Interferon-g-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever

Article Interferon-g-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever Graphical Abstract Highlights d LCMV-WE-infected HHD mice manifest characteristics of arenavirus hemorrhagic fever d LCMV-WE infection triggers a systemic inﬂammatory response, including iNOS-derived NO d iNOS is essential for LCMV-WE-induced terminal shock but not generalized inﬂammation d IFN-g blockade prevents iNOS induction and terminal disease in LCMV-infected HHD mice Authors Melissa M. Remy, Mehmet Sahin, Lukas Flatz, ..., Beat A. Kaufmann, Doron Merkler, Daniel D. Pinschewer Correspondence [email protected] In Brief Viral hemorrhagic fevers (VHF) are characterized by a cytokine storm, culminating in vascular leak and shock. In a model of arenavirus hemorrhagic fever, Remy et al. identify inducible nitric oxide synthase (iNOS) as a key mediator of VHF. Interferon-g blockade prevents iNOS induction, abrogating vascular leak and terminal shock. Remy et al., 2017, Cell Host & Microbe 22, 354–365 September 13, 2017 ª 2017 Elsevier Inc. http://dx.doi.org/10.1016/j.chom.2017.07.008

Interferon-g-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever

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