientists worldwide. Our exhibitors will be showcasing the products and services important to you in your research and development.

• Enjoy informal social interactions with fellow researchers, and also enjoy exploring Toronto - Canada’s largest city, its financial center, and the capital of the province of Ontario. In Toronto you will find a vibrant, safe and walkable downtown core, excellent transit access to many cozy neighborhoods, stunning traditional and modern architecture, world-class museums and galleries, an abundance of nightlife, and more than 7,000 restaurants of every price range and ethnic flavor imaginable!

Meeting Organizing Committee and International Scientific Advisory Board

Denis Grant (Meeting Chair), University of Toronto, Toronto, ON, Canada

Stelvio Bandiera, University of British Columbia, Vancouver, BC, Canada

Jack Bend, University of Western Ontario, London, ON, Canada

Chantal Guillemette, Laval University, Quebec, QC, Canada

Malle Jurima-Romet, Celerion, Montreal, QC, Canada

David K.H. Lee, NoAb Biodiscoveries, Mississauga, ON, Canada

Tom Massey, Queen’s University, Kingston, ON, Canada

Eddie Morgan, Emory University, Atlanta, GA, USA

Sandy Pang, University of Toronto, Toronto, ON, Canada

Allan Rettie (SAC Member), University of Washington, Seattle, WA, USA

David Riddick, University of Toronto, Toronto, ON, Canada

Nathalie Rioux, Boehringer Ingelheim (Canada), Ltd., Laval, QC, Canada

Rachel Tyndale, University of Toronto, Toronto, ON, Canada

Peter Wells, University of Toronto, Toronto, ON, Canada

A complete listing of the International Scientific Advisory Board (ISAB) is available online at www.issx.org/international2013/isab

Continued on next page

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Toronto, Ontario, Canada • September 29 - October 3, 2013

International

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Scientific Program (Schedule is subject to change)

Sunday, September 29, 2013

Concurrent Morning Short Courses | 09:00 – 12:00

Short Course I: Metabolomic Profiling as a Tool for Identifying Novel Drug-Target Interactions | Harbour Ballroom C

Chair: David Wishart, University of Alberta, Edmonton, AB, Canada

Short Course II: Model Systems and Methods for Assessing Uptake and Efflux of Small Molecules | Harbour Ballroom AB

Chair: Reina Bendayan, University of Toronto, Toronto, ON, Canada

Concurrent Afternoon Short Courses | 13:30 – 16:30

Short Course III: Strategies and Techniques for Predicting Human Drug Metabolism and Drug-Drug Interactions | Harbour Ballroom AB

Chairs: Uwe Fuhr, Uniklinik Koln, Koln, Germany; Olavi Pelkonen, University of Oulu, Oulu, Finland

Short Course IV: Application of Novel Mass Spectrometric Methods to Drug Metabolism and Pharmacokinetics Studies | Harbour Ballroom C

Chair: Ragu Ramanathan, QPS, Newark, DE, USA

Keynote Lecture | 18:45 – 19:30

Systems Pharmacology – Systems Biology Meets Drug Discovery & Development | Frontenac

Doug Lauffenburger, Massachusetts Institute of Technology, Cambridge, MA, USA

Monday, September 30, 2013

Plenary Session 1 | 09:00 – 10:30

Plenary Session 1: Drug-Metabolizing Enzymes as Potential Therapeutic Targets | Frontenac

Chair: Paul Hollenberg, University of Michigan, Department of Pharmacy, Ann Arbor, MI, USA

2013 ISSX Awards Presentation | 11:00 – 12:00

Frontenac | ISSX Awards2013 R.T. Williams Distinguished Scientific Achievement Award Presentation and Lecture

Yuichi Sugiyama, Ph.D.

2013 Frederick J. Di Carlo Distinguished Service Award Presentation to Robert P. Hanzlik, Ph.D.

Parallel Sessions 1 and 2 | 13:30 – 15:30

Parallel Session 1: Nuclear Receptors as Regulators of Drug Metabolism and as Therapeutic Targets | Frontenac

Co-Chairs: Ulrich Zanger, Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany; Hongbing Wang, University of Maryland, School of Pharmacy, Department of Pharmaceutical Science, Baltimore, MD, USA

Parallel Session 2: Pharmacogenomics and Personalized Medicine: Progress in Clinical Implementation | Harbour Ballroom

Chair: Rachel Tyndale, University of Toronto, Toronto, ON, Canada


Parallel Session 3: Regulation of Drug Transporter Expression and Function | Frontenac

Chair: Micheline Piquette-Miller, University of Toronto, Toronto, ON, Canada

Parallel Session 4: Application of Structural

Biology to the Prediction of Drug Response, Metabolism and Toxicity | Harbour Ballroom

Chair: James Halpert, University of California, San Diego, CA, USA

Tuesday, October 1, 2013


Plenary Session 2: Utility of Genetic and Epigenetic Technologies in Drug Development and Safety Assessment | Frontenac

Chair: Ann Daly, Newcastle University, Institute of Cellular Medicine, Newcastle Upon Tyne, UK


Parallel Session 5: Metabolism, Pharmacokinetics and Interactions of Traditional Medicines and Natural Products | Frontenac

Co-Chairs: Chuan Li, SIMM, Shanghai, China; Ge Lin, Chinese University Hong Kong, School of Biomedical Sciences, Hong Kong, China

Register before September 27 to take advantage of the pre-meeting registration discount and to

avoid long lines at the registration counter.

Visit www.issx.org/international2013/registration today.

Maximize Your Time in Toronto by Attending an ISSX Short Course!

Visit www.issx.org/international2013/shortcourses for complete course details.


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Parallel Session 6: Cell Type Specific Mechanisms of Adverse Drug Reactions | Harbour Ballroom

Chair: Michael Aleo, Pfizer, Global Research and Development, Groton, CT, USA

Free Afternoon in Toronto | 14:00

Wednesday, October 2, 2013


Plenary Session 3: Identification and Use of Novel Biomarkers for Xenobiotic-Induced Toxicity | Frontenac

Chair: Malle Jurima-Romet, Celerion, Drug Development, Hudson, QC, Canada


Parallel Session 7: Targeted Drug Delivery for Enhanced Therapy | Frontenac

Chair: Christine Allen, University of Toronto, Toronto, ON, Canada

Parallel Session 8: Use of PB-PK Modeling in Pharmaceutical Safety Assessment | Harbour Ballroom

Chair: Aleksandra Galetin, University of Manchester, Manchester, UK


Parallel Session 9: Regulatory Perspectives in Drug-Drug Interactions and Metabolites in Safety Testing | Frontenac

Chair: Greg Slatter, Amgen, Seattle, WA, USA

Parallel Session 10: Toxicogenomic and Metabolomic Profiling: Current Status and Future Utility in Assessing Drug Efficacy and Safety | Harbour Ballroom

Chair: Tim Zacharewski, Michigan State University, East Lansing, MI, USA

ISSX Party at the Hockey Hall of Fame | 19:00 – 22:00

Enjoy a delicious buffet dinner, catch up with friends, and meet new acquaintances at the ISSX Party at the Hockey Hall of Fame! This is a ticketed event and a separate fee of $100 applies.

Thursday, October 3, 2013


Plenary Session 4: Genetically Modified Animal Models for Predicting Human Drug Disposition and Response | Frontenac

Chair: Xinxin Ding, Wadsworth Center, NYSDOH, Albany, NY, USA

Poster Awards Presentation | 10:30 – 10:45

2013 International Meeting Poster Awards Presentation | Frontenac


Parallel Session 11: Tissue Imaging and Distribution Studies in Drug Development | Frontenac

Chair: Yasuyoshi Watanabe, RIKEN Center for Life Science Technologies, Kobe, Japan

Parallel Session 12: Development and Uses of Hepatocyte-Derived and Hepatocyte-Like Cells for Predicting Human Drug Metabolism | Harbour Ballroom

Chair: Martine Daujat-Chavanieu, INSERM, Montpellier, France

Douglas A. Lauffenburger is Ford Professor of Bioengineering and Head of the Department of Biological Engineering at

MIT, and also holds appointments in the Department of Biology and the Department of Chemical Engineering. He is a member of the Koch Institute for Integrative Cancer Research, the Center for Biomedical Engineering, the Center for Environmental Health Sciences, and the Center for Gynepathology Research.

Dr. Lauffenburger’s BS and PhD degrees are in chemical engineering from the University of Illinois and the University of Minnesota, in 1975 and 1979 respectively. His major research interests are in cell engineering: the fusion of engineering with molecular cell biology. Lauffenburger has coauthored a book entitled Receptors: Models for Binding, Trafficking & Signaling, published by Oxford University Press in 1993, and coedited another entitled Systems Biomedicine, published by Elsevier Press in 2010. More than 90 doctoral students and postdoctoral associates have completed their training under his supervision or co-supervision.

Prof. Lauffenburger has served as a consultant or scientific advisory board member for Astra-Zeneca, Beyond Genomics, CellPro, Eli Lilly, Entelos, Genstruct, Insert Therapeutics, Johnson & Johnson, Merrimack Pharmaceuticals, Pfizer, Precision Therapeutics, SyStemix, the Burroughs-Wellcome Fund, and the Whitaker Foundation. He is a member of the National Academy of Engineering and of the American Academy of Arts & Sciences, and has served as President of the Biomedical Engineering Society, Chair of the College of Fellows of AIMBE and on the Advisory Council for the National Institute for General Medical Sciences at NIH.


OPENING KEYNOTE LECTURE: Systems Pharmacology – Systems Biology

Meets Drug Discovery & Development

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2013 International ISSX Awards

The R.T. Williams Distinguished Scientific Achievement Award Sponsored by Charles Crespi and Family

The 2013 R.T. Williams Distinguished Scientific Achievement Award is presented to an ISSX member or non-member from any region that has made substantial and seminal scientific contributions to the field over a sustained period. The focus of this award is the individual’s scientific accomplishments and it is intended to

recognize the best in the field, internationally. The 2013 recipient is Yuichi Sugiyama, Ph.D., RIKEN Innovation Center, Research Cluster for Innovation, Japan.

Professor Sugiyama is a world leader in drug transporters and physiologically-based pharmacokinetics. His work is firmly based on quantitative principles whereby drugs are absorbed, reach their target tissue (to produce their pharmacological effect), are metabolized, and eventually excreted. A central goal of his research is to establish reliable predictions of drug action in vivo, thereby optimizing drug therapy. By integrating physiological, molecular, and genetic studies with pharmacokinetics, Professor Sugiyama has created a new research area—Molecular Pharmacokinetics. A physiologically-based molecular pharmacokinetic model takes into consideration all relevant processes in the body. Professor Sugiyama dissects these processes by creatively interweaving a range of approaches that include mathematical modeling, pathophysiology, enzyme kinetics, genetics, and the molecular biology of receptors, enzymes and transporters. His work has succeeded to a degree unmatched by any other laboratory. Of particular note is Professor Sugiyama’s leadership in the field of drug transporters — he has published many seminal papers in this area. Detailed in vitro studies with transporters now allow prediction of transporter-mediated drug-drug interaction in vivo, while genetic variations in transporter genes are being identified in his laboratory that can account for inter-

individual differences in drug disposition and response.

Overall, Professor Sugiyama has produced a remarkable body of scientific work, with a profound impact on how we understand the pharmacokinetics, pharmacodynamics and use of drugs. Professor Sugiyama was ranked by ISI as the most highly cited scientist in Pharmacology and Toxicology over the period 1997-2007.

Professor Sugiyama has been actively involved in professional organizations for decades. Notably, he served as a Councilor of ISSX from 1998 – 2003 and was elected President-Elect in 2004. He then served as president of ISSX from 2006-2007 while concurrently serving as the President of JSSX. He was Chair of the Pharmaceutical Sciences World Conference in Kyoto in 2004, and has served as co-chair of a multitude of highly regarded international symposia over the years.

To recognize and celebrate Professor Sugiyama’s substantial and sustained scientific contributions to the field of xenobiotic disposition spanning almost four decades, he is awarded the 2013 R.T. Williams Distinguished Scientific Achievement Award.

Award Presentation and Lecture: Monday, September 30 | 11:00 – 12:00 | FRONTENAC

The Frederick J. Di Carlo Distinguished Service Award

The 2013 Frederick J. Di Carlo Distinguished Service Award is presented to an ISSX member from any region with an illustrious record of important service to the Society and its goals. The 2013 recipient is Robert P. Hanzlik, Ph.D.

Professor Hanzlik has a history of service to ISSX and its goals. A charter member of the Society, Professor Hanzlik helped establish what has become the premier association for academic and

industrial researchers in this area. In the early years he worked diligently to advance ISSX by serving in leadership and service roles including Councilor (1984-1987) and

ISSX CAREER CENTERDo you know about the ISSX Career Center?

Searching for experts in the field of drug metabolism, pharmacokinetics, pharmacodynamics, and other related areas? The ISSX Career Center job board is your premier resource to find skilled applicants.

• Create Your Company Profile free of charge and explain the organization and work environment in detail. • When your positions are advertised on the ISSX Career Center, an e-mail advertising the position is sent automatically to job

seekers who have requested notifications about opportunities matching their search criteria.• Browse Resumes for free and pay only for the resumes that you select.

Post your jobs online today! When you use the ISSX Career Center, you ensure that your open positions are advertised in the right place. Visit www.issx.org/careercenter.


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as the first chairman of the Scientific Affairs Committee (1986-1987). He was active in organizing meetings, serving as the program co-chairman for the very first ISSX North American Symposium (1985) and organizing and presenting a short course titled “Reactive Metabolite Chemistry for Toxicologists” at the 2nd North American ISSX Meeting in Florida, organized by Fred Di Carlo and Richard Welch (1987). During the early 1990’s as ISSX grew, Professor Hanzlik’s steady hand and attention to detail significantly contributed to both the ISSX Bylaws Committee (1991) and the Publications Committee (1991-1995). Professor Hanzlik has also organized several successful symposia and short courses for ISSX (6th North American ISSX Meeting in North Carolina in 1994) and Program Committee member for the 4th International ISSX Meeting in Seattle (1995). Professor Hanzlik then accepted the highest levels of ISSX leadership and responsibility as ISSX president-elect (1994 and 1995), president (1996-1997) and past president (1998 -1999), providing a well-organized and strong leadership vision.

In addition to his record of outstanding support and leadership to ISSX, Professor Hanzlik brings honor to ISSX as a distinguished scientist with an international reputation and as a leading trainer of more than 50 graduate students and post-doctoral fellows who now occupy positions in the pharmaceutical industry, non-profit organizations, and academia. He has published in excess of 150 scientific papers and has served as a member of editorial and advisory boards for several prestigious scientific journals.

For his involvement, leadership, expertise, contributions, and commitment, ISSX is proud to honor Professor Robert P. Hanzlik with the 2013 Frederick J. Di Carlo Distinguished Service Award.

Award Presentation: Monday, September 30 | 11:00 – 12:00 | FRONTENAC

Special Event: ISSX Party at the Hockey Hall of FameJoin your fellow attendees at a museum and entertainment destination like no other. Enjoy a delicious buffet dinner, catch up with friends, and meet new acquaintances at the ISSX Party at the Hockey Hall of Fame! Located in an architecturally ornate former bank building in downtown Toronto, the Hockey Hall of Fame is only three blocks from the Westin Harbour Castle Hotel. This spectacular museum is a highly unique venue that presents Canada’s national sport through the world’s largest collection of hockey artifacts and the fun of interactive games. Attendees can take shots at real-time goalies, stop the shots of Gretzky and Messier, call the play-by-play of some of hockey’s greatest goals, get up close and personal with the Stanley Cup in the museum’s vault, and explore the largest collection of hockey memorabilia in the world. A separate fee of $100 applies for this event ticket.

Be sure to select this registration option and plan to attend.

10th International ISSX Meeting Exhibitors

The 10th International Meeting will feature an exhibition showcasing the products and services

that researchers need to advance their work. The exhibition begins with the welcome reception on Sunday evening and continues throughout the

meeting. Meet with representatives from top suppliers and maximize the value of your attendance!

The following companies will exhibit at the 10th International ISSX Meeting. To add your

company to the list of exhibitors, visit www.issx.org/international2013/exhibits.

AB SCIEXAgilux LabsAIM Research CompanyAlliance Pharma, Inc.Alturas Analytics Bioreclamation IVTBruker DaltonicsBusan, South Korea,

11th International ISSX Meeting

Charles RiverCNBE INRSCorning Life SciencesCovance, Inc.CypexCyprotexEicom USAFrontage LabsHepregen Corporation

HepatoChemHuntingdon Life SciencesHurel CorporationInternational Institute

for the Advancement of Medicine (IIAM)

InterVivo SolutionsIn Vitro ADMET

Laboratories, LLCLablogic Systems LimitedLhasa LimitedLife Technologies

MicroConstantsMPI ResearchNexcelom BioscienceOptibriumOptivia Biotechnology PhoenixBio USA CorporationPromega CorporationPuracyp, LtdQPS Hepatic BiosciencesQualyst Transporter

Solutions, LLCQuintilesQuotient BioresearchSafeSciMETSAGE LabsSigma Life ScienceSimulations Plus, Inc.SOLVO BIOTECHNOLOGYTaconicTandem LabsThermo Scientific (part of

Thermo Fisher Scientific)Triangle Research LabsUniversity of Washington,

Drug Interaction Database Program

Waters CorporationXenoBiotic

Laboratories, Inc.XenoTech, LLC


Exhibitor listing as of August 27, 2013.

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Hotel, Travel, and VisaHotel rooms have been reserved at the Westin Harbour Castle Hotel at a special rate of $215 CAD for ISSX attendees. Book a room online by Monday, September 9, 2013 to obtain the special attendee rate.

Located 28 km from Pearson International Airport (YYZ), the hotel is easily accessible by airport shuttle, public transportation, taxi, and rental car.

Depending on the agreements between Canada and your country, a visa may be required. Please check with your local embassy/consulate or travel agent to obtain information regarding visa requirements. If you require a letter of invitation in order to obtain a visa please contact ISSX at [email protected].

Visit www.issx.org/international2013/accommodations for more information.

Industry-Sponsored SymposiaIndustry-Sponsored Symposia (ISS) are commercially-supported educational and promotional activities held

in conjunction with the 10th International ISSX Meeting. Although not an official part of the 10th International ISSX Meeting, these programs have been reviewed and these presentations permitted by MDO and ISSX.

If you are attending the 10th International ISSX Meeting, make plans to participate in the morning Industry-Sponsored Symposia offered:

Scheduled Industry-Sponsored Symposia Presentations

Monday, September 30 | 07:45 - 08:45 | Concurrent Symposia

Promega Corporation | Pier 4/5USING MULTI-PARAMETRIC OPTICAL ASSAYS WITH SPECIALIZED CELL-TYPES TO ENHANCE THE BIOLOGICAL RELEVANCE OF EARLY ADMET SCREENINGPresented by: James Cali, Promega Corporation

Thermo Scientific | Harbour BallroomAPPLICATIONS OF HRAM AND NEW TOOLS FOR METABOLITE IDENTIFICATION Presented by: Tim Stratton, Thermo Fisher Scientific and Jeff Gilbert, DOW Agro Sciences

Tuesday, October 1 | 07:45 - 08:45 | Concurrent Symposia

Bruker Daltonics | Harbour BallroomMALDI IMAGING MASS SPECTROMETRY: BRIDGING BIOLOGY AND CHEMISTRY TO ADVANCE DRUG DEVELOPMENT Presented by: M. Reid Groseclose and Stephen Castellino, GlaxoSmithKline

Corning Incorporated | Pier 4/5USING CELL-BASED AND RECOMBINANT MODELS IN DRUG TRANSPORTPresented by: Na Li, Ph.D. and Inese Smukste, Ph.D., Corning Incorporated

Wednesday, October 2 | 07:45 - 08:45 | Concurrent Symposia

Hepregen Corporation | Harbour BallroomHEPATOPAC™ MICROPATTERNED CO-CULTURE SYSTEM - AN IMPROVED IN VITRO MODEL FOR METABOLITE IDENTIFICATION AND COMPOUND STABILITYPresented by: Edward LeCluyse, Hamner Institutes for Health Sciences

Bioreclamation IVT | Pier 4/5PREDICTIONS OF IN VIVO HETEROTROPIC ACTIVATION OF CYTOCHROME P450 ENZYMATIC ACTIVITY FROM IN VITRO SYSTEMSPresented by: Anna L. Bloblaum, Bioreclamation IVT


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CellTox™ Green More Biology, Less Work

To see how easy better biology can be, request a free sample at:www.promega.com/ISSX13

©2013 Promega Corporation. All rights reserverd. 10192092

CellTox™ Green enables real-time mechanistic toxicity monitoring with a simple Add & Read protocol. Multiplexing with CellTiter-Glo® allows investigators to monitor temporal changes of membrane-modulated cytotoxicity in parallel with the key cell viability biomarker, ATP.

ISSX Invites Members to Organize Scientific Meetings

ISSX meetings provide invaluable opportunities for learning, networking, and exploring new ideas. Organizing an ISSX scientific meeting is a significant responsibility but also a tremendously valuable experience. Those who organized ISSX scientific meetings earn the gratitude of their contemporaries and add a highly impressive credit to their curriculum vitae.

Visit www.issx.org for more information including the document “Guidelines for the Organization of ISSX Meetings,” for sample meeting proposals, and for the meeting proposal submission form.

Please direct inquiries to the ISSX Executive Director, Steven Kemp, at [email protected].

ISSX Supporters and 10th International ISSX

Meeting SponsorsISSX Supporters

10th International Meeting Sponsors

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ISSX Welcomes New 2013 Members!Olumide Ajani, University of Ibadan, Nigeria

Adekunbi Aluko, University of Ibadan, Nigeria

Sara Amberntsson, Global DMPK, Sweden

Guohua An, University of Florida, United States

Sandra Appiah, Middlesex University, United Kingdom

Lars Blumenstein, Novartis Pharma, Switzerland

Jayaprakasam Bolleddula, Theravance, Inc., United States

Joris Braspenning, Medicyte GmbH, Germany

Tom Chan, Boehringer Ingelheim Pharmaceuticals, United States

Chun-Lin Chen, Medicilon, Japan

Young-Won Chin, Dongguk University, Korea

Young Hee Choi, Dongguk University, Korea

Mukund Chorghade, Empiriko Corporation, United States

Laurent Chouchana, Université Paris Descartes, Sorbonne Paris Cité, France

Edwin Chow, University of Toronto, Canada

Jae Yong Chung, Seoul National University Bundang Hospital, Korea

Ines De Lannoy, InterVivo Solutions, Inc., Canada

Isabelle De Waziers, INSERM, France

Bo Feng, Pfizer Inc., United States

Pierre-Jean Ferron, Anses, France

Keizo Fukushima, Kobe Gakuin University, Japan

Gerhard Gross, Janssen, Belgium

Xiaowen Guan, United States

Young Hwan Ha, Curachem, Inc., Korea

Hyekyung Han, Korea

Jessica Hartman, University of Arkansas for Medical Sciences, United States

Robin Haw, OICR, Canada

Charles Hendricks, Organovo, United States

Alain Heron, Imabiotech, France

Kevin Hogeveen, Anses, France

Zhanying Hong, School of Pharmacy, Second Military Medical University, China

Steven Hu, Zoetis, United States

Marycarmen Hurtado, Cinvestav-IPN, Mexico

Sabariah Ismail, Universiti Sains Malaysia, Malaysia

Sylvie Kandel, Xenotech LLC, United States

Seokuee Kim, Seoul National University College of Medicine, Korea

Mirim Kim, Korea

Min-Jung Kim, Korea

Sangsoo Kim, University of Guelph, Canada

Yun Sik Kim, Curachem, Inc., Korea

Gordon Kirby, University of Guelph, Canada

Tarra Knotts, United States

Risako Kon, Japan

Aurelie Krol, INSERM, France

Yoshiki Kusunoki, Japan

Diana Lambert, Xenotech, LLC, United States

Seok-Yong Lee, Sungkyunkwan University, Korea

Mey Lee, Amgen, United States

Minwoo Lee, Green Cross Corp., Korea

Remi Magnan, Solvo Biotechnology, Hungary

Edward Meek, United States

Larry Morgan, University of Guelph, Canada

Clayton Otwell, XenoTech, United States

Soo Heui Paik, Boryung Pharm., Korea

Jihye Park, Korea

Juhee Park, Curachem, Inc., Korea

Yan Qin, Pronova Biopharma, Norway

Debora Roaquin, Astrazeneca Pharmaceuticals, United States

Andrew Rowland, Flinders University, School of Medicine, Clinical Pharmacology, Australia

Svetlana Sapelnikova, KMT Hepatech Inc., Canada

Kari Schlicht, Agilent Technologies, United States

Taurence Senn, University of Washington, United States

Karine Sevin, GALDERMA R&D, France

Miki Shimada, Tohoku University Hospital, Japan

Sook Jung Shin, Curachem, Inc., Korea

Dawn Stricker, Optivia Biotechnology, United States

Huadong Sun, Bristol-Myers Squibb, United States

Vibeke Hougaard Sunesen, LEO Pharma A/S, Denmark

Jana Swenke, Kaye/Bassman, United States

Apana Takwi, St. Jude Children’s Research Hospital, United States

Ravi Talluri, Glenmark Pharmaceuticals, India

Fuxing Tang, Forest Labs, Inc., United States

Kazuhiro Tetsuka, Astellas Research Institute of America, United States

Walid Touati, INSERM, France

Thuy Tran, Amgen, Inc., United States

Ilya Tsyrlov, XENOTOX, Inc., United States

Ayse Ufuk, University of Manchester, United Kingdom

Gillian Wallace, Life Technologies, United Kingdom

Peter Ward, Janssen, United States

Peter Webborn, AstraZeneca, United Kingdom

Ian Westley, The Queen Elizabeth Hospital, Australia

Zhihong Yang, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, China

Zhiyuan Yin, Western University, Canada

Jingjing Yu, University of Washington, Dept. of Pharmaceutics, United States

Liming Zhang, Takeda Pharmaceutical Company Ltd., United States


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NOMINATE A COLLEAGUE FOR THE 5TH ASIA PACIFIC ISSX MEETING AWARDS

Nominations are now being accepted for the following awards to be presented at the 5th Asia Pacific ISSX Meeting May 9-12, 2014. The two awards to be presented at this meeting are:

Asia Pacific Scientific Achievement Award - Presented to an ISSX member who has made major scientific contributions to the field in the Asia Pacific region. The purpose of this award is to recognize meritorious contributions by senior or mid-career scientists that have had a major impact on research in the field. The award will consist of a plaque or medal, an honorarium, and travel support to the 5th Asia Pacific Meeting in Tianjin, China where a lecture will be presented by the awardee.

Asia Pacific New Investigator Award - Presented to an ISSX member who has made significant contributions to the field during their early career years (normally within 5 -10 years from the time of receiving his/her highest earned degree). The purpose of this award is to encourage and recognize developing scientists who are active in the field within the Asia Pacific region. The award will consist of a plaque or medal, an honorarium, and travel support to the 5th Asia Pacific ISSX Meeting in Tianjin, China.

Visit www.issx.org/awards/nominations to learn more and submit a nomination.

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Submit an abstract for the 5th Asia Pacific ISSX Meeting in Tianjin, China May 9-12, 2014.Visit www.issx.org/5asiapacific/abstracts to submit an abstract. Abstract submissions for the general poster presentations and Poster Awards Competition are due by Friday, January 31, 2014.

ISSX 2013 MembershipRenew with ISSX for the 2013 Membership term to receive steep registration discounts for the 10th International ISSX Meeting!

www.issx.org/Membership.

Are you attending the 10th International ISSX Meeting? Join fellow attendees for a delicious dinner in a unique venue that presents Canada’s national sport through the world’s largest collection of hockey artifacts and the fun of interactive games. Attendees can take shots at real-time goalies, stop the shots of Gretzky and Messier, call the play-by-play of some of hockey’s greatest goals, get up close and personal with the Stanley Cup in the museum’s vault, and explore the largest collection of hockey memorabilia in the world. This is the premier social event at this meeting and no better place for attendees to catch up with old friends and make new acquaintances.

A separate registration fee of $100 applies. Tickets may still be available.

Attendees can either meet in the hotel lobby at 18:45 or meet at the Hockey Hall of Fame located a short walk from the hotel at 30 Yonge Street.

Add this event to your meeting schedule! Log in to update your registration at: www.issx.org/international2013/registration

Join ISSX on Wednesday, October 2 for a Party at the Hockey Hall of Fame!


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ISSX Member Spotlight

What do you think the future of xenobiotic research will look like?

What excites you about your research?

What advice can you offer to students and young investigators?

Answer these questions and you could be featured in our next newsletter.

Complete the form online: www.issx.org/Membership/Spotlight

UPCOMING MEETINGS

10th International ISSX Meeting The Westin Harbour Castle Hotel

Toronto, Ontario, Canada September 29 – October 3, 2013

5th Asia Pacific ISSX Meeting

Tianjin, China May 9 – 12, 2014

29th JSSX and 19th North American

ISSX Meeting Hilton San Francisco

San Francisco, California, USA October 19 – 23, 2014

20th North American ISSX Meeting

Hilton Orlando Bonnet Creek Orlando, Florida, USA

October 18 – 22, 2015

11th International ISSX Meeting Busan Exhibition and Convention Center

Busan, Korea June 12 - 16, 2016

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The complete resource for all biologicalsBioreclamationIVT.com

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Pick-up our latest microsome data sheet and get a free giveaway.

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Deadline for the submission* of material to the ISSX Office:

ISSUE MATERIALS DEADLINE RELEASE DATE

Issue 4, 2013 October 11, 2013 November 2013

*Subject to change

Editor Dr. Allen Cato, IIICato Research, LTD6480 Weathers Place, Suite 104San Diego, California 92121USATelephone: +1-858-452-7271Fax: +1-858-452-7784E-mail: [email protected]

ISSX Newsletter is published quarterly in the spring, summer, autumn, and winter. For information concerning advertising in this publication, including rates and specifications, please visit www.issx.org or contact [email protected].

Advertise with ISSX in the quarterly ISSX Newsletter. Rates and additional advertising opportunities are available at www.issx.org/advertising.

Change of AddressIf your mailing address, telephone, fax number, or e-mail has changed or will change, please let us know as soon as possible. You may update your contact information at any time using the online membership directory, which you can access in the Member Only section of the Web site. If you have forgotten your username and/or password, please contact [email protected].

Advertise with ISSX

The quarterly ISSX Newsletter is an online publication featuring Society updates, scientific articles of interest, book reviews, summaries of ISSX meeting proceedings,

and more. This publication is designed to update the ISSX membership on the activities and events of the organization

and to provide an information forum.

The ISSX Newsletter reaches every ISSX.org site visitor as well as the ISSX membership.

Visit www.issx.org/advertising2013 today!


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ISSX Newsletter | Issue 3, 2013

Documents

international meeting

attended issx meeting

issx presidentread

issx leadership

isolation of natural

desired products

international travelers

university of toronto