INFORMAZIONI PERSONALI Donato Luigi - Unime Donato_Giacobello_Lombardo... · INFORMAZIONI PERSONALI Donato Luigi 090-9762246 (+39) 320-0698332 [email protected] ... Biochimica, Microbiologia
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2016–alla data attuale RicercatoreIstituto Euro-Mediterraneo di Scienza e Tecnologia (I.E.ME.S.T.)Via Michele Miraglia/Piazzetta Briuccia, 20, 90139, Palermo, Italia Palermo (Italia) www.iemest.eu
Attività o settore Biologia e Genetica
01/2014–alla data attuale BiologoLaboratori di Genetica e Biologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali, Università degli Studi di Messina, Messina (Italia)
Attività di Ricerca e Diagnostica di tipo genetico – molecolare relativa a patologie tra cui:
▪ Angiomi Cavernosi
▪ Tumori al seno
▪ Retinite pigmentosa
▪ Trimetilaminuria
2013–alla data attuale BiologoLaboratori di Genetica e Biologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali, Università degli Studi di Messina, Messina (Italia)
Attività seminariale didattico – interattiva nei CdS in Biotecnologie, Biotecnologie per la Salute, Medicina e Chirurgia
2014–alla data attuale BiologoLaboratori di Genetica e Biologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali, Università degli Studi di Messina, Messina (Italia)
Attività di orientamento e tutorato inerente PON "Alternanza scuola – lavoro" in collaborazione con l'Istituto Superiore "G. Minutoli" di Messina
07/2015–alla data attuale BiologoE.R.S.U. MessinaVia Ghibellina, n°146, Messina (Italia) www.ersu.me.it
Docente di Biologia nel "CORSO DI PREPARAZIONE AL SUPERAMENTO DEI TEST UNIVERSITARI DI INGRESSO AI CORSI DI LAUREA AD ACCESSO PROGRAMMATO A LIVELLONAZIONALE" – E. R. S. U. Messina
▪ Determinazione dei gruppi sanguigni e relativo fattore Rh
▪ Batteriologia (allestimento terreni di coltura, colorazione di Gram, antibiogramma ed antimicogramma)
Attività o settore Sanità e assistenza sociale
ISTRUZIONE E FORMAZIONE
2016 Bioinformatic Methods II Grade Achieved:100.0%
University of Toronto on Coursera.org, Toronto (Canada)
Large-scale biology projects such as the sequencing of the human genome and gene expression surveys using RNA-seq, microarrays and other technologies have created a wealth of data for biologists. However, the challenge facing scientists is analyzing and even accessing these data to extract useful information pertaining to the system being studied. This course focuses on employing existing bioinformatic resources – mainly web-based programs and databases – to access the wealth of data to answer questions relevant to the average biologist, and is highly hands-on.
▪ Topics covered include multiple sequence alignments, phylogenetics, gene expression data analysis, and protein interaction networks, in two separate parts.
▪ This, the second part, Bioinformatic Methods II, will cover motif searching, protein-protein interactions, structural bioinformatics, gene expression data analysis, and cis-element predictions.
2016 Bioinformatic Methods I Grade Achieved:100.0%
University of Toronto on Coursera.org, Toronto (Canada)
Large-scale biology projects such as the sequencing of the human genome and gene expression surveys using RNA-seq, microarrays and other technologies have created a wealth of data for biologists. However, the challenge facing scientists is analyzing and even accessing these data to extract useful information pertaining to the system being studied. This course focuses on employing existing bioinformatic resources – mainly web-based programs and databases – to access the wealth of data to answer questions relevant to the average biologist, and is highly hands-on.
▪ Topics covered include multiple sequence alignments, phylogenetics, gene expression data analysis, and protein interaction networks, in two separate parts.
▪ The first part, Bioinformatic Methods I (this one), deals with databases, Blast, multiple sequence alignments, phylogenetics, selection analysis and metagenomics.
10/2015–alla data attuale Dottorato di ricerca in Biologia Applicata e Medicina Sperimentale – XXXI CicloUniversità degli Studi di Messina, Messina (Italia)
Competenze specialistiche ed innovative sull'applicazione della Biologia alla Medicina Sperimentale
10/2012–01/2013 Abilitazione alla professione di Biologo Senior Votazione 200/200
Università degli Studi di Messina, Messina (Italia)
Biologia e Deontologia Professionale
03/2013–07/2013 Attestato di conseguimento esame Trinity – livello 10, C1 of the Common European FrameworkTrinity – The International Examinations Board
Conoscenza della lingua inglese parlata e scritta: Speaking, Listening, Writing, Reading
10/2010–10/2012 Laurea Magistrale in Biologia (D. M. 270/04) – indirizzo BIOSANITARIO
Votazione 110/110 eLode
Università degli Studi di Messina, Messina (Italia)
Tesi:
▪ "Localizzazione di glicosamminoglicani ed ossido nitrico sintasi nelle cellule dell'encefalo di Maena osbechii Cuvier e Valenciennes 1830"
Settore generale
▪ Competenze avanzate in Fisiologia Animale e Vegetale, Biochimica, Microbiologia Molecolare, Fisiopatologia Cellulare, Farmacologia, Anatomia Umana ed Igiene
Settore professionale
▪ Allestimento di preparati per la microscopia ottica ed elettronica, colorazioni citoistomorfologiche edimmunocitoistochimiche per la localizzazione di macromolecole biologiche
▪ Conoscenza dei laboratori di ricerca universitari e del loro contesto economico, giuridico e sociale
03/2011–05/2011 European Computer Driving Licence (ECDL) COREAICA – Test Center ECDL presso Liceo Scientifico Statale “E. Medi”Via San Vito, n°76, 98051 Barcellona Pozzo di Gotto (ME) (Italia)
Competenze informatiche inerenti Hardware, Sistemi Operativi, Pacchetto Office (Word, Excel, Powerpoint, Access), Gestione Reti, Posta Elettronica ed Internet
10/2005–06/2010 Laurea Triennale in Scienze Biologiche (D. M. 509/99) – indirizzo BIOSANITARIO
Votazione 110/110
Università degli Studi di Messina, Messina (Italia)
Tesi
▪ "Evoluzione e studio comparativo dell'occhio dei Vertebrati"
Altre lingue COMPRENSIONE PARLATO PRODUZIONE SCRITTA
Ascolto Lettura Interazione Produzione orale
inglese C1 C1 C1 C1 C1
Certificato conseguimento esame Trinity – livello 10, C1 of the Common European Framework
Livelli: A1 e A2: Utente base - B1 e B2: Utente autonomo - C1 e C2: Utente avanzatoQuadro Comune Europeo di Riferimento delle Lingue
Competenze comunicative Buoni spirito di gruppo e capacità di comunicazione acquisiti durante la formazione ed il tempo libero, oltre a concrete capacità di adattamento ad ambienti multiculturali conseguite durante la formazione
Competenze organizzative egestionali
Ottimo senso dell'organizzazione sviluppato durante la formazione (gestione di progetti letterari e scientifici)
Competenze professionali 1. Organizzazione e manutenzione di un laboratorio scientifico
2. Allestimento di preparati per la microscopia ottica
3. Analisi citoistochimiche ed immunoistochimiche
4. Esame completo delle urine (esame chimico – fisico ed esame del sedimento)
Pubblicazioni e Lavori in extenso(Internazionali con Referee)
▪ Balestri, M., Crisafulli, C., Donato, L., Giegling, I., Calati, R., Antypa, N., . . . Rujescu, D. (2017). Nine differentially expressed genes from a post mortem study and their association with suicidal status in a sample of suicide completers, attempters and controls. J Psychiatr Res, 91, 98-104. doi:10.1016/j.jpsychires.2017.03.009
▪ Donato, L., Bramanti, P., Scimone, C., Calamuneri, A., D'Angelo, R., Sidoti, A. (2017). A complex phenotypic pattern of unknown form of Retinitis pigmentosa: next-generation sequencing and discovering of 6 new candidate genes. American Journal of Human Genetics. (SUBMITTED)
▪ Donato, L. Novel intronic variants in unconventional gene cluster could lead to Retinitis pigmentosa phenotype. EMBJ. (ACCEPTED on March 2, 2017)
▪ Donato, L., Scimone, C., D'Angelo, R., Sidoti, A. (2017). Predictive and personalized approaches towards retinitis pigmentosa and cerebral cavernous malformations. Life SafetyAnd Security. doi: 10.12882/2283-7604.2017.5.2
▪ Donato, L., Scimone, C., Rinaldi, C., Briuglia, S., D'Ascola, A., D'Angelo, R., Sidoti, A. (2017). The combination of two variants in Elovl4 gene promoter strongly reduces the level of protein in a patient showing Stargardt Type 3 phenotype. PLoS One. (SUBMITTED)
▪ Donato, L., Scimone, C., Rinaldi, C., Aragona, P., Robledo, R., Sidoti, A., D'Angelo, R. (2017). Association of three polymorphisms in RP1 hotspot region in Sicilian patients with Retinitispigmentosa: preliminary data.Int J Mol Med. (SUBMITTED)
▪ Donato, L., Scimone, C., Nicocia, G., Valenti, A., Sidoti, A., D'Angelo, R. (2017). GLO1 gene polymorphisms and their association with retinitis pigmentosa: a case-control study in a Sicilian population.Int J Mol Sci. (SUBMITTED)
▪ Rinaldi, C., Bramanti, P., Scimone, C., Donato, L., Alafaci, C., D'Angelo, R., Sidoti, A. (2017). CCM genes polymorphisms and their potential relevance for sporadic cerebral cavernous malformation clinical management. J Neurol Sci. (ACCEPTED in January, 2017)
▪ D'Angelo, R., Donato, L., Venza, I., Scimone, C., Aragona, P., Sidoti, A., (2017). Possible protective role in Stargardt disease and syndromic retinitis pigmentosa of the ABCA4 gene c.1268A>G missense variant in a Sicilian family: preliminary data. Int J Mol Med. (ACCEPTED on November 23, 2016)
▪ Scimone, C., Bramanti, P., Alafaci, C., Granata, F., Piva, F., Rinaldi, C., Donato, L., Greco, F., Sidoti,A. and D'Angelo, R. (2016). Update on Novel CCM Gene Mutations in Patients with Cerebral Cavernous Malformations. J Mol Neurosci. doi:10.1007/s12031-016-0863-z
▪ Scimone, C., Donato, L., Rinaldi, C., Sidoti, A., & D'Angelo, R. (2016). First case of Currarino Syndrome and Trimethylaminuria: two rare diseases for a complex clinical presentation. J Dig Dis. 2016 Sep;17(9):628-632. doi: 10.1111/1751-2980.12373
▪ Stefano, P., Concetta, C., Luigi, D., Marco, C., Antonis, P., Ioannis, L., . . . Alessandro, S. (2016). Role of neurodevelopment involved genes in psychiatric comorbidities and modulation of inflammatory processes in Alzheimer's disease. J Neurol Sci, 370, 162-166. doi:10.1016/j.jns.2016.09.053
▪ Scimone, C., Bramanti, P., Ruggeri, A., Donato, L., Alafaci, C., Crisafulli, C., . . D'Angelo, R. (2016). CCM3/SERPINI1 bidirectional promoter variants in patients with cerebral cavernous malformations: a molecular and functional study.BMC Med Genet, 17(1), 74. doi:10.1186/s12881-016-0332-0
▪ Scimone, C., Bramanti, P., Ruggeri, A., Katsarou, Z., Donato, L., Sidoti, A., & D'Angelo, R. (2015). Detection of Novel Mutation in Ccm3 Causes Familial Cerebral Cavernous Malformations. JMol Neurosci, 57(3), 400-403. doi:10.1007/s12031-015-0606-6
D'Angelo R., Sidoti A., Glyoxalase I A111E, Paraoxonase 1 Q192R and L55M Polymorphisms in Italian sporadic patients with cerebral cavernous malformations: a case – control study, JBiol Regul Homeost Agents. 2015 Apr-Jun;29(2):493-500
▪ Rosalia D'Angelo, Carmela Rinaldi, Luigi Donato, Giacomo Nicocia, Antonina Sidoti, The combination of new missense mutation with [A(TA)7TAA] dinucleotide repeat in UGT1A1 gene promoter causes Gilbert's syndrome, Ann Clin Lab Sci. 2015 Spring;45(2):202-5
Comunicazioni a Congresso ▪ L. Donato, C. Scimone, D'Angelo, A. Sidoti, NGS technologies: a valid approach to Retinitis pigmentosa genetic forms classification, Smart Science 2017, Catania, Italia, 26-27 Gennaio 2017 (Comunicazione Orale)
▪ C. Scimone, L. Donato, C. Rinaldi, D'Angelo, A. Sidoti, Possible role of oxidative stress in retinitis pigmentosa: a gene expression study. Human Genome Meeting (HGM 2017), Barcelona, Spain, 5-7 February 2017 (Poster)
▪ Balestri M, Crisafulli C, Donato L, Giegling I, Calati R, Antypa N, Schneider B, Marusic D, Tarozzi ME, Paragi M, Hartmann AM, Konte B, Marsano A, Serretti A, Rujescu D, Nine differentially expressed genes from a post mortem study and their association with suicidal status in a sample ofsuicide completers, attempters and controls. 29th ECNP Congress, Vienna, Austria, 17-20 September 2016 (Presentation Abstract).
▪ L. Donato, C. Scimone, C. Rinaldi, F. Greco, R. D'Angelo, A. Sidoti, Retinitis pigmentosa: a NGS approach towards personalized medicine, AIBG (Associazione Italiana di Biologia e Genetica Generale e Molecolare) 2016, Cagliari, Italia (Presentation Abstract)
▪ Scimone C., Donato L., Greco F., Rinaldi C., D'Angelo R., Sidoti A., CCM genetic test: Can some CCM genes SNPs in a homozygous condition be causative of Cerebral Cavernous Malformations?, 2° Neurological Disorders Summit, September 7-9, 2016, Baltimore (MD), USA (Presentation Abstract)
▪ Scimone C., Alafaci C., Ruggeri A., Donato L., Rinaldi C., D'angelo R., Sidoti A., Can loss of heterozygosity explain cerebral cavernous malformations' development in patients with no ccm genes germline mutations?, XVI Congress SINS, October 8-11, 2015 Cagliari, Italia (Poster)
▪ Donato L., Rinaldi C., Ruggeri A., Velardi E., Scimone C., D'Angelo R., Sidoti A., RP1 gene polymorphisms in a Retinitis pigmentosa patient affected by Congenital adrenal hyperplasia: a genotype - phenotype correlation, ESHG Conference, June 6-9, 2015 Glasgow, Scotland, UK (Presentation Abstract)
▪ Scimone C., Rinaldi C., Nicocia G., Greco F., Donato L., D'Angelo R., Sidoti A., A rare case of TMAU associated with suspected Currarino triad, ESHG Conference, June 6-9, 2015 Glasgow, Scotland, UK (Presentation Abstract)
▪ Donato L., Rinaldi C., Ruggeri A., Greco F., Scimone C., D'Angelo R., Sidoti A., RP1 gene polymorphisms and Retinitis pigmentosa: a possible genotype – phenotype correlation?, International Conference on Eye Disorders and Treatment, July 13-15, 2015 Baltimore, Maryland, USA (Poster)
▪ Donato L., Scimone C., Ruggeri A., Greco F., Rinaldi C., D'Angelo R., Sidoti A., Stargardt disease: a late – onset case study, International Conference on Eye Disorders and Treatment, July 13-15, 2015 Baltimore, Maryland, USA (Poster)
▪ C. Scimone, C.Rinaldi, A.Ruggeri, L.Donato ,R.D'Angelo, A.Sidoti, Two non-homologous co-regulated genes PDCD10 and SERPINI1: any possible related function?, AIBG (Associazione Italiana di Biologia e Genetica Generale e Molecolare) 2014, Napoli, Italia
Seminari et. al ▪ Partecipazione al Meeting SIBBM "From Genomes to Functions" 2016, From Single Cell Analysis to Precision Medicine, Napoli, Italia, 16-18 Giugno 2016
▪ Dalla PCR alla Next Generation Sequencing, Diatech Labline, 29 gennaio 2015, Messina, Italia
▪ Advance in Genome Science, Illumina Clinical, Genetic Disease and Microbiology Seminar, 29 ottobre 2014, Catania, Italia
MOOC (Massive Open OnlineCourses) ▪ Da settembre 2013 ad ottobre 2013. Statement of Accomplishment – Online Course about
"Genetics and Society: A Course for Educators". An overview of the science of genetics and genomics, the science and ethics of cloning, the science and ethics of gene therapy, the science
and ethics of genetically modified organisms (GMOs), learning how to talk to students about genetics and society American Museum of Natural History, tramite Coursera.org
▪ Da agosto 2013 a settembre 2013. Statement of Accomplishment – Online Course about "Preparation for Introductory Biology: DNA to Organisms". Parts of a cell and its membrane, polarity, charge and water, membrane transport, rearranging, biological macromolecules and their chemistry, manufacturing and transporting of proteins. University of California (Irvine), tramite Coursera.org
▪ Da aprile 2013 a luglio 2013. Statement of Accomplishment – Online Course about "Drug Discovery, Development & Commercialization". Pharmaceutical & Biotechnology Industry Landscape, Drug Discovery: Proteomics & Genomics, Compound selection & Preclinical Studies, Challanges in fragment based drug discovery to protein kinases, Key concepts in drug delivery, Regulatory considerations when filing an investigational new drug application, Clinical studies & Start up activities, Clinical trials: Phase I-III, New drug application, Pharmaeconomics in drug development, intellectual property strategy & Biosimilars, Marketing pharmaceuticals & Biotechnology drugs, Managed markets and sales strategy, Academic industry partnership, From start up to success in biotech, Drug discovery: targets & tools. University of California (San Diego), tramite Coursera.org
▪ Da luglio 2013 a settembre 2013. Statement of Accomplishment – Online Course about "Programmed Cell Death". Introduction to programmed cell death and apoptosis, the BCL-2 family of proteins, Apaf proteins, caspases, mechanisms that regulate apoptosis, non – apoptotic functions of components of the central apoptosis machinary, diseases caused by deregulated apoptosis. Ludwig – Maximilians – Universitat Munchen, tramite Coursera.org
▪ Da luglio 2013 ad agosto 2013. Statement of Accomplishment – Online Course about "Epigenetic Control of Gene Expression". Epigenetic modifications and their function in regulating gene expression and chromosome structure, epigenetic phenomena in lower organism, Mammalian epigenetics, epigenetic deregulation in disease, epigenetic and the environment (diet, maternal environment, maternal care). The University of Melbourne, tramite Coursera.org
▪ Da giugno 2013 ad agosto 2013. Statement of Accomplishment – Online Course about "Nutrition for Health Promotion and Disease Prevention". Introduction to nutrition science, heart diseases, diabetes, cancer, obesity and weight management, disorders of the GI tract. University of California (San Francisco), tramite Coursera.org
▪ Da giugno 2013 a luglio 2013. Statement of Accomplishment – Online Course about "Introduction to System Biology". Systems level reasoning, cell signaling pathways, signal flow, the actin cytoskeleton, mathematical representation of cell biological systems time and space, gathering large data sets in genomics and proteomics, infering modules, small scale systems biology experiments, dynamical models, ultrasensitivity, biostability, robustness and fragility, control systems, module – boundaries, emergence of cellular functions from subcellular modules, systemsanalysis of complex diseases, systems pharmacology. Icahn School of Medicine at Mount Sinai (Manhattan, New York), tramite Coursera.org
▪ Da maggio 2013 a luglio 2013. Statement of Accomplishment – Online Course about "Social Epidemiology". Background and history, issues, health disparities, theories and constructs, measurements, design and inference, interventions. University of Minnesota, tramite Coursera.org
▪ Da maggio 2013 a luglio 2013. Statement of Accomplishment – Online Course about "Useful Genetics". Introduction to DNA and genes, how DNA molecules change, DNA differences and gene functions, predicting the effects of genetic differences, personal genomics, the mechanics of inheritance, inheritance of genetic characteristics, linkage and paternity, hereditability, mitochondrialgenes and mutations, genetic mosaicism, fetal DNA in mothers, epigenetic inheritance. The University of British Columbia, tramite Coursera.org
▪ Da maggio 2013 a giugno 2013. Statement of Accomplishment – Online Course about "Nutrition, Health, and Lifestyle: Issues and Insights". What is a healthy diet, nutrition labeling, dietary supplements, functional and "super" foods, plant – based nutrition, nutrition and fitness. Vanderbilt University (Nashville, Tenn.), tramite Coursera.org
▪ Da aprile 2013 a giugno 2013. Statement of Accomplishment – Online Course about "Genes and the Human Condition (From Behavior to Biotechnology)". An introduction to genetics and learning the Lingo, comparative genomics, an examination of the role of genes in behavior, beyondthe genes: nature via nurture and epigenetics, an introduction to genetic engineering and learning the lingo, biotechnology. University of Maryland, tramite Coursera.org
▪ Da marzo 2013 a giugno 2013. Statement of Accomplishment – Online Course about "Synapses, Neurons and Brains". Brain excitements for the 21st century, the materialistic mind –your brain's ingredients, electrifying brains – active and passive electrical signals, neurons as plastic dynamic devices, cable theory and dendritic computations, cortical networks – out of the
Blue Brain Project; perception, action, cognition, emotions, from synapses to free will?. The Hebrew University of Jerusalem, tramite Coursera.org
▪ Da febbraio 2013 a maggio 2013. Statement of Accomplishment – Online Course about"AIDS". History of AIDS, Effects on the immune system, behavioral prevention, biomedicalprevention, vulnerable populations, clinical case issues, AIDS vaccines, future challenges,responding to HIV/AIDS. Emory University (Atlanta, Georgia), tramite Coursera.org