Institutional Resources to Help With Research

Jeanne-Marie Guise, M.D., M.P.H.Director, Oregon BIRCWH and Comparative Effectiveness K12 Programs

Cynthia Morris, PhD, M.P.H.Director, OCTRI Education and Career Development Core

Darlene Kitterman, MBADirector, OCTRI Investigator Support and Integration Services

Rachel Dresbeck, Ph.D.Director, Research Development and Communication Services

October 2010

Institutional Resources to Help With Research

Predoctoral Individual NRSA (F31)Predoctoral Individual MD/PhD NRSA (F30)

T32: Postdoctoral Institutional Training Grant F32: Postdoctoral Individual NRSA

Small Grant (R03)

Research Project Grant (R01)

K02: Independent Scientist Award

K05: Senior Scientist Award

Fellowships & Career AwardsGRADUATE/

MEDICALSTUDENT

POST-DOCTORAL

FACULTY

Predoctoral Institutional Training Grant (T32)

K01: Mentored Research Scientist Development Award K08: Mentored Clinical Scientist Development Award K23: Mentored Patient-Oriented RCDA

K24: Midcareer Investigator Award in Patient-Oriented Research

Exploratory/Developmental

Grant (R21)

Training and Career Development Pathway

Trai

ning

Inde

pend

ent

Research Grants T

rans

ition

K99/R00: NIH Pathway to Independence (PI) AwardK22: NIAAA Career Transition Award

Research Center Grant (U and P series)

K Support• Salary Support

– Low (supplement clinically)– 75% time (50% for some specialties)– For training– For conducting research

• Research funding– Up to $25,000 per year for research and training

expenses (e.g. tuition, books, supplies)• Training is an expected part of Ks

– Must describe a training plan in the proposal

Institutional K vs. Independent K vs. R01

Independent K• Higher probability of

funding (vs. R01)• Your previous track

record can be slim• Limited research funding• Can get an R01 later• Requires NCR yearly

R01• More difficult to get

funding• Rating depends in part

on PI experience• No limit on research

funding• Cannot get a K later• Requires NCR yearly

Institutional K• Highest probability of

funding• Your previous track

record can be slim• Limited research

funding• Can get an independent

K or R01 later• Requires annual update

of information & competitive renewal after 2nd year

Institutional Ks• BIRCWH (Dorsa,Guise) – Building Interdisciplinary

Research Careers in Women’s Health (NICHD) Basic, Translational, Clinical, Behavioral 4 slots

• OCTRI KL2 (Morris)– Designed for Career Development in Translational Research 6 slots

• Child Health Research Center K12 ( Nicholson,Marks) 3 slots

• Comparative Effectiveness K12 (Guise,Morris) 4 slots

Independent Ks• K01: Mentored Research Scientist• K02: Independent Scientists Award• K08: Mentored Clinical Scientist• K22: Career Transition award

– Postdoctoral fellows in transition to a faculty position• K23: Mentored Patient Oriented Research Career

Development• K24: Mid Career Investigator Award in Patient Oriented

Research• K25: Mentored Quantitative Research Career Development• K99/R01 Pathway to Independence Award

– 1-2 years mentored 3 years independent (intended for postdocs)

CD 7

NUMBER OF ENTRY LEVEL RESEARCH CAREER AWARDS

0

250

500

750

1,000

1,250

1998 1999 2000 2001 2002 2003 2004 2005 2006 2007

K08 K23 K01 K25 K99

Fiscal Year

Num

ber o

f Aw

ards

CD 8

SELECT RESEARCH CAREER DEVELOPMENT AWARDSAPPLICATIONS, AWARDS, AND SUCCESS RATES

0%

20%

40%

60%

80%

100%

1998 1999 2000 2001 2002 2003 2004 2005 2006 2007

Fiscal Year

Succ

ess R

ate

K01 K02 K08 K23 K24

CD 9

NUMBER OF INDIVIDUAL RESEARCH CAREER AWARDS BY INSTITUTES AND CENTERS

20070

100

200

300

400

500

600

Fiscal Year

NIH Institutes and Centers

Num

ber o

f Aw

ards

199819992000200120022003200420052006

NCMHDNCCAMFICNIB

IBNLMNHGRINIG

MSNINR

NIEHSNCRRNEI

NIDCR

NIDCD

NIAAANIAM

SNIC

HDNIANIDA

NINDS

NIAIDNID

DKNCINIM

HNHLB

I

0

100

200

300

400

500

600

CD 10

K01 APPLICATIONS AND AWARDS BY PARTICIPATING INSTITUTES AND CENTERS

FY 2007

0

20

40

60

80

100

120

NIDDKNIMH NCI

NIANIDA

NHLBINIAMS

NINDSNICHD

NIAIDNINR

NCRRNIAAA

NIBIBNCCAM

NIEHSNIDCD

NIGMS FIC

Participating NIH Institutes and Centers

Num

ber o

f App

licati

ons/

Awar

ds

Applications Awards

CD 11

K08 APPLICATIONS AND AWARDSBY PARTICIPATING INSTITUTES AND CENTERS

FY 2007

0

25

50

75

100

125

NHLBINIAID NCI

NIDDKNINDS

NIAMSNIMH

NICHD NIANIDCR

NIGMSNIDA NEI

NIDCDNIAAA

NIBIBNIEHS

NCCAM

Participating NIH Institutes and Centers

Num

ber o

f App

licati

ons/

Awar

ds

Applications Awards

CD 12

K23 APPLICATIONS AND AWARDS BY PARTICIPATING INSTITUTES AND CENTERS

FY 2007

0

20

40

60

80

100

120

Participating NIH Institutes and Centers

Num

ber o

f App

licati

ons/

Awar

ds

Applications Awards

CD 13

K24 APPLICATIONS AND AWARDS BY PARTICIPATING INSTITUTES AND CENTERS

FY 2007

0

5

10

15

20

25

NIDDKNIMH

NHLBINICHD NCI

NIAID NIANIDA

NINDSNCRR

NIAMSNIAAA NEI

NCCAMNIDCD

NIDCRNINR

Participating NIH Institutes and Centers

Num

ber o

f App

licati

ons/

Awar

ds

Applications Awards

NICHD Independent K Award Success Rates 2005-2009

OCTRI Education and Career Development

Cynthia Morris, Director

Educational PlatformHealth ProfessionalStudents, PredoctoralStudents

Clinical andPostdoctoral Fellows

OHSU andKP faculty

Educational PlatformHIP Curriculum

HIP Symposium, Seminars

Master of Clinical Research

Certificate in Human Investigations

T32 OSLER program OCTRI KL2 program

Clinical Research Education at OHSU

Master of Clinical Research• Certificate program (2 years)• Focused education in informatics,

epidemiology, biostatistics, basic sciences• Mentored capstoneCertificate in Human Investigations• Required didactic coursework (2 years)• Mentored capstoneNon-degree• Attend courses in C/T research

Core Competencies• Identify major clinical or public health problems and

relevant research questions.• Identify, interpret, and critique the state of knowledge

regarding a question.• Design and write a research proposal.• Identify appropriate study methods (study design) for a

research question considering feasibility, efficiency, and bias-free inference.

• Evaluate the reliability and validity of measures.• Use appropriate sample size, power and apply basic

statistical principles.

Core Competencies, continued• Employ effective information management. • Identify, evaluate, and minimize risks to research

subjects.• Effectively communicate orally and in writing with

colleagues and the public.• Work effectively with the diverse community.• Work effectively within a multidisciplinary research

team.• Manage a research project (personnel, budget)

HIP Capstone

• This mentored project pairs one or more mentors with trainee

• End product: NIH R01 or K grant (or equivalent) • End product: Manuscript suitable for

publication. Trainee must have designed project, implemented study, directed or conducted statistical analysis, written manuscript

HIP Buffet

• An informal forum to lean about practical topics for research

• Alternate Tues/Weds at noon• Examples:

– Developing a research budget– Finding funding for your study– Time management– Organizing your references– Creating a publication strategy

OCTRI SCHOLARS PROGRAMWho can participate?

• Anyone at OHSU or VA who is applying for a career development award or first R01.– “Temporary OCTRI Scholar” status during

application • Anyone at OHSU or VA who receives a career

development award or first R01• This includes VA CDA, NIH K awards, and

lookalike career development awards

OCTRI SCHOLARS: What is available?

• Educational program• Support of the scholar through

supplemental mentoring activities. – An informal, monthly noon seminar– A smaller, intensive group who commit to meet

biweekly for manuscript and grant development

• Support of career development award research through research support. – Talk with research navigator

• Support to maximize odds of research success – OCTRI Design Studio– Career Development Award (CDA) Library– Targeted information dissemination via listserv on funding

opportunities, seminars and conference

• Support to improve mentoring quality– Participation in an electronic "learning community" for mentors

and mentees– Participation in OHSU institutional programs that deliver

workshops and seminars targeted to mentors and mentees.

OCTRI SCHOLARS: What is available?

Grow from Within to ExcellenceA Mentoring Initiative

• Lead Mentor Program (cohort of 15-18)– Take responsibility for developing mentoring

programs within dept or organization. – Mentors share best practices, learn new strategies

• Career & Mentoring Series– Seminars and workshops on mentoring

• Work-life balance; Coaching through active listening; Mentoring across differences

• Mentoring website (www.ohsu.edu/mentoring)

OHSU Clinical & Translational Research Resources

Darlene KittermanProgram Director, OCTRI Investigator Support & Integration Services (ISIS)

Accessing OHSU Research Resources

• Women’s Health Research Unit (WHRU): Single point of contact to coordinate resources for ob/gyn students and faculty.– Access to WHRU departmental research resources– Triage to OHSU institutional research resources

• Oregon Clinical & Translational Research Institute (OCTRI)• Institutional core resources• Navigate research administration

– Assist investigators in finding collaborators• Contact

– Tracy Lawson, WHRU Administrative Manager– 4-0111– [email protected]

OCTRI Research Navigator Program• Gateway to OCTRI Resources: Single point-of-contact for OCTRI services• Facilitates access to OCTRI and Kaiser Permanente resources:

– Resource availability and suitability for the research– Resource costs– OCTRI scientific review process, when applicable

• Studies using more than one OCTRI program and;• The study has not received scientific review (Knight Institute, NIH, FDA) or a career development award

– OCTRI support for new investigators: some services may be free or subsidized– OCTRI letters of support

• Assists investigators in finding collaborators at OHSU and Kaiser Permanente• Contacts

– Navigator Service staff• Navigation Manager: Joanne Price• Navigation assistants: Sunitha Jagannathan and Cynthia Malain

– Call 503-418-9790 or email [email protected]

OHSU resources for all stages of translational research

Design and planning

Funding application

Pre-study and start-up

Carrying out the research

Analysis and publications

Design and Planning

• Finding collaborators– Ob/gyn, OHSU & Kaiser Permanente

• Statistical support– Design– Sample calculations– OCTRI free Drop-in sessions: Wednesdays, 4-5pm, HRC14D80

• Patient population feasibility– OCTRI virtual data warehouses (OHSU & KP)– ResearchMatch.org: Julie Mitchell, OCTRI BMIP

• Guidance in community and practice-based research

Design and

planning

Funding applicatio

n

Pre-study and start-

up

Carrying out the

research

Analysis and publications

Funding Application

• Statistical support• Grant development

– Writing/editing– Budget development (grant and industry)

• Regulatory assistance– Human subject regulation guidance– IND/IDE requirements guidance– Data & Safety Monitoring Plan development

Design and

planning

Funding applicatio

n

Pre-study and start-

up

Carrying out the

research

Analysis and publications

Pre-study & Start-Up

• Compliance submission services– Protocol development– IRB submissions (OHSU, KPCHR, VA)– IND/IDE submissions to FDA

• OCTRI informatics solutions:– Database development:

• REDCap: Free basic access– Database: online, webbased data forms and database– Survey: Sophisticated online, webbased survey tool

• Free REDCap Tutorials: 1st Tuesday/3rd Monday, 2-4pm, HRC10D03– Scannable forms– Virtual Data Warehouse: Data from Epic (OHSU & Kaiser)

Design and

planning

Funding applicatio

n

Pre-study and start-

up

Carrying out the

research

Analysis and publications

Implementation Stage

• Research space– OCTRI CTRC inpatient (MPV2SE)– Outpatient

• WHRU MPV• OCTRI CTRC: HRC & CHH

• Research nursing services• Study coordinator pool• OCTRI bionutrition services

– Dietitian consultations– Patient meals and snacks

• Energy expenditure and body composition procedures

• OCTRI core laboratory services– Assays– Sample processing and shipping– Genetic analyses

Design and

planning

Funding applicatio

n

Pre-study and start-

up

Carrying out the

research

Analysis and publications

• Limited OCTRI funding to support costs of OHSU hospital tests and pharmacy services

• Regulatory services– IND/IDE annual updates to FDA– GCP monitoring for IND/IDEs

• Data & Safety Monitoring Board coordination

• OCTRI Biolibrary (OHSU & KP)– Sample access– Sample banking

Analysis & Publication

• Statistical services– Data analysis– Manuscript preparation

Design and

planning

Funding applicatio

n

Pre-study and start-

up

Carrying out the

research

Analysis and publications

Resources for Funding at OHSURachel Dresbeck, Ph.D.

Research Funding & Development Services

Funding landscape at OHSU

OHSU researchers brought in $392 million in FY 2010

Research Funding & Development Services

Rachel Dresbeck, Ph.D.Director

Currently HiringProgram Manager

Katie WilkesAdministrative Coordinator

Contact us: [email protected]

Research Funding & Development Services

RFDS

Grant Funding

Proposal Development

Research Communicati

ons

Grant Funding

• Funding Database• Weekly Funding Alerts• Limited Submission Program• Presidential Bridge Funding• Internal funding opportunities• Visit the funding portal on our website!

– http://www.ohsu.edu/xd/research/administration/research-funding-development/

Proposal Development

• Help with grant writing• Workshops

– Specific Aims Workshop– NIH Format Change Workshop

• Funding Focus and other forums– Sample topics: Grant Writing 101, Foundation

Funding, NIH Public Access Policy, and more!• Vollum Writing Class

Research Communications

• Research News blog• Email updates

Where to get help

Research Funding and Development Serviceswww.ohsu.edu/xd/research/administration/research-funding-development/index.cfm

Email us: [email protected]

Research Development & Administrationwww.ohsu.edu/xd/research/administration/index.cfm