1 Vermont Lung Center University of Vermont Charlie Irvin PhD WAO Cancun, Mexico December, 2011 Physiology of the Small Airways The image cannot be displayed. Your Questions 1) Is the physiology of a small airway different? 2) and Why should I care? Pathophysiology of Asthma Common Wisdom
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Vermont Lung Center University of Vermont
Charlie Irvin PhD
WAO Cancun, Mexico December, 2011
Physiology of the
Small Airways
The image cannot be displayed. Your
Questions
1) Is the physiology of a small airway different?
2) and Why should I care?
Pathophysiology of Asthma�Common Wisdom
2
“Silent Lung Zone”
Z 0 14
conductive airways acinar airways
1 2 3 4 5 15
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Weibel In Sci Foundations Of Lung Disease
What is a SMALL Airway ?
Est. 44,000
Structure has Consequences
Green M St Thomas Hosp Gazette 62:136 1964
8ηl R =
nπr4
Macklem PT and Mead J App Physiol 22:395 1967
Retrograde Catheter Paleophysiology
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Macklem and Mead J App Physiol 22:395 1967
Retrograde Catheter Hogg et al N Engl J Med 278:1355 1968
Hogg et al N Engl J Med 278:1355 1968
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Control of Airway Caliber & Patency
Smooth Muscle
Nerves
Structure
VOLUME
?
Green M St Thomas Hosp Gazette 62:136 1964
From Hogg JC. 1978. The Respiratory Airways. In Clinical Aspects of Respiratory Physiology, ed. CA Guenter, MH Welch, JC Hogg, pp. 38-71. Philadelphia: J.B. Lippincott Company