• Unpleasant taste • Tooth darkening • Diarrhea • Constipation • Pyrosis • Nausea • Vomiting Side-effects of iron The low bioavailability of iron leads to higher supplementation doses, thus resulting in increased adverse effects. Ca Fe Ca Fe Fe AB-Fortis® can help overcome the challenges Mouth: • Minimum contact with iron • No metallic taste, no tooth darkening, and good palatability (small particle size) Stomach: • Acid pH, low release of iron Stomach and intestine: • Use of Fe(lll) salt with fewer adverse effects Adequate compliance: • Reduced adverse effects Iron efficiency: • Increased bioavailability Intestine: • Bioavailability enhanced by chelation + High bioavailability but - Metallic taste - Reactive, carrier oxidation (e.g. rancidity of lipids) Soluble iron salts Meat Vegetarian meat analogues Cereals + No taste + Iron is not reactive + Controlled release: high bioavailability Encapsulated soluble iron salt Global # affected in millions • Preschool-age children • Pregnant women • Non-pregnant women 293.1 56.4 468.4 Cognitive performance in children and increased tiredness in women Impaired psychomotor development Microencapsulated iron salt High concentration of iron (40%) No metallic taste or negative interactions High stability Cost effective Bioavailability confirmed by published human study Results of comparative study: AB-Fortis® equally bioavailable as FeSO 4 -3,0 -2,0 -1,0 0,0 1,0 2,0 3,0 4,0 5,0 6,0 Baseline 0h 1h 2h 3h 4h 5h 6h Increase in Transferrin Saturation (%) Control AB-Fortis Meat and Savoury Milk, yoghurt Vegetarian proteins and meat alternatives Bakery Gummies & candy Drinks Dairy IRON NEVER TASTED SO GOOD MICROENCAPSULATED IRON Iron deficiency is a global health problem affecting around a billion people Iron fortification and supplementation face many challenges & of people in developed countries Affects around 20% in some developing countries Up to 60% Data from WHO report: The global prevalence of anaemia in 2011 Iron deficiency is a global health problem More prevalent in children under 6 years old and in women of childbearing age Introducing AB-Fortis®: Encapsulated soluble iron salt with patented microencapsulation technology Providing highly stable encapsulation that prevents the release of free iron in the food matrix Data from WHO report: The global prevalence of anaemia in 2011 Contreras et al. European Journal of Nutrition 2013 Mostly associated with: + No taste + Iron is not reactive: minimal oxidation of the carrier but - Bioavailability is low or non-existing Insoluble iron salts AB-Fortis® can be used in many food applications AB-Fortis® has a bioavailability equivalent to that of ferrous sulphate AB-Fortis® = easy iron supplementation and fortification