IR-4 National Meeting Sept. 2007 Tampa, FL Nichino America Inc. Jim Adams, Manager, Product Development Marie Maks-Regulatory Affairs Manager Phone: (302)

IR-4 National Meeting Sept. 2007Tampa, FL

Nichino America Inc.Jim Adams, Manager, Product DevelopmentMarie Maks-Regulatory Affairs ManagerPhone: (302) 636-9001Web site: www.nichino.net

Fenpyroximate

A miticide and insecticide Akari® 5 SC FujiMite® 5 ECPortal™ 5 EC

FENPYROXIMATE Miticide / Insecticide Activity

Excellent broad-spectrum miticide on row crops, fruit and vegetables Controls all life stages on contact Residual, non-lethal rates inhibit molting

Controls immature stages of leafhoppers, mealybug, citrus thrips, pear Psylla, Asian Citrus Psyllid and has contact activity on whitefly (including Q biotype)

Soft on beneficial insects and predatory mites Use rate of 0.05-0.2 lb. Active ingredient per acre One to two applications by ground only Important tool for resistance management Mitochondrial electron transport inhibitor

New IR-4 Crop Tolerances Established for 2007 Use Season Citrus crop group 10 Mint Hops Tree Nuts crop group 14

IR-4 and Interests for Fenpyroximate Strawberries Priority D (NC, CA, TN) +European data with

ChemSAC committee of EPA Caneberry Priority D (AR, NC, OK, GA) Avocado New PCR (CA) Banana New PCR (FL) Cantaloupe Priority B(FL) Petition under review Cucumber Priority C (AZ, NC, FL) Squash Priority E (NC) Eggplant-fruiting veg (NC, SC) Petition under review for crop group Sorghum Priority E (TX) Mango New PCR Snapbean (FL) New PCR

Canadian Submission

Greenhouse tomatoes and Cucumbers in 2009

Field crops and other greenhouse crops not confirmed at this time

Buprofezin

Courier 40 SCApplaud 70 DFCentaur WDGTalus 40 SC

Insects Controlled

Whiteflies Mealybugs, including Gill’s Leafhoppers, planthoppers, glassy-winged sharpshooter Soft scales: citricola, black, brown soft, white peach Armored scales: cactus, Calfornia red scale, Oystershell, San

Jose Use rate of 0.25-0.38 lbs. a.i./acre for in-row crops; 1.5-2.0 lbs.

a.i./ for pests on tree nut and tree fruit crops IGR that controls immature stages of insects (1st to 5th instar);

complements other IGRs and other insecticides Very soft on beneficials

IR-4 Recent New Tolerances

For 2008 use season: Stone Fruit Crop Group 12 Mango, papaya with 3 day PHI Grapes with 7 day PHI

IR-4 Residue Tolerance Petitions Submitted / Anticipated for Submission

to EPA Strawberry (notice of filing) PRIA date of July, 2008 Celery and Spinach to complete leafy vegetables (notice

of filing) PRIA date of July, 2008 Brassica vegetables (Crop Group 5) residues to be

completed calendar 2007 Eggplant / Bell Pepper/Okra (Crop Group 8) and 1 day

PHI on field and greenhouse tomatoes (submitted August, 2007 to EPA)

Olive (notice of filing) PRIA date of July, 2008 Cantalope, squash, cucumbers Coffee

IR-4 and Interests for Buprofezin

Broccoli (AZ, GA, CA, TX) Priority D: Manufacturer’s objective

Mustard Greens (NC, TX, NC, NJ, SC) Priority B Manufacturer’s objective

Turnip greens (NC,SC) Priority C Manufacturer’s objective

Collard greens (NC,SC) Priority D Pomegranate Priority E (CA)

Canadian Submission

By late 2007 for greenhouse tomatoes and cucumbers

Field crops and other greenhouse crops not confirmed at this time

Tolfenpyrad

NAI-2302 15EC

NAI-2303 15SC

Chemical Details on Tolfenpyrad Chemical Name: 4-chloro-3-ethyl-1-

methyl-N-[4-p-tolyloxy)benzyl] pyrazole -5-carboxamide

Empirical Formula: C21H22Cl N3O2

Molecular Weight: 283.9 Code Number: NAI-2302

Insects Controlled

Hemiptera, Coleoptera, Diptera, Lepidoptera, Thysanoptera, and Acarina

Poisoning by ingestion; contact activity; anti-feeding activity against leps

Target Crops: Vegetables, Cucurbits, Cole Crops Fruits & Nuts Selected row crops Ornamentals

Efficacy Trials

Use rate 0.137 to 0.274 lb. a.i/acre (153-307 grams ai / hectare)

14 – 27 oz/a (15% EC and 15% SC formulations)

IR-4 Interest

Green onions Priority D (SC) Dry bulb onions Priority E (NY) Ornamentals Priority A

Frankliniella occidentalis Epitrrix spp. Scirtothrips dorsalis Thrips simplex Popillia japonica Pyrrhalta viburni

U.S. Registration Timeline

Submit non-crop indoor greenhouse use early 2008 as reduced risk candidate

Submit crop uses with residue chemistry data by 2010 as reduced risk candidate

Canadian Submission

By 2008 for greenhouse use Field crops not confirmed at this time

Flubendiamide-Based Insecticides

NNI-0771

NNI-0772

NNI-0776

CF3

CF3F

I

O

NH

OCH3

HN

CH3CH3

SCH3

OO

NAI-2310 (FLUBENDIAMIDE)

New generation of chemistry active against Lepidoptera at low rates

Discovered by NNC and marketed by NNC and Bayer

Registered in Japan as Phoenix

FLUBENDIAMIDEProduct Characteristics

Flubendiamide (NAI-2310) Target Mkts: TNV, Vegetables, Cotton

Chemistry: Substituted phtallic acid diamide

MOA: Ryanodine receptor modulator

Ingestion by insect results in immediate cessation of feeding

Contact (not systemic in plants and has only limited translaminar movement)

Rates: 15-140 gms ai/hectare

US Registration Timeline

Submission to EPA 2008 Commercial Launch 2009

Pyrifluquinazon

NNI-0101

NNI-0101(Pyrifluquinazon)

Chemistry: Quinazolinone Chemistry

MOA: Insect Behavior Modifier Rapid cessation of feeding

Insects remain but starve to death

Target Mkts: TNV, Vegetables, Cotton, Cucurbits

Control of Hemiptera / HomopteraRates: 12.5-50 gms ai/hectareWhitefly control at very low ratesExcellent aphid and thrips controlGood mealybug and scale controlOK leafhopper (< imidacloprid)Stinkbug activity at high (>60 gms ai/acre) rate

NNI-0101 (Pyrifluquinazon)

Possible IR-4 Interests

Onion thrips (PCR submitted) Aphid, Thrip, Whitefly, Mealybug and

Scale control on ornamentals

US Registration Timeline

Submit as non-crop to EPA by 2009 Submit food crop uses by 2011

Nichino America Inc.

Website: www.nichino.net