INTERPRET - 1 Voxel localized spectrum Metabolic image Morphological image Pixel profile Nosologic image Classification Color code Overview.

INTERPRET - 1

Voxel localized spectrum

Metabolic imageMorphological image

Pixel profile

Nosologic image

ClassificationColor codeOverview

INTERPRET - 2

When entering the software…

INTERPRET - 3

For raw processing:

a set of default parameters is

proposed

Depending on the echo-time

(136 or 272 ms)

INTERPRET - 4

During the raw processing, information is displayed for the successive steps

INTERPRET - 5

The morphological image and a spectrum (real for 136 ms, magn for 272ms TE) are displayed

INTERPRET - 6

Next step is constructing the Metabolic images from the area of each peak

INTERPRET - 7

Default parameters are proposed for the line fitting

INTERPRET - 8

Spectra from the voxels in and around the VOI are then fitted

Constraints:- negative peaks for lactate and alanine- same linewidth

To add:- chemical shift constraints

INTERPRET - 9

All metabolic images are reconstructedThe clinician may visualize the different metabolic images to control the fitting process

INTERPRET - 10

For each voxel, the fitted spectrum can be overplot on the raw data

Erroneous fitting can be corrected, voxel by voxel

INTERPRET - 11

Next step is constructing the Nosologic image

INTERPRET - 12

What next ?

◊ Classification process (metabolites at 136 ms TE + water information) In progress - by Isabel Brito

◊ Improve pre-processing HLSVD Remove artefact from deconvolution process Baseline correction

◊ C-programming + Java interface In progress - by Blandine Chanteloup

INTERPRET - 13

The metabolic images are interpolated

The user has to draw an ROI in the healthy tissue on the water T2

image

INTERPRET - 14

From the 6 metabolic maps and the water information,

a profile is calculated for each pixel

INTERPRET - 15

The nosologic image is computed and displayed

For each pixel, the highest belonging degree is color encoded

INTERPRET - 16

Data may be printed, saved, or the clinician may load a new patient exam

INTERPRET - 17

The default morphological image may be changed…

INTERPRET - 18

Information is available on the different step results