Inverse Grid2-6 中中中中中中 ( Central lym phoid organ ) 骨骨骨骨骨骨( Bone Marrow and burs a of Fabricius ) 胸胸( Th ymus ) A bilobbed primary lymphoi d organ that is required f or the generation of immun ocompetent CD3CD4 and CD3C D8 cells necessary for ada ptive immune response.
Inverse Grid2-6 中枢免疫器官 ( Central lymphoid organ ). 骨髓和法氏囊( Bone Marrow and bursa of Fabricius ). A bilobbed primary lymphoid organ that is required for the generation of immunocompetent CD3CD4 and CD3CD8 cells necessary for adaptive immune response. 胸腺( Thymus ). - PowerPoint PPT Presentation
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Inverse Grid2-6 中枢免疫器官 ( Central lymphoid organ ) 骨髓和法氏囊( Bone Marrow and bursa of Fabricius )
胸腺( Thymus )
A bilobbed primary lymphoid organ that is required for the generation of immunocompetent CD3CD4 and CD3CD8 cells necessary for adaptive immune response.
2-6 中枢免疫器官 ( Central lymphoid organ ) 骨髓和法氏囊( Bone Marrow and bursa of Fabriciu
s ) 胸腺( Thymus ) A bilobbed primary lymphoid organ that is requir
ed for the generation of immunocompetent CD3CD4 and CD3CD8 cells necessary for adaptive immune response.
The thymus is made up of various cell type derived from different origin. Histologically, the thymus has three distinct components: subcapsular cortex, cortex and medulla. Development of T cells or thymucytes are found embedded in an epithelial network known as thymic stroma. The thymic anlage provides an inductive environment that allows precursor T cells to rapidly expand and differentiate.
2-7 外周淋巴器官( Peripheral lymphoid organ )
•粘膜相关淋巴系统 ( mucosa-associated lymphoid system )•脾脏( spleen )•淋巴结( lymphnodes )
•扁桃体( tonsil )
HEV are specialized venules found in lymphoid tissues. Lymphocytes migrate from blood into lymphoid tissues by attaching to and migrating across the high endothelial cells of the vessels.
Germinal centers in secondary lymphoid tissues are sites of intense B cell proliferation, selection, and death during Ab responses. Germinal centers form around follicular dendritic cell network when activated B cells migrate into lymphoid follicles.
•生发中心( germinal center )
右淋巴导管
流入右锁骨下静脉
颈部淋巴结
流入右锁骨下静脉 胸导管
胸导管
腋窝淋巴结
乳糜池
脊柱旁淋巴结
腹股沟淋巴结引流淋巴管
Lymph nodes are encapsulated strictures that are strategically placed throughout the body to receive and filter antigens and cells from peripheral interstitial fluid and lymph. All lymph nodes eventually drain into the thoracic duct and back to the peripheral blood.
Both T and B cells continuously circulate and recirculate, blood to lymph to blood. Approximately 1-2% recirculate every hour. NK cells are only found in blood, spleen and liver.