Inexpensive and Accessible Thermal Imaging for the Detection of Cancer INFRANOSTICS Angela Fan Ben Wang Mark Bucklin Nancy Diao Olufunke Laseinde
Dec 24, 2015
Inexpensive and Accessible Thermal
Imaging for the Detection of Cancer
INFRANOSTICS
Angela FanBen WangMark BucklinNancy DiaoOlufunke Laseinde
A Device That Will:
Measure Skin-Surface Temperature
Report Topographic Location
Be Inexpensive
Software That Will:
Map and Record Spatial Temperature Fluctuations
Recognize Patterns of Carcinoma Development
A Problem and a SolutionMethods Used to
Screen and Monitor for Cancer
Current Methods
Expensive
Uncomfortable
Inconvenient
Rely on Presence of Tumor not Growth of Tumor
Detecting Cancer: Current MethodsCommon
Mammography
Self Exam
Ultrasound
Less Common
MRI
PET/CT
Thermography
From top left, clockwise: Mammogram (Harvey), Breast Self Exam, Ultrasound of the breast (Tiefenbacher), MRI of the breast with T1 contrast and fat reduction (Harvery), Combined PET and CT (Lavayssiere), Breast Thermogram (http://www.aathermography.com)
Thermography “Breast thermography has an average sensitivity and specificity of 90%”
“Breast thermography has the ability to detect the first signs that a cancer may be forming up to 10 years before any other procedure can detect it.”
“When used as part of a multimodal approach (clinical examination + mammography + thermography) 95% of early stage cancers will be detected.”
Bronzino, Joseph. The Biomedical Engineering Handbook. 3rd ed. ©2006. CRC Press. Ch.25
CMOS Focal Plane Array Cameras
~10 μm IR radiation at 36º C
FDA Approved for Screening Alongside
Mammograms
Particularly good at screening for•Breast Cancer•Pain•Neurological Disorders
Top to Bottom: Angiogenesis (http://www.gene.com/gene/research/focusareas/oncology/angiogenesis.html), Breast Thermogram (http://www.thermogramcenter.com/Images.htm)
Similar DevicesThermal Imaging CameraHandheld Optical Scanner
• Near Infrared Absorbance
• Drexel/Upenn• In Clinical Trials
Single-Sensor Thermography System
Left: Material from Drexel/Upenn device by Chance, B (http://www.biomed.drexel.edu/new04/Content/ProgressReport/fnir_breastcancer.pdf) , Center: Nec TS9100 Thermal Imaging Camera (www.metrum.co.uk) , Thermal Body Scan (http://thermalbodyscan.com/DITI.aspx). Right: Se Jin Yoon, et. Al. A Study of Thermographic Diagnosis System and Imaging Algorithmby Distributed Thermal Data using Single Infrared Sensor. Conf Proc IEEE Eng Med Biol Soc. 2007;2007:3319-22.
Design Specifications/Constraints
DesignSpecifications/
Constraints
Power-Enough power to run a complete body scan
Accessible/Inexpensive-Lightweight & Handheld-Home-Family Physician,-Humanitarian
Software-User Friendly GUI-Pattern Recognition
Versatile-Comfortable and Adaptable
Reliable-At least 95% accuracy-Detect temperature changes of ~0.1˚F
Spatially Accurate-Develop Anatomically Relevant Temperature Map
Thermopile
Components and Related Products
Gyro
Accelerometer
Optical Sensor
Optical Sensor Thermistor
Position Tracking Temperature Measurement
Design Concept #1
CPU•Process position•Display Coverage•Store Temperature•Give Directions•Diagnose via Pattern Recognition
Handheld Device•Thermopiles•Optoelectronic Sensors•Gyro/Accelerometer•IR Tracker
User
Designed with help from: http://gfx-3d-model.blogspot.com/2008/06/laptop-01.html http://www.linkwitzlab.com/Pluto/w-asp-pcb.jpg
Design Concept #2
Advantages• Form-fitting, stationary
devices allows the surveyed area to be easily mapped
• User will be familiar with and the device form
• Material will be comfortable.
Disadvantages• Needs to be made for a
variety of breast sizes.
Designed with help from: http://gfx-3d-model.blogspot.com/2008/06/laptop-01.html http://www.linkwitzlab.com/Pluto/w-asp-pcb.jpg
Design Concept #3
Advantages• No complex tracking
needed since device would be stationary
• Flexible material is suitable for a range of breast sizes
Disadvantages• May be large, and
unwieldy• May be uncomfortable
Questions?