International Conference on Immunology 2007

International Conference on Immunology 2007 Shanghai, China July 12-15, 2007

CALL FOR ABSTRACTS AND REGISTRATION

CONFERENCE CO-CHAIRS Xuetao Cao, M.D., Ph.D. Second Military Medical University, Shanghai, China Lieping Chen, M.D., Ph.D. Johns Hopkins University School of Medicine, Baltimore, USA Yong-Jun Liu, M.D., Ph.D. M.D. Anderson Cancer Center, Houston, USA

ORGANIZED BY

The Chinese Society for Immunology The National Natural Science Foundation of China

SECRETARIAT Institute of Immunology Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, China Phone: (+86-21)-5562 0605 Fax: (+86-21)-6538 2502 Email: [email protected]

http//www.immunol.org

INVITATION Dear Colleagues and Friends,

On behalf of the organizing committee, we would like to cordially invite you to participate in the upcoming “International Conference on Immunology 2007” to be held in Shanghai, China from July 12 to 15, 2007.

The conference is organized by the Chinese Society for Immunology and National Natural Science Foundation of China. The conference will provide a forum to bring together immunologists and scientists from around the world in related fields to review the latest progress and development, to exchange their experience, progress and ideas, and also to deepen their knowledge and broaden their understanding in basic and clinical immunology.

The conference will be held in Shanghai, one of the world’s most dynamic cities in the 21st century. China is a land of ancient culture with historical sites dating back to over 5000 years. We plan to have exciting social activities and sightseeing tours. We sincerely hope that this conference will bring you unforgettable memories.

Looking forward to meeting all of you in Shanghai, China in July. With best wishes, Xuetao Cao, M.D., Ph.D. President, Chinese Society for Immunology Director, Institute of Immunology Second Military Medical University Shanghai 200433, China

Lieping Chen, M.D., Ph.D. Professor of Dermatology, Oncology, and Immunology Director of Dermatology Research Johns Hopkins University School of Medicine Baltimore, MD 21231, USA

Yong-Jun Liu, MD, Ph.D. Professor and Chairman, Department of Immunology, Director, Center for Cancer Immunology Research, University of Texas, MD Anderson Cancer Center Houston, Texas 77030, US

SCIENTIFIC PROGRAM COMMITTEE Chairman: Zhigang Tian (Hefei, China) Members: Denian Ba (Beijing, China) Weifeng Chen (Beijing, China) Siyi Chen (Houston, USA) Jianzhu Chen (Cambridge, USA) Youhai Chen (Philadelphia, USA) Wanjun Chen (Bethesda, USA) Genghong Cheng (Los Angeles, USA) Chen Dong (Houston, USA) Gengsheng Feng (La Jolla, USA) Yangxin Fu (Chicago, USA) Xinyuan Fu (Indianapolis, USA) Feili Gong (Wuhan, China) You-Wen He (Durham, USA) Boquan Jin (Xi’an, China) Xiaokang Li (Takyo, Japan) Xiaoxia Li (Cleveland, USA) Yang Liu (Ann Arbor, USA) Xiaojing Ma (New York, USA) Beifen Shen (Beijing, China) Hao Shen (Philadelphia, USA) Yufang Shi (Piscataway, USA) Wenru Song (Dallas, USA) Xiao-Hong Sun (Oklahoma City, USA) Rongfu Wang (Houston, USA) Jiangping Wu (Montreal, Canada) Li Wu (Melborne, Australia) Xiaoning Xu (Oxford, UK) Xueguang Zhang (Suzhou, China) Dexian Zheng (Beijing, China)

LOCAL ORGANIZING COMMITTEE Chairman: Wei He (Beijing, China) Secretary General: Yizhi Yu (Shanghai, China) Treasurer: Yanfeng Wu (Shanghai, China) Members: Zhinan Chen (Xi’an, China) Yinghua Chen (Beijing, China) Zhiren Fu (Shanghai, China) Fu Gao (Beijing, China) Xiaoming Gao (Beijing, China) Boqing Li (Bangbu, China) Dianjun Li (Haerbin, China) Changlong Lu (Shenyang, China) Dalong Ma (Beijing, China) Hongbin Shu (Wuhan, China) Bin Sun (Shanghai, China) Wensheng Sun (Jinan, China) Hong Tang (Beijing, China) Fusheng Wang (Beijing, China) Runtian Wang (Shijiazhuang, China) Xiaoning Wang (Guangzhou, China) Yuquan Wei (Chengdu, China) Changyou Wu (Guangzhou, China) Yuzhang Wu (Chongqing, China) Sidong Xiong (Shanghai, China) Anlong Xu (Guangzhou, China) Angang Yang (Xi’an, China) Zhi Yao (Tianjing, China) Yongli Yu (Jilin, China) Jingwu Zang (Shanghai, China) Yaoying Zeng (Guangzhou, China) Yongtang Zheng (Kunming, China) Guangyan Zhou (Shanghai, China) Renqian Zhong (Shanghai, China) Xun Zhu (Jilin, China)

IMPORTANT DATES AND DEADLINES

May 15, 2007 Abstract submission deadline & end of early registration

May 15, 2007 Submission with regular registration fee

May 16, 2007 Submission with late registration fee

INVITED SPEAKERS Shizuo Akira (Osaka, Japan) James P. Allison (New York, USA) David Baltimore (Pasadena, USA) Alan Baxter (Queensland, Australia) Dirk Busch(Munich, Germany) Lieping Chen (Baltimore, USA) Genghong Cheng (Los Angeles, USA) Mohamed Daha (Leiden, The Netherlands) Chen Dong (Houston, USA) Yang-Xin Fu (Chicago, USA) Hao Shen (Philadelphia, USA) Guido Kroemer(Paris, France) Antonio Lanzavecchia (Bellinzona, Switzerland) Xiaoxia Li (Cleveland, USA) Dan R. Littman (New York, USA) Yong-Jun Liu (Houston, USA) Yang Liu (Ann Arbor, USA) Tak W. Mak (Ontario, Canada) Ruslan Medzhitov (New Haven, USA) Masayuki Miyasaka (Osaka, Japan) Luke O'Neill (Dublin, Ireland ) Klaus Rajewsky (Boston, USA) Yufang Shi (Piscataway, USA) Tada Taniguchi (Tokyo, Japan) Rongfu Wang (Houston,USA) Li Wu (Melborne, Australia) Laurence Zitvogel(Paris, France)

PROGRAM

International Conference on Immunology 2007 Shanghai, China July 12-15, 2007

July 13, 2007

8:00-8:30 Opening ceremony

Plenary session 1: Frontiers in Biomedicine

Co-chairs: Lieping Chen (USA) and Wei He (China)

8:30-9:30 Keynote Lecture

David Baltimore, California Institute of Technology, USA

New directions in immunology

9:30-9:55 Tak W. Mak, University of Toronto, Canada

Cell survival and death pathways in immunology

9:55-10:20 Klaus Rajewsky, Harvard Medical School, USA

MicroRNAs: new players in immunoregulation

10:20-10:55 Yong-Jun Liu, MD Anderson Cancer Center, USA

Plasmatoid dentritic cells: specific receptors and function

10:55-11:10 Coffee break

Plenary session 2: Adaptive Immunity

Co-chairs: Yong-Jun Liu (USA) and Zhigang Tian (China)

11:10-11:35 James P. Allison, Memorial Sloan-Kettering Cancer Center, USA

Immune checkpoint blockade in cancer therapy

11:35-12:00 Lieping Chen, Johns Hopkins University, USA

Costimulation and Coinhibition in the control of immune responses

12:00-12:25 Dan Littman, New York University, USA

Cytokine networks and transcriptional regulation in Th17 cell differentiation

12:25-12:45 Dirk Busch, Technical University Munich, Germany

In vivo generation of CD8+ effector and memory T cell subsets

12:30-14:00 Lunch and Poster View

Plenary session 3: Innate Immunity (I)

Co-chairs: Luke A. O’Neill (Ireland) and Xueguang Zhang (China)

14:00-14:25 Tada Taniguchi, University of Tokyo, Japan

Regulation of immune response and tumor suppression by the IRF family transcription factors

14:25-14:50 Shizuo Akria, Osaka University, Japan

TLR-dependent and independent anti-viral responses

14:50-15:15 Luke A. O’Neill, Trinity College Dublin, Ireland

Toll-like receptor signal transduction in innate immunity and inflammation

15;15-15:40 Ruslan Medzhitov, Yale University, USA

Endogenous retroviruses, innate immune recognition and autoimmunity

15:40-16:00 Coffee break

Plenary session 4: Innate Immunity (II)

Co-chairs: Mohamed Daha (The Netherlands) and Dexian Zheng (China)

16:00-16:25 Genghong Cheng, University of California Los Angeles, USA

IL-1β/IL-1R-mediated neutrophil recruitment gene program in host defense against Staphylococcus aureus infection

16:25-16:50 Xuetao Cao, Shanghai Second Military Medical University, China

Regulatory dendritic cells and TLR responses

16:50-17:15 Mohamed Daha, Leiden University Medical Center, The Netherlands

Role of Complement in innate host defense and autoimmunity

17:15-17:35 Xiaoxia Li, Cleveland Clinic Foundation, USA

Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease

17:35-18:00 Xin-Yuan Fu, Indiana University School of Medicine, USA

STAT3 is a key regulator of immune tolerance

July 14, 2007 8:00-12:30

Symposium (I): Immune Regulation and Immunotherapy

Co-chiars: Yong-Guang Yang (USA) and Jingwu Zang (China)

8:00-8:25 Yong-Guang Yang, Harvard Medical School, USA

SIRPα signing in macrophages: its regulation and role in xenotolerance induction by mixed chimerism

8:25-8:50 Jingwu Zang, Shanghai JiaoTong University School of Medicine and Chinese Academy of Sciences, China

Induction of adaptive CD4+CD25+Foxp3+ regulatory T cell response in autoimmune disease

8:50-9:15 Zhinan Chen, Fourth Military Medical University，China

Therapeutic antibody- based cancer therapy

9:15-9:40 Shu-Hsia Chen, Mount Sinai School of Medicine, New York , USA

Reversion of immune tolerance by modulation of myeloid derived suppressor cell development in advanced malignancy

9:40-10:05 Yusen Liu, The Ohio State University College of Medicine and Public Health, USA

Knockout of Mkp-1 enhances the host inflammatory responses to gram-positive bacteria.

10:05-10:30 coffee break

10:30-10:55 Liwei Lu, The University of Hong Kong，China

Role of B cell activating factor in the pathogenesis of autoimmune arthritis

10:55-11:20 Zusen Fan, Chinese Academy of Sciences, China

Heat shock protein 75 (TRAP1) antagonizes ROS generation and protects cells from granzyme M-mediated apoptosis

11:20-11:45 Xueguang Zhang, Soochow University, China

Two-signal model and co-signal network

11:45-12:10 Sidong Xiong, Fudan University, China

DNA for De Nova autoantigen: when DNA could trigger autoimmunity

Symposium (II): T Cell Response

Co-chairs: Yufang Shi (USA) and Xiaoming Gao (China)

8:00-8:25 Yufang Shi, University of Medicine and Dentistry of New Jersey, USA

Distinct pathways of activation-induced cell death in T-cell subsets

8:25-8:50 Xiaoming Gao, Peking University Health Science Center, China

Specificity and function of regulatory anti-T-cell Abs induced by T cell vaccination

8:50-9:15 Pan Zheng, University of Michigan, USA

Epm2a suppresses tumor growth in immune compromised host by inhibiting Wnt signalling

9:15-9:40 Dexian Zheng, Chinese Academy of Medical Sciences & Peking Union Medical College, China

Antibody gene therapy: an attractive approach for the treatment of cancers and other chronic diseases

9:40-10:05 Jianzhu Chen, Massachusetts Institute of Technology, USA

CD8+CTL response and memory against influenza

10:05-10:30 Coffee break

10:30-10:55 Bin Sun, Chinese Academy of Sciences, China

Trichosanthin is a novel Th2-type adjuvant and induces an allergic airway inflammation relied on a early IL-4 production during the immunization

10:55-11:20 Wanjun Chen, National Institutes of Health, USA

TGF-β and CD4+ CD25+ Foxp3+ Regulatory T Cells: Regulating the Regulator

11:20-11:45 Changyou Wu, Zhongshan University, China

Differentiation and memory phenotype of Th17 cells

Symposium (III): Infection and Immunity

Co-chairs: Hao Shen (USA) and Yuzhang Wu (China)

8:00-8:25 Hao Shen, U Penn School of Medicine, USA

Regulation of memory CD8 T cell differentiation

8:25-8:50 Yuzhang Wu, The Third Military Medical University, China

Function and phenotype of HBV-specific CTLs in chronic viral hepatitis B infection and intervention by mimogen in clinical trial

8:50-9:15 Suraj J Patel, Harvard-MIT Division of Health Science and Technology/The Center for Engineering in Medicine, USA

Gap Junctions Propagate TLR-independent dsDNA-induced Signals to Activate Antiviral Responses in Neighboring Cells

9:15-9:40 Wei He, Chinese Academy of Medical Sciences, China

The role ofγδ T cells in immunosurveillance

9:40-10:05 Min Wu, University of North Dakota School of Medicine and Health Sciences, USA

Cholesterol rich membrane rafts and Lyn are required for phagocytosis during infection

10:05-10:30 Coffee break

10:30-10:55 Hong Tang, Chinese Academy of Sciences, China

Adaptive immune cells temper initial innate responses

10:55-11:20 Jianxun Song, La Jolla Institute for Allergy & Immunology, USA

Synergy between molecular targets of costimulation in promoting persistence of CD8+ T cells

11:20-11:45 Angang Yang, Fourth Military Medical University，China

Targeted inhibition of HBV gene expression by single chain antibody-mediated siRNA delivery

11:45-12:10 Fusheng Wang, Beijing 302 Hospital, China

Both regulatory T cells and inhibitory receptors impair CD8+T cell responses in chronic HBV-infected or HBV-associated HCC patients

July 14, 2007 14:00-18:00 Workshops

1. Immunobiology of antigen-presenting cells

Co-chairs: Wenru Song (USA) and Hong Tang (China)

2. T cell activation and regulation

Co-chairs: Jianzhu Chen (USA) and Bin Sun (China)

3. Antibody: from basic to clinics

Co-chairs: Pan Zheng (USA) and Zhinan Chen (China)

4. Cytokines and chemokines in health and diseases

Co-chairs: Wan-Jun Chen (USA) and Renqian Zhong (China)

5. Autoimmune diseases and allergy

Co-chairs: Chen Dong (USA) and Zhanguo Li (China)

6. Transplantation immunology

Co-chairs: Xiaokang Li (Japan) and Zhiren Fu (China)

7. Infection and immunity

Co-chairs: Xiaoxia Li (USA) and Sidong Xiong (China)

8. Immunotherapy and vaccination

Co-chairs: Rong-Fu Wang (USA) and Zhi Yao (China)

July 15, 2007 8:00-12:30

Plenary session 5: Tumor Immunology

Co-chairs: Antonio Lanzavecchia (Switzerland) and Weifeng Chen (China)

8:00-8:25 Antonio Lanzavecchia, Institute for Research in Biomedicine, Switzerland)

TBD

8:25-8:50 Guido Kroemer, Institut Gustave Roussy, France

Ecto-calreticulin in immunogenic chemotherapy

8:50-9:15 Rong-Fu Wang, Baylor College of Medicine, USA

Regulatory T cells and their functional regulation by TLR signaling in cancer

9:15-9:40 Laurence Zitvogel, Institut Gustave Roussy, FRANCE

Toll-like receptor 4 -dependent contribution of the immune system to anticancer drugs

9:40-10:05 Yang Liu, University of Michigan, USA

Epithelia-intrinsic function of FoxP3 in cancer and autoimmune diseases

10:05-10:20 Coffee break

Plenary session 6: Immune Regulation

Co-chairs: Masyuki Miyasaka (Japan) and Boquan Jin (China)

10:20-10:45 Alan G. Baxter, James Cook University, Australia

Congenic analysis of the NKT cell control genes Nkt1 and Nkt2

10:45-11:10 Chen Dong, MD Anderson Cancer Center, USA

Regulation of inflammatory T cell differentiation

11:10-11:35 Zhigang Tian, University of Science and Technology of China, China

Interleukin-15 inhibits apoptosis of cord blood CD56dim natural killer cell subset by upregulation of Bcl-xL

11:35-12:00 Yang-Xin Fu, The University of Chicago, USA

The negative regulation of innate and adaptive cells in early infection

12:00-12:25 Li Wu, Walter and Eliza Hall Institute of Medical Research, Australia

The role of thymic dendritic cells in the development of naturally occurring T-regulatory cells

12:25-12:50 Masyuki Miyasaka, Osaka University, Japan

How do chemokines work in vivo?

July 15, 2007 12:50-13:00 Closing Remarks

GENERAL INFORMATION

CONFERENCE DATES AND VENUE

The Conference will be held July 12 to 15, 2007. Location is: Shanghai International Convention Center Shanghai International Convention Center, also known as the Oriental Riverside Hotel, is a 5-star Convention Hotel located in the heart of Lujia zui---Shanghai's Financial & Trade Zone. Address: 2727 Riverside Avenue Pudong, Shanghai, China 200120

LANGUAGE

The official language of the Conference is English. REGISTRATION FEES

The registration fee is as follows:

Before May 15, 2007 After May 15, 2007 Participant US$ 380 US$450 Accompanying person US$ 120 US$150 The registration fee includes conference bag, program and abstract book, lunch and coffee breaks during the conference, welcome reception, banquet and complimentary tour. Registration fee for accompanying persons: Welcome reception, banquet and complimentary tour. ABSTRACT DEADLINE: May 15, 2007 Participants wishing to submit an abstract should use the enclosed Abstract Form and e-mail it to [email protected] POSTER PRESENTATION The size of the poster board is 1m wide, 1.2m high. Some abstracts will be selected for oral presentation at workshop sessions. ABOUT SHANGHAI Shanghai, the largest city in China, attracts people at home and abroad like a magnet. People come here for its culture, its history, its people and all the vigor and vitality it shows in its rush to international metropolis status. Like a pearl set in the west coast of the Pacific Ocean, Shanghai is the showcase of China's fast growth and a bonanza of tourist attractions, business opportunities and cultural activities. Today's Shanghai is designed with the aim of letting more people all over the world have a better understanding of Shanghai, especially of its current developments. For more information: http://travel.yahoo.com/p-travelguide-191501624-shanghai_vacations-i COFFEE AND TEA The participants will be supplied with coffee and tea during breaks.

PASSPORT AND VISA A valid passport and visa for visiting China are required. Upon receiving your Registration Form and Fees, we will send you an official invitation letter with which you can apply for an entry visa at your local Chinese Embassy or Consulate general. Please send the Registration Form before May 15, 2007. WEATHER The weather in Shanghai in July is hot and rainy. The average daily temperature is about 28°C (82.4°F), with the high at around 32°C (89.6°F) and low at around 24°C (75.2°F). All meeting rooms are air conditioned. INSURANCE The Organization Committee cannot accept any liability for personal accidents or loss of or damage to the private property of participants, students and accompanying persons during the conference or indirectly arising from the conference. It is advisable that participants take out adequate travel and health insurance before leaving their own countries. ELECTRICITY The electricity is supplied at 220V, 50Hz in China. CURRENCY EXCHANGE In China, only RMB is used. However, exchange centers can be found at airports, most hotels and large shopping centers. When exchanging money, please keep your receipt by which you can change any remaining RMB back to foreign currency when leaving China. Visa, Master, American Express, Diners Club and JCB are accepted in many department stores and hotels. It may be difficult to draw cash with credit cards. The Bank of China and most hotels can cash travelers check issued by any foreign bank or financial institution. Participants will need to show a passport. Travelers' check signed over to a third party cannot be cashed in China, but can be presented for collection through the Bank of China. AIRPORT TO SHANGHAI INTERNATIONAL CONVENTION CENTER

Taxi service is available both days at Shanghai Pudong International Airport and Hongqiao Airport (domestic flights only). The cost from Pudong International Airport to Shanghai International Convention Center is about US$25, or RMB 200 Yuan. The cost form Hongqiao Airport to Shanghai International Convention Center is about $13, or RMB 100 Yuan. Please find the Taxi Note in this announcement to help you to the hotel and venue. RECONFIRMATION OF AIR TICKET Departure air ticket (both international and domestic) should be reconfirmed 72 hours in advance. Calling the airline office in Shanghai is possible, however these offices do not work on weekends.

ACCOMMODATIONS Shanghai International Convention Center (www.shicc.net), also known as the Oriental Riverside Hotel, is the first and the only hotel categorized as 5-star Convention Hotel in Pudong. Located in the heart of Lujia Zui---Shanghai's Financial & Trade Zone and southwest to the Oriental Pearl TV Tower, it is accessible from all parts of the city with various modern transportations. The hotel has 260 well-appointed guestrooms, a wide range of F&B outlets, comprehensive recreational facilities and meeting venues. With the capacity of 3000 persons, the Grand Ballroom on the 7th floor is the largest pillar-less ballroom in Shanghai. 25 additional meeting rooms are located on the 3rd and 5th floor with seating capacity from 25 up to 800 persons, equipped with the latest audio-visual facilities. Rooms Rates are as follows: Price Standard Twin USD 220 Superior Twin USD 250 A deposit of one night’s room rate is required for any reservation, with the balance being payable direct to the hotel on checkout. Reservations with deposit must be received. Later reservations may not be guaranteed.

Reservation of other hotels (about 40USD/day -60USD/day):

http://www.1rest.com/hosteltag/25/city0/p1/

http://www.868e.com/Hotel/Hotel_View_1502.Aspx

http://www.hotel525.com/hotel/1047.htm

http://www.chinahotel.com.cn/shanghai/hotelinfo.php?hotelid=143#roominfo

PAYMENT All fees must be paid in U.S. dollars by bank transfer. Currency exchange charges or bank collection fees are the money sender’s responsibility. By bank transfer to China Merchants Bank Shanghai Branch (account No.6085258832001), Shanghai, China. A duplicate of the transfer order from the bank should be sent with the Registration Form to the Secretariat. On-site payment should be made in US dollars in cash or traveler’s checks. Credit card will not be accepted. BEAUTIFUL CITIES AROUND SHANGHAI

Hangzhou

Suzhou

International Conference on Immunology 2007

ABSTRACT FORM

Please e-mail to Dr. Yanfeng Wu, [email protected]

International Conference on Immunology 2007

Shanghai, China July 12-15, 2007

ABSTRACT FORM

1. Format should be Title, Authors, and Institutions: followed by the abstract.

2. Enter the name of the first author, names of all other authors and institutions.

3. Your entire abstract must be typed within the space provided. Typing must be single spaced and

font size>12pts.

Abstract Title:

Authors:

Name of Presenting Author:

Address:

Telephone Number: FAX Number:

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Select your presentation preference

( ) this abstract could be selected ( ) please consider this abstract only for

for oral presentation poster presentation

International Conference on Immunology 2007

Shanghai, China July 12-15, 2007 (See more detailed information at our website: http://www.immunol.org)

Title 1Mr 1Ms 1Dr 1Pr Name: _____________________ First Name:________________________________ Accompanying person name:_____________________________________________ Telephone:________________________Fax:________________________________ Institution:____________________________________________________________ Address:_________________________________________________________________________________________________________________________________ City:_____________________Country_____________Post Code_______________ I am enclosing an abstract 1Yes 1No Abstract title__________________________________________________________ Presentation preference 1Oral presentation 1 Poster 1 Indifferent Registration Fees: Before May 15, 2007 After May 15, 2007 Participant US$ 380 US$450 Accompanying person US$ 120 US$150 Payment 1By check 1By bank transfer please check other information at our web-site Registration Fee_______ Signature_____________ Date_________________ Please return this form to: Dr. Yanfeng Wu Institute of Immunology Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China Phone: (+86-21)-5562 0605 Email: [email protected] Fax: (+86-21)-6538 2502 Web-site: www.immunol.org