INEB - Instituto de Engenharia Biomédica Nanostructured surfaces for blood proteins selective adsorption Inês C Gonçalves 1,2 , Mª Cristina L Martins 1 , Mário A Barbosa 1,2 1 INEB - Instituto de Engenharia Biomédica, Lab. Biomateriais, Porto, INEB - Instituto de Engenharia Biomédica, Lab. Biomateriais, Porto, Portugal Portugal 2 Univ. Porto, Univ. Porto, Fac. Engenharia, Fac. Engenharia, Dep. Eng. Metalúrgica & Materiais, Univ. Dep. Eng. Metalúrgica & Materiais, Univ. Porto, Porto, Portugal Porto, Porto, Portugal [email protected][email protected]1º Encontro Ciência em Portugal – Ciência 2007 1º Encontro Ciência em Portugal – Ciência 2007 Lisboa, 12 Abril 2007 Lisboa, 12 Abril 2007
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INEB - Instituto de Engenharia Biomédica Nanostructured surfaces for blood proteins selective adsorption Inês C Gonçalves 1,2, Mª Cristina L Martins 1,
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aNanostructured surfaces for blood
proteins selective adsorption
Inês C Gonçalves1,2, Mª Cristina L Martins1, Mário A Barbosa1,2
11 INEB - Instituto de Engenharia Biomédica, Lab. Biomateriais, Porto, PortugalINEB - Instituto de Engenharia Biomédica, Lab. Biomateriais, Porto, Portugal22 Univ. Porto,Univ. Porto, Fac. Engenharia,Fac. Engenharia, Dep. Eng. Metalúrgica & Materiais, Univ. Porto, Porto, PortugalDep. Eng. Metalúrgica & Materiais, Univ. Porto, Porto, Portugal
1º Encontro Ciência em Portugal – Ciência 20071º Encontro Ciência em Portugal – Ciência 2007
Lisboa, 12 Abril 2007Lisboa, 12 Abril 2007
Blood-material interactions
Biomaterial
Protein Adsorption
Inflammation
Complement System
Activation
Leukocyte Adhesion and
Activation
Bacterial Adhesion
Infection
Thrombosis
Platelet Adhesion and
ActivationCoagulation
System Activation
Heart valves Catheters Stents
Model surfaces - SAMs
Self-assembled monolayers (SAMs) are well-organized organic surfaces, very useful to study the properties of the interface between a material and biological media, at the molecular scale.
Form highly ordered systems
Easy to prepare
Wide range of functional groups to be explored
XX XXXX XX XX
S S S S S
XX- (CH2)n- SH
(X = OH; COOH; CH3; NH2; SO3H; etc...)gold
Research purpose
O=C=N-(CH2)17CH3
• selective for albumin
C18 ligand
C18 SAMs (0-10%)
• inhibit non-specific protein adsorption
EG4 SAMsgold
HS-(CH2)11-(O-CH2CH2)4-OH
Develop a model surface that binds albumin in a selective and reversible way in order to decrease the adhesion and activation of platelets.