Influenza Activity and Virus Characterizations (Northern Hemisphere) 5thMeeting of NICs in the WPR and SEAR 7-10 June, 2011 Laos Takato Odagiri WHO Collaborating Center for References and Research on Influenza, National Institute of Infectious Diseases, Tokyo, Japan
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Influenza Activity and Virus Characterizations (Northern Hemisphere) 5thMeeting of NICs in the WPR and SEAR 7-10 June, 2011 Laos Takato Odagiri WHO Collaborating.
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Influenza Activity and Virus Characterizations (Northern Hemisphere)
5thMeeting of NICs in the WPR and SEAR 7-10 June, 2011 Laos
Takato Odagiri
WHO Collaborating Center for References and Research on Influenza,
National Institute of Infectious Diseases, Tokyo, Japan
Influenza subtypes 2010- 2011: Northern Hemisphere (as of May 23,2011)
B
H1N1pdm09
H3N2
WHO, FluNet
B
A(H1N1)pdm09
Former seasonal A(H1N1) 6 viruses (China, Malaysia, Russia, Tunisia, USA)A(H3)
A (not subtyped)
A(H5N1), 14 viruses- Cambodia (1) : CL 1 - Hong Kong (1) : CL2.3.2- Egypt (10) : CL 2.2.1 - Indonesia (2) : CL 2.1.2
Percentage of influenza viruses by subtypes(From 29 August 2010 – 29 January 2011)
31%
27%21%
21%
WHO, FluNet
54% 32% 14%
98% 2%
0%
Antigenic and genetic characterizations
A(H1N1)pdm09 viruses
Antigenic analysis of A (H1N1)pdm09 viruses by HI testsMar –Aug, 2010
JPN, China, Taiwan,Korea, Mongol, Laos,
Myanmar, Singapore
N+C America,EU, Asia, Africa, AU, NZ
NIID CDC
=4-fold low >8-fold low2% 1%
Sept, 2010 –Feb, 2011
A/Cal-likeA/Cal-like
=4-fold low 1%
99%
A/Cal-like
94%
=4-fold low 6%
A/Cal-like
89%
=4-fold low
9%
>8-fold low2%
95%
A/Cal-like
83%
>8-fold low
2%
A/Cal-like99%
NIMR
EU, Africa
>8-fold low1%
A/Cal-like
100%
C-CDC
China
>8-fold low2%
A/Cal-like
98%
Antigenic cartography of A(H1N1)pdm09 isolates
(Cambridge University)
Antigenic cartography of A(H1N1)pdm09 isolates
(Cambridge University)
Vast majority of A(H1N1)pdm09 viruses remained antigenically homologous to the A/California/07/2009 vaccine virus.
A/California/07/2009
Amino acid substitutions in H1N1pdm-HA protein that result in antigenic change from
A/Cal/7/2009
Position 155G to E
Position 156N to D
Position 157S to L
Colin, Derek et al, Cambridge U.
外
2010/11 Early phase(2010. Sept to 2011. Jan)
2009/10 late phase(2010, April to July)
Majority clade
Vaccine strain
Vaccine strain
3
12
526712321
1
1
25
1111
612
21
1
275Y 1.9% (53/2761)275H/Y 0.3% (8/2761)
China -CDCNIID
Detection of Antiviral resistant H1N1pdm09 viruses with 275Y substitution
December 2010 in BlueJanuary 2011 in GreenFebruary 2011 in OrangeMarch 2011 in Pink#: Fatal case@: Oseltamivir resistanceLow: Low HA
OITA/77/2011 FEB Low @ OITA/72/2011 FEB G155E/G @ HOKKAIDO/32/2011 JAN Low
HIROSHIMA/45/2011-OR FEB @ KUMAMOTO-C/7/2011 JAN
EHIME/4/2011 JAN Korea/664/2010.CDC DEC
GIFU-C/31/2011 FEB Low FUKUOKA-C/37/2010 NOV HIROSHIMA/55/2011 FEB Low @ IWATE/1008/2011-OR JAN Low @ SAGAMIHARA/5/2011 JAN Low KAGAWA/1/2011 JAN Low @
SHIZUOKA/37/2011 FEB Low @ Gyeongnam/3110/2010 DEC G155G/E
SHIMANE/140/2011 FEB Low NewHampshire/03/2011.CDC FEB SHIGA/43/2011 JAN Low
FUKUOKA-C/39/2010 DEC California/23/2010.CDC OCT
Connecticut/04/2011.CDC FEB Incheon/2434/2010 NOV
WAKAYAMA-C/6/2011 JAN K153Q @ CHIBA/1027/2011 JAN Low @
TOTTORI/8/2011 JAN # K153E HIROSHIMA/50/2010 NOV
ISHIKAWA/22183/2011 JAN Low SHIMANE/24/2011-OR JAN
HIROSHIMA/49/2011 FEB Low @ AKITA/1/2011-OR JAN Low
KITAKYUSYU/1/2011 JAN Low @ SHIZUOKA-C/8/2011 JAN Low
KOBE/463/2011-OR JAN HIROSHIMA/22/2011 JAN Low KUMAMOTO/7/2011 JAN G155G/E
KAGAWA/2/2011 FEB @ FUKUSHIMA/138/2010 DEC G155G/E
AKITA/5/2011 FEB Low @ SHIGA/45/2011 JAN Low
YOKOHAMA/29/2011-OR JAN @ NewYork/11/2010.CDC DEC
YAMAGATA/752/09 DEC G155E YAMAGATA/752/09 DEC G155E Laos/O066/2010 NOV
Washington/08/2011.CDC FEB Montana/06/2011.CDC MAR
Nebraska/10/2011.CDC MAR Bangladesh/5513/2011.CDC FEB
OKINAWA/40/2011 JAN @ Arkansas/01/2011.CDC JAN
Georgia/3/2011.NIMR DEC HIROSHIMA/1/2011 JAN
Florida/12/2011.CDC MAR Maryland/07/2011.CDC FEB @
Indiana/05/2011.CDC FEB Colorado/04/2011.CDC MAR
HongKong/6931/2010.CDC DEC Wisconsin/11/2011.CDC FEB
Michigan/02/2011.CDC FEB Georgia/51/2011.NIMR JAN
England/404/2010.NIMR DEC Kentucky/09/2010.CDC NOV # G155E D222G
Montana/03/2011.CDC FEB England/151/2010.NIMR NOV DARWIN/178/2010.Aus DEC
DARWIN/2/2011.Aus JAN HIROSHIMA/66/2011 FEB @
Kansas/06/2011.CDC FEB Alaska/09/2011.CDC FEB
Gyeonggi/2623/2010 NOV G155G/E SHIZUOKA/20/2011-OR JAN Low @
NIIGATA/1563/2010 DEC Texas/08/2011.CDC MAR Maryland/04/2011.CDC FEB @
Maine/03/2011.CDC MAR Georgia/25/2010.CDC DEC
NARA/54/2011 FEB @ WAKAYAMA/49/2010 DEC WAKAYAMA-C/53/2010 DEC
Christchurch/16/10E.Aus JUL D222N Soria/16/2011.NIMR JAN
OSAKA-C/25/2010 DEC SAKAI/47/2010 DEC
Taiwan/151/2010 AUG YAMAGATA/203/2011 FEB HIROSHIMA-C/28/2011 JAN
YAMAGATA/54/2011 JAN Low Washington/09/2011.CDC MAR
Pennsylvania/01/2011.CDC JAN VICTORIA/1204/2010.Aus OCT
Mississippi/07/2011.CDC FEB Laos/I969/2010 OCT
Shanghai-Zhangning/SWL1700/2010.CNIC DEC Myanmar/JP-S-026/10 JUL
OSAKA/60/10 JUL England/195/09.CDC APR
Utah/20/09.CDC JUL Utah/20/09.CDC JUL NARITA/1/09E MAY NARITA/1/09E MAY