Insulin Actions and Receptors

• 1. Insulin Actions Receptorwww.medicinemcq.com

2. Main site of action of insulinLiver Also Muscle Adipose tissue 3. www.medicinemcq.com 4. www.medicinemcq.com 5. www.medicinemcq.com 6. www.medicinemcq.com 7. www.medicinemcq.com 8. www.medicinemcq.com 9. www.medicinemcq.com 10. www.medicinemcq.com 11. www.medicinemcq.com 12. www.medicinemcq.com 13. www.medicinemcq.com 14. www.medicinemcq.com 15. www.medicinemcq.com 16. Insulin actionsStimulates Glycogenesis Lipogenesis Protein synthesisInhibits Glycogenolysis Lipolysis Protein breakdown www.medicinemcq.com 17. Liver - insulin actionsDecreases glucose output Decreased gluconeogenesis Increased glycogen synthesisDecreases ketogenesis 18. Muscle Cells And Adipose Cells insulin actionsMarkedly increase uptake of glucose 19. Insulin receptorsPresent on virtually all cells High concentration Liver Muscle Adipose tissuewww.medicinemcq.com 20. Insulin ReceptorBelongs to tyrosine kinase class 21. www.medicinemcq.com 22. www.medicinemcq.com 23. www.medicinemcq.com 24. www.medicinemcq.com 25. www.medicinemcq.com 26. www.medicinemcq.com 27. www.medicinemcq.com 28. GLUT 4Glucose transporter Stimulated by insulinMuscle Adipose tissue 29. www.medicinemcq.com 30. Half LifeInsulin receptor 7 to 12 hoursInsulin 5 minutes 31. GLUT 4Two major insulin target tissues Skeletal muscle Adipose tissuewww.medicinemcq.com 32. www.medicinemcq.com 33. GLUT 4Sequestered mainly within an intracellular compartment Does not function as a glucose transporter until insulin signaling causes translocation of GLUT 4 to the cell membranewww.medicinemcq.com 34. Glucose disposal after a mealImportant sites of glucose disposal Skeletal muscle and adipose tissuewww.medicinemcq.com 35. Glucose disposal after a mealImportant sites of glucose disposal Skeletal muscle and adipose tissue GLUT4 Insulin-responsive www.medicinemcq.com 36. ExerciseMuscle Drives GLUT 4 translocation to the cell surface By activating MAPK.www.medicinemcq.com 37. Exercise increase insulin sensitivity of musclePersists for several hours after exercise Regular exercise Prolonged increase in insulin sensitivity 38. Decrease Insulin Receptors Per CellExposure to increased levels of insulin. Diabetes type 2 Obesity. Acromegaly. 39. InsulinSecreted only by pancreaswww.medicinemcq.com 40. Glucose > 70 mg/dLStimulate insulin synthesis and insulin secretion Food intake Insulin secretion stimulated 41. InsulinAnabolic Insulin helps in the storage of Carbohydrate Fats Proteins 42. Insulin Promotes Energy StorageConversion of substrates into Glycogen Triglycerides Proteins 43. Excess carbohydratesStored as glycogen Liver and muscles.Excess carbohydrates that cannot be stored as glycogen Converted into fatsStored in the adipose tissue.