7/29/2019 Intracranial Fetal Tumor Presentation
1/38
Ali Al-Ibrahim
MFM Fellow
7/29/2019 Intracranial Fetal Tumor Presentation
2/38
G1P0 of Japanese descent, 35+5 weeks of gestation
First seen at the low risk clinics
Healthy, no comorbidities Married, partner of Chinese descent
Hepatits B negative, VDRL negative, Rubella immune,Blood group A Rh +ve.
No smoking, no alcohol, no radiation exposure
Prenatal vitamins and Diclectin throughout pregnancy
7/29/2019 Intracranial Fetal Tumor Presentation
3/38
At 11+6, NT 1.2
IPS negative, adjusted risk of T21 = 1:1730
Anatomy ultrasound at 19 weeks normal Routine ultrasound done at 34+5 on March 27, 2012
7/29/2019 Intracranial Fetal Tumor Presentation
4/38
7/29/2019 Intracranial Fetal Tumor Presentation
5/38
7/29/2019 Intracranial Fetal Tumor Presentation
6/38
7/29/2019 Intracranial Fetal Tumor Presentation
7/38
7/29/2019 Intracranial Fetal Tumor Presentation
8/38
7/29/2019 Intracranial Fetal Tumor Presentation
9/38
7/29/2019 Intracranial Fetal Tumor Presentation
10/38
7/29/2019 Intracranial Fetal Tumor Presentation
11/38
7/29/2019 Intracranial Fetal Tumor Presentation
12/38
7/29/2019 Intracranial Fetal Tumor Presentation
13/38
7/29/2019 Intracranial Fetal Tumor Presentation
14/38
7/29/2019 Intracranial Fetal Tumor Presentation
15/38
7/29/2019 Intracranial Fetal Tumor Presentation
16/38
7/29/2019 Intracranial Fetal Tumor Presentation
17/38
7/29/2019 Intracranial Fetal Tumor Presentation
18/38
7/29/2019 Intracranial Fetal Tumor Presentation
19/38
In Summary G1P0, 35+5
Infra-tentorial mass (tumor) with obstructivehydrocephalus
Normal BPD and HC
7/29/2019 Intracranial Fetal Tumor Presentation
20/38
MRI on March 29th
, 2012
7/29/2019 Intracranial Fetal Tumor Presentation
21/38
Congenital Intracranial Tumors
Differential Diagnosis and Outcome
7/29/2019 Intracranial Fetal Tumor Presentation
22/38
Brain tumors occur less often in the first year of lifethan in the older child and adolescent
The peak age incidence in children is between 5 and 8years
Central nervous system neoplasms are the leadingsolid tumor in children and adolescents and are
surpassed only by leukemia and lymphoma infrequency
7/29/2019 Intracranial Fetal Tumor Presentation
23/38
During the perinatal period brain tumors arediagnosed less often than teratomas, neuroblastoma,and leukemia. However they cause over 10% of the
deaths due to neoplasms in this age period Two thirds of brain tumors in the fetus and infant
occur above the tentorium, the reverse is true for theolder child.
Some brain tumors occur in association with certainrenal tumors in infants and children, for example,cerebral primitive neuroectodermal tumor (PNET)and Wilms tumor and rhabdoid tumor
7/29/2019 Intracranial Fetal Tumor Presentation
24/38
7/29/2019 Intracranial Fetal Tumor Presentation
25/38
7/29/2019 Intracranial Fetal Tumor Presentation
26/38
7/29/2019 Intracranial Fetal Tumor Presentation
27/38
7/29/2019 Intracranial Fetal Tumor Presentation
28/38
Clin Neuropathol. 2001 Sep-Oct;20(5):181-9. Neonatal tumors of the CNS: a report of9 cases and a review.Ortega-Aznar A, Romero-Vidal FJ, de la Torre J, Castellvi J, Nogues P
Abstract
Neonatal central nervous system (CNS) tumors are an uncommon and histologicallyheterogeneous group of neoplasms with different clinical and biological features fromthose arising in childhood. We report 9 cases in which a diagnosis of CNS tumor wasconfirmed by biopsy or autopsy during the years 1982-1997 in the Vall d'HebrnChildren's Hospital, Barcelona. Two cases were fetal tumors detected by fetal sonography,3 patients were symptomatic in the first days after birth and 4 patients presented initialclinical signs in the first weeks or months of life. Eight lesions were supratentorial and 1was located in the spinal cord. According to histologic types, there were 2
glioneuronal tumors, 1 anaplastic astrocytoma, 1 choroid plexus carcinoma, 1 immatureteratoma, 1 craniopharyngioma, 1 hemangioblastoma, 1 astroblastoma and 1hemangioendothelioma. Extensive review of the literature indicates that our cases ofhemangioblastoma, astroblastoma and hemangioendothelioma are exceptional and onemore of the very rare and isolated previously published cases.
http://www.ncbi.nlm.nih.gov.myaccess.library.utoronto.ca/pubmed/11594502http://www.ncbi.nlm.nih.gov.myaccess.library.utoronto.ca/pubmed/11594502http://www.ncbi.nlm.nih.gov.myaccess.library.utoronto.ca/pubmed/11594502http://www.ncbi.nlm.nih.gov.myaccess.library.utoronto.ca/pubmed/11594502http://www.ncbi.nlm.nih.gov.myaccess.library.utoronto.ca/pubmed/115945027/29/2019 Intracranial Fetal Tumor Presentation
29/38
7/29/2019 Intracranial Fetal Tumor Presentation
30/38
7/29/2019 Intracranial Fetal Tumor Presentation
31/38
7/29/2019 Intracranial Fetal Tumor Presentation
32/38
7/29/2019 Intracranial Fetal Tumor Presentation
33/38
7/29/2019 Intracranial Fetal Tumor Presentation
34/38
7/29/2019 Intracranial Fetal Tumor Presentation
35/38
7/29/2019 Intracranial Fetal Tumor Presentation
36/38
7/29/2019 Intracranial Fetal Tumor Presentation
37/38
7/29/2019 Intracranial Fetal Tumor Presentation
38/38