Molecular characterization of new Homologous Recombination factors during DNA replication stress Growing evidence suggests that replicative stress-induced genomic instability underlies the cancer predisposition in individuals with sporadic or hereditary mutations in specific Homologous Recombination (HR) and Fanconi Anemia (FA) genes, besides their well-established role in Double- Strand Break (DSB) and interstrand- crosslink (ICL) repair. The student will join a group of 10 researchers and – under the direct supervision of a postdoc - will focus on investigating the molecular role in replication stress of new HR factors, recently identified by a high-content microscopy-based genetic screen. The student will learn and perform independently a number of different approaches, ranging from standard molecular and cell biology methods to more specialized techniques such as Quantitative Imaging-based Microscopy (QIBC), in vivo DNA labelling and chromosome spreading, and Electron Microscopy of replication intermediates. Institute of Molecular Cancer Research 24h Cdc25A Application: [email protected] Send brief motivation letter + CV Starting date: September 2016 Duration: 12 months www.imcr.uzh.ch MSc/Diploma position DNA Replication and Genome Instability Group Prof. Massimo Lopes