Introduction to the endocrine system Ziying WANG Institute of Pharmac ology School of Medicine, Shandong University [email protected] n
Jan 12, 2016
Introduction to the endocrine system
Ziying WANGInstitute of Pharmacology School of Medicine, Shandong [email protected]
Part 1 Introduction
Endocrinology
1. Definition: the study of hormones and their functions.
2. History: (1) Ancient China
(2) 1849, Berthold
(3) 1855, Addison’s disease
(4) Ernest Starling
1902, Hormone,
1905, “Endocrine system” Ernest Starling(1866-1927)
Endocrine vs. exocrine
Characteristic of endocrine gland
• Without duct
• The endocrine cells arranged in cluster, follicle or cords
• Rich in capillaries
• The secretion is hormone which transported by blood circulation
Endocrine system
1. Endocrine glands(1) Classical endocrine glands
(2) Extensive endocrine glands
2. Endocrine cells
Classical endocrine glands
Hormones
Definition -- chemical messengers
-- secreted by endocrine gland or cells
-- released into the blood
-- effect on target cells through receptors
Major Hormones
Hormones
Functions• to control the regulatory systems in the body
(1) homeostasis
(2) metabolism
(3) growth and development
(4) reproduction
Endocrine vs. Nervous regulationEndocrine vs. Nervous regulation
Neural regulation-exerts point-to-point
-control through nerves
-electrical in nature and fast
Endocrine regulation-broadcasts its hormonal messages to essentially all cells -by secretion into blood and extracellular fluid-requires a receiver to get the message
-slow and wider
Neuroendocrine regulation: 1928, Scharrer
Transportation of Hormones
Endocrine (Telecrine, hemocrine)
Paracrine
Transportation of Hormones
Types of hormones
1. Peptide hormones
2. Steroids
3. Amine hormones (derivatives of the amino acid tyrosine)
Synthesis of hormones
Synthesis of steroid hormones
Synthesis of amine hormones
Synthesis of peptide hormones
The comparison of hormones
Receptors Carrier
protein
Orally active
storage
Peptides Cell membrane
No Not usually Hormone
Steroids Cytoplasm/nucleus
Yes Yes, mostly Precursor
Thyroid hormone
nucleus Yes Yes Precursor
Catecholamines Cell membrane
No No Hormone
The transport of hormones
1. Peptide and CA: water-soluble2. Steroids and thyroid hormone: bound to proteinsEg. Thyroid hormones binding globulin (THBG)
Cortisol binding globulin (CBG)
Sex hormones binding globulin (SHBG)
Effects of hormone binding proteins:(1) Increase the solubility
(2) Create an accessible reserve
(3) Increase the biological half time
The metabolism of hormones
1. Peptide hormones: degradation in a lysosome
2. Steroids: excreted in an unchanged form
3. Catecholamines: COMT and MAO
4. Thyroxine: removing the iodine residues
Results of metabolism(1) Inactivation
(2) Activation
Properties of the hormone effect
1. Specificity
2. Signal transmission
3. High biological efficiency
Properties of the hormone effect
1.Specificity: target, receptor
Properties of the hormone effect
2. Signal transmission
Properties of the hormone effect
3. High Biological Efficiency
Low plasma concentration
(nmol – pmol/L)
→great regulatory function
Part 2 Important concepts in endocrine regulation
Patterns of hormone secretion
Different hormones have markedly different patterns of secretion.
1. Set point regulation
2. Episodic secretion
3. Diurnal variation
Regulation of hormone secretion:endocrine axis
Endocrine axis
1. Long-loop feedback: (1) Classical negative feedback (2) Regulated by the end product
2. Short-loop feedback Regulated by the intermediate product
3. Ultrashort-loop feedback
Regulation of hormone secretion: negative feedback
Regulation of hormones secretion
• 1. Synergistic effects
• 2. Permissive effect
• 3. Antagonist effects
Interaction Between the Hormones
• 1. Synergistic effects
(1) Additive: same effect of the hormones on one target organ
(2) Complementary: work on different stages of a physiological procedure
Interaction Between the Hormones
• 2. Permissive effect• A hormone enhances the responsiveness
of a target organ to the second hormone, and increases the activity of the second hormone.
Interaction Between the Hormones
3. Antagonist effects• One hormone antagonize the effects of anoth
er.• Eg. The regulation effect of glucagon and insulin on
blood glucose metabolism
Interaction Between the Hormones
Part 3 Endocrine disorders
Endocrine disorders
• Normal amount of hormones are essential for the body.
• Either excessive or insufficient hormones secretion are disorders.
• Excessive secretion: hyper-
• Insufficient secretion: hypo-
Endocrine disorders
Secondary: Hypothalamus or pituitary disorder
Primary: endocrine glands disorder
Endocrine disorders
Part 4 Endocrine investigations
General principles
1. Purposes: diagnosis/monitoring2. After clinical pattern recognition or
understanding of physiology and anatomy3. Blood test maybe basic or dynamic.1) Basic test : 9:00h, fasted2) Dynamic test: (1) stimulation test :when suspect a hormone is too low. (2) suppression test: when suspect a hormone is too high.
Measurement of hormones
1. Biological sample (1) Blood (2) Urine (3) Biopsy
2. Image: radiological imaging is vital.
Ectopic hormone secretion
1. Definition: The inappropriate secretion of hormones by tissues that do not usually produce that hormones.
2. Clinical significance: as a feature of endocrine tumors.
3. Diagnosis: combined methods.
Receptors and hormone actionThe first step of a hormone’s action is to bind to specific receptors at the target cell.
Protein in nature
(may contain carbohydrate or phospholipid moieties)
Classification by location:
1.Cell surface receptors
2. Intracellular receptors:
(1) cytoplasm receptors
(2) nucleus receptors
Receptors of hormones
Classification by mechanisms:
Receptors of hormones
1.Second messenger mechanisms:
Peptide hormones and CA
--bind the receptors on the membrane --activate some enzyme on the membrane-- regulate the concentration of second
messengers in the cytoplasm
Mechanism of hormones action
G-protein-coupled Receptor
Second messenger mechanisms
2. Gene expression mechanism:
Intracellular receptors(1) --bind the receptors in the cytoplasm -- HR complex goes into nuclearOr -- bind the receptors in the nuclear (2) -- bind to target DNA(3) – regulate transcription
Mechanism of hormones action
Gene expression mechanism
Gene expression mechanism
cytoplasm receptors nucleus receptors
3. Receptors activate a protein kinase
For insulin or growth hormone receptors
Mechanism of hormones action